This study examined the development of technician teams on large-scale instrument platforms in universities,using the State Key Laboratory of Natural and Biomimetic Drugs in the Peking University School of Pharmaceuti...This study examined the development of technician teams on large-scale instrument platforms in universities,using the State Key Laboratory of Natural and Biomimetic Drugs in the Peking University School of Pharmaceutical Sciences as a case study.Data were collected through questionnaire surveys and interviews conducted in 2017,followed by a questionnaire survey in 2023,offering both subjective and objective insights.The evolution of the platform’s technician team over the past 5 years was analyzed,highlighting key experiences and identifying ongoing challenges.Recommendations to enhance technician team development include recruiting skilled faculty,clearly defining job responsibilities,and refining the assessment and incentive systems.展开更多
In March 2022,construction was started at Yunlong Lake Laboratory of Deep Underground Science and Engineering,China,on an underground gas storage experimental facility with the capacity to achieve composite structure ...In March 2022,construction was started at Yunlong Lake Laboratory of Deep Underground Science and Engineering,China,on an underground gas storage experimental facility with the capacity to achieve composite structure design and material development.Underground gas storage can provide a solution to address the intermittency of renewable energy supply.Currently,lined rock caverns(LRCs)are regarded as the best option for compressed air and hydrogen storage,since they have excellent sealing properties and minimum environmental impacts.However,the load transfer,damage,and failure mechanisms of LRCs are not clear.This prevents the design and selection of mechanical structures.Particularly,the gas sealing capacity in specific gas conditions(e.g.,stored hydrogen-induced chemical reaction)remains poorly understood,and advanced materials to adapt the storage conditions of different gases should be developed.This experimental facility aims at providing a solution to these technical issues.This facility has several different types of LRCs,and study of the mechanical behavior of various structures and evaluation of the gas-tight performance of the sealing material can be carried out using a distributed fiberoptic sensing approach.The focus of this study is on the challenges in sealing material development and structure design.This facility facilitates large-scale and long-term energy storage for stable and continuous energy supply,and enables repurposing of underground space and acceleration of the realization of green energy ambitions in the context of Paris Agreement and China's carbon neutralization plan.展开更多
With the rapid development of marine oil and gas exploitation,the evacuation of offshore platforms has received more attention.First,an experimental investigation of the evacuation process of 120 participants in a rea...With the rapid development of marine oil and gas exploitation,the evacuation of offshore platforms has received more attention.First,an experimental investigation of the evacuation process of 120 participants in a real offshore platform is performed,and then simulation results provided by Pathfinder are validated against the measurement results.Second,four typical evacuation scenarios on the platform referring to IMO guidelines are investigated by Pathfinder with the speed values achieved in experiments.The simulation results show that both the utilization of exits and evacuation efficiency of people on the offshore platform need to be further improved.Last,the evacuation routes of people under the four scenarios are optimized,and the improvement of the evacuation performance after the optimization is evaluated by several mathematical indicators.Final results show that the evacuation with the optimized route design prompts the use efficiency of exits and further reduces the evacuation time.The present study provides a useful advice for potentially revising the IMO guidelines in future and provides efficient evacuation strategies for planning the emergency evacuation on offshore platforms.展开更多
With the rapid development of urban rail transit,there have been an urgent problem of excessive stray current.Because the stray current distribution is random and difficult to verify in the field,we designed an improv...With the rapid development of urban rail transit,there have been an urgent problem of excessive stray current.Because the stray current distribution is random and difficult to verify in the field,we designed an improved stray current experimental platform by replacing the simulated aqueous solution with a real soil environment and by calculating the transition resistance by measuring the soil resistivity,which makes up for the defects in the previous references.Firstly,the mathematical models of rail-drainage net and rail-drainage netground were established,and the analytical expressions of current and voltage of rail,drainage net and other structures were derived.In addition,the simulation model was built,and the mathematical analysis results were compared with the simulation results.Secondly,the accuracy of the improved stray current experimental platform was verified by comparing the measured and simulation results.Finally,based on the experimental results,the influence factors of stray current were analyzed.The relevant conclusions provide experimental data and theoretical reference for the study of stray current in urban rail transit.展开更多
In view of the key role of undergraduate experimental teaching reform in cultivating high-quality talents with both innovative spirit and practical ability,this paper deeply discusses multi-dimensional reform strategi...In view of the key role of undergraduate experimental teaching reform in cultivating high-quality talents with both innovative spirit and practical ability,this paper deeply discusses multi-dimensional reform strategies.Specifically,the teaching mode of"double teachers for every student"is innovatively introduced,and scientific research projects are deeply integrated into undergraduate experimental teaching,aiming at realizing the modern development of teaching content and the diversified expansion of teaching methods.By designing and applying the undergraduate experimental teaching platform for intelligent limb rehabilitation training based on the concept of"medical-engineering interdisciplinary crossing",it not only builds a bridge for students to contact cutting-edge scientific research and strengthen practical skills,but also provides valuable ideas and practical models for the innovation of undergraduate experimental teaching.In the future,with the continuous optimization and upgrading of platform functions,it is expected to provide students with a richer and richer learning experience and comprehensively promote students'overall quality.展开更多
With the advancement of vocational education reform,education informationization,and digitalization have become the important direction of the reform of electrical and electronic teaching in high vocational colleges.I...With the advancement of vocational education reform,education informationization,and digitalization have become the important direction of the reform of electrical and electronic teaching in high vocational colleges.In this context,intelligent product development of professional electrical and electronic teaching should also do a good job in practice and innovation,especially in actively building a digital experimental teaching platform and promoting the reform of experimental teaching mode,so that students can learn more useful knowledge and skills in the new platform,and cultivate more applied and skilled talents for society.While analyzing the problems existing in the traditional electrical and electronic experimental teaching mode,this paper analyzes the significance and practical path of the construction of electrical and electronic experimental teaching platforms in higher vocational colleges which can be of reference in future research.展开更多
In recent years, attention has been focused on the spar platform for gas and oil exploitation in deep water. With the development of offshore technology, many new spar concepts have been put forward and fully studied....In recent years, attention has been focused on the spar platform for gas and oil exploitation in deep water. With the development of offshore technology, many new spar concepts have been put forward and fully studied. This paper presents the results of an experimental investigation on the hydrodynamic behavior of a new spar concept from Novellent Offshore LLC, USA, which is called Ceometrie Spar （G-spar）. A new type of buoyancy can concept from the same company, viz. Integratod Buoyancy Can （IBC）, is researched in the meantime. The G-spar and IBC models with a 1：70 scale are tested in the State Key Laboratory of Ocean Engineering at Shanghai Jiao Tong University for the global performance of the spar hull, in which the second-order wave drift force is involved, as well as the effect of heave plates on the motion characteristics and mooring force of the G-spar platform.展开更多
The combination of nucleic acid and small-molecule drugs in tumor treatment holds significant promise;however,the precise delivery and controlled release of drugs within the cytoplasm encounter substantial obstacles,i...The combination of nucleic acid and small-molecule drugs in tumor treatment holds significant promise;however,the precise delivery and controlled release of drugs within the cytoplasm encounter substantial obstacles,impeding the advancement of formulations.To surmount the challenges associated with precise drug delivery and controlled release,we have developed a multi-level p H-responsive co-loaded drug lipid nanoplatform.This platform first employs cyclic cell-penetrating peptides to exert a multi-level pH response,thereby enhancing the uptake efficiency of tumor cells and endow the nanosystem with effective endosomal/lysosomal escape.Subsequently,small interferring RNA(siRNA)complexes are formed by compacting siRNA with stearic acid octahistidine,which is capable of responding to the lysosome-tocytoplasm pH gradient and facilitate siRNA release.The siRNA complexes and docetaxel are simultaneously encapsulated into liposomes,thereby creating a lipid nanoplatform capable of co-delivering nucleic acid and small-molecule drugs.The efficacy of this platform has been validated through both in vitro and in vivo experiments,affirming its significant potential for practical applications in the co-delivery of nucleic acids and small-molecule drugs.展开更多
To take advantage of the abundance of both fishery and wave energy resources in offshore sea areas,a novel floating platform with a heaving buoy-based wave energy converter(WEC)assembled with a set of net cages is pre...To take advantage of the abundance of both fishery and wave energy resources in offshore sea areas,a novel floating platform with a heaving buoy-based wave energy converter(WEC)assembled with a set of net cages is presented in this work.The floating WEC system provides a power supply,while the net cages are used for aquaculture.It is designed to have an independent and self-operation breeding function.An experimental study is carried out to investigate the hydrodynamic performance of the device in a wave tank considering the factors of net cages,draft depth,and power take-off,and results show that these variables have significant effects on wave energy capture.Incident waves with short periods cause intense interactions that allow the device to undergo large relative motion.The draft depth could be determined according to wave period rather than wave height.This study also explores the response amplitude operator of the device and determines its resonance scope.The experimental results could provide reliable information for future studies on phase differences and the design of two-body WECs.展开更多
Magnetorheological （MR） dampers have been proposed to control the vibration of offshore platforms in this paper. The semi-active control strategy based on fuzzy control algorithm was adopted to determine the optimal...Magnetorheological （MR） dampers have been proposed to control the vibration of offshore platforms in this paper. The semi-active control strategy based on fuzzy control algorithm was adopted to determine the optimal output control force based on the responses of jacket platforms. A typical jacket platform in Mexico Gulf was selected as the numerical example to investigate the effectiveness of the proposed control method. Furthermore, a model experiment was performed to validate the results of the numerical simulation. The experimental model of the jacket platform was designed based on dynamical similarity criterion by the scale of 1：50. Both of the numerical and experimental results show that the semi-active control system with the MR damper can reduce vibrations of jacket platforms effectively and at the same time the control effect is stable.展开更多
A control model of binocular vergence eye movements is presented. The control model can reduce blind areas caused by the double cameras in motion platform. In order to validate the model performance, an experimental p...A control model of binocular vergence eye movements is presented. The control model can reduce blind areas caused by the double cameras in motion platform. In order to validate the model performance, an experimental platform and its control system based on TMS320LF2407 are designed. The control system has its compacted configuration and high reliability. The simulation and experimental results show that the control system can realize binocular vergence movements. Compared with the conventional moving double cameras system, this new system can considerably reduce blind areas.展开更多
Practice training is very important for students learning Computer networks.But building a real laboratory is constrained and expensive.In this paper,we present an online experimental platform for computer networks co...Practice training is very important for students learning Computer networks.But building a real laboratory is constrained and expensive.In this paper,we present an online experimental platform for computer networks course based on Dynamips simulator.Instructors and students can access the platform by IE Browser to manage and take router experiments.On the basis of deployment and testing,the platform is effective and flexible.展开更多
Experiments involving a sonar platform with a sound absorption wedge were carried out for the purpose of obtaining the low frequency acoustic characteristics. Acoustic characteristics of a sonar platform model with a ...Experiments involving a sonar platform with a sound absorption wedge were carried out for the purpose of obtaining the low frequency acoustic characteristics. Acoustic characteristics of a sonar platform model with a sound absorption wedge were measured, and the effects of different wedge laid areas on platform acoustic characteristic were tested. Vibration acceleration and self-noise caused by model vibration were measured in four conditions: 0%, 36%, 60%, and 100% of wedge laid area when the sonar platform was under a single frequency excitation force. An experiment was performed to validate a corresponding numerical calculation. The numerical vibration characteristics of platform area were calculated by the finite element method, and self-noise caused by the vibration in it was predicted by an experiential formula. The conclusions prove that the numerical calculation method can partially replace the experimental process for obtaining vibration and sound characteristics.展开更多
With the advancement and maturation of digital technology,immersive experiences,virtual interactive systems,and real physical environments are combined to create an independent“digital twin”world.In the field of int...With the advancement and maturation of digital technology,immersive experiences,virtual interactive systems,and real physical environments are combined to create an independent“digital twin”world.In the field of intelligent manufacturing,there is a growing need to explore and develop a new platform for practical teaching based on digital twins,in line with the intelligent,networked,and digital transformation of education.By analyzing the design elements of this platform,building various digital twin prototypes and environments,and developing a teaching and training platform for intelligent manufacturing based on digital twins,significant improvements can be achieved in efficiency.Therefore,this paper discusses the development of an intelligent manufacturing teaching and training platform based on digital twins,aiming to enrich both the form and content of intelligent manufacturing training.展开更多
The experiment platform of the aeroengine badly needs to develope in the direction of the overall supporting, the database system management and the engineering practice. Experimental means such as the water, electric...The experiment platform of the aeroengine badly needs to develope in the direction of the overall supporting, the database system management and the engineering practice. Experimental means such as the water, electricity and gas systems which support the operation of equipment, and multiple sets of engine components （the compressor, the turbine, the combustion chamber, the structural strength etc.） which support the experimental study of the engine also badly needs to improve in the direction of comprehensive monitoring and system integration to meet the needs of high efficient experiment and management. The experiment platform can make the experimental data and the experimental process be shared in different places in real time. Improving the collaborative ability of design and experiment, improving the automatic level of the experiment and so on all need the computer, the network and the professional and matching application system to support so as to guarantee the security, the stability and the reliability of the experiment, and reduce the risk of the experiment. This paper mainly discusses the main innovative exploration of experimental platform and equipment development about the current aeroengine.展开更多
With the development of education and technology,the construction of research public platforms has emerged as a critical initiative for many universities and top-tier public hospitals.The core and most fundamental fun...With the development of education and technology,the construction of research public platforms has emerged as a critical initiative for many universities and top-tier public hospitals.The core and most fundamental function of a basic public platform is to aggregate large instruments and specific resources,providing open services for instrumental analysis and sample testing.Optimized management and high-quality,efficient services are essential for such platforms.This article elucidates the construction of a research public platform in West China Hospital,focusing on the adoption of hierarchical management and precise services.The core of the hierarchical management lies in building a multi-level service platform composed of routine support platforms,advanced technology platforms,and specially qualification platforms,while establishing a talent hierarchy that differentiates between core and routine positions.This structure is designed to accurately meet the diverse needs of users and enhance resource efficiency.By implementing user access control with differentiated permissions for internal and external users and a dynamic credit-based review system,the laboratory can ensure safe and efficient operations.The four service modes—instrument usage,in-lab experiments,sample testing,and collaborative projects—are precisely aligned with various research scenarios.Proactive engagement with grant-funded projects,customized services for research groups,and a multidimensional training system further strengthen the platform's support for major scientific research tasks.Through systematic management and service innovation,this model achieves efficient integration and sustainable development of platform resources,providing a valuable reference for the construction of public platforms in similar medical institutions.展开更多
Once a train stops in a tunnel section and requires emergency evacuation,the large distance between stations and long walking distances in the underground spaces of suburban railway systems pose potential risks to the...Once a train stops in a tunnel section and requires emergency evacuation,the large distance between stations and long walking distances in the underground spaces of suburban railway systems pose potential risks to the evacuation process on tunnel platforms,especially in complex environments.This study utilized Virtual Reality(VR)technology to construct a virtual experimental platform for tunnel evacuation in suburban railway systems,simulating different combinations of smoke and obstacle conditions.By requiring participants to wear VR glasses and walk on an omnidirectional treadmill for moving,as well as complete psychological questionnaires,the study reveals the influences of No Guiding(NG)signs,Wall-Guided(WG)signs,and Central axis Guidance(CG)signs on the movement abilities and psychological behaviors of participants contrastively.The results show that either smoke conditions or obstacle positions affect the mental stress of participants,and the guidance sign has a positive effect on reducing the mental stress.There is an inverse relationship between mental stress and movement abilities.WG and CG signs respectively lead participants to walk closer to walls and along the central axis,which is conducive to reducing the variation in participants’behavior characteristics when circumventing obstacles on the wall side or track side under smoke conditions,respectively.Additionally,CG signs reduce the speed fluctuations of participants before circumventing obstacles,improving the stability of the distance from the wall and speed under smoke conditions,compared to NG and WG signs.These findings contribute to understanding the evacuation psychological-behavioral-movement characteristics of pedestrians on evacuation platforms in suburban railway tunnels and provide a basis for improving the safety design of evacuation guidance signs.展开更多
The development of information technology, especially the rise of online teaching platforms, has changed the way people read and the methods they use. Under this influence, primary school students’ independent readin...The development of information technology, especially the rise of online teaching platforms, has changed the way people read and the methods they use. Under this influence, primary school students’ independent reading has also been changed. However, due to limited self-control and understanding, primary school students face certain difficulties when using online teaching platforms for independent reading. Advantages and disadvantages of distance learning based on the network teaching platform were summarized in this paper. A one-year experiment study was carried out on our school fifth-grade students in independent reading using WeChat campus platform considering their current situation and existing problems of independent reading. In experiment study an independent reading mode was introduced. The results show that this reading mode can significantly improve students’ independent reading ability.展开更多
Experimental Design and Data Processing is an important core professional basic course for food science majors.This course is theoretical and practical,and there are many formulas,abstract contents and difficult to un...Experimental Design and Data Processing is an important core professional basic course for food science majors.This course is theoretical and practical,and there are many formulas,abstract contents and difficult to understand,and there are some problems in the teaching process,such as students1 poor interest in learning,insufficient mastery of what they have learned,and inability to combine theory with practice organically.Through analyzing the existing problems,this paper puts forward some reform measures for the teaching mode of experimental design and data processing by using the intelligent teaching of Superstar platform.展开更多
Wall slip is a microscopic phenomenon of cemented paste backfill(CPB)slurry near the pipe wall,which has an important influence on the form of slurry pipe transport flow and velocity distribution.Directly probing the ...Wall slip is a microscopic phenomenon of cemented paste backfill(CPB)slurry near the pipe wall,which has an important influence on the form of slurry pipe transport flow and velocity distribution.Directly probing the wall slip characteristics using conventional experimental methods is difficult.Therefore,this paper established a noncontact experimental platform for monitoring the microscopic slip layer of CPB pipeline transport independently based on particle image velocimetry(PIV)and analyzed the effects of slurry temperature,pipe diameter,solid concentration,and slurry flow on the wall slip velocity of the CPB slurry,which refined the theory of the effect of wall slip characteristics on pipeline transport.The results showed that the CPB slurry had an extensive slip layer at the pipe wall with significant wall slip.High slurry temperature improved the degree of particle Brownian motion within the slurry and enhanced the wall slip effect.Increasing the pipe diameter was not conducive to the formation of the slurry slip layer and led to a transition in the CPB slurry flow pattern.The increase in the solid concentration raised the interlayer shear effect of CPB slurry flow and the slip velocity.The slip velocity value increased from 0.025 to 0.056 m·s^(-1)when the solid content improved from 55wt%to 65wt%.When slurry flow increased,the CPB slurry flocculation structure changed,which affected the slip velocity,and the best effect of slip layer resistance reduction was achieved when the transported flow rate was 1.01 m^(3)·h^(-1).The results had important theoretical significance for improving the stability and economy of the CPB slurry in the pipeline.展开更多
文摘This study examined the development of technician teams on large-scale instrument platforms in universities,using the State Key Laboratory of Natural and Biomimetic Drugs in the Peking University School of Pharmaceutical Sciences as a case study.Data were collected through questionnaire surveys and interviews conducted in 2017,followed by a questionnaire survey in 2023,offering both subjective and objective insights.The evolution of the platform’s technician team over the past 5 years was analyzed,highlighting key experiences and identifying ongoing challenges.Recommendations to enhance technician team development include recruiting skilled faculty,clearly defining job responsibilities,and refining the assessment and incentive systems.
基金Basic Research Program of Jiangsu Province,Grant/Award Numbers:BK20221135,BK20243024,BM2022009National Key Research and Development Program of China,Grant/Award Number:2022YFC3003300+2 种基金National Natural Science Foundation of China,Grant/Award Numbers:42230704,42307202Young Elite Scientists Sponsorship Program by CAST,Grant/Award Number:2023QNRC001Xuzhou Science and Technology Program,Grant/Award Numbers:KC23383,KC23427。
文摘In March 2022,construction was started at Yunlong Lake Laboratory of Deep Underground Science and Engineering,China,on an underground gas storage experimental facility with the capacity to achieve composite structure design and material development.Underground gas storage can provide a solution to address the intermittency of renewable energy supply.Currently,lined rock caverns(LRCs)are regarded as the best option for compressed air and hydrogen storage,since they have excellent sealing properties and minimum environmental impacts.However,the load transfer,damage,and failure mechanisms of LRCs are not clear.This prevents the design and selection of mechanical structures.Particularly,the gas sealing capacity in specific gas conditions(e.g.,stored hydrogen-induced chemical reaction)remains poorly understood,and advanced materials to adapt the storage conditions of different gases should be developed.This experimental facility aims at providing a solution to these technical issues.This facility has several different types of LRCs,and study of the mechanical behavior of various structures and evaluation of the gas-tight performance of the sealing material can be carried out using a distributed fiberoptic sensing approach.The focus of this study is on the challenges in sealing material development and structure design.This facility facilitates large-scale and long-term energy storage for stable and continuous energy supply,and enables repurposing of underground space and acceleration of the realization of green energy ambitions in the context of Paris Agreement and China's carbon neutralization plan.
基金the Special Research Fund for the Ministry of Industry and Information Technology of China(No.MC-201620-H01-04)the Research and Development of Deep Water Semi-submersible Support Platform。
文摘With the rapid development of marine oil and gas exploitation,the evacuation of offshore platforms has received more attention.First,an experimental investigation of the evacuation process of 120 participants in a real offshore platform is performed,and then simulation results provided by Pathfinder are validated against the measurement results.Second,four typical evacuation scenarios on the platform referring to IMO guidelines are investigated by Pathfinder with the speed values achieved in experiments.The simulation results show that both the utilization of exits and evacuation efficiency of people on the offshore platform need to be further improved.Last,the evacuation routes of people under the four scenarios are optimized,and the improvement of the evacuation performance after the optimization is evaluated by several mathematical indicators.Final results show that the evacuation with the optimized route design prompts the use efficiency of exits and further reduces the evacuation time.The present study provides a useful advice for potentially revising the IMO guidelines in future and provides efficient evacuation strategies for planning the emergency evacuation on offshore platforms.
基金supported by National Natural Science Foundation of China(Nos.51476073,51266004)Natural Science Foundation of Gansu Province(No.138RJZA199).
文摘With the rapid development of urban rail transit,there have been an urgent problem of excessive stray current.Because the stray current distribution is random and difficult to verify in the field,we designed an improved stray current experimental platform by replacing the simulated aqueous solution with a real soil environment and by calculating the transition resistance by measuring the soil resistivity,which makes up for the defects in the previous references.Firstly,the mathematical models of rail-drainage net and rail-drainage netground were established,and the analytical expressions of current and voltage of rail,drainage net and other structures were derived.In addition,the simulation model was built,and the mathematical analysis results were compared with the simulation results.Secondly,the accuracy of the improved stray current experimental platform was verified by comparing the measured and simulation results.Finally,based on the experimental results,the influence factors of stray current were analyzed.The relevant conclusions provide experimental data and theoretical reference for the study of stray current in urban rail transit.
基金Supported by Undergraduate Teaching Research and Reform Project of University of Shanghai for Science and Technology in 2024(JGXM24281)University-Level First-Class Undergraduate Course Construction Project of University of Shanghai for Science and Technology in 2024(YLKC202424394).
文摘In view of the key role of undergraduate experimental teaching reform in cultivating high-quality talents with both innovative spirit and practical ability,this paper deeply discusses multi-dimensional reform strategies.Specifically,the teaching mode of"double teachers for every student"is innovatively introduced,and scientific research projects are deeply integrated into undergraduate experimental teaching,aiming at realizing the modern development of teaching content and the diversified expansion of teaching methods.By designing and applying the undergraduate experimental teaching platform for intelligent limb rehabilitation training based on the concept of"medical-engineering interdisciplinary crossing",it not only builds a bridge for students to contact cutting-edge scientific research and strengthen practical skills,but also provides valuable ideas and practical models for the innovation of undergraduate experimental teaching.In the future,with the continuous optimization and upgrading of platform functions,it is expected to provide students with a richer and richer learning experience and comprehensively promote students'overall quality.
文摘With the advancement of vocational education reform,education informationization,and digitalization have become the important direction of the reform of electrical and electronic teaching in high vocational colleges.In this context,intelligent product development of professional electrical and electronic teaching should also do a good job in practice and innovation,especially in actively building a digital experimental teaching platform and promoting the reform of experimental teaching mode,so that students can learn more useful knowledge and skills in the new platform,and cultivate more applied and skilled talents for society.While analyzing the problems existing in the traditional electrical and electronic experimental teaching mode,this paper analyzes the significance and practical path of the construction of electrical and electronic experimental teaching platforms in higher vocational colleges which can be of reference in future research.
文摘In recent years, attention has been focused on the spar platform for gas and oil exploitation in deep water. With the development of offshore technology, many new spar concepts have been put forward and fully studied. This paper presents the results of an experimental investigation on the hydrodynamic behavior of a new spar concept from Novellent Offshore LLC, USA, which is called Ceometrie Spar （G-spar）. A new type of buoyancy can concept from the same company, viz. Integratod Buoyancy Can （IBC）, is researched in the meantime. The G-spar and IBC models with a 1：70 scale are tested in the State Key Laboratory of Ocean Engineering at Shanghai Jiao Tong University for the global performance of the spar hull, in which the second-order wave drift force is involved, as well as the effect of heave plates on the motion characteristics and mooring force of the G-spar platform.
基金supported by the grants from the National Natural Science Foundation of China(Nos.81973251 and 81302725)Hebei Province Funding Project for Introduced Overseas Personnel(Nos.C20230351 and C20220345)+3 种基金Key Research and Development Program of Hebei Province(No.22372701D)Hebei Province Natural Science Fund(No.H2020206610)Hebei Provincial Health Commission Government-Funded Clinical Medicine Talent Program(No.ZF2024048)Hebei Medical University Undergraduate Innovative Experiment Program(No.USIP2023008)。
文摘The combination of nucleic acid and small-molecule drugs in tumor treatment holds significant promise;however,the precise delivery and controlled release of drugs within the cytoplasm encounter substantial obstacles,impeding the advancement of formulations.To surmount the challenges associated with precise drug delivery and controlled release,we have developed a multi-level p H-responsive co-loaded drug lipid nanoplatform.This platform first employs cyclic cell-penetrating peptides to exert a multi-level pH response,thereby enhancing the uptake efficiency of tumor cells and endow the nanosystem with effective endosomal/lysosomal escape.Subsequently,small interferring RNA(siRNA)complexes are formed by compacting siRNA with stearic acid octahistidine,which is capable of responding to the lysosome-tocytoplasm pH gradient and facilitate siRNA release.The siRNA complexes and docetaxel are simultaneously encapsulated into liposomes,thereby creating a lipid nanoplatform capable of co-delivering nucleic acid and small-molecule drugs.The efficacy of this platform has been validated through both in vitro and in vivo experiments,affirming its significant potential for practical applications in the co-delivery of nucleic acids and small-molecule drugs.
基金financially supported by the Special Project for Marine Renewable Energy (No. GHME2016YY02)the National Key R&D Program of China (No. 2018YFB 1501900)+1 种基金the Shandong Provincial Natural Science Key Basic Program (No. ZR2017ZA0202)the Qingdao Municipal Science & Technology Program (No. 15-8-3-7jch)
文摘To take advantage of the abundance of both fishery and wave energy resources in offshore sea areas,a novel floating platform with a heaving buoy-based wave energy converter(WEC)assembled with a set of net cages is presented in this work.The floating WEC system provides a power supply,while the net cages are used for aquaculture.It is designed to have an independent and self-operation breeding function.An experimental study is carried out to investigate the hydrodynamic performance of the device in a wave tank considering the factors of net cages,draft depth,and power take-off,and results show that these variables have significant effects on wave energy capture.Incident waves with short periods cause intense interactions that allow the device to undergo large relative motion.The draft depth could be determined according to wave period rather than wave height.This study also explores the response amplitude operator of the device and determines its resonance scope.The experimental results could provide reliable information for future studies on phase differences and the design of two-body WECs.
基金Supported by the National Natural Science Foundation of China （NSFC-5060900）.
文摘Magnetorheological （MR） dampers have been proposed to control the vibration of offshore platforms in this paper. The semi-active control strategy based on fuzzy control algorithm was adopted to determine the optimal output control force based on the responses of jacket platforms. A typical jacket platform in Mexico Gulf was selected as the numerical example to investigate the effectiveness of the proposed control method. Furthermore, a model experiment was performed to validate the results of the numerical simulation. The experimental model of the jacket platform was designed based on dynamical similarity criterion by the scale of 1：50. Both of the numerical and experimental results show that the semi-active control system with the MR damper can reduce vibrations of jacket platforms effectively and at the same time the control effect is stable.
基金supported by the National Natural Science Foundation of China (Grant Nos.60605028, 50975168)National Hi-tech Research and Development Program of China (Grant Nos.2007AA04Z225, 2009AA04Z211)+1 种基金Program for Excellent Young Teachers of Shanghai (Grant Nos.07Q14024,07QH14006)Shuguang Program of Shanghai (Grant No.07SG47)
文摘A control model of binocular vergence eye movements is presented. The control model can reduce blind areas caused by the double cameras in motion platform. In order to validate the model performance, an experimental platform and its control system based on TMS320LF2407 are designed. The control system has its compacted configuration and high reliability. The simulation and experimental results show that the control system can realize binocular vergence movements. Compared with the conventional moving double cameras system, this new system can considerably reduce blind areas.
文摘Practice training is very important for students learning Computer networks.But building a real laboratory is constrained and expensive.In this paper,we present an online experimental platform for computer networks course based on Dynamips simulator.Instructors and students can access the platform by IE Browser to manage and take router experiments.On the basis of deployment and testing,the platform is effective and flexible.
基金Supported by Harbin Talents of Science and Technology Innovation Special Fund(2011RFQXG021)
文摘Experiments involving a sonar platform with a sound absorption wedge were carried out for the purpose of obtaining the low frequency acoustic characteristics. Acoustic characteristics of a sonar platform model with a sound absorption wedge were measured, and the effects of different wedge laid areas on platform acoustic characteristic were tested. Vibration acceleration and self-noise caused by model vibration were measured in four conditions: 0%, 36%, 60%, and 100% of wedge laid area when the sonar platform was under a single frequency excitation force. An experiment was performed to validate a corresponding numerical calculation. The numerical vibration characteristics of platform area were calculated by the finite element method, and self-noise caused by the vibration in it was predicted by an experiential formula. The conclusions prove that the numerical calculation method can partially replace the experimental process for obtaining vibration and sound characteristics.
文摘With the advancement and maturation of digital technology,immersive experiences,virtual interactive systems,and real physical environments are combined to create an independent“digital twin”world.In the field of intelligent manufacturing,there is a growing need to explore and develop a new platform for practical teaching based on digital twins,in line with the intelligent,networked,and digital transformation of education.By analyzing the design elements of this platform,building various digital twin prototypes and environments,and developing a teaching and training platform for intelligent manufacturing based on digital twins,significant improvements can be achieved in efficiency.Therefore,this paper discusses the development of an intelligent manufacturing teaching and training platform based on digital twins,aiming to enrich both the form and content of intelligent manufacturing training.
文摘The experiment platform of the aeroengine badly needs to develope in the direction of the overall supporting, the database system management and the engineering practice. Experimental means such as the water, electricity and gas systems which support the operation of equipment, and multiple sets of engine components （the compressor, the turbine, the combustion chamber, the structural strength etc.） which support the experimental study of the engine also badly needs to improve in the direction of comprehensive monitoring and system integration to meet the needs of high efficient experiment and management. The experiment platform can make the experimental data and the experimental process be shared in different places in real time. Improving the collaborative ability of design and experiment, improving the automatic level of the experiment and so on all need the computer, the network and the professional and matching application system to support so as to guarantee the security, the stability and the reliability of the experiment, and reduce the risk of the experiment. This paper mainly discusses the main innovative exploration of experimental platform and equipment development about the current aeroengine.
基金supported by Sichuan University AI-Driven In-novative Experimental Technology Research Project(SCU2025047).
文摘With the development of education and technology,the construction of research public platforms has emerged as a critical initiative for many universities and top-tier public hospitals.The core and most fundamental function of a basic public platform is to aggregate large instruments and specific resources,providing open services for instrumental analysis and sample testing.Optimized management and high-quality,efficient services are essential for such platforms.This article elucidates the construction of a research public platform in West China Hospital,focusing on the adoption of hierarchical management and precise services.The core of the hierarchical management lies in building a multi-level service platform composed of routine support platforms,advanced technology platforms,and specially qualification platforms,while establishing a talent hierarchy that differentiates between core and routine positions.This structure is designed to accurately meet the diverse needs of users and enhance resource efficiency.By implementing user access control with differentiated permissions for internal and external users and a dynamic credit-based review system,the laboratory can ensure safe and efficient operations.The four service modes—instrument usage,in-lab experiments,sample testing,and collaborative projects—are precisely aligned with various research scenarios.Proactive engagement with grant-funded projects,customized services for research groups,and a multidimensional training system further strengthen the platform's support for major scientific research tasks.Through systematic management and service innovation,this model achieves efficient integration and sustainable development of platform resources,providing a valuable reference for the construction of public platforms in similar medical institutions.
基金supported by the National Natural Science Foundation of China(Grant Number 52472322)the Shanghai Sailing Program(Grant Number 21YF1415800)+1 种基金the Open Project of Key Laboratory of Advanced Public Transportation Science(Grant Number 2023-APTS-05)the Shanghai SASAC Enterprise Innovation and Capability Enhancement Project(Grant Number 2022016,2023020).
文摘Once a train stops in a tunnel section and requires emergency evacuation,the large distance between stations and long walking distances in the underground spaces of suburban railway systems pose potential risks to the evacuation process on tunnel platforms,especially in complex environments.This study utilized Virtual Reality(VR)technology to construct a virtual experimental platform for tunnel evacuation in suburban railway systems,simulating different combinations of smoke and obstacle conditions.By requiring participants to wear VR glasses and walk on an omnidirectional treadmill for moving,as well as complete psychological questionnaires,the study reveals the influences of No Guiding(NG)signs,Wall-Guided(WG)signs,and Central axis Guidance(CG)signs on the movement abilities and psychological behaviors of participants contrastively.The results show that either smoke conditions or obstacle positions affect the mental stress of participants,and the guidance sign has a positive effect on reducing the mental stress.There is an inverse relationship between mental stress and movement abilities.WG and CG signs respectively lead participants to walk closer to walls and along the central axis,which is conducive to reducing the variation in participants’behavior characteristics when circumventing obstacles on the wall side or track side under smoke conditions,respectively.Additionally,CG signs reduce the speed fluctuations of participants before circumventing obstacles,improving the stability of the distance from the wall and speed under smoke conditions,compared to NG and WG signs.These findings contribute to understanding the evacuation psychological-behavioral-movement characteristics of pedestrians on evacuation platforms in suburban railway tunnels and provide a basis for improving the safety design of evacuation guidance signs.
文摘The development of information technology, especially the rise of online teaching platforms, has changed the way people read and the methods they use. Under this influence, primary school students’ independent reading has also been changed. However, due to limited self-control and understanding, primary school students face certain difficulties when using online teaching platforms for independent reading. Advantages and disadvantages of distance learning based on the network teaching platform were summarized in this paper. A one-year experiment study was carried out on our school fifth-grade students in independent reading using WeChat campus platform considering their current situation and existing problems of independent reading. In experiment study an independent reading mode was introduced. The results show that this reading mode can significantly improve students’ independent reading ability.
基金The foundation for Teaching Research Project of Hubei University of Technology in Hubei Province in 2020(grant number 2020017).
文摘Experimental Design and Data Processing is an important core professional basic course for food science majors.This course is theoretical and practical,and there are many formulas,abstract contents and difficult to understand,and there are some problems in the teaching process,such as students1 poor interest in learning,insufficient mastery of what they have learned,and inability to combine theory with practice organically.Through analyzing the existing problems,this paper puts forward some reform measures for the teaching mode of experimental design and data processing by using the intelligent teaching of Superstar platform.
基金financially supported by the National Natural Science Foundation of China (Nos.51774137 and 51804121)。
文摘Wall slip is a microscopic phenomenon of cemented paste backfill(CPB)slurry near the pipe wall,which has an important influence on the form of slurry pipe transport flow and velocity distribution.Directly probing the wall slip characteristics using conventional experimental methods is difficult.Therefore,this paper established a noncontact experimental platform for monitoring the microscopic slip layer of CPB pipeline transport independently based on particle image velocimetry(PIV)and analyzed the effects of slurry temperature,pipe diameter,solid concentration,and slurry flow on the wall slip velocity of the CPB slurry,which refined the theory of the effect of wall slip characteristics on pipeline transport.The results showed that the CPB slurry had an extensive slip layer at the pipe wall with significant wall slip.High slurry temperature improved the degree of particle Brownian motion within the slurry and enhanced the wall slip effect.Increasing the pipe diameter was not conducive to the formation of the slurry slip layer and led to a transition in the CPB slurry flow pattern.The increase in the solid concentration raised the interlayer shear effect of CPB slurry flow and the slip velocity.The slip velocity value increased from 0.025 to 0.056 m·s^(-1)when the solid content improved from 55wt%to 65wt%.When slurry flow increased,the CPB slurry flocculation structure changed,which affected the slip velocity,and the best effect of slip layer resistance reduction was achieved when the transported flow rate was 1.01 m^(3)·h^(-1).The results had important theoretical significance for improving the stability and economy of the CPB slurry in the pipeline.
