The key parameters that characterize the morphological quality of multi-layer and multi-pass metal laser deposited parts are the surface roughness and the error between the actual printing height and the theoretical m...The key parameters that characterize the morphological quality of multi-layer and multi-pass metal laser deposited parts are the surface roughness and the error between the actual printing height and the theoretical model height.The Taguchi method was employed to establish the correlations between process parameter combinations and multi-objective characterization of metal deposition morphology(height error and roughness).Results show that using the signal-to-noise ratio and grey relational analysis,the optimal parameter combination for multi-layer and multi-pass deposition is determined as follows:laser power of 800 W,powder feeding rate of 0.3 r/min,step distance of 1.6 mm,and scanning speed of 20 mm/s.Subsequently,a Genetic Bayesian-back propagation(GB-BP)network is constructed to predict multi-objective responses.Compared with the traditional back propagation network,the GB-back propagation network improves the prediction accuracy of height error and surface roughness by 43.14%and 71.43%,respectively.This network can accurately predict the multi-objective characterization of morphological quality of multi-layer and multi-pass metal deposited parts.展开更多
In this study,polyacrylic acid(PAA)films were employed as a model system,and a series of PAA films with tunable water wettability was systematically prepared by varying molecular weight and curing temperature.Using at...In this study,polyacrylic acid(PAA)films were employed as a model system,and a series of PAA films with tunable water wettability was systematically prepared by varying molecular weight and curing temperature.Using attenuated total reflectance Fourier-transform infrared spectroscopy(ATR-FTIR),the molecular configurations of surface carboxyl groups(COOH),free carboxyl(COOH_(f))and hydrogen-bonded carboxyl(COOH_(HB),were directly correlated with the polar component of surface energy(γ^(s,p)).By decomposing theγ^(s,p)values of the PAA thin films as a sum of the contributions of COOH_(f)and COOH_(H B),the intrinsic polar component of surface energy of COOH_(H B)(γ_(H B)^(s,p*))was quantified for the first time as 8.34 mN/m,significantly lower than that of COOH_(f)(γ_(f)^(s,p*)=34 mN/m).This result highlights that hydrogen bonding markedly reduces theγ^(s,p),providing a rational explanation for the relatively large water contact angle observed on PAA thin films.Furthermore,it establishes a thermodynamic basis for estimating the fraction of surface COOH_(H B)groups(f H B)from wettability measurements.Further extension of the model to carboxyl-terminated self-assembled monolayers(COOH-SAMs)revealed that surface COOH density(ΣCOOH)critically regulates wetting behavior:whenΣCOOH ranges from 4.30 to 5.25 nm^(-2),COOH groups predominantly exist in a free state and facilitate effective hydration layers,thereby promoting superhydrophilicity.Overall,this study not only establishes a unified thermodynamic framework linking surface COOH configurations to macroscopic wettability,but also validates its universality by extending it to COOH-SAMs systems,thereby providing a unified theoretical framework for the controllable design of hydrophilicity in various COOH-functionalized surfaces.展开更多
Owing to their intricate molecular frameworks and copious chiral centers,the structural identification and configurational assignment of natural products are challenging tasks.Comprehensive spectral data analysis is c...Owing to their intricate molecular frameworks and copious chiral centers,the structural identification and configurational assignment of natural products are challenging tasks.Comprehensive spectral data analysis is crucial for the confirmation of absolute configurations.Ignoring critical parameters will lead to false structure,which may confuse the total synthesis and drug development.Herein,the configurations of seven heterogeneous Pallavicinia diterpenoids(PDs) isolated from Pallavicinia liverworts are revised using a combination of single-crystal X-ray diffraction and electronic circular dichroism(ECD) calculations.Meanwhile,identification of five unprecedented PD heterodimers PD-dimers A-E(18-22) along with eleven previously undescribed PDs(5-9,13-17,23) obtained by the reinvestigation of the Chinese liverwort Pallavicinia subciliata have resulted in corrections and support the revised conclusions.展开更多
The precise tuning of magnetic nanoparticle size and magnetic domains,thereby shaping magnetic properties.However,the dynamic evolution mechanisms of magnetic domain configurations in relation to electromagnetic(EM)at...The precise tuning of magnetic nanoparticle size and magnetic domains,thereby shaping magnetic properties.However,the dynamic evolution mechanisms of magnetic domain configurations in relation to electromagnetic(EM)attenuation behavior remain poorly understood.To address this gap,a thermodynamically controlled periodic coordination strategy is proposed to achieve precise modulation of magnetic nanoparticle spacing.This approach unveils the evolution of magnetic domain configurations,progressing from individual to coupled and ultimately to crosslinked domain configurations.A unique magnetic coupling phenomenon surpasses the Snoek limit in low-frequency range,which is observed through micromagnetic simulation.The crosslinked magnetic configuration achieves effective low-frequency EM wave absorption at 3.68 GHz,encompassing nearly the entire C-band.This exceptional magnetic interaction significantly enhances radar camouflage and thermal insulation properties.Additionally,a robust gradient metamaterial design extends coverage across the full band(2–40 GHz),effectively mitigating the impact of EM pollution on human health and environment.This comprehensive study elucidates the evolution mechanisms of magnetic domain configurations,addresses gaps in dynamic magnetic modulation,and provides novel insights for the development of high-performance,low-frequency EM wave absorption materials.展开更多
At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass components.In this study,multi-laye...At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass components.In this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool head.The material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum alloys.The results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center area.Repeated friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped zone.The tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition sample.It is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping area.The multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.展开更多
In the context of the“dual carbon”goals,to address issues such as high energy consumption,high costs,and low power quality in the rapid development of electrified railways,this study focused on the China Railways Hi...In the context of the“dual carbon”goals,to address issues such as high energy consumption,high costs,and low power quality in the rapid development of electrified railways,this study focused on the China Railways High-Speed 5 Electric Multiple Unit and proposed a mathematical model and capacity optimization method for an onboard energy storage system using lithium batteries and supercapacitors as storage media.Firstly,considering the electrical characteristics,weight,and volume of the storage media,a mathematical model of the energy storage system was established.Secondly,to tackle problems related to energy consumption and power quality,an energy management strategy was proposed that comprehensively considers peak shaving and valley filling and power quality by controlling the charge/discharge thresholds of the storage system.Thecapacity optimization adopted a bilevel programming model,with the series/parallel number of storage modules as variables,considering constraints imposed by the Direct Current to Direct Current converter,train load,and space.An improved Particle Swarm Optimization algorithm and linear programming solver were used to solve specific cases.The results show that the proposed onboard energy storage system can effectively achieve energy savings,reduce consumption,and improve power qualitywhile meeting the load and space limitations of the train.展开更多
Dense cropping increases crop yield but intensifies resource competition,which reduces single plant yield and limits potential yield growth.Optimizing canopy spacing could enhance resource utilization,support crop mor...Dense cropping increases crop yield but intensifies resource competition,which reduces single plant yield and limits potential yield growth.Optimizing canopy spacing could enhance resource utilization,support crop morphological development and increase yield.Here,a three-year study was performed to verify the feasibility of adjusting row spacing to further enhance yield in densely planted soybeans.Of three row-spacing configurations(40-40,20-40,and 20-60 cm)and two planting densities(normal 180,000 plants ha 1 and high 270,000 plants ha 1).The differences in canopy structure,plant morphological development,photosynthetic capacity and their impact on yield were analyzed.Row spacing configurations have a significant effect on canopy transmittance(CT).The 20-60 cm row spacing configuration increased CT and creates a favorable canopy light environment,in which plant height is reduced,while branching is promoted.This approach reduces plant competition,optimizes the developments of leaf area per plant,specific leaf area,leaf area development rate,leaf area duration and photosynthetic physiological indices(F_(v)/F_(m),ETR,P_(n)).The significant increase of 11.9%-34.2%in canopy apparent photosynthesis(CAP)is attributed to the significant optimization of plant growth and photosynthetic physiology through CT,an important contributing factor to yield increases.The yield in the 20-60 cm treatment is 4.0%higher than in equidistant planting under normal planting density,but 5.9%under high density,primarily driven by CAP and pod number.These findings suggest that suitable row spacing configurations optimize the light environment for plants,promote source-sink transformation in soybeans,and further improve yield.In practice,a 20-60 cm row spacing configuration could be employed for high-density soybean planting to achieve a more substantial yield gain.展开更多
Recent advances in earth science and exploration have made deepwater channel-levee systems a research focus.We collected and analyzed over 10000 km of two-dimensional multichannel seismic data from the offshore Indus ...Recent advances in earth science and exploration have made deepwater channel-levee systems a research focus.We collected and analyzed over 10000 km of two-dimensional multichannel seismic data from the offshore Indus Basin to identify channellevee systems at various hierarchical levels depending on their seismic reflection characteristics.Seismic facies analysis was integrated with well data to map the spatial distribution of channel-levee systems in the offshore Indus Basin across various geological periods,and the factors influencing their development were discussed.These systems within the basin were identified using a developed,refined three-tier classification method.The first-order system consists of multiple spatially stacked complexes,the second-order system continuously developed multistage channel-levee bodies,and the third-order system represents the smallest identifiable sedimentary units on seismic profiles.Our findings demonstrate the evolution of the offshore Indus Basin from a single-stage channel with lateral migration to multistage vertical channel stacking from the Miocene to the Pleistocene.Tectonic activities exert their effect on channel-levee systems through their influence on the relative sea level.They also trigger volcanic or seismic events and affect siliciclastic supply.Warm and humid climate conditions form large river systems,which aid in the transport of terrestrial debris to the basin margin.Most channel-levee systems are assumed to have formed during low sea-level periods.This study offers new insights into the formation and evolution of turbidite sedimentary systems in the offshore Indus Basin and presents a practical classification method for comprehending gravity-flow sedimentary configurations and deepwater hydrocarbon exploration.展开更多
The influence of geometric configuration on the friction characteristics during incremental sheet forming of AA5052 was analyzed by integrating surface morphology and its characteristic parameters,along with plastic s...The influence of geometric configuration on the friction characteristics during incremental sheet forming of AA5052 was analyzed by integrating surface morphology and its characteristic parameters,along with plastic strain,contact pressure,and area.The interface promotes lubrication and support when wall angles were≤40°,a 0.5 mm-thin sheet was used,and a 10 mm-large tool radius was employed.This mainly results in micro-plowing and plastic extrusion flow,leading to lower friction coefficient.However,when wall angles exceed 40°,significant plastic strain roughening occurs,leading to inadequate lubrication on the newly formed surface.Increased sheet thickness and decreased tool radius elevate contact pressure.These actions trigger micro-cutting and adhesion,potentially leading to localized scuffing and dimple tears,and higher friction coefficient.The friction mechanisms remain unaffected by the part’s plane curve features.As the forming process progresses,abrasive wear intensifies,and surface morphology evolves unfavorably for lubrication and friction reduction.展开更多
The field-reversed configuration(FRC)plasma thruster driven by rotating magnetic field(RMF),abbreviated as the RMF-FRC thruster,is a new type of electric propulsion technology that is expected to accelerate the deep s...The field-reversed configuration(FRC)plasma thruster driven by rotating magnetic field(RMF),abbreviated as the RMF-FRC thruster,is a new type of electric propulsion technology that is expected to accelerate the deep space exploration.An experimental prototype,including diagnostic devices,was designed and constructed based on the principles of the RMF-FRC thruster,with an RMF frequency of 210 kHz and a maximum peak current of 2 kA.Under the rated operating conditions,the initial plasma density was measured to be 5×10^(17)m^(-3),and increased to 2.2×10^(19)m^(-3)after the action of RMF.The coupling efficiency of RMF was about 53%,and the plasma current reached 1.9 kA.The axial magnetic field changed in reverse by 155 Gauss,successfully reversing the bias magnetic field of 60 Gauss,which verifies the formation of FRC plasma.After optimization research,it was found that when the bias magnetic field is 100 Gauss,the axial magnetic field reverse variation caused by FRC is the highest at 164 Gauss.The experimental results are discussed and strategies are proposed to improve the performance of the prototype.展开更多
Hydroxyapatite nanoparticles(HAP NPs)were synthesized by a one‐step hydrothermal method.The surface of HAP NPs was grafted-SH and-COOH chelating groups via in situ surface‐modification with iminodiacetic acid(IDA)an...Hydroxyapatite nanoparticles(HAP NPs)were synthesized by a one‐step hydrothermal method.The surface of HAP NPs was grafted-SH and-COOH chelating groups via in situ surface‐modification with iminodiacetic acid(IDA)and 3‐mercaptopropyl trimethoxysilane(MPS)to afford dual surface‐capped nano‐amendment HAPIDA/MPS.The structure of HAP‐IDA/MPS was characterized,and its adsorption performance for Hg^(2+),Cu^(2+),Zn^(2+),Ni^(2+),Co^(2+),and Cd^(2+)was evaluated.The total adsorption capacity of 0.10 g HAP‐IDA/MPS nano‐amendment for Hg^(2+),Cu^(2+),Zn^(2+),Ni^(2+),Co^(2+),and Cd^(2+)with an initial mass concentration of 20 mg·L^(-1) reached 13.7 mg·g^(-1),about 4.3 times as much as that of HAP.Notably,HAP‐IDA/MPS nano‐amendment displayed the highest immobilization rate for Hg^(2+),possibly because of its chemical reaction with-SH to form sulfide,possessing the lowest solubility product constant among a variety of metal sulfides.展开更多
This paper investigates the configuration design associated with boundary-constrained swarm flying.An analytic swarm configuration is identified to ensure the passive safety between each pair of spacecraft in the radi...This paper investigates the configuration design associated with boundary-constrained swarm flying.An analytic swarm configuration is identified to ensure the passive safety between each pair of spacecraft in the radial-cross-track plane.For the first time,this work derives the explicit configurable spacecraft amount to clarify the configuration's accommodation capacity while considering the maximum inter-spacecraft separation constraint.For larger-scale design problem that involves hundreds of spacecraft,this paper proposes an optimization framework that integrates a Relative Orbit Element(ROE)affine transformation operation and successional convex optimization.The framework establishes a multi-subcluster swarm structure,allowing decoupling the maintenance issues of each subcluster.Compared with previous design methods,it ensures that the computational cost for constraints verification only scales linearly with the swarm size,while also preserving the configuration optimization capacities.Numerical simulations demonstrate that the proposed analytic configuration strictly meets the design constraints.It is also shown that the proposed framework reduces the handled constraint amount by two orders compared with direct optimization,while achieving a remarkable swarm safety enhancement based on the existing analytic configuration.展开更多
With the continuous application of new technologies in reconnaissance and attack, false camouflage plays a more important role in improving the survivability of targets, and the number of decoys plays a crucial role i...With the continuous application of new technologies in reconnaissance and attack, false camouflage plays a more important role in improving the survivability of targets, and the number of decoys plays a crucial role in the camouflaging effect. Based on the concept of cost-effectiveness ratio, according to the newly formulated Johnson criterion and the view of discovery and destruction, this paper proposes to take the identification probability as the probability of being destroyed and uses mathematical formulas to calculate the cost of a single use decoy. On this basis, a cost-effectiveness ratio model is established, with the product of the increase in the survival probability of the target and the cost of the target as the benefit, and the sum of the product of the probability of being destroyed and the cost of the decoy and the cost of a single use as the consumption cost. The model is calculated and analyzed, and the number of decoys that conform to the actual situation is obtained.展开更多
With the increase in the quantity and scale of Static Random-Access Memory Field Programmable Gate Arrays (SRAM-based FPGAs) for aerospace application, the volume of FPGA configuration bit files that must be stored ha...With the increase in the quantity and scale of Static Random-Access Memory Field Programmable Gate Arrays (SRAM-based FPGAs) for aerospace application, the volume of FPGA configuration bit files that must be stored has increased dramatically. The use of compression techniques for these bitstream files is emerging as a key strategy to alleviate the burden on storage resources. Due to the severe resource constraints of space-based electronics and the unique application environment, the simplicity, efficiency and robustness of the decompression circuitry is also a key design consideration. Through comparative analysis current bitstream file compression technologies, this research suggests that the Lempel Ziv Oberhumer (LZO) compression algorithm is more suitable for satellite applications. This paper also delves into the compression process and format of the LZO compression algorithm, as well as the inherent characteristics of configuration bitstream files. We propose an improved algorithm based on LZO for bitstream file compression, which optimises the compression process by refining the format and reducing the offset. Furthermore, a low-cost, robust decompression hardware architecture is proposed based on this method. Experimental results show that the compression speed of the improved LZO algorithm is increased by 3%, the decompression hardware cost is reduced by approximately 60%, and the compression ratio is slightly reduced by 0.47%.展开更多
Through on-site investigations and case analyses of green mines in Huizhou City,and by integrating technical measures including soil improvement,plant configuration,and community construction,this study proposes a pla...Through on-site investigations and case analyses of green mines in Huizhou City,and by integrating technical measures including soil improvement,plant configuration,and community construction,this study proposes a plant configuration model tailored for ecological restoration in the mining areas of Huizhou.The implementation of a multi-level configuration model that predominantly employs native plant species,combined with a"soil-vegetation-microorganism"collaborative restoration strategy,can significantly enhance vegetation coverage in mining areas,increase soil organic matter content,and reduce the bioavailability of heavy metals in the soil.Based on field research and case study analyses,several optimization recommendations are proposed from the perspectives of slope stability and soil and water conservation.Ultimately,it summarizes plant configuration models and their application effects in the ecological restoration of green mines in Huizhou City.These findings may serve as valuable references for the ecological restoration of mines in South China.展开更多
The huge impact kinetic energy cannot be quickly dissipated by the energy-absorbing structure and transferred to the other vehicle through the car body structure,which will cause structural damage and threaten the liv...The huge impact kinetic energy cannot be quickly dissipated by the energy-absorbing structure and transferred to the other vehicle through the car body structure,which will cause structural damage and threaten the lives of the occupants.Therefore,it is necessary to understand the laws of energy conversion,dissipation and transfer during train collisions.This study proposes a multi-layer progressive analysis method of energy flow during train collisions,considering the characteristics of the train.In this method,the train collision system is divided into conversion,dissipation,and transfer layers from the perspective of the train,collision interface,and car body structure to analyze the energy conversion,dissipation and transfer characteristics.Taking the collision process of a rail train as an example,a train collision energy transfer path analysis model was established based on power flow theory.The results show that when the maximum mean acceleration of the vehicle meets the standard requirements,the jerk may exceed the allowable limit of the human body,and there is a risk of injury to the occupants of a secondary collision.The decay rate of the collision energy along the direction of train operation reaches 79%.As the collision progresses,the collision energy gradually converges in the structure with holes,and the structure deforms when the gathered energy is greater than the maximum energy the structure can withstand.The proposed method helps to understand the train collision energy flow law and provides theoretical support for the train crashworthiness design in the future.展开更多
A substation is a complex coupled system composed of various electrical equipment.Compared with standalone equipment,there is a significant coupling effect in the seismic response of interconnected equipment.To addres...A substation is a complex coupled system composed of various electrical equipment.Compared with standalone equipment,there is a significant coupling effect in the seismic response of interconnected equipment.To address this issue,this study investigates the seismic interaction of substation equipment with multiple electrical configurations and proposes an improved seismic design method.First,the concept of the coupling coefficient is introduced,which is used to improve the Newmark-βmethod and response spectrum method for the seismic design of standalone equipment.Then,the finite element models of a substation system with multiple configurations are established,and the vibration characteristics and seismic responses of the interconnected equipment are investigated.Finally,the coupling coefficients are obtained by kernel density estimation of the response results under twenty seismic ground motions,and the effectiveness of the proposed method is verified through two numerical examples.The results show that the frequency coupling coefficients vary from 0.69 to 1.42,while the seismic action coupling coefficient has a wider range,changing from 1.04 to 3.91.The coupling effect amplifies the seismic response of higher-frequency equipment,and the amplification degree varies among different configurations for the same type of equipment.展开更多
The growing incidence of cyberattacks necessitates a robust and effective Intrusion Detection Systems(IDS)for enhanced network security.While conventional IDSs can be unsuitable for detecting different and emerging at...The growing incidence of cyberattacks necessitates a robust and effective Intrusion Detection Systems(IDS)for enhanced network security.While conventional IDSs can be unsuitable for detecting different and emerging attacks,there is a demand for better techniques to improve detection reliability.This study introduces a new method,the Deep Adaptive Multi-Layer Attention Network(DAMLAN),to boost the result of intrusion detection on network data.Due to its multi-scale attention mechanisms and graph features,DAMLAN aims to address both known and unknown intrusions.The real-world NSL-KDD dataset,a popular choice among IDS researchers,is used to assess the proposed model.There are 67,343 normal samples and 58,630 intrusion attacks in the training set,12,833 normal samples,and 9711 intrusion attacks in the test set.Thus,the proposed DAMLAN method is more effective than the standard models due to the consideration of patterns by the attention layers.The experimental performance of the proposed model demonstrates that it achieves 99.26%training accuracy and 90.68%testing accuracy,with precision reaching 98.54%on the training set and 96.64%on the testing set.The recall and F1 scores again support the model with training set values of 99.90%and 99.21%and testing set values of 86.65%and 91.37%.These results provide a strong basis for the claims made regarding the model’s potential to identify intrusion attacks and affirm its relatively strong overall performance,irrespective of type.Future work would employ more attempts to extend the scalability and applicability of DAMLAN for real-time use in intrusion detection systems.展开更多
Solution environment can influence the flexible structure of DNA under specific conditions,thereby affecting the stability of nucleic acids and ultimately impacting critical biological processes such as replication an...Solution environment can influence the flexible structure of DNA under specific conditions,thereby affecting the stability of nucleic acids and ultimately impacting critical biological processes such as replication and transcription.Intracellular solution environment is variable,and previous studies have demonstrated that it can enhance the stability of DNA structures under certain circumstances.In this work,molecular dynamics simulations were conducted on B-DNA(1ZEW,with a nucleotide sequence of CCTCTAGAGG)derived from human breast cancer cells(MDA-MB231)to explore the effects of ethanol solution on DNA configuration transformation at different temperatures and concentrations.The calculated results indicate that ethanol facilitates the transition of 1ZEW from B-DNA to A-DNA at lower temperature.Furthermore,it is observed that temperature affects DNA structure to some extent,thereby modifying the trend in DNA configuration transformation.At low temperatures,the ethanol can promote the transformation of B-DNA into A-DNA at higher concentrations.While at higher temperatures,the DNA could be in a state of thermal melting.These conclusions presented here can give valuable insights into how ethanol affects B-DNA configuration transformations.展开更多
Two novel diketopiperazines(1 and 5),along with ten known compounds(2−4,6−12)demonstrating significant skin inflammation inhibition,were isolated from a marine-derived fungus identified as Aspergillus sp.FAZW0001.The ...Two novel diketopiperazines(1 and 5),along with ten known compounds(2−4,6−12)demonstrating significant skin inflammation inhibition,were isolated from a marine-derived fungus identified as Aspergillus sp.FAZW0001.The structural elucidation and configurational reassessments of compounds 1−5 were established through comprehensive spectral analyses,with their absolute configurations determined via single crystal X-ray diffraction using Cu Kαradiation,Marfey’s method,and comparison between experimental and calculated electronic circular dichroism(ECD)spectra.Compounds 1,2,and 8 exhibited significant anti-inflammatory activities in Propionibacterium acnes(P.acnes)-induced human monocyte cell lines.Compound 8 demonstrated the ability to down-regulate interleukin-1β(IL-1β)expression by inhibiting Toll-like receptor 2(TLR2)expression and modulating the activation of myeloid differentiation factor 88(MyD88),mitogen-activated protein kinase(MAPK),and nuclear factorκB(NF-κB)signaling pathways,thus reducing the cellular inflammatory response induced by P.acnes.Additionally,compound 8 showed the capacity to suppress mitochondrial reactive oxygen species(ROS)production and nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation,thereby reducing IL-1βmaturation and secretion.A three-dimensional quantitative structure-activity relationships(3D-QSAR)model was applied to compounds 5−12 to analyze their anti-inflammatory structure-activity relationships.展开更多
基金National Natural Science Foundation of China(52175237)。
文摘The key parameters that characterize the morphological quality of multi-layer and multi-pass metal laser deposited parts are the surface roughness and the error between the actual printing height and the theoretical model height.The Taguchi method was employed to establish the correlations between process parameter combinations and multi-objective characterization of metal deposition morphology(height error and roughness).Results show that using the signal-to-noise ratio and grey relational analysis,the optimal parameter combination for multi-layer and multi-pass deposition is determined as follows:laser power of 800 W,powder feeding rate of 0.3 r/min,step distance of 1.6 mm,and scanning speed of 20 mm/s.Subsequently,a Genetic Bayesian-back propagation(GB-BP)network is constructed to predict multi-objective responses.Compared with the traditional back propagation network,the GB-back propagation network improves the prediction accuracy of height error and surface roughness by 43.14%and 71.43%,respectively.This network can accurately predict the multi-objective characterization of morphological quality of multi-layer and multi-pass metal deposited parts.
文摘In this study,polyacrylic acid(PAA)films were employed as a model system,and a series of PAA films with tunable water wettability was systematically prepared by varying molecular weight and curing temperature.Using attenuated total reflectance Fourier-transform infrared spectroscopy(ATR-FTIR),the molecular configurations of surface carboxyl groups(COOH),free carboxyl(COOH_(f))and hydrogen-bonded carboxyl(COOH_(HB),were directly correlated with the polar component of surface energy(γ^(s,p)).By decomposing theγ^(s,p)values of the PAA thin films as a sum of the contributions of COOH_(f)and COOH_(H B),the intrinsic polar component of surface energy of COOH_(H B)(γ_(H B)^(s,p*))was quantified for the first time as 8.34 mN/m,significantly lower than that of COOH_(f)(γ_(f)^(s,p*)=34 mN/m).This result highlights that hydrogen bonding markedly reduces theγ^(s,p),providing a rational explanation for the relatively large water contact angle observed on PAA thin films.Furthermore,it establishes a thermodynamic basis for estimating the fraction of surface COOH_(H B)groups(f H B)from wettability measurements.Further extension of the model to carboxyl-terminated self-assembled monolayers(COOH-SAMs)revealed that surface COOH density(ΣCOOH)critically regulates wetting behavior:whenΣCOOH ranges from 4.30 to 5.25 nm^(-2),COOH groups predominantly exist in a free state and facilitate effective hydration layers,thereby promoting superhydrophilicity.Overall,this study not only establishes a unified thermodynamic framework linking surface COOH configurations to macroscopic wettability,but also validates its universality by extending it to COOH-SAMs systems,thereby providing a unified theoretical framework for the controllable design of hydrophilicity in various COOH-functionalized surfaces.
基金supported by the National Natural Science Foundation of China (Nos.82293682,82293684,and 82173703)。
文摘Owing to their intricate molecular frameworks and copious chiral centers,the structural identification and configurational assignment of natural products are challenging tasks.Comprehensive spectral data analysis is crucial for the confirmation of absolute configurations.Ignoring critical parameters will lead to false structure,which may confuse the total synthesis and drug development.Herein,the configurations of seven heterogeneous Pallavicinia diterpenoids(PDs) isolated from Pallavicinia liverworts are revised using a combination of single-crystal X-ray diffraction and electronic circular dichroism(ECD) calculations.Meanwhile,identification of five unprecedented PD heterodimers PD-dimers A-E(18-22) along with eleven previously undescribed PDs(5-9,13-17,23) obtained by the reinvestigation of the Chinese liverwort Pallavicinia subciliata have resulted in corrections and support the revised conclusions.
基金supported by the National Natural Science Foundation of China(22265021,52231007,and 12327804)the Aeronautical Science Foundation of China(2020Z056056003)Jiangxi Provincial Natural Science Foundation(20232BAB212004).
文摘The precise tuning of magnetic nanoparticle size and magnetic domains,thereby shaping magnetic properties.However,the dynamic evolution mechanisms of magnetic domain configurations in relation to electromagnetic(EM)attenuation behavior remain poorly understood.To address this gap,a thermodynamically controlled periodic coordination strategy is proposed to achieve precise modulation of magnetic nanoparticle spacing.This approach unveils the evolution of magnetic domain configurations,progressing from individual to coupled and ultimately to crosslinked domain configurations.A unique magnetic coupling phenomenon surpasses the Snoek limit in low-frequency range,which is observed through micromagnetic simulation.The crosslinked magnetic configuration achieves effective low-frequency EM wave absorption at 3.68 GHz,encompassing nearly the entire C-band.This exceptional magnetic interaction significantly enhances radar camouflage and thermal insulation properties.Additionally,a robust gradient metamaterial design extends coverage across the full band(2–40 GHz),effectively mitigating the impact of EM pollution on human health and environment.This comprehensive study elucidates the evolution mechanisms of magnetic domain configurations,addresses gaps in dynamic magnetic modulation,and provides novel insights for the development of high-performance,low-frequency EM wave absorption materials.
基金supported by the National Key Research and Development Program of China(No.2022YFB3404700)the National Natural Science Foundation of China(Nos.52105313 and 52275299)+2 种基金the Research and Development Program of Beijing Municipal Education Commission,China(No.KM202210005036)the Natural Science Foundation of Chongqing,China(No.CSTB2023NSCQ-MSX0701)the National Defense Basic Research Projects of China(No.JCKY2022405C002).
文摘At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass components.In this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool head.The material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum alloys.The results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center area.Repeated friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped zone.The tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition sample.It is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping area.The multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.
基金funded by the National Natural Science Foundation of China(52167013)the Key Program of Natural Science Foundation of Gansu Province(24JRRA225)Natural Science Foundation of Gansu Province(23JRRA891).
文摘In the context of the“dual carbon”goals,to address issues such as high energy consumption,high costs,and low power quality in the rapid development of electrified railways,this study focused on the China Railways High-Speed 5 Electric Multiple Unit and proposed a mathematical model and capacity optimization method for an onboard energy storage system using lithium batteries and supercapacitors as storage media.Firstly,considering the electrical characteristics,weight,and volume of the storage media,a mathematical model of the energy storage system was established.Secondly,to tackle problems related to energy consumption and power quality,an energy management strategy was proposed that comprehensively considers peak shaving and valley filling and power quality by controlling the charge/discharge thresholds of the storage system.Thecapacity optimization adopted a bilevel programming model,with the series/parallel number of storage modules as variables,considering constraints imposed by the Direct Current to Direct Current converter,train load,and space.An improved Particle Swarm Optimization algorithm and linear programming solver were used to solve specific cases.The results show that the proposed onboard energy storage system can effectively achieve energy savings,reduce consumption,and improve power qualitywhile meeting the load and space limitations of the train.
基金supported by the Biological Breeding-National Science and Technology Major Project(2023ZD0403305)National Natural Science Foundation of China(32101845)+1 种基金the National Key Research and Development Program of China(2023YFE0105000)the China Agriculture Research System(CARS-04).
文摘Dense cropping increases crop yield but intensifies resource competition,which reduces single plant yield and limits potential yield growth.Optimizing canopy spacing could enhance resource utilization,support crop morphological development and increase yield.Here,a three-year study was performed to verify the feasibility of adjusting row spacing to further enhance yield in densely planted soybeans.Of three row-spacing configurations(40-40,20-40,and 20-60 cm)and two planting densities(normal 180,000 plants ha 1 and high 270,000 plants ha 1).The differences in canopy structure,plant morphological development,photosynthetic capacity and their impact on yield were analyzed.Row spacing configurations have a significant effect on canopy transmittance(CT).The 20-60 cm row spacing configuration increased CT and creates a favorable canopy light environment,in which plant height is reduced,while branching is promoted.This approach reduces plant competition,optimizes the developments of leaf area per plant,specific leaf area,leaf area development rate,leaf area duration and photosynthetic physiological indices(F_(v)/F_(m),ETR,P_(n)).The significant increase of 11.9%-34.2%in canopy apparent photosynthesis(CAP)is attributed to the significant optimization of plant growth and photosynthetic physiology through CT,an important contributing factor to yield increases.The yield in the 20-60 cm treatment is 4.0%higher than in equidistant planting under normal planting density,but 5.9%under high density,primarily driven by CAP and pod number.These findings suggest that suitable row spacing configurations optimize the light environment for plants,promote source-sink transformation in soybeans,and further improve yield.In practice,a 20-60 cm row spacing configuration could be employed for high-density soybean planting to achieve a more substantial yield gain.
基金the National Natural Science Foundation of China(Nos.42076220,42206234,42476228)the Laoshan Laboratory Science and Technology Innovation Project(Nos.LSKJ202203404,LSKJ202203401)+2 种基金the Laoshan Laboratory‘14th FiveYear Plan’Major Project(No.2021QNLM020001-1)the Project of China Geological Survey(Nos.DD20230317,DD20230410,DD20190818,DD20191032,DD20160152)the Asia Cooperation Foundation‘China-Pakistan Oil and Gas Resource Potential Assessment and Capacity Training’。
文摘Recent advances in earth science and exploration have made deepwater channel-levee systems a research focus.We collected and analyzed over 10000 km of two-dimensional multichannel seismic data from the offshore Indus Basin to identify channellevee systems at various hierarchical levels depending on their seismic reflection characteristics.Seismic facies analysis was integrated with well data to map the spatial distribution of channel-levee systems in the offshore Indus Basin across various geological periods,and the factors influencing their development were discussed.These systems within the basin were identified using a developed,refined three-tier classification method.The first-order system consists of multiple spatially stacked complexes,the second-order system continuously developed multistage channel-levee bodies,and the third-order system represents the smallest identifiable sedimentary units on seismic profiles.Our findings demonstrate the evolution of the offshore Indus Basin from a single-stage channel with lateral migration to multistage vertical channel stacking from the Miocene to the Pleistocene.Tectonic activities exert their effect on channel-levee systems through their influence on the relative sea level.They also trigger volcanic or seismic events and affect siliciclastic supply.Warm and humid climate conditions form large river systems,which aid in the transport of terrestrial debris to the basin margin.Most channel-levee systems are assumed to have formed during low sea-level periods.This study offers new insights into the formation and evolution of turbidite sedimentary systems in the offshore Indus Basin and presents a practical classification method for comprehending gravity-flow sedimentary configurations and deepwater hydrocarbon exploration.
基金the support of the Key Research and Development Program of Shaanxi Province,China(No.2021GXLH-Z-049)。
文摘The influence of geometric configuration on the friction characteristics during incremental sheet forming of AA5052 was analyzed by integrating surface morphology and its characteristic parameters,along with plastic strain,contact pressure,and area.The interface promotes lubrication and support when wall angles were≤40°,a 0.5 mm-thin sheet was used,and a 10 mm-large tool radius was employed.This mainly results in micro-plowing and plastic extrusion flow,leading to lower friction coefficient.However,when wall angles exceed 40°,significant plastic strain roughening occurs,leading to inadequate lubrication on the newly formed surface.Increased sheet thickness and decreased tool radius elevate contact pressure.These actions trigger micro-cutting and adhesion,potentially leading to localized scuffing and dimple tears,and higher friction coefficient.The friction mechanisms remain unaffected by the part’s plane curve features.As the forming process progresses,abrasive wear intensifies,and surface morphology evolves unfavorably for lubrication and friction reduction.
基金supported by National Natural Science Foundation of China (NSFC) (Nos.62201217 and 51821005)。
文摘The field-reversed configuration(FRC)plasma thruster driven by rotating magnetic field(RMF),abbreviated as the RMF-FRC thruster,is a new type of electric propulsion technology that is expected to accelerate the deep space exploration.An experimental prototype,including diagnostic devices,was designed and constructed based on the principles of the RMF-FRC thruster,with an RMF frequency of 210 kHz and a maximum peak current of 2 kA.Under the rated operating conditions,the initial plasma density was measured to be 5×10^(17)m^(-3),and increased to 2.2×10^(19)m^(-3)after the action of RMF.The coupling efficiency of RMF was about 53%,and the plasma current reached 1.9 kA.The axial magnetic field changed in reverse by 155 Gauss,successfully reversing the bias magnetic field of 60 Gauss,which verifies the formation of FRC plasma.After optimization research,it was found that when the bias magnetic field is 100 Gauss,the axial magnetic field reverse variation caused by FRC is the highest at 164 Gauss.The experimental results are discussed and strategies are proposed to improve the performance of the prototype.
文摘Hydroxyapatite nanoparticles(HAP NPs)were synthesized by a one‐step hydrothermal method.The surface of HAP NPs was grafted-SH and-COOH chelating groups via in situ surface‐modification with iminodiacetic acid(IDA)and 3‐mercaptopropyl trimethoxysilane(MPS)to afford dual surface‐capped nano‐amendment HAPIDA/MPS.The structure of HAP‐IDA/MPS was characterized,and its adsorption performance for Hg^(2+),Cu^(2+),Zn^(2+),Ni^(2+),Co^(2+),and Cd^(2+)was evaluated.The total adsorption capacity of 0.10 g HAP‐IDA/MPS nano‐amendment for Hg^(2+),Cu^(2+),Zn^(2+),Ni^(2+),Co^(2+),and Cd^(2+)with an initial mass concentration of 20 mg·L^(-1) reached 13.7 mg·g^(-1),about 4.3 times as much as that of HAP.Notably,HAP‐IDA/MPS nano‐amendment displayed the highest immobilization rate for Hg^(2+),possibly because of its chemical reaction with-SH to form sulfide,possessing the lowest solubility product constant among a variety of metal sulfides.
基金co-supported by the National Natural Science Foundation of China(Nos.52272408,U21B2008)the Guangdong Basic and Applied Basic Research Foundation,China(No.2023B1515120018)。
文摘This paper investigates the configuration design associated with boundary-constrained swarm flying.An analytic swarm configuration is identified to ensure the passive safety between each pair of spacecraft in the radial-cross-track plane.For the first time,this work derives the explicit configurable spacecraft amount to clarify the configuration's accommodation capacity while considering the maximum inter-spacecraft separation constraint.For larger-scale design problem that involves hundreds of spacecraft,this paper proposes an optimization framework that integrates a Relative Orbit Element(ROE)affine transformation operation and successional convex optimization.The framework establishes a multi-subcluster swarm structure,allowing decoupling the maintenance issues of each subcluster.Compared with previous design methods,it ensures that the computational cost for constraints verification only scales linearly with the swarm size,while also preserving the configuration optimization capacities.Numerical simulations demonstrate that the proposed analytic configuration strictly meets the design constraints.It is also shown that the proposed framework reduces the handled constraint amount by two orders compared with direct optimization,while achieving a remarkable swarm safety enhancement based on the existing analytic configuration.
文摘With the continuous application of new technologies in reconnaissance and attack, false camouflage plays a more important role in improving the survivability of targets, and the number of decoys plays a crucial role in the camouflaging effect. Based on the concept of cost-effectiveness ratio, according to the newly formulated Johnson criterion and the view of discovery and destruction, this paper proposes to take the identification probability as the probability of being destroyed and uses mathematical formulas to calculate the cost of a single use decoy. On this basis, a cost-effectiveness ratio model is established, with the product of the increase in the survival probability of the target and the cost of the target as the benefit, and the sum of the product of the probability of being destroyed and the cost of the decoy and the cost of a single use as the consumption cost. The model is calculated and analyzed, and the number of decoys that conform to the actual situation is obtained.
基金supported in part by the National Key Laboratory of Science and Technology on Space Microwave(Grant Nos.HTKJ2022KL504009 and HTKJ2022KL5040010).
文摘With the increase in the quantity and scale of Static Random-Access Memory Field Programmable Gate Arrays (SRAM-based FPGAs) for aerospace application, the volume of FPGA configuration bit files that must be stored has increased dramatically. The use of compression techniques for these bitstream files is emerging as a key strategy to alleviate the burden on storage resources. Due to the severe resource constraints of space-based electronics and the unique application environment, the simplicity, efficiency and robustness of the decompression circuitry is also a key design consideration. Through comparative analysis current bitstream file compression technologies, this research suggests that the Lempel Ziv Oberhumer (LZO) compression algorithm is more suitable for satellite applications. This paper also delves into the compression process and format of the LZO compression algorithm, as well as the inherent characteristics of configuration bitstream files. We propose an improved algorithm based on LZO for bitstream file compression, which optimises the compression process by refining the format and reducing the offset. Furthermore, a low-cost, robust decompression hardware architecture is proposed based on this method. Experimental results show that the compression speed of the improved LZO algorithm is increased by 3%, the decompression hardware cost is reduced by approximately 60%, and the compression ratio is slightly reduced by 0.47%.
文摘Through on-site investigations and case analyses of green mines in Huizhou City,and by integrating technical measures including soil improvement,plant configuration,and community construction,this study proposes a plant configuration model tailored for ecological restoration in the mining areas of Huizhou.The implementation of a multi-level configuration model that predominantly employs native plant species,combined with a"soil-vegetation-microorganism"collaborative restoration strategy,can significantly enhance vegetation coverage in mining areas,increase soil organic matter content,and reduce the bioavailability of heavy metals in the soil.Based on field research and case study analyses,several optimization recommendations are proposed from the perspectives of slope stability and soil and water conservation.Ultimately,it summarizes plant configuration models and their application effects in the ecological restoration of green mines in Huizhou City.These findings may serve as valuable references for the ecological restoration of mines in South China.
基金Supported by the National Natural Science Foundation of China(Grant No.52172409)Postdoctoral Innovation Talents Support Program(Grant No.BX20240298)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.2682024GF023)Heilongjiang Province Postdoctoral Foundation Project(Grant No.LBH-Z23041).
文摘The huge impact kinetic energy cannot be quickly dissipated by the energy-absorbing structure and transferred to the other vehicle through the car body structure,which will cause structural damage and threaten the lives of the occupants.Therefore,it is necessary to understand the laws of energy conversion,dissipation and transfer during train collisions.This study proposes a multi-layer progressive analysis method of energy flow during train collisions,considering the characteristics of the train.In this method,the train collision system is divided into conversion,dissipation,and transfer layers from the perspective of the train,collision interface,and car body structure to analyze the energy conversion,dissipation and transfer characteristics.Taking the collision process of a rail train as an example,a train collision energy transfer path analysis model was established based on power flow theory.The results show that when the maximum mean acceleration of the vehicle meets the standard requirements,the jerk may exceed the allowable limit of the human body,and there is a risk of injury to the occupants of a secondary collision.The decay rate of the collision energy along the direction of train operation reaches 79%.As the collision progresses,the collision energy gradually converges in the structure with holes,and the structure deforms when the gathered energy is greater than the maximum energy the structure can withstand.The proposed method helps to understand the train collision energy flow law and provides theoretical support for the train crashworthiness design in the future.
基金National Natural Science Foundation of China under Grant No. 52378483the Fundamental Research Funds for the Central Universities under Grant No. DUT21JC07+1 种基金the Scientific Research Fund of Institute of Engineering MechanicsChina Earthquake Administration under Grant No. 2021D17
文摘A substation is a complex coupled system composed of various electrical equipment.Compared with standalone equipment,there is a significant coupling effect in the seismic response of interconnected equipment.To address this issue,this study investigates the seismic interaction of substation equipment with multiple electrical configurations and proposes an improved seismic design method.First,the concept of the coupling coefficient is introduced,which is used to improve the Newmark-βmethod and response spectrum method for the seismic design of standalone equipment.Then,the finite element models of a substation system with multiple configurations are established,and the vibration characteristics and seismic responses of the interconnected equipment are investigated.Finally,the coupling coefficients are obtained by kernel density estimation of the response results under twenty seismic ground motions,and the effectiveness of the proposed method is verified through two numerical examples.The results show that the frequency coupling coefficients vary from 0.69 to 1.42,while the seismic action coupling coefficient has a wider range,changing from 1.04 to 3.91.The coupling effect amplifies the seismic response of higher-frequency equipment,and the amplification degree varies among different configurations for the same type of equipment.
基金Nourah bint Abdulrahman University for funding this project through the Researchers Supporting Project(PNURSP2025R319)Riyadh,Saudi Arabia and Prince Sultan University for covering the article processing charges(APC)associated with this publication.Special acknowledgement to Automated Systems&Soft Computing Lab(ASSCL),Prince Sultan University,Riyadh,Saudi Arabia.
文摘The growing incidence of cyberattacks necessitates a robust and effective Intrusion Detection Systems(IDS)for enhanced network security.While conventional IDSs can be unsuitable for detecting different and emerging attacks,there is a demand for better techniques to improve detection reliability.This study introduces a new method,the Deep Adaptive Multi-Layer Attention Network(DAMLAN),to boost the result of intrusion detection on network data.Due to its multi-scale attention mechanisms and graph features,DAMLAN aims to address both known and unknown intrusions.The real-world NSL-KDD dataset,a popular choice among IDS researchers,is used to assess the proposed model.There are 67,343 normal samples and 58,630 intrusion attacks in the training set,12,833 normal samples,and 9711 intrusion attacks in the test set.Thus,the proposed DAMLAN method is more effective than the standard models due to the consideration of patterns by the attention layers.The experimental performance of the proposed model demonstrates that it achieves 99.26%training accuracy and 90.68%testing accuracy,with precision reaching 98.54%on the training set and 96.64%on the testing set.The recall and F1 scores again support the model with training set values of 99.90%and 99.21%and testing set values of 86.65%and 91.37%.These results provide a strong basis for the claims made regarding the model’s potential to identify intrusion attacks and affirm its relatively strong overall performance,irrespective of type.Future work would employ more attempts to extend the scalability and applicability of DAMLAN for real-time use in intrusion detection systems.
基金supported by the National Natural Science Foun-dation of China(Grant Nos.52073128 and 11964012)the Foundation of Educational Committee of Jiangxi Province of China(Grant No.GJJ2201314).
文摘Solution environment can influence the flexible structure of DNA under specific conditions,thereby affecting the stability of nucleic acids and ultimately impacting critical biological processes such as replication and transcription.Intracellular solution environment is variable,and previous studies have demonstrated that it can enhance the stability of DNA structures under certain circumstances.In this work,molecular dynamics simulations were conducted on B-DNA(1ZEW,with a nucleotide sequence of CCTCTAGAGG)derived from human breast cancer cells(MDA-MB231)to explore the effects of ethanol solution on DNA configuration transformation at different temperatures and concentrations.The calculated results indicate that ethanol facilitates the transition of 1ZEW from B-DNA to A-DNA at lower temperature.Furthermore,it is observed that temperature affects DNA structure to some extent,thereby modifying the trend in DNA configuration transformation.At low temperatures,the ethanol can promote the transformation of B-DNA into A-DNA at higher concentrations.While at higher temperatures,the DNA could be in a state of thermal melting.These conclusions presented here can give valuable insights into how ethanol affects B-DNA configuration transformations.
基金supported by the National Natural Science Foundation of China(Nos.41876189 and 81703388)the State Key Laboratory of Bioreactor Engineering and Shanghai Collaborative Innovation Center for Biomanufacturing Technology.
文摘Two novel diketopiperazines(1 and 5),along with ten known compounds(2−4,6−12)demonstrating significant skin inflammation inhibition,were isolated from a marine-derived fungus identified as Aspergillus sp.FAZW0001.The structural elucidation and configurational reassessments of compounds 1−5 were established through comprehensive spectral analyses,with their absolute configurations determined via single crystal X-ray diffraction using Cu Kαradiation,Marfey’s method,and comparison between experimental and calculated electronic circular dichroism(ECD)spectra.Compounds 1,2,and 8 exhibited significant anti-inflammatory activities in Propionibacterium acnes(P.acnes)-induced human monocyte cell lines.Compound 8 demonstrated the ability to down-regulate interleukin-1β(IL-1β)expression by inhibiting Toll-like receptor 2(TLR2)expression and modulating the activation of myeloid differentiation factor 88(MyD88),mitogen-activated protein kinase(MAPK),and nuclear factorκB(NF-κB)signaling pathways,thus reducing the cellular inflammatory response induced by P.acnes.Additionally,compound 8 showed the capacity to suppress mitochondrial reactive oxygen species(ROS)production and nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation,thereby reducing IL-1βmaturation and secretion.A three-dimensional quantitative structure-activity relationships(3D-QSAR)model was applied to compounds 5−12 to analyze their anti-inflammatory structure-activity relationships.
