Sensor networks tend to support different traffic patterns since more and more emerging applications have diverse needs. We present MGRP, a Multi-Gradient Routing Protocol for wireless sensor networks, which is fully ...Sensor networks tend to support different traffic patterns since more and more emerging applications have diverse needs. We present MGRP, a Multi-Gradient Routing Protocol for wireless sensor networks, which is fully distributed and efficiently supports endto-end, one-to-many and many-to-one traffic patterns by effectively construct and maintain a gradient vector for each node. We further combine neighbor link estimation with routing information to reduce packet exchange on network dynamics and node failures. We have implemented MGRP on Tiny OS and evaluated its performance on real-world testbeds. The result shows MGRP achieves lower end-to-end packet delay in different traffic patterns compared to the state of the art routing protocols while still remains high packet delivery ratio.展开更多
Peripheral nerve defects present complex orthopedic challenges with limited efficacy of clinical interventions.The inadequate proliferation and dysfunction of Schwann cells within the nerve scaffold impede the effecti...Peripheral nerve defects present complex orthopedic challenges with limited efficacy of clinical interventions.The inadequate proliferation and dysfunction of Schwann cells within the nerve scaffold impede the effectiveness of nerve repair.Our previ-ous studies suggested the effectiveness of a magnesium-encapsulated bioactive hydrogel in repairing nerve defects.However,its rapid release of magnesium ions limited its efficacy to long-term nerve regeneration,and its molecular mechanism remains unclear.This study utilized electrospinning technology to fabricate a MgO/MgCO_(3)/polycaprolactone(PCL)multi-gradient nanofiber membrane for peripheral nerve regeneration.Our findings indicated that by carefully adjusting the concentration or proportion of rapidly degradable MgO and slowly degradable MgCO_(3),as well as the number of electrospun layers,the multi-gradient scaffold effectively sustained the release of Mg^(2+)over a period of 6 weeks.Additionally,this study provided insight into the mechanism of Mg^(2+)-induced nerve regeneration and confirmed that Mg^(2+)effectively promoted Schwann cell proliferation,migration,and transition to a repair phenotype.By employing transcriptome sequencing technology,the study identified the Wingless/integrase-1(Wnt)signaling pathway as a crucial mechanism influencing Schwann cell function during nerve regeneration.After implantation in 10 mm critically sized nerve defects in rats,the MgO/MgCO_(3)/PCL multi-gradient nanofiber combined with a 3D-engineered PCL nerve conduit showed enhanced axonal regeneration,remyelination,and reinnervation of muscle tissue 12 weeks post-surgery.In conclusion,this study successfully developed an innovative multi-gradient long-acting MgO/MgCO_(3)/PCL nanofiber with a tunable Mg^(2+)release property,which underscored the molecular mechanism of magnesium-encapsulated biomaterials in treating nervous system diseases and established a robust theoretical foundation for future clinical translation.展开更多
Multi-gradient drilling is a new offshore drilling method.The accurate calculation of the related wellbore temperature is of great significance for the prediction of the gas hydrate formation area and the precise cont...Multi-gradient drilling is a new offshore drilling method.The accurate calculation of the related wellbore temperature is of great significance for the prediction of the gas hydrate formation area and the precise control of the wellbore pressure.In this study,a new heat transfer model is proposed by which the variable mass flow is properly taken into account.Using this model,the effects of the main factors influencing the wellbore temperature are analyzed.The results indicate that at the position where the separation injection device is installed,the temperature increase of the fluid in the drill pipe is mitigated due to the inflow/outflow of hollow spheres,and the temperature drop of the fluid in the annulus also decreases.In addition,a lower separation efficiency of the device,a shallower installation depth and a smaller circulating displacement tend to increase the temperature near the bottom of the annulus,thereby helping to reduce the hydrate generation area and playing a positive role in the prevention and control of hydrates in deepwater drilling.展开更多
基金supported by National Key Technologies Research and Development Program of China under Grant No.2014BAH14F01National Science and Technology Major Project of China under Grant No.2012ZX03005007+1 种基金National NSF of China Grant No.61402372Fundamental Research Funds for the Central Universities Grant No.3102014JSJ0003
文摘Sensor networks tend to support different traffic patterns since more and more emerging applications have diverse needs. We present MGRP, a Multi-Gradient Routing Protocol for wireless sensor networks, which is fully distributed and efficiently supports endto-end, one-to-many and many-to-one traffic patterns by effectively construct and maintain a gradient vector for each node. We further combine neighbor link estimation with routing information to reduce packet exchange on network dynamics and node failures. We have implemented MGRP on Tiny OS and evaluated its performance on real-world testbeds. The result shows MGRP achieves lower end-to-end packet delay in different traffic patterns compared to the state of the art routing protocols while still remains high packet delivery ratio.
基金supported by the National Key R&D Program of China(2022YFB3808000)the National Natural Science Foundation of China(82402802,82404113,82302713,U23A20490)+6 种基金the China Postdoctoral Science Foundation(2023M742390)the Guangdong Basic and Applied Basic Research Foundation(2022A1515012663,2023A1515220250,2023A1515111068)the Shenzhen Science and Technology Innovation Program(RCBS20231211090537061,JCYJ20230807095203007,JCYJ20230807095121041)the Shenzhen Key Medical Discipline Construction Fund(SZXK023)the Sanming Project of Medicine in Shenzhen(SZSM202211038)the Shenzhen High-level Hospital Construction Fund,and the Scientific Research Foundation of Peking University Shenzhen Hospital(LCYJZD2021005,KYQD2023244,KYQD2023245)The authors also gratefully acknowledged the kindly financial support provided by the Youth Talent Support Program of the China Association for Science and Technology,and the Top Young Talents of Foal Eagle Program of Fujian Province to Jin Zhang.
文摘Peripheral nerve defects present complex orthopedic challenges with limited efficacy of clinical interventions.The inadequate proliferation and dysfunction of Schwann cells within the nerve scaffold impede the effectiveness of nerve repair.Our previ-ous studies suggested the effectiveness of a magnesium-encapsulated bioactive hydrogel in repairing nerve defects.However,its rapid release of magnesium ions limited its efficacy to long-term nerve regeneration,and its molecular mechanism remains unclear.This study utilized electrospinning technology to fabricate a MgO/MgCO_(3)/polycaprolactone(PCL)multi-gradient nanofiber membrane for peripheral nerve regeneration.Our findings indicated that by carefully adjusting the concentration or proportion of rapidly degradable MgO and slowly degradable MgCO_(3),as well as the number of electrospun layers,the multi-gradient scaffold effectively sustained the release of Mg^(2+)over a period of 6 weeks.Additionally,this study provided insight into the mechanism of Mg^(2+)-induced nerve regeneration and confirmed that Mg^(2+)effectively promoted Schwann cell proliferation,migration,and transition to a repair phenotype.By employing transcriptome sequencing technology,the study identified the Wingless/integrase-1(Wnt)signaling pathway as a crucial mechanism influencing Schwann cell function during nerve regeneration.After implantation in 10 mm critically sized nerve defects in rats,the MgO/MgCO_(3)/PCL multi-gradient nanofiber combined with a 3D-engineered PCL nerve conduit showed enhanced axonal regeneration,remyelination,and reinnervation of muscle tissue 12 weeks post-surgery.In conclusion,this study successfully developed an innovative multi-gradient long-acting MgO/MgCO_(3)/PCL nanofiber with a tunable Mg^(2+)release property,which underscored the molecular mechanism of magnesium-encapsulated biomaterials in treating nervous system diseases and established a robust theoretical foundation for future clinical translation.
基金funded by the Key Program of National Natural Science Foundation of China(Grant No.51734010)the Startup Fund of Changzhou University Science Research(Grant No.ZMF22020060).
文摘Multi-gradient drilling is a new offshore drilling method.The accurate calculation of the related wellbore temperature is of great significance for the prediction of the gas hydrate formation area and the precise control of the wellbore pressure.In this study,a new heat transfer model is proposed by which the variable mass flow is properly taken into account.Using this model,the effects of the main factors influencing the wellbore temperature are analyzed.The results indicate that at the position where the separation injection device is installed,the temperature increase of the fluid in the drill pipe is mitigated due to the inflow/outflow of hollow spheres,and the temperature drop of the fluid in the annulus also decreases.In addition,a lower separation efficiency of the device,a shallower installation depth and a smaller circulating displacement tend to increase the temperature near the bottom of the annulus,thereby helping to reduce the hydrate generation area and playing a positive role in the prevention and control of hydrates in deepwater drilling.
文摘现有的基于双向长短时记忆(BiLSTM)网络的命名实体识别(NER)模型难以全面理解文本的整体语义以及捕捉复杂的实体关系。因此,提出一种基于全域信息融合和多维关系感知的NER模型。首先,通过BERT(Bidirectional Encoder Representations from Transformers)获取输入序列的向量表示,并结合BiLSTM进一步学习输入序列的上下文信息。其次,提出由梯度稳定层和特征融合模块组成的全域信息融合机制:前者使模型保持稳定的梯度传播并更新优化输入序列的表示,后者则融合BiLSTM的前后向表示获取更全面的特征表示。接着,构建多维关系感知结构学习不同子空间单词的关联性,以捕获文档中复杂的实体关系。此外,使用自适应焦点损失函数动态调整不同类别实体的权重,提高模型对少数类实体的识别性能。最后,在7个公开数据集上将所提模型和11个基线模型进行对比,实验结果表明所提模型的F1值均优于对比模型,可见该模型的综合性较优。
