Confronting the escalating global challenge of counterfeit products,developing advanced anticounterfeiting materials and structures with physical unclonable functions(PUFs)has become imperative.All-optical PUFs,distin...Confronting the escalating global challenge of counterfeit products,developing advanced anticounterfeiting materials and structures with physical unclonable functions(PUFs)has become imperative.All-optical PUFs,distinguished by their high output complexity and expansive response space,offer a promising alternative to conventional electronic counterparts.For practical authentications,the expansion of optical PUF keys usually involves intricate spatial or spectral shaping of excitation light using bulky external apparatus,which largely hinders the applications of optical PUFs.Here,we report a plasmonic PUF system based on heterogeneous nanostructures.The template-assisted shadow deposition technique was employed to adjust the morphological diversity of densely packed metal nanoparticles in individual PUFs.Transmission images were processed via a hash algorithm,and the generated PUF keys with a scalable capacity from 2875 to 243401 exhibit excellent uniqueness,randomness,and reproducibility.Furthermore,the wavelength and the polarization state of the excitation light are harnessed as two distinct expanding strategies,offering the potential for multiscenario applications via a single PUF.Overall,our reported plasmonic PUFs operated with the multidimensional expanding strategy are envisaged to serve as easy-to-integrate,easy-to-use systems and promise efficacy across a broad spectrum of applications,from anticounterfeiting to data encryption and authentication.展开更多
A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source di...A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source disturbances are addressed according to their specific characteristics as follows:(A)an MTN data-driven model,which is used for uncertainty description,is designed accompanied with the mechanism model to represent the unmanned systems;(B)an adaptive MTN filter is used to remove the influence of the internal disturbance;(C)an MTN disturbance observer is constructed to estimate and compensate for the influence of the external disturbance;(D)the Extended Kalman Filter(EKF)algorithm is utilized as the learning mechanism for MTNs.Second,to address the time-delay effect,a recursiveτstep-ahead MTN predictive model is designed utilizing recursive technology,aiming to mitigate the impact of time-delay,and the EKF algorithm is employed as its learning mechanism.Then,the MTN predictive control law is designed based on the quadratic performance index.By implementing the proposed composite controller to unmanned systems,simultaneous feedforward compensation and feedback suppression to the multi-source disturbances are conducted.Finally,the convergence of the MTN and the stability of the closed-loop system are established utilizing the Lyapunov theorem.Two exemplary applications of unmanned systems involving unmanned vehicle and rigid spacecraft are presented to validate the effectiveness of the proposed approach.展开更多
Space-time coding radar has been recently proposed and investigated.It is a radar framework which can perform transmit beamforming at the receiver.However,the range resolution decreases when the number of the transmit...Space-time coding radar has been recently proposed and investigated.It is a radar framework which can perform transmit beamforming at the receiver.However,the range resolution decreases when the number of the transmit element increases.A subarray-based space-time coding(sub-STC)radar is explored to alleviate the range resolution reduction.For the proposed radar configuration,an identical waveform is transmitted and it introduces a small time offset in different subarrays.The multidimensional ambiguity function of sub-STC radar is defined by considering resolutions in multiple domains including the range,Doppler,angle and probing direction.Analyses on properties of the multi-dimensional ambiguity function of the sub-STC radar with regard to the spatial coverage,resolution performance and low sidelobes are also given.Results reveal that the range resolution and low sidelobes performance are improved with the proposed approach.展开更多
The ancient tacit knowledge behind the logic system permeated the culture and promoted numerous impactful inventions throughout the history. Traditional Chinese medicine with its effectiveness should also have stemmed...The ancient tacit knowledge behind the logic system permeated the culture and promoted numerous impactful inventions throughout the history. Traditional Chinese medicine with its effectiveness should also have stemmed out from such logic system. This article aims to rearticulate the underlying lucid multi-dimensional logic system, which faded in obscurity only because of time-out loss of the mid-right concept. Retracing this past tacit but important concept could uncover a multi-dimensional system over a point relating to all matters while capturing the central core of the matter. The seemingly unmanageable multidimensional logic was strengthened by verification processes which affirmed its further extensions, and made up the language of the people, the concepts of yin-yang(阴阳), and the development of extensions of Ba Gua(八卦) derivatives, which furthered the interpretation of the space-time properties and Chinese medicine.展开更多
The solutions of the following bilinear stochastic differential equation are studied [GRAPHICS] where A(t)(k), B-t are (deterministic) continuous matrix-valued functions of t and w(1) (t),..., w(m) (t) are m independe...The solutions of the following bilinear stochastic differential equation are studied [GRAPHICS] where A(t)(k), B-t are (deterministic) continuous matrix-valued functions of t and w(1) (t),..., w(m) (t) are m independent standard Brownian motions. Conditions are given such that the solution is positive if the initial condition is positive. The equation the most probable path must satisfy is also derived and applied to a mathematical finance problem.展开更多
Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe_(2)-based anodes.Therefore,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial...Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe_(2)-based anodes.Therefore,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial for acquiring stable NiSe2-based materials for sodium-ion batteries(SIBs),Herein,a stress dissipation strategy driven by architecture engineering is proposed,which can achieve ultrafast and ultralong sodium storage properties.Different from the conventional sphere-like or rod-like architecture,the three-dimensional(3D)flower-like NiSe_(2)@C composite is delicately designed and assembled with onedimensional nanorods and carbon framework.More importantly,the fundamental mechanism of improved structure stability is unveiled by simulations and experimental results simultaneously.It demonstrates that this designed multidimensional flower-like architecture with dispersed nanorods can balance the structural mismatch,avoid concentrated local strain,and relax the internal stress,mainly induced by the unavoidable volume variation during the repeated conversion processes.Moreover,it can provide more Na^(+)-storage sites and multi-directional migration pathways,leading to a fast Na^(+)-migration channel with boosted reaction kinetic.As expected,it delivers superior rate performance(441 mA h g^(-1)at 5.0 A g^(-1))and long cycling stability(563 mA h g^(-1)at 1.0 A g^(-1)over 1000 cycles)for SIBs.This work provides useful insights for designing high-performance conversion-based anode materials for SIBs.展开更多
This paper explores whole-process engineering consulting,including its application models in public buildings and elderly-friendly projects,such as service integration and whole lifecycle management.It also addresses ...This paper explores whole-process engineering consulting,including its application models in public buildings and elderly-friendly projects,such as service integration and whole lifecycle management.It also addresses the construction of multi-dimensional collaborative theoretical models,public space streamline organization,and other aspects,emphasizing the importance of multi-dimensional collaboration.Additionally,it highlights the role of talent cultivation and digital transformation in enhancing project efficiency.展开更多
The multi-dimensional interactive teaching model significantly enhances the effectiveness of college English instruction by emphasizing dynamic engagement between teachers and students,as well as among students themse...The multi-dimensional interactive teaching model significantly enhances the effectiveness of college English instruction by emphasizing dynamic engagement between teachers and students,as well as among students themselves.This paper explores practical strategies for implementing this model,focusing on four key aspects:deepening teachers’understanding of the model through continuous learning,innovating interactive methods such as questioning techniques and practical activities,leveraging modern technology to integrate resources and track learning progress,and establishing a communication platform that centers on student participation.By adopting these approaches,the model fosters a student-centered classroom environment,improves comprehensive English application skills,and optimizes overall teaching quality.展开更多
During the critical transformation period of landscape architecture major after the adjustment of disciplinary structure and the changes in market demand,private colleges and universities,as important places for culti...During the critical transformation period of landscape architecture major after the adjustment of disciplinary structure and the changes in market demand,private colleges and universities,as important places for cultivating local talents,have pain points such as uneven quality of teachers and students and weak innovation and practice.The practice system with“multi-dimensional Integration”integrates four dimensions:interdisciplinary integration,spatial and temporal intersection,historical inheritance,and behavioral activity,deepens the disciplinary connotation,and integrates the three elements of nature,humanity,and technology,aiming to provide a new path for private colleges and universities to cultivate application-oriented and compound talents with innovative capabilities.In terms of optimizing talent cultivation and adapting to industry changes,this system provides thinking and reference for landscape architecture major,helping the major reshape its core competitiveness and promoting educational innovation and industry development.展开更多
This paper proposes a reliability evaluation model for a multi-dimensional network system,which has potential to be applied to the internet of things or other practical networks.A multi-dimensional network system with...This paper proposes a reliability evaluation model for a multi-dimensional network system,which has potential to be applied to the internet of things or other practical networks.A multi-dimensional network system with one source element and multiple sink elements is considered first.Each element can con-nect with other elements within a stochastic connection ranges.The system is regarded as successful as long as the source ele-ment remains connected with all sink elements.An importance measure is proposed to evaluate the performance of non-source elements.Furthermore,to calculate the system reliability and the element importance measure,a multi-valued decision diagram based approach is structured and its complexity is analyzed.Finally,a numerical example about the signal transfer station system is illustrated to analyze the system reliability and the ele-ment importance measure.展开更多
Constructing multi-dimensional hydrogen bond(H-bond)regulated single-molecule systems with multiemission remains a challenge.Herein,we report the design of a new excited-state intramolecular proton transfer(ESIPT)feat...Constructing multi-dimensional hydrogen bond(H-bond)regulated single-molecule systems with multiemission remains a challenge.Herein,we report the design of a new excited-state intramolecular proton transfer(ESIPT)featured chromophore(HBT-DPI)that shows flexible emission tunability via the multidimensional regulation of intra-and intermolecular H-bonds.The feature of switchable intramolecular Hbonds is induced via incorporating several hydrogen bond acceptors and donors into one single HBT-DPI molecule,allowing the“turn on/off”of ESIPT process by forming isomers with distinct intramolecular Hbonds configurations.In response to different external H-bonding environments,the obtained four types of crystal/cocrystals vary in the contents of isomers and the molecular packing modes,which are mainly guided by the intermolecular H-bonds,exhibiting non-emissive features or emissions ranging from green to orange.Utilizing the feature of intermolecular H-bond guided molecular packing,we demonstrate the utility of this fluorescent material for visualizing hydrophobic/hydrophilic areas on large-scale heterogeneous surfaces of modified poly(1,1-difluoroethylene)(PVDF)membranes and quantitatively estimating the surface hydrophobicity,providing a new approach for hydrophobicity/hydrophilicity monitoring and measurement.Overall,this study represents a new design strategy for constructing multi-dimensional hydrogen bond regulated ESIPT-based fluorescent materials that enable multiple emissions and unique applications.展开更多
To break the limitations of the multi-dimensional(M-D)vibration isolation(VI)platforms with the Stewart-Gough design,such as strongly coupling motions,excessive friction in connections,heavy weight,and limited workspa...To break the limitations of the multi-dimensional(M-D)vibration isolation(VI)platforms with the Stewart-Gough design,such as strongly coupling motions,excessive friction in connections,heavy weight,and limited workspace,this study processes a novel platform integrated by a stiffness-adjustable origami spring sub-structure and a parallel mechanism.The origami-based stiffness-adjustable spring realizes low-frequency VI,and the parallel mechanism symmetry design realizes motions decoupling.In the origami-based sub-leg,the parallel-stack-assembly(PSA)design mechanism with two Miura origami configurations is proposed to generate a symmetrical negative stiffness property.Paired with a linear positive stiffness spring,the origami-based sub-leg has wide-amplitude-high-static-low-dynamic stiffness(WA-HSLDS)characteristics in one direction.Then,with construction of the parallel mechanism connected with origami-based sub-legs,an M-D VI platform is achieved,whose motions in the vertical direction and yaw direction are decoupled with the motions in the other directions.Based on the dynamic model and incremental harmonic balance(IHB)with the arc-length continuation method,appropriate structural parameters in the parallel mechanism part are figured out,and the accurate transmissibility in different directions is defined,which gives the parametric influencing investigations for realization of low-frequency VI performances.Finally,experiments are conducted to validate the accuracy and feasibility of the theoretical methods,and to demonstrate the performance of M-D low-frequency isolation with load-carrying capacity of the proposed VI platform.The integration of the origami into the parallel mechanism results in a compact,efficient,and flexible platform with nonlinear adjustability,offering new possibilities for lightweight M-D VI,and developing the practical applications in high-precision platforms in ocean and aerospace environments.展开更多
Gauss radial basis functions(GRBF)are frequently employed in data fitting and machine learning.Their linear independence property can theoretically guarantee the avoidance of data redundancy.In this paper,one of the m...Gauss radial basis functions(GRBF)are frequently employed in data fitting and machine learning.Their linear independence property can theoretically guarantee the avoidance of data redundancy.In this paper,one of the main contributions is proving this property using linear algebra instead of profound knowledge.This makes it easy to read and understand this fundamental fact.The proof of linear independence of a set of Gauss functions relies on the constructing method for one-dimensional space and on the deducing method for higher dimensions.Additionally,under the condition of preserving the same moments between the original function and interpolating function,both the interpolating existence and uniqueness are proven for GRBF in one-dimensional space.The final work demonstrates the application of the GRBF method to locate lunar olivine.By combining preprocessed data using GRBF with the removing envelope curve method,a program is created to find the position of lunar olivine based on spectrum data,and the numerical experiment shows that it is an effective scheme.展开更多
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s...Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury.展开更多
In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov ...In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov processes,non-stationary signals,and other mathematical disciplines.The aim of the current research article is to first improve the bounds of coefficient-related problems by employing the well-known Carathéodory function.The problems that we are going to improve were obtained by Tang et al.The sharp estimates of the most difficult problem of geometric function theory known as the third-order Hankel determinant are also contributed here.Zalcman and Fekete-Szegöinequalities are also studied here for the defined family of holomorphic functions.展开更多
Functional gastrointestinal disorders(FGIDs),including irritable bowel syndrome(IBS),functional dyspepsia(FD),and gastroesophageal reflux disease(GERD),present persistent diagnostic and therapeutic challenges due to s...Functional gastrointestinal disorders(FGIDs),including irritable bowel syndrome(IBS),functional dyspepsia(FD),and gastroesophageal reflux disease(GERD),present persistent diagnostic and therapeutic challenges due to symptom heterogeneity and the absence of reliable biomarkers.Artificial intelligence(AI)enables the integration of multimodal data to enhance FGID management through precision diagnostics and preventive healthcare.This minireview summarizes recent advancements in AI applications for FGIDs,highlighting progress in diagnostic accuracy,subtype classification,personalized interventions,and preventive strategies inspired by the traditional Chinese medicine concept of“treating the undiseased”.Machine learning and deep learning algorithms have demonstrated value in improving IBS diagnosis,refining FD neuro-gastrointestinal subtyping,and screening for GERD-related complications.Moreover,AI supports dietary,psychological,and integrative medicine-based interventions to improve patient adherence and quality of life.Nonetheless,key challenges remain,including data heterogeneity,limited model interpretability,and the need for robust clinical validation.Future directions emphasize interdisciplinary collaboration,the development of multimodal and explainable AI models,and the creation of patientcentered platforms to facilitate a shift from reactive treatment to proactive prevention.This review provides a systematic framework to guide the clinical application and theoretical innovation of AI in FGIDs.展开更多
Aspergillus species are ubiquitous fungi that produce mycotoxins(secondary metabolites)known as sterigmatocystin and aflatoxins in many different kinds of foods,which leads to serious contamination in agricultural pro...Aspergillus species are ubiquitous fungi that produce mycotoxins(secondary metabolites)known as sterigmatocystin and aflatoxins in many different kinds of foods,which leads to serious contamination in agricultural products,thereby endangering human health.Extensive studies on Aspergillus fungi have been conducted on growth and development,aflatoxin biosynthesis,and their interactions with environment.Here,we summarized a series of functional genes of the main Aspergillus fungi relative to toxins occurrence in foods,which revealed the signal transduction mechanisms of their involvement in growth and development,toxin production,and response to light,anticipating providing theoretical guidance on developing control and prevention technologies for mycotoxin contamination in agricultural products to ensure food safety.展开更多
Given the broad applicability of carbazole structural moieties in materials science and medicinal chemistry,significant efforts have been devoted to developing efficient synthetic catalytic methodologies to access thi...Given the broad applicability of carbazole structural moieties in materials science and medicinal chemistry,significant efforts have been devoted to developing efficient synthetic catalytic methodologies to access this valuable scaffold.Catalyzed direct Csp^(2)-H functionalization provides an effective and costefficient approach to synthesizing carbazoles from simple and readily available starting materials,ensuring a promising path characterized by excellent atom and step economy.This review highlights the substantial progress made in the last 10 years in advancing catalytic Csp^(2)-H functionalization techniques for synthesizing carbazoles.展开更多
BACKGROUND An echocardiogram is an essential tool in the evaluation of potential kidney transplant recipients(KTRs).Despite cardiac clearance,potential KTRs still have structural and functional abnormalities.Identifyi...BACKGROUND An echocardiogram is an essential tool in the evaluation of potential kidney transplant recipients(KTRs).Despite cardiac clearance,potential KTRs still have structural and functional abnormalities.Identifying the prevalence of these abnormalities and understanding their predictors is vital for optimizing pretransplant risk stratification and improving post-transplant outcomes.AIM To determine the prevalence of left ventricular hypertrophy(LVH),left ventricular systolic dysfunction(LVSD),diastolic dysfunction(DD),pulmonary hypertension(PH),and their predictors,and to assess their impact on graft function in pre-transplant candidates.METHODS The study included all successful transplant candidates older than 14 who had a baseline echocardiogram.Binary logistic regression models were constructed to identify factors associated with LVH,LVSD,DD,and PH.RESULTS Out of 259 patients,LVH was present in 64%(166),12%(31)had LVSD,27.5%(71)had DD,and 66(25.5%)had PH.Independent predictors of LVH included male gender[odds ratio(OR):2.51;95%CI:1.17-5.41 P=0.02],PH(OR=2.07;95%CI:1.11-3.86;P=0.02),DD(OR:2.47;95%CI:1.29-4.73;P=0.006),and dyslipidemia(OR=1.94;95%CI:1.07-3.53;P=0.03).Predictors for LVSD included patients with DD(OR=3.3,95%CI:1.41-7.81;P=0.006)and a family history of coronary artery disease(OR=4.50,95%CI:1.33-15.20;P=0.015).Peritoneal dialysis was an independent predictor for DD(OR=10.03;95%CI:1.71-58.94,P=0.011).The presence of LVH(OR=3.32,95%CI:1.05-10.55,P=0.04)and mild to moderate or moderate to severe mitral regurgitation(OR=4.63,95%CI:1.45-14.78,P=0.01)were significant factors associated with PH.These abnormalities had no significant impact on estimated glomerular filtration at discharge,6 months,1 year,or 2 years post-transplant.CONCLUSION Significant echocardiographic abnormalities persist in a potential transplant candidate despite cardiac clearance,although they don’t affect future graft function.Understanding the risk factors associated with these abnormalities may help clinicians address these factors pre-and post-transplant to achieve better outcomes.展开更多
[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD...[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD)based on network pharmacology.[Methods]Firstly,we reviewed the existing research progress on each constituent drug of the Jineijin Shanzha Patch for FD improvement.Following this,identified overlapping genes were utilized to construct both a"Drug-Active Component-FD Target"network and a Protein-Protein Interaction(PPI)network specific to the patch.In addition,Gene Ontology(GO)analysis was carried out.[Results]We identified that the 13 herbs in the Jineijin Shanzha Patch are mainly used for food stagnation,qi stagnation,and spleen deficiency.Screening revealed 43 active patch components,1414 FD-related targets,and 284 shared targets between them.The PPI network analysis further identified the top 10 core targets from these shared targets.From the"Drug-Active Component-FD Target"network,we identified the core elements.These included the herbal components Vignae Semen(from Liushenqu),Crataegi Fructus,and Pseudostellariae Radix;the active components quercetin,genistein,and apigenin;and the key targets CASP3,BCL2,and CASP9.GO analysis of the 284 overlapping targets indicated that the Jineijin Shanzha Patch may exert its therapeutic effects via regulation of biological processes such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway.[Conclusions]The main active components of the Jineijin Shanzha Patch(quercetin,genistein,and apigenin)may improve FD by modulating signaling pathways such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway,thereby acting on key targets including CASP3,BCL2,and CASP9.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.62422503,62105080,22004016,and U22A2093)the Guangdong Basic and Applied Basic Research Foundation Regional Joint Fund(Grant Nos.2023A1515011944,2020B1515130006,and 2021B515120056)+1 种基金the Talent Recruitment Project of Guangdong(Grant No.2021QN02X179)the Science and Technology Innovation Commission of Shenzhen(Grant Nos.JCYJ20220531095604009 and RCYX20221008092907027).
文摘Confronting the escalating global challenge of counterfeit products,developing advanced anticounterfeiting materials and structures with physical unclonable functions(PUFs)has become imperative.All-optical PUFs,distinguished by their high output complexity and expansive response space,offer a promising alternative to conventional electronic counterparts.For practical authentications,the expansion of optical PUF keys usually involves intricate spatial or spectral shaping of excitation light using bulky external apparatus,which largely hinders the applications of optical PUFs.Here,we report a plasmonic PUF system based on heterogeneous nanostructures.The template-assisted shadow deposition technique was employed to adjust the morphological diversity of densely packed metal nanoparticles in individual PUFs.Transmission images were processed via a hash algorithm,and the generated PUF keys with a scalable capacity from 2875 to 243401 exhibit excellent uniqueness,randomness,and reproducibility.Furthermore,the wavelength and the polarization state of the excitation light are harnessed as two distinct expanding strategies,offering the potential for multiscenario applications via a single PUF.Overall,our reported plasmonic PUFs operated with the multidimensional expanding strategy are envisaged to serve as easy-to-integrate,easy-to-use systems and promise efficacy across a broad spectrum of applications,from anticounterfeiting to data encryption and authentication.
基金co-supported by the National Key R&D Program of China(No.2023YFB4704400)the Zhejiang Provincial Natural Science Foundation of China(No.LQ24F030012)the National Natural Science Foundation of China General Project(No.62373033)。
文摘A composite anti-disturbance predictive control strategy employing a Multi-dimensional Taylor Network(MTN)is presented for unmanned systems subject to time-delay and multi-source disturbances.First,the multi-source disturbances are addressed according to their specific characteristics as follows:(A)an MTN data-driven model,which is used for uncertainty description,is designed accompanied with the mechanism model to represent the unmanned systems;(B)an adaptive MTN filter is used to remove the influence of the internal disturbance;(C)an MTN disturbance observer is constructed to estimate and compensate for the influence of the external disturbance;(D)the Extended Kalman Filter(EKF)algorithm is utilized as the learning mechanism for MTNs.Second,to address the time-delay effect,a recursiveτstep-ahead MTN predictive model is designed utilizing recursive technology,aiming to mitigate the impact of time-delay,and the EKF algorithm is employed as its learning mechanism.Then,the MTN predictive control law is designed based on the quadratic performance index.By implementing the proposed composite controller to unmanned systems,simultaneous feedforward compensation and feedback suppression to the multi-source disturbances are conducted.Finally,the convergence of the MTN and the stability of the closed-loop system are established utilizing the Lyapunov theorem.Two exemplary applications of unmanned systems involving unmanned vehicle and rigid spacecraft are presented to validate the effectiveness of the proposed approach.
基金supported by the National Key Research and Development Program of China(2016YFE0200400)the Key R&D Program of Shaanxi Province(2017KW-ZD-12)+1 种基金the Postdoctoral Science Foundation of Shaanxi Provincethe Nature Science Foundation of Shaanxi Province
文摘Space-time coding radar has been recently proposed and investigated.It is a radar framework which can perform transmit beamforming at the receiver.However,the range resolution decreases when the number of the transmit element increases.A subarray-based space-time coding(sub-STC)radar is explored to alleviate the range resolution reduction.For the proposed radar configuration,an identical waveform is transmitted and it introduces a small time offset in different subarrays.The multidimensional ambiguity function of sub-STC radar is defined by considering resolutions in multiple domains including the range,Doppler,angle and probing direction.Analyses on properties of the multi-dimensional ambiguity function of the sub-STC radar with regard to the spatial coverage,resolution performance and low sidelobes are also given.Results reveal that the range resolution and low sidelobes performance are improved with the proposed approach.
文摘The ancient tacit knowledge behind the logic system permeated the culture and promoted numerous impactful inventions throughout the history. Traditional Chinese medicine with its effectiveness should also have stemmed out from such logic system. This article aims to rearticulate the underlying lucid multi-dimensional logic system, which faded in obscurity only because of time-out loss of the mid-right concept. Retracing this past tacit but important concept could uncover a multi-dimensional system over a point relating to all matters while capturing the central core of the matter. The seemingly unmanageable multidimensional logic was strengthened by verification processes which affirmed its further extensions, and made up the language of the people, the concepts of yin-yang(阴阳), and the development of extensions of Ba Gua(八卦) derivatives, which furthered the interpretation of the space-time properties and Chinese medicine.
基金the General Research Fund of the University of Kansas.
文摘The solutions of the following bilinear stochastic differential equation are studied [GRAPHICS] where A(t)(k), B-t are (deterministic) continuous matrix-valued functions of t and w(1) (t),..., w(m) (t) are m independent standard Brownian motions. Conditions are given such that the solution is positive if the initial condition is positive. The equation the most probable path must satisfy is also derived and applied to a mathematical finance problem.
基金the financial support from the Guangxi Natural Science Foundation(grant no.2021GXNSFDA075012,2023GXNSFGA026002)National Natural Science Foundation of China(52104298,22075073,52362027,52462029)Fundamental Research Funds for the Central Universities(531107051077).
文摘Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe_(2)-based anodes.Therefore,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial for acquiring stable NiSe2-based materials for sodium-ion batteries(SIBs),Herein,a stress dissipation strategy driven by architecture engineering is proposed,which can achieve ultrafast and ultralong sodium storage properties.Different from the conventional sphere-like or rod-like architecture,the three-dimensional(3D)flower-like NiSe_(2)@C composite is delicately designed and assembled with onedimensional nanorods and carbon framework.More importantly,the fundamental mechanism of improved structure stability is unveiled by simulations and experimental results simultaneously.It demonstrates that this designed multidimensional flower-like architecture with dispersed nanorods can balance the structural mismatch,avoid concentrated local strain,and relax the internal stress,mainly induced by the unavoidable volume variation during the repeated conversion processes.Moreover,it can provide more Na^(+)-storage sites and multi-directional migration pathways,leading to a fast Na^(+)-migration channel with boosted reaction kinetic.As expected,it delivers superior rate performance(441 mA h g^(-1)at 5.0 A g^(-1))and long cycling stability(563 mA h g^(-1)at 1.0 A g^(-1)over 1000 cycles)for SIBs.This work provides useful insights for designing high-performance conversion-based anode materials for SIBs.
文摘This paper explores whole-process engineering consulting,including its application models in public buildings and elderly-friendly projects,such as service integration and whole lifecycle management.It also addresses the construction of multi-dimensional collaborative theoretical models,public space streamline organization,and other aspects,emphasizing the importance of multi-dimensional collaboration.Additionally,it highlights the role of talent cultivation and digital transformation in enhancing project efficiency.
文摘The multi-dimensional interactive teaching model significantly enhances the effectiveness of college English instruction by emphasizing dynamic engagement between teachers and students,as well as among students themselves.This paper explores practical strategies for implementing this model,focusing on four key aspects:deepening teachers’understanding of the model through continuous learning,innovating interactive methods such as questioning techniques and practical activities,leveraging modern technology to integrate resources and track learning progress,and establishing a communication platform that centers on student participation.By adopting these approaches,the model fosters a student-centered classroom environment,improves comprehensive English application skills,and optimizes overall teaching quality.
基金Sponsored by the Quality Engineering Project of Education Department of Anhui Province(2022jyxm671)Research Team Project of Anhui Xinhua University(kytd202202)+1 种基金Key Project of Scientific Research(Natural Science)of Higher Education Institutions in Anhui Province(2022AH051861)Teaching Reform Research and Practice Quality Engineering Project of Anhui Xinhua University(2024jy035).
文摘During the critical transformation period of landscape architecture major after the adjustment of disciplinary structure and the changes in market demand,private colleges and universities,as important places for cultivating local talents,have pain points such as uneven quality of teachers and students and weak innovation and practice.The practice system with“multi-dimensional Integration”integrates four dimensions:interdisciplinary integration,spatial and temporal intersection,historical inheritance,and behavioral activity,deepens the disciplinary connotation,and integrates the three elements of nature,humanity,and technology,aiming to provide a new path for private colleges and universities to cultivate application-oriented and compound talents with innovative capabilities.In terms of optimizing talent cultivation and adapting to industry changes,this system provides thinking and reference for landscape architecture major,helping the major reshape its core competitiveness and promoting educational innovation and industry development.
基金supported by the National Natural Science Foundation of China(72101025,72271049),the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities,FRF-IDRY-24-024)the Hebei Natural Science Foundation(F2023501011)+1 种基金the Fundamental Research Funds for the Central Universities(FRF-TP-20-073A1)the R&D Program of Beijing Municipal Education Commission(KM202411232015).
文摘This paper proposes a reliability evaluation model for a multi-dimensional network system,which has potential to be applied to the internet of things or other practical networks.A multi-dimensional network system with one source element and multiple sink elements is considered first.Each element can con-nect with other elements within a stochastic connection ranges.The system is regarded as successful as long as the source ele-ment remains connected with all sink elements.An importance measure is proposed to evaluate the performance of non-source elements.Furthermore,to calculate the system reliability and the element importance measure,a multi-valued decision diagram based approach is structured and its complexity is analyzed.Finally,a numerical example about the signal transfer station system is illustrated to analyze the system reliability and the ele-ment importance measure.
基金supported by the National Key R&D Program of China(No.2021YFC2103600)the National Natural Science Foundation of China(Nos.21878156,21978131,22275085,and 22278224)+2 种基金the Natural Science Foundation of Jiangsu Province(Nos.BK20200089 and BK20200691)the Project of Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the State Key Laboratory of Materials-Oriented Chemical Engineering(No.KL21-08).
文摘Constructing multi-dimensional hydrogen bond(H-bond)regulated single-molecule systems with multiemission remains a challenge.Herein,we report the design of a new excited-state intramolecular proton transfer(ESIPT)featured chromophore(HBT-DPI)that shows flexible emission tunability via the multidimensional regulation of intra-and intermolecular H-bonds.The feature of switchable intramolecular Hbonds is induced via incorporating several hydrogen bond acceptors and donors into one single HBT-DPI molecule,allowing the“turn on/off”of ESIPT process by forming isomers with distinct intramolecular Hbonds configurations.In response to different external H-bonding environments,the obtained four types of crystal/cocrystals vary in the contents of isomers and the molecular packing modes,which are mainly guided by the intermolecular H-bonds,exhibiting non-emissive features or emissions ranging from green to orange.Utilizing the feature of intermolecular H-bond guided molecular packing,we demonstrate the utility of this fluorescent material for visualizing hydrophobic/hydrophilic areas on large-scale heterogeneous surfaces of modified poly(1,1-difluoroethylene)(PVDF)membranes and quantitatively estimating the surface hydrophobicity,providing a new approach for hydrophobicity/hydrophilicity monitoring and measurement.Overall,this study represents a new design strategy for constructing multi-dimensional hydrogen bond regulated ESIPT-based fluorescent materials that enable multiple emissions and unique applications.
基金Project supported by the National Natural Science Foundation of China(Nos.U2441202,12372043,and 12372022)the Fundamental Research Funds for Central Universities。
文摘To break the limitations of the multi-dimensional(M-D)vibration isolation(VI)platforms with the Stewart-Gough design,such as strongly coupling motions,excessive friction in connections,heavy weight,and limited workspace,this study processes a novel platform integrated by a stiffness-adjustable origami spring sub-structure and a parallel mechanism.The origami-based stiffness-adjustable spring realizes low-frequency VI,and the parallel mechanism symmetry design realizes motions decoupling.In the origami-based sub-leg,the parallel-stack-assembly(PSA)design mechanism with two Miura origami configurations is proposed to generate a symmetrical negative stiffness property.Paired with a linear positive stiffness spring,the origami-based sub-leg has wide-amplitude-high-static-low-dynamic stiffness(WA-HSLDS)characteristics in one direction.Then,with construction of the parallel mechanism connected with origami-based sub-legs,an M-D VI platform is achieved,whose motions in the vertical direction and yaw direction are decoupled with the motions in the other directions.Based on the dynamic model and incremental harmonic balance(IHB)with the arc-length continuation method,appropriate structural parameters in the parallel mechanism part are figured out,and the accurate transmissibility in different directions is defined,which gives the parametric influencing investigations for realization of low-frequency VI performances.Finally,experiments are conducted to validate the accuracy and feasibility of the theoretical methods,and to demonstrate the performance of M-D low-frequency isolation with load-carrying capacity of the proposed VI platform.The integration of the origami into the parallel mechanism results in a compact,efficient,and flexible platform with nonlinear adjustability,offering new possibilities for lightweight M-D VI,and developing the practical applications in high-precision platforms in ocean and aerospace environments.
基金Supported by the National Basic Research Program of China(2012CB025904)Zhengzhou Shengda University of Economics,Business and Management(SD-YB2025085)。
文摘Gauss radial basis functions(GRBF)are frequently employed in data fitting and machine learning.Their linear independence property can theoretically guarantee the avoidance of data redundancy.In this paper,one of the main contributions is proving this property using linear algebra instead of profound knowledge.This makes it easy to read and understand this fundamental fact.The proof of linear independence of a set of Gauss functions relies on the constructing method for one-dimensional space and on the deducing method for higher dimensions.Additionally,under the condition of preserving the same moments between the original function and interpolating function,both the interpolating existence and uniqueness are proven for GRBF in one-dimensional space.The final work demonstrates the application of the GRBF method to locate lunar olivine.By combining preprocessed data using GRBF with the removing envelope curve method,a program is created to find the position of lunar olivine based on spectrum data,and the numerical experiment shows that it is an effective scheme.
基金supported by the National Natural Science Foundation of China,Nos.82072165 and 82272256(both to XM)the Key Project of Xiangyang Central Hospital,No.2023YZ03(to RM)。
文摘Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury.
基金supported by the NSFC(11561001)the Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT18-A14)+4 种基金the NSF of Inner Mongolia(2022MS01004,2020MS01011)the Higher School Foundation of Inner Mongolia(NJZY20200)the Program for Key Laboratory Construction of Chifeng University(CFXYZD202004)the Research and Innovation Team of Complex Analysis and Nonlinear Dynamic Systems of Chifeng University(cfxykycxtd202005)the Youth Science Foundation of Chifeng University(cfxyqn202133).
文摘In recent years,researchers have extensively investigated the Hankel determinant,which consists of coefficients appearing in a holomorphic function’s Taylor-Maclaurin series.Hankel matrices are widely used in Markov processes,non-stationary signals,and other mathematical disciplines.The aim of the current research article is to first improve the bounds of coefficient-related problems by employing the well-known Carathéodory function.The problems that we are going to improve were obtained by Tang et al.The sharp estimates of the most difficult problem of geometric function theory known as the third-order Hankel determinant are also contributed here.Zalcman and Fekete-Szegöinequalities are also studied here for the defined family of holomorphic functions.
基金Supported by The Natural Science Foundation of China,No.82374292the Plans for Major Provincial Science and Technology Projects of Anhui Province,No.202303a07020003the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine,No.ZYYCXTD-C-202401.
文摘Functional gastrointestinal disorders(FGIDs),including irritable bowel syndrome(IBS),functional dyspepsia(FD),and gastroesophageal reflux disease(GERD),present persistent diagnostic and therapeutic challenges due to symptom heterogeneity and the absence of reliable biomarkers.Artificial intelligence(AI)enables the integration of multimodal data to enhance FGID management through precision diagnostics and preventive healthcare.This minireview summarizes recent advancements in AI applications for FGIDs,highlighting progress in diagnostic accuracy,subtype classification,personalized interventions,and preventive strategies inspired by the traditional Chinese medicine concept of“treating the undiseased”.Machine learning and deep learning algorithms have demonstrated value in improving IBS diagnosis,refining FD neuro-gastrointestinal subtyping,and screening for GERD-related complications.Moreover,AI supports dietary,psychological,and integrative medicine-based interventions to improve patient adherence and quality of life.Nonetheless,key challenges remain,including data heterogeneity,limited model interpretability,and the need for robust clinical validation.Future directions emphasize interdisciplinary collaboration,the development of multimodal and explainable AI models,and the creation of patientcentered platforms to facilitate a shift from reactive treatment to proactive prevention.This review provides a systematic framework to guide the clinical application and theoretical innovation of AI in FGIDs.
基金supported by the key project of National Natural Sciences Foundation of China(U22A20551,32030085)the Major Project of Hubei Hongshan Laboratory,China(2021hszd015)+2 种基金the Hubei Province Major Science and Technology Special Project,China(2023BBA002)the National Natural Sciences Foundation of China(U22A20551)the National Natural Science Foundation of China Excellent Youth Fund(32422072)。
文摘Aspergillus species are ubiquitous fungi that produce mycotoxins(secondary metabolites)known as sterigmatocystin and aflatoxins in many different kinds of foods,which leads to serious contamination in agricultural products,thereby endangering human health.Extensive studies on Aspergillus fungi have been conducted on growth and development,aflatoxin biosynthesis,and their interactions with environment.Here,we summarized a series of functional genes of the main Aspergillus fungi relative to toxins occurrence in foods,which revealed the signal transduction mechanisms of their involvement in growth and development,toxin production,and response to light,anticipating providing theoretical guidance on developing control and prevention technologies for mycotoxin contamination in agricultural products to ensure food safety.
基金support and funding by the European Union-Next Generation EU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem (No.ECS00000041-VITALITY and also “Ecosistema TECH4YOU-(Spoke 3-Goal 3.5)MUR is thanked for PRIN-PNRR 2022 project "P2022XKWH7-Circular Waste+3 种基金The University of Perugia is acknowledged for financial support to the university project “Fondo Ricerca di Ateneo,edizione 2022”The National Ph D program in Catalysis coordinated by the University of Perugia is also thankedthe financial supports of key research and development and technology transfer projects of Inner Mongolia Autonomous Region (No.2025KJHZ0008)major special projects of science and technology of Ordos (No.2022EEDSKJZDZX003)。
文摘Given the broad applicability of carbazole structural moieties in materials science and medicinal chemistry,significant efforts have been devoted to developing efficient synthetic catalytic methodologies to access this valuable scaffold.Catalyzed direct Csp^(2)-H functionalization provides an effective and costefficient approach to synthesizing carbazoles from simple and readily available starting materials,ensuring a promising path characterized by excellent atom and step economy.This review highlights the substantial progress made in the last 10 years in advancing catalytic Csp^(2)-H functionalization techniques for synthesizing carbazoles.
文摘BACKGROUND An echocardiogram is an essential tool in the evaluation of potential kidney transplant recipients(KTRs).Despite cardiac clearance,potential KTRs still have structural and functional abnormalities.Identifying the prevalence of these abnormalities and understanding their predictors is vital for optimizing pretransplant risk stratification and improving post-transplant outcomes.AIM To determine the prevalence of left ventricular hypertrophy(LVH),left ventricular systolic dysfunction(LVSD),diastolic dysfunction(DD),pulmonary hypertension(PH),and their predictors,and to assess their impact on graft function in pre-transplant candidates.METHODS The study included all successful transplant candidates older than 14 who had a baseline echocardiogram.Binary logistic regression models were constructed to identify factors associated with LVH,LVSD,DD,and PH.RESULTS Out of 259 patients,LVH was present in 64%(166),12%(31)had LVSD,27.5%(71)had DD,and 66(25.5%)had PH.Independent predictors of LVH included male gender[odds ratio(OR):2.51;95%CI:1.17-5.41 P=0.02],PH(OR=2.07;95%CI:1.11-3.86;P=0.02),DD(OR:2.47;95%CI:1.29-4.73;P=0.006),and dyslipidemia(OR=1.94;95%CI:1.07-3.53;P=0.03).Predictors for LVSD included patients with DD(OR=3.3,95%CI:1.41-7.81;P=0.006)and a family history of coronary artery disease(OR=4.50,95%CI:1.33-15.20;P=0.015).Peritoneal dialysis was an independent predictor for DD(OR=10.03;95%CI:1.71-58.94,P=0.011).The presence of LVH(OR=3.32,95%CI:1.05-10.55,P=0.04)and mild to moderate or moderate to severe mitral regurgitation(OR=4.63,95%CI:1.45-14.78,P=0.01)were significant factors associated with PH.These abnormalities had no significant impact on estimated glomerular filtration at discharge,6 months,1 year,or 2 years post-transplant.CONCLUSION Significant echocardiographic abnormalities persist in a potential transplant candidate despite cardiac clearance,although they don’t affect future graft function.Understanding the risk factors associated with these abnormalities may help clinicians address these factors pre-and post-transplant to achieve better outcomes.
基金Supported by Putuo District Science and Technology R&D Platform Project,Shanghai(2024QX04).
文摘[Objectives]To investigate the efficacy and potential mechanism of the topical preparation Jineijin-Shanzha Patch(composed of Galli Gigerii Endothelium Corneum and Crataegi Fructus)in improving functional dyspepsia(FD)based on network pharmacology.[Methods]Firstly,we reviewed the existing research progress on each constituent drug of the Jineijin Shanzha Patch for FD improvement.Following this,identified overlapping genes were utilized to construct both a"Drug-Active Component-FD Target"network and a Protein-Protein Interaction(PPI)network specific to the patch.In addition,Gene Ontology(GO)analysis was carried out.[Results]We identified that the 13 herbs in the Jineijin Shanzha Patch are mainly used for food stagnation,qi stagnation,and spleen deficiency.Screening revealed 43 active patch components,1414 FD-related targets,and 284 shared targets between them.The PPI network analysis further identified the top 10 core targets from these shared targets.From the"Drug-Active Component-FD Target"network,we identified the core elements.These included the herbal components Vignae Semen(from Liushenqu),Crataegi Fructus,and Pseudostellariae Radix;the active components quercetin,genistein,and apigenin;and the key targets CASP3,BCL2,and CASP9.GO analysis of the 284 overlapping targets indicated that the Jineijin Shanzha Patch may exert its therapeutic effects via regulation of biological processes such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway.[Conclusions]The main active components of the Jineijin Shanzha Patch(quercetin,genistein,and apigenin)may improve FD by modulating signaling pathways such as the response to lipopolysaccharide,response to bacterium-derived molecules,and regulation of the apoptotic signaling pathway,thereby acting on key targets including CASP3,BCL2,and CASP9.
