BACKGROUND Neoadjuvant therapy(NAT)for pancreatic cancer(PC)is becoming standardized,with neoadjuvant chemoradiotherapy(NACRT)showing proven effectiveness.However,the optimal endoscopic biliary drainage approach durin...BACKGROUND Neoadjuvant therapy(NAT)for pancreatic cancer(PC)is becoming standardized,with neoadjuvant chemoradiotherapy(NACRT)showing proven effectiveness.However,the optimal endoscopic biliary drainage approach during NAT remains controversial.In this single-center retrospective case series,we report the use of a novel multi-hole self-expandable metallic stent(MH-SEMS)for preoperative biliary drainage during NACRT in patients with PC.AIM To assess the feasibility of endoscopic biliary drainage using MH-SEMS during NACRT in patients with malignant distal biliary obstruction secondary to resectable and borderline resectable PC.METHODS We included 14 patients—10 with resectable,2 with borderline resectable,and 2 with unresectable locally advanced disease—who had undergone surgery after biliary drainage using MH-SEMS(diameter:10 mm).Clinical and technical success was achieved in all patients,with a median interval of 105 days between stent placement and surgery.RESULTS A partial response was observed in five patients(35.7%),whereas nine patients(64.3%)exhibited stable disease.Only one patient(7.1%)developed moderate cholangitis from recurrent biliary obstruction caused by sludge 337 days after stent placement during systemic chemotherapy,requiring MH-SEMS replacement.Pathological examination of postoperative specimens revealed tumor shrinkage in many cases,and no stent migration was observed.Adverse events included mild pancreatitis in two patients(14.3%)and moderate pancreatitis in one patient(7.1%),as defined by the Tokyo Criteria 2024.CONCLUSION No cases of cholecystitis,liver abscess,or hemorrhage were reported.No disadvantages in surgical procedures or postoperative complications related to MH-SEMS placement were observed.展开更多
A series of computations is conducted for many multi-hole arrangements at several blowing ratios to further investigate the evolution of the film from multi-holes. The influence of multi-hole arrangement on effusion f...A series of computations is conducted for many multi-hole arrangements at several blowing ratios to further investigate the evolution of the film from multi-holes. The influence of multi-hole arrangement on effusion film cooling is analyzed and a preliminary relationship evaluating the film development from developing state to developed state is brought forward. Results show that the coolant jets from front rows of multi-holes merge rapidly and the strength of the kidney vortices due to mainstream-coolant jet interaction in the downstream region are mitigated under super-long-diamond arrangement where the streamwise hole-to-hole pitch is bigger than spanwise hole-to-hole pitch. The holes array arranged in super-long-diamond mode is not only in favor of obtaining developed film layer, but also improving averaged adiabatic film cooling effectiveness.展开更多
This study firstly defines a set of arrangement rule for perforated holes of multi-hole orifice(MO), and then presents three critical geometrical parameters including total number of performated hole, equivalent diame...This study firstly defines a set of arrangement rule for perforated holes of multi-hole orifice(MO), and then presents three critical geometrical parameters including total number of performated hole, equivalent diameter ratio and distribution density of perforated holes, which are to quantify MO structure. This paper built the throttling test apparatus for nice test MO plates, which were designed according to orthogonal theory. The experiments were conducted to investigate the effect of three critical geometerical parameters on the pressure loss coefficient of test MOs. Results show that equivalent diameter ratio is the dominant prameter affecting MO throttling characterstic.展开更多
In order to analyze the influence of the hole chamfer on the metering performances of a Multi-hole Orifice Flowmeter and optimize the related orifice structure,a multi-hole orifice flowmeter with DN80 and throttle rat...In order to analyze the influence of the hole chamfer on the metering performances of a Multi-hole Orifice Flowmeter and optimize the related orifice structure,a multi-hole orifice flowmeter with DN80 and throttle ratio of 0.45 was considered in the present study.The flow field characteristics were determined in the framework of a CFD technique.The results show that the multi-hole orifice flowmeter with filleting transition around the throttle orifice has higher accuracy in a wide range of the space of parameters,and is more suitable for accurate measurement of fluid in process control.展开更多
Conventional surface seismic exploration in areas with complex surfaces such as karst landforms has been faced with the problem of poor excitation and reception conditions.RVSP(reverse vertical seismic profile)seismic...Conventional surface seismic exploration in areas with complex surfaces such as karst landforms has been faced with the problem of poor excitation and reception conditions.RVSP(reverse vertical seismic profile)seismic exploration adopts a geometry in which the sources are downhole and receivers are on the ground which can reduce the influence of complex surfaces on seismic wave propagation(to some extent).Through numerical simulations and real data analysis,it was noted that in areas with complex surfaces and large numbers of underground karst caves,seismic waves generated in shallow boreholes are easily affected by various surface and multiple waves as well as by scattering from karst bodies.Therefore,the quality of the reflected seismic data is extremely low.Also,it is difficult to improve the signal to noise ratio(SNR)with conventional noise filtering methods.However,when the source depth is increased,the quality of the reflected waves can be improved.This is exactly what the RVSP method accomplishes.Besides,for the RVSP method,due to its particular geometry,the apparent velocities of the reflected waves and most interference waves are quite different,which can help to filter most noise to further improve the SNR of the reflected signals.In this study,a 3 D-RVSP exploration study using 8-hole joint acquisition was conducted in a typical karst landform.The results show that the 3 D-RVSP method can obtain higher quality seismic data for complex surface conditions that have large numbers of underground karst caves.Furthermore,multi-hole joint acquisition for 3 D-RVSP has higher data collection efficiency and better uniformity of underground coverage.Therefore,in this study,38 faults were accurately revealed and at high resolution based on the 3 D-RVSP imaging results.展开更多
Based on the elementary solutions and new integral equations,a new analytical-numerical method is proposed to calculate the interacting stresses of multiple circular holes in an infinite elastic plate under both remot...Based on the elementary solutions and new integral equations,a new analytical-numerical method is proposed to calculate the interacting stresses of multiple circular holes in an infinite elastic plate under both remote stresses and arbitrarily distributed stresses applied to the circular boundaries.The validity of this new analytical-numerical method is verified by the analytical solution of the bi-harmonic stress function method,the numerical solution of the finite element method,and the analytical-numerical solutions of the series expansion and Laurent series methods.Some numerical examples are presented to investigate the effects of the hole geometry parameters(radii and relative positions)and loading conditions(remote stresses and surface stresses)on the interacting tangential stresses and interacting stress concentration factors(SCFs).The results show that whether the interference effect is shielding(k<1)or amplifying(k>1)depends on the relative orientation of holes(α)and remote stresses(σ^∞x,σ^∞y).When the maximum principal stress is aligned with the connecting line of two-hole centers andσ^∞y<0.5σ^∞x,the plate containing two circular holes has greater stability than that containing one circular hole,and the smaller circular hole has greater stability than the bigger one.This new method not only has a simple formulation and high accuracy,but also has an advantage of wide applications over common analytical methods and analytical-numerical methods in calculating the interacting stresses of a multi-hole problem under both remote and arbitrary surface stresses.展开更多
A throttling experiment for the multi-hole orifice （MO） using water was conducted based on the conclusion of key parameters affecting the MO throttling performance. Testing MOs and standard orifice plates （ SO ） w...A throttling experiment for the multi-hole orifice （MO） using water was conducted based on the conclusion of key parameters affecting the MO throttling performance. Testing MOs and standard orifice plates （ SO ） were designed for the throttling experiment to compare the throttling effect using the equivalent diameter ratio （RED） and diameter ratio （RD ） as key parameters, respectively. Meanwhile, effective metrical conditions were provided for experimental accuracy. The throttling model form was determined according to the theoretical throttling model of SO. Then the unknown parameters involved were identified by experimental data. A good concordance between the modeling computation and experimental results shows a validation of the MO throtting model.展开更多
A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of...A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of an oxidation- confined 850 nm VCSEL. The single-mode output power of 2.6 mW, threshold current of 0.6 mA, full width of half maximum lasing spectrum of less than 0.1 nm, side mode suppression ratio of 28.4 dB, and far-field divergence angle of about 10% are obtained. The effects of different hole depths on the optical characteristics are simulated and analysed, including far-field divergence, spectrum and lateral cavity mode. The single-mode performance of this multi-hole device is attributed to the large radiation loss from the inter hole spacing and the scattering loss at the bottom of the holes, particularly for higher order modes.展开更多
BACKGROUND Uncovered stents used for malignant obstructions in the biliary tree, especially in the hilar area, are prone to obstruction by tumor ingrowths. In comparison, however, covered stents may block bile duct br...BACKGROUND Uncovered stents used for malignant obstructions in the biliary tree, especially in the hilar area, are prone to obstruction by tumor ingrowths. In comparison, however, covered stents may block bile duct branches and are at risk of migration. We have developed a multi-hole self-expandable metallic stent (MHSEMS), with a hole in each cell, to prevent the obstruction of bile duct branches. In addition, the holes may prevent migration due to small ingrowths by reducing the tension of the membrane. CASE SUMMARY MHSEMS were placed in five patients with a malignant obstruction and one with post-endoscopic sphincterotomy bleeding. Each MHSEMS was successfully deployed in all cases. Patients showed no complications. Two cases were reviewed. Case 1: A 74-year-old male presented with jaundice and was diagnosed with a sigmoid colon cancer and giant liver metastases in the right liver lobe. A MHSEMS was placed in the left bile duct. The jaundice improved and peroral cholangioscopy was performed. Case 2: A 90-year-old female was admitted to hospital for jaundice and diagnosed with cholangiocarcinoma. A MHSEMS was placed in the left bile duct but after 8 months the stent became obstructed by tumor ingrowth. We treated the patient by ablation therapy. A silicone cover separated the internal bile duct from the surrounding tissue, protecting the latter from thermal injury during treatment by endobiliary ablation of the reobstruction. CONCLUSION A MHSEMS is a new choice of stent for biliary tract diseases.展开更多
In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distanc...In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still unclear.Besides,wetting front migration distance and leaching time are usually required to optimize the leaching process.In this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head height.At the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were identical.At the postintersection stage,the intersection accelerated the wetting front migration.By using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the intersection.Finally,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was established.Error analysis results showed that the proposed model can accurately simulate the infiltration process under experimental conditions.The research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future.展开更多
Combining real accelerating genetic algorithm(RAGA) with the optimization design of multi-hole and varied diameter pipe, the authors solved the problem of optimizing multi-dimensional parameters at the same time. In w...Combining real accelerating genetic algorithm(RAGA) with the optimization design of multi-hole and varied diameter pipe, the authors solved the problem of optimizing multi-dimensional parameters at the same time. In which the advanced convergence and easily to run into partial optimization were avoid. Applied the RAGA to solving the problem in the optimization design of fixed piping sprinkler irrigation system. The optimized parameters, such as diameters and the length of pipe were calculated and the result was reasonable, which provides as a reference to readers who work at related research.展开更多
Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crac...Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.展开更多
The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmiss...The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.展开更多
Liver cancer is the fourth cause of cancer-related deaths and the primary cause of death in patients with compensated cirrhosis.In recent years,the role of traditional Chinese medicine in the treatment of liver cancer...Liver cancer is the fourth cause of cancer-related deaths and the primary cause of death in patients with compensated cirrhosis.In recent years,the role of traditional Chinese medicine in the treatment of liver cancer has attracted more and more attention and recognition.Luteolin(LUT)and glycyrrhetinic(GA)are natural compounds extracted from Chinese herbal medicine.LUT exhibits various biological activity including anti-inflammatory,antibacterial,antiviral,anti-tumor,and neuroprotective effects.GA significantly inhibits the growth and metastasis of cancer cells.However,the low water solubility of both compounds hinders their clinical applications.In this study,rod-shaped nanoparticles(NPs)self-assembled from LUT and GA were designed to enhance drug solubility and tumor-targeting capability.We verified that the assembly mechanism of the NPs was π-π stacking.These NPs significantly inhibited the proliferation of liver cancer cells while had no significant effect on normal liver cells.In a mouse model of liver cancer,these NPs demonstrated superior tumor-targeting ability due to the enhanced permeability and retention effect,and the affinity of GA for liver cancer cells,resulting in better therapeutic efficacy with lower systemic toxicity.Results of network pharmacology analysis showed that LUT and GA respectively targeted estrogen receptor 1(ESR1)protein and cyclin-dependent kinase 1(CDK1)protein to corporately induce tumor cell cycle arrest,which induced the inhibition of tumor cell proliferation.In conclusion,this study provides a novel reference for the treatment of liver cancer.展开更多
The flexoelectric effect refers to the electromechanical coupling between electric polarization and mechanical strain gradient.It universally exists in a variety of materials in any space group,such as liquid crystals...The flexoelectric effect refers to the electromechanical coupling between electric polarization and mechanical strain gradient.It universally exists in a variety of materials in any space group,such as liquid crystals,dielectrics,biological materials,and semiconductors.Because of its unique size effect,nanoscale flexoelectricity has shown novel phenomena and promising applications in electronics,optronics,mechatronics,and photovoltaics.In this review,we provide a succinct report on the discovery and development of the flexoelectric effect,focusing on flexoelectric materials and related applications.Finally,we discuss recent flexoelectric research progress and still‐unsolved problems.展开更多
The paper presents a multi-holes shell with one hundred and eighty circular holes which has been used in engineering. Using a buckling module of the finite element analysis software, stability behavior and destroy mod...The paper presents a multi-holes shell with one hundred and eighty circular holes which has been used in engineering. Using a buckling module of the finite element analysis software, stability behavior and destroy mode along geometry parameters are studied. Results show the destroy mode depends on the geometry parameter greatly. Curves of buckling critical load and strength limited load along geometry parameters have a point of intersection. The point implies the multi-holes shell has different destroy mode and the value of point is change in geometry parameters.展开更多
This study explores the housing distribution effect of the Housing Provident Fund(HPF)system on households.Utilizing data from the China Household Finance Survey conducted in 2013,2015,2017,and 2019,this study empiric...This study explores the housing distribution effect of the Housing Provident Fund(HPF)system on households.Utilizing data from the China Household Finance Survey conducted in 2013,2015,2017,and 2019,this study empirically investigates this effect from two dimensions:the impact of HPF payments on household income and housing loan behavior,and the impact on the Gini coefficient of housing assets within the group.The results indicate that the HPF payment does not significantly impact household income levels.Instead,it increases their likelihood of obtaining housing loans,particularly for middle-income households.Additionally,for any group of families,the HPF payment decreased the housing Gini coefficient among households by approximately 0.11 units.This study may be the first to provide the most direct empirical evidence on the extent of HPF’s impact on housing inequality within a group.It also questions the inference in the literature that“HPF will aggravate housing inequality within the group.”Based on this study’s findings,we expect that housing inequality will continue to be alleviated with continued HPF implementation.In particular,this effect will be more significant if the credit support for lowincome families to purchase houses through the HPF can be further enhanced.展开更多
Agricultural intensification has led to an increase in monoculture and the use of chemical pesticides,resulting in a decline in biodiversity and a reduction in ecosystem services,particularly biological pest managemen...Agricultural intensification has led to an increase in monoculture and the use of chemical pesticides,resulting in a decline in biodiversity and a reduction in ecosystem services,particularly biological pest management.However,studies have shown that agroforestry can not only improve land productivity and biodiversity but also regulate some ecosystem services.This study reviews the impacts of physical and biological factors on herbivorous pests,parasites,and predatory natural enemies in fruit-crop agroforestry systems.Fruit-crop agroforestry systems provide high spatial heterogeneity by altering crop layouts,regulating the microclimate and soil quality,and offering food resources and shelter for natural enemies,thus promoting biological pest control.This enhances biological control and makes the agrocomplex system an effective tool for sustainable agriculture.Our research shows that volatile plant substances attract or repel pests and natural enemies based on the characteristics of the insects themselves.When scientifically designed,fruit-crop agroforestry systems provide high spatial heterogeneity and favorable microclimatic conditions,which enhance biological pest control and make the agroforestry system an effective tool for sustainable agriculture.Our research shows that fruit-crop agroforestry systems can provide richer food resources and habitat,enhancing biological pest control and improving pest management.展开更多
Fertilization or atmospheric deposition of nitrogen(N)and phosphorus(P)to terrestrial ecosystems can alter soil N(P)availability and the nature of nutrient limitation for plant growth.Changing the allocation of leaf P...Fertilization or atmospheric deposition of nitrogen(N)and phosphorus(P)to terrestrial ecosystems can alter soil N(P)availability and the nature of nutrient limitation for plant growth.Changing the allocation of leaf P fractions is potentially an adaptive strategy for plants to cope with soil N(P)availability and nutrient-limiting conditions.However,the impact of the interactions between imbalanced anthropogenic N and P inputs on the concentrations and allocation proportions of leaf P fractions in forest woody plants remains elusive.We conducted a metaanalysis of data about the concentrations and allocation proportions of leaf P fractions,specifically associated with individual and combined additions of N and P in evergreen forests,the dominant vegetation type in southern China where the primary productivity is usually considered limited by P.This assessment allowed us to quantitatively evaluate the effects of N and P additions alone and interactively on leaf P allocation and use strategies.Nitrogen addition(exacerbating P limitation)reduced the concentrations of leaf total P and different leaf P fractions.Nitrogen addition reduced the allocation to leaf metabolic P but increased the allocation to other fractions,while P addition showed opposite trends.The simultaneous additions of N and P showed an antagonistic(mutual suppression)effect on the concentrations of leaf P fractions,but an additive(summary)effect on the allocation proportions of leaf P fractions.These results highlight the importance of strategies of leaf P fraction allocation in forest plants under changes in environmental nutrient availability.Importantly,our study identified critical interactions associated with combined N and P inputs that affect leaf P fractions,thus aiding in predicting plant acclimation strategies in the context of intensifying and imbalanced anthropogenic nutrient inputs.展开更多
With the rapid development of artificial intelligence,magnetocaloric materials as well as other materials are being developed with increased efficiency and enhanced performance.However,most studies do not take phase t...With the rapid development of artificial intelligence,magnetocaloric materials as well as other materials are being developed with increased efficiency and enhanced performance.However,most studies do not take phase transitions into account,and as a result,the predictions are usually not accurate enough.In this context,we have established an explicable relationship between alloy compositions and phase transition by feature imputation.A facile machine learning is proposed to screen candidate NiMn-based Heusler alloys with desired magnetic entropy change and magnetic transition temperature with a high accuracy R^(2)≈0.98.As expected,the measured properties of prepared NiMn-based alloys,including phase transition type,magnetic entropy changes and transition temperature,are all in good agreement with the ML predictions.As well as being the first to demonstrate an explicable relationship between alloy compositions,phase transitions and magnetocaloric properties,our proposed ML model is highly predictive and interpretable,which can provide a strong theoretical foundation for identifying high-performance magnetocaloric materials in the future.展开更多
文摘BACKGROUND Neoadjuvant therapy(NAT)for pancreatic cancer(PC)is becoming standardized,with neoadjuvant chemoradiotherapy(NACRT)showing proven effectiveness.However,the optimal endoscopic biliary drainage approach during NAT remains controversial.In this single-center retrospective case series,we report the use of a novel multi-hole self-expandable metallic stent(MH-SEMS)for preoperative biliary drainage during NACRT in patients with PC.AIM To assess the feasibility of endoscopic biliary drainage using MH-SEMS during NACRT in patients with malignant distal biliary obstruction secondary to resectable and borderline resectable PC.METHODS We included 14 patients—10 with resectable,2 with borderline resectable,and 2 with unresectable locally advanced disease—who had undergone surgery after biliary drainage using MH-SEMS(diameter:10 mm).Clinical and technical success was achieved in all patients,with a median interval of 105 days between stent placement and surgery.RESULTS A partial response was observed in five patients(35.7%),whereas nine patients(64.3%)exhibited stable disease.Only one patient(7.1%)developed moderate cholangitis from recurrent biliary obstruction caused by sludge 337 days after stent placement during systemic chemotherapy,requiring MH-SEMS replacement.Pathological examination of postoperative specimens revealed tumor shrinkage in many cases,and no stent migration was observed.Adverse events included mild pancreatitis in two patients(14.3%)and moderate pancreatitis in one patient(7.1%),as defined by the Tokyo Criteria 2024.CONCLUSION No cases of cholecystitis,liver abscess,or hemorrhage were reported.No disadvantages in surgical procedures or postoperative complications related to MH-SEMS placement were observed.
基金National Natural Science Foundation of China (50876041)
文摘A series of computations is conducted for many multi-hole arrangements at several blowing ratios to further investigate the evolution of the film from multi-holes. The influence of multi-hole arrangement on effusion film cooling is analyzed and a preliminary relationship evaluating the film development from developing state to developed state is brought forward. Results show that the coolant jets from front rows of multi-holes merge rapidly and the strength of the kidney vortices due to mainstream-coolant jet interaction in the downstream region are mitigated under super-long-diamond arrangement where the streamwise hole-to-hole pitch is bigger than spanwise hole-to-hole pitch. The holes array arranged in super-long-diamond mode is not only in favor of obtaining developed film layer, but also improving averaged adiabatic film cooling effectiveness.
基金Sponsored by National Natural Science Foundation of China (Grant No50578049)
文摘This study firstly defines a set of arrangement rule for perforated holes of multi-hole orifice(MO), and then presents three critical geometrical parameters including total number of performated hole, equivalent diameter ratio and distribution density of perforated holes, which are to quantify MO structure. This paper built the throttling test apparatus for nice test MO plates, which were designed according to orthogonal theory. The experiments were conducted to investigate the effect of three critical geometerical parameters on the pressure loss coefficient of test MOs. Results show that equivalent diameter ratio is the dominant prameter affecting MO throttling characterstic.
基金supports of Hebei province high-tech industry multiplier project(No.16211702D)Chengde science and technology&development project(No.20152013).
文摘In order to analyze the influence of the hole chamfer on the metering performances of a Multi-hole Orifice Flowmeter and optimize the related orifice structure,a multi-hole orifice flowmeter with DN80 and throttle ratio of 0.45 was considered in the present study.The flow field characteristics were determined in the framework of a CFD technique.The results show that the multi-hole orifice flowmeter with filleting transition around the throttle orifice has higher accuracy in a wide range of the space of parameters,and is more suitable for accurate measurement of fluid in process control.
基金funded jointly by National Key Research and Development Program of China(2017YFC0804105)Fundamental Research Funds for the Central Universities of China(2015XKMS036)+1 种基金Natural Science Foundation of Jiangsu Province(BK20160245)a Project Funded by Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Conventional surface seismic exploration in areas with complex surfaces such as karst landforms has been faced with the problem of poor excitation and reception conditions.RVSP(reverse vertical seismic profile)seismic exploration adopts a geometry in which the sources are downhole and receivers are on the ground which can reduce the influence of complex surfaces on seismic wave propagation(to some extent).Through numerical simulations and real data analysis,it was noted that in areas with complex surfaces and large numbers of underground karst caves,seismic waves generated in shallow boreholes are easily affected by various surface and multiple waves as well as by scattering from karst bodies.Therefore,the quality of the reflected seismic data is extremely low.Also,it is difficult to improve the signal to noise ratio(SNR)with conventional noise filtering methods.However,when the source depth is increased,the quality of the reflected waves can be improved.This is exactly what the RVSP method accomplishes.Besides,for the RVSP method,due to its particular geometry,the apparent velocities of the reflected waves and most interference waves are quite different,which can help to filter most noise to further improve the SNR of the reflected signals.In this study,a 3 D-RVSP exploration study using 8-hole joint acquisition was conducted in a typical karst landform.The results show that the 3 D-RVSP method can obtain higher quality seismic data for complex surface conditions that have large numbers of underground karst caves.Furthermore,multi-hole joint acquisition for 3 D-RVSP has higher data collection efficiency and better uniformity of underground coverage.Therefore,in this study,38 faults were accurately revealed and at high resolution based on the 3 D-RVSP imaging results.
基金Project supported by the National Natural Science Foundation of China(Nos.51474251,51874351,and 11502226)the Natural Science Foundation of Hunan Province of China(No.2019JJ50625)and the Key Research and Development Plan of Hunan Province of China(No.2017WK2032)。
文摘Based on the elementary solutions and new integral equations,a new analytical-numerical method is proposed to calculate the interacting stresses of multiple circular holes in an infinite elastic plate under both remote stresses and arbitrarily distributed stresses applied to the circular boundaries.The validity of this new analytical-numerical method is verified by the analytical solution of the bi-harmonic stress function method,the numerical solution of the finite element method,and the analytical-numerical solutions of the series expansion and Laurent series methods.Some numerical examples are presented to investigate the effects of the hole geometry parameters(radii and relative positions)and loading conditions(remote stresses and surface stresses)on the interacting tangential stresses and interacting stress concentration factors(SCFs).The results show that whether the interference effect is shielding(k<1)or amplifying(k>1)depends on the relative orientation of holes(α)and remote stresses(σ^∞x,σ^∞y).When the maximum principal stress is aligned with the connecting line of two-hole centers andσ^∞y<0.5σ^∞x,the plate containing two circular holes has greater stability than that containing one circular hole,and the smaller circular hole has greater stability than the bigger one.This new method not only has a simple formulation and high accuracy,but also has an advantage of wide applications over common analytical methods and analytical-numerical methods in calculating the interacting stresses of a multi-hole problem under both remote and arbitrary surface stresses.
基金the National Natural Science Foundation of China(Grant No.50578049)
文摘A throttling experiment for the multi-hole orifice （MO） using water was conducted based on the conclusion of key parameters affecting the MO throttling performance. Testing MOs and standard orifice plates （ SO ） were designed for the throttling experiment to compare the throttling effect using the equivalent diameter ratio （RED） and diameter ratio （RD ） as key parameters, respectively. Meanwhile, effective metrical conditions were provided for experimental accuracy. The throttling model form was determined according to the theoretical throttling model of SO. Then the unknown parameters involved were identified by experimental data. A good concordance between the modeling computation and experimental results shows a validation of the MO throtting model.
基金Project supported by the National High Technology Research and Development Program of China (Grant No. 2008AA03Z402)the National Natural Science Foundation of China (Grant No. 61076044)the Natural Science Foundation of Beijing,China(Grant Nos. 4092007 and 4102003)
文摘A multi-hole vertical-cavity surface-emitting laser （VCSEL） operating in stable single mode with a low threshold current was produced by introducing multi-leaf scallop holes on the top distributed Bragg-refleetor of an oxidation- confined 850 nm VCSEL. The single-mode output power of 2.6 mW, threshold current of 0.6 mA, full width of half maximum lasing spectrum of less than 0.1 nm, side mode suppression ratio of 28.4 dB, and far-field divergence angle of about 10% are obtained. The effects of different hole depths on the optical characteristics are simulated and analysed, including far-field divergence, spectrum and lateral cavity mode. The single-mode performance of this multi-hole device is attributed to the large radiation loss from the inter hole spacing and the scattering loss at the bottom of the holes, particularly for higher order modes.
文摘BACKGROUND Uncovered stents used for malignant obstructions in the biliary tree, especially in the hilar area, are prone to obstruction by tumor ingrowths. In comparison, however, covered stents may block bile duct branches and are at risk of migration. We have developed a multi-hole self-expandable metallic stent (MHSEMS), with a hole in each cell, to prevent the obstruction of bile duct branches. In addition, the holes may prevent migration due to small ingrowths by reducing the tension of the membrane. CASE SUMMARY MHSEMS were placed in five patients with a malignant obstruction and one with post-endoscopic sphincterotomy bleeding. Each MHSEMS was successfully deployed in all cases. Patients showed no complications. Two cases were reviewed. Case 1: A 74-year-old male presented with jaundice and was diagnosed with a sigmoid colon cancer and giant liver metastases in the right liver lobe. A MHSEMS was placed in the left bile duct. The jaundice improved and peroral cholangioscopy was performed. Case 2: A 90-year-old female was admitted to hospital for jaundice and diagnosed with cholangiocarcinoma. A MHSEMS was placed in the left bile duct but after 8 months the stent became obstructed by tumor ingrowth. We treated the patient by ablation therapy. A silicone cover separated the internal bile duct from the surrounding tissue, protecting the latter from thermal injury during treatment by endobiliary ablation of the reobstruction. CONCLUSION A MHSEMS is a new choice of stent for biliary tract diseases.
基金This research was funded by the National Natural Science Foundation of China(Grant No.52174113)the Young Jinggang Scholars Award Program in Jiangxi Province,China(Grant No.QNJG2018051)the“Thousand Talents”of Jiangxi Province,China(Grant No.jxsq2019201043).
文摘In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still unclear.Besides,wetting front migration distance and leaching time are usually required to optimize the leaching process.In this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head height.At the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were identical.At the postintersection stage,the intersection accelerated the wetting front migration.By using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the intersection.Finally,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was established.Error analysis results showed that the proposed model can accurately simulate the infiltration process under experimental conditions.The research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future.
文摘Combining real accelerating genetic algorithm(RAGA) with the optimization design of multi-hole and varied diameter pipe, the authors solved the problem of optimizing multi-dimensional parameters at the same time. In which the advanced convergence and easily to run into partial optimization were avoid. Applied the RAGA to solving the problem in the optimization design of fixed piping sprinkler irrigation system. The optimized parameters, such as diameters and the length of pipe were calculated and the result was reasonable, which provides as a reference to readers who work at related research.
基金funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan(Grant No.AP19680589).
文摘Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.
基金supported by the National Key R&D Program of China(No.2017YFB0304402)。
文摘The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.
基金the financial support from Henan Province Natural Science Foundation(No.252300420583)Henan Provincial Science and Technology Research Project(Nos.242102310455,242102310473,242102310517)the Key Project of Science and Technology Research funded by the Henan Provincial Department of Education(No.24A350002)。
文摘Liver cancer is the fourth cause of cancer-related deaths and the primary cause of death in patients with compensated cirrhosis.In recent years,the role of traditional Chinese medicine in the treatment of liver cancer has attracted more and more attention and recognition.Luteolin(LUT)and glycyrrhetinic(GA)are natural compounds extracted from Chinese herbal medicine.LUT exhibits various biological activity including anti-inflammatory,antibacterial,antiviral,anti-tumor,and neuroprotective effects.GA significantly inhibits the growth and metastasis of cancer cells.However,the low water solubility of both compounds hinders their clinical applications.In this study,rod-shaped nanoparticles(NPs)self-assembled from LUT and GA were designed to enhance drug solubility and tumor-targeting capability.We verified that the assembly mechanism of the NPs was π-π stacking.These NPs significantly inhibited the proliferation of liver cancer cells while had no significant effect on normal liver cells.In a mouse model of liver cancer,these NPs demonstrated superior tumor-targeting ability due to the enhanced permeability and retention effect,and the affinity of GA for liver cancer cells,resulting in better therapeutic efficacy with lower systemic toxicity.Results of network pharmacology analysis showed that LUT and GA respectively targeted estrogen receptor 1(ESR1)protein and cyclin-dependent kinase 1(CDK1)protein to corporately induce tumor cell cycle arrest,which induced the inhibition of tumor cell proliferation.In conclusion,this study provides a novel reference for the treatment of liver cancer.
基金support of the National Natural Science Foundation of China(Grant Nos.52192611,51872031,61904013,and 62405157)China Postdoctoral Science Foundation(Nos.2023M741890 and GZC20231215)the Fundamental Research Funds for the Central Universities.
文摘The flexoelectric effect refers to the electromechanical coupling between electric polarization and mechanical strain gradient.It universally exists in a variety of materials in any space group,such as liquid crystals,dielectrics,biological materials,and semiconductors.Because of its unique size effect,nanoscale flexoelectricity has shown novel phenomena and promising applications in electronics,optronics,mechatronics,and photovoltaics.In this review,we provide a succinct report on the discovery and development of the flexoelectric effect,focusing on flexoelectric materials and related applications.Finally,we discuss recent flexoelectric research progress and still‐unsolved problems.
基金supported by the Under graduate Thesis Foundation of Northwestern Polytechnic University
文摘The paper presents a multi-holes shell with one hundred and eighty circular holes which has been used in engineering. Using a buckling module of the finite element analysis software, stability behavior and destroy mode along geometry parameters are studied. Results show the destroy mode depends on the geometry parameter greatly. Curves of buckling critical load and strength limited load along geometry parameters have a point of intersection. The point implies the multi-holes shell has different destroy mode and the value of point is change in geometry parameters.
基金funded by the Humanities and Social Sciences Research Project of the Ministry of Education of China(Project No.23XJC790007).
文摘This study explores the housing distribution effect of the Housing Provident Fund(HPF)system on households.Utilizing data from the China Household Finance Survey conducted in 2013,2015,2017,and 2019,this study empirically investigates this effect from two dimensions:the impact of HPF payments on household income and housing loan behavior,and the impact on the Gini coefficient of housing assets within the group.The results indicate that the HPF payment does not significantly impact household income levels.Instead,it increases their likelihood of obtaining housing loans,particularly for middle-income households.Additionally,for any group of families,the HPF payment decreased the housing Gini coefficient among households by approximately 0.11 units.This study may be the first to provide the most direct empirical evidence on the extent of HPF’s impact on housing inequality within a group.It also questions the inference in the literature that“HPF will aggravate housing inequality within the group.”Based on this study’s findings,we expect that housing inequality will continue to be alleviated with continued HPF implementation.In particular,this effect will be more significant if the credit support for lowincome families to purchase houses through the HPF can be further enhanced.
文摘Agricultural intensification has led to an increase in monoculture and the use of chemical pesticides,resulting in a decline in biodiversity and a reduction in ecosystem services,particularly biological pest management.However,studies have shown that agroforestry can not only improve land productivity and biodiversity but also regulate some ecosystem services.This study reviews the impacts of physical and biological factors on herbivorous pests,parasites,and predatory natural enemies in fruit-crop agroforestry systems.Fruit-crop agroforestry systems provide high spatial heterogeneity by altering crop layouts,regulating the microclimate and soil quality,and offering food resources and shelter for natural enemies,thus promoting biological pest control.This enhances biological control and makes the agrocomplex system an effective tool for sustainable agriculture.Our research shows that volatile plant substances attract or repel pests and natural enemies based on the characteristics of the insects themselves.When scientifically designed,fruit-crop agroforestry systems provide high spatial heterogeneity and favorable microclimatic conditions,which enhance biological pest control and make the agroforestry system an effective tool for sustainable agriculture.Our research shows that fruit-crop agroforestry systems can provide richer food resources and habitat,enhancing biological pest control and improving pest management.
基金supported by the National Natural Science Foundation of China(No.41473068)supported by China Postdoctoral Science Foundation(No.2022M722667)。
文摘Fertilization or atmospheric deposition of nitrogen(N)and phosphorus(P)to terrestrial ecosystems can alter soil N(P)availability and the nature of nutrient limitation for plant growth.Changing the allocation of leaf P fractions is potentially an adaptive strategy for plants to cope with soil N(P)availability and nutrient-limiting conditions.However,the impact of the interactions between imbalanced anthropogenic N and P inputs on the concentrations and allocation proportions of leaf P fractions in forest woody plants remains elusive.We conducted a metaanalysis of data about the concentrations and allocation proportions of leaf P fractions,specifically associated with individual and combined additions of N and P in evergreen forests,the dominant vegetation type in southern China where the primary productivity is usually considered limited by P.This assessment allowed us to quantitatively evaluate the effects of N and P additions alone and interactively on leaf P allocation and use strategies.Nitrogen addition(exacerbating P limitation)reduced the concentrations of leaf total P and different leaf P fractions.Nitrogen addition reduced the allocation to leaf metabolic P but increased the allocation to other fractions,while P addition showed opposite trends.The simultaneous additions of N and P showed an antagonistic(mutual suppression)effect on the concentrations of leaf P fractions,but an additive(summary)effect on the allocation proportions of leaf P fractions.These results highlight the importance of strategies of leaf P fraction allocation in forest plants under changes in environmental nutrient availability.Importantly,our study identified critical interactions associated with combined N and P inputs that affect leaf P fractions,thus aiding in predicting plant acclimation strategies in the context of intensifying and imbalanced anthropogenic nutrient inputs.
基金supported by the National Key R&D Program of China(No.2022YFE0109500)the National Natural Science Foundation of China(Nos.52071255,52301250,52171190 and 12304027)+2 种基金the Key R&D Project of Shaanxi Province(No.2022GXLH-01-07)the Fundamental Research Funds for the Central Universities(China)the World-Class Universities(Disciplines)and the Characteristic Development Guidance Funds for the Central Universities.
文摘With the rapid development of artificial intelligence,magnetocaloric materials as well as other materials are being developed with increased efficiency and enhanced performance.However,most studies do not take phase transitions into account,and as a result,the predictions are usually not accurate enough.In this context,we have established an explicable relationship between alloy compositions and phase transition by feature imputation.A facile machine learning is proposed to screen candidate NiMn-based Heusler alloys with desired magnetic entropy change and magnetic transition temperature with a high accuracy R^(2)≈0.98.As expected,the measured properties of prepared NiMn-based alloys,including phase transition type,magnetic entropy changes and transition temperature,are all in good agreement with the ML predictions.As well as being the first to demonstrate an explicable relationship between alloy compositions,phase transitions and magnetocaloric properties,our proposed ML model is highly predictive and interpretable,which can provide a strong theoretical foundation for identifying high-performance magnetocaloric materials in the future.
