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Multi-frequency non-reciprocal optical directional amplifier realized with non-Hermitian resonator arrays
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作者 Jin-Xiang Xue Chuan-Xun Du +2 位作者 Cheng-Chao Liu Liu Yang Yong-Long Wang 《Chinese Physics B》 2026年第2期423-432,共10页
For a multi-frequency non-reciprocal optical device,we first realize multi-frequency optical non-reciprocal transmission using a non-Hermitian multi-mode resonator array.Practically,multi-frequency operation can add c... For a multi-frequency non-reciprocal optical device,we first realize multi-frequency optical non-reciprocal transmission using a non-Hermitian multi-mode resonator array.Practically,multi-frequency operation can add channels to the non-reciprocal optical device and the non-reciprocity can route optical signals and prevent the reverse flow of noise.Using the Scully–Lamb model and gain saturation effect,we accomplish dual-frequency non-reciprocal transmission by introducing nonlinearity into a linear array of four-mode resonators.The accomplishment is directly demonstrated by the non-reciprocal transmission phenomena present in the non-divergent peaks.For example,a directional cyclic amplifier is constructed with non-reciprocal units.Regarding potential applications,non-reciprocal optical systems can be employed in dual-frequency control,parallel information processing,photonic integrated circuits,optical devices and so on. 展开更多
关键词 non-Hermitian systems PT-SYMMETRY multi-frequency of non-reciprocity optical directional amplifier
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Bi-Bi_(2)Ti_(2)O_(7) ohmic junction:Dual electron channels driving efficient photocatalytic nitrogen fixation
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作者 Pengkun Li Runjie Wu +5 位作者 Shuai Gao Zeping Qin Mingming Sun Changzheng Wang Wenming Sun Qiang Wang 《Chinese Chemical Letters》 2026年第1期563-569,共7页
Photocatalysis uses solar energy to convert nitrogen and water directly into ammonia,helping reduce dependence on fossil fuels and offering a way to integrate the nitrogen cycle into a clean energy network.Ohmic junct... Photocatalysis uses solar energy to convert nitrogen and water directly into ammonia,helping reduce dependence on fossil fuels and offering a way to integrate the nitrogen cycle into a clean energy network.Ohmic junctions between metals and semiconductors have demonstrated significant advantages in enhancing stability and reducing carrier recombination,but their application in photocatalytic nitrogen fixation is limited due to the difficulty of work function matching and the complexity of fabrication processes.In this study,density functional theory(DFT) calculations were used to confirm the work function matching between Bi and Bi_(2)Ti_(2)O_(7)(BTO),ensuring the formation of an Ohmic junction.A Bi-Bi_(2)Ti_(2)O_(7)(B-BTO) composite was successfully synthesized via a one-step hydrothermal method,using bismuth nitrate and titanium sulfate as precursors.Compared to pure BTO,the B-BTO heterojunction,driven by dual electron injection from both metal Bi and BTO,significantly increased the ammonia synthesis rate to 686.95 μmol g^(-1)h^(-1),making it the most active nitrogen fixation material among similar pyrochlorebased catalysts to date.The differential charge density calculations,photocurrent(i-t) measurements,and photoluminescence(PL) tests further validate the role of Ohmic contacts in enhancing charge transfer and prolonging carrier lifetimes.This research provides valuable insight into the application of Ohmic junctions in photocatalytic nitrogen fixation and contributes to advancements in this field. 展开更多
关键词 PHOTOCATALYTIC N_(2)fixation Ohmic junction Dual electron channels Bi_(2)Ti_(2)O_(7)
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On Multi-Frequency Channel Interference Alignment of 3 Channels and 4 Users 被引量:1
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作者 DU Guanglong ZOU Weixia ZHOU Zheng 《China Communications》 SCIE CSCD 2016年第1期22-32,共11页
This paper explores the multi-frequency independent channel interference alignment(MFC-IA)system of 3 channels and4 users,and single data stream transmit,i.e.(3×3,1)~4 system.We derive the analytic solution for(3... This paper explores the multi-frequency independent channel interference alignment(MFC-IA)system of 3 channels and4 users,and single data stream transmit,i.e.(3×3,1)~4 system.We derive the analytic solution for(3×3,1)~4 MFC-IA system.Based on the analytic solution,an optimization problem is proposed aim at the optimal IA solution.Then based on such a math model,we propose a simulated annealing(SA)algorithm to search optimal IA solution.The simulation results show that the simulated annealing IA algorithm has a better sum rate performance than iterative maximize signal to interference plus noise ratio(Max-SINR)algorithm.This result can be extended to single data stream multi-antenna IA system with 3 antennas and4 users. 展开更多
关键词 communication and inform ation system interference alignment multi-fre-quency channel analytic solution simulated annealing
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Multi-frequency formation mechanism and modulation strategy of self-priming enhanced submerged pulsed waterjet 被引量:1
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作者 Haojie Jia Yanwei Liu +6 位作者 Weiqin Zuo Hongkai Han Ping Chang Mohammad Waqar Ali Asad Guozhong Hu Jian Miao Hani SMitri 《International Journal of Mining Science and Technology》 2025年第2期175-189,共15页
Under submerged conditions, compared with traditional self-excited oscillating pulsed waterjets(SOPWs), annular fluid-enhanced self-excited oscillating pulsed waterjets(AFESOPWs) exhibit a higher surge pressure throug... Under submerged conditions, compared with traditional self-excited oscillating pulsed waterjets(SOPWs), annular fluid-enhanced self-excited oscillating pulsed waterjets(AFESOPWs) exhibit a higher surge pressure through self-priming. However, their pressure frequency and cavitation characteristics remain unclear, resulting in an inability to fully utilize resonance and cavitation erosion to break coal and rock. In this study, high-frequency pressure testing, high-speed photography, and large eddy simulation(LES) are used to investigate the distribution of the pressure frequency band, evolution law of the cavitation cloud, and its regulation mechanism of a continuous waterjet, SOPW, and AFESOPW. The results indicated that the excitation of the plunger pump, shearing layer vortex, and bubble collapse corresponded to the three high-amplitude frequency bands of the waterjet pressure. AFESOPWs have an additional self-priming frequency that can produce a larger amplitude under a synergistic effect with the second high-amplitude frequency band. A better cavitation effect was produced after self-priming the annulus fluid, and the shedding frequency of the cavitation clouds of the three types of waterjets was linearly related to the cavitation number. The peak pressure of the waterjet and cavitation erosion effect can be improved by modulating the waterjet pressure oscillation frequency and cavitation shedding frequency. 展开更多
关键词 multi-frequency Modulation SELF-PRIMING Submerged waterjet CAVITATION
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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders
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作者 Qing Qiu Mengting Yang +2 位作者 Danfeng Gong Haiying Liang Tingting Chen 《Neural Regeneration Research》 SCIE CAS 2025年第5期1258-1276,共19页
The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central n... The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems. 展开更多
关键词 ASTROCYTES calcium channels central nervous system extracellular ion concentration MICROGLIA neurological disorders NEURONS potassium channels
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Irreversibility analysis and multiple cubic regression based efficiency evaluation of ternary nanofluids(TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O and TiO_(2)+SiO_(2)+Cu/H_(2)O)via converging/diverging channels 被引量:1
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作者 Siddhant Taneja Sapna Sharma Bhuvaneshvar Kumar 《Acta Mechanica Sinica》 2025年第6期63-75,共13页
This study numerically examines the heat and mass transfer characteristics of two ternary nanofluids via converging and diverg-ing channels.Furthermore,the study aims to assess two ternary nanofluids combinations to d... This study numerically examines the heat and mass transfer characteristics of two ternary nanofluids via converging and diverg-ing channels.Furthermore,the study aims to assess two ternary nanofluids combinations to determine which configuration can provide better heat and mass transfer and lower entropy production,while ensuring cost efficiency.This work bridges the gap be-tween academic research and industrial feasibility by incorporating cost analysis,entropy generation,and thermal efficiency.To compare the velocity,temperature,and concentration profiles,we examine two ternary nanofluids,i.e.,TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O and TiO_(2)+SiO_(2)+Cu/H_(2)O,while considering the shape of nanoparticles.The velocity slip and Soret/Dufour effects are taken into consideration.Furthermore,regression analysis for Nusselt and Sherwood numbers of the model is carried out.The Runge-Kutta fourth-order method with shooting technique is employed to acquire the numerical solution of the governed system of ordinary differential equations.The flow pattern attributes of ternary nanofluids are meticulously examined and simulated with the fluc-tuation of flow-dominating parameters.Additionally,the influence of these parameters is demonstrated in the flow,temperature,and concentration fields.For variation in Eckert and Dufour numbers,TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O has a higher temperature than TiO_(2)+SiO_(2)+Cu/H_(2)O.The results obtained indicate that the ternary nanofluid TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O has a higher heat transfer rate,lesser entropy generation,greater mass transfer rate,and lower cost than that of TiO_(2)+SiO_(2)+Cu/H_(2)O ternary nanofluid. 展开更多
关键词 Converging/Diverging channels Ternary nanofluids Multiple cubic regression Entropy generation
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Vertical channels enable excellent lithium storage kinetics and cycling stability in silicon/carbon thick electrode 被引量:1
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作者 Wen Zhang Zihan Zhang +13 位作者 Xinxin Wang Wanming Li Qin Chen Wangting Zhong Junhong Wei Zihe Chen Shuibin Tu Xiancheng Wang Yuchen Tan Yun Zhang Huiqiao Li Yongming Sun Huamin Zhou Hui Yang 《Carbon Energy》 2025年第2期54-65,共12页
Constructing silicon(Si)-based composite electrodes that possess high energy density,long cycle life,and fast charging capability simultaneously is critical for the development of high performance lithium-ion batterie... Constructing silicon(Si)-based composite electrodes that possess high energy density,long cycle life,and fast charging capability simultaneously is critical for the development of high performance lithium-ion batteries for mitigating range anxiety and slow charging issues in new energy vehicles.Herein,a thick silicon/carbon composite electrode with vertically aligned channels in the thickness direction(VC-SC)is constructed by employing a bubble formation method.Both experimental characterizations and theoretical simulations confirm that the obtained vertical channel structure can effectively address the problem of sluggish ion transport caused by high tortuosity in conventional thick electrodes,conspicuously enhance reaction kinetics,reduce polarization and side reactions,mitigate stress,increase the utilization of active materials,and promote cycling stability of the thick electrode.Consequently,when paired with LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622),the VC-SC||NCM622 pouch type full cell(~6.0 mAh cm^(-2))exhibits significantly improved rate performance and capacity retention compared with the SC||NCM622 full cell with the conventional silicon/carbon composite electrode without channels(SC)as the anode.The assembled VC-SC||NCM622 pouch full cell with a high energy density of 490.3 Wh kg^(-1)also reveals a remarkable fast charging capability at a high current density of 2.0 mA cm^(-2),with a capacity retention of 72.0%after 500 cycles. 展开更多
关键词 high transport kinetics silicon/carbon anode structural stability thick electrode vertical channels
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Structural insights into the plant mechanosensitive ion channels OSCA2.2 and OSCA3.1
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作者 Yue Guan Yongxiang Gao +1 位作者 Xin Liu Linfeng Sun 《中国科学技术大学学报》 北大核心 2025年第6期2-9,1,I0001,共10页
Mechanosensitive ion channels are essential for sensing and converting mechanical forces into electrical or chemical signals.These channels are widely distributed across bacteria,animals,and plants.In Arabidopsis thal... Mechanosensitive ion channels are essential for sensing and converting mechanical forces into electrical or chemical signals.These channels are widely distributed across bacteria,animals,and plants.In Arabidopsis thaliana,the OSCA family has been identified as mechanically activated ion channels that respond to osmotic stress by allowing calcium ions to enter the cell.This influx increases the cytoplasmic calcium concentration,triggering osmotic stress-induced signal transduction cascades in plants.In this study,we determined the structures of OSCA2.2 and OSCA3.1 via cryoelectron microscopy(cryo-EM).Both proteins form homodimers consisting of 11 transmembrane helices(TM1–11).The ion conduction pathway is formed by TM4–8.Despite belonging to the same family,OSCA2.2 and OSCA3.1 exhibit notable structural variations.Structural analysis revealed that both OSCA2.2 and OSCA3.1 exhibit a closed conformation.We also conducted functional studies on OSCA proteins via electrophysiological experiments and confirmed the role of key amino acids in the process of ion permeation. 展开更多
关键词 calcium ion mechanosensitive ion channel OSCA2.2 OSCA3.1 CRYO-EM
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A Machine Learning-Based Channel Data Enhancement Platform for Digital Twin Channels
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作者 AI Bo ZHANG Yuxin +2 位作者 YANG Mi HE Ruisi GUO Rongge 《ZTE Communications》 2025年第2期20-30,共11页
Reliable channel data helps characterize the limitations and performance boundaries of communication technologies accurately.However,channel measurement is highly costly and time-consuming,and taking actual measuremen... Reliable channel data helps characterize the limitations and performance boundaries of communication technologies accurately.However,channel measurement is highly costly and time-consuming,and taking actual measurement as the only channel data source may reduce efficiency because of the constraints of high testing difficulty and limited data volume.Although existing standard channel models can generate channel data,their authenticity and diversity cannot be guaranteed.To address this,we use deep learning methods to learn the attributes of limited measured data and propose a generative model based on generative adversarial networks to rapidly synthesize data.A software simulation platform is also established to verify that the proposed model can generate data that are statistically similar to the measured data while maintaining necessary randomness.The proposed algorithm and platform can be applied to channel data enhancement and serve channel modeling and algorithm evaluation applications with urgent needs for data. 展开更多
关键词 channel measurement channel modeling deep learning data enhancement
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Nonlinear Resonance Response of Suspended Cables Under Multi-Frequency Excitations and Time-Delayed Feedback
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作者 Jian Peng Hui Xia +2 位作者 Lianhua Wang Xiaoyu Zhang Xianzhong Xie 《Acta Mechanica Solida Sinica》 2025年第4期689-700,共12页
This study investigates the nonlinear resonance responses of suspended cables subjected to multi-frequency excitations and time-delayed feedback.Two specific combinations and simultaneous resonances are selected for d... This study investigates the nonlinear resonance responses of suspended cables subjected to multi-frequency excitations and time-delayed feedback.Two specific combinations and simultaneous resonances are selected for detailed examination.Initially,utilizing Hamilton’s variational principle,a nonlinear vibration control model of suspended cables under multi-frequency excitations and longitudinal time-delayed velocity feedback is developed,and the Galerkin method is employed to obtain the discrete model.Subsequently,focusing solely on single-mode discretization,analytical solutions for the two simultaneous resonances are derived using the method of multiple scales.The frequency response equations are derived,and the stability analysis is presented for two simultaneous resonance cases.The results demonstrate that suspended cables exhibit complex nonlinearity under multi-frequency excitations.Multiple solutions under multi-frequency excitation can be distinguished through the frequency–response and the detuning-phase curves.By adjusting the control gain and time delay,the resonance range,response amplitude,and phase of suspended cables can be modified. 展开更多
关键词 Suspended cables multi-frequency excitation Time-delayed feedback Nonlinear resonance response
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Multi-frequency Jitter Detection and Modeling for Remote Sensing Satellite Platforms Using Non-collinear TDI CCD
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作者 ZHU Ying LI Xiaoqian +3 位作者 DONG Yanling GUI Yuhao LIAO Xiangjun ZHANG Xin 《Transactions of Nanjing University of Aeronautics and Astronautics》 2025年第5期601-614,共14页
The advancement of imaging resolution has made the impact of multi-frequency composite jitter in satellite platforms on non-collinear time delay and integration(TDI)charge-coupled device(CCD)imaging systems increasing... The advancement of imaging resolution has made the impact of multi-frequency composite jitter in satellite platforms on non-collinear time delay and integration(TDI)charge-coupled device(CCD)imaging systems increasingly critical.Moreover,the accuracy of jitter detection is constrained by the limited inter-chip overlap region inherent to non-collinear TDI CCDs.To address these challenges,a multi-frequency jitter detection method is proposed,achieving sub-pixel level error extraction.Furthermore,a multi-frequency jitter fitting approach utilizing a scale-adjustable sliding window is introduced.For composite multi-frequency jitter,spectral analysis decomposes the relative jitter error curve,while the scale-adjustable sliding window enables frequency-division fitting and modeling.Validation experiments using Gaofen-8(GF-8)remote sensing satellite imagery detected jitter at 0.65,20,and 100 Hz in the cross-track direction and at 0.5,100,and 120 Hz in the along-track direction,demonstrating the method’s precision in detecting platform jitter at sub-pixel accuracy(<0.2 pixels)and its efficacy in fitting and modeling for non-collinear TDI CCD imaging systems subject to multi-frequency jitter. 展开更多
关键词 remote sensing image matching platform jitter non-collinear TDI CCD multi-frequency jitter fitting
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Discovery of E0199:A novel compound targeting both peripheral Na_(V)and K_(V)7 channels to alleviate neuropathic pain
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作者 Boxuan Zhang Xiaoxing Shi +12 位作者 Xingang Liu Yan Liu Xuedong Li Qi Wang Dongyang Huang Weidong Zhao Junru Cui Yawen Cao Xu Chai Jiahao Wang Yang Zhang Xiangyu Wang Qingzhong Jia 《Journal of Pharmaceutical Analysis》 2025年第1期244-261,共18页
This research study focuses on addressing the limitations of current neuropathic pain(NP)treatments by developing a novel dual-target modulator,E0199,targeting both Na_(V)1.7,Na_(V)1.8,and Na_(V)1.9 and K_(V)7 channel... This research study focuses on addressing the limitations of current neuropathic pain(NP)treatments by developing a novel dual-target modulator,E0199,targeting both Na_(V)1.7,Na_(V)1.8,and Na_(V)1.9 and K_(V)7 channels,a crucial regulator in controlling NP symptoms.The objective of the study was to synthesize a compound capable of modulating these channels to alleviate NP.Through an experimental design involving both in vitro and in vivo methods,E0199 was tested for its efficacy on ion channels and its therapeutic potential in a chronic constriction injury(CCI)mouse model.The results demonstrated that E0199 significantly inhibited Na_(V)1.7,Na_(V)1.8,and Na_(V)1.9 channels with a particularly low half maximal inhibitory concentration(IC50)for Na_(V)1.9 by promoting sodium channel inactivation,and also effectively increased K_(V)7.2/7.3,K_(V)7.2,and K_(V)7.5 channels,excluding K_(V)7.1 by promoting potassium channel activation.This dual action significantly reduced the excitability of dorsal root ganglion neurons and alleviated pain hypersensitivity in mice at low doses,indicating a potent analgesic effect without affecting heart and skeletal muscle ion channels critically.The safety of E0199 was supported by neurobehavioral evaluations.Conclusively,E0199 represents a ground-breaking approach in NP treatment,showcasing the potential of dual-target small-molecule compounds in providing a more effective and safe therapeutic option for NP.This study introduces a promising direction for the future development of NP therapeutics. 展开更多
关键词 Neuropathic pain Na_(V)channel K_(V)7 channel Dorsal root ganglia
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Confined electric field in nano-sized channels of ionic porous framework towards unique adsorption selectivity
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作者 Congyan Liu Xueyao Zhou +2 位作者 Fei Ye Bin Jiang Bo Liu 《Chinese Chemical Letters》 2025年第2期437-441,共5页
Efficient selective adsorption and separation using porous frameworks are critical in many industrial processes,where adsorption energy and dynamic diffusion rate are predominant factors governing selectivity.They are... Efficient selective adsorption and separation using porous frameworks are critical in many industrial processes,where adsorption energy and dynamic diffusion rate are predominant factors governing selectivity.They are highly susceptible to framework charge,which plays a significant role in selective adsorption.Currently,ionic porous frameworks can be divided into two types.One of them is composed of a charged backbone and counter ions.The framework with zwitterionic channels is another type.It is composed of regular and alternating arrangements of cationic and anionic building units.Herein,we report a hydrogen-bonded ionic framework(HIF)of{(CN_(3)H_(6))_(2)[Ti(μ_(2)-O)(SO_(4))_(2)]}_nwith 1D channel exhibits unique adsorption selectivity for Ar against N_(2)and CO_(2).Density functional theory(DFT)results suggest that CO_(2)cannot be adsorbed by HIF at the experimental temperature due to a positive adsorption free energy.In addition,due to a relatively large diffusion barrier at 77 K,N_(2)molecules hardly diffuse in HIF channels,while Ar has a negligible diffusion barrier.The unique net positively-charged space in the channel is the key to the unusual phenomena,based on DFT simulations and structural analysis.The findings in this work proposes the new adsorption mechanism and provides unique perspective for special separation applications,such as isotope and noble gasses separations. 展开更多
关键词 Adsorption SELECTIVITY channel Positive electric field GUANIDINIUM
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Improving the performance of reference-frame-independent measurement-device-independent quantum key distribution in hybrid channels
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作者 Yan-Mei Zhao Chun Zhou +8 位作者 Xiao-Lei Jiang Yi-Fei Lu Yu Zhou Hai-Tao Wang Yang Wang Jia-Ji Li Yan-Yang Zhou Hong-Wei Li Wan-Su Bao 《Chinese Physics B》 2025年第5期26-32,共7页
The robustness of reference-frame-independent measurement-device-independent quantum key distribution(RFIMDI-QKD)against detection system vulnerabilities and its tolerance to reference frame drifts make it an ideal ch... The robustness of reference-frame-independent measurement-device-independent quantum key distribution(RFIMDI-QKD)against detection system vulnerabilities and its tolerance to reference frame drifts make it an ideal choice for hybrid channels.However,the impact of atmospheric turbulence on transmittance fluctuations remains a significant challenge for enhancing the performance of RFI-MDI-QKD.In this paper,we apply prefixed-threshold real-time selection and advantage distillation techniques to RFI-MDI-QKD in a hybrid channels scenario.Then,we analytically derive formulas for secret key rate in hybrid channels.Simulation results show that our modified scheme has apparent advances in both maximum tolerant loss and secure key rate compared to the fiber-only channel.Specifically,the result demonstrates that the maximum transmission distance can be improved by 15 km and 28 km when N=10^(12)and 10^(11).Our work not only provides a more robust key distribution protocol but also establishes a solid theoretical foundation for enhancing the performance of RFI-MDI-QKD in hybrid channels. 展开更多
关键词 quantum key distribution measurement-device-independent hybrid channels
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Intracellular calcium channels:Potential targets for type 2 diabetes mellitus?
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作者 Jia-Xuan Zhu Zhao-Nan Pan Dan Li 《World Journal of Diabetes》 2025年第4期37-47,共11页
Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosi... Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosis,limits their patient applicability and long-term application.Therefore,it is necessary to screen novel therapeutic drugs for T2DM treatment that have high efficacy but few adverse effects.AMP-activated protein kinase(AMPK)stands out as one of the most powerful targets for T2DM treatment.It can be activated through energysensing or calcium signaling.Medications that activate AMPK through the energy-sensing mechanism exhibit remarkable potency,but they are accompanied by lactic acidosis,carrying an alarmingly high mortality rate.Interestingly,medications that activate AMPK through calcium signaling,such as gliclazide,seldom induce lactic acidosis.However,the efficacy of gliclazide is much lower than metformin.Therefore,it is necessary to explore targets that activate AMPK via calcium signaling to avoid lactic acidosis while maintaining high potency.Ion channels are the main controller of intracellular calcium flow.Specific agonists and inhibitors targeting ion channels have been reported to activate AMPK.In this review,we will summarize the structure and function of calcium-permeable ion channels and discuss the potential of targeting these calcium channels for T2DM treatment. 展开更多
关键词 Ion channels AMP-activated protein kinase CALCIUM DIABETES Lactic acidosis
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XGBoost Based Multiclass NLOS Channels Identification in UWB Indoor Positioning System
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作者 Ammar Fahem Majeed Rashidah Arsat +2 位作者 Muhammad Ariff Baharudin Nurul Mu’azzah Abdul Latiff Abbas Albaidhani 《Computer Systems Science & Engineering》 2025年第1期159-183,共25页
Accurate non-line of sight(NLOS)identification technique in ultra-wideband(UWB)location-based services is critical for applications like drone communication and autonomous navigation.However,current methods using bina... Accurate non-line of sight(NLOS)identification technique in ultra-wideband(UWB)location-based services is critical for applications like drone communication and autonomous navigation.However,current methods using binary classification(LOS/NLOS)oversimplify real-world complexities,with limited generalisation and adaptability to varying indoor environments,thereby reducing the accuracy of positioning.This study proposes an extreme gradient boosting(XGBoost)model to identify multi-class NLOS conditions.We optimise the model using grid search and genetic algorithms.Initially,the grid search approach is used to identify the most favourable values for integer hyperparameters.In order to achieve an optimised model configuration,the genetic algorithm is employed to fine-tune the floating-point hyperparameters.The model evaluations utilise a wide-ranging dataset of real-world measurements obtained with a Qorvo DW1000 UWB device,covering various indoor scenarios.Experimental results show that our proposed XGBoost achieved the highest overall accuracy of 99.47%,precision of 99%,recall of 99%,and an F-score of 99%on an open-source dataset.Additionally,based on a local dataset,the model achieved the highest performance,with an accuracy of 96%,precision of 96%,recall of 97%,and an F-score of 97%.In contrast to current machine learning methods in the literature,the suggestion model enhances classification accuracy and effectively addresses the NLOS/LOS identification as a multiclass propagation channel.This approach provides a robust solution with generalisation and adaptability across various dataset types and environments for more reliable and accurate indoor positioning technologies. 展开更多
关键词 NLOS prediction propagation channels classification optimization indoor localization XGBoost
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Far-Field vs. Near-Field Propagation Channels: Key Differences and Impact on 6G XL-MIMO Performance Evaluation
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作者 Ding Zihang Zhang Jianhua +5 位作者 You Changsheng Tang Pan Xing Hongbo Yuan Zhiqiang Meng Jie Liu Guangyi 《China Communications》 2025年第10期186-198,共13页
Extremely large-scale multiple-input multiple-output(XL-MIMO)is regarded as a promis-ing technology for next-generation communication systems.However,this will expand the near-field(NF)range,rendering more users more ... Extremely large-scale multiple-input multiple-output(XL-MIMO)is regarded as a promis-ing technology for next-generation communication systems.However,this will expand the near-field(NF)range,rendering more users more likely to be located in the NF region.In this paper,we aim to answer two questions:What are the new characteristics of the NF channel?Is it necessary to develop new transciver techniques to maintain system performance within the NF region?To this end,we first review current NF channel models and analyze the differences between the existing 3GPP TR 38.901 channel model and the NF channel model,including the spherical wavefront and spatially non-stationarity.Then,we provide ex-amples on how these differences affect the XL-MIMO system performance in terms of beamforming gain and achievable rate.Simulation results demonstrate that,when using far-field(FF)technique under the NF channel,the maximum normalized beam gain loss is less than 3 dB for most users in the NF region de-fined by Rayleigh distance.Moreover,the achievable rate loss of beam training is less than 3%compared to that realized by NF technique.Finally,we demonstrate the necessity of employing NF transceiver techniques based on simulation results. 展开更多
关键词 channel model near-field communica-tion near-field effect spatial non-stationary
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A sediment influx-outflux-accommodation composite index-based method for estimating sediment storage in debris flow channels
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作者 LEI Xiaohu ZHANG Shaojie +1 位作者 YANG Hongjuan WEI Fangqiang 《Journal of Mountain Science》 2025年第6期1889-1911,共23页
The distribution of the sediment material storage quantity along the debris flow channels(SMSQ_DFC)can provide a foundation for runoffgenerated debris flow prediction or susceptibility assessment.Current models for es... The distribution of the sediment material storage quantity along the debris flow channels(SMSQ_DFC)can provide a foundation for runoffgenerated debris flow prediction or susceptibility assessment.Current models for estimating SMSQ_DFC do not consider the capacity of the channel cross-section to accommodate sediment materials.This accommodation condition serves as a limiting factor in determining whether the expected surplus of sediment materials can ultimately be stored.To address this issue,a mass-conservative index was used to represent the balance of deposit materials at any cross-section,considering the influx from upstream,outflux to downstream,and accommodation capacity.Based on this index,a new model for estimating SMSQ_DFC was developed and subsequently evaluated.The evaluation results show that the model meets the accuracy requirements with average error rates of 14.06%for self-validation and 14.81%for generalization ability validation.To assess its practical applications,the model was applied to the Yeniu Gully in Wenchuan County,Sichuan Province,an area with detailed field survey data.The results show that the model exhibits a commendable performance.Compared to traditional theoretical and semi-theoretical statistical models,our model is easier to use(input parameters can be obtained using Geographic Information Systems(GIS)).The modeling parameters chosen in this study have more theoretical significance than those used in existing purely statistical models,offering more effective technical support for estimating SMSQ_DFC. 展开更多
关键词 Debris flow deposit materials Sediment influx-outflux-accommodation index Sediment materials distribution along channels Deposit materials estimation model channel bed deposits Debris flow provenance materials
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Revenue increased by 370%,new channels for new domestic products:Taihu Snow
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作者 Qiu Shuchen 《China Textile》 2025年第4期40-43,共4页
Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered arou... Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered around the"Taihu Snow"brand,its products cover suite products (such as pillowcases,quilt covers,sheets),quilt cores,silk scarves and otheremerging retail products. 展开更多
关键词 NEW suite products such REVENUE channels domestic emerging retail productsit silk productsthe increase
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