The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain in...The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain incompletely understood.Polysaccharides,as a major constituent of water decoctions—the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development.The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules.This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research,focusing on methods of acquisition,structure elucidation,and quality control.展开更多
Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries ...Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries and defenses.However,challenges in both macroscale and microscale defects still limit printed component widespread applications.Recent advances in automatic and intelligent technologies have brought a range of quality controllable strategies to the forefront.This review covers these new strategies for the printing component,including path planning,process monitoring,auxiliary processes,and post processing,while discussing the expectation for structure and quality improvement.In addition,the work brings new areas of intelligent wire-arc DED development,including advances in digital twin,visualization,and human-processing interaction to promote its performance.It is anticipated that a focus on intelligent system will be key to smart and high-quality manufacturing for future wire-arc DED.展开更多
Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture....Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.展开更多
Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medi...Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).展开更多
OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently n...OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently no literature evaluating the quality of published reports,which is not conducive to the promotion of clinical use of these therapies.Therefore,this article assessed the reporting quality of randomized controlled trials on acupuncture and manipulation for greater occipital neuralgia.METHODS:Cochrane Library,PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,and Chinese BioMedical Literature Database(CBM)from inception to May 20,2024 were searched.The reporting quality of included randomized controlled trials was independently evaluated by two investigators using the CONSORT statement,STRICTA checklist,and Cochrane bias of risk assessment tool.A third investigator resolved any disagreement.RESULTS:A total of 62 articles were included.Based on the CONSORT statement,59.46%(22/37)of all entries had a reporting rate of less than 50%,mainly including“Identification as a randomized trial in the title(1/62,1.61%),”“How sample size was determined(7/62,11.29%),”“Implementation(1/62,1.61%),”“Blinding(1/62,1.61%),”and“Reports of Funding(4/62,6.45%).”According to the STRICTA checklist,29.41%(5/17)of all entries had a reporting rate of less than 50%,mainly including“Details of other interventions(7/58,12.07%),”“Setting and context of treatment(0/58,0%),”and“Description of participating acupuncturists(0/58,0%).”CONCLUSION:The reporting quality of randomized controlled trials on acupuncture and manipulation therapy for greater occipital neuralgia remains low.Future researchers need to make greater efforts to strictly adhere to the CONSORT statement and STRICTA checklist during trial design,implementation,and reporting.This will facilitate the standardization of research in this field and enhance the reliability and reproducibility of the research results.展开更多
Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed To...Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed Tomography (CT) system of LightSpeed RT16 Xtra CT scanner. Quality control was done using a vendor-provided QA Phantom, and the six aspects of image quality were measured. For CT dosimetry, Computed Tomography Dose index volume (CTDIvol) was performed using Computed Tomography Dose Index (CTDI) Phantom. CTDI Phantom consists of three parts: Pediatric Head, Adult Head, and Adult Body Phantom. A 10 cm long pencil ion chamber DCT-10 was used to measure the dose at different positions inside the CTDI Phantom. Data were collected using MagicMax Universal software. For dose estimation of the CTDIvol Report of AAPM Task Group, 96 and 111 formalisms were used. For Pediatric Head, Adult Head, and Adult Body Phantom the measured CIDIvol was 61.04 mGy, 48.11 mGy, and 18.08 mGy respectively. The study has shown deviations of 7%, 15%, and 19% between estimated and console-displayed doses for Pediatric Head, Adult Head, and Adult Body scan techniques respectively. The six aspects of image quality measured by QA Phantom were found to be compatible with the specifications of the machine and CTDIvol measured by CTDI Phantom were found within a tolerance limit of ±20%. Hence, the QC and dosimetry of the mentioned machine are within the limit.展开更多
Electric tractors(ETs)with mounted implements form operating units.There are significant differences in parameters such as shape,firmness,and moisture content of the soil in contact with the tractor and implements whe...Electric tractors(ETs)with mounted implements form operating units.There are significant differences in parameters such as shape,firmness,and moisture content of the soil in contact with the tractor and implements when working in complex terrains such as field stubble,waterlogged silt,and loose/firm terrain.These differentiated dynamics prevent cooperation between ETs and operating implements under independent control,resulting in poor quality operations and low energy efficiency.We propose a control mechanism for ETs and implements to achieve full life cycle management of collaborative control tasks,instantaneous intertask interaction,and a multitask synchronization mechanism.To address the internal redundant communication problems caused by traditional distributed microcontrol units,we break through the underlying technology of unit data processing and interaction and develop an integrated high-performance controller structure with high processing capacity and high-and low-speed communication interfaces.On the basis of hierarchical stepwise control theory,a hierarchical real-time operating system is designed.This system realizes a preemptive kernel response of computational tasks and competitive-collaborative synchronization among tasks;overcomes the low-latency response of collaborative control tasks,instantaneous information interaction,and multitask synchronization problems;and provides system-level support for deep collaborative operation control of units.To demonstrate and validate the proposed collaborative control mechanism,a plowing collaborative operation management strategy is designed and deployed.The experimental results show that the communication delay of collaborative tasks is as low as 83μs,the solution time of complex collaborative equations is as low as 46 ms,the mechanical efficiency of the ET is increased by 9.07%,the efficiency of the drive motor is increased by 9.72%,the stability of the operation speed is increased by 106.25%,and the stability of the plowing depth reaches 94.98%.Our work meets the hardware and software requirements for realizing complex collaborative control of ET units and improves the operational quality and operational energy efficiency in real vehicle demonstrations.展开更多
Laser directed energy deposition(LDED)is an emerging branch of metal-based additive manufacturing(AM)processes,offering unprecedented capabilities for high-performance fabrication with complex geometries and near-net ...Laser directed energy deposition(LDED)is an emerging branch of metal-based additive manufacturing(AM)processes,offering unprecedented capabilities for high-performance fabrication with complex geometries and near-net shapes.This technology is gathering increasing attention from industries such as biomedical,automotive,and aerospace.However,achieving consistent part quality and desired material properties is challenging due to intricate processing parameters and potential process defects such as dynamic melt-pool behavior and localized heat accumulation.This paper reviews recent advances in on-line quality control,focusing on in-situ measurement and closed-loop control for efficient assurance of LDED-fabricated parts.The quality principles,encompassing accuracy and material performance,are summarized to lay a foundation for understanding the mechanisms of quality defects and influencing factors.This review explores and thoroughly compares advancements in indirect process measurements,such as optical,thermal,and acoustic monitoring with direct quality measurements,including laser-line scanning and operando synchrotron X-ray imaging.Depending on the sensing techniques,this paper highlights a hierarchical control strategy for adaptive parameter regulation on intra-layer and inter-layer scales.The requirements and performance of various state-of-the-art controllers are critically compared to indicate their suitable applications.The importance of machine learning in detecting process anomalies and predicting build quality based on sensory signals is also outlined.Future directions are proposed towards adaptive,automated,and intelligent quality control,with a focus on multi-modal monitoring,physics-informed neural networks for interpretable analysis,and multi-objective control applications.展开更多
To investigate the efficacy of a structured continuous nursing intervention program on clinical outcomes,self-efficacy,and sleep quality in patients diagnosed with aplastic anemia(AA).Methods:This study was a single-c...To investigate the efficacy of a structured continuous nursing intervention program on clinical outcomes,self-efficacy,and sleep quality in patients diagnosed with aplastic anemia(AA).Methods:This study was a single-center,parallel-group,randomized controlled trial.A total of 64 patients with AA,treated at our hospital’s hematology department from May 2022 to May 2025,were enrolled.Participants were randomly allocated in a 1:1 ratio to either the control group(n=32),receiving routine nursing care,or the intervention group(n=32),receiving a six-month continuous nursing intervention program in addition to routine care.The intervention program consisted of structured health education,individualized psychological support,regular telephone follow-ups,and a 24/7 online communication platform.The primary outcome was the change in the Pittsburgh Sleep Quality Index(PSQI)score from baseline to six months.Secondary outcomes included hematological parameters(hemoglobin[Hb],absolute neutrophil count[ANC],platelet count[PLT]),incidence of adverse events(infections,bleeding episodes),quality of life(assessed by the Functional Assessment of Cancer Therapy–Anemia[FACT-An]),and self-efficacy(assessed by the General Self-Efficacy Scale[GSE]).Statistical analyses were performed using independent t-tests,and chi-square tests or Fisher’s exact tests as appropriate.Results:A total of 55 patients(28 in the intervention group and 27 in the control group)completed the study.At baseline,there were no statistically significant differences in demographic data,clinical characteristics,or outcome measures between the two groups(p>0.05).After six months,the mean PSQI score in the intervention group was significantly lower than that in the control group(7.12±2.05 vs.13.49±2.88;t=−13.450;p<0.001).The intervention group also demonstrated a significantly lower incidence of infections(4/28,14.29%vs.10/27,37.04%;p=0.048)and bleeding episodes requiring intervention(3/28,10.71%vs.9/27,33.33%;p=0.042).Furthermore,patients in the intervention group reported significantly higher scores on the FACT-An(125.70±10.31 vs.109.44±12.10;t=7.934;p<0.001)and the GSE scale(29.82±4.11 vs.23.51±4.80;t=7.311;p<0.001).While hematological parameters showed a trend toward improvement in the intervention group,the differences were not statistically significant compared to the control group(p>0.05).Conclusion:The implementation of a structured continuous nursing intervention program can significantly improve sleep quality,reduce the incidence of complications,and enhance quality of life and self-efficacy in patients with aplastic anemia.This evidence-based model of care should be considered for integration into standard clinical practice for the long-term management of this patient population.展开更多
Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of...Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of artificial intelligence(AI)technology has provided new approaches for the early diagnosis and management of glaucoma.By classifying and annotating glaucoma-related images,AI models can learn and recognize the specific pathological features of glaucoma,thereby achieving automated imaging analysis and classification.Research on glaucoma imaging classification and annotation mainly involves color fundus photography(CFP),optical coherence tomography(OCT),anterior segment optical coherence tomography(AS-OCT),and ultrasound biomicroscopy(UBM)images.CFP is primarily used for the annotation of the optic cup and disc,while OCT is used for measuring and annotating the thickness of the retinal nerve fiber layer,and AS-OCT and UBM focus on the annotation of the anterior chamber angle structure and the measurement of anterior segment structural parameters.To standardize the classification and annotation of glaucoma images,enhance the quality and consistency of annotated data,and promote the clinical application of intelligent ophthalmology,this guideline has been developed.This guideline systematically elaborates on the principles,methods,processes,and quality control requirements for the classification and annotation of glaucoma images,providing standardized guidance for the classification and annotation of glaucoma images.展开更多
The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder con...The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder control samples was determined by ion chromatography,and the quality control chart of fructo-oligosaccharides was established to analyze the controlled state.The results indicate that the median of the quality control chart is 1613.14 mg/100 g,and the standard deviation is 85.57 mg/100 g.The new quality control points were evaluated and analyzed,and the precision changed,but the mean value did not change.Further F test was conducted to determine that the precision did not change significantly,indicating that the test was in a statistical control state,and the detection process,method and results were controlled.展开更多
[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data...[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data file support for meteorological forecasting and services.[Method]In this paper,an efficient and accurate method for data file quality control and fusion processing is developed.By locating the missing measurement time,data are extracted from the"AWZ.db"database and the minute routine meteorological element data file,and merged into the hourly routine meteorological element data file.[Result]Data processing efficiency and accuracy are significantly improved,and the problem of incomplete hourly routine meteorological element data files is solved.At the same time,it emphasizes the importance of ensuring the accuracy of the files used and carefully checking and verifying the fusion results,and proposes strategies to improve data quality.[Conclusion]This method provides convenience for observation personnel and effectively improves the integrity and accuracy of data files.In the future,it is expected to provide more reliable data support for meteorological forecasting and services.展开更多
Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical e...Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical equipment management.However,the current process of medical equipment quality control in hospitals faces issues such as weak control awareness,untimely maintenance of faulty equipment,and a lack of informatization management tools.These problems severely restrict the development of medical equipment quality management.To address these issues,this article uses a tertiary hospital in Urumqi as an experimental platform to analyze the deficiencies in the current medical equipment quality control management system of public hospitals.Based on practical needs such as equipment procurement,contract management,and equipment management,the research is conducted from three aspects:system architecture,functional design,and talent training,utilizing an information management system.Suggestions are provided,aiming to make a modest contribution to promoting medical equipment quality control management in China.展开更多
As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utili...As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.展开更多
Additive manufacturing(AM)promotes the production of metallic parts with significant design flexibility,yet its use in critical applications is hindered by challenges in ensuring consistent quality and performance.Pro...Additive manufacturing(AM)promotes the production of metallic parts with significant design flexibility,yet its use in critical applications is hindered by challenges in ensuring consistent quality and performance.Process variability often leads to defects,insufficient geometric accuracy and inadequate material properties,which are difficult to effectively manage due to limitations of traditional quality control methods in modeling highdimensional nonlinear relationships and enabling adaptive control.Machine learning(ML)offers a transformative approach to model intricate process-structure-property relationships by leveraging the rich data environment of AM.The study presents a comprehensive examination of ML-driven quality assurance implementations in metallic AM.First,it uniquely examines the innovative exploration of ML in predicting and understanding the fundamental multi-physics fields that influence the quality of a fabricated component,including temperature fields,fluid dynamics and stress/strain evolution.Subsequently,the application of ML in optimizing key quality attributes,including defect detection and mitigation(porosity,cracks,etc.),geometric fidelity enhancement(dimensional accuracy,surface roughness,etc.)and material property tailoring(mechanical strength,fatigue life,corrosion resistance,etc.),are discussed in detail.Finally,the development of ML-driven real-time closed-loop control systems for intelligent quality assurance,the strategies for addressing the data scarcity and cross-scenario transferability in metal AM are discussed.This article provides a novel perspective on the profound potential of ML technology for metal AM quality control applications,highlights the challenges faced during research,and outlines future development directions.展开更多
Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma...Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma,PR)and yellow wine.It is a classical therapy for chest stuffiness and pain syndrome and is widely used in the clinical treatment of coronary heart disease.It also shows significant therapeutic effects on pulmonary heart disease,hyperlipidemia,and arrhythmia.This study conducted a literature review and collected information on GXBD from databases such as PubMed,Web of Science,China National Knowledge Infrastructure,and ScienceDirect.The result indicated that the main active ingredients of GXBD are steroids,flavonoids,terpenoids,alkaloids,amino acids,and organic acids.Trigonelline,macrostemonoside and cucurbitacin B can provide reference for its quality control.GXBD may exert therapeutic effects on coronary heart disease through AMPK,PI3K-AKT,oxLDL,VEGF,and NF-κB signal pathways.This review provides a comprehensive analysis and summary of the chemical composition and in vivo metabolism of three traditional Chinese medicines(TF,AMB,and PR),along with an evaluation of the chemical composition,quality control,pharmacological effects,and clinical application of GXBD.Based on these,areas requiring further research on GXBD have been proposed to provide a reference for its further development and new drug research.展开更多
Radionuclide imaging is divided into positron emission tomography and single photon emission tomography and is widely used in clinical practice for diagnosis and treatment,as well as in clinical research for the devel...Radionuclide imaging is divided into positron emission tomography and single photon emission tomography and is widely used in clinical practice for diagnosis and treatment,as well as in clinical research for the development and evaluation of new therapies.Although it is a visually intuitive form of three-dimensional functional imaging,this modality requires the injection of radiopharmaceuticals labeled with positron-or gamma-emitting isotopes into patients to assess and quantify anabolism,gene expression,and other processes.For this reason,radiopharmaceuticals must undergo rigorous quality control(QC)to ensure product purity,efficacy,and safety.Traditional QC of pharmaceuticals is manual,requiring specially trained personnel,a range of expensive analytical and chemical equipment and laboratory space,the consumption of many samples,and usually a long time.Compared with ordinary pharmaceuticals,radiopharmaceuticals have the following unique characteristics:radioactivity,short lifetime,low synthesis yield,and high cost.Therefore,analytical methods and instrumentation must be exclusively developed for the QC of radiopharmaceuticals to avoid large losses owing to radioactive decay or handling.Microfluidics integrates microchannels or microchambers into several square centimeters of a microscale chip through micro-nanofabrication,allowing a precise manipulation of the fluid in microtubules,where various traditional physical,chemical,or biological experiments occur.Microfluidics is gaining attention in the field of analytical testing owing to significantly reduced consumption of samples and reagents,reduced analysis time,increased detection sensitivity,increased multiplexing,and reduced instrument size.Features such as micro size,micro volume,high sensitivity,and on-line testing have led to increasing interest in microfluidics.This review covers the development of integrated microfluidic QC devices that can automatically process,test,analyze,and calculate completed test metrics online.展开更多
Building HVAC equipment installation is vital for indoor comfort,energy efficiency,and environmental quality.Key technologies like vibration control,pipe network alignment,and thermal stress compensation,along with a ...Building HVAC equipment installation is vital for indoor comfort,energy efficiency,and environmental quality.Key technologies like vibration control,pipe network alignment,and thermal stress compensation,along with a multi-faceted quality standards framework,are crucial.Effective process management,practical application analysis,and the integration of robotics,IoT,and AI enhance quality and efficiency.Sustainable development strategies and lifecycle-oriented quality management are also essential for future progress.展开更多
This research focuses on quality control strategies in real estate HVAC engineering construction management.It first elaborates on the role of HVAC systems and challenges like material compliance risks and installatio...This research focuses on quality control strategies in real estate HVAC engineering construction management.It first elaborates on the role of HVAC systems and challenges like material compliance risks and installation deficiencies.Then it details design validation,vendor qualification,and construction-phase monitoring methods.Case studies in various real estate projects illustrate these strategies,and a 5-phase quality maturity model was proposed for quality improvement.展开更多
This paper expounds the characteristics of BIM technology,including visualization,parameterization,and collaboration.It analyzes the quality control requirements of real estate projects and the problems of the traditi...This paper expounds the characteristics of BIM technology,including visualization,parameterization,and collaboration.It analyzes the quality control requirements of real estate projects and the problems of the traditional control system.It introduces the quality control strategies based on BIM,such as constructing the framework,combining with technologies to control deviations,etc.It also mentions the PDCA mechanism,application terminals,etc.,and points out the application obstacles and future development directions.展开更多
基金supported by the Science and Technology Development Fund,Macao SAR (Nos.0075/2022/A and028/2022/ITP)the Zhuhai Science and Technology Plan Project in the Social Development Field (No.2220004000117)the University of Macao (Nos.MYRG-GRG2023-00082-ICMS-UMDF/CPG2024-00011-ICMS)。
文摘The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain incompletely understood.Polysaccharides,as a major constituent of water decoctions—the most common preparation method for Chinese medicinals—may provide a crucial avenue for deepening our understanding of the efficacy principles of Chinese medicine and establishing a framework for its modern development.The structural complexity and diversity of Chinese herbal polysaccharides present significant challenges in their separation and analysis compared to small molecules.This paper aims to explore the potential of Chinese herbal polysaccharides efficiently by briefly summarizing recent advancements in polysaccharide chemical research,focusing on methods of acquisition,structure elucidation,and quality control.
基金fully appreciate financial support from NingXia Natural Science Foundation for Outstanding Young Scholar(No.2024AAC04002)CAS“Light of West China”Program,National Natural Science Foundation of China(Key Program,No.12232013)Natural Science Foundation of Ningxia(Key Program,No.2022AAC2003)。
文摘Wire-arc directed energy deposition(wire-arc DED)enables the fabrication of large-scale metal components with rapid manufacturing ability and diverse material selection,making it a compelling technology in industries and defenses.However,challenges in both macroscale and microscale defects still limit printed component widespread applications.Recent advances in automatic and intelligent technologies have brought a range of quality controllable strategies to the forefront.This review covers these new strategies for the printing component,including path planning,process monitoring,auxiliary processes,and post processing,while discussing the expectation for structure and quality improvement.In addition,the work brings new areas of intelligent wire-arc DED development,including advances in digital twin,visualization,and human-processing interaction to promote its performance.It is anticipated that a focus on intelligent system will be key to smart and high-quality manufacturing for future wire-arc DED.
基金supported by the National Key Research and Development Project (2021YFA1201404)National Natural Science Foundation of China Major Project (81991514)+6 种基金General Project (82272530, 82372459)Jiangsu Province Medical Innovation Center of Orthopedic Surgery (CXZX202214)Jiangsu Provincial Key Medical Center FoundationJiangsu Provincial Medical Outstanding Talent FoundationJiangsu Provincial Medical Youth Talent FoundationJiangsu Provincial Key Medical Talent Foundationthe Fundamental Research Funds for the Central Universities (14380493, 14380494)
文摘Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus(T2DM),which is characterized by suppressed osteoblast function and disrupted bone microarchitecture.In this study,we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM.Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.Mechanistically,SIRT3 suppression results in hyperacetylation of FOXO3,hindering the activation of the PINK1/PRKN mediated mitophagy pathway and resulting in accumulation of dysfunctional mitochondria.Genetical overexpression or pharmacological activation of SIRT3 restores deacetylation status of FOXO3,thus facilitating mitophagy and ameliorating osteogenic impairment in T2DM.Collectively,our findings highlight the fundamental regulatory function of SIRT3 in mitochondrial quality control,crucial for maintaining bone homeostasis in T2DM.These insights not only enhance our understanding of the molecular mechanisms underlying diabetic osteoporosis but also identify SIRT3 as a promising therapeutic target for diabetic osteoporosis.
基金funded by the National Natural Science Foundation of China(Grant Nos.:82222068,82070423,82270348,and 82173779)the Innovation Team and Talents Cultivation Pro-gram of National Administration of Traditional Chinese Medicine,China(Grant No:ZYYCXTD-D-202206)+1 种基金Fujian Province Science and Technology Project,China(Grant Nos.:2021J01420479,2021J02058,2022J011374,and 2022J02057)Fundamental Research Funds for the Chinese Central Universities,China(Grant No.:20720230070).
文摘Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).
文摘OBJECTIVE:In recent years,the number of clinical research reports on acupuncture and manipulation for the treatment of greater occipital neuralgia has gradually increased,but the quality is uneven.There is currently no literature evaluating the quality of published reports,which is not conducive to the promotion of clinical use of these therapies.Therefore,this article assessed the reporting quality of randomized controlled trials on acupuncture and manipulation for greater occipital neuralgia.METHODS:Cochrane Library,PubMed,Web of Science,Embase,China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,and Chinese BioMedical Literature Database(CBM)from inception to May 20,2024 were searched.The reporting quality of included randomized controlled trials was independently evaluated by two investigators using the CONSORT statement,STRICTA checklist,and Cochrane bias of risk assessment tool.A third investigator resolved any disagreement.RESULTS:A total of 62 articles were included.Based on the CONSORT statement,59.46%(22/37)of all entries had a reporting rate of less than 50%,mainly including“Identification as a randomized trial in the title(1/62,1.61%),”“How sample size was determined(7/62,11.29%),”“Implementation(1/62,1.61%),”“Blinding(1/62,1.61%),”and“Reports of Funding(4/62,6.45%).”According to the STRICTA checklist,29.41%(5/17)of all entries had a reporting rate of less than 50%,mainly including“Details of other interventions(7/58,12.07%),”“Setting and context of treatment(0/58,0%),”and“Description of participating acupuncturists(0/58,0%).”CONCLUSION:The reporting quality of randomized controlled trials on acupuncture and manipulation therapy for greater occipital neuralgia remains low.Future researchers need to make greater efforts to strictly adhere to the CONSORT statement and STRICTA checklist during trial design,implementation,and reporting.This will facilitate the standardization of research in this field and enhance the reliability and reproducibility of the research results.
文摘Dose estimation and quality control in computed tomography (CT) scanners are useful in controlling the dose of radiation given to patients while tests are carried out. The study was performed in a 16-slice Computed Tomography (CT) system of LightSpeed RT16 Xtra CT scanner. Quality control was done using a vendor-provided QA Phantom, and the six aspects of image quality were measured. For CT dosimetry, Computed Tomography Dose index volume (CTDIvol) was performed using Computed Tomography Dose Index (CTDI) Phantom. CTDI Phantom consists of three parts: Pediatric Head, Adult Head, and Adult Body Phantom. A 10 cm long pencil ion chamber DCT-10 was used to measure the dose at different positions inside the CTDI Phantom. Data were collected using MagicMax Universal software. For dose estimation of the CTDIvol Report of AAPM Task Group, 96 and 111 formalisms were used. For Pediatric Head, Adult Head, and Adult Body Phantom the measured CIDIvol was 61.04 mGy, 48.11 mGy, and 18.08 mGy respectively. The study has shown deviations of 7%, 15%, and 19% between estimated and console-displayed doses for Pediatric Head, Adult Head, and Adult Body scan techniques respectively. The six aspects of image quality measured by QA Phantom were found to be compatible with the specifications of the machine and CTDIvol measured by CTDI Phantom were found within a tolerance limit of ±20%. Hence, the QC and dosimetry of the mentioned machine are within the limit.
基金supported by the National Key Research and Development Plan of China(2022YFD2001202)the National Natural Science Foundation of China(32301719 and 52272444)the 2115 Talent Development Program of China Agricultural University.
文摘Electric tractors(ETs)with mounted implements form operating units.There are significant differences in parameters such as shape,firmness,and moisture content of the soil in contact with the tractor and implements when working in complex terrains such as field stubble,waterlogged silt,and loose/firm terrain.These differentiated dynamics prevent cooperation between ETs and operating implements under independent control,resulting in poor quality operations and low energy efficiency.We propose a control mechanism for ETs and implements to achieve full life cycle management of collaborative control tasks,instantaneous intertask interaction,and a multitask synchronization mechanism.To address the internal redundant communication problems caused by traditional distributed microcontrol units,we break through the underlying technology of unit data processing and interaction and develop an integrated high-performance controller structure with high processing capacity and high-and low-speed communication interfaces.On the basis of hierarchical stepwise control theory,a hierarchical real-time operating system is designed.This system realizes a preemptive kernel response of computational tasks and competitive-collaborative synchronization among tasks;overcomes the low-latency response of collaborative control tasks,instantaneous information interaction,and multitask synchronization problems;and provides system-level support for deep collaborative operation control of units.To demonstrate and validate the proposed collaborative control mechanism,a plowing collaborative operation management strategy is designed and deployed.The experimental results show that the communication delay of collaborative tasks is as low as 83μs,the solution time of complex collaborative equations is as low as 46 ms,the mechanical efficiency of the ET is increased by 9.07%,the efficiency of the drive motor is increased by 9.72%,the stability of the operation speed is increased by 106.25%,and the stability of the plowing depth reaches 94.98%.Our work meets the hardware and software requirements for realizing complex collaborative control of ET units and improves the operational quality and operational energy efficiency in real vehicle demonstrations.
基金supported by Royal Academy of Engineering(IF2223B-125)Royal Society(IECR3213107)。
文摘Laser directed energy deposition(LDED)is an emerging branch of metal-based additive manufacturing(AM)processes,offering unprecedented capabilities for high-performance fabrication with complex geometries and near-net shapes.This technology is gathering increasing attention from industries such as biomedical,automotive,and aerospace.However,achieving consistent part quality and desired material properties is challenging due to intricate processing parameters and potential process defects such as dynamic melt-pool behavior and localized heat accumulation.This paper reviews recent advances in on-line quality control,focusing on in-situ measurement and closed-loop control for efficient assurance of LDED-fabricated parts.The quality principles,encompassing accuracy and material performance,are summarized to lay a foundation for understanding the mechanisms of quality defects and influencing factors.This review explores and thoroughly compares advancements in indirect process measurements,such as optical,thermal,and acoustic monitoring with direct quality measurements,including laser-line scanning and operando synchrotron X-ray imaging.Depending on the sensing techniques,this paper highlights a hierarchical control strategy for adaptive parameter regulation on intra-layer and inter-layer scales.The requirements and performance of various state-of-the-art controllers are critically compared to indicate their suitable applications.The importance of machine learning in detecting process anomalies and predicting build quality based on sensory signals is also outlined.Future directions are proposed towards adaptive,automated,and intelligent quality control,with a focus on multi-modal monitoring,physics-informed neural networks for interpretable analysis,and multi-objective control applications.
文摘To investigate the efficacy of a structured continuous nursing intervention program on clinical outcomes,self-efficacy,and sleep quality in patients diagnosed with aplastic anemia(AA).Methods:This study was a single-center,parallel-group,randomized controlled trial.A total of 64 patients with AA,treated at our hospital’s hematology department from May 2022 to May 2025,were enrolled.Participants were randomly allocated in a 1:1 ratio to either the control group(n=32),receiving routine nursing care,or the intervention group(n=32),receiving a six-month continuous nursing intervention program in addition to routine care.The intervention program consisted of structured health education,individualized psychological support,regular telephone follow-ups,and a 24/7 online communication platform.The primary outcome was the change in the Pittsburgh Sleep Quality Index(PSQI)score from baseline to six months.Secondary outcomes included hematological parameters(hemoglobin[Hb],absolute neutrophil count[ANC],platelet count[PLT]),incidence of adverse events(infections,bleeding episodes),quality of life(assessed by the Functional Assessment of Cancer Therapy–Anemia[FACT-An]),and self-efficacy(assessed by the General Self-Efficacy Scale[GSE]).Statistical analyses were performed using independent t-tests,and chi-square tests or Fisher’s exact tests as appropriate.Results:A total of 55 patients(28 in the intervention group and 27 in the control group)completed the study.At baseline,there were no statistically significant differences in demographic data,clinical characteristics,or outcome measures between the two groups(p>0.05).After six months,the mean PSQI score in the intervention group was significantly lower than that in the control group(7.12±2.05 vs.13.49±2.88;t=−13.450;p<0.001).The intervention group also demonstrated a significantly lower incidence of infections(4/28,14.29%vs.10/27,37.04%;p=0.048)and bleeding episodes requiring intervention(3/28,10.71%vs.9/27,33.33%;p=0.042).Furthermore,patients in the intervention group reported significantly higher scores on the FACT-An(125.70±10.31 vs.109.44±12.10;t=7.934;p<0.001)and the GSE scale(29.82±4.11 vs.23.51±4.80;t=7.311;p<0.001).While hematological parameters showed a trend toward improvement in the intervention group,the differences were not statistically significant compared to the control group(p>0.05).Conclusion:The implementation of a structured continuous nursing intervention program can significantly improve sleep quality,reduce the incidence of complications,and enhance quality of life and self-efficacy in patients with aplastic anemia.This evidence-based model of care should be considered for integration into standard clinical practice for the long-term management of this patient population.
基金Supported by Guangdong Basic and Applied Basic Research Foundation(No.2025A1515011627)San Ming Project of Medicine in Shenzhen(No.SZSM202311012).
文摘Glaucoma is an eye disease characterized by pathologically elevated intraocular pressure,optic nerve atrophy,and visual field defects,which can lead to irreversible vision loss.In recent years,the rapid development of artificial intelligence(AI)technology has provided new approaches for the early diagnosis and management of glaucoma.By classifying and annotating glaucoma-related images,AI models can learn and recognize the specific pathological features of glaucoma,thereby achieving automated imaging analysis and classification.Research on glaucoma imaging classification and annotation mainly involves color fundus photography(CFP),optical coherence tomography(OCT),anterior segment optical coherence tomography(AS-OCT),and ultrasound biomicroscopy(UBM)images.CFP is primarily used for the annotation of the optic cup and disc,while OCT is used for measuring and annotating the thickness of the retinal nerve fiber layer,and AS-OCT and UBM focus on the annotation of the anterior chamber angle structure and the measurement of anterior segment structural parameters.To standardize the classification and annotation of glaucoma images,enhance the quality and consistency of annotated data,and promote the clinical application of intelligent ophthalmology,this guideline has been developed.This guideline systematically elaborates on the principles,methods,processes,and quality control requirements for the classification and annotation of glaucoma images,providing standardized guidance for the classification and annotation of glaucoma images.
基金Supported by the Inner Mongolia Autonomous Region's Key Research and Achievement Transformation plan (2023YFHH0093).
文摘The quality control chart of fructo-oligosaccharides in milk powder was established to determine whether the detection process and results are in control state.The content of fructo-oligosaccharides in milk powder control samples was determined by ion chromatography,and the quality control chart of fructo-oligosaccharides was established to analyze the controlled state.The results indicate that the median of the quality control chart is 1613.14 mg/100 g,and the standard deviation is 85.57 mg/100 g.The new quality control points were evaluated and analyzed,and the precision changed,but the mean value did not change.Further F test was conducted to determine that the precision did not change significantly,indicating that the test was in a statistical control state,and the detection process,method and results were controlled.
基金the Fifth Batch of Innovation Teams of Wuzhou Meteorological Bureau"Wuzhou Innovation Team for Enhancing the Comprehensive Meteorological Observation Ability through Digitization and Intelligence"Wuzhou Science and Technology Planning Project(202402122,202402119).
文摘[Objective]In response to the issue of insufficient integrity in hourly routine meteorological element data files,this paper aims to improve the availability and reliability of data files,and provide high-quality data file support for meteorological forecasting and services.[Method]In this paper,an efficient and accurate method for data file quality control and fusion processing is developed.By locating the missing measurement time,data are extracted from the"AWZ.db"database and the minute routine meteorological element data file,and merged into the hourly routine meteorological element data file.[Result]Data processing efficiency and accuracy are significantly improved,and the problem of incomplete hourly routine meteorological element data files is solved.At the same time,it emphasizes the importance of ensuring the accuracy of the files used and carefully checking and verifying the fusion results,and proposes strategies to improve data quality.[Conclusion]This method provides convenience for observation personnel and effectively improves the integrity and accuracy of data files.In the future,it is expected to provide more reliable data support for meteorological forecasting and services.
基金Urumqi Health Committee Science and Technology Plan Project(202343)。
文摘Relevant documents issued by the General Office of the State Council and the Ministry of Health require hospitals to reduce operating costs and improve efficiency,which will place newer and higher demands on medical equipment management.However,the current process of medical equipment quality control in hospitals faces issues such as weak control awareness,untimely maintenance of faulty equipment,and a lack of informatization management tools.These problems severely restrict the development of medical equipment quality management.To address these issues,this article uses a tertiary hospital in Urumqi as an experimental platform to analyze the deficiencies in the current medical equipment quality control management system of public hospitals.Based on practical needs such as equipment procurement,contract management,and equipment management,the research is conducted from three aspects:system architecture,functional design,and talent training,utilizing an information management system.Suggestions are provided,aiming to make a modest contribution to promoting medical equipment quality control management in China.
文摘As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.
基金supported by the National Key R&D Program of China(No.2024YFB4609700)Major Research Plan of the National Natural Science Foundation of China(No.92266102)+4 种基金National Natural Science Foundation of China(No.52271135,No.52433016)Open project of Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials,China(No.GFST2024KF05)Innovative Research Group Project of Hubei Provincial Natural Science Foundation,China(No.2025AFA014)ECU DVC Strategic Research Support Fund,Australia(No.23965)Natural Science Foundation of Hubei Province,China(No.2025AFD399).
文摘Additive manufacturing(AM)promotes the production of metallic parts with significant design flexibility,yet its use in critical applications is hindered by challenges in ensuring consistent quality and performance.Process variability often leads to defects,insufficient geometric accuracy and inadequate material properties,which are difficult to effectively manage due to limitations of traditional quality control methods in modeling highdimensional nonlinear relationships and enabling adaptive control.Machine learning(ML)offers a transformative approach to model intricate process-structure-property relationships by leveraging the rich data environment of AM.The study presents a comprehensive examination of ML-driven quality assurance implementations in metallic AM.First,it uniquely examines the innovative exploration of ML in predicting and understanding the fundamental multi-physics fields that influence the quality of a fabricated component,including temperature fields,fluid dynamics and stress/strain evolution.Subsequently,the application of ML in optimizing key quality attributes,including defect detection and mitigation(porosity,cracks,etc.),geometric fidelity enhancement(dimensional accuracy,surface roughness,etc.)and material property tailoring(mechanical strength,fatigue life,corrosion resistance,etc.),are discussed in detail.Finally,the development of ML-driven real-time closed-loop control systems for intelligent quality assurance,the strategies for addressing the data scarcity and cross-scenario transferability in metal AM are discussed.This article provides a novel perspective on the profound potential of ML technology for metal AM quality control applications,highlights the challenges faced during research,and outlines future development directions.
基金National Natural ScienceFoundation of China (grant number: 81973696).
文摘Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma,PR)and yellow wine.It is a classical therapy for chest stuffiness and pain syndrome and is widely used in the clinical treatment of coronary heart disease.It also shows significant therapeutic effects on pulmonary heart disease,hyperlipidemia,and arrhythmia.This study conducted a literature review and collected information on GXBD from databases such as PubMed,Web of Science,China National Knowledge Infrastructure,and ScienceDirect.The result indicated that the main active ingredients of GXBD are steroids,flavonoids,terpenoids,alkaloids,amino acids,and organic acids.Trigonelline,macrostemonoside and cucurbitacin B can provide reference for its quality control.GXBD may exert therapeutic effects on coronary heart disease through AMPK,PI3K-AKT,oxLDL,VEGF,and NF-κB signal pathways.This review provides a comprehensive analysis and summary of the chemical composition and in vivo metabolism of three traditional Chinese medicines(TF,AMB,and PR),along with an evaluation of the chemical composition,quality control,pharmacological effects,and clinical application of GXBD.Based on these,areas requiring further research on GXBD have been proposed to provide a reference for its further development and new drug research.
基金supported by National Natural Science Foundation of China(Grants 32027802 and 22178307)National Key Research and Development Program of China(Grant 2021YFA1101700)the Science Technology Department of Zhejiang Province(Grant 2024C03100).
文摘Radionuclide imaging is divided into positron emission tomography and single photon emission tomography and is widely used in clinical practice for diagnosis and treatment,as well as in clinical research for the development and evaluation of new therapies.Although it is a visually intuitive form of three-dimensional functional imaging,this modality requires the injection of radiopharmaceuticals labeled with positron-or gamma-emitting isotopes into patients to assess and quantify anabolism,gene expression,and other processes.For this reason,radiopharmaceuticals must undergo rigorous quality control(QC)to ensure product purity,efficacy,and safety.Traditional QC of pharmaceuticals is manual,requiring specially trained personnel,a range of expensive analytical and chemical equipment and laboratory space,the consumption of many samples,and usually a long time.Compared with ordinary pharmaceuticals,radiopharmaceuticals have the following unique characteristics:radioactivity,short lifetime,low synthesis yield,and high cost.Therefore,analytical methods and instrumentation must be exclusively developed for the QC of radiopharmaceuticals to avoid large losses owing to radioactive decay or handling.Microfluidics integrates microchannels or microchambers into several square centimeters of a microscale chip through micro-nanofabrication,allowing a precise manipulation of the fluid in microtubules,where various traditional physical,chemical,or biological experiments occur.Microfluidics is gaining attention in the field of analytical testing owing to significantly reduced consumption of samples and reagents,reduced analysis time,increased detection sensitivity,increased multiplexing,and reduced instrument size.Features such as micro size,micro volume,high sensitivity,and on-line testing have led to increasing interest in microfluidics.This review covers the development of integrated microfluidic QC devices that can automatically process,test,analyze,and calculate completed test metrics online.
文摘Building HVAC equipment installation is vital for indoor comfort,energy efficiency,and environmental quality.Key technologies like vibration control,pipe network alignment,and thermal stress compensation,along with a multi-faceted quality standards framework,are crucial.Effective process management,practical application analysis,and the integration of robotics,IoT,and AI enhance quality and efficiency.Sustainable development strategies and lifecycle-oriented quality management are also essential for future progress.
文摘This research focuses on quality control strategies in real estate HVAC engineering construction management.It first elaborates on the role of HVAC systems and challenges like material compliance risks and installation deficiencies.Then it details design validation,vendor qualification,and construction-phase monitoring methods.Case studies in various real estate projects illustrate these strategies,and a 5-phase quality maturity model was proposed for quality improvement.
文摘This paper expounds the characteristics of BIM technology,including visualization,parameterization,and collaboration.It analyzes the quality control requirements of real estate projects and the problems of the traditional control system.It introduces the quality control strategies based on BIM,such as constructing the framework,combining with technologies to control deviations,etc.It also mentions the PDCA mechanism,application terminals,etc.,and points out the application obstacles and future development directions.
