The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidom...The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidomics and bioinformatics were used to screen flavor peptides from Inner Mongolian cheese and further assess their antioxidant and angiotensin I-converting enzyme(ACE)inhibitory properties.According to sensory data,YH8 and IL7 had detectable bitter tastes with low thresholds of 0.03 and 0.06 mmol/L,respectively.With an umami threshold range of 0.24‒0.81 mmol/L,VQ6,FK13,HP13 and QT14 exhibited a range of flavors dominated by umami,including sweet,bitter,salty,sour and kokumi.Antioxidant activity wise,YH8,VQ6,HP13 and QT14 were well represented.The above-mentioned peptides all had some ACE inhibitory effect.The bitter peptide IL7(IC_(50)=0.08 mmol/L)had the highest level of ACE inhibitory activity,followed by YH8(IC_(50)=0.33 mmol/L).These multi-functional peptides,which have been assessed for bioactive and taste features in Inner Mongolian cheese,may have positive impacts on health and harmonize the cheese’s overall flavor.These results suggest that some flavor peptides produced in fermented foods might be with bioactivities while providing a basis for the exploration and application of multi-functional peptides.展开更多
Urban traffic congestion is a significant challenge that contributes to high-density environments in urban areas,adversely impacting the living conditions of urban residents.The concept of urban renewal introduces new...Urban traffic congestion is a significant challenge that contributes to high-density environments in urban areas,adversely impacting the living conditions of urban residents.The concept of urban renewal introduces new requirements and challenges pertaining to urban transportation issues.To mitigate urban traffic congestion,enhance the greening rate of the city,and improve the urban environment,the concept of developing urban aerial ecological corridors is proposed.An analysis of the current state of various urban aerial corridors in different cities indicates that aerial ecological corridors effectively enhance connectivity and accessibility between different spaces,representing a significant strategy for addressing the issue of urban traffic congestion.Aerial ecological corridors have the potential to enhance the vertical space within urban environments,increase the greening rate of cities,and promote the physical and mental health of urban residents.Additionally,these corridors can improve the connectivity of habitat patches and address the developmental needs of biodiversity.Consequently,they serve as a crucial foundation for guiding the future transformation of urban development towards a healthier and greener direction.展开更多
Figure 6(a)in the paper[Chin.Phys.B 33074203(2024)]was incorrect due to editorial oversight.The correct figure is provided.This modification does not affect the result presented in the paper.
Multi-functional Al-matrix composites with high volume fraction （55%-57%） of SiC particles are produced with the new pressureless infiltration fabrication technology. X-ray detection and microscopic observation disp...Multi-functional Al-matrix composites with high volume fraction （55%-57%） of SiC particles are produced with the new pressureless infiltration fabrication technology. X-ray detection and microscopic observation display the composites which are macroscopically homogeneous without porosity. The investigation further reveals that the SiC/Al composites possess low density （2.94 g/cm^3）, high elastic modulus （220 GPa）, prominent thermal management function as a result of low coefficient of thermal expansion （8 × 10^4 K^-1） and high thermal conductivity （235 W/（m.K）） as well as unique preventability of resonance vibration. By adopting a series of developed techniques, the multi-functional SiC/Al composites have managed to be made into near-net-shape parts. Many kinds of precision components of space-based optomechanical structures and airborne optoelectronic platform have been turned out. Of them, several typical products are being under test in practices.展开更多
With the accelerated urbanization,human activities pose serious threats to species because of fragmentation.Planning conservation corridors between habitats could improve species mobility in order to address the human...With the accelerated urbanization,human activities pose serious threats to species because of fragmentation.Planning conservation corridors between habitats could improve species mobility in order to address the human disturbance.However,there are a limited number of studies that focus on assessing the effect of human activities on species movement in mountain areas as well as how to integrate different conservation models relating to conservation corridors identification.In our study,we modified the resistance model and took land use data as input parameters to quantify the impacts of human activities in mountain areas.Meanwhile,different conservation planning models,including Circuit model and Least Cost Path(LCP)algorithm,were integrated.Moreover,our approach was applied to identify giant panda corridors in Miarro nature reserve,Caopo nature reserve,and Wolong nature reserve.The results suggested that the impacts of human activities were limited in valley regions due to topography by resistance model.Secondly,Circuit model demonstrated that the conservation corridors for giant panda could not be identified between the Miarro and the Caopo nature reserves.Additionally,more detailed corridors between habitats were planned by the LCP algorithm.Furthermore,we also identified bottlenecks for migration in each corridor,indicating that human activities’interference was the primary cause.Our approach not only could connect habitats for conservation in mountain areas but also found out that the corridor could not be identified between habitats.展开更多
Metal-organic frameworks（MOFs） are a unique class of porous crystalline materials that have shown promise for a wide range of applications. MOFs have been explored as a new type of heterogeneous catalytic materials,...Metal-organic frameworks（MOFs） are a unique class of porous crystalline materials that have shown promise for a wide range of applications. MOFs have been explored as a new type of heterogeneous catalytic materials, because of their high surface area, uniform and tunable pores, facile functionalization and incorporation of catalytic active sites. The use of multi-functional sites MOF materials as catalysts for synergistic catalysis and tandem reactions has attracted increasing attention. In this review, we aim to introduce the construction of bi-or multi-functional MOF catalysts with cooperative or cascade functions via post-synthetic modification（PSM）.展开更多
Corridors are special patches with narrow and long shape, and often have the functions as transportation,protection, resources and aesthetics. Corridors in the study area can be classilied into 8 types, with a total l...Corridors are special patches with narrow and long shape, and often have the functions as transportation,protection, resources and aesthetics. Corridors in the study area can be classilied into 8 types, with a total length of 5167. 2 km, and conidor density of 1. 25 km/km2. The conidore are mainly composed of irrigation and drainag canals,the total length of which is 2794 km,about 54. 1% of all the corridors. The conidors have segmented the landscape, and changed the original situation of the natural landscapes. The types of conidors are clooely related to the landscape types they are distributed in. Canals are maily distributed in the wetland landscapes, while roads are mainly in the built-up area. Dikes are always along rivers or coastlines. The conidors are most densely distributed wherever human activity occurs most bouendy, such as in the artifical wedlands of paddy fields.展开更多
To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforc...To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength.展开更多
Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmo...Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.展开更多
Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propo...Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors.展开更多
Recent years have witnessed rapid and widespread economic growth in regions involved in China’s Belt and Road Initiative(BRI),mainly due to the construction of six economic corridors.This paper aims to quantify the l...Recent years have witnessed rapid and widespread economic growth in regions involved in China’s Belt and Road Initiative(BRI),mainly due to the construction of six economic corridors.This paper aims to quantify the levels of six economic corridors according to the socioeconomic development levels in the BRI regions.Here,a gridded socioeconomic development index was first created,and a dividing line was drawn to reveal the distribution characteristics of socioeconomic development in the BRI regions.A classification method was then applied to identify local development levels.Finally,we created an economic corridor development index(ECDI)to evaluate the progress of six economic corridors.The results reveal spatial heterogeneity within the socioeconomic groups of BRI regions,which can be roughly divided into offshore(or Part A,50.54%)and inland(or Part B,49.46%)areas.Although both parts comprise roughly the same area,over 95%of the population is located in offshore regions.The China–Mongolia–Russia Economic Corridor has the highest development index due to a stable political environment and long-running cooperation.The China–Pakistan Economic Corridor suffers from the lowest ECDI but with strong development potential.Our methods can provide critical reference and practice for the future evaluation of the level of regional development.The results of this study can offer policymakers some insight into reducing socioeconomic inequality in the BRI regions.展开更多
The rapid development of multimodal transportation system prompts travellers to choose multiple transportation modes, such as private vehicles or taxi, transit(subways or buses), or park-and-ride combinations for urba...The rapid development of multimodal transportation system prompts travellers to choose multiple transportation modes, such as private vehicles or taxi, transit(subways or buses), or park-and-ride combinations for urban trips. Traffic corridor is a major scenario that supports travellers to commute from suburban residential areas to central working areas. Studying their modal choice behaviour is receiving more and more interests. On one hand, it will guide the travellers to rationally choose their most economic and beneficial mode for urban trips. On the other hand, it will help traffic operators to make more appropriate policies to enhance the share of public transit in order to alleviate the traffic congestion and produce more economic and social benefits. To analyze the travel modal choice, a generalized cost model for three typical modes is first established to evaluate each different travel alternative. Then, random utility theory(RUT) and decision field theory(DFT) are introduced to describe the decision-making process how travellers make their mode choices. Further, some important factors that may influence the modal choice behaviour are discussed as well. To test the feasibility of the proposed model, a field test in Beijing was conducted to collect the real-time data and estimate the model parameters. The improvements in the test results and analysis show new advances in the development of travel mode choice on multimodal transportation networks.展开更多
With rapid development of air transportation,the airspace structure of the future will need to be flexible and dynamic to accommodate the increase in traffic demand.The corridors-in-the-sky has become a new technology...With rapid development of air transportation,the airspace structure of the future will need to be flexible and dynamic to accommodate the increase in traffic demand.The corridors-in-the-sky has become a new technology to support the full exploitation and utilization of airspace resources.This paper proposes a method of designing corridor,identifying congestion state,and analyzing the influence of air routes’traffic flow.From this,we have reached a number of conclusions.(1)The congestion periods present the multi-peak"wavy"scattered distributions and the peaks back-end agglomeration characteristics in the whole day.(2)The congestion segments present the structural characteristics of unbalanced coverage and concentrated distribution to the crossing points.The corridors with high congestion level present as an italic"N-shaped"frame,which presents incomplete penetration of short segments.(3)For the temporal and spatial interaction,there are two types of congestion segments,and there are some common congestion periods in different congestion segments of multiple corridors.The high-density air route plays a relatively decisive role in corridor congestion,and the influence of two directions is unbalanced.This research can provide a basis for the dynamic evaluation of China’s airspace resources and corridors construction in the future.展开更多
The problem of designing integration traffic strategies for traffic corridors with the use of ramp metering, speed limit, and route guidance is considered in this paper. As an improvement to the previous work, the pre...The problem of designing integration traffic strategies for traffic corridors with the use of ramp metering, speed limit, and route guidance is considered in this paper. As an improvement to the previous work, the presented approach has the following five features： 1） modeling traffic flow to analyze traffic characteristics under the influence of variable speed limit, on-ramp metering and guidance information; 2） building a hierarchy model to realize the integration design of traffic control and route guidance in traffic corridors; 3） devising a multi-class analytical dynamic traffic assignment （DTA） model for traffic corridors, where not only the route choice process will be different for each user-class, but also the traffic flow operations are user-class specific because the travel time characteristic for each user-class is considered; 4） predicting route choice probabilities adaptively with real-time traffic conditions and route choice behaviors corresponding to variant users, rather than assuming as pre-determined; and 5） suggesting a numerical solution algorithm of the hierarchy model presented in this paper based on the modified algorithm of iterative optimization assignment （IOA）. Preliminary numerical test demonstrates the potential of the developed model and algorithm for integration corridor control.展开更多
We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain...We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain sensor, and a 48-channel DWDM.This system can monitor temperature and strain changes at the same time.The ranges of these two sensors are from-20℃ to 100℃ and from-1000 με to 2000 με, respectively.The sensitivities of the temperature sensor and strain sensor are 0.03572 nm/℃ and 0.03808 nm/N, respectively.With the aid of a broadband source and spectrometer,different kinds and ranges of parameters in the environment can be monitored by using suitable sensors.展开更多
A compound multi-functional sensor was designed by the study on the on-line testing technology of wood-based panels, and its properties of shape, functions, size, resistance to special environment were studied in deta...A compound multi-functional sensor was designed by the study on the on-line testing technology of wood-based panels, and its properties of shape, functions, size, resistance to special environment were studied in details. The operational principles of different sensors, technical flow of manufacturing, development of software systems of special functions, and the assessments of technical specification were also be introduced. This sensor adopted many new technologies, such as the applications of piezoresistant effect and heat sensitive effect can effectively measure the pressure and temperature, digital signal processing technology was used to extract and treat signals, and resist interference, encapsulation technology was used to keep the normal run of sensor under a harsh environment. Thus, the on-line compound multi-functional temperature/pressure sensor can be applied better to supervise the production of wood-based panels. All technical specifications of the compound multi-functional sensor were tested and the results met the requirements of the equipments.展开更多
A new appraisal method（QDA, quasi-distribution appraisal） which could be used to evaluate the finite element analysis of multi-functional structure made of honeycomb sandwich materials is developed based on sub-sect...A new appraisal method（QDA, quasi-distribution appraisal） which could be used to evaluate the finite element analysis of multi-functional structure made of honeycomb sandwich materials is developed based on sub-section Bezier curve. It is established by simulating the distribution histogram data obtained from the numerical finite element analysis values of a satellite component with sub-section Bezier curve. Being dealt with area normalization method, the simulation curve could be regarded as a kind of probability density function（PDF）, its mathematical expectation and the variance could be used to evaluate the result of finite element analysis. Numerical experiments have indicated that the QDA method demonstrates the intrinsic characteristics of the finite element analysis of multi-functional structure made of honeycomb sandwich materials, as an appraisal method, it is effective and feasible.展开更多
Sustainability is popularly defined as meeting the needs of the present generation without compromising the ability of future generations to meet their own needs. Social, economic and environmental parameters are most...Sustainability is popularly defined as meeting the needs of the present generation without compromising the ability of future generations to meet their own needs. Social, economic and environmental parameters are most commonly accepted as the three pillars of sustainability. In this paper, various sustainability indicators have been identified during the construction stage for elevated transportation corridors and thereafter classified under various categories. Using fuzzy VIKOR technique, sustainability evaluation of transportation corridors is made on two selected project sites of two different government organizations using various identified sustainability indicators, i.e., a 3.2-km long elevated road project under construction from Vikaspuri to Meerabagh in West Delhi by PWD （Public Works Department） and the metro rail elevated corridor （part） from Punjabi Bagh to Mayapuri as a part of Phase 3, Line 7 by DMRC （Delhi Metro Rail Corporation）. The study is made at both sites in the midst of the construction period and it is identified that during the construction stage, the sustainability of these transportation corridors is just not limited to three pillars, but in actuality, it is much beyond that. From the study, it is inferred that the metro rail elevated corridor is a more sustainable corridor, in the context of the identified sustainability indicators.展开更多
Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion cha...Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion channels,sensors,and buffering proteins.Calcium can act directly by binding to signaling molecules or calcium’s effects can be indirect,for example by altering nuclear histones.展开更多
In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining proc...In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations.展开更多
基金supported by the central government and guides local funds for science and technology development(2022ZY0109).
文摘The naturally fermented Inner Mongolian cheese’s flavor and nutritional value make it a popular choice among customers.In this work,to create multi-functional peptides that have taste and biological activity,peptidomics and bioinformatics were used to screen flavor peptides from Inner Mongolian cheese and further assess their antioxidant and angiotensin I-converting enzyme(ACE)inhibitory properties.According to sensory data,YH8 and IL7 had detectable bitter tastes with low thresholds of 0.03 and 0.06 mmol/L,respectively.With an umami threshold range of 0.24‒0.81 mmol/L,VQ6,FK13,HP13 and QT14 exhibited a range of flavors dominated by umami,including sweet,bitter,salty,sour and kokumi.Antioxidant activity wise,YH8,VQ6,HP13 and QT14 were well represented.The above-mentioned peptides all had some ACE inhibitory effect.The bitter peptide IL7(IC_(50)=0.08 mmol/L)had the highest level of ACE inhibitory activity,followed by YH8(IC_(50)=0.33 mmol/L).These multi-functional peptides,which have been assessed for bioactive and taste features in Inner Mongolian cheese,may have positive impacts on health and harmonize the cheese’s overall flavor.These results suggest that some flavor peptides produced in fermented foods might be with bioactivities while providing a basis for the exploration and application of multi-functional peptides.
基金Sponsored by Research Team Project of Anhui Xinhua University(kytd202202)Anhui Provincial Undergraduate Innovation Training Program(S202212216146,S202212216133,S202212216138,AH202112216114)Key Project of Anhui Provincial Higher Education Scientific Research Project(Natural Science)(2022AH051861,2024AH050601).
文摘Urban traffic congestion is a significant challenge that contributes to high-density environments in urban areas,adversely impacting the living conditions of urban residents.The concept of urban renewal introduces new requirements and challenges pertaining to urban transportation issues.To mitigate urban traffic congestion,enhance the greening rate of the city,and improve the urban environment,the concept of developing urban aerial ecological corridors is proposed.An analysis of the current state of various urban aerial corridors in different cities indicates that aerial ecological corridors effectively enhance connectivity and accessibility between different spaces,representing a significant strategy for addressing the issue of urban traffic congestion.Aerial ecological corridors have the potential to enhance the vertical space within urban environments,increase the greening rate of cities,and promote the physical and mental health of urban residents.Additionally,these corridors can improve the connectivity of habitat patches and address the developmental needs of biodiversity.Consequently,they serve as a crucial foundation for guiding the future transformation of urban development towards a healthier and greener direction.
文摘Figure 6(a)in the paper[Chin.Phys.B 33074203(2024)]was incorrect due to editorial oversight.The correct figure is provided.This modification does not affect the result presented in the paper.
基金Foundation items： High-technology Research and Development Programme of China （2007AA03Z544） Aeronautical Science Foundation of China （20075221001）
文摘Multi-functional Al-matrix composites with high volume fraction （55%-57%） of SiC particles are produced with the new pressureless infiltration fabrication technology. X-ray detection and microscopic observation display the composites which are macroscopically homogeneous without porosity. The investigation further reveals that the SiC/Al composites possess low density （2.94 g/cm^3）, high elastic modulus （220 GPa）, prominent thermal management function as a result of low coefficient of thermal expansion （8 × 10^4 K^-1） and high thermal conductivity （235 W/（m.K）） as well as unique preventability of resonance vibration. By adopting a series of developed techniques, the multi-functional SiC/Al composites have managed to be made into near-net-shape parts. Many kinds of precision components of space-based optomechanical structures and airborne optoelectronic platform have been turned out. Of them, several typical products are being under test in practices.
基金funded by National Nature Science Foundation of China(Grant No.41701114)the West Light Foundation of The Chinese Academy of Sciences(Grant No.Y7R280080)the Research on Conservation and Breeding of Plant Diversity in Giant Panda National Park(Grant No.2018SZDZX0035)
文摘With the accelerated urbanization,human activities pose serious threats to species because of fragmentation.Planning conservation corridors between habitats could improve species mobility in order to address the human disturbance.However,there are a limited number of studies that focus on assessing the effect of human activities on species movement in mountain areas as well as how to integrate different conservation models relating to conservation corridors identification.In our study,we modified the resistance model and took land use data as input parameters to quantify the impacts of human activities in mountain areas.Meanwhile,different conservation planning models,including Circuit model and Least Cost Path(LCP)algorithm,were integrated.Moreover,our approach was applied to identify giant panda corridors in Miarro nature reserve,Caopo nature reserve,and Wolong nature reserve.The results suggested that the impacts of human activities were limited in valley regions due to topography by resistance model.Secondly,Circuit model demonstrated that the conservation corridors for giant panda could not be identified between the Miarro and the Caopo nature reserves.Additionally,more detailed corridors between habitats were planned by the LCP algorithm.Furthermore,we also identified bottlenecks for migration in each corridor,indicating that human activities’interference was the primary cause.Our approach not only could connect habitats for conservation in mountain areas but also found out that the corridor could not be identified between habitats.
基金supported by the National Natural Science Foundation of China (Nos. 21371069 and 21621001)
文摘Metal-organic frameworks（MOFs） are a unique class of porous crystalline materials that have shown promise for a wide range of applications. MOFs have been explored as a new type of heterogeneous catalytic materials, because of their high surface area, uniform and tunable pores, facile functionalization and incorporation of catalytic active sites. The use of multi-functional sites MOF materials as catalysts for synergistic catalysis and tandem reactions has attracted increasing attention. In this review, we aim to introduce the construction of bi-or multi-functional MOF catalysts with cooperative or cascade functions via post-synthetic modification（PSM）.
文摘Corridors are special patches with narrow and long shape, and often have the functions as transportation,protection, resources and aesthetics. Corridors in the study area can be classilied into 8 types, with a total length of 5167. 2 km, and conidor density of 1. 25 km/km2. The conidore are mainly composed of irrigation and drainag canals,the total length of which is 2794 km,about 54. 1% of all the corridors. The conidors have segmented the landscape, and changed the original situation of the natural landscapes. The types of conidors are clooely related to the landscape types they are distributed in. Canals are maily distributed in the wetland landscapes, while roads are mainly in the built-up area. Dikes are always along rivers or coastlines. The conidors are most densely distributed wherever human activity occurs most bouendy, such as in the artifical wedlands of paddy fields.
基金supported by the National Natural Science Foundations of China(Nos.5157051626,51475225)
文摘To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength.
基金supported by grants from CAMS Innovation Fund for Medical Sciences(Grant No.:2021-I2M-1-026)Scientific Research Project of Tianjin Education Commission(Grant No.:2020KJ140)Tianjin Health Research Project(Grant No.:KJ20017)。
文摘Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.
基金Project supported by the National Natural Science Foundation of China(Grant No.NSFC 12175107)the Natural Science Foundation of Nanjing Vocational University of Industry Technology,China(Grant No.YK22-02-08)+3 种基金the Qing Lan Project of Jiangsu Province,Chinathe Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(Grant No.KYCX23_0964)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20230347)the Fund from the Research Center of Industrial Perception and Intelligent Manufacturing Equipment Engineering of Jiangsu Province,China(Grant No.ZK21-05-09)。
文摘Photonic spin Hall effect(PSHE), as a novel physical effect in light–matter interaction, provides an effective metrological method for characterizing the tiny variation in refractive index(RI). In this work, we propose a multi-functional PSHE sensor based on VO_(2), a material that can reveal the phase transition behavior. By applying thermal control, the mutual transformation into different phase states of VO_(2) can be realized, which contributes to the flexible switching between multiple RI sensing tasks. When VO_(2) is insulating, the ultrasensitive detection of glucose concentrations in human blood is achieved. When VO_(2) is in a mixed phase, the structure can be designed to distinguish between the normal cells and cancer cells through no-label and real-time monitoring. When VO_(2) is metallic, the proposed PSHE sensor can act as an RI indicator for gas analytes. Compared with other multi-functional sensing devices with the complex structures, our design consists of only one analyte and two VO_(2) layers, which is very simple and elegant. Therefore, the proposed VO_(2)-based PSHE sensor has outstanding advantages such as small size, high sensitivity, no-label, and real-time detection, providing a new approach for investigating tunable multi-functional sensors.
基金The Strategic Priority Research Program of the Chinese Academy of Sciences,No.XDA20010203The Second Tibetan Plateau Scientific Expedition and Research Program,No.2019QZKK1006+1 种基金National Natural Science Foundation of China,No.42130508The Chinese Academy of Sciences,No.ZDRW-XH-2021-3。
文摘Recent years have witnessed rapid and widespread economic growth in regions involved in China’s Belt and Road Initiative(BRI),mainly due to the construction of six economic corridors.This paper aims to quantify the levels of six economic corridors according to the socioeconomic development levels in the BRI regions.Here,a gridded socioeconomic development index was first created,and a dividing line was drawn to reveal the distribution characteristics of socioeconomic development in the BRI regions.A classification method was then applied to identify local development levels.Finally,we created an economic corridor development index(ECDI)to evaluate the progress of six economic corridors.The results reveal spatial heterogeneity within the socioeconomic groups of BRI regions,which can be roughly divided into offshore(or Part A,50.54%)and inland(or Part B,49.46%)areas.Although both parts comprise roughly the same area,over 95%of the population is located in offshore regions.The China–Mongolia–Russia Economic Corridor has the highest development index due to a stable political environment and long-running cooperation.The China–Pakistan Economic Corridor suffers from the lowest ECDI but with strong development potential.Our methods can provide critical reference and practice for the future evaluation of the level of regional development.The results of this study can offer policymakers some insight into reducing socioeconomic inequality in the BRI regions.
基金Project(2012CB725405)supported in part by National Basic Research Program of ChinaProject(2014BAG03B01)supported by the National Science and Technology Support Program,China+1 种基金Project(71301083)supported by the National Natural Science Foundation of ChinaProject(20131089307)supported by the Project Supported by Tsinghua University,China
文摘The rapid development of multimodal transportation system prompts travellers to choose multiple transportation modes, such as private vehicles or taxi, transit(subways or buses), or park-and-ride combinations for urban trips. Traffic corridor is a major scenario that supports travellers to commute from suburban residential areas to central working areas. Studying their modal choice behaviour is receiving more and more interests. On one hand, it will guide the travellers to rationally choose their most economic and beneficial mode for urban trips. On the other hand, it will help traffic operators to make more appropriate policies to enhance the share of public transit in order to alleviate the traffic congestion and produce more economic and social benefits. To analyze the travel modal choice, a generalized cost model for three typical modes is first established to evaluate each different travel alternative. Then, random utility theory(RUT) and decision field theory(DFT) are introduced to describe the decision-making process how travellers make their mode choices. Further, some important factors that may influence the modal choice behaviour are discussed as well. To test the feasibility of the proposed model, a field test in Beijing was conducted to collect the real-time data and estimate the model parameters. The improvements in the test results and analysis show new advances in the development of travel mode choice on multimodal transportation networks.
基金National Natural Science Foundation of China,No.41671121
文摘With rapid development of air transportation,the airspace structure of the future will need to be flexible and dynamic to accommodate the increase in traffic demand.The corridors-in-the-sky has become a new technology to support the full exploitation and utilization of airspace resources.This paper proposes a method of designing corridor,identifying congestion state,and analyzing the influence of air routes’traffic flow.From this,we have reached a number of conclusions.(1)The congestion periods present the multi-peak"wavy"scattered distributions and the peaks back-end agglomeration characteristics in the whole day.(2)The congestion segments present the structural characteristics of unbalanced coverage and concentrated distribution to the crossing points.The corridors with high congestion level present as an italic"N-shaped"frame,which presents incomplete penetration of short segments.(3)For the temporal and spatial interaction,there are two types of congestion segments,and there are some common congestion periods in different congestion segments of multiple corridors.The high-density air route plays a relatively decisive role in corridor congestion,and the influence of two directions is unbalanced.This research can provide a basis for the dynamic evaluation of China’s airspace resources and corridors construction in the future.
基金supported by the National Natural Science Foundation of China (No.50808025)the Ministry of Communications of China Application Foundation (No.2006319815080)+1 种基金the Key Project of Hunan Education Department (No.08A003)the Project of Hunan Science and Technology Department (No.2008GK3114)
文摘The problem of designing integration traffic strategies for traffic corridors with the use of ramp metering, speed limit, and route guidance is considered in this paper. As an improvement to the previous work, the presented approach has the following five features： 1） modeling traffic flow to analyze traffic characteristics under the influence of variable speed limit, on-ramp metering and guidance information; 2） building a hierarchy model to realize the integration design of traffic control and route guidance in traffic corridors; 3） devising a multi-class analytical dynamic traffic assignment （DTA） model for traffic corridors, where not only the route choice process will be different for each user-class, but also the traffic flow operations are user-class specific because the travel time characteristic for each user-class is considered; 4） predicting route choice probabilities adaptively with real-time traffic conditions and route choice behaviors corresponding to variant users, rather than assuming as pre-determined; and 5） suggesting a numerical solution algorithm of the hierarchy model presented in this paper based on the modified algorithm of iterative optimization assignment （IOA）. Preliminary numerical test demonstrates the potential of the developed model and algorithm for integration corridor control.
基金Project supported by the National Key Research and Development Program of China(Grant No.2016YFB0402504)the National Natural Science Foundation of China(Grant Nos.61875069 and 61575076)+1 种基金Hong Kong Scholars Program,China(Grant No.XJ2016026)the Science and Technology Development Plan of Jilin Province,China(Grant Nos.20190302010GX and 20160520091JH)
文摘We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain sensor, and a 48-channel DWDM.This system can monitor temperature and strain changes at the same time.The ranges of these two sensors are from-20℃ to 100℃ and from-1000 με to 2000 με, respectively.The sensitivities of the temperature sensor and strain sensor are 0.03572 nm/℃ and 0.03808 nm/N, respectively.With the aid of a broadband source and spectrometer,different kinds and ranges of parameters in the environment can be monitored by using suitable sensors.
基金This project was supported by China Postdoctoral Science Funds, Jiangsu Planned Projects for Postdoctoral Research Funds and Northeast Forestry University Research Funds.
文摘A compound multi-functional sensor was designed by the study on the on-line testing technology of wood-based panels, and its properties of shape, functions, size, resistance to special environment were studied in details. The operational principles of different sensors, technical flow of manufacturing, development of software systems of special functions, and the assessments of technical specification were also be introduced. This sensor adopted many new technologies, such as the applications of piezoresistant effect and heat sensitive effect can effectively measure the pressure and temperature, digital signal processing technology was used to extract and treat signals, and resist interference, encapsulation technology was used to keep the normal run of sensor under a harsh environment. Thus, the on-line compound multi-functional temperature/pressure sensor can be applied better to supervise the production of wood-based panels. All technical specifications of the compound multi-functional sensor were tested and the results met the requirements of the equipments.
基金Funded by the National Natural Science Foundation of China(No.61471024)National Marine Technology Program for Public Welfare,China(No.201505002-1)
文摘A new appraisal method（QDA, quasi-distribution appraisal） which could be used to evaluate the finite element analysis of multi-functional structure made of honeycomb sandwich materials is developed based on sub-section Bezier curve. It is established by simulating the distribution histogram data obtained from the numerical finite element analysis values of a satellite component with sub-section Bezier curve. Being dealt with area normalization method, the simulation curve could be regarded as a kind of probability density function（PDF）, its mathematical expectation and the variance could be used to evaluate the result of finite element analysis. Numerical experiments have indicated that the QDA method demonstrates the intrinsic characteristics of the finite element analysis of multi-functional structure made of honeycomb sandwich materials, as an appraisal method, it is effective and feasible.
文摘Sustainability is popularly defined as meeting the needs of the present generation without compromising the ability of future generations to meet their own needs. Social, economic and environmental parameters are most commonly accepted as the three pillars of sustainability. In this paper, various sustainability indicators have been identified during the construction stage for elevated transportation corridors and thereafter classified under various categories. Using fuzzy VIKOR technique, sustainability evaluation of transportation corridors is made on two selected project sites of two different government organizations using various identified sustainability indicators, i.e., a 3.2-km long elevated road project under construction from Vikaspuri to Meerabagh in West Delhi by PWD （Public Works Department） and the metro rail elevated corridor （part） from Punjabi Bagh to Mayapuri as a part of Phase 3, Line 7 by DMRC （Delhi Metro Rail Corporation）. The study is made at both sites in the midst of the construction period and it is identified that during the construction stage, the sustainability of these transportation corridors is just not limited to three pillars, but in actuality, it is much beyond that. From the study, it is inferred that the metro rail elevated corridor is a more sustainable corridor, in the context of the identified sustainability indicators.
文摘Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion channels,sensors,and buffering proteins.Calcium can act directly by binding to signaling molecules or calcium’s effects can be indirect,for example by altering nuclear histones.
文摘In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations.
