Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold...Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold great promise as miniature detectives capable of detecting mi RNAs within cells.However,current nanoprobes face a challenge in achieving the required precision for accurate miRNA detection,particularly within the intricate confines of the cellular microenvironment,due to interference with biological autofluorescence,off-target effects,and a lack of spatiotemporal control.Here,we have designed a dual-stimuli responsive DNA tracker,synergistically utilizing specific intracellular cues and external triggers,which enables spatiotemporal-controlled and precise detection and imaging of miRNAs"on demand".The tracker,which combines zeolitic imidazolate framework-67(ZIF-67)and unique hairpin DNA structures,effectively anchored onto the ZIF-67 through electrostatic interactions,remains in a dormant state until activated by abundant cellular ATP,resulting in the release of the hairpin structures that include a PC linker incorporated into the loop region.Subsequent irradiation triggers specific recognition of the target miRNA.The newly developed HP-PC-BT@ZIF-67 tracker demonstrates precise spatiotemporal mi RNA detection and exhibits excellent biocompatibility,enabling specific mi RNA recognition"on demand"within cancer cells.This research presents a reliable mi RNA imaging platform in the intricate cellular environment,opening up the possibilities for precise biomedical analysis and disease diagnosis.展开更多
We demonstrate the temporal manipulation of spatiotemporal optical vortices(STOVs)by utilizing Airy pulses.By combining a STOV with an Airy temporal profile,the STOV exhibits nondispersive,self-accelerating,and self-h...We demonstrate the temporal manipulation of spatiotemporal optical vortices(STOVs)by utilizing Airy pulses.By combining a STOV with an Airy temporal profile,the STOV exhibits nondispersive,self-accelerating,and self-healing features inherited from the Airy pulse propagation.Such features will enhance the control of STOVs in time.展开更多
Compared with electrons,there is one distinct feature of photons,known as multiple physical dimensions.Frequency/wavelength,time,complex amplitude and polarization are typical physical dimensions of photons.Very recen...Compared with electrons,there is one distinct feature of photons,known as multiple physical dimensions.Frequency/wavelength,time,complex amplitude and polarization are typical physical dimensions of photons.Very recently,the spatial structure of photons,the only known physical dimension left,has attracted increasing interest in full access of photons worthy of exploration.Manipulating these physical dimensions of photons enables a diversity of light related applications such as trapping,sensing,metrology,microscopy,imaging,quantum information processing and optical communications.展开更多
The creation and manipulation of photonic skyrmions provide a novel degree of freedom for light-matter interactions,optical communication and nanometrology.Since the localized vortex within skyrmions arises from the t...The creation and manipulation of photonic skyrmions provide a novel degree of freedom for light-matter interactions,optical communication and nanometrology.Since the localized vortex within skyrmions arises from the twist and curl of the phase structure,the orbital angular momentum of light is essential for their construction.While numerous skyrmionic textures have been proposed,they are formed within the spatial domain and induced by the longitudinal orbital angular momentum.Here we theoretically propose and experimentally observe spatiotemporal skyrmions within a picosecond pulse wavepacket,generated through vectorial sculpturing of spatiotemporal wavepackets.The skyrmionic textures emerge within the spatiotemporal distribution of a vector field encompass all possible polarization states.Constructed upon the transverse orbital angular momentum,spatiotemporal skyrmions,in contrast to spatial skyrmions,exhibit no helical twisting perpendicular to the skyrmion plane,demonstrating potential stability against deformations or perturbations.These results expand the skyrmion family and offer new insights into optical quasiparticles,potentially leading to advanced applications in optical metrology,sensing,and data storage.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21904095,22004089)Peiyang Talents Project of Tianjin University+1 种基金Young Thousand Talented ProgramProgram of Tianjin Science and Technology Major Project and Engineering(No.19ZXYXSY00090)。
文摘Nanomaterials provide an ideal platform for biomolecular display due to their dimensions approach the molecular scale,facilitating binding behavior akin to that observed in solution-based processes.DNA nanoprobes hold great promise as miniature detectives capable of detecting mi RNAs within cells.However,current nanoprobes face a challenge in achieving the required precision for accurate miRNA detection,particularly within the intricate confines of the cellular microenvironment,due to interference with biological autofluorescence,off-target effects,and a lack of spatiotemporal control.Here,we have designed a dual-stimuli responsive DNA tracker,synergistically utilizing specific intracellular cues and external triggers,which enables spatiotemporal-controlled and precise detection and imaging of miRNAs"on demand".The tracker,which combines zeolitic imidazolate framework-67(ZIF-67)and unique hairpin DNA structures,effectively anchored onto the ZIF-67 through electrostatic interactions,remains in a dormant state until activated by abundant cellular ATP,resulting in the release of the hairpin structures that include a PC linker incorporated into the loop region.Subsequent irradiation triggers specific recognition of the target miRNA.The newly developed HP-PC-BT@ZIF-67 tracker demonstrates precise spatiotemporal mi RNA detection and exhibits excellent biocompatibility,enabling specific mi RNA recognition"on demand"within cancer cells.This research presents a reliable mi RNA imaging platform in the intricate cellular environment,opening up the possibilities for precise biomedical analysis and disease diagnosis.
基金supported by the Pusan National University Research Grant,2022,and the National Research Foundation of Korea(NRF)funded by the Korea government(MSIT)(No.2022R1A2C1091890).
文摘We demonstrate the temporal manipulation of spatiotemporal optical vortices(STOVs)by utilizing Airy pulses.By combining a STOV with an Airy temporal profile,the STOV exhibits nondispersive,self-accelerating,and self-healing features inherited from the Airy pulse propagation.Such features will enhance the control of STOVs in time.
文摘Compared with electrons,there is one distinct feature of photons,known as multiple physical dimensions.Frequency/wavelength,time,complex amplitude and polarization are typical physical dimensions of photons.Very recently,the spatial structure of photons,the only known physical dimension left,has attracted increasing interest in full access of photons worthy of exploration.Manipulating these physical dimensions of photons enables a diversity of light related applications such as trapping,sensing,metrology,microscopy,imaging,quantum information processing and optical communications.
基金financial support from the National Natural Science Foundation of China(12434012,12204309,12304367)Shanghai Rising-Star Program(22YF1415200,23YF1415800)Shanghai Post-doctoral Excellence Program(2023533).
文摘The creation and manipulation of photonic skyrmions provide a novel degree of freedom for light-matter interactions,optical communication and nanometrology.Since the localized vortex within skyrmions arises from the twist and curl of the phase structure,the orbital angular momentum of light is essential for their construction.While numerous skyrmionic textures have been proposed,they are formed within the spatial domain and induced by the longitudinal orbital angular momentum.Here we theoretically propose and experimentally observe spatiotemporal skyrmions within a picosecond pulse wavepacket,generated through vectorial sculpturing of spatiotemporal wavepackets.The skyrmionic textures emerge within the spatiotemporal distribution of a vector field encompass all possible polarization states.Constructed upon the transverse orbital angular momentum,spatiotemporal skyrmions,in contrast to spatial skyrmions,exhibit no helical twisting perpendicular to the skyrmion plane,demonstrating potential stability against deformations or perturbations.These results expand the skyrmion family and offer new insights into optical quasiparticles,potentially leading to advanced applications in optical metrology,sensing,and data storage.
基金Foundation item:Science and Technology Commission of Shanghai Municipality(No.19060502500)National Natural Science Foundation of China(Nos. 12104309,92050202)Shanghai Sailing Program(No.21YF1431500)。
