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Exploration of multi-functional peptides with bioactive and flavorful properties in Inner Mongolian cheese by peptidomics and bioinformatics
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作者 Yuqian Zheng Zhiyong Cui +8 位作者 Shengnan Wang Chengliang Qi Amin Zhang Xueqian Guo Shilong Zhao Yuan Liu Zhihai Gao Xinya Ma Wenli Wang 《Food Science and Human Wellness》 2025年第9期3461-3471,共11页
The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidom... The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidomics and bioinformatics were used to screen flavor peptides from Inner Mongolian cheese and further assess their antioxidant and angiotensin I-converting enzyme(ACE)inhibitory properties.According to sensory data,YH8 and IL7 had detectable bitter tastes with low thresholds of 0.03 and 0.06 mmol/L,respectively.With an umami threshold range of 0.24‒0.81 mmol/L,VQ6,FK13,HP13 and QT14 exhibited a range of flavors dominated by umami,including sweet,bitter,salty,sour and kokumi.Antioxidant activity wise,YH8,VQ6,HP13 and QT14 were well represented.The above-mentioned peptides all had some ACE inhibitory effect.The bitter peptide IL7(IC_(50)=0.08 mmol/L)had the highest level of ACE inhibitory activity,followed by YH8(IC_(50)=0.33 mmol/L).These multi-functional peptides,which have been assessed for bioactive and taste features in Inner Mongolian cheese,may have positive impacts on health and harmonize the cheese’s overall flavor.These results suggest that some flavor peptides produced in fermented foods might be with bioactivities while providing a basis for the exploration and application of multi-functional peptides. 展开更多
关键词 Inner Mongolian cheese multi-functional peptides Flavor peptides ANTIOXIDANTS ACE inhibitory Molecular docking
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Corrigendum to“Multi-functional photonic spin Hall effect sensor controlled by phase transition”
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作者 Jie Cheng Rui-Zhao Li +3 位作者 Cheng Cheng Ya-Lin Zhang Sheng-Li Liu Peng Dong 《Chinese Physics B》 2025年第9期671-671,共1页
Figure 6(a)in the paper[Chin.Phys.B 33074203(2024)]was incorrect due to editorial oversight.The correct figure is provided.This modification does not affect the result presented in the paper.
关键词 CORRIGENDUM photonic spin Hall effect multi-functional sensors phase transition sensing performance
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Multi-functional SiC/Al Composites for Aerospace Applications 被引量:74
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作者 Cui Yan Wang Lifeng Ren Jianyue 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2008年第6期578-584,共7页
Multi-functional Al-matrix composites with high volume fraction (55%-57%) of SiC particles are produced with the new pressureless infiltration fabrication technology. X-ray detection and microscopic observation disp... Multi-functional Al-matrix composites with high volume fraction (55%-57%) of SiC particles are produced with the new pressureless infiltration fabrication technology. X-ray detection and microscopic observation display the composites which are macroscopically homogeneous without porosity. The investigation further reveals that the SiC/Al composites possess low density (2.94 g/cm^3), high elastic modulus (220 GPa), prominent thermal management function as a result of low coefficient of thermal expansion (8 × 10^4 K^-1) and high thermal conductivity (235 W/(m.K)) as well as unique preventability of resonance vibration. By adopting a series of developed techniques, the multi-functional SiC/Al composites have managed to be made into near-net-shape parts. Many kinds of precision components of space-based optomechanical structures and airborne optoelectronic platform have been turned out. Of them, several typical products are being under test in practices. 展开更多
关键词 COMPOSITES multi-function INFILTRATION SIC ALUMINUM aerospace applications
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Park矢量距离比驱动的异步电机匝间短路定量诊断
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作者 程建 张官祥 +3 位作者 李利华 杨欲景 何宏江 任继顺 《北京信息科技大学学报(自然科学版)》 2025年第1期88-93,共6页
现有的异步电机匝间短路故障诊断方法缺少定量化描述故障严重程度的指标,针对这一问题,提出了一种基于Park矢量法的异步电机匝间短路故障诊断方法以及相应的定量化故障特征指标。在故障状态下,Park矢量轨迹会表现出特定的畸变特征,能够... 现有的异步电机匝间短路故障诊断方法缺少定量化描述故障严重程度的指标,针对这一问题,提出了一种基于Park矢量法的异步电机匝间短路故障诊断方法以及相应的定量化故障特征指标。在故障状态下,Park矢量轨迹会表现出特定的畸变特征,能够有效区分电机的正常状态和匝间短路故障。提取Park矢量轨迹图的图形特征,以Park矢量距离比(Park vector distance ratio,PDR)来度量短路故障的严重程度。试验结果验证了该方法在匝间短路故障诊断中的有效性和准确性,为异步电机匝间短路的故障诊断研究提供了一种新思路。 展开更多
关键词 异步电机 匝间短路 故障诊断 park矢量
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Multi-functional sites catalysts based on post-synthetic modification of metal-organic frameworks 被引量:7
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作者 Dingxuan Ma Baiyan Li Zhan Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第6期827-830,共4页
Metal-organic frameworks(MOFs) are a unique class of porous crystalline materials that have shown promise for a wide range of applications. MOFs have been explored as a new type of heterogeneous catalytic materials,... Metal-organic frameworks(MOFs) are a unique class of porous crystalline materials that have shown promise for a wide range of applications. MOFs have been explored as a new type of heterogeneous catalytic materials, because of their high surface area, uniform and tunable pores, facile functionalization and incorporation of catalytic active sites. The use of multi-functional sites MOF materials as catalysts for synergistic catalysis and tandem reactions has attracted increasing attention. In this review, we aim to introduce the construction of bi-or multi-functional MOF catalysts with cooperative or cascade functions via post-synthetic modification(PSM). 展开更多
关键词 Metal-organic frameworks multi-functional sites CATALYSIS Post-synthetic modification
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从线粒体角度探讨PARK家族在慢性骨病中的研究进展 被引量:1
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作者 汪春梅 安方玉 +8 位作者 颜春鲁 柳颖 王霞霞 孙柏 张捷 肖志攀 王玉洁 常伟荣 宋佳眙 《中国现代应用药学》 北大核心 2025年第7期1216-1226,共11页
线粒体与决定细胞命运的多种生物过程密切相关,能够参与真核生物的氧化代谢、三羧酸循环、能量转化、氧化磷酸化等,其结构及功能的异常是慢性骨病发病的核心环节。研究发现,PARK家族成员能够通过介导线粒体自噬等参与慢性骨病的发生发... 线粒体与决定细胞命运的多种生物过程密切相关,能够参与真核生物的氧化代谢、三羧酸循环、能量转化、氧化磷酸化等,其结构及功能的异常是慢性骨病发病的核心环节。研究发现,PARK家族成员能够通过介导线粒体自噬等参与慢性骨病的发生发展过程,但具体分子机制未明。基于此,本文主要总结近年来PARK1、PARK2、PARK5、PARK6和PARK7等PARK家族成员介导的线粒体自噬、氧化应激、能量代谢在慢性骨病发生发展过程中的分子调控机制研究进展,以期为慢性骨病的临床诊治及靶向治疗提供依据。 展开更多
关键词 park基因家族 慢性骨病 线粒体自噬 线粒体氧化应激 线粒体能量代谢
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Design of Drilling and Riveting Multi-functional End Effector for CFRP and Aluminum Components in Robotic Aircraft Assembly 被引量:6
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作者 Zhang Lin Tian Wei +4 位作者 Li Dawei Hong Peng Li Zhenyu Zhou Weixue Liao Wenhe 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2018年第3期529-538,共10页
To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforc... To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength. 展开更多
关键词 robotic aircraft assembly CFRP and aluminum components automatic drilling and riveting multi-functional end effector online detection and adjustment
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Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer 被引量:1
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作者 Yang-Yang Wang Liang Li +4 位作者 Xiu-Jun Liu Qing-Fang Miao Yi Li Meng-Ran Zhang Yong-Su Zhen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2022年第2期232-242,共11页
Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmo... Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer. 展开更多
关键词 Pancreatic cancer Folate receptor multi-functional Macropinocytosis-enhanced BIOCONJUGATE K-RAS PEGYLATION
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Multi-functional photonic spin Hall effect sensor controlled by phase transition 被引量:1
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作者 程杰 李瑞昭 +3 位作者 程骋 张亚林 刘胜利 董鹏 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第7期336-342,共7页
Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propo... Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors. 展开更多
关键词 photonic spin Hall effect multi-functional sensors phase transition sensing performance
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改良Parks切口斜视手术后干眼症患者炎症因子与眼表功能的关系研究 被引量:1
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作者 程靖倩 王爽 覃冬 《河北医学》 2025年第1期127-132,共6页
目的:探析改良Parks切口斜视手术后干眼症患者血清炎症因子水平变化情况,并分析其与眼表功能的关联性。方法:纳入2021年3月至2024年3月本院收治的斜视患者122例,所有患者接受改良Parks切口手术,观察术后发生干眼症患者炎症因子水平变化... 目的:探析改良Parks切口斜视手术后干眼症患者血清炎症因子水平变化情况,并分析其与眼表功能的关联性。方法:纳入2021年3月至2024年3月本院收治的斜视患者122例,所有患者接受改良Parks切口手术,观察术后发生干眼症患者炎症因子水平变化,并分析其水平变化与眼表功能的关系。结果:改良Parks切口斜视手术后干眼症发生率为21.31%(26/122),术后干眼症患者血清IL-6、MMP-2、TNF-α、TLR4水平明显高于非干眼症患者,差异均有统计学意义(P<0.05);干眼症患者与非干眼症患者OSDI评分比较差异有统计学意义(P<0.05),Pearson相关性分析显示:IL-6、MMP-2、TNF-α、TLR4水平与眼表功能障碍程度成正相关性,相关性均有统计学意义(r=0.482、0.510、0.351、0.333,P<0.05);线性回归显示:IL-6、MMP-2、TNF-α、TLR4是影响眼表功能的危险因素,差异均有统计学意义(P<0.05);ROC曲线分析显示:血清IL-6、MMP-2、TNF-α、TLR4评估眼表功能障碍的AUC分别为0.668、0.752、0.743、0.766,而IL-6+MMP-2+TNF-α+TLR4四项联合评估眼表功能障碍的AUC为0.873,最大约登指数下的敏感度和特异度分别为0.769、0.854。结论:改良Parks切口斜视手术后干眼症患者血清IL-6、MMP-2、TNF-α、TLR4等因子水平异常升高,并与眼表功能障碍程度相关,对眼表功能障碍有较高的评估价值。 展开更多
关键词 斜视 改良parks切口手术 干眼症 炎症因子 眼表功能
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基于修正的Park-Ang双参数损伤模型RC剪力墙损伤性能研究
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作者 彭修宁 赵起超 邹新 《建筑结构》 北大核心 2025年第18期79-86,共8页
为了进一步提高目前Park-Ang双参数损伤模型对于RC剪力墙在剪切破坏和弯曲破坏状态下损伤性能及损伤性能评估的精确性,在总结既有关于RC剪力墙低周反复加载试验数据的基础上,总结Park-Ang双参数损伤模型中累积耗能组合系数的影响因素,... 为了进一步提高目前Park-Ang双参数损伤模型对于RC剪力墙在剪切破坏和弯曲破坏状态下损伤性能及损伤性能评估的精确性,在总结既有关于RC剪力墙低周反复加载试验数据的基础上,总结Park-Ang双参数损伤模型中累积耗能组合系数的影响因素,对RC剪力墙剪跨比、轴压比、纵筋配筋率、箍筋配筋率进行多元非线性回归分析,拟合得到考虑RC剪力墙的截面形状和约束边缘构件纵筋配筋率、配箍率影响的累计耗能组合系数修正值,给出RC剪力墙在剪切、弯曲破坏下的Park-Ang双参数损伤修正模型。结果表明:弯曲破坏状态下,对于L形、T形和工字形剪力墙,拟合出的累计耗能组合系数表达式计算出数据离散性更小;剪切破坏状态下,拟合出的累计耗能组合系数表达式计算出数据离散性更小。 展开更多
关键词 park-Ang损伤模型 RC剪力墙结构 剪切破坏 弯曲破坏 结构损伤性能
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Park法重睑成形联合同期V-Y内眦赘皮矫正术治疗单睑伴内眦赘皮疗效观察 被引量:1
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作者 付慧娟 张黎 《中国医疗美容》 2025年第1期21-24,共4页
目的探讨Park法重睑成形联合同期V-Y内眦赘皮矫正术治疗单睑伴内眦赘皮疗效观察。方法选取2023年1月至2024年7月河南省人民医院收治的单睑伴内眦赘皮患者68例,根据治疗方法分为对照组和观察组,每组34例,对照组给予Park法重睑成形术治疗... 目的探讨Park法重睑成形联合同期V-Y内眦赘皮矫正术治疗单睑伴内眦赘皮疗效观察。方法选取2023年1月至2024年7月河南省人民医院收治的单睑伴内眦赘皮患者68例,根据治疗方法分为对照组和观察组,每组34例,对照组给予Park法重睑成形术治疗,观察组另给予同期V-Y内眦赘皮矫正术治疗,对比两组美学总有效率、手术相关指标、眼裂变化、瘢痕严重程度及并发症发生率。结果治疗3个月后,观察组患者美学总有效率高于对照组(P<0.05)。两组患者手术时间、术中出血量、拆线时间、术后恢复时间比较差异无统计学意义(P>0.05)。两组患者眼裂长度均增加,且观察组更高(P<0.05)。两组倾斜度、眼裂角均降低,且观察组更低(P<0.05)。两组血管分布、色泽、厚度、柔软度评分均降低,且观察组更低(P<0.05)。两组患者并发症发生率比较差异无统计学意义(P>0.05)。结论Park法重睑成形联合同期V-Y内眦赘皮矫正术治疗单睑伴内眦赘皮患者疗效确切,能够缩短手术相关指标,改善眼裂变化,减轻瘢痕严重程度。 展开更多
关键词 park法重睑成形 V-Y内眦赘皮矫正术 单睑伴内眦赘皮
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Multi-functional optical fiber sensor system based on a dense wavelength division multiplexer
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作者 Yue-Xin Yin Zhifa Wu +4 位作者 Siwen Sun Liang Tian Xibin Wang Yuanda Wu Daming Zhang 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第7期222-224,共3页
We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain... We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain sensor, and a 48-channel DWDM.This system can monitor temperature and strain changes at the same time.The ranges of these two sensors are from-20℃ to 100℃ and from-1000 με to 2000 με, respectively.The sensitivities of the temperature sensor and strain sensor are 0.03572 nm/℃ and 0.03808 nm/N, respectively.With the aid of a broadband source and spectrometer,different kinds and ranges of parameters in the environment can be monitored by using suitable sensors. 展开更多
关键词 DENSE wavelength DIVISION multiplexer(DWDM) planar LIGHTWAVE circuit multi-functional SENSOR optical fiber SENSOR system
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A design and application of compound multi-functional sensor in wood-based panel processing
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作者 XU Kai-hong ZHOU Ding-guo 《Journal of Forestry Research》 SCIE CAS CSCD 2006年第4期319-322,共4页
A compound multi-functional sensor was designed by the study on the on-line testing technology of wood-based panels, and its properties of shape, functions, size, resistance to special environment were studied in deta... A compound multi-functional sensor was designed by the study on the on-line testing technology of wood-based panels, and its properties of shape, functions, size, resistance to special environment were studied in details. The operational principles of different sensors, technical flow of manufacturing, development of software systems of special functions, and the assessments of technical specification were also be introduced. This sensor adopted many new technologies, such as the applications of piezoresistant effect and heat sensitive effect can effectively measure the pressure and temperature, digital signal processing technology was used to extract and treat signals, and resist interference, encapsulation technology was used to keep the normal run of sensor under a harsh environment. Thus, the on-line compound multi-functional temperature/pressure sensor can be applied better to supervise the production of wood-based panels. All technical specifications of the compound multi-functional sensor were tested and the results met the requirements of the equipments. 展开更多
关键词 Wood-based panel processing multi-functional sensor Piezoresistant effect Heat sensitive effect
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Quasi-distribution Appraisal about Finite Element Analysis of Multi-functional Structure Made of Honeycomb Sandwich Materials
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作者 王一多 SHI Xiaofei +1 位作者 XI Ping LANG Haitao 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2018年第1期30-34,共5页
A new appraisal method(QDA, quasi-distribution appraisal) which could be used to evaluate the finite element analysis of multi-functional structure made of honeycomb sandwich materials is developed based on sub-sect... A new appraisal method(QDA, quasi-distribution appraisal) which could be used to evaluate the finite element analysis of multi-functional structure made of honeycomb sandwich materials is developed based on sub-section Bezier curve. It is established by simulating the distribution histogram data obtained from the numerical finite element analysis values of a satellite component with sub-section Bezier curve. Being dealt with area normalization method, the simulation curve could be regarded as a kind of probability density function(PDF), its mathematical expectation and the variance could be used to evaluate the result of finite element analysis. Numerical experiments have indicated that the QDA method demonstrates the intrinsic characteristics of the finite element analysis of multi-functional structure made of honeycomb sandwich materials, as an appraisal method, it is effective and feasible. 展开更多
关键词 honeycomb sandwich materials multi-functional structure quasi-distribution finite element analysis
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Considering calcium-binding proteins in invertebrates: multi-functional proteins that shape neuronal growth
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作者 Charles R.Tessier 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第2期208-209,共2页
Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion cha... Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion channels,sensors,and buffering proteins.Calcium can act directly by binding to signaling molecules or calcium’s effects can be indirect,for example by altering nuclear histones. 展开更多
关键词 Considering calcium-binding proteins in invertebrates multi-functional proteins that shape neuronal growth
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Analysis of Dynamic Cross Response between Spindles in a Dual Spindle Type Multi-Functional Turning Machine
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作者 Y. H. Choi S. T. Kim +1 位作者 T. Y. Seo K. H. Kim 《Journal of Power and Energy Engineering》 2013年第7期20-24,共5页
In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining proc... In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations. 展开更多
关键词 multi-functional LATHE Multi-Spindles Frequency RESPONSE CROSS RESPONSE FEM Structural ANALYSIS
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Design and Development of a Multi-functional Laparoscopic Device
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作者 Tugrul Tansug Elif Taskin +1 位作者 Eray Kurt Meltem Elitas 《Journal of Mechanics Engineering and Automation》 2019年第5期173-176,共4页
This study presents a design of a multifunctional laparoscopic appendectomy device that includes three surgical instruments commonly used in laparoscopic appendicitis surgeries:endoloop,endobag and scissors.It collect... This study presents a design of a multifunctional laparoscopic appendectomy device that includes three surgical instruments commonly used in laparoscopic appendicitis surgeries:endoloop,endobag and scissors.It collects these three independent surgical tools in a single laparoscopic appendectomy device.These days there is a trend of moving to multi-functional surgery devices during minimally invasive surgery.The main reasons behind the minimal invasive surgery are to avoid changing the devices several times during the operation,to reduce the time spent in operation,to increase the efficiency of the operation,to facilitate the follow-up of the camera and devices,and to leave trocars to be used for other surgical instruments.The multi-functional appendectomy device that,we present here,provides these benefits.The standard trocar entries are appropriate for its usage.The presented multifunctional laparoscopic appendectomy device offers more practical use in comparison to individual devices.On the other hand,development of these multi-functional surgery devices can be directly enhanced to the robotic surgery devices. 展开更多
关键词 Apendectomy multi-functional LAPAROSCOPY SOLIDWORKS SURGERY
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Design and Development of a Forest Nursery, for the Enhancement of Multi-Functional Agriculture and for a Didactical Purpose
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作者 Elena Valent Sirio Rossano Secondo Cividino +4 位作者 Marco Barbaro Luisa Dalla Costa Stefano Santi Simona Rainis Rino Gubiani 《Journal of Life Sciences》 2013年第8期892-900,共9页
The experimental idea of the present project was elaborated in order to create a structure where different categories and institutions could collaborate, with the common aim to develop a sustainable and profitable agr... The experimental idea of the present project was elaborated in order to create a structure where different categories and institutions could collaborate, with the common aim to develop a sustainable and profitable agriculture in mountain and marginal areas. The target was the recovering of an abandoned agricultural site, throughout its re-organisation, re-qualification and auto-sustainability, involving local citizens. This approach was based on three further broad functions such as environmental, economic and social purposes. This cooperation, that allows the capitalization of local knowledge and the forging of relationships between local and external sources of expertise, information and advice, is fundamental to the future of existing rural communities, in particular in mountain areas. The model proposed, with the elaboration of a management software and technical agronomic sheets, could be an incentive for the activities already present in that region and to stimulate new ones. The enhancing of the native ecological system, the biodiversity tutelage and the valorization of the knowledge of the territory is the basic requirement for the successful of any land management. 展开更多
关键词 Innovative sustainable and multi-functional agriculture recovering of disused agronomic areas biodiversity tutelage horticulture.
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Parks改良虚挂线配合TROPIS术治疗高位括约肌间肛瘘的疗效观察 被引量:3
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作者 张雁 梁力川 +1 位作者 何芳 宇汝翠 《河北医学》 2025年第1期132-138,共7页
目的:探究Parks改良虚挂线配合经肛括约肌间切开(TROPIS)术在高位括约肌间肛瘘患者中的应用效果。方法:选取2021年2月至2023年10月901医院收治的高位括约肌间肛瘘患者92例,随机数字表法分为两组,每组46例,对照组采取切开挂线术,观察组采... 目的:探究Parks改良虚挂线配合经肛括约肌间切开(TROPIS)术在高位括约肌间肛瘘患者中的应用效果。方法:选取2021年2月至2023年10月901医院收治的高位括约肌间肛瘘患者92例,随机数字表法分为两组,每组46例,对照组采取切开挂线术,观察组采取Parks改良虚挂线配合TROPIS术治疗。比较两组手术相关指标、疼痛及创面愈合、并发症、复发率及手术前后炎症应激[白介素-1(IL-1)、髓过氧化物酶(MPO)、白介素-6(IL-6)]、括约肌功能及创面局部微环境。结果:观察组术中出血量为(8.32±2.17)mL,低于对照组的(21.46±4.76)mL,手术及水肿消退、创面渗出物消失、创面完全愈合等时间分别为(35.57±6.59)min、(5.12±1.38)d、(6.24±1.96)d、(16.52±2.74)d均低于对照组的(48.26±8.17)min、(6.53±1.47)d、(7.38±1.63)d、(18.27±3.51)d,(P<0.05);术后1d、3d、7d、14d观察组疼痛评分为(4.14±0.63)d、(3.02±0.51)d、(1.84±0.53)d、(0.82±0.29)d,低于对照组的(5.35±0.56)d、(5.35±0.56)d、(3.16±0.87)d、(1.97±0.35)d,(P<0.05);术后7d、14d,观察组创面愈合优于对照组(P<0.05);术后1d、3d、7d观察组血清MPO、IL-1、IL-6水平低于对照组(P<0.05);术后7d观察组厚壁菌门比例为(86.35±3.69)%,高于对照组的(74.18±4.54)%,变形菌门、放线菌门比例为(7.25±1.00)%、(1.87±0.24)%,低于对照组的(16.37±1.36)%、(2.65±0.32)%,(P<0.05);术后1、3个月观察组Wexner失禁评分低于对照组,肛管静息压、肛管最大收缩压高于对照组(P<0.05);观察组并发症发生率8.70%低于对照组23.91%(P<0.05);随访6个月,观察组复发率2.17%与对照组10.87%相比,无显著差异(P>0.05)。结论:Parks改良虚挂线配合TROPIS术可减轻患者括约肌损伤,降低炎症应激及并发症风险,维持创面局部微环境,加速术后康复进程。 展开更多
关键词 括约肌间肛瘘 parks改良虚挂线 康复进程 经肛括约肌间切开术 创面愈合
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