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Multi-Label Machine Learning Classification of Cardiovascular Diseases
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作者 Chih-Ta Yen Jung-Ren Wong Chia-Hsang Chang 《Computers, Materials & Continua》 2025年第7期347-363,共17页
In its 2023 global health statistics,the World Health Organization noted that noncommunicable diseases(NCDs)remain the leading cause of disease burden worldwide,with cardiovascular diseases(CVDs)resulting in more deat... In its 2023 global health statistics,the World Health Organization noted that noncommunicable diseases(NCDs)remain the leading cause of disease burden worldwide,with cardiovascular diseases(CVDs)resulting in more deaths than the three other major NCDs combined.In this study,we developed a method that can comprehensively detect which CVDs are present in a patient.Specifically,we propose a multi-label classification method that utilizes photoplethysmography(PPG)signals and physiological characteristics from public datasets to classify four types of CVDs and related conditions:hypertension,diabetes,cerebral infarction,and cerebrovascular disease.Our approach to multi-disease classification of cardiovascular diseases(CVDs)using PPG signals achieves the highest classification performance when encompassing the broadest range of disease categories,thereby offering a more comprehensive assessment of human health.We employ a multi-label classification strategy to simultaneously predict the presence or absence of multiple diseases.Specifically,we first apply the Savitzky-Golay(S-G)filter to the PPG signals to reduce noise and then transform into statistical features.We integrate processed PPG signals with individual physiological features as a multimodal input,thereby expanding the learned feature space.Notably,even with a simple machine learning method,this approach can achieve relatively high accuracy.The proposed method achieved a maximum F1-score of 0.91,minimum Hamming loss of 0.04,and an accuracy of 0.95.Thus,our method represents an effective and rapid solution for detecting multiple diseases simultaneously,which is beneficial for comprehensively managing CVDs. 展开更多
关键词 PHOTOPLETHYSMOGRAPHY machine learning health management multi-label classification cardiovascu-lar disease
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Denoising graph neural network based on zero-shot learning for Gibbs phenomenon in high-order DG applications
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作者 Wei AN Jiawen LIU +3 位作者 Wenxuan OUYANG Haoyu RU Xuejun LIU Hongqiang LYU 《Chinese Journal of Aeronautics》 2025年第3期234-248,共15页
With the availability of high-performance computing technology and the development of advanced numerical simulation methods, Computational Fluid Dynamics (CFD) is becoming more and more practical and efficient in engi... With the availability of high-performance computing technology and the development of advanced numerical simulation methods, Computational Fluid Dynamics (CFD) is becoming more and more practical and efficient in engineering. As one of the high-precision representative algorithms, the high-order Discontinuous Galerkin Method (DGM) has not only attracted widespread attention from scholars in the CFD research community, but also received strong development. However, when DGM is extended to high-speed aerodynamic flow field calculations, non-physical numerical Gibbs oscillations near shock waves often significantly affect the numerical accuracy and even cause calculation failure. Data driven approaches based on machine learning techniques can be used to learn the characteristics of Gibbs noise, which motivates us to use it in high-speed DG applications. To achieve this goal, labeled data need to be generated in order to train the machine learning models. This paper proposes a new method for denoising modeling of Gibbs phenomenon using a machine learning technique, the zero-shot learning strategy, to eliminate acquiring large amounts of CFD data. The model adopts a graph convolutional network combined with graph attention mechanism to learn the denoising paradigm from synthetic Gibbs noise data and generalize to DGM numerical simulation data. Numerical simulation results show that the Gibbs denoising model proposed in this paper can suppress the numerical oscillation near shock waves in the high-order DGM. Our work automates the extension of DGM to high-speed aerodynamic flow field calculations with higher generalization and lower cost. 展开更多
关键词 Computational fluid dynamics High-order discon tinuous Galerkin method Gibbs phenomenon Graph neural networks zero-shot learning
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基于反向投影的zero-shot learning目标分类算法研究 被引量:1
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作者 冯鹏 庹红娅 +2 位作者 乔凌峰 王洁欣 敬忠良 《计算机应用研究》 CSCD 北大核心 2017年第11期3291-3294,共4页
Zero-shot learning(ZSL)是针对没有训练样本的类别进行分类的问题。传统回归方法的核心是将视觉特征投影到语义空间,没有充分利用视觉特征自身包含的样本信息,同时训练计算量大。提出基于反向投影的ZSL目标分类方法,将类别原型投影到... Zero-shot learning(ZSL)是针对没有训练样本的类别进行分类的问题。传统回归方法的核心是将视觉特征投影到语义空间,没有充分利用视觉特征自身包含的样本信息,同时训练计算量大。提出基于反向投影的ZSL目标分类方法,将类别原型投影到视觉空间,利用视觉特征的语义性学习出映射函数,参数优化过程仅通过解析解就可以获得。在两个基准数据集的实验结果表明,提出的反向投影方法分类结果较传统回归方法和其他现有方法有大幅提升,并且训练时间大大减少,可以更好地推广到未知类别的分类问题上。 展开更多
关键词 zero-shot learning 目标分类 反向投影 解析解
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Zero-shot Fine-grained Classification by Deep Feature Learning with Semantics 被引量:8
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作者 Ao-Xue Li Ke-Xin Zhang Li-Wei Wang 《International Journal of Automation and computing》 EI CSCD 2019年第5期563-574,共12页
Fine-grained image classification, which aims to distinguish images with subtle distinctions, is a challenging task for two main reasons: lack of sufficient training data for every class and difficulty in learning dis... Fine-grained image classification, which aims to distinguish images with subtle distinctions, is a challenging task for two main reasons: lack of sufficient training data for every class and difficulty in learning discriminative features for representation. In this paper, to address the two issues, we propose a two-phase framework for recognizing images from unseen fine-grained classes, i.e., zeroshot fine-grained classification. In the first feature learning phase, we finetune deep convolutional neural networks using hierarchical semantic structure among fine-grained classes to extract discriminative deep visual features. Meanwhile, a domain adaptation structure is induced into deep convolutional neural networks to avoid domain shift from training data to test data. In the second label inference phase, a semantic directed graph is constructed over attributes of fine-grained classes. Based on this graph, we develop a label propagation algorithm to infer the labels of images in the unseen classes. Experimental results on two benchmark datasets demonstrate that our model outperforms the state-of-the-art zero-shot learning models. In addition, the features obtained by our feature learning model also yield significant gains when they are used by other zero-shot learning models, which shows the flexility of our model in zero-shot finegrained classification. 展开更多
关键词 FINE-GRAINED image CLASSIFICATION zero-shot learning DEEP FEATURE learning domain adaptation semantic graph
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Multi-label learning algorithm with SVM based association 被引量:4
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作者 Feng Pan Qin Danyang +3 位作者 Ji Ping Ma Jingya Zhang Yan Yang Songxiang 《High Technology Letters》 EI CAS 2019年第1期97-104,共8页
Multi-label learning is an active research area which plays an important role in machine learning. Traditional learning algorithms, however, have to depend on samples with complete labels. The existing learning algori... Multi-label learning is an active research area which plays an important role in machine learning. Traditional learning algorithms, however, have to depend on samples with complete labels. The existing learning algorithms with missing labels do not consider the relevance of labels, resulting in label estimation errors of new samples. A new multi-label learning algorithm with support vector machine(SVM) based association(SVMA) is proposed to estimate missing labels by constructing the association between different labels. SVMA will establish a mapping function to minimize the number of samples in the margin while ensuring the margin large enough as well as minimizing the misclassification probability. To evaluate the performance of SVMA in the condition of missing labels, four typical data sets are adopted with the integrity of the labels being handled manually. Simulation results show the superiority of SVMA in dealing with the samples with missing labels compared with other models in image classification. 展开更多
关键词 multi-label learning missing labels ASSOCIATION support vector machine(SVM)
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Multi-Label Learning Based on Transfer Learning and Label Correlation 被引量:2
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作者 Kehua Yang Chaowei She +2 位作者 Wei Zhang Jiqing Yao Shaosong Long 《Computers, Materials & Continua》 SCIE EI 2019年第7期155-169,共15页
In recent years,multi-label learning has received a lot of attention.However,most of the existing methods only consider global label correlation or local label correlation.In fact,on the one hand,both global and local... In recent years,multi-label learning has received a lot of attention.However,most of the existing methods only consider global label correlation or local label correlation.In fact,on the one hand,both global and local label correlations can appear in real-world situation at same time.On the other hand,we should not be limited to pairwise labels while ignoring the high-order label correlation.In this paper,we propose a novel and effective method called GLLCBN for multi-label learning.Firstly,we obtain the global label correlation by exploiting label semantic similarity.Then,we analyze the pairwise labels in the label space of the data set to acquire the local correlation.Next,we build the original version of the label dependency model by global and local label correlations.After that,we use graph theory,probability theory and Bayesian networks to eliminate redundant dependency structure in the initial version model,so as to get the optimal label dependent model.Finally,we obtain the feature extraction model by adjusting the Inception V3 model of convolution neural network and combine it with the GLLCBN model to achieve the multi-label learning.The experimental results show that our proposed model has better performance than other multi-label learning methods in performance evaluating. 展开更多
关键词 Bayesian networks multi-label learning global and local label correlations transfer learning
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Stable Label-Specific Features Generation for Multi-Label Learning via Mixture-Based Clustering Ensemble 被引量:1
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作者 Yi-Bo Wang Jun-Yi Hang Min-Ling Zhang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2022年第7期1248-1261,共14页
Multi-label learning deals with objects associated with multiple class labels,and aims to induce a predictive model which can assign a set of relevant class labels for an unseen instance.Since each class might possess... Multi-label learning deals with objects associated with multiple class labels,and aims to induce a predictive model which can assign a set of relevant class labels for an unseen instance.Since each class might possess its own characteristics,the strategy of extracting label-specific features has been widely employed to improve the discrimination process in multi-label learning,where the predictive model is induced based on tailored features specific to each class label instead of the identical instance representations.As a representative approach,LIFT generates label-specific features by conducting clustering analysis.However,its performance may be degraded due to the inherent instability of the single clustering algorithm.To improve this,a novel multi-label learning approach named SENCE(stable label-Specific features gENeration for multi-label learning via mixture-based Clustering Ensemble)is proposed,which stabilizes the generation process of label-specific features via clustering ensemble techniques.Specifically,more stable clustering results are obtained by firstly augmenting the original instance repre-sentation with cluster assignments from base clusters and then fitting a mixture model via the expectation-maximization(EM)algorithm.Extensive experiments on eighteen benchmark data sets show that SENCE performs better than LIFT and other well-established multi-label learning algorithms. 展开更多
关键词 Clustering ensemble expectation-maximization al-gorithm label-specific features multi-label learning
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iATC_Deep-mISF: A Multi-Label Classifier for Predicting the Classes of Anatomical Therapeutic Chemicals by Deep Learning 被引量:1
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作者 Zhe Lu Kuo-Chen Chou 《Advances in Bioscience and Biotechnology》 2020年第5期153-159,共7页
The recent worldwide spreading of pneumonia-causing virus, such as Coronavirus, COVID-19, and H1N1, has been endangering the life of human beings all around the world. To provide useful clues for developing antiviral ... The recent worldwide spreading of pneumonia-causing virus, such as Coronavirus, COVID-19, and H1N1, has been endangering the life of human beings all around the world. To provide useful clues for developing antiviral drugs, information of anatomical therapeutic chemicals is vitally important. In view of this, a CNN based predictor called “iATC_Deep-mISF” has been developed. The predictor is particularly useful in dealing with the multi-label systems in which some chemicals may occur in two or more different classes. To maximize the convenience for most experimental scientists, a user-friendly web-server for the new predictor has been established at http://www.jci-bioinfo.cn/iATC_Deep-mISF/, which will become a very powerful tool for developing effective drugs to fight pandemic coronavirus and save the mankind of this planet. 展开更多
关键词 PANDEMIC CORONAVIRUS multi-label System ANATOMICAL THERAPEUTIC CHEMICALS learning at Deeper Level Five-Steps Rule
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ML-ANet:A Transfer Learning Approach Using Adaptation Network for Multi-label Image Classification in Autonomous Driving
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作者 Guofa Li Zefeng Ji +3 位作者 Yunlong Chang Shen Li Xingda Qu Dongpu Cao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2021年第5期107-117,共11页
To reduce the discrepancy between the source and target domains,a new multi-label adaptation network(ML-ANet)based on multiple kernel variants with maximum mean discrepancies is proposed in this paper.The hidden repre... To reduce the discrepancy between the source and target domains,a new multi-label adaptation network(ML-ANet)based on multiple kernel variants with maximum mean discrepancies is proposed in this paper.The hidden representations of the task-specific layers in ML-ANet are embedded in the reproducing kernel Hilbert space(RKHS)so that the mean-embeddings of specific features in different domains could be precisely matched.Multiple kernel functions are used to improve feature distribution efficiency for explicit mean embedding matching,which can further reduce domain discrepancy.Adverse weather and cross-camera adaptation examinations are conducted to verify the effectiveness of our proposed ML-ANet.The results show that our proposed ML-ANet achieves higher accuracies than the compared state-of-the-art methods for multi-label image classification in both the adverse weather adaptation and cross-camera adaptation experiments.These results indicate that ML-ANet can alleviate the reliance on fully labeled training data and improve the accuracy of multi-label image classification in various domain shift scenarios. 展开更多
关键词 Autonomous vehicles Deep learning Image classification multi-label learning Transfer learning
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Learning Label Correlations for Multi-Label Online Passive Aggressive Classification Algorithm
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作者 ZHANG Yongwei 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2024年第1期51-58,共8页
Label correlations are an essential technique for data mining that solves the possible correlation problem between different labels in multi-label classification.Although this technique is widely used in multi-label c... Label correlations are an essential technique for data mining that solves the possible correlation problem between different labels in multi-label classification.Although this technique is widely used in multi-label classification problems,batch learning deals with most issues,which consumes a lot of time and space resources.Unlike traditional batch learning methods,online learning represents a promising family of efficient and scalable machine learning algorithms for large-scale datasets.However,existing online learning research has done little to consider correlations between labels.On the basis of existing research,this paper proposes a multi-label online learning algorithm based on label correlations by maximizing the interval between related labels and unrelated labels in multi-label samples.We evaluate the performance of the proposed algorithm on several public datasets.Experiments show the effectiveness of our algorithm. 展开更多
关键词 label correlations passive aggressive multi-label classification online learning
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A Novel Framework for Learning and Classifying the Imbalanced Multi-Label Data
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作者 P.K.A.Chitra S.Appavu alias Balamurugan +3 位作者 S.Geetha Seifedine Kadry Jungeun Kim Keejun Han 《Computer Systems Science & Engineering》 2024年第5期1367-1385,共19页
A generalization of supervised single-label learning based on the assumption that each sample in a dataset may belong to more than one class simultaneously is called multi-label learning.The main objective of this wor... A generalization of supervised single-label learning based on the assumption that each sample in a dataset may belong to more than one class simultaneously is called multi-label learning.The main objective of this work is to create a novel framework for learning and classifying imbalancedmulti-label data.This work proposes a framework of two phases.The imbalanced distribution of themulti-label dataset is addressed through the proposed Borderline MLSMOTE resampling method in phase 1.Later,an adaptive weighted l21 norm regularized(Elastic-net)multilabel logistic regression is used to predict unseen samples in phase 2.The proposed Borderline MLSMOTE resampling method focuses on samples with concurrent high labels in contrast to conventional MLSMOTE.The minority labels in these samples are called difficult minority labels and are more prone to penalize classification performance.The concurrentmeasure is considered borderline,and labels associated with samples are regarded as borderline labels in the decision boundary.In phase II,a novel adaptive l21 norm regularized weighted multi-label logistic regression is used to handle balanced data with different weighted synthetic samples.Experimentation on various benchmark datasets shows the outperformance of the proposed method and its powerful predictive performances over existing conventional state-of-the-art multi-label methods. 展开更多
关键词 multi-label imbalanced data multi-label learning Borderline MLSMOTE concurrent multi-label adaptive weighted multi-label elastic net difficult minority label
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Boosting Adaptive Weighted Broad Learning System for Multi-Label Learning
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作者 Yuanxin Lin Zhiwen Yu +2 位作者 Kaixiang Yang Ziwei Fan C.L.Philip Chen 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第11期2204-2219,共16页
Multi-label classification is a challenging problem that has attracted significant attention from researchers, particularly in the domain of image and text attribute annotation. However, multi-label datasets are prone... Multi-label classification is a challenging problem that has attracted significant attention from researchers, particularly in the domain of image and text attribute annotation. However, multi-label datasets are prone to serious intra-class and inter-class imbalance problems, which can significantly degrade the classification performance. To address the above issues, we propose the multi-label weighted broad learning system(MLW-BLS) from the perspective of label imbalance weighting and label correlation mining. Further, we propose the multi-label adaptive weighted broad learning system(MLAW-BLS) to adaptively adjust the specific weights and values of labels of MLW-BLS and construct an efficient imbalanced classifier set. Extensive experiments are conducted on various datasets to evaluate the effectiveness of the proposed model, and the results demonstrate its superiority over other advanced approaches. 展开更多
关键词 Broad learning system label correlation mining label imbalance weighting multi-label imbalance
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A Dual Discriminator Method for Generalized Zero-Shot Learning
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作者 Tianshu Wei Jinjie Huang 《Computers, Materials & Continua》 SCIE EI 2024年第4期1599-1612,共14页
Zero-shot learning enables the recognition of new class samples by migrating models learned from semanticfeatures and existing sample features to things that have never been seen before. The problems of consistencyof ... Zero-shot learning enables the recognition of new class samples by migrating models learned from semanticfeatures and existing sample features to things that have never been seen before. The problems of consistencyof different types of features and domain shift problems are two of the critical issues in zero-shot learning. Toaddress both of these issues, this paper proposes a new modeling structure. The traditional approach mappedsemantic features and visual features into the same feature space;based on this, a dual discriminator approachis used in the proposed model. This dual discriminator approach can further enhance the consistency betweensemantic and visual features. At the same time, this approach can also align unseen class semantic features andtraining set samples, providing a portion of information about the unseen classes. In addition, a new feature fusionmethod is proposed in the model. This method is equivalent to adding perturbation to the seen class features,which can reduce the degree to which the classification results in the model are biased towards the seen classes.At the same time, this feature fusion method can provide part of the information of the unseen classes, improvingits classification accuracy in generalized zero-shot learning and reducing domain bias. The proposed method isvalidated and compared with othermethods on four datasets, and fromthe experimental results, it can be seen thatthe method proposed in this paper achieves promising results. 展开更多
关键词 Generalized zero-shot learning modality consistent DISCRIMINATOR domain shift problem feature fusion
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Multi-label learning of face demographic classification for correlation analysis
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作者 方昱春 程功 罗婕 《Journal of Shanghai University(English Edition)》 CAS 2011年第5期352-356,共5页
In this paper, we utilize the framework of multi-label learning for face demographic classification. We also attempt t;o explore the suitable classifiers and features for face demographic classification. Three most po... In this paper, we utilize the framework of multi-label learning for face demographic classification. We also attempt t;o explore the suitable classifiers and features for face demographic classification. Three most popular demographic information, gender, ethnicity and age are considered in experiments. Based on the results from demographic classification, we utilize statistic analysis to explore the correlation among various face demographic information. Through the analysis, we draw several conclusions on the correlation and interaction among these high-level face semantic, and the obtained results can be helpful in automatic face semantic annotation and other face analysis tasks. 展开更多
关键词 denlographic classification multi-label learning face analysis
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Inverse design of nonlinear phononic crystal configurations based on multi-label classification learning neural networks
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作者 Kunqi Huang Yiran Lin +1 位作者 Yun Lai Xiaozhou Liu 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第10期295-301,共7页
Phononic crystals,as artificial composite materials,have sparked significant interest due to their novel characteristics that emerge upon the introduction of nonlinearity.Among these properties,second-harmonic feature... Phononic crystals,as artificial composite materials,have sparked significant interest due to their novel characteristics that emerge upon the introduction of nonlinearity.Among these properties,second-harmonic features exhibit potential applications in acoustic frequency conversion,non-reciprocal wave propagation,and non-destructive testing.Precisely manipulating the harmonic band structure presents a major challenge in the design of nonlinear phononic crystals.Traditional design approaches based on parameter adjustments to meet specific application requirements are inefficient and often yield suboptimal performance.Therefore,this paper develops a design methodology using Softmax logistic regression and multi-label classification learning to inversely design the material distribution of nonlinear phononic crystals by exploiting information from harmonic transmission spectra.The results demonstrate that the neural network-based inverse design method can effectively tailor nonlinear phononic crystals with desired functionalities.This work establishes a mapping relationship between the band structure and the material distribution within phononic crystals,providing valuable insights into the inverse design of metamaterials. 展开更多
关键词 multi-label classification learning nonlinear phononic crystals inverse design
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Optimization Model and Algorithm for Multi-Label Learning
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作者 Zhengyang Li 《Journal of Applied Mathematics and Physics》 2021年第5期969-975,共7页
<div style="text-align:justify;"> This paper studies a kind of urban security risk assessment model based on multi-label learning, which is transformed into the solution of linear equations through a s... <div style="text-align:justify;"> This paper studies a kind of urban security risk assessment model based on multi-label learning, which is transformed into the solution of linear equations through a series of transformations, and then the solution of linear equations is transformed into an optimization problem. Finally, this paper uses some classical optimization algorithms to solve these optimization problems, the convergence of the algorithm is proved, and the advantages and disadvantages of several optimization methods are compared. </div> 展开更多
关键词 Operations Research multi-label learning Linear Equations Solving Optimization Algorithm
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Explanatory Multi-Scale Adversarial Semantic Embedding Space Learning for Zero-Shot Recognition
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作者 Huiting Li 《Open Journal of Applied Sciences》 2022年第3期317-335,共19页
The goal of zero-shot recognition is to classify classes it has never seen before, which needs to build a bridge between seen and unseen classes through semantic embedding space. Therefore, semantic embedding space le... The goal of zero-shot recognition is to classify classes it has never seen before, which needs to build a bridge between seen and unseen classes through semantic embedding space. Therefore, semantic embedding space learning plays an important role in zero-shot recognition. Among existing works, semantic embedding space is mainly taken by user-defined attribute vectors. However, the discriminative information included in the user-defined attribute vector is limited. In this paper, we propose to learn an extra latent attribute space automatically to produce a more generalized and discriminative semantic embedded space. To prevent the bias problem, both user-defined attribute vector and latent attribute space are optimized by adversarial learning with auto-encoders. We also propose to reconstruct semantic patterns produced by explanatory graphs, which can make semantic embedding space more sensitive to usefully semantic information and less sensitive to useless information. The proposed method is evaluated on the AwA2 and CUB dataset. These results show that our proposed method achieves superior performance. 展开更多
关键词 zero-shot Recognition Semantic Embedding Space Adversarial learning Explanatory Graph
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Learning Multi Labels from Single Label——An Extreme Weak Label Learning Algorithm 被引量:1
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作者 DUAN Junhong LI Xiaoyu MU Dejun 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2019年第2期161-168,共8页
This paper presents a novel algorithm for an extreme form of weak label learning, in which only one of all relevant labels is given for each training sample. Using genetic algorithm, all of the labels in the training ... This paper presents a novel algorithm for an extreme form of weak label learning, in which only one of all relevant labels is given for each training sample. Using genetic algorithm, all of the labels in the training set are optimally divided into several non-overlapping groups to maximize the label distinguishability in every group. Multiple classifiers are trained separately and ensembled for label predictions. Experimental results show significant improvement over previous weak label learning algorithms. 展开更多
关键词 weak-supervised learning genetic algorithm multi-label classification
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pLoc_Deep-mHum: Predict Subcellular Localization of Human Proteins by Deep Learning 被引量:3
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作者 Yu-Tao Shao Xin-Xin Liu +1 位作者 Zhe Lu Kuo-Chen Chou 《Natural Science》 2020年第7期526-551,共26页
Recently, the life of human beings around the entire world has been endangering by the spreading of pneumonia-causing virus, such as Coronavirus, COVID-19, and H1N1. To develop effective drugs against Coronavirus, kno... Recently, the life of human beings around the entire world has been endangering by the spreading of pneumonia-causing virus, such as Coronavirus, COVID-19, and H1N1. To develop effective drugs against Coronavirus, knowledge of protein subcellular localization is indispensable. In 2019, a predictor called “pLoc_bal-mHum” was developed for identifying the subcellular localization of human proteins. Its predicted results are significantly better than its counterparts, particularly for those proteins that may simultaneously occur or move between two or more subcellular location sites. However, more efforts are definitely needed to further improve its power since pLoc_bal-mHum was still not trained by a “deep learning”, a very powerful technique developed recently. The present study was devoted to incorporate the “deep-learning” technique and develop a new predictor called “pLoc_Deep-mHum”. The global absolute true rate achieved by the new predictor is over 81% and its local accuracy is over 90%. Both are overwhelmingly superior to its counterparts. Moreover, a user-friendly web-server for the new predictor has been well established at http://www.jci-bioinfo.cn/pLoc_Deep-mHum/, which will become a very useful tool for fighting pandemic coronavirus and save the mankind of this planet. 展开更多
关键词 CORONAVIRUS multi-label System Human Proteins Deep learning Five-Steps Rule PseAAC
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pLoc_Deep-mVirus: A CNN Model for Predicting Subcellular Localization of Virus Proteins by Deep Learning 被引量:3
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作者 Yutao Shao Kuo-Chen Chou 《Natural Science》 2020年第6期388-399,共12页
<p class="MsoNormal"> <span lang="EN-US" style="" color:black;"="">The recent worldwide spreading of pneumonia-causing virus, such as Coronavirus, </span>... <p class="MsoNormal"> <span lang="EN-US" style="" color:black;"="">The recent worldwide spreading of pneumonia-causing virus, such as Coronavirus, </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">COVID-19, and H1N1, has been endangering the life of human beings all around the world. In order to really understand the biological process within a cell level and provide useful clues to develop antiviral drugs, information of virus protein subcellular localization is vitally important. In view of this, a CNN based virus protein subcellular localization predictor called “pLoc_Deep-mVirus” was developed. The predictor is particularly useful in dealing with the multi-sites systems in which some proteins may simultaneously occur in two or more different organelles that are the current focus of pharmaceutical industry. The global absolute true rate achieved by the new predictor is over 97% and its local accuracy is over 98%. Both are transcending other existing state-of-the-art predictors significantly. It has not escaped our notice that the deep-learning treatment can be used to deal with many other biological systems as well. To maximize the convenience for most experimental scientists, a user-friendly web-server for the new predictor has been established at <a href="http://www.jci-bioinfo.cn/pLoc_Deep-mVirus/">http://www.jci-bioinfo.cn/pLoc_Deep-mVirus/</a>.</span> </p> 展开更多
关键词 CORONAVIRUS Virus Proteins multi-label System Deep learning Five-Steps Rule PseAAC
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