As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy o...As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy.展开更多
The multi-energy complementary distributed energy system (MCDES) covers a variety of energy forms, involves complex operation modes, and contains a wealth of control equipment and coupling links. It can realize the co...The multi-energy complementary distributed energy system (MCDES) covers a variety of energy forms, involves complex operation modes, and contains a wealth of control equipment and coupling links. It can realize the complementary and efficient use of different types of energy, which is the basic component of the physical layer of the Energy Internet. In this paper, aiming at the demand of the energy application for towns, a distributed energy system based on multi-energy complementary is constructed. Firstly, the supply condition of the distributed energy for the demonstration project is analyzed, and the architecture of the multi-energy complementary distributed energy system is established. Then the regulation strategy of the multi-energy complementary distributed energy system is proposed. Finally, an overall system scheme for the multi-energy complementary distributed energy system suitable for towns is developed, which provides a solid foundation for the development and promotion of the multi-energy complementary distributed energy system.展开更多
Multi-energy complementary distributed energy system(MECDES)is an important development direction for the energy system.It has the advantages of energy conservation and environmental protection and has great potential...Multi-energy complementary distributed energy system(MECDES)is an important development direction for the energy system.It has the advantages of energy conservation and environmental protection and has great potential to realize efficient energy cascade utilization through the energy conversion and utilization of cooling,heating,and power in place,achieving a user-oriented energy supply.The present study thoroughly reviews the current research status and puts forward the key scientific issues that urgently need to be resolved by investigating the problems and challenges of the MECDES from the perspectives of the characterization of the energetic mass-energy potential,the synergistic transformation and energy-potential coupling mechanism of multi-energy complementation,energy quality improvement and storage,and proactive regulation of the MECDES.Furthermore,the latest research progress of the MECDES for trickling the key scientific issues is comprehensively presented by proposing the distributed energy system with the complementation of multi-energy sources,developing novel ways of the energy potential coupling and energy cascaded comprehensive utilization of multi-energy complementation,proposing a new theory of multi-energy complementation and energy potential coupling and a new mechanism of source complementation,processing matching and thermodynamic cycle system collaborative conversion of both the fossil energy and renewable energy,and developing a new method of proactive adjust and control for adapting to fluctuating energy input and various energy load demands.Finally,the prospects and recommendations for the future research and development direction of MECDES are provided.展开更多
BACKGROUND Complement-mediated thrombotic microangiopathy(TMA)is a rare endothelial injury syndrome caused by dysregulated activation of the alternative complement pathway,often linked to genetic abnormalities in comp...BACKGROUND Complement-mediated thrombotic microangiopathy(TMA)is a rare endothelial injury syndrome caused by dysregulated activation of the alternative complement pathway,often linked to genetic abnormalities in complement factor H(CFH),complement factor I,or complement factor H-related(CFHR)proteins.Both renal transplantation and pregnancy are independent triggers for recurrence.This case highlights a genetically high-risk patient who achieved a successful term pregnancy after renal transplantation without complement inhibition,emphasizing individualized risk stratification,close surveillance,and multidisciplinary management for favourable maternal and graft outcomes.CASE SUMMARY A 32-year-old woman with end-stage renal disease secondary to genetically confirmed complement-mediated TMA—homozygous CFH exon 17 deletion and CFHR3-CFHR1 duplication—was maintained on dialysis for 2.5 years before undergoing a successful live-donor kidney transplant from her mother.Post-transplant immunosuppression included tacrolimus,mycophenolate mofetil,and prednisolone,later modified to azathioprine during pregnancy planning.One-year post-transplant,she conceived spontaneously.Pregnancy was complicated by transient gestational hypertension,controlled with nifedipine,labetalol,and amlodipine.Proteinuria remained<150 mg/day;white blood cell counts 5.8-7.2×109/L without cytopenia.Serum creatinine ranged 0.9-1.1 mg/dL,and tacrolimus trough levels 5-7 ng/mL.At 36 weeks,she delivered a healthy 3 kg infant by elective caesarean section.Postpartum follow-up at three months confirmed stable maternal and graft function.CONCLUSION High-risk complement-mediated TMA patients can achieve successful pregnancy post-transplant through individualized care without mandatory complement blockade.展开更多
With the rapid growth of photovoltaic integration,the volatility and uncertainty of intermittent photovoltaic injection will dramatically reduce system operation reliability from the generation side.The system operato...With the rapid growth of photovoltaic integration,the volatility and uncertainty of intermittent photovoltaic injection will dramatically reduce system operation reliability from the generation side.The system operator may face certain financial risks brought by unexpected power failure under low operation reliability.Therefore,maintaining sufficient power reserve to meet system operation reliability and reduce risk,especially in an isolated system,is essential.However,the traditional reserve preparation strategy fails to consider the uncertainties of the power generation under the high penetration levels of emerging renewable energy resources.A novel reserve preparation strategy for an isolated system is developed in this paper using a twostage model.In the first stage,the optimal hourly scheduling of an isolated system is determined.In the second stage,a minute level conditional value-at-risk(CVaR)based model is established where the uncertainty of the reserve requirement is introduced with the chance constraint.The proposed discretized step transformation(DST)and subtraction type convolution(STC)methods are utilized to convert the model into mixedinteger linear programming,and finally solved by applying the CPLEX solver.The IEEE 39-bus system is used as the test case to validate the feasibility and effectiveness of the proposed two-stage model.展开更多
The multi-energy complementary ecosystem is an important form of the modern energy system.However,standardized evaluation criteria and the corresponding method framework have not yet been formed,resulting in unclear s...The multi-energy complementary ecosystem is an important form of the modern energy system.However,standardized evaluation criteria and the corresponding method framework have not yet been formed,resulting in unclear standards and irregular processes of its construction.To cope with this issue,a novel comprehensive evaluation framework for multi-energy complementary ecosystems is proposed in this study.First,a 5D comprehensive evaluation criteria system,including environment,economy,technology,safety and systematicness,is constructed.Then,a novel multicriteria decision-making model integrating an analytic network process,entropy and preference-ranking organization method for enrichment evaluation under an intuitional fuzzy environment is proposed.Finally,four practical cases are used for model testing and empirical analysis.The results of the research show that the unit cost of the energy supply and the internal rate of return indexes have the highest weights of 0.142 and 0.010,respectively.It means that they are the focus in the construction of a multi-energy complementary ecosystem.The net flows of four cases are 0.015,0.123,-0.132 and-0.005,indicating that cases with a variety of energy supply forms and using intelligent management and control platforms to achieve cold,heat and electrical coupling have more advantages.展开更多
Under the current long-term electricity market mechanism,new energy and thermal power face issues such as deviation assessment and compression of generation space.The profitability of market players is limited.Simulta...Under the current long-term electricity market mechanism,new energy and thermal power face issues such as deviation assessment and compression of generation space.The profitability of market players is limited.Simultaneously,the cooperation model among various energy sources will have a direct impact on the alliance’s revenue and the equity of income distribution within the alliance.Therefore,integrating new energy with thermal power units into an integrated multi-energy complementary system to participate in the long-term electricity market holds significant potential.To simulate and evaluate the benefits and internal distribution methods of a multi-energy complementary system participating in long-term market transactions,this paper first constructs a multi-energy complementary system integrated with new energy and thermal power generation units at the same connection point,and participates in the annual bilateral game as a unified market entity to obtain the revenue value under the annual bilateral market.Secondly,based on the entropy weight method,improvements are made to the traditional Shapley value distribution model,and an internal distribution model for multi-energy complementary systems with multiple participants is constructed.Finally,a Markov Decision Process(MDP)evaluation system is constructed for practical case verification.The research results show that the improved Shapley value distribution model achieves higher satisfaction,providing a reasonable allocation scheme for multi-energy complementary cooperation models.展开更多
In the background of the large-scale development and utilization of renewable energy,the joint operation of a variety of heterogeneous energy sources has become an inevitable development trend.However,the physical cha...In the background of the large-scale development and utilization of renewable energy,the joint operation of a variety of heterogeneous energy sources has become an inevitable development trend.However,the physical characteristics of different power sources and the inherent uncertainties of renewable energy power generation have brought difficulties to the planning,operation and control of power systems.For now,the utilization of multi-energy complementarity to promote energy transformation and improve the consumption of renewable energy has become a common understanding among researchers and the engineering community.This paper makes a review of the research on complementarity of new energy high proportion multi-energy systems from uncertainty modeling,complementary characteristics,planning and operation.We summarize the characteristics of the existing research and provide a reference for the further work.展开更多
Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In ...Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain injury.Our results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and spines.Mice with repetitive traumatic brain injuryalso showed deficits in spatial memory retrieval.Moreover,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was downregulated.An inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological function.These findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.展开更多
To integrate different renewable energy resources effectively in a microgrid, a configuration optimization model of a multi-energy distributed generation（DG） system and its auxiliary equipment is proposed. The model...To integrate different renewable energy resources effectively in a microgrid, a configuration optimization model of a multi-energy distributed generation（DG） system and its auxiliary equipment is proposed. The model mainly consists of two parts, the determination of initial configuration schemes according to user preference and the selection of the optimal scheme. The comprehensive evaluation index（CEI）, which is acquired through the analytic hierarchy process（AHP） weight calculation method, is adopted as the evaluation criterion to rank the initial schemes. The optimal scheme is obtained according to the ranking results. The proposed model takes the diversity of different equipment parameters and investment cost into consideration and can give relatively suitable and economical suggestions for system configuration.Additionally, unlike Homer Pro, the proposed model considers the complementation of different renewable energy resources, and thus the rationality of the multi-energy DG system is improved compared with the single evaluation criterion method which only considers the total cost.展开更多
Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery...Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this population.Following the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing research.In this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the pathology.We study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular patterns.Several effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord injury.Following this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human subjects.This review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.展开更多
The complement system is crucial for maintaining immunological homeostasis in the liver,playing a significant role in both innate and adaptive immune responses.Dysregulation of this system is closely linked to the pat...The complement system is crucial for maintaining immunological homeostasis in the liver,playing a significant role in both innate and adaptive immune responses.Dysregulation of this system is closely linked to the pathogenesis of various liver diseases.Modulating the complement system can affect the progression of these conditions.To provide insights into treating liver injury by targeting the regu-lation of the complement system,we conducted a comprehensive search of major biomedical databases,including MEDLINE,PubMed,EMBASE,and Web of Science,to identify articles on complement and liver injury and reviewed the functions and mechanisms of the complement system in liver injury.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)surveillance is crucial for patients with compensated cirrhosis(CC)and decompensated cirrhosis(DC).Increasing evidence has revealed a connection between thyroid hormone(TH)and H...BACKGROUND Hepatocellular carcinoma(HCC)surveillance is crucial for patients with compensated cirrhosis(CC)and decompensated cirrhosis(DC).Increasing evidence has revealed a connection between thyroid hormone(TH)and HCC,although this relationship remains contentious.Complements and immunoglobulin(Ig),which serve as surrogates of cirrhosis-associated immune dysfunc-tion,are associated with the severity and outcomes of liver cirrhosis(LC).To date,there is a lack of evidence supporting the recommendation of TH,Ig,and com-plement tests in patients at high risk of HCC.AIM To assess the predictive value of TH,Ig,and complements for HCC development.METHODS Data from 142 patients,comprising 72 patients with CC and 70 patients with DC,were analysed as a training set.Among them,100 patients who underwent complement and Ig tests were considered for internal validation.Logistic regression was employed to identify independent risk factors for HCC development.RESULTS The median follow-up duration was 32(24-37 months)months.The incidence of HCC was significantly higher in the DC group(16/70,22.9%)compared to the CC group(3/72,4.2%)(χ^(2)=10.698,P<0.01).Patients with DC exhibited lower total tetraiodothyronine(TT4),total triiodothyronine(TT3),free triiodothyronine,complement C3,and C4(all P<0.01),and higher IgA and IgG(both P<0.01).In both CC and DC patients,TT3 and TT4 positively correlated with alanine transaminase(ALT),aspartate transaminase(AST),and gamma-glutamyl transpeptidase(GGT).IgG positively correlated with IgM,IgA,ALT,and AST,while it negatively correlated with C3 and C4.Multivariable analysis indicated that age,DC status,and GGT were independent risk factors for HCC development.CONCLUSION The predictive value of TH,Ig,and complements for HCC development is suboptimal.Age,DC,and GGT emerge as more significant factors during HCC surveillance in hepatitis B virus-related LC.展开更多
Antibody-mediated rejection(AMR)represents a major challenge in kidney transplantation,significantly contributing to tissue injury and graft failure.AMR is primarily driven by donor-specific alloantibodies(DSAs),which...Antibody-mediated rejection(AMR)represents a major challenge in kidney transplantation,significantly contributing to tissue injury and graft failure.AMR is primarily driven by donor-specific alloantibodies(DSAs),which recognize and bind to specific target antigens present within the transplanted kidney tissue.Upon binding,these DSAs commonly initiate activation of the complement system within the graft.The activation of the complement cascade sets off a powerful inflammatory response characterized by the recruitment and activation of immune cells,endothelial damage,and subsequent tissue injury.This inflammation underlies many clinical and histological manifestations of AMR,making complement activation a critical player in the disease process.Advancements in our understanding of how complement pathways contribute to kidney graft injury have opened new avenues for therapeutic intervention.Recent research has facilitated the development and application of novel therapies specifically designed to inhibit complement activation.Such targeted complement-inhibitory strategies have shown promise in improving graft outcomes by inhibiting complement-mediated damage and extending graft survival.This review comprehensively discusses the critical role of complement activation in inducing kidney graft injury with a focus on its role in AMR.By elucidating the detailed mechanisms and contributions of complement pathways,the review seeks to enhance the understanding necessary for developing targeted therapeutic interventions to prevent or treat AMR effectively.展开更多
We deal with the properties of incompressible and pairwise incompressible surfaces in knot complements through the application of relevant properties of almost simple topological graphs.We analyze the topological grap...We deal with the properties of incompressible and pairwise incompressible surfaces in knot complements through the application of relevant properties of almost simple topological graphs.We analyze the topological graph invariants associated with surfaces embedded in the complements of alternating and almost alternating knots.Specifically,we prove that the characteristic numbers of these graphs remain invariant under two fundamental transformations(R-move and S^(2)-move).Leveraging the interplay between characteristic numbers and Euler characteristics,and further connecting Euler characteristics to surface genus,we derive novel results regarding the genus of incompressible pairwise incompressible surfaces.Additionally,we establish a discriminant criterion to determine when such surfaces in knot complements admit genus zero.展开更多
Technological parameters of asymmetric cast-rolling under multi-energy field were investigated on horizontal twin roll caster（d400 mm×500 mm）, and their effects on structures and properties of 1050 strips were ...Technological parameters of asymmetric cast-rolling under multi-energy field were investigated on horizontal twin roll caster（d400 mm×500 mm）, and their effects on structures and properties of 1050 strips were analyzed by comparing with traditional cast-rolling. Results show that when length of cast-rolling area is 70 mm, melt temperature of head box is 670 °C, cast rolling speed is 1.3 m/min, exciting current is 10 A, center frequency is（13±1） Hz, ultrasonic power is 200 W and ultrasonic frequency is（20±0.2） kHz, the 1050 strip with the best microstructure can be prepared successfully; its center segregated layer disappears; the average grain size is reduced by about 40%; the crystal grains are distributed evenly; micro segregation decreases obviously; the precipitated phases are distributed along the grain boundaries evenly; and the tensile strength, yield strength, elongation and micro-hardness of cast-rolled strip are improved by 22.6%, 23.66%, 38.75% and 9.90%, respectively.展开更多
Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience...Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders.展开更多
基金funded by the National Key R&D Program of China,grant number 2019YFB1505400.
文摘As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy.
文摘The multi-energy complementary distributed energy system (MCDES) covers a variety of energy forms, involves complex operation modes, and contains a wealth of control equipment and coupling links. It can realize the complementary and efficient use of different types of energy, which is the basic component of the physical layer of the Energy Internet. In this paper, aiming at the demand of the energy application for towns, a distributed energy system based on multi-energy complementary is constructed. Firstly, the supply condition of the distributed energy for the demonstration project is analyzed, and the architecture of the multi-energy complementary distributed energy system is established. Then the regulation strategy of the multi-energy complementary distributed energy system is proposed. Finally, an overall system scheme for the multi-energy complementary distributed energy system suitable for towns is developed, which provides a solid foundation for the development and promotion of the multi-energy complementary distributed energy system.
基金supported by the Major Program of the National Natural Science Foundation of China(Grant No.52090060)。
文摘Multi-energy complementary distributed energy system(MECDES)is an important development direction for the energy system.It has the advantages of energy conservation and environmental protection and has great potential to realize efficient energy cascade utilization through the energy conversion and utilization of cooling,heating,and power in place,achieving a user-oriented energy supply.The present study thoroughly reviews the current research status and puts forward the key scientific issues that urgently need to be resolved by investigating the problems and challenges of the MECDES from the perspectives of the characterization of the energetic mass-energy potential,the synergistic transformation and energy-potential coupling mechanism of multi-energy complementation,energy quality improvement and storage,and proactive regulation of the MECDES.Furthermore,the latest research progress of the MECDES for trickling the key scientific issues is comprehensively presented by proposing the distributed energy system with the complementation of multi-energy sources,developing novel ways of the energy potential coupling and energy cascaded comprehensive utilization of multi-energy complementation,proposing a new theory of multi-energy complementation and energy potential coupling and a new mechanism of source complementation,processing matching and thermodynamic cycle system collaborative conversion of both the fossil energy and renewable energy,and developing a new method of proactive adjust and control for adapting to fluctuating energy input and various energy load demands.Finally,the prospects and recommendations for the future research and development direction of MECDES are provided.
文摘BACKGROUND Complement-mediated thrombotic microangiopathy(TMA)is a rare endothelial injury syndrome caused by dysregulated activation of the alternative complement pathway,often linked to genetic abnormalities in complement factor H(CFH),complement factor I,or complement factor H-related(CFHR)proteins.Both renal transplantation and pregnancy are independent triggers for recurrence.This case highlights a genetically high-risk patient who achieved a successful term pregnancy after renal transplantation without complement inhibition,emphasizing individualized risk stratification,close surveillance,and multidisciplinary management for favourable maternal and graft outcomes.CASE SUMMARY A 32-year-old woman with end-stage renal disease secondary to genetically confirmed complement-mediated TMA—homozygous CFH exon 17 deletion and CFHR3-CFHR1 duplication—was maintained on dialysis for 2.5 years before undergoing a successful live-donor kidney transplant from her mother.Post-transplant immunosuppression included tacrolimus,mycophenolate mofetil,and prednisolone,later modified to azathioprine during pregnancy planning.One-year post-transplant,she conceived spontaneously.Pregnancy was complicated by transient gestational hypertension,controlled with nifedipine,labetalol,and amlodipine.Proteinuria remained<150 mg/day;white blood cell counts 5.8-7.2×109/L without cytopenia.Serum creatinine ranged 0.9-1.1 mg/dL,and tacrolimus trough levels 5-7 ng/mL.At 36 weeks,she delivered a healthy 3 kg infant by elective caesarean section.Postpartum follow-up at three months confirmed stable maternal and graft function.CONCLUSION High-risk complement-mediated TMA patients can achieve successful pregnancy post-transplant through individualized care without mandatory complement blockade.
文摘With the rapid growth of photovoltaic integration,the volatility and uncertainty of intermittent photovoltaic injection will dramatically reduce system operation reliability from the generation side.The system operator may face certain financial risks brought by unexpected power failure under low operation reliability.Therefore,maintaining sufficient power reserve to meet system operation reliability and reduce risk,especially in an isolated system,is essential.However,the traditional reserve preparation strategy fails to consider the uncertainties of the power generation under the high penetration levels of emerging renewable energy resources.A novel reserve preparation strategy for an isolated system is developed in this paper using a twostage model.In the first stage,the optimal hourly scheduling of an isolated system is determined.In the second stage,a minute level conditional value-at-risk(CVaR)based model is established where the uncertainty of the reserve requirement is introduced with the chance constraint.The proposed discretized step transformation(DST)and subtraction type convolution(STC)methods are utilized to convert the model into mixedinteger linear programming,and finally solved by applying the CPLEX solver.The IEEE 39-bus system is used as the test case to validate the feasibility and effectiveness of the proposed two-stage model.
基金supported by the second batch of the soft subject research project of China Southern Power Grid Corporation in 2022,‘Exploring the construction path of multi energy complementary ecosystem of industrial parks in Qianhai’(XNXM_20221209003).
文摘The multi-energy complementary ecosystem is an important form of the modern energy system.However,standardized evaluation criteria and the corresponding method framework have not yet been formed,resulting in unclear standards and irregular processes of its construction.To cope with this issue,a novel comprehensive evaluation framework for multi-energy complementary ecosystems is proposed in this study.First,a 5D comprehensive evaluation criteria system,including environment,economy,technology,safety and systematicness,is constructed.Then,a novel multicriteria decision-making model integrating an analytic network process,entropy and preference-ranking organization method for enrichment evaluation under an intuitional fuzzy environment is proposed.Finally,four practical cases are used for model testing and empirical analysis.The results of the research show that the unit cost of the energy supply and the internal rate of return indexes have the highest weights of 0.142 and 0.010,respectively.It means that they are the focus in the construction of a multi-energy complementary ecosystem.The net flows of four cases are 0.015,0.123,-0.132 and-0.005,indicating that cases with a variety of energy supply forms and using intelligent management and control platforms to achieve cold,heat and electrical coupling have more advantages.
文摘Under the current long-term electricity market mechanism,new energy and thermal power face issues such as deviation assessment and compression of generation space.The profitability of market players is limited.Simultaneously,the cooperation model among various energy sources will have a direct impact on the alliance’s revenue and the equity of income distribution within the alliance.Therefore,integrating new energy with thermal power units into an integrated multi-energy complementary system to participate in the long-term electricity market holds significant potential.To simulate and evaluate the benefits and internal distribution methods of a multi-energy complementary system participating in long-term market transactions,this paper first constructs a multi-energy complementary system integrated with new energy and thermal power generation units at the same connection point,and participates in the annual bilateral game as a unified market entity to obtain the revenue value under the annual bilateral market.Secondly,based on the entropy weight method,improvements are made to the traditional Shapley value distribution model,and an internal distribution model for multi-energy complementary systems with multiple participants is constructed.Finally,a Markov Decision Process(MDP)evaluation system is constructed for practical case verification.The research results show that the improved Shapley value distribution model achieves higher satisfaction,providing a reasonable allocation scheme for multi-energy complementary cooperation models.
基金supported by the Science and Technology Project of State Grid Corporation of China.
文摘In the background of the large-scale development and utilization of renewable energy,the joint operation of a variety of heterogeneous energy sources has become an inevitable development trend.However,the physical characteristics of different power sources and the inherent uncertainties of renewable energy power generation have brought difficulties to the planning,operation and control of power systems.For now,the utilization of multi-energy complementarity to promote energy transformation and improve the consumption of renewable energy has become a common understanding among researchers and the engineering community.This paper makes a review of the research on complementarity of new energy high proportion multi-energy systems from uncertainty modeling,complementary characteristics,planning and operation.We summarize the characteristics of the existing research and provide a reference for the further work.
基金supported by the Fundamental Research Program of Shanxi Province of China,No.20210302124277the Science Foundation of Shanxi Bethune Hospital,No.2021YJ13(both to JW)。
文摘Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain injury.Our results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and spines.Mice with repetitive traumatic brain injuryalso showed deficits in spatial memory retrieval.Moreover,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was downregulated.An inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological function.These findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.
基金The National Natural Science Foundation of China(No.51377021)the Science and Technology Project of State Grid Corporation of China(No.SGTJDK00DWJS1600014)
文摘To integrate different renewable energy resources effectively in a microgrid, a configuration optimization model of a multi-energy distributed generation（DG） system and its auxiliary equipment is proposed. The model mainly consists of two parts, the determination of initial configuration schemes according to user preference and the selection of the optimal scheme. The comprehensive evaluation index（CEI）, which is acquired through the analytic hierarchy process（AHP） weight calculation method, is adopted as the evaluation criterion to rank the initial schemes. The optimal scheme is obtained according to the ranking results. The proposed model takes the diversity of different equipment parameters and investment cost into consideration and can give relatively suitable and economical suggestions for system configuration.Additionally, unlike Homer Pro, the proposed model considers the complementation of different renewable energy resources, and thus the rationality of the multi-energy DG system is improved compared with the single evaluation criterion method which only considers the total cost.
基金supported by the Department of Veterans Affairs(VA Merit Award BX004256)(to AMA)Emory Department of Neurosurgery Catalyst GrantEmory Medical Care Foundation Grant(to AMA and JG)。
文摘Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this population.Following the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing research.In this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the pathology.We study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular patterns.Several effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord injury.Following this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human subjects.This review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.
基金Supported by the Science and Technology Planning Projects of Guizhou Province,No.QKHJC-ZK[2022]YB642the Science and Technology Planning Projects of Zunyi City,No.ZSKHHZ(2022)344+4 种基金the WBE Liver Fibrosis Foundation,No.CFHPC2025028the Chinese Foundation for Hepatitis Prevention and Control Muxin Research Fund of CHB,No.MX202404Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-Rgg018the Graduate Research Fund Project of Zunyi Medical University,No.ZYK246the Student Innovation and Entrepreneurship Training Program of Zunyi Medical University,No.2024106610923 and No.S202310661028.
文摘The complement system is crucial for maintaining immunological homeostasis in the liver,playing a significant role in both innate and adaptive immune responses.Dysregulation of this system is closely linked to the pathogenesis of various liver diseases.Modulating the complement system can affect the progression of these conditions.To provide insights into treating liver injury by targeting the regu-lation of the complement system,we conducted a comprehensive search of major biomedical databases,including MEDLINE,PubMed,EMBASE,and Web of Science,to identify articles on complement and liver injury and reviewed the functions and mechanisms of the complement system in liver injury.
基金Supported by The Research Foundation of Jiangsu Province Administration of Traditional Chinese Medicine,No.MS2023088The Science and Technology Project of Changzhou,No.CE20225040+1 种基金The Research Foundation of Nanjing Medical University Changzhou Medical Center,No.CMCC202311Leading Talent of Changzhou“The 14th Five-Year Plan”High-Level Health Talents Training Project,No.2022CZLJ021.
文摘BACKGROUND Hepatocellular carcinoma(HCC)surveillance is crucial for patients with compensated cirrhosis(CC)and decompensated cirrhosis(DC).Increasing evidence has revealed a connection between thyroid hormone(TH)and HCC,although this relationship remains contentious.Complements and immunoglobulin(Ig),which serve as surrogates of cirrhosis-associated immune dysfunc-tion,are associated with the severity and outcomes of liver cirrhosis(LC).To date,there is a lack of evidence supporting the recommendation of TH,Ig,and com-plement tests in patients at high risk of HCC.AIM To assess the predictive value of TH,Ig,and complements for HCC development.METHODS Data from 142 patients,comprising 72 patients with CC and 70 patients with DC,were analysed as a training set.Among them,100 patients who underwent complement and Ig tests were considered for internal validation.Logistic regression was employed to identify independent risk factors for HCC development.RESULTS The median follow-up duration was 32(24-37 months)months.The incidence of HCC was significantly higher in the DC group(16/70,22.9%)compared to the CC group(3/72,4.2%)(χ^(2)=10.698,P<0.01).Patients with DC exhibited lower total tetraiodothyronine(TT4),total triiodothyronine(TT3),free triiodothyronine,complement C3,and C4(all P<0.01),and higher IgA and IgG(both P<0.01).In both CC and DC patients,TT3 and TT4 positively correlated with alanine transaminase(ALT),aspartate transaminase(AST),and gamma-glutamyl transpeptidase(GGT).IgG positively correlated with IgM,IgA,ALT,and AST,while it negatively correlated with C3 and C4.Multivariable analysis indicated that age,DC status,and GGT were independent risk factors for HCC development.CONCLUSION The predictive value of TH,Ig,and complements for HCC development is suboptimal.Age,DC,and GGT emerge as more significant factors during HCC surveillance in hepatitis B virus-related LC.
文摘Antibody-mediated rejection(AMR)represents a major challenge in kidney transplantation,significantly contributing to tissue injury and graft failure.AMR is primarily driven by donor-specific alloantibodies(DSAs),which recognize and bind to specific target antigens present within the transplanted kidney tissue.Upon binding,these DSAs commonly initiate activation of the complement system within the graft.The activation of the complement cascade sets off a powerful inflammatory response characterized by the recruitment and activation of immune cells,endothelial damage,and subsequent tissue injury.This inflammation underlies many clinical and histological manifestations of AMR,making complement activation a critical player in the disease process.Advancements in our understanding of how complement pathways contribute to kidney graft injury have opened new avenues for therapeutic intervention.Recent research has facilitated the development and application of novel therapies specifically designed to inhibit complement activation.Such targeted complement-inhibitory strategies have shown promise in improving graft outcomes by inhibiting complement-mediated damage and extending graft survival.This review comprehensively discusses the critical role of complement activation in inducing kidney graft injury with a focus on its role in AMR.By elucidating the detailed mechanisms and contributions of complement pathways,the review seeks to enhance the understanding necessary for developing targeted therapeutic interventions to prevent or treat AMR effectively.
基金Supported by the National Natural Science Foundation of China(Grant No.12026411)。
文摘We deal with the properties of incompressible and pairwise incompressible surfaces in knot complements through the application of relevant properties of almost simple topological graphs.We analyze the topological graph invariants associated with surfaces embedded in the complements of alternating and almost alternating knots.Specifically,we prove that the characteristic numbers of these graphs remain invariant under two fundamental transformations(R-move and S^(2)-move).Leveraging the interplay between characteristic numbers and Euler characteristics,and further connecting Euler characteristics to surface genus,we derive novel results regarding the genus of incompressible pairwise incompressible surfaces.Additionally,we establish a discriminant criterion to determine when such surfaces in knot complements admit genus zero.
基金Project(2014CB046702)supported by National Basic Research Program of China
文摘Technological parameters of asymmetric cast-rolling under multi-energy field were investigated on horizontal twin roll caster（d400 mm×500 mm）, and their effects on structures and properties of 1050 strips were analyzed by comparing with traditional cast-rolling. Results show that when length of cast-rolling area is 70 mm, melt temperature of head box is 670 °C, cast rolling speed is 1.3 m/min, exciting current is 10 A, center frequency is（13±1） Hz, ultrasonic power is 200 W and ultrasonic frequency is（20±0.2） kHz, the 1050 strip with the best microstructure can be prepared successfully; its center segregated layer disappears; the average grain size is reduced by about 40%; the crystal grains are distributed evenly; micro segregation decreases obviously; the precipitated phases are distributed along the grain boundaries evenly; and the tensile strength, yield strength, elongation and micro-hardness of cast-rolled strip are improved by 22.6%, 23.66%, 38.75% and 9.90%, respectively.
基金supported by the National Natural Science Foundation of China,No.31760290,82160688the Key Development Areas Project of Ganzhou Science and Technology,No.2022B-SF9554(all to XL)。
文摘Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders.
