The Moyar-Bhavani Shear Zone(MBSZ)of the South Indian Granulite Terrain(SIGT),a complex continental block formed by the accretion of various crustal units during the Archaean to Neoproterozoic,bear evidences of
Based on various statistical indices,the abilities of multi-generation reanalyses,namely the NCEP/NCAR Reanalysis 1(R1),the NCEP-DOE Reanalysis 2(R2)and the NCEP Climate Forecast System Reanalysis(CFSR),to reproduce t...Based on various statistical indices,the abilities of multi-generation reanalyses,namely the NCEP/NCAR Reanalysis 1(R1),the NCEP-DOE Reanalysis 2(R2)and the NCEP Climate Forecast System Reanalysis(CFSR),to reproduce the spatiotemporal characteristics of precipitation over Zhejiang Province are comprehensively compared.The mean absolute bias percentages for three reanalyses are 20%(R1),10%(R2)and 37%(CFSR).R2(R1)gives the best(worst)general depiction of the spatial characteristics of the observed precipitation climatology,whereas a significant wet bias is noticed in the CFSR.All reanalyses reasonably reproduce the interannual variability with the correlation coefficients of 0.72(R1),0.72(R2)and 0.84(CFSR).All reanalyses well represent the first two modes of the observed precipitation through Empirical Orthogonal Function analysis,with CFSR giving the best capture of the principal components.The root-mean-square error(RMSE)is the largest(smallest)in the CFSR(R2).The large RMSE of CFSR in summer(especially in June)contributes mostly to its systematic wet bias.After 2001,the wet bias of CFSR substantially weakens,probably attributed to increasing observations assimilated in the CFSR.On a monthly basis,the percentage of neutral bias cases are similar for all reanalyses,while the ratio of positive(negative)bias cases for CFSR is distinctly larger(smaller)than that of R1 and R2.The proportions of negative bias cases for R1 and R2 begin to increase after 2001 while keeping stable for CFSR.On a daily basis,all reanalyses give good performances of reproducing light rain;however,the reflection of moderate rain and heavier rain by the CFSR is better than R1 and R2.Overall,despite being a third-generation reanalysis product,the CRSR does not exhibit comprehensive superiorities over R1 and R2 in all aspects on a regional scale.展开更多
In this paper,a new multi-generation system,incorporating solid oxide fuel cell(SOFC),gas turbine(GT),lithium bromide chiller,gas and heat storage components is proposed to address the issues of volatility in user loa...In this paper,a new multi-generation system,incorporating solid oxide fuel cell(SOFC),gas turbine(GT),lithium bromide chiller,gas and heat storage components is proposed to address the issues of volatility in user load and energy source input and mismatching between supply and demand.The dynamic model and control strategy of the system are established,and the system dynamic characteristics in response to solar DNI and external load disturbances are studied.The system can rapidly adjust the key output and input parameters to realize a new supply-demand balance in a shorter period of time by multiple PID control methods.The response processes of two combined cooling,heating and power(CCHP) systems with and without gas storage to cope with load changes are compared.The results show that the CCHP system with gas storage can effectively shorten the response time of load following.The solar collector and the SOFC-GT can reach a new equilibrium within a few tens of seconds under the controller.The response time of the methanol reactor is longer compared to those of solar collector and the SOFC-GT,taking several minutes to stabilize.When the cooling and heating load change,the system can adjust the output to the demand value within 500 and 260 seconds.展开更多
Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person i...Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person is a hierarchy of five needs： physiological needs, safety needs, social needs, esteem needs, and self-actualization needs Organizations must be able to identify what employees desire to secure optimum performance and to meet the needs of both employees and employers. This research focuses on the generational gap and the significance of intrinsic and extrinsic rewards in the workforce. The purpose and objective of this research are to test the significance of monetary versus non-monetary rewards among the different generations in the organization. A self-designed questionnaire distributed to a multi-generational group of employees of selected organizations was used to collect the analyzed data. Sixty-five （65%） responses were obtained. Secondary data were used to elucidate the needs in this area of study. Because the workforce is predicted to become more diverse in terms of age, organizations will be unlikely to implement one set of rewards for the multiple generations. This is due to the differing expectations and requirements among the generations. However, the results indicate no significant difference in monetary versus non-monetary rewards among the different generations in the workforce.展开更多
Under the background of population aging,while the living environment of the elderly is improved,it is necessary to pay attention to their spiritual needs and build an elderly-friendly and livable social environment.I...Under the background of population aging,while the living environment of the elderly is improved,it is necessary to pay attention to their spiritual needs and build an elderly-friendly and livable social environment.In this paper,through field investigation and research on social behavior and space,the social behavior and needs of the elderly in a university in the north were analyzed,and based on the social characteristics and psychological needs of the elderly and students in the university,the construction of a dynamic space with multi-generational shared space as the core was proposed to develop a social platform that integrates virtual and reality,so as to provide reference for the updating of social space in college communities in the future.展开更多
A tag encoding authentication scheme for network coding proposed by Wu et al was claimed to defend pollution attacks efficiently. However, we find that the scheme easily incurs multi-generation pollution attacks, wher...A tag encoding authentication scheme for network coding proposed by Wu et al was claimed to defend pollution attacks efficiently. However, we find that the scheme easily incurs multi-generation pollution attacks, where an adversary may be able to recover the main secret key of the source with high probability during multi-generation transmitting, and the scheme also cannot resist against inter-generation pollution attacks. Using a dynamic source secret key technology that the key can be updated with the change of generation identifier, an improved scheme is then presented, which can counteract these security defects without any efficiency compromise.展开更多
Environmental conditions of a parent plant can influence the performance of their clonal offspring,and such clonal transgenerational effects may help offspring adapt to different environments.However,it is still uncle...Environmental conditions of a parent plant can influence the performance of their clonal offspring,and such clonal transgenerational effects may help offspring adapt to different environments.However,it is still unclear how many vegetative generations clonal transgenerational effects can transmit for and whether it depends on the environmental conditions of the offspring.We grew the ancestor ramets of the floating clonal plant Spirodela polyrhiza under a high and a low nutrient level and obtained the so-called 1^(st)-generation offspring ramets of two types(from these two environments).Then we grew the 1^(st)-generation offspring ramets of each type under the high and the low nutrient level and obtained the so-called 2^(nd)-generation offspring ramets of four types.We repeated this procedure for another five times and analyzed clonal transgenerational effects on growth,morphology and biomass allocation of the 1^(st)-to the 6^(th)-generation offspring ramets.We found positive,negative or neutral(no)transgenerational effects of the ancestor nutrient condition on the offspring of S.polyrhiza,depending on the number of vegetative generations,the nutrient condition of the offspring environment and the traits considered.We observed significant clonal transgenerational effects on the 6^(th)-generation offspring;such effects occurred for all three types of traits(growth,morphology and allocation),but varied depending on the nutrient condition of the offspring environment and the traits considered.Our results suggest that clonal transgenerational effects can transmit for multiple vegetative generations and such impacts can vary depending on the environmental conditions of offspring.展开更多
Methane looping reforming to produce syngas is an alternative to partial methane oxidation because it allows for better control of the oxidation reaction and safely separates oxygen from syngas.However,most systems ar...Methane looping reforming to produce syngas is an alternative to partial methane oxidation because it allows for better control of the oxidation reaction and safely separates oxygen from syngas.However,most systems are monofunctional and lack the cascading utilization of energy flows,resulting in significant exergy loss.This study proposes a novel net-zero emission system that utilizes methane looping reforming for multi-generation of electricity,heating,cooling,and methanol.The reduction of high-valent manganese oxides by decoupling the partial oxidation reaction of methane into an Mn-based oxygen carrier redox cycle yielded products with H_(2)/CO ratios suitable for methanol synthesis,resulting in approximately 100%CH_(3)OH conversion rate.The oxidation of low-valent manganese oxides provides high-temperature heat for heat recovery,and the lithium bromide refrigeration section produces domestic hot and cold water as by-products.The proposed system reaches 77.1%and 65.7%energy and exergy efficiencies,which are 1.04-and 1.61-fold higher than those of traditional partial oxidation systems,respectively.Our research presents a new system integration concept that enables the efficient and controllable loop reforming of methane for methanol production.展开更多
An atmospheric test system of dual fluidized beds for coal multi-generation was built. One bubbling fluidized bed is for gasification and a circulating fluidized bed for combustion. The two beds are combined with two ...An atmospheric test system of dual fluidized beds for coal multi-generation was built. One bubbling fluidized bed is for gasification and a circulating fluidized bed for combustion. The two beds are combined with two valves： one valve to send high temperature ash from combustion bed to the gasification bed and another valve to send char and ash from gasification bed to combustion bed. Experiments on Shenhua coal multi-generation were made at temperatures from 1112 K to 1191 K in the dual fluidized beds. The temperatures of the combustor are stable and the char combustion efficiency is about 98%. Increasing air/coal ratio to the fluidized bed leads to the increase of temperature and gasification efficiency. The maximum gasification efficiency is 36.7% and the calorific value of fuel gas is 10.7 MJ/Nm^3. The tar yield in this work is 1.5%, much lower than that of pyrolysis. Carbon conversion efficiency to fuel gas and flue gas is about 90%.展开更多
Origin of garnet in skarn(magmatic vs.hydrothermal)and the prograde skarn fluid evolution are still controversial.Two generations of garnet(Grt1,Grt2)were identified at the Tongshankou deposit:Grt1 is anisotropic with...Origin of garnet in skarn(magmatic vs.hydrothermal)and the prograde skarn fluid evolution are still controversial.Two generations of garnet(Grt1,Grt2)were identified at the Tongshankou deposit:Grt1 is anisotropic with oscillatory zoning and resorbed boundary,whilst Grt2 grew around Grt1 and formed oscillatory rims.In-situ LA-ICP-MS U-Pb dating of Grt1 and Grt2 yielded a lower intercept^(206)Pb/^(238)U age of 142.4±2.8 Ma(n=57;MSWD=1.16)and 142.3±9.6 Ma(n=60;MSWD=1.06),respectively,coeval with the ore formation and ore-related granodiorite emplacement.Positive Eu anomaly,non-CHARAC Y/Ho value and low TiO_(2)content,together with the mineral assemblages indicate that both Grtl and Grt2 have a hydrothermal origin.The existence of melt and melt-fluid inclusions in Grt1,together with similar LREE-enriched patterns to the granodiorite,further indicate that Grt1 may have formed in the magmatic-hydrothermal transition.Higher U contents and LREE-enriched patterns of Grt1 indicate that fluid I is mildly acidic pH and low fO_(2).The inner gray Grt2 rims(Grt2A)is HREE-enriched with low U contents,indicating that fluid II has nearly neutral pH and high fO_(2).The wider Y/Ho range and LREE-enriched patterns of the outer light-gray Grt2 rims(Grt2B)show that the evolved magmatic fluidⅡhad mixed with an external fluid,characterized by being mildly acidic pH and with high fO_(2)·Our results suggest that the prograde skarn-forming fluids can be multistage at Tongshankou,and the mixing of meteoric water may have been prominent in the prograde skarn stage.展开更多
Based on the previous study on cultivation nutrition of Cunninghamia lanceolata plantations of first generation, the cultivation nutrition of C. lanceolata plantations with multi-generation was studied. The results sh...Based on the previous study on cultivation nutrition of Cunninghamia lanceolata plantations of first generation, the cultivation nutrition of C. lanceolata plantations with multi-generation was studied. The results show that there are significant differences in the growth, development and nutrient assimilation among C. lanceolata plantations with different generations and nutrition conditions. These differences are closely related to the land fertility decline of C. lanceolata plantations. This paper de...展开更多
Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multipl...Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways,multiple organs,and multiple targets.Its mechanisms involve direct ways such as oxidative stress,epigenetic modification,and metabolic activation,and it may also be indirectly caused by placental dysfunction.Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming,functional homeostasis changes,and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels of maternal-derived glucocorticoids.The organ developmental toxicity and programming alterations caused by medication during pregnancy may also have gender differences and multi-generational genetic effects mediated by abnormal epigenetic modification.Combined with the latest research results of our laboratory,this paper reviews the latest research progress on the developmental toxicity and functional programming alterations of multiple organs in offspring induced by medication during pregnancy,which can provide a theoretical and experimental basis for rational medication during pregnancy and effective prevention and treatment of drug-related multiple fetal-originated diseases.展开更多
文摘The Moyar-Bhavani Shear Zone(MBSZ)of the South Indian Granulite Terrain(SIGT),a complex continental block formed by the accretion of various crustal units during the Archaean to Neoproterozoic,bear evidences of
基金Zhejiang Province Basic Public Welfare Program(LGF19D050001)Key R&D Program of Zhejiang Province(2021C02036)+2 种基金China Meteorological Administration Special Fund for Forecasters(CMAYBY2019-048)National Key R&D Program of China(2018YFC1505601)Key Program of Zhejiang Meteorological Bureau(2020ZD14)。
文摘Based on various statistical indices,the abilities of multi-generation reanalyses,namely the NCEP/NCAR Reanalysis 1(R1),the NCEP-DOE Reanalysis 2(R2)and the NCEP Climate Forecast System Reanalysis(CFSR),to reproduce the spatiotemporal characteristics of precipitation over Zhejiang Province are comprehensively compared.The mean absolute bias percentages for three reanalyses are 20%(R1),10%(R2)and 37%(CFSR).R2(R1)gives the best(worst)general depiction of the spatial characteristics of the observed precipitation climatology,whereas a significant wet bias is noticed in the CFSR.All reanalyses reasonably reproduce the interannual variability with the correlation coefficients of 0.72(R1),0.72(R2)and 0.84(CFSR).All reanalyses well represent the first two modes of the observed precipitation through Empirical Orthogonal Function analysis,with CFSR giving the best capture of the principal components.The root-mean-square error(RMSE)is the largest(smallest)in the CFSR(R2).The large RMSE of CFSR in summer(especially in June)contributes mostly to its systematic wet bias.After 2001,the wet bias of CFSR substantially weakens,probably attributed to increasing observations assimilated in the CFSR.On a monthly basis,the percentage of neutral bias cases are similar for all reanalyses,while the ratio of positive(negative)bias cases for CFSR is distinctly larger(smaller)than that of R1 and R2.The proportions of negative bias cases for R1 and R2 begin to increase after 2001 while keeping stable for CFSR.On a daily basis,all reanalyses give good performances of reproducing light rain;however,the reflection of moderate rain and heavier rain by the CFSR is better than R1 and R2.Overall,despite being a third-generation reanalysis product,the CRSR does not exhibit comprehensive superiorities over R1 and R2 in all aspects on a regional scale.
基金supported by the Major Program of the National Natural Science Foundation of China (No.52090064)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (No.51821004)。
文摘In this paper,a new multi-generation system,incorporating solid oxide fuel cell(SOFC),gas turbine(GT),lithium bromide chiller,gas and heat storage components is proposed to address the issues of volatility in user load and energy source input and mismatching between supply and demand.The dynamic model and control strategy of the system are established,and the system dynamic characteristics in response to solar DNI and external load disturbances are studied.The system can rapidly adjust the key output and input parameters to realize a new supply-demand balance in a shorter period of time by multiple PID control methods.The response processes of two combined cooling,heating and power(CCHP) systems with and without gas storage to cope with load changes are compared.The results show that the CCHP system with gas storage can effectively shorten the response time of load following.The solar collector and the SOFC-GT can reach a new equilibrium within a few tens of seconds under the controller.The response time of the methanol reactor is longer compared to those of solar collector and the SOFC-GT,taking several minutes to stabilize.When the cooling and heating load change,the system can adjust the output to the demand value within 500 and 260 seconds.
文摘Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person is a hierarchy of five needs： physiological needs, safety needs, social needs, esteem needs, and self-actualization needs Organizations must be able to identify what employees desire to secure optimum performance and to meet the needs of both employees and employers. This research focuses on the generational gap and the significance of intrinsic and extrinsic rewards in the workforce. The purpose and objective of this research are to test the significance of monetary versus non-monetary rewards among the different generations in the organization. A self-designed questionnaire distributed to a multi-generational group of employees of selected organizations was used to collect the analyzed data. Sixty-five （65%） responses were obtained. Secondary data were used to elucidate the needs in this area of study. Because the workforce is predicted to become more diverse in terms of age, organizations will be unlikely to implement one set of rewards for the multiple generations. This is due to the differing expectations and requirements among the generations. However, the results indicate no significant difference in monetary versus non-monetary rewards among the different generations in the workforce.
文摘Under the background of population aging,while the living environment of the elderly is improved,it is necessary to pay attention to their spiritual needs and build an elderly-friendly and livable social environment.In this paper,through field investigation and research on social behavior and space,the social behavior and needs of the elderly in a university in the north were analyzed,and based on the social characteristics and psychological needs of the elderly and students in the university,the construction of a dynamic space with multi-generational shared space as the core was proposed to develop a social platform that integrates virtual and reality,so as to provide reference for the updating of social space in college communities in the future.
基金Supported by the National Natural Science Foundation of China(61271174,61301178)the Specific Scientific Research Plan Project of Shaanxi Education Department(15JK2150)the Science and Technology Innovation Foundation of Xi’an(CXY1352WL28,CXY1531WL38)
文摘A tag encoding authentication scheme for network coding proposed by Wu et al was claimed to defend pollution attacks efficiently. However, we find that the scheme easily incurs multi-generation pollution attacks, where an adversary may be able to recover the main secret key of the source with high probability during multi-generation transmitting, and the scheme also cannot resist against inter-generation pollution attacks. Using a dynamic source secret key technology that the key can be updated with the change of generation identifier, an improved scheme is then presented, which can counteract these security defects without any efficiency compromise.
文摘Environmental conditions of a parent plant can influence the performance of their clonal offspring,and such clonal transgenerational effects may help offspring adapt to different environments.However,it is still unclear how many vegetative generations clonal transgenerational effects can transmit for and whether it depends on the environmental conditions of the offspring.We grew the ancestor ramets of the floating clonal plant Spirodela polyrhiza under a high and a low nutrient level and obtained the so-called 1^(st)-generation offspring ramets of two types(from these two environments).Then we grew the 1^(st)-generation offspring ramets of each type under the high and the low nutrient level and obtained the so-called 2^(nd)-generation offspring ramets of four types.We repeated this procedure for another five times and analyzed clonal transgenerational effects on growth,morphology and biomass allocation of the 1^(st)-to the 6^(th)-generation offspring ramets.We found positive,negative or neutral(no)transgenerational effects of the ancestor nutrient condition on the offspring of S.polyrhiza,depending on the number of vegetative generations,the nutrient condition of the offspring environment and the traits considered.We observed significant clonal transgenerational effects on the 6^(th)-generation offspring;such effects occurred for all three types of traits(growth,morphology and allocation),but varied depending on the nutrient condition of the offspring environment and the traits considered.Our results suggest that clonal transgenerational effects can transmit for multiple vegetative generations and such impacts can vary depending on the environmental conditions of offspring.
基金supported by the Distinguish Young Scholars of the National Natural Science Foundation of China(Grant No.52225601)the Major Program of the National Natural Science Foundation of China(Grant No.52090061).
文摘Methane looping reforming to produce syngas is an alternative to partial methane oxidation because it allows for better control of the oxidation reaction and safely separates oxygen from syngas.However,most systems are monofunctional and lack the cascading utilization of energy flows,resulting in significant exergy loss.This study proposes a novel net-zero emission system that utilizes methane looping reforming for multi-generation of electricity,heating,cooling,and methanol.The reduction of high-valent manganese oxides by decoupling the partial oxidation reaction of methane into an Mn-based oxygen carrier redox cycle yielded products with H_(2)/CO ratios suitable for methanol synthesis,resulting in approximately 100%CH_(3)OH conversion rate.The oxidation of low-valent manganese oxides provides high-temperature heat for heat recovery,and the lithium bromide refrigeration section produces domestic hot and cold water as by-products.The proposed system reaches 77.1%and 65.7%energy and exergy efficiencies,which are 1.04-and 1.61-fold higher than those of traditional partial oxidation systems,respectively.Our research presents a new system integration concept that enables the efficient and controllable loop reforming of methane for methanol production.
文摘An atmospheric test system of dual fluidized beds for coal multi-generation was built. One bubbling fluidized bed is for gasification and a circulating fluidized bed for combustion. The two beds are combined with two valves： one valve to send high temperature ash from combustion bed to the gasification bed and another valve to send char and ash from gasification bed to combustion bed. Experiments on Shenhua coal multi-generation were made at temperatures from 1112 K to 1191 K in the dual fluidized beds. The temperatures of the combustor are stable and the char combustion efficiency is about 98%. Increasing air/coal ratio to the fluidized bed leads to the increase of temperature and gasification efficiency. The maximum gasification efficiency is 36.7% and the calorific value of fuel gas is 10.7 MJ/Nm^3. The tar yield in this work is 1.5%, much lower than that of pyrolysis. Carbon conversion efficiency to fuel gas and flue gas is about 90%.
基金the Guangdong Major Projects of Basic and Applied Research(2019B030302013)the National Natural Science Foundation of China(NSFC Projects Nos.42102064,42173065 and 41725009)the China Postdoctoral Science Foundation(2021M693188).
文摘Origin of garnet in skarn(magmatic vs.hydrothermal)and the prograde skarn fluid evolution are still controversial.Two generations of garnet(Grt1,Grt2)were identified at the Tongshankou deposit:Grt1 is anisotropic with oscillatory zoning and resorbed boundary,whilst Grt2 grew around Grt1 and formed oscillatory rims.In-situ LA-ICP-MS U-Pb dating of Grt1 and Grt2 yielded a lower intercept^(206)Pb/^(238)U age of 142.4±2.8 Ma(n=57;MSWD=1.16)and 142.3±9.6 Ma(n=60;MSWD=1.06),respectively,coeval with the ore formation and ore-related granodiorite emplacement.Positive Eu anomaly,non-CHARAC Y/Ho value and low TiO_(2)content,together with the mineral assemblages indicate that both Grtl and Grt2 have a hydrothermal origin.The existence of melt and melt-fluid inclusions in Grt1,together with similar LREE-enriched patterns to the granodiorite,further indicate that Grt1 may have formed in the magmatic-hydrothermal transition.Higher U contents and LREE-enriched patterns of Grt1 indicate that fluid I is mildly acidic pH and low fO_(2).The inner gray Grt2 rims(Grt2A)is HREE-enriched with low U contents,indicating that fluid II has nearly neutral pH and high fO_(2).The wider Y/Ho range and LREE-enriched patterns of the outer light-gray Grt2 rims(Grt2B)show that the evolved magmatic fluidⅡhad mixed with an external fluid,characterized by being mildly acidic pH and with high fO_(2)·Our results suggest that the prograde skarn-forming fluids can be multistage at Tongshankou,and the mixing of meteoric water may have been prominent in the prograde skarn stage.
文摘Based on the previous study on cultivation nutrition of Cunninghamia lanceolata plantations of first generation, the cultivation nutrition of C. lanceolata plantations with multi-generation was studied. The results show that there are significant differences in the growth, development and nutrient assimilation among C. lanceolata plantations with different generations and nutrition conditions. These differences are closely related to the land fertility decline of C. lanceolata plantations. This paper de...
基金supported by grants from the National Key Research and Development Program of China(No.2020YFA0803900)the National Natural Science Foundation of China(Nos.82030111 and 81673524)+2 种基金the Major Technological Innovation Projects of Hubei Province(Nos.2019ACA140 and 2020BCA071)Hubei Province’s Outstanding Medical Academic Leader programMedical Science Advancement Program(Basic Medical Sciences)of Wuhan University(No.TFJC2018001)。
文摘Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways,multiple organs,and multiple targets.Its mechanisms involve direct ways such as oxidative stress,epigenetic modification,and metabolic activation,and it may also be indirectly caused by placental dysfunction.Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming,functional homeostasis changes,and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels of maternal-derived glucocorticoids.The organ developmental toxicity and programming alterations caused by medication during pregnancy may also have gender differences and multi-generational genetic effects mediated by abnormal epigenetic modification.Combined with the latest research results of our laboratory,this paper reviews the latest research progress on the developmental toxicity and functional programming alterations of multiple organs in offspring induced by medication during pregnancy,which can provide a theoretical and experimental basis for rational medication during pregnancy and effective prevention and treatment of drug-related multiple fetal-originated diseases.
