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Numerical simulation research on multi-electrodes resistivity imaging survey array
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作者 Jianjun NIU Xiaopei ZHANG Lizhi DU 《Global Geology》 2008年第4期232-236,共5页
Multi-electrodes Resistivity Imaging Survey(MRIS)is an array method of electrical survey.In practice how to choose a reasonable array is the key to get reliable survey results.Based on four methods of MRIS such as Wen... Multi-electrodes Resistivity Imaging Survey(MRIS)is an array method of electrical survey.In practice how to choose a reasonable array is the key to get reliable survey results.Based on four methods of MRIS such as Wenner,Schlumberger,Pole-pole and Dipole-dipole the authors established the model,by studying the result of the forward numerical simulation modeling and inverse modeling,and analyzed the differences among the different forms of detection devices. 展开更多
关键词 multi-electrodes resistivity imaging surveys forward model ARRAY
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CNN-ALSTM Soft-Sensing Model for Resistivity Gradient in CZ Monocrystalline Silicon Wafers 被引量:1
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作者 Zhiheng Zhang Zengguo Tian 《Instrumentation》 2025年第2期71-79,共9页
This study addresses the challenge of real-time resistivity gradient measurement in the Czochralski(CZ)silicon production process.Due to the inability to directly measure this parameter,we propose a Long Short-Term Me... This study addresses the challenge of real-time resistivity gradient measurement in the Czochralski(CZ)silicon production process.Due to the inability to directly measure this parameter,we propose a Long Short-Term Memory soft-sensing model based on Convolutional Neural Network(CNN)and attention mechanism(CNN-ALSTM)that enhances traditional LSTM by integrating CNN and attention mechanism to overcome time lag variations during silicon pulling.The CNN module extracts spatial features from multi-source sensor data,while the attention-enhanced LSTM(ALSTM)dynamically adjusts historical parameter weights,enabling accurate resistivity gradient prediction.Experiments with real production data show that CNN-ALSTM outperforms SVR,FNN,RNN,XGBoost,and GRU,improving prediction accuracy by 11.76%,16.67%,21.05%,30.23%,and 9.09%,respectively.This soft-sensing approach enhances real-time monitoring and optimization of monocrystalline silicon growth. 展开更多
关键词 CZ monocrystalline silicon soft-sensing model CNN-ALSTM resistivity gradient
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Reducing specific contact resistivity of V/Al/Ti/Au n-electrode on n-AlGaN with Al content over 80%for far-UVC LEDs
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作者 Jiale Peng Ke Jiang +8 位作者 Shanli Zhang Jianwei Ben Kexi Liu Ziyue Qin Ruihua Chen Chunyue Zhang Shunpeng Lv Xiaojuan Sun Dabing Li 《Journal of Semiconductors》 2025年第9期42-49,共8页
AlGaN-based LEDs with peak wavelength below 240 nm(far-UVC)pose no significant harm to human health,thus highlighting their broader application potential.While,there is a significant Schottky barrier between the n-ele... AlGaN-based LEDs with peak wavelength below 240 nm(far-UVC)pose no significant harm to human health,thus highlighting their broader application potential.While,there is a significant Schottky barrier between the n-electrode and Alrich n-AlGaN,adversely impeding electron injection and resulting in considerable heat generation.Here,we fabricate V-based electrodes of V/Al/Ti/Au on n-AlGaN with Al content over 80%and investigate the relationship between the metal diffusion and contact properties during the high-temperature annealing process.Experiments reveal that decreasing V thickness in the electrode promotes the diffusion of Al towards the surface of n-AlGaN,which facilitates the formation of VN and thus the increase of local electron concentration,resulting in lower specific contact resistivity.Then,increasing the Al thickness inhibits the diffusion of Au to the n-AlGaN surface,suppressing the rise of Schottky barrier.Experimentally,an optimized n-electrode of V(10 nm)/Al(240 nm)/Ti(40 nm)/Au(50 nm)on n-Al_(0.81)Ga_(0.19)N is obtained,realizing an optimal specific contact resistivity of 7.30×10^(−4)Ω·cm^(2).Based on the optimal n-electrode preparation scheme for Al-rich n-AlGaN,the work voltage of a far-UVC LED with peak wavelength of 233.5 nm is effectively reduced. 展开更多
关键词 Al-rich n-AlGaN specific contact resistivity far-UVC LED
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Evaluation of electrical resistivity of lead-contaminated soils stabilized by electrolytic manganese residue-based binder
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作者 Chaoliu Tu Yuan Li +2 位作者 Chen Wang Lei Liu Yi Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第10期6621-6635,共15页
Evaluating the stabilized lead(Pb)-contaminated soils through sampling and laboratory testing involves costly and time-consuming processes.Therefore,this study employed a low-cost and non-destructive resistivity tool ... Evaluating the stabilized lead(Pb)-contaminated soils through sampling and laboratory testing involves costly and time-consuming processes.Therefore,this study employed a low-cost and non-destructive resistivity tool to evaluate the Pb-contaminated soils stabilized by electrolytic manganese residue(EMR)-based geopolymer(EG-OPC)from the strength and environmental benefits perspective.First,unconfined compressive strength(UCS)and leaching tests were conducted to study the stabilization effectiveness of EG-OPC.Results indicated that the UCS values of soil(5000 mg/kg of pollutants)stabilized by 20%EG-OPC were 4.87 MPa and 8.13 MPa after 7 d and 60 d of curing,respectively.After 60 d of curing,the Pb concentration in the leachate reached 44 mg/L,far lower than the control group(321 mg/L).Second,soil,pore water,and leachate resistivity(ERS,ERW,and ERL)were measured to establish fitting relationships with strength parameters and pollution risk.The good fitting results(e.g.ERS/ERW versus UCS/secant modulus(E50):correlation coefficient R2 z 0.9,ERS/ERW versus Pb contents:R2 z 0.9,and ERL versus Pb2þconcentration:R2¼0.92)and well used Archie's law(ERS versus ERW:R2>0.9)indicate that the resistivity can be used to evaluate the stabilization effectiveness.Furthermore,the microscopic results revealed two behaviors,demonstrating the reliability of resistivity:(1)with the hydration process,resistivity increases due to a denser structure and lower amounts of free water and Pb ions,and(2)the addition of Pb reduces resistivity due to its inhibition or even destructive effects on cementation and formation of hydration products. 展开更多
关键词 Stabilization effectiveness resistivity Lead leaching Stabilization mechanism Soil structure
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Experimental Analysis of Resistivity Logging Response of Marine Gas Hydrate Reservoirs
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作者 CHEN Qiang LI Chengfeng +5 位作者 WANG Hongbin LIU Changling BU Qingtao SUN Jianye WEI Jiangong KOU Beibei 《Journal of Ocean University of China》 2025年第1期85-94,共10页
Natural gas hydrates are widely distributed in marine and permafrost environments.As a novel energy resource,accurately describing reservoir characteristics and assessing energy potential is crucial for its commercial... Natural gas hydrates are widely distributed in marine and permafrost environments.As a novel energy resource,accurately describing reservoir characteristics and assessing energy potential is crucial for its commercial development.Resistivity logging serves as a valuable approach for achieving these goals.Nevertheless,due to inadequate comprehension of the electrical conductivity mechanism in hydrate-bearing sediments,existing data processing models still encounter certain challenges.This study conducts both core-scale and pore-scale simulation experiments to examine the relationship between resistivity variations and the distribution of gas hydrate porosity.The results indicate that the characteristics of resistivity variation is associated with the gas hydrate formation process,and the gas hydrate saturation index,denoted as‘n',varies between 0 and 3 depending on different gas hydrate distribution patterns.As the saturation increases,gas hydrate distribution in pore spaces transitions from floating to contacting and cementing patterns.It is proposed that the aqueous pore tortuosity can be utilized to correct the saturation index‘n'in Archie's equation.Based on the analysis of experimental data,a correction method for Archie's equation is suggested,and its effectiveness in controlling relative error has been validated. 展开更多
关键词 gas hydrate electrical resistivity Archie's equation pore connectivity micro distribution
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Calculating Sound Absorption Coefficients of Sound-Absorbing Materials Using Flow Resistivity
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作者 ZHU Congyun SHAO Zhenya DING Guofang 《Journal of Donghua University(English Edition)》 2025年第2期197-203,共7页
To minimize the calculation errors in the sound absorption coefficient resulting from inaccurate measurements of flow resistivity,a simple method for determining the sound absorption coefficient of soundabsorbing mate... To minimize the calculation errors in the sound absorption coefficient resulting from inaccurate measurements of flow resistivity,a simple method for determining the sound absorption coefficient of soundabsorbing materials is proposed.Firstly,the sound absorption coefficients of a fibrous sound-absorbing material are measured at two different frequencies using the impedance tube method.Secondly,utilizing the empirical formulas for the wavenumber and acoustic impedance in the fibrous material,the flow resistivity and porosity of the sound-absorbing materials are calculated using the MATLAB cycle program.Thirdly,based on the values obtained through reverse calculations,the sound absorption coefficient,the real and the imaginary parts of the acoustic impedance of the sound-absorbing material at different frequencies are theoretically computed.Finally,the accuracy of these theoretical calculations is verified through experiments.The experimental results indicate that the calculated values are basically consistent with the measured values,demonstrating the feasibility and reliability of this method. 展开更多
关键词 sound-absorbing material sound absorption coefficient flow resistivity acoustic impedance
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Shear characteristics and damage mechanism of carbonaceous mudstone soil-rock mixed fillers based on electrical resistivity
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作者 ZENG Ling TANG Jing +2 位作者 ZHANG Saize TANG Jing CHEN Jingcheng 《Journal of Mountain Science》 2025年第12期4737-4752,共16页
With carbonaceous mudstone increasingly employed as fill material for road embankments in areas of China such as Guangxi and Hunan,its longterm stability has become a significant engineering concern.This study adopted... With carbonaceous mudstone increasingly employed as fill material for road embankments in areas of China such as Guangxi and Hunan,its longterm stability has become a significant engineering concern.This study adopted a test method combining direct shear and resistivity measurements.The dynamic coupling mechanism of the mechanical properties and resistivity response of carbonaceous mudstone soil-rock mixed fillers during the shear process was systematically investigated by controlling the influencing factors of rock content and normal stress.The study indicates that the filler's shear failure mode gradually shifts from strain softening to plastic flow as the rock content increases,with shear strength and strength parameters exhibiting an initial increase followed by a subsequent decrease.When the rock content exceeds 60%,particle breakage is markedly intensified,and an increase in normal stress further facilitates the breakdown of coarse particles.The resistivity of the specimen demonstrates a strong positive correlation with shear displacement.The initial resistivity exhibits a rising trend with increasing rock content,and variations in rock content notably impact the resistivity's extreme differenceΔρ(Ω·m).60%rock content is the key critical point of the shear strength,Br,andΔρof the packing.At this point,the shear strength reaches the maximum value,the Br value undergoes a transition,andΔρis the lowest.In this study,the variation of resistivity is utilized to characterize the evolution law of internal structural damage during the shear process,with the aim of providing a theoretical basis for the long-term stability analysis of carbonaceous mudstone soil-rock mixed fill embankments. 展开更多
关键词 Carbonaceous mudstone Shear properties Electrical resistivity Particle breakage Damage evolution
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Application of high-density electrical resistivity tomography in backfilling effectiveness of quarries:A case study of Liuyao Village quarry in Huaibei City,Anhui Province
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作者 XU Guangrui LIU Lijia HAN Jiangtao 《Global Geology》 2025年第4期231-239,共9页
Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfil... Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfill soil,predominantly composed of silty clay,demonstrates high water retention capacity and elevated moisture content,leading to a pronounced resistivity contrast with the bedrock exposed by quarrying activities.To investigate the distribution of backfill soil subsurface and assess backfilling effectiveness in the study area,this study conducted a comprehensive geophysical investigation utilizing the high-density electrical resistivity tomography(ERT).A total of 19 ERT survey lines were deployed across three distinct areas in Liuyao Village,Huaibei City,Anhui Province,China.The inversion results,derived from both two-dimensional(2D)and three-dimensional(3D),reveal distinct electrical properties of the subsurface materials:the backfill soil layer shows low resistivity features,the fill stone layer exhibits medium to high resistivity,and the bedrock shows the highest resistivity.The 2D inversion results,from the data measured using the Wenner array effectively capture the spatial distribution and structural features of the backfill soil layer.The findings indicate a gradual east-west thinning of the clay layer within the quarry.Furthermore,the northern pit area exhibits a uniform distribution of backfill soil layer,indicative of effective backfilling operations.In contrast,the southern pit area lacks a well-defined clay layer,suggesting suboptimal backfilling effectiveness. 展开更多
关键词 high-density electrical resistivity tomography Wenner array backfilling effectiveness backfill soil
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Fast Forward Modeling of Resistivity Method under Complex Topography Using Finite Element Method
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作者 Wang Zhan Li Chang-Wei +3 位作者 Lv Yu-Zeng Luo Run-Lin Cheng Bo Li Bo 《Applied Geophysics》 2025年第4期1271-1283,1498,共14页
A parallel finite element scheme for 3D resistivity method forward modeling is introduced in this article.The domain decomposition algorithm,along with a message passing interface,is used to implement parallelism.The ... A parallel finite element scheme for 3D resistivity method forward modeling is introduced in this article.The domain decomposition algorithm,along with a message passing interface,is used to implement parallelism.The computational domain is divided into subdomains,and mesh partitioning is combined with load balancing.Unstructured meshes and local mesh refinement strategies are used to realize high precision for complex topography models.Furthermore,an improved linear solver for multi-electrode resistivity method modeling is adopted.Recycling preconditioned conjugate gradient,which is a linear solver,is based on the similarity of linear systems between point sources.The multiple right-hand-side linear systems corresponding to different point source positions are constructed,and the accelerated convergence is obtained through recycling subspace using the linear solver.The computational accuracy and efficiency of the forward scheme for complex topography models are verified using the numerical test results. 展开更多
关键词 resistivity method parallel computing multiple linear systems recycling Krylov subspace
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Mechanism and Application of Dynamic Monitoring for Seepage Processes in Earth-Rock Dams Using the Time-Lapse Electrical Resistivity Method
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作者 Cai Zu-gen Yang Ming-sheng +1 位作者 Wang Jian-jun Xu Yao-hui 《Applied Geophysics》 2025年第4期1464-1474,1502,共12页
In the leakage detection of reservoir dam bodies,traditional geophysical methods can only achieve one-time detection.Meanwhile,due to the non-uniqueness of geophysicalin version,how to improve the fidelity of geophysi... In the leakage detection of reservoir dam bodies,traditional geophysical methods can only achieve one-time detection.Meanwhile,due to the non-uniqueness of geophysicalin version,how to improve the fidelity of geophysical detection inversion profiles has become a key challenge in the industry.This study aims to construct a long-term real-time monitoring system using the time-lapse resistivity method,reveal the spatiotemporal evolution law of dam leakage,and provide technical support for accurate treatment.By integrating the Internet of Things(IoT),5G technology,and AI technology,real-time data acquisition,real-time transmission,and automatic inversionare realized.Through dynamic imaging analysis of the electrical anomaly characteristics of the leakage area and comparison between corresponding rainfall events,the leakage range and resistivity changes,the reliability and efficiency of dam leakagedete ction are significantly improved.This achieves long-termdynamic monitoring of dam leakage and provides a new perspective for the safe operation and maintenance of reservoirs. 展开更多
关键词 geophysical detection time-lapse resistivity method IoT and 5G technologies dynamic monitoring
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Machine learning-based investigation of uplift resistance in special-shaped shield tunnels using numerical finite element modeling
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作者 ZHANG Wengang YE Wenyu +2 位作者 SUN Weixin LIU Zhicheng LI Zhengchuan 《土木与环境工程学报(中英文)》 北大核心 2026年第1期1-13,共13页
The uplift resistance of the soil overlying shield tunnels significantly impacts their anti-floating stability.However,research on uplift resistance concerning special-shaped shield tunnels is limited.This study combi... The uplift resistance of the soil overlying shield tunnels significantly impacts their anti-floating stability.However,research on uplift resistance concerning special-shaped shield tunnels is limited.This study combines numerical simulation with machine learning techniques to explore this issue.It presents a summary of special-shaped tunnel geometries and introduces a shape coefficient.Through the finite element software,Plaxis3D,the study simulates six key parameters—shape coefficient,burial depth ratio,tunnel’s longest horizontal length,internal friction angle,cohesion,and soil submerged bulk density—that impact uplift resistance across different conditions.Employing XGBoost and ANN methods,the feature importance of each parameter was analyzed based on the numerical simulation results.The findings demonstrate that a tunnel shape more closely resembling a circle leads to reduced uplift resistance in the overlying soil,whereas other parameters exhibit the contrary effects.Furthermore,the study reveals a diminishing trend in the feature importance of buried depth ratio,internal friction angle,tunnel longest horizontal length,cohesion,soil submerged bulk density,and shape coefficient in influencing uplift resistance. 展开更多
关键词 special-shaped tunnel shield tunnel uplift resistance numerical simulation machine learning
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High resistance SO_(2) adsorbent of Fe-Ce-La oxides@Si-Al carrier for arsenic capture from middle-low-temperature flue gas
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作者 WEN Hangyu HOU Shuyang +2 位作者 WANG Kai ZHANG Kaihua ZHANG Kai Beijing 《燃料化学学报(中英文)》 北大核心 2026年第2期166-179,共14页
It is crucial to develop arsenic removal adsorbents with strong sulfur resistance under middle-low-temperature flue gas conditions(<400℃).In this work,five Fe-Ce-La oxides were prepared by co-precipitation method,... It is crucial to develop arsenic removal adsorbents with strong sulfur resistance under middle-low-temperature flue gas conditions(<400℃).In this work,five Fe-Ce-La oxides were prepared by co-precipitation method,and FeCeLaO/SiO_(2)-Al_(2)O_(3) composite adsorbents were prepared by coupling fly ash-based Si-Al carriers.The active components Fe-Ce-La oxides and Si-Al carriers were characterized by TPD,TG,XRF,BET and XPS,respectively.The effects of temperature,Si/Al ratio and FeCeLaO loading rate on the sulfur resistance were investigated.Results show that the SO_(2) promotes the arsenic removal of Fe_(2)O_(3),CeLaO and FeCeLaO.At 400℃,the arsenic removal efficiencies of the three oxides increase from 45.3%,72.5% and 81.3% without SO_(2) to 62.6%,80.5%and 91.0%,respectively.The SO_(2) inhibits the arsenic removal of La_(2)O_(2)CO_(3) and FeLaO,and the inhibition effect is pronounced at high temperatures.The sulfur poisoning resistance of Si-Al carriers increases with the increase of Si/Al ratio.When the Si/Al ratio is increased to 9.74,the arsenic removal efficiency in the SO_(2) environment is 13.9% higher than that in the absence of SO_(2).Introducing FeCeLaO active components is beneficial for enhancing the SO_(2) poisoning resistance of Si-Al carriers.The strong sulfur resistance of the FeCeLaO/SiO_(2)-Al_(2)O_(3) composite adsorbent results from multiple factors:protective effects of Ce on Fe,La and Al;sulfation-induced generation of Ce^(3+)and surface-adsorbed oxygen;and strong surface acidity of SiO_(2). 展开更多
关键词 arsenic removal sulfur resistance flue gas Fe-Ce-La oxides fly ash
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In-Flight Heating Process of Cerium Oxide Powders in Radio Frequency Thermal Plasma Considering Thermal Resistance Effect
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作者 Su Yi Liu Ruizhe +3 位作者 Ahmad Hilal Zhao Peng Jin Xingyue Zhu Hailong 《稀有金属材料与工程》 北大核心 2026年第3期581-594,共14页
The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF... The in-flight heating process of cerium dioxide(CeO_(2))powders was investigated through experiments and numerical simulations.In the experiment,CeO_(2)powder(average size of 30μm)was injected into radio-frequency(RF)argon plasma,and the temperatures were measured using a DPV-2000 monitor.A model combining the electromagnetism,thermal flow,and heat transfer characteristics of powder during in-flight heating in argon plasma was proposed.The melting processes of CeO_(2)powders of different diameters,with and without thermal resistance effect,were investigated.Results show that the heating process of CeO_(2)powder particles consists of three main stages,one of which is relevant to a dimensionless parameter known as the Biot number.When the Biot value≥0.1,thermal resistance increases significantly,especially for the larger powders.The predicted temperature of the particles at the outlet(1800–2880 K)is in good agreement with the experimental result. 展开更多
关键词 RF thermal plasma thermal resistance effect heating process Biot number
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Research Status and Prospects of Platinum Group Metal Coatings with High-Temperature Oxidation Resistance
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作者 Ding Chenxi Liu Zhongyu +3 位作者 Fang Zhen Wang Haoxu Lv Biao Hu Zhenfeng 《稀有金属材料与工程》 北大核心 2026年第2期333-344,共12页
Platinum group metals have high melting points,strong corrosion resistance,stable chemical properties,and low oxygen permeability in high-temperature oxygen-containing environments.As thermal protective coating materi... Platinum group metals have high melting points,strong corrosion resistance,stable chemical properties,and low oxygen permeability in high-temperature oxygen-containing environments.As thermal protective coating materials,they have gained essential applications in the aerospace field and have excellent prospects for application in frontier military fields,such as protecting hot-end components of hypersonic aircraft.This research reviewed the latest research progress of platinum group metal coatings with hightemperature oxidation resistance,including coating preparation techniques,oxidation failure,and alloying modification.The leading preparation techniques of current platinum group metal coatings were discussed,as well as the advantages and disadvantages of various existing preparation techniques.Besides,the intrinsic properties,failure forms,and failure mechanisms of coatings of single platinum group metal in high-temperature oxygen-containing environments were analyzed.On this basis,the necessity,main methods,and main achievements of alloying modification of platinum group metals were summarized.Finally,the future development of platinum group coatings with high-temperature oxidation resistance was discussed and prospected. 展开更多
关键词 platinum group metal coatings preparation technique high temperature oxidation resistance alloying modification
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How do nanomaterials influence the spread of antibiotic resistance genes in aquatic environments?
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作者 Yun Bai Shengnan Li Shih-Hsin Ho 《Chinese Chemical Letters》 2026年第1期186-197,共12页
Antibiotic resistance genes(ARGs) are recognized as a primary threat to the sustainability of environment and human health in the 21^(st) century.Nanomaterials(NMs) have attracted substantial attention due to their un... Antibiotic resistance genes(ARGs) are recognized as a primary threat to the sustainability of environment and human health in the 21^(st) century.Nanomaterials(NMs) have attracted substantial attention due to their unique dimensions and structures.Unfortunately,emerging evidence suggests that NMs may facilitate the transmission of ARGs.It is crucial to elucidate how NMs affect the evolution and dissemination of ARGs.The current review comprehensively examines the role of NMs in the widespread transmission of ARGs in aquatic environments and the underlying mechanisms involved in the process.It aims to clarify the effects and mechanisms of NMs on the horizontal gene transfer processes that are associated with ARGs,including the enhancement of cell membrane permeability,the formation of nanopores on membranes,promotion of mutagenesis,and the generation of reactive oxygen species(ROSs).Furthermore,the trade-off between the removal of ARGs and horizontal transfer has been elucidated.The review aspires to guide future research directions,advance knowledge on the implications of NMs in the field of ARGs' transmission,and provide a theoretical foundation for the development of safer and more effective applications of NMs. 展开更多
关键词 Antibiotic resistance genes Antibiotic resistance bacteria NANOMATERIALS Horizontal gene transfer Aquatic environments
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Dual carbapenem-fluoroquinolone resistance in community-onset pediatric urinary tract infections:Phenotypic-genotypic integration in three cases
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作者 C Quang Ngo D Hung Tran +2 位作者 T Trung Huynh Q Nhu Nguyen H My Le 《Asian Pacific Journal of Tropical Medicine》 2026年第1期45-48,共4页
Urinary tract infections(UTIs)are among the most prevalent pediatric bacterial infections,and undertreated episodes may lead to renal scarring,hypertension,or chronic kidney disease.Multidrug-resistant(MDR)Enterobacte... Urinary tract infections(UTIs)are among the most prevalent pediatric bacterial infections,and undertreated episodes may lead to renal scarring,hypertension,or chronic kidney disease.Multidrug-resistant(MDR)Enterobacterales have been increasingly reported in children,with higher rates in Asian and Middle Eastern settings than in high-income countries[1,2]. 展开更多
关键词 phenotypic genotypic integration chronic kidney diseasemultidrug resistant mdr enterobacterales community onset pediatric urinary tract infections renal scarring urinary tract infections dual carbapenem fluoroquinolone resistance multidrug resistant enterobacterales
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The Role of Exosomes as a Key Factor of Cytostatic Resistance in Cancer:Mechanisms of Action,Potential Biomarkers,and Possible Exosome-Based Therapies
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作者 Sandra Kałużna Monika Świerczewska +3 位作者 Sylwia Ciesiółka Małgorzata Partyka Michał Nowicki Karolina Wojtowicz 《Oncology Research》 2026年第1期23-56,共34页
The last research focuses on the role of exosomes in cancer treatment.Exosomes are extracellular vesicles.They can be secreted by cancer cells,and they can modulate chemotherapy sensitivity.Determining exosomal conten... The last research focuses on the role of exosomes in cancer treatment.Exosomes are extracellular vesicles.They can be secreted by cancer cells,and they can modulate chemotherapy sensitivity.Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases.Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers.Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer.Exosomal proteins remain reliable biomarkers also.Exosomes have emerged as promising therapeutic candidates.Their biological properties render them ideal vectors for drug delivery.Genetic modification of exosomes is an effective way to deliver material capable of modulating cellular pathways involved in drug resistance.Furthermore,exosomes have been explored as carriers for metal-chelating agents.Integrating exosome-based therapies with traditional anticancer agents aims to exploit the natural targeting abilities of exosomes to enhance drug delivery.Despite the dynamic development of this field,many mechanisms of exosome action remain incompletely understood.Therefore,it is necessary to conduct further studies that will allow for a better understanding of their role in the process of resistance and will enable the development of effective therapeutic strategies. 展开更多
关键词 EXOSOMES drug resistance CANCER
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QTL-Seq Identifies Genomic Regions Associated with Resistance to Bipolaris oryzae and Their Association with Defense Related Enzyme Activity in Rice
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作者 Jagjeet Singh LORE Sanjay KUMAR +4 位作者 Dharminder BHATIA Mandeep Singh HUNJAN Rishabh MAHESHWARI Dayananda Veeriah Patil Jyoti JAIN 《Rice science》 2026年第1期15-20,I0028-I0033,共12页
Brown spot(BS)of rice,caused by Bipolaris oryzae,is a serious concern that not only causes quantitative losses but also affects grain quality.To manage this disease,the use of resistant genetic sources and QTLs is an ... Brown spot(BS)of rice,caused by Bipolaris oryzae,is a serious concern that not only causes quantitative losses but also affects grain quality.To manage this disease,the use of resistant genetic sources and QTLs is an eco-friendly and economical option.In the current study,F_(3) progenies derived from a cross of susceptible parent PMS-18-B(PAU 10845-1-1-1-1)×resistant parent RP Path 77(RP patho-17)were used to identify potential QTLs linked to BS resistance and to associate this resistance with a temporal spike in defense-related enzymes. 展开更多
关键词 bipolaris oryzae temporal spik resistANCE defense related enzymes bipolaris oryzaeis identify potential qtls resistant genetic sources quantitative trait loci
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High-throughput Sequencing for Tuberculosis Diagnosis and Antimicrobial Resistance Detection:Progress,Challenges,and Future Perspectives
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作者 Lulu Zhang Junping Peng 《Biomedical and Environmental Sciences》 2026年第2期223-233,共11页
Tuberculosis(TB)continues to pose a significant threat to global public health,necessitating rapid and precise diagnostic methods and comprehensive detection of antimicrobial resistance(AMR)to facilitate timely clinic... Tuberculosis(TB)continues to pose a significant threat to global public health,necessitating rapid and precise diagnostic methods and comprehensive detection of antimicrobial resistance(AMR)to facilitate timely clinical management.Traditional diagnostic techniques suffer from extended turnaround times and limited ability to comprehensively profile AMR,often resulting in delayed therapeutic interventions.Highthroughput sequencing(HTS)technologies have revolutionized pathogen research by significantly improving diagnostic speed and accuracy.In the context of TB,diverse sequencing strategies and platforms are being employed to fulfill specific research goals,ranging from elucidating the molecular mechanisms underlying AMR to characterizing the genomic diversity among clinical isolates.This review systematically examines current progress in the application of HTS for rapid pathogen identification,comprehensive AMR profiling,epidemiological studies,advances in novel drugs,and vaccine development.Furthermore,we address existing technological limitations and bioinformatics challenges and explore the future directions necessary for effectively integrating HTS-based methodologies into global TB control efforts. 展开更多
关键词 TUBERCULOSIS Antimicrobial resistance High-throughput sequencing
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Telomere-to-telomere genome assembly reveals the genomic architecture of disease resistance and yield coordination in elite wheat YM33
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作者 Guofeng Lv Yating Wang +15 位作者 Heping Zhang Yuning Shen Wenjing Hu Datong Liu Mengmeng Liu Wenna Wang Yuwen Gao Caixia Lan Tongde Bie Hongya Wu Wei Chen Yong Zhang Jianwei Zhang Chao He Wenhao Yan Derong Gao 《Molecular Plant》 2026年第2期213-216,共4页
Wheat(Triticum aestivum)faces significant threats from diseases such as powdery mildew(Blumeria graminis)and Fusarium head blight(FHB;caused by Fusarium graminearum),which cause severe yield losses.Moreover,the antago... Wheat(Triticum aestivum)faces significant threats from diseases such as powdery mildew(Blumeria graminis)and Fusarium head blight(FHB;caused by Fusarium graminearum),which cause severe yield losses.Moreover,the antagonism between yield-related traits and disease resistance makes yield resistance coordination a major challenge in wheat breeding.The lack of genetic resources combining both disease resistance and high yield constrains the elucidation of underlying resistance-yield trade-off mechanisms,thereby hindering the development of high-yield and disease-resistant wheat cultivars.Remarkably,Yangmai 33(YM33),a notable wheat cultivar with resistance to both powdery mildew and FHB as well as high-yield performance,was recently developed.It offers a unique opportunity to dissect the genomic architecture underlying the coordination between disease resistance and yield. 展开更多
关键词 fusarium head blight fhbcaused powdery mildew blumeria yield resistance coordination telomere telomere genome assembly disease resistance elite wheat genetic resources genomic architecture
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