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Multi-focus image fusion with the all convolutional neural network 被引量:3
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作者 杜超本 高社生 《Optoelectronics Letters》 EI 2018年第1期71-75,共5页
A decision map contains complete and clear information about the image to be fused, which is crucial to various image fusion issues, especially multi-focus image fusion. However, in order to get a satisfactory image f... A decision map contains complete and clear information about the image to be fused, which is crucial to various image fusion issues, especially multi-focus image fusion. However, in order to get a satisfactory image fusion effect, getting a decision map is very necessary and usually difficult to finish. In this letter, we address this problem with convolutional neural network(CNN), aiming to get a state-of-the-art decision map. The main idea is that the max-pooling of CNN is replaced by a convolution layer, the residuals are propagated backwards by gradient descent, and the training parameters of the individual layers of the CNN are updated layer by layer. Based on this, we propose a new all CNN(ACNN)-based multi-focus image fusion method in spatial domain. We demonstrate that the decision map obtained from the ACNN is reliable and can lead to high-quality fusion results. Experimental results clearly validate that the proposed algorithm can obtain state-of-the-art fusion performance in terms of both qualitative and quantitative evaluations. 展开更多
关键词 multi-focus image fusion with the all convolutional neural network
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基于UPLC-Orbitrap Fusion Lumos Tribrid-MS的女贞子酒蒸前后血清药物化学对比分析
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作者 刘昊霖 郑历史 +3 位作者 孙淑仃 赵迪 李焕茹 冯素香 《中华中医药学刊》 北大核心 2026年第1期175-186,I0027,共13页
目的基于超高效液相色谱-四极杆-静电场轨道阱-线性离子阱质谱法(ultra performance liquid chromatography-orbitrap fusion lumos tribrid-mass spectrometry,UPLC-Orbitrap Fusion Lumos Tribrid-MS)对大鼠灌胃女贞子、酒女贞子水提... 目的基于超高效液相色谱-四极杆-静电场轨道阱-线性离子阱质谱法(ultra performance liquid chromatography-orbitrap fusion lumos tribrid-mass spectrometry,UPLC-Orbitrap Fusion Lumos Tribrid-MS)对大鼠灌胃女贞子、酒女贞子水提液后血清中的移行成分进行对比分析。方法雄性Sprague-Dawley(SD)大鼠随机分为空白组、女贞子组(10.8 g·kg^(-1)·d^(-1))和酒女贞子组(10.8 g·kg^(-1)·d^(-1)),每组6只,给药组分别灌胃给予女贞子、酒女贞子水提液,空白组灌胃等体积纯净水,早晚各1次,连续5 d,末次给药1 h后腹主动脉取血,制备血清样品。采用Accucore^(TM) C_(18)(100 mm×2.1 mm,2.6μm)色谱柱,流动相为乙腈(A)-0.1%甲酸水(B),梯度洗脱(0~5 min,95%B→85%B;5~10 min,85%B→73%B;10~24 min,73%B→15%B),流速0.2 mL·min^(-1),进样量5μL,正、负离子模式扫描,扫描范围m/z 120~1200。采用Compound Discoverer 3.3软件,根据质谱数据和相关文献对女贞子、酒女贞子入血原型成分和代谢产物进行分析鉴定;采用多元统计分析方法对比女贞子、酒女贞子含药血清间的差异性成分。结果在给予女贞子水提液大鼠血清中共鉴定得到64个入血成分,包括40个原型成分和24个代谢产物;在给予酒女贞子水提液大鼠血清中共鉴定得到57个入血成分,包括35个原型成分和22个代谢产物。原型成分主要包括苯乙醇苷类、环烯醚萜类、三萜类、黄酮类等,代谢途径主要包括羟基化、甲基化、葡萄糖醛酸化等。根据变量重要性投影(variable importance in projection,VIP)值>1,t检验(Student's t test)结果P<0.05筛选出特女贞苷、女贞苷酸等12个差异性入血成分,其中7个原型成分、5个代谢产物。结论女贞子酒蒸后血清移行成分发生明显改变,可为阐明女贞子、酒女贞子药效物质基础提供理论依据。 展开更多
关键词 女贞子 炮制 血清药物化学 UPLC-Orbitrap fusion Lumos Tribrid-MS 多元统计分析
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Multi-Focus Image Fusion Based on Wavelet Transformation 被引量:4
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作者 Peng Zhang Ying-Xun Tang +1 位作者 Yan-Hua Liang Xu-Bo Liu 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2013年第2期124-128,共5页
In the fusion of image,how to measure the local character and clarity is called activity measurement. According to the problem,the traditional measurement is decided only by the high-frequency detail coefficients, whi... In the fusion of image,how to measure the local character and clarity is called activity measurement. According to the problem,the traditional measurement is decided only by the high-frequency detail coefficients, which will make the energy expression insufficient to reflect the local clarity. Therefore,in this paper,a novel construction method for activity measurement is proposed. Firstly,it uses the wavelet decomposition for the fusion resource image, and then utilizes the high and low frequency wavelet coefficients synthetically. Meantime,it takes the normalized variance as the weight of high-frequency energy. Secondly,it calculates the measurement by the weighted energy,which can be used to measure the local character. Finally,the fusion coefficients can be got. In order to illustrate the superiority of this new method,three kinds of assessing indicators are provided. The experiment results show that,comparing with the traditional methods,this new method weakens the fuzzy and promotes the indicator value. Therefore,it has much more advantages for practical application. 展开更多
关键词 variance MEASURE image fusion wavelet transformation multi-resolution analysis
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A New Method of Multi-Focus Image Fusion Using Laplacian Operator and Region Optimization 被引量:1
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作者 Chao Wang Rui Yuan +3 位作者 Yuqiu Sun Yuanxiang Jiang Changsheng Chen Xiangliang Lin 《Journal of Computer and Communications》 2018年第5期106-118,共13页
Considering the continuous advancement in the field of imaging sensor, a host of other new issues have emerged. A major problem is how to find focus areas more accurately for multi-focus image fusion. The multi-focus ... Considering the continuous advancement in the field of imaging sensor, a host of other new issues have emerged. A major problem is how to find focus areas more accurately for multi-focus image fusion. The multi-focus image fusion extracts the focused information from the source images to construct a global in-focus image which includes more information than any of the source images. In this paper, a novel multi-focus image fusion based on Laplacian operator and region optimization is proposed. The evaluation of image saliency based on Laplacian operator can easily distinguish the focus region and out of focus region. And the decision map obtained by Laplacian operator processing has less the residual information than other methods. For getting precise decision map, focus area and edge optimization based on regional connectivity and edge detection have been taken. Finally, the original images are fused through the decision map. Experimental results indicate that the proposed algorithm outperforms the other series of algorithms in terms of both subjective and objective evaluations. 展开更多
关键词 Image fusion LAPLACIAN OPERATOR multi-focus REGION OPTIMIZATION
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Multi-focus image fusion based on block matching in 3D transform domain 被引量:6
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作者 YANG Dongsheng HU Shaohai +2 位作者 LIU Shuaiqi MA Xiaole SUN Yuchao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2018年第2期415-428,共14页
Fusion methods based on multi-scale transforms have become the mainstream of the pixel-level image fusion. However,most of these methods cannot fully exploit spatial domain information of source images, which lead to ... Fusion methods based on multi-scale transforms have become the mainstream of the pixel-level image fusion. However,most of these methods cannot fully exploit spatial domain information of source images, which lead to the degradation of image.This paper presents a fusion framework based on block-matching and 3D(BM3D) multi-scale transform. The algorithm first divides the image into different blocks and groups these 2D image blocks into 3D arrays by their similarity. Then it uses a 3D transform which consists of a 2D multi-scale and a 1D transform to transfer the arrays into transform coefficients, and then the obtained low-and high-coefficients are fused by different fusion rules. The final fused image is obtained from a series of fused 3D image block groups after the inverse transform by using an aggregation process. In the experimental part, we comparatively analyze some existing algorithms and the using of different transforms, e.g. non-subsampled Contourlet transform(NSCT), non-subsampled Shearlet transform(NSST), in the 3D transform step. Experimental results show that the proposed fusion framework can not only improve subjective visual effect, but also obtain better objective evaluation criteria than state-of-the-art methods. 展开更多
关键词 image fusion block matching 3D transform block-matching and 3D(BM3D) non-subsampled Shearlet transform(NSST)
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Efficient Compressive Multi-Focus Image Fusion
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作者 Chao Yang Bin Yang 《Journal of Computer and Communications》 2014年第9期78-86,共9页
Two key points of pixel-level multi-focus image fusion are the clarity measure and the pixel coeffi- cients fusion rule. Along with different improvements on these two points, various fusion schemes have been proposed... Two key points of pixel-level multi-focus image fusion are the clarity measure and the pixel coeffi- cients fusion rule. Along with different improvements on these two points, various fusion schemes have been proposed in literatures. However, the traditional clarity measures are not designed for compressive imaging measurements which are maps of source sense with random or likely ran- dom measurements matrix. This paper presents a novel efficient multi-focus image fusion frame- work for compressive imaging sensor network. Here the clarity measure of the raw compressive measurements is not obtained from the random sampling data itself but from the selected Hada- mard coefficients which can also be acquired from compressive imaging system efficiently. Then, the compressive measurements with different images are fused by selecting fusion rule. Finally, the block-based CS which coupled with iterative projection-based reconstruction is used to re- cover the fused image. Experimental results on common used testing data demonstrate the effectiveness of the proposed method. 展开更多
关键词 CLARITY Measures COMPRESSIVE IMAGING multi-focus IMAGE fusion
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Joint Multi-Focus Fusion and Bayer ImageRestoration
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《信息工程期刊(中英文版)》 2015年第3期67-72,共6页
In this paper, a joint multifocus image fusion and Bayer pattern image restoration algorithm for raw images of single-sensor colorimaging devices is proposed. Different from traditional fusion schemes, the raw Bayer p... In this paper, a joint multifocus image fusion and Bayer pattern image restoration algorithm for raw images of single-sensor colorimaging devices is proposed. Different from traditional fusion schemes, the raw Bayer pattern images are fused before colorrestoration. Therefore, the Bayer image restoration operation is only performed one time. Thus, the proposed algorithm is moreefficient than traditional fusion schemes. In detail, a clarity measurement of Bayer pattern image is defined for raw Bayer patternimages, and the fusion operator is performed on superpixels which provide powerful grouping cues of local image feature. Theraw images are merged with refined weight map to get the fused Bayer pattern image, which is restored by the demosaicingalgorithm to get the full resolution color image. Experimental results demonstrate that the proposed algorithm can obtain betterfused results with more natural appearance and fewer artifacts than the traditional algorithms. 展开更多
关键词 multi-focus IMAGE fusion BAYER PATTERN Superpixel DEMOSAICING
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Effect of Addition of Er-TiB_(2)Dual-Phase Nanoparticles on Strength-Ductility of Al-Mn-Mg-Sc-Zr Alloy Prepared by Laser Powder Bed Fusion
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作者 Li Suli Zhang Yanze +5 位作者 Yang Mengjia Zhang Longbo Xie Qidong Yang Laixia MaoFeng Chen Zhen 《稀有金属材料与工程》 北大核心 2026年第1期9-17,共9页
A dual-phase synergistic enhancement method was adopted to strengthen the Al-Mn-Mg-Sc-Zr alloy fabricated by laser powder bed fusion(LPBF)by leveraging the unique advantages of Er and TiB_(2).Spherical powders of 0.5w... A dual-phase synergistic enhancement method was adopted to strengthen the Al-Mn-Mg-Sc-Zr alloy fabricated by laser powder bed fusion(LPBF)by leveraging the unique advantages of Er and TiB_(2).Spherical powders of 0.5wt%Er-1wt%TiB_(2)/Al-Mn-Mg-Sc-Zr nanocomposite were prepared using vacuum homogenization technique,and the density of samples prepared through the LPBF process reached 99.8%.The strengthening and toughening mechanisms of Er-TiB_(2)were investigated.The results show that Al_(3)Er diffraction peaks are detected by X-ray diffraction analysis,and texture strength decreases according to electron backscatter diffraction results.The added Er and TiB_(2)nano-reinforcing phases act as heterogeneous nucleation sites during the LPBF forming process,hindering grain growth and effectively refining the grains.After incorporating the Er-TiB_(2)dual-phase nano-reinforcing phases,the tensile strength and elongation at break of the LPBF-deposited samples reach 550 MPa and 18.7%,which are 13.4%and 26.4%higher than those of the matrix material,respectively. 展开更多
关键词 Al-Mn-Mg-Sc-Zr alloy laser powder bed fusion nano-reinforcing phase synergistic enhancement
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An Improved Pigeon-Inspired Optimization for Multi-focus Noisy Image Fusion
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作者 Yingda Lyu Yunqi Zhang Haipeng Chen 《Journal of Bionic Engineering》 SCIE EI CSCD 2021年第6期1452-1462,共11页
Image fusion technology is the basis of computer vision task,but information is easily affected by noise during transmission.In this paper,an Improved Pigeon-Inspired Optimization(IPIO)is proposed,and used for multi-f... Image fusion technology is the basis of computer vision task,but information is easily affected by noise during transmission.In this paper,an Improved Pigeon-Inspired Optimization(IPIO)is proposed,and used for multi-focus noisy image fusion by combining with the boundary handling of the convolutional sparse representation.By two-scale image decomposition,the input image is decomposed into base layer and detail layer.For the base layer,IPIO algorithm is used to obtain the optimized weights for fusion,whose value range is gained by fusing the edge information.Besides,the global information entropy is used as the fitness index of the IPIO,which has high efficiency especially for discrete optimization problems.For the detail layer,the fusion of its coefficients is completed by performing boundary processing when solving the convolution sparse representation in the frequency domain.The sum of the above base and detail layers is as the final fused image.Experimental results show that the proposed algorithm has a better fusion effect compared with the recent algorithms. 展开更多
关键词 Improved pigeon-inspired optimization Convolutional sparse representation Noisy image fusion Bionic algorithm
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Bearing Fault Diagnosis Based on Multimodal Fusion GRU and Swin-Transformer
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作者 Yingyong Zou Yu Zhang +2 位作者 Long Li Tao Liu Xingkui Zhang 《Computers, Materials & Continua》 2026年第1期1587-1610,共24页
Fault diagnosis of rolling bearings is crucial for ensuring the stable operation of mechanical equipment and production safety in industrial environments.However,due to the nonlinearity and non-stationarity of collect... Fault diagnosis of rolling bearings is crucial for ensuring the stable operation of mechanical equipment and production safety in industrial environments.However,due to the nonlinearity and non-stationarity of collected vibration signals,single-modal methods struggle to capture fault features fully.This paper proposes a rolling bearing fault diagnosis method based on multi-modal information fusion.The method first employs the Hippopotamus Optimization Algorithm(HO)to optimize the number of modes in Variational Mode Decomposition(VMD)to achieve optimal modal decomposition performance.It combines Convolutional Neural Networks(CNN)and Gated Recurrent Units(GRU)to extract temporal features from one-dimensional time-series signals.Meanwhile,the Markovian Transition Field(MTF)is used to transform one-dimensional signals into two-dimensional images for spatial feature mining.Through visualization techniques,the effectiveness of generated images from different parameter combinations is compared to determine the optimal parameter configuration.A multi-modal network(GSTCN)is constructed by integrating Swin-Transformer and the Convolutional Block Attention Module(CBAM),where the attention module is utilized to enhance fault features.Finally,the fault features extracted from different modalities are deeply fused and fed into a fully connected layer to complete fault classification.Experimental results show that the GSTCN model achieves an average diagnostic accuracy of 99.5%across three datasets,significantly outperforming existing comparison methods.This demonstrates that the proposed model has high diagnostic precision and good generalization ability,providing an efficient and reliable solution for rolling bearing fault diagnosis. 展开更多
关键词 MULTI-MODAL GRU swin-transformer CBAM CNN feature fusion
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Trajectory and influencing factors of changes in anxiety and depression in elderly patients after lumbar interbody fusion
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作者 Xiao-Feng Liu Yan-Hua Wu +4 位作者 Guang-Xi Huang Bin Yu Hui-Juan Xu Meng-Hua Qiu Lin Kang 《World Journal of Psychiatry》 2026年第1期312-321,共10页
BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery... BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery speed and quality of life.Effective prevention of anxiety and depression in elderly patients has become an urgent problem.AIM To investigate the trajectory of anxiety and depression levels in elderly patients after LIF,and the influencing factors.METHODS Random sampling was used to select 239 elderly patients who underwent LIF from January 2020 to December 2024 in Shenzhen Pingle Orthopedic Hospital.General information and surgery-related indices were recorded,and participants completed measures of psychological status,lumbar spine dysfunction,and quality of life.A latent class growth model was used to analyze the post-LIF trajectory of anxiety and depression levels,and unordered multi-categorical logistic regression was used to analyze the influencing factors.RESULTS Three trajectories of change in anxiety level were identified:Increasing anxiety(n=26,10.88%),decreasing anxiety(n=27,11.30%),and stable anxiety(n=186,77.82%).Likewise,three trajectories of change in depression level were identified:Increasing depression(n=30,12.55%),decreasing depression(n=26,10.88%),and stable depression(n=183,76.57%).Regression analysis showed that having no partner,female sex,elevated Oswestry dysfunction index(ODI)scores,and reduced 36-Item Short Form Health Survey scores all contributed to increased anxiety levels,whereas female sex,postoperative opioid use,and elevated ODI scores all contributed to increased depression levels.CONCLUSION During clinical observation,combining factors to predict anxiety and depression in post-LIF elderly patients enables timely intervention,quickens recovery,and enhances quality of life. 展开更多
关键词 Lumbar interbody fusion Elderly patients ANXIETY DEPRESSION Trajectory of change Influencing factors
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Cephalomedullary fusion nails for treatment of infected stemmed revision total knee arthroplasty:Four case reports
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作者 Gregory M Georgiadis Isaac A Arefi +3 位作者 Summer M Drees Ajay Nair Drew Wagner Austin C Lawrence 《World Journal of Orthopedics》 2026年第1期189-196,共8页
BACKGROUND Salvage of the infected long stem revision total knee arthroplasty is challenging due to the presence of well-fixed ingrown or cemented stems.Reconstructive options are limited.Above knee amputation(AKA)is ... BACKGROUND Salvage of the infected long stem revision total knee arthroplasty is challenging due to the presence of well-fixed ingrown or cemented stems.Reconstructive options are limited.Above knee amputation(AKA)is often recommended.We present a surgical technique that was successfully used on four such patients to convert them to a knee fusion(KF)using a cephalomedullary nail.CASE SUMMARY Four patients with infected long stem revision knee replacements that refused AKA had a single stage removal of their infected revision total knee followed by a KF.They were all treated with a statically locked antegrade cephalomedullary fusion nail,augmented with antibiotic impregnated bone cement.All patients had successful limb salvage and were ambulatory with assistive devices at the time of last follow-up.All were infection free at an average follow-up of 25.5 months(range 16-31).CONCLUSION Single stage cephalomedullary nailing can result in a successful KF in patients with infected long stem revision total knees. 展开更多
关键词 Knee fusion Knee arthrodesis Intramedullary nail Cephalomedullary nail Total knee infection Case report
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Identification of small impact craters in Chang’e-4 landing areas using a new multi-scale fusion crater detection algorithm
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作者 FangChao Liu HuiWen Liu +7 位作者 Li Zhang Jian Chen DiJun Guo Bo Li ChangQing Liu ZongCheng Ling Ying-Bo Lu JunSheng Yao 《Earth and Planetary Physics》 2026年第1期92-104,共13页
Impact craters are important for understanding the evolution of lunar geologic and surface erosion rates,among other functions.However,the morphological characteristics of these micro impact craters are not obvious an... Impact craters are important for understanding the evolution of lunar geologic and surface erosion rates,among other functions.However,the morphological characteristics of these micro impact craters are not obvious and they are numerous,resulting in low detection accuracy by deep learning models.Therefore,we proposed a new multi-scale fusion crater detection algorithm(MSF-CDA)based on the YOLO11 to improve the accuracy of lunar impact crater detection,especially for small craters with a diameter of<1 km.Using the images taken by the LROC(Lunar Reconnaissance Orbiter Camera)at the Chang’e-4(CE-4)landing area,we constructed three separate datasets for craters with diameters of 0-70 m,70-140 m,and>140 m.We then trained three submodels separately with these three datasets.Additionally,we designed a slicing-amplifying-slicing strategy to enhance the ability to extract features from small craters.To handle redundant predictions,we proposed a new Non-Maximum Suppression with Area Filtering method to fuse the results in overlapping targets within the multi-scale submodels.Finally,our new MSF-CDA method achieved high detection performance,with the Precision,Recall,and F1 score having values of 0.991,0.987,and 0.989,respectively,perfectly addressing the problems induced by the lesser features and sample imbalance of small craters.Our MSF-CDA can provide strong data support for more in-depth study of the geological evolution of the lunar surface and finer geological age estimations.This strategy can also be used to detect other small objects with lesser features and sample imbalance problems.We detected approximately 500,000 impact craters in an area of approximately 214 km2 around the CE-4 landing area.By statistically analyzing the new data,we updated the distribution function of the number and diameter of impact craters.Finally,we identified the most suitable lighting conditions for detecting impact crater targets by analyzing the effect of different lighting conditions on the detection accuracy. 展开更多
关键词 impact craters Chang’e-4 landing area multi-scale automatic detection YOLO11 fusion algorithm
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Multi-focus Image Fusion Combined with CNN and Algebraic Multi-grid Method
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作者 Ying Huang Gaofeng Mao +1 位作者 Min Liu Yafei Ou 《国际计算机前沿大会会议论文集》 2019年第2期127-129,共3页
The aim of the paper is to solve the problem of over-segmentation problem generated by Watershed segmentation algorithm or unstable clarity judgment by small areas in image fusion. A multi-focus image fusion algorithm... The aim of the paper is to solve the problem of over-segmentation problem generated by Watershed segmentation algorithm or unstable clarity judgment by small areas in image fusion. A multi-focus image fusion algorithm is proposed based on CNN segmentation and algebraic multi-grid method (CNN-AMG). Firstly, the CNN segmentation result was utilized to instruct the merging process of the regions generated by the Watershed segmentation method. Then the clear regions were selected into the temporary fusion image and the final fusion process was performed according to the clarity evaluation index, which was computed with the algebraic multi-grid method (AMG). The experimental results show that the fused image quality obtained by the CNNAMG algorithm outperforms the traditional fusion methods such as DSIFT fusion method, CNN fusion method, ASR fusion method, GFF fusion method and so on with some evaluation indexes. 展开更多
关键词 IMAGE SEGMENTATION IMAGE fusion ALGEBRAIC multi-grid CLARITY Evaluation INDEX
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一种基于Multi-focus+context的鱼眼显示技术 被引量:1
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作者 路强 曹书博 +1 位作者 张广会 朱相元 《系统仿真学报》 CAS CSCD 北大核心 2013年第9期2027-2032,共6页
针对Focus+context中单焦点方式在设备屏幕上只能显示一个焦点的内容细节,而不能对多处关注细节同时显示的局限性,提出一种基于Multi-focus+context技术的,根据关联内容自适应的,显示全局图形及多个焦点内容的细节的方法。焦点区域可以... 针对Focus+context中单焦点方式在设备屏幕上只能显示一个焦点的内容细节,而不能对多处关注细节同时显示的局限性,提出一种基于Multi-focus+context技术的,根据关联内容自适应的,显示全局图形及多个焦点内容的细节的方法。焦点区域可以是任意形状的几何图形,并利用鱼眼功能将这些图形区域放大,非焦点区域大小不变,从而保持屏幕中整个图形的尺寸不变。最后,将这种方法用在移动设备显示地铁地图方面。结果表明,在看清用户关注的多个换乘站细节信息的同时,也能了解到全局的拓扑。 展开更多
关键词 multi-focus+context 鱼眼技术 地铁线路布局 信息可视化
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基于UPLC-Orbitrap Fusion Lumos Tribrid-MS、网络药理学与实验验证的正骨紫金丸活性成分及作用机制研究
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作者 冯志毅 孙淑仃 +3 位作者 郑历史 孙琪 刘泽 冯素香 《中国现代应用药学》 北大核心 2025年第21期3704-3716,共13页
目的基于UPLC-Orbitrap Fusion Lumos Tribrid-MS联合网络药理学与实验验证预测正骨紫金丸活血化瘀的活性成分及其作用机制。方法首先,采用UPLC-Orbitrap Fusion Lumos Tribrid-MS快速表征正骨紫金丸中的化学成分;其次,通过网络药理学... 目的基于UPLC-Orbitrap Fusion Lumos Tribrid-MS联合网络药理学与实验验证预测正骨紫金丸活血化瘀的活性成分及其作用机制。方法首先,采用UPLC-Orbitrap Fusion Lumos Tribrid-MS快速表征正骨紫金丸中的化学成分;其次,通过网络药理学的研究方法构建“药物-成分-靶点”网络,获取关键靶点及主要活性成分,结合String平台与CytoScape软件构建蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络,通过MateScape数据库富集分析通路,利用DiscoVery Studio 4.5软件进行分子对接验证;最后,建立急性软组织损伤动物模型,以急性软组织损伤评分与全血黏度为药效学指标开展药效学研究。结果正骨紫金丸中共鉴定出包括黄酮类、生物碱类、有机酸类和香豆素类等化合物67个,其中大黄素、藁本内酯、肉桂酸、水杨酸、芦荟大黄素可能为正骨紫金丸活血化瘀的主要活性成分。PPI网络拓扑分析得到TNF、ALB、AKT1等26个核心靶点,KEGG富集分析表明正骨紫金丸主要通过调控TNF、PI3K-Akt、NF-κB等信号通路发挥活血化瘀作用,分子对接结果显示正骨紫金丸主要活性成分与关键靶点结合良好,药效学结果表明正骨紫金丸可显著降低急性软组织损伤大鼠的全血黏度。结论本研究明确了正骨紫金丸活血化瘀的活性成分和作用机制,同时表明其可能通过作用于多靶点、多通路整体调节,共同发挥活血化瘀作用,为其后续深入研究提供参考。 展开更多
关键词 正骨紫金丸 UPLC-Orbitrap fusion Lumos Tribrid-MS 成分分析 网络药理学 活血化瘀
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基于Clickteam Fusion的HDB3/AMI编译码实验教学软件设计
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作者 张春光 《电脑编程技巧与维护》 2025年第1期31-34,共4页
论文阐述了一种利用Clickteam Fusion引擎进行HDB3/AMI编译码实验仿真的编程方法。利用计算机技术开发的该仿真实验富有一定的真实感,可直接在计算机上模拟操作。通过学生自主操作,使其掌握光纤实验基本原理,记忆并理解相关操作知识,有... 论文阐述了一种利用Clickteam Fusion引擎进行HDB3/AMI编译码实验仿真的编程方法。利用计算机技术开发的该仿真实验富有一定的真实感,可直接在计算机上模拟操作。通过学生自主操作,使其掌握光纤实验基本原理,记忆并理解相关操作知识,有效提高实验学习效率。 展开更多
关键词 HDB3/AMI编译码实验 仿真 Clickteam fusion引擎
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基于UPLC-Orbitrap Fusion Lumos Tribrid-MS的女贞子不同炮制品血中移行成分分析
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作者 夏仪 孙淑仃 +3 位作者 郑历史 赵迪 李焕茹 冯素香 《中药材》 北大核心 2025年第3期606-615,共10页
目的:研究大鼠灌胃给药醋蒸女贞子、盐蒸女贞子、清蒸女贞子后血清中的移行成分并对其进行对比分析。方法:采用UPLC-Orbitrap Fusion Lumos Tribrid-MS技术,结合Xcalibur和Compound Discoverer软件,根据保留时间、精确分子量、二级碎片... 目的:研究大鼠灌胃给药醋蒸女贞子、盐蒸女贞子、清蒸女贞子后血清中的移行成分并对其进行对比分析。方法:采用UPLC-Orbitrap Fusion Lumos Tribrid-MS技术,结合Xcalibur和Compound Discoverer软件,根据保留时间、精确分子量、二级碎片信息及文献报道,鉴定女贞子不同炮制品的入血成分。基于主成分分析(PCA)和正交偏最小二乘判别分析(OPLS-DA)筛选女贞子不同炮制品含药血清的差异性成分。结果:共鉴定出95个入血成分,其中共有成分89个,醋蒸女贞子特有成分2个、盐蒸女贞子特有成分3个、清蒸女贞子特有成分1个。入血成分包含61个原型成分和34个代谢产物,原型成分主要包括苯乙醇类、环烯醚萜苷类、黄酮类化合物,代谢产物主要涉及羟基化、葡萄糖醛酸化、硫酸酯化反应等。PCA、OPLS-DA结果表明女贞子不同炮制品血中移行成分存在明显差异,OPLS-DA筛选出27个差异性成分。结论:该研究初步阐明了醋蒸女贞子、盐蒸女贞子、清蒸女贞子在大鼠血清中移行成分的差异,为进一步明确女贞子不同炮制品的药效物质基础提供了依据。 展开更多
关键词 女贞子 炮制 血清药物化学 UPLC-Orbitrap fusion Lumos Tribrid-MS 多元统计分析
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Hot Isostatic Pressing for Enhancing Mechanical Properties of Mo Alloys Prepared by Laser Powder Bed Fusion 被引量:1
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作者 Liang Xunwen Fu Zhongxue +3 位作者 Zhang Shiming Che Yusi Cheng Pengming Wang Pei 《稀有金属材料与工程》 北大核心 2025年第3期587-592,共6页
To enhance the mechanical properties of Mo alloys prepared through laser powder bed fusion(LPBF),a hot isostatic pressing(HIP)treatment was used.Results show that following HIP treatment,the porosity decreases from 0.... To enhance the mechanical properties of Mo alloys prepared through laser powder bed fusion(LPBF),a hot isostatic pressing(HIP)treatment was used.Results show that following HIP treatment,the porosity decreases from 0.27%to 0.22%,enabling the elements Mo and Ti to diffuse fully and to distribute more uniformly,and to forming a substantial number of low-angle grain boundaries.The tensile strength soars from 286±32 MPa to 598±22 MPa,while the elongation increases from 0.08%±0.02%to 0.18%±0.02%,without notable alterations in grain morphology during the tensile deformation.HIP treatment eliminates the molten pool boundaries,which are the primary source for premature failure in LPBFed Mo alloys.Consequently,HIP treatment emerges as a novel and effective approach for strengthening the mechanical properties of LPBFed Mo alloys,offering a fresh perspective on producing high-performance Mo-based alloys. 展开更多
关键词 Mo alloys hot isostatic pressing laser powder bed fusion mechanical properties
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TGNet:Intelligent Identification of Thunderstorm Wind Gusts Using Multimodal Fusion 被引量:3
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作者 Xiaowen ZHANG Yongguang ZHENG +3 位作者 Hengde ZHANG Jie SHENG Bingjian LU Shuo FENG 《Advances in Atmospheric Sciences》 2025年第1期146-164,共19页
Thunderstorm wind gusts are small in scale,typically occurring within a range of a few kilometers.It is extremely challenging to monitor and forecast thunderstorm wind gusts using only automatic weather stations.There... Thunderstorm wind gusts are small in scale,typically occurring within a range of a few kilometers.It is extremely challenging to monitor and forecast thunderstorm wind gusts using only automatic weather stations.Therefore,it is necessary to establish thunderstorm wind gust identification techniques based on multisource high-resolution observations.This paper introduces a new algorithm,called thunderstorm wind gust identification network(TGNet).It leverages multimodal feature fusion to fuse the temporal and spatial features of thunderstorm wind gust events.The shapelet transform is first used to extract the temporal features of wind speeds from automatic weather stations,which is aimed at distinguishing thunderstorm wind gusts from those caused by synoptic-scale systems or typhoons.Then,the encoder,structured upon the U-shaped network(U-Net)and incorporating recurrent residual convolutional blocks(R2U-Net),is employed to extract the corresponding spatial convective characteristics of satellite,radar,and lightning observations.Finally,by using the multimodal deep fusion module based on multi-head cross-attention,the temporal features of wind speed at each automatic weather station are incorporated into the spatial features to obtain 10-minutely classification of thunderstorm wind gusts.TGNet products have high accuracy,with a critical success index reaching 0.77.Compared with those of U-Net and R2U-Net,the false alarm rate of TGNet products decreases by 31.28%and 24.15%,respectively.The new algorithm provides grid products of thunderstorm wind gusts with a spatial resolution of 0.01°,updated every 10minutes.The results are finer and more accurate,thereby helping to improve the accuracy of operational warnings for thunderstorm wind gusts. 展开更多
关键词 thunderstorm wind gusts shapelet transform multimodal deep feature fusion
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