A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source di...A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source disturbances are addressed according to their specific characteristics as follows:(A)an MTN data-driven model,which is used for uncertainty description,is designed accompanied with the mechanism model to represent the unmanned systems;(B)an adaptive MTN filter is used to remove the influence of the internal disturbance;(C)an MTN disturbance observer is constructed to estimate and compensate for the influence of the external disturbance;(D)the Extended Kalman Filter(EKF)algorithm is utilized as the learning mechanism for MTNs.Second,to address the time-delay effect,a recursiveτstep-ahead MTN predictive model is designed utilizing recursive technology,aiming to mitigate the impact of time-delay,and the EKF algorithm is employed as its learning mechanism.Then,the MTN predictive control law is designed based on the quadratic performance index.By implementing the proposed composite controller to unmanned systems,simultaneous feedforward compensation and feedback suppression to the multi-source disturbances are conducted.Finally,the convergence of the MTN and the stability of the closed-loop system are established utilizing the Lyapunov theorem.Two exemplary applications of unmanned systems involving unmanned vehicle and rigid spacecraft are presented to validate the effectiveness of the proposed approach.展开更多
In global navigation satellite system denial environment,cross-view geo-localization based on image retrieval presents an exceedingly critical visual localization solution for Unmanned Aerial Vehicle(UAV)systems.The e...In global navigation satellite system denial environment,cross-view geo-localization based on image retrieval presents an exceedingly critical visual localization solution for Unmanned Aerial Vehicle(UAV)systems.The essence of cross-view geo-localization resides in matching images containing the same geographical targets from disparate platforms,such as UAV-view and satellite-view images.However,images of the same geographical targets may suffer from occlusions and geometric distortions due to variations in the capturing platform,view,and timing.The existing methods predominantly extract features by segmenting feature maps,which overlook the holistic semantic distribution and structural information of objects,resulting in loss of image information.To address these challenges,dilated neighborhood attention Transformer is employed as the feature extraction backbone,and Multi-feature representations based on Multi-scale Hierarchical Contextual Aggregation(MMHCA)is proposed.In the proposed MMHCA method,the multiscale hierarchical contextual aggregation method is utilized to extract contextual information from local to global across various granularity levels,establishing feature associations of contextual information with global and local information in the image.Subsequently,the multi-feature representations method is utilized to obtain rich discriminative feature information,bolstering the robustness of model in scenarios characterized by positional shifts,varying distances,and scale ambiguities.Comprehensive experiments conducted on the extensively utilized University-1652 and SUES-200 benchmarks indicate that the MMHCA method surpasses the existing techniques.showing outstanding results in UAV localization and navigation.展开更多
Let F_(1)be the virtual field consisting of one element and(Q,I)a string pair.In this paper,we study the representations of string pairs over the virtual field F_(1).It is proved that an indecomposable F_(1)-represent...Let F_(1)be the virtual field consisting of one element and(Q,I)a string pair.In this paper,we study the representations of string pairs over the virtual field F_(1).It is proved that an indecomposable F_(1)-representation is either a string representation or a band representation by using the coefficient quivers.It is worth noting that for a given band and a positive integer,there exists a unique band representation up to isomorphism.展开更多
Artificial intelligence(AI)researchers and cheminformatics specialists strive to identify effective drug precursors while optimizing costs and accelerating development processes.Digital molecular representation plays ...Artificial intelligence(AI)researchers and cheminformatics specialists strive to identify effective drug precursors while optimizing costs and accelerating development processes.Digital molecular representation plays a crucial role in achieving this objective by making molecules machine-readable,thereby enhancing the accuracy of molecular prediction tasks and facilitating evidence-based decision making.This study presents a comprehensive review of small molecular representations and AI-driven drug discovery downstream tasks utilizing these representations.The research methodology begins with the compilation of small molecule databases,followed by an analysis of fundamental molecular representations and the models that learn these representations from initial forms,capturing patterns and salient features across extensive chemical spaces.The study then examines various drug discovery downstream tasks,including drug-target interaction(DTI)prediction,drug-target affinity(DTA)prediction,drug property(DP)prediction,and drug generation,all based on learned representations.The analysis concludes by highlighting challenges and opportunities associated with machine learning(ML)methods for molecular representation and improving downstream task performance.Additionally,the representation of small molecules and AI-based downstream tasks demonstrates significant potential in identifying traditional Chinese medicine(TCM)medicinal substances and facilitating TCM target discovery.展开更多
The ancient tacit knowledge behind the logic system permeated the culture and promoted numerous impactful inventions throughout the history. Traditional Chinese medicine with its effectiveness should also have stemmed...The ancient tacit knowledge behind the logic system permeated the culture and promoted numerous impactful inventions throughout the history. Traditional Chinese medicine with its effectiveness should also have stemmed out from such logic system. This article aims to rearticulate the underlying lucid multi-dimensional logic system, which faded in obscurity only because of time-out loss of the mid-right concept. Retracing this past tacit but important concept could uncover a multi-dimensional system over a point relating to all matters while capturing the central core of the matter. The seemingly unmanageable multidimensional logic was strengthened by verification processes which affirmed its further extensions, and made up the language of the people, the concepts of yin-yang(阴阳), and the development of extensions of Ba Gua(八卦) derivatives, which furthered the interpretation of the space-time properties and Chinese medicine.展开更多
Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe_(2)-based anodes.Therefore,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial...Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe_(2)-based anodes.Therefore,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial for acquiring stable NiSe2-based materials for sodium-ion batteries(SIBs),Herein,a stress dissipation strategy driven by architecture engineering is proposed,which can achieve ultrafast and ultralong sodium storage properties.Different from the conventional sphere-like or rod-like architecture,the three-dimensional(3D)flower-like NiSe_(2)@C composite is delicately designed and assembled with onedimensional nanorods and carbon framework.More importantly,the fundamental mechanism of improved structure stability is unveiled by simulations and experimental results simultaneously.It demonstrates that this designed multidimensional flower-like architecture with dispersed nanorods can balance the structural mismatch,avoid concentrated local strain,and relax the internal stress,mainly induced by the unavoidable volume variation during the repeated conversion processes.Moreover,it can provide more Na^(+)-storage sites and multi-directional migration pathways,leading to a fast Na^(+)-migration channel with boosted reaction kinetic.As expected,it delivers superior rate performance(441 mA h g^(-1)at 5.0 A g^(-1))and long cycling stability(563 mA h g^(-1)at 1.0 A g^(-1)over 1000 cycles)for SIBs.This work provides useful insights for designing high-performance conversion-based anode materials for SIBs.展开更多
This paper explores whole-process engineering consulting,including its application models in public buildings and elderly-friendly projects,such as service integration and whole lifecycle management.It also addresses ...This paper explores whole-process engineering consulting,including its application models in public buildings and elderly-friendly projects,such as service integration and whole lifecycle management.It also addresses the construction of multi-dimensional collaborative theoretical models,public space streamline organization,and other aspects,emphasizing the importance of multi-dimensional collaboration.Additionally,it highlights the role of talent cultivation and digital transformation in enhancing project efficiency.展开更多
The multi-dimensional interactive teaching model significantly enhances the effectiveness of college English instruction by emphasizing dynamic engagement between teachers and students,as well as among students themse...The multi-dimensional interactive teaching model significantly enhances the effectiveness of college English instruction by emphasizing dynamic engagement between teachers and students,as well as among students themselves.This paper explores practical strategies for implementing this model,focusing on four key aspects:deepening teachers’understanding of the model through continuous learning,innovating interactive methods such as questioning techniques and practical activities,leveraging modern technology to integrate resources and track learning progress,and establishing a communication platform that centers on student participation.By adopting these approaches,the model fosters a student-centered classroom environment,improves comprehensive English application skills,and optimizes overall teaching quality.展开更多
During the critical transformation period of landscape architecture major after the adjustment of disciplinary structure and the changes in market demand,private colleges and universities,as important places for culti...During the critical transformation period of landscape architecture major after the adjustment of disciplinary structure and the changes in market demand,private colleges and universities,as important places for cultivating local talents,have pain points such as uneven quality of teachers and students and weak innovation and practice.The practice system with“multi-dimensional Integration”integrates four dimensions:interdisciplinary integration,spatial and temporal intersection,historical inheritance,and behavioral activity,deepens the disciplinary connotation,and integrates the three elements of nature,humanity,and technology,aiming to provide a new path for private colleges and universities to cultivate application-oriented and compound talents with innovative capabilities.In terms of optimizing talent cultivation and adapting to industry changes,this system provides thinking and reference for landscape architecture major,helping the major reshape its core competitiveness and promoting educational innovation and industry development.展开更多
This paper proposes a reliability evaluation model for a multi-dimensional network system,which has potential to be applied to the internet of things or other practical networks.A multi-dimensional network system with...This paper proposes a reliability evaluation model for a multi-dimensional network system,which has potential to be applied to the internet of things or other practical networks.A multi-dimensional network system with one source element and multiple sink elements is considered first.Each element can con-nect with other elements within a stochastic connection ranges.The system is regarded as successful as long as the source ele-ment remains connected with all sink elements.An importance measure is proposed to evaluate the performance of non-source elements.Furthermore,to calculate the system reliability and the element importance measure,a multi-valued decision diagram based approach is structured and its complexity is analyzed.Finally,a numerical example about the signal transfer station system is illustrated to analyze the system reliability and the ele-ment importance measure.展开更多
As a new research direction in contemporary cognitive science,predictive processing surpasses traditional computational representation and embodied cognition and has emerged as a new paradigm in cognitive science rese...As a new research direction in contemporary cognitive science,predictive processing surpasses traditional computational representation and embodied cognition and has emerged as a new paradigm in cognitive science research.The predictive processing theory advocates that the brain is a hierarchical predictive model based on Bayesian inference,and its purpose is to minimize the difference between the predicted world and the actual world,so as to minimize the prediction error.Predictive processing is therefore essentially a context-dependent model representation,an adaptive representational system designed to achieve its cognitive goals through the minimization of prediction error.展开更多
Constructing multi-dimensional hydrogen bond(H-bond)regulated single-molecule systems with multiemission remains a challenge.Herein,we report the design of a new excited-state intramolecular proton transfer(ESIPT)feat...Constructing multi-dimensional hydrogen bond(H-bond)regulated single-molecule systems with multiemission remains a challenge.Herein,we report the design of a new excited-state intramolecular proton transfer(ESIPT)featured chromophore(HBT-DPI)that shows flexible emission tunability via the multidimensional regulation of intra-and intermolecular H-bonds.The feature of switchable intramolecular Hbonds is induced via incorporating several hydrogen bond acceptors and donors into one single HBT-DPI molecule,allowing the“turn on/off”of ESIPT process by forming isomers with distinct intramolecular Hbonds configurations.In response to different external H-bonding environments,the obtained four types of crystal/cocrystals vary in the contents of isomers and the molecular packing modes,which are mainly guided by the intermolecular H-bonds,exhibiting non-emissive features or emissions ranging from green to orange.Utilizing the feature of intermolecular H-bond guided molecular packing,we demonstrate the utility of this fluorescent material for visualizing hydrophobic/hydrophilic areas on large-scale heterogeneous surfaces of modified poly(1,1-difluoroethylene)(PVDF)membranes and quantitatively estimating the surface hydrophobicity,providing a new approach for hydrophobicity/hydrophilicity monitoring and measurement.Overall,this study represents a new design strategy for constructing multi-dimensional hydrogen bond regulated ESIPT-based fluorescent materials that enable multiple emissions and unique applications.展开更多
Establishing and maintaining protected areas is a pivotal strategy for attaining the post-2020 biodiversity target. The conservation objectives of protected areas have shifted from a narrow emphasis on biodiversity to...Establishing and maintaining protected areas is a pivotal strategy for attaining the post-2020 biodiversity target. The conservation objectives of protected areas have shifted from a narrow emphasis on biodiversity to encompass broader considerations such as ecosystem stability, community resilience to climate change, and enhancement of human well-being. Given these multifaceted objectives, it is imperative to judiciously allocate resources to effectively conserve biodiversity by identifying strategically significant areas for conservation, particularly for mountainous areas. In this study, we evaluated the representativeness of the protected area network in the Qin ling Mountains concerning species diversity, ecosystem services, climate stability and ecological stability. The results indicate that some of the ecological indicators are spatially correlated with topographic gradient effects. The conservation priority areas predominantly lie in the northern foothills, the southeastern, and southwestern parts of the Qinling Mountain with areas concentrated at altitudes between 1,500-2,000 m and slopes between 40°-50° as hotspots. The conservation priority areas identified through the framework of inclusive conservation optimization account for 22.9 % of the Qinling Mountain. Existing protected areas comprise only 6.1 % of the Qinling Mountain and 13.18 % of the conservation priority areas. This will play an important role in achiev ing sustainable development in the region and in meeting the post-2020 biodiversity target. The framework can advance the different objectives of achieving a quadruple win and can also be extended to other regions.展开更多
Physics-informed neural networks(PINNs)are promising to replace conventional mesh-based partial tial differen-equation(PDE)solvers by offering more accurate and flexible PDE solutions.However,PINNs are hampered by the...Physics-informed neural networks(PINNs)are promising to replace conventional mesh-based partial tial differen-equation(PDE)solvers by offering more accurate and flexible PDE solutions.However,PINNs are hampered by the relatively slow convergence and the need to perform additional,potentially expensive training for new PDE parameters.To solve this limitation,we introduce LatentPINN,a framework that utilizes latent representations of the PDE parameters as additional(to the coordinates)inputs into PINNs and allows for training over the distribution of these parameters.Motivated by the recent progress on generative models,we promote using latent diffusion models to learn compressed latent representations of the distribution of PDE parameters as they act as input parameters for NN functional solutions.We use a two-stage training scheme in which,in the first stage,we learn the latent representations for the distribution of PDE parameters.In the second stage,we train a physics-informed neural network over inputs given by randomly drawn samples from the coordinate space within the solution domain and samples from the learned latent representation of the PDE parameters.Considering their importance in capturing evolving interfaces and fronts in various fields,we test the approach on a class of level set equations given,for example,by the nonlinear Eikonal equation.We share results corresponding to three Eikonal parameters(velocity models)sets.The proposed method performs well on new phase velocity models without the need for any additional training.展开更多
Considering that the algorithm accuracy of the traditional sparse representation models is not high under the influence of multiple complex environmental factors,this study focuses on the improvement of feature extrac...Considering that the algorithm accuracy of the traditional sparse representation models is not high under the influence of multiple complex environmental factors,this study focuses on the improvement of feature extraction and model construction.Firstly,the convolutional neural network(CNN)features of the face are extracted by the trained deep learning network.Next,the steady-state and dynamic classifiers for face recognition are constructed based on the CNN features and Haar features respectively,with two-stage sparse representation introduced in the process of constructing the steady-state classifier and the feature templates with high reliability are dynamically selected as alternative templates from the sparse representation template dictionary constructed using the CNN features.Finally,the results of face recognition are given based on the classification results of the steady-state classifier and the dynamic classifier together.Based on this,the feature weights of the steady-state classifier template are adjusted in real time and the dictionary set is dynamically updated to reduce the probability of irrelevant features entering the dictionary set.The average recognition accuracy of this method is 94.45%on the CMU PIE face database and 96.58%on the AR face database,which is significantly improved compared with that of the traditional face recognition methods.展开更多
In recent years,the transformer model has demonstrated excellent performance in computer vision(CV)applications.The key lies in its guided representation attention mechanism,which uses dot-product to depict complex fe...In recent years,the transformer model has demonstrated excellent performance in computer vision(CV)applications.The key lies in its guided representation attention mechanism,which uses dot-product to depict complex feature relationships,and comprehensively understands the context semantics to obtain feature weights.Then feature enhancement is implemented by guiding the target matrix through feature weights.However,the uncertainty and inconsistency of features are widespread that prone to confusion in the description of relationships within dot-product attention mechanisms.To solve this problem,this paper proposed a novel approximate-guided representation learning methodology for vision transformer.The kernelised matroids fuzzy rough set is defined,wherein the closed sets inside kernelised fuzzy information granules of matroids structures can constitute the subspace of lower approximation in rough sets.Thus,the kernel relation is employed to characterise image feature granules that will be reconstructed according to the independent set in matroids theory.Then,according to the characteristics of the closed set within matroids,the feature attention weight is formed by using the lower approximation to realise the approximate guidance of features.The approximate-guided representation mechanism can be flexibly deployed as a plug-and-play component in a wide range of CV tasks.Extensive empirical results demonstrate that the proposed method outperforms the majority of advanced prevalent models,especially in terms of robustness.展开更多
Clustering is a pivotal data analysis method for deciphering the charge transport properties of single molecules in break junction experiments.However,given the high dimensionality and variability of the data,feature ...Clustering is a pivotal data analysis method for deciphering the charge transport properties of single molecules in break junction experiments.However,given the high dimensionality and variability of the data,feature extraction remains a bottleneck in the development of efficient clustering methods.In this regard,extensive research over the past two decades has focused on feature engineering and dimensionality reduction in break junction conductance.However,extracting highly relevant features without expert knowledge remains an unresolved challenge.To address this issue,we propose a deep clustering method driven by task-oriented representation learning(CTRL)in which the clustering module serves as a guide for the representation learning(RepL)module.First,we determine an optimal autoencoder(AE)structure through a neural architecture search(NAS)to ensure efficient RepL;second,the RepL process is guided by a joint training strategy that combines AE reconstruction loss with the clustering objective.The results demonstrate that CTRL achieves excellent performance on both the generated and experimental data.Further inspection of the RepL step reveals that joint training robustly learns more compact features than the unconstrained AE or traditional dimensionality reduction methods,significantly reducing misclustering possibilities.Our method provides a general end-to-end automatic clustering solution for analyzing single-molecule break junction data.展开更多
Background Three-dimensional(3D)shape representation using mesh data is essential in various applications,such as virtual reality and simulation technologies.Current methods for extracting features from mesh edges or ...Background Three-dimensional(3D)shape representation using mesh data is essential in various applications,such as virtual reality and simulation technologies.Current methods for extracting features from mesh edges or faces struggle with complex 3D models because edge-based approaches miss global contexts and face-based methods overlook variations in adjacent areas,which affects the overall precision.To address these issues,we propose the Feature Discrimination and Context Propagation Network(FDCPNet),which is a novel approach that synergistically integrates local and global features in mesh datasets.Methods FDCPNet is composed of two modules:(1)the Feature Discrimination Module,which employs an attention mechanism to enhance the identification of key local features,and(2)the Context Propagation Module,which enriches key local features by integrating global contextual information,thereby facilitating a more detailed and comprehensive representation of crucial areas within the mesh model.Results Experiments on popular datasets validated the effectiveness of FDCPNet,showing an improvement in the classification accuracy over the baseline MeshNet.Furthermore,even with reduced mesh face numbers and limited training data,FDCPNet achieved promising results,demonstrating its robustness in scenarios of variable complexity.展开更多
This paper considers the notions of common sense and interobjectivity to articulate an understanding of how different cultural realities give rise to different construals of scientific phenomena across distinct cultur...This paper considers the notions of common sense and interobjectivity to articulate an understanding of how different cultural realities give rise to different construals of scientific phenomena across distinct cultures. Our main focus in this paper is on the social sciences. We propose a quadrant of different cultural–scientific stances from which the study of social phenomena is possible, based on the emic–etic dimension pertaining to the study of culture from contrasting perspectives. Although the emic–etic distinction is normal y applied in fields within the science of culture, it is proposed here that the distinction is in some ways germane to scientific practice in general, making it amenable for use in a culture of science(CoS) programme. The four perspectives that emerge from the quadrant are illustrated using exemplars. Different aspects of CoS—that is, scientific practice, scientific conventions and representations of science—are then discussed in further detail, including in two tables illustrating points of convergence and divergence between the East and West when it comes to different aspects of CoS.展开更多
基金co-supported by the National Key R&D Program of China(No.2023YFB4704400)the Zhejiang Provincial Natural Science Foundation of China(No.LQ24F030012)the National Natural Science Foundation of China General Project(No.62373033)。
文摘A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source disturbances are addressed according to their specific characteristics as follows:(A)an MTN data-driven model,which is used for uncertainty description,is designed accompanied with the mechanism model to represent the unmanned systems;(B)an adaptive MTN filter is used to remove the influence of the internal disturbance;(C)an MTN disturbance observer is constructed to estimate and compensate for the influence of the external disturbance;(D)the Extended Kalman Filter(EKF)algorithm is utilized as the learning mechanism for MTNs.Second,to address the time-delay effect,a recursiveτstep-ahead MTN predictive model is designed utilizing recursive technology,aiming to mitigate the impact of time-delay,and the EKF algorithm is employed as its learning mechanism.Then,the MTN predictive control law is designed based on the quadratic performance index.By implementing the proposed composite controller to unmanned systems,simultaneous feedforward compensation and feedback suppression to the multi-source disturbances are conducted.Finally,the convergence of the MTN and the stability of the closed-loop system are established utilizing the Lyapunov theorem.Two exemplary applications of unmanned systems involving unmanned vehicle and rigid spacecraft are presented to validate the effectiveness of the proposed approach.
基金supported by the National Natural Science Foundation of China(Nos.12072027,62103052,61603346 and 62103379)the Henan Key Laboratory of General Aviation Technology,China(No.ZHKF-230201)+3 种基金the Funding for the Open Research Project of the Rotor Aerodynamics Key Laboratory,China(No.RAL20200101)the Key Research and Development Program of Henan Province,China(Nos.241111222000 and 241111222900)the Key Science and Technology Program of Henan Province,China(No.232102220067)the Scholarship Funding from the China Scholarship Council(No.202206030079).
文摘In global navigation satellite system denial environment,cross-view geo-localization based on image retrieval presents an exceedingly critical visual localization solution for Unmanned Aerial Vehicle(UAV)systems.The essence of cross-view geo-localization resides in matching images containing the same geographical targets from disparate platforms,such as UAV-view and satellite-view images.However,images of the same geographical targets may suffer from occlusions and geometric distortions due to variations in the capturing platform,view,and timing.The existing methods predominantly extract features by segmenting feature maps,which overlook the holistic semantic distribution and structural information of objects,resulting in loss of image information.To address these challenges,dilated neighborhood attention Transformer is employed as the feature extraction backbone,and Multi-feature representations based on Multi-scale Hierarchical Contextual Aggregation(MMHCA)is proposed.In the proposed MMHCA method,the multiscale hierarchical contextual aggregation method is utilized to extract contextual information from local to global across various granularity levels,establishing feature associations of contextual information with global and local information in the image.Subsequently,the multi-feature representations method is utilized to obtain rich discriminative feature information,bolstering the robustness of model in scenarios characterized by positional shifts,varying distances,and scale ambiguities.Comprehensive experiments conducted on the extensively utilized University-1652 and SUES-200 benchmarks indicate that the MMHCA method surpasses the existing techniques.showing outstanding results in UAV localization and navigation.
文摘Let F_(1)be the virtual field consisting of one element and(Q,I)a string pair.In this paper,we study the representations of string pairs over the virtual field F_(1).It is proved that an indecomposable F_(1)-representation is either a string representation or a band representation by using the coefficient quivers.It is worth noting that for a given band and a positive integer,there exists a unique band representation up to isomorphism.
基金supported by the Shenzhen Key Laboratory of Intelligent Bioinformatics(No.ZDSYS20220422103800001)the Shenzhen Science and Technology Program(No.JCYJ20230807140709020)+2 种基金National Natural Science Foundation of China(Nos.62402489,U22A2041,and 62373172)the China Postdoctoral Science Foundation(No.2023M743688)Guangdong Basic and Applied Basic Research Foundation(Nos.2024A1515011960 and 2023A1515110570)。
文摘Artificial intelligence(AI)researchers and cheminformatics specialists strive to identify effective drug precursors while optimizing costs and accelerating development processes.Digital molecular representation plays a crucial role in achieving this objective by making molecules machine-readable,thereby enhancing the accuracy of molecular prediction tasks and facilitating evidence-based decision making.This study presents a comprehensive review of small molecular representations and AI-driven drug discovery downstream tasks utilizing these representations.The research methodology begins with the compilation of small molecule databases,followed by an analysis of fundamental molecular representations and the models that learn these representations from initial forms,capturing patterns and salient features across extensive chemical spaces.The study then examines various drug discovery downstream tasks,including drug-target interaction(DTI)prediction,drug-target affinity(DTA)prediction,drug property(DP)prediction,and drug generation,all based on learned representations.The analysis concludes by highlighting challenges and opportunities associated with machine learning(ML)methods for molecular representation and improving downstream task performance.Additionally,the representation of small molecules and AI-based downstream tasks demonstrates significant potential in identifying traditional Chinese medicine(TCM)medicinal substances and facilitating TCM target discovery.
文摘The ancient tacit knowledge behind the logic system permeated the culture and promoted numerous impactful inventions throughout the history. Traditional Chinese medicine with its effectiveness should also have stemmed out from such logic system. This article aims to rearticulate the underlying lucid multi-dimensional logic system, which faded in obscurity only because of time-out loss of the mid-right concept. Retracing this past tacit but important concept could uncover a multi-dimensional system over a point relating to all matters while capturing the central core of the matter. The seemingly unmanageable multidimensional logic was strengthened by verification processes which affirmed its further extensions, and made up the language of the people, the concepts of yin-yang(阴阳), and the development of extensions of Ba Gua(八卦) derivatives, which furthered the interpretation of the space-time properties and Chinese medicine.
基金the financial support from the Guangxi Natural Science Foundation(grant no.2021GXNSFDA075012,2023GXNSFGA026002)National Natural Science Foundation of China(52104298,22075073,52362027,52462029)Fundamental Research Funds for the Central Universities(531107051077).
文摘Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe_(2)-based anodes.Therefore,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial for acquiring stable NiSe2-based materials for sodium-ion batteries(SIBs),Herein,a stress dissipation strategy driven by architecture engineering is proposed,which can achieve ultrafast and ultralong sodium storage properties.Different from the conventional sphere-like or rod-like architecture,the three-dimensional(3D)flower-like NiSe_(2)@C composite is delicately designed and assembled with onedimensional nanorods and carbon framework.More importantly,the fundamental mechanism of improved structure stability is unveiled by simulations and experimental results simultaneously.It demonstrates that this designed multidimensional flower-like architecture with dispersed nanorods can balance the structural mismatch,avoid concentrated local strain,and relax the internal stress,mainly induced by the unavoidable volume variation during the repeated conversion processes.Moreover,it can provide more Na^(+)-storage sites and multi-directional migration pathways,leading to a fast Na^(+)-migration channel with boosted reaction kinetic.As expected,it delivers superior rate performance(441 mA h g^(-1)at 5.0 A g^(-1))and long cycling stability(563 mA h g^(-1)at 1.0 A g^(-1)over 1000 cycles)for SIBs.This work provides useful insights for designing high-performance conversion-based anode materials for SIBs.
文摘This paper explores whole-process engineering consulting,including its application models in public buildings and elderly-friendly projects,such as service integration and whole lifecycle management.It also addresses the construction of multi-dimensional collaborative theoretical models,public space streamline organization,and other aspects,emphasizing the importance of multi-dimensional collaboration.Additionally,it highlights the role of talent cultivation and digital transformation in enhancing project efficiency.
文摘The multi-dimensional interactive teaching model significantly enhances the effectiveness of college English instruction by emphasizing dynamic engagement between teachers and students,as well as among students themselves.This paper explores practical strategies for implementing this model,focusing on four key aspects:deepening teachers’understanding of the model through continuous learning,innovating interactive methods such as questioning techniques and practical activities,leveraging modern technology to integrate resources and track learning progress,and establishing a communication platform that centers on student participation.By adopting these approaches,the model fosters a student-centered classroom environment,improves comprehensive English application skills,and optimizes overall teaching quality.
基金Sponsored by the Quality Engineering Project of Education Department of Anhui Province(2022jyxm671)Research Team Project of Anhui Xinhua University(kytd202202)+1 种基金Key Project of Scientific Research(Natural Science)of Higher Education Institutions in Anhui Province(2022AH051861)Teaching Reform Research and Practice Quality Engineering Project of Anhui Xinhua University(2024jy035).
文摘During the critical transformation period of landscape architecture major after the adjustment of disciplinary structure and the changes in market demand,private colleges and universities,as important places for cultivating local talents,have pain points such as uneven quality of teachers and students and weak innovation and practice.The practice system with“multi-dimensional Integration”integrates four dimensions:interdisciplinary integration,spatial and temporal intersection,historical inheritance,and behavioral activity,deepens the disciplinary connotation,and integrates the three elements of nature,humanity,and technology,aiming to provide a new path for private colleges and universities to cultivate application-oriented and compound talents with innovative capabilities.In terms of optimizing talent cultivation and adapting to industry changes,this system provides thinking and reference for landscape architecture major,helping the major reshape its core competitiveness and promoting educational innovation and industry development.
基金supported by the National Natural Science Foundation of China(72101025,72271049),the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities,FRF-IDRY-24-024)the Hebei Natural Science Foundation(F2023501011)+1 种基金the Fundamental Research Funds for the Central Universities(FRF-TP-20-073A1)the R&D Program of Beijing Municipal Education Commission(KM202411232015).
文摘This paper proposes a reliability evaluation model for a multi-dimensional network system,which has potential to be applied to the internet of things or other practical networks.A multi-dimensional network system with one source element and multiple sink elements is considered first.Each element can con-nect with other elements within a stochastic connection ranges.The system is regarded as successful as long as the source ele-ment remains connected with all sink elements.An importance measure is proposed to evaluate the performance of non-source elements.Furthermore,to calculate the system reliability and the element importance measure,a multi-valued decision diagram based approach is structured and its complexity is analyzed.Finally,a numerical example about the signal transfer station system is illustrated to analyze the system reliability and the ele-ment importance measure.
基金supported by the National Social Science Fund of China’s project‘Philosophical Research on the Challenge of Artificial Cognition to Natural Cognition’(grant number 21&ZD061)
文摘As a new research direction in contemporary cognitive science,predictive processing surpasses traditional computational representation and embodied cognition and has emerged as a new paradigm in cognitive science research.The predictive processing theory advocates that the brain is a hierarchical predictive model based on Bayesian inference,and its purpose is to minimize the difference between the predicted world and the actual world,so as to minimize the prediction error.Predictive processing is therefore essentially a context-dependent model representation,an adaptive representational system designed to achieve its cognitive goals through the minimization of prediction error.
基金supported by the National Key R&D Program of China(No.2021YFC2103600)the National Natural Science Foundation of China(Nos.21878156,21978131,22275085,and 22278224)+2 种基金the Natural Science Foundation of Jiangsu Province(Nos.BK20200089 and BK20200691)the Project of Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the State Key Laboratory of Materials-Oriented Chemical Engineering(No.KL21-08).
文摘Constructing multi-dimensional hydrogen bond(H-bond)regulated single-molecule systems with multiemission remains a challenge.Herein,we report the design of a new excited-state intramolecular proton transfer(ESIPT)featured chromophore(HBT-DPI)that shows flexible emission tunability via the multidimensional regulation of intra-and intermolecular H-bonds.The feature of switchable intramolecular Hbonds is induced via incorporating several hydrogen bond acceptors and donors into one single HBT-DPI molecule,allowing the“turn on/off”of ESIPT process by forming isomers with distinct intramolecular Hbonds configurations.In response to different external H-bonding environments,the obtained four types of crystal/cocrystals vary in the contents of isomers and the molecular packing modes,which are mainly guided by the intermolecular H-bonds,exhibiting non-emissive features or emissions ranging from green to orange.Utilizing the feature of intermolecular H-bond guided molecular packing,we demonstrate the utility of this fluorescent material for visualizing hydrophobic/hydrophilic areas on large-scale heterogeneous surfaces of modified poly(1,1-difluoroethylene)(PVDF)membranes and quantitatively estimating the surface hydrophobicity,providing a new approach for hydrophobicity/hydrophilicity monitoring and measurement.Overall,this study represents a new design strategy for constructing multi-dimensional hydrogen bond regulated ESIPT-based fluorescent materials that enable multiple emissions and unique applications.
基金supported by the National Natural Science Foun-dation of China(Grant No.72349002).
文摘Establishing and maintaining protected areas is a pivotal strategy for attaining the post-2020 biodiversity target. The conservation objectives of protected areas have shifted from a narrow emphasis on biodiversity to encompass broader considerations such as ecosystem stability, community resilience to climate change, and enhancement of human well-being. Given these multifaceted objectives, it is imperative to judiciously allocate resources to effectively conserve biodiversity by identifying strategically significant areas for conservation, particularly for mountainous areas. In this study, we evaluated the representativeness of the protected area network in the Qin ling Mountains concerning species diversity, ecosystem services, climate stability and ecological stability. The results indicate that some of the ecological indicators are spatially correlated with topographic gradient effects. The conservation priority areas predominantly lie in the northern foothills, the southeastern, and southwestern parts of the Qinling Mountain with areas concentrated at altitudes between 1,500-2,000 m and slopes between 40°-50° as hotspots. The conservation priority areas identified through the framework of inclusive conservation optimization account for 22.9 % of the Qinling Mountain. Existing protected areas comprise only 6.1 % of the Qinling Mountain and 13.18 % of the conservation priority areas. This will play an important role in achiev ing sustainable development in the region and in meeting the post-2020 biodiversity target. The framework can advance the different objectives of achieving a quadruple win and can also be extended to other regions.
基金King Abdullah University of Science and Technol-ogy(KAUST)for supporting this research and the Seismic Wave Anal-ysis group for the supportive and encouraging environment.
文摘Physics-informed neural networks(PINNs)are promising to replace conventional mesh-based partial tial differen-equation(PDE)solvers by offering more accurate and flexible PDE solutions.However,PINNs are hampered by the relatively slow convergence and the need to perform additional,potentially expensive training for new PDE parameters.To solve this limitation,we introduce LatentPINN,a framework that utilizes latent representations of the PDE parameters as additional(to the coordinates)inputs into PINNs and allows for training over the distribution of these parameters.Motivated by the recent progress on generative models,we promote using latent diffusion models to learn compressed latent representations of the distribution of PDE parameters as they act as input parameters for NN functional solutions.We use a two-stage training scheme in which,in the first stage,we learn the latent representations for the distribution of PDE parameters.In the second stage,we train a physics-informed neural network over inputs given by randomly drawn samples from the coordinate space within the solution domain and samples from the learned latent representation of the PDE parameters.Considering their importance in capturing evolving interfaces and fronts in various fields,we test the approach on a class of level set equations given,for example,by the nonlinear Eikonal equation.We share results corresponding to three Eikonal parameters(velocity models)sets.The proposed method performs well on new phase velocity models without the need for any additional training.
基金the financial support from Natural Science Foundation of Gansu Province(Nos.22JR5RA217,22JR5RA216)Lanzhou Science and Technology Program(No.2022-2-111)+1 种基金Lanzhou University of Arts and Sciences School Innovation Fund Project(No.XJ2022000103)Lanzhou College of Arts and Sciences 2023 Talent Cultivation Quality Improvement Project(No.2023-ZL-jxzz-03)。
文摘Considering that the algorithm accuracy of the traditional sparse representation models is not high under the influence of multiple complex environmental factors,this study focuses on the improvement of feature extraction and model construction.Firstly,the convolutional neural network(CNN)features of the face are extracted by the trained deep learning network.Next,the steady-state and dynamic classifiers for face recognition are constructed based on the CNN features and Haar features respectively,with two-stage sparse representation introduced in the process of constructing the steady-state classifier and the feature templates with high reliability are dynamically selected as alternative templates from the sparse representation template dictionary constructed using the CNN features.Finally,the results of face recognition are given based on the classification results of the steady-state classifier and the dynamic classifier together.Based on this,the feature weights of the steady-state classifier template are adjusted in real time and the dictionary set is dynamically updated to reduce the probability of irrelevant features entering the dictionary set.The average recognition accuracy of this method is 94.45%on the CMU PIE face database and 96.58%on the AR face database,which is significantly improved compared with that of the traditional face recognition methods.
基金supported in part by the National Natural Science Foundation of China(62471205,62462040)Yunnan Fundamental Research Projects(202301AV070003)+1 种基金Major Science and Technology Projects in Yunnan Province(202302AG050009,202202AD080013)Sichuan Provincial Key Laboratory of Philosophy and Social Science for Language Intelligence in Special Education Major Project(YYZN-2024-1).
文摘In recent years,the transformer model has demonstrated excellent performance in computer vision(CV)applications.The key lies in its guided representation attention mechanism,which uses dot-product to depict complex feature relationships,and comprehensively understands the context semantics to obtain feature weights.Then feature enhancement is implemented by guiding the target matrix through feature weights.However,the uncertainty and inconsistency of features are widespread that prone to confusion in the description of relationships within dot-product attention mechanisms.To solve this problem,this paper proposed a novel approximate-guided representation learning methodology for vision transformer.The kernelised matroids fuzzy rough set is defined,wherein the closed sets inside kernelised fuzzy information granules of matroids structures can constitute the subspace of lower approximation in rough sets.Thus,the kernel relation is employed to characterise image feature granules that will be reconstructed according to the independent set in matroids theory.Then,according to the characteristics of the closed set within matroids,the feature attention weight is formed by using the lower approximation to realise the approximate guidance of features.The approximate-guided representation mechanism can be flexibly deployed as a plug-and-play component in a wide range of CV tasks.Extensive empirical results demonstrate that the proposed method outperforms the majority of advanced prevalent models,especially in terms of robustness.
基金supported by Guangxi Science and Technology Program(No.GuiKeAD23026291)Guangxi Science and Technology Major Project(No.AA22068057).
文摘Clustering is a pivotal data analysis method for deciphering the charge transport properties of single molecules in break junction experiments.However,given the high dimensionality and variability of the data,feature extraction remains a bottleneck in the development of efficient clustering methods.In this regard,extensive research over the past two decades has focused on feature engineering and dimensionality reduction in break junction conductance.However,extracting highly relevant features without expert knowledge remains an unresolved challenge.To address this issue,we propose a deep clustering method driven by task-oriented representation learning(CTRL)in which the clustering module serves as a guide for the representation learning(RepL)module.First,we determine an optimal autoencoder(AE)structure through a neural architecture search(NAS)to ensure efficient RepL;second,the RepL process is guided by a joint training strategy that combines AE reconstruction loss with the clustering objective.The results demonstrate that CTRL achieves excellent performance on both the generated and experimental data.Further inspection of the RepL step reveals that joint training robustly learns more compact features than the unconstrained AE or traditional dimensionality reduction methods,significantly reducing misclustering possibilities.Our method provides a general end-to-end automatic clustering solution for analyzing single-molecule break junction data.
基金Supported by the National Key R&D Program of China(2022YFC3803600).
文摘Background Three-dimensional(3D)shape representation using mesh data is essential in various applications,such as virtual reality and simulation technologies.Current methods for extracting features from mesh edges or faces struggle with complex 3D models because edge-based approaches miss global contexts and face-based methods overlook variations in adjacent areas,which affects the overall precision.To address these issues,we propose the Feature Discrimination and Context Propagation Network(FDCPNet),which is a novel approach that synergistically integrates local and global features in mesh datasets.Methods FDCPNet is composed of two modules:(1)the Feature Discrimination Module,which employs an attention mechanism to enhance the identification of key local features,and(2)the Context Propagation Module,which enriches key local features by integrating global contextual information,thereby facilitating a more detailed and comprehensive representation of crucial areas within the mesh model.Results Experiments on popular datasets validated the effectiveness of FDCPNet,showing an improvement in the classification accuracy over the baseline MeshNet.Furthermore,even with reduced mesh face numbers and limited training data,FDCPNet achieved promising results,demonstrating its robustness in scenarios of variable complexity.
文摘This paper considers the notions of common sense and interobjectivity to articulate an understanding of how different cultural realities give rise to different construals of scientific phenomena across distinct cultures. Our main focus in this paper is on the social sciences. We propose a quadrant of different cultural–scientific stances from which the study of social phenomena is possible, based on the emic–etic dimension pertaining to the study of culture from contrasting perspectives. Although the emic–etic distinction is normal y applied in fields within the science of culture, it is proposed here that the distinction is in some ways germane to scientific practice in general, making it amenable for use in a culture of science(CoS) programme. The four perspectives that emerge from the quadrant are illustrated using exemplars. Different aspects of CoS—that is, scientific practice, scientific conventions and representations of science—are then discussed in further detail, including in two tables illustrating points of convergence and divergence between the East and West when it comes to different aspects of CoS.
