Naturally degradable capsule provides a platform for sustained fragrance release.However,practical challenges such as low encapsulation efficiency and difficulty in sustained release are still limited in using fragran...Naturally degradable capsule provides a platform for sustained fragrance release.However,practical challenges such as low encapsulation efficiency and difficulty in sustained release are still limited in using fragranceloaded capsules.In this work,the natural materials sodium alginate and gelatine are dissolved and act as the aqueous phase,lavender is dissolved in caprylic/capric triglyceride(GTCC)as the oil phase,and SiO_(2) nanoparticles with neutralwettability as a solid emulsifier to form O/W Pickering emulsions simultaneously.Finally,multi-core capsules are prepared using the drop injection method with emulsions as templates.The results show that the capsules have been successfully prepared with a spherical morphology and multi-core structure,and the encapsulation rate of multi-core capsules can reach up to 99.6%.In addition,the multi-core capsules possess desirable sustained release performance,the cumulative sustained release rate of fragrance at 25℃over 49 days is only 32.5%.It is attributed to the significant protection of multi-core structure,Pickering emulsion nanoparticle membranes,and hydrogel network shell for encapsulated fragrance.This study is designed to deliver a new strategy for using sustained-release technology with fragrance in food,cosmetics,textiles,and other fields.展开更多
Online programming platforms are popular in programming education.However,there has been no research investigating students’real opinions and expectations of the error feedback mechanisms,leaving educators without a ...Online programming platforms are popular in programming education.However,there has been no research investigating students’real opinions and expectations of the error feedback mechanisms,leaving educators without a solid data foundation when attempting to improve the error feedback mechanisms.This paper makes a survey of 834 students across various programming courses and investigates student perceptions of error feedback mechanisms on online programming platforms.It explores the effectiveness of existing feedback,student satisfaction,and preferences for potential improvements,focusing on automatic error localization and program repair mechanisms.Results reveal a significant portion of students are dissatisfied with current feedback due to its limited informativeness.Students also express a clear demand for stronger feedback mechanisms,such as error localization and repair hints.Nevertheless,they prefer feedback that subtly guides them toward solutions,rather than providing direct and explicit answers,valuing the opportunity to enhance their debugging skills.The findings suggest a need for balanced,educational-focused feedback mechanisms that aid learning while promoting independent problem-solving.展开更多
Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disruptin...Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons.展开更多
In this paper,we study a class of Linear Fractional Programming on a nonempty bounded set,called the Problem(LFP),and design a branch and bound algorithm to find the global optimal solution of the problem(LFP).First,w...In this paper,we study a class of Linear Fractional Programming on a nonempty bounded set,called the Problem(LFP),and design a branch and bound algorithm to find the global optimal solution of the problem(LFP).First,we convert the problem(LFP)to the equivalent problem(EP2).Secondly,by applying the linear relaxation technique to the problem(EP2),the linear relaxation programming problem(LRP2Y)was obtained.Then,the overall framework of the algorithm is given,and the convergence and complexity of the algorithm are analyzed.Finally,experimental results are listed to illustrate the effectiveness of the algorithm.展开更多
Aiming at the problem of innovative talent training in the industry field in characteristic software colleges,combined with the actual situation of Software College of Northeastern University,this paper analyzes the c...Aiming at the problem of innovative talent training in the industry field in characteristic software colleges,combined with the actual situation of Software College of Northeastern University,this paper analyzes the construction requirements of characteristic talent training mode and training scheme,puts forward the reform of characteristic software innovative talent training scheme integrating production and education,and takes the characteristic direction of financial technology as an example to introduce the curriculum construction based on industry-education integration and school-enterprise cooperation.展开更多
The field of nanomedicine has been revolutionized by the concept of immunogenic cell death(ICD)-enhanced cancer therapy,which holds immense promise for the efficient treatment of cancer.However,precise delivery of ICD...The field of nanomedicine has been revolutionized by the concept of immunogenic cell death(ICD)-enhanced cancer therapy,which holds immense promise for the efficient treatment of cancer.However,precise delivery of ICD inducer is severely hindered by complex biological barriers.How to design and build intelligent nanoplatform for adaptive and dynamic cancer therapy remains a big challenge.Herein,this article presents the design and preparation of CD44-targeting and ZIF-8 gated gold nanocage(Au@ZH) for programmed delivery of the 1,2-diaminocyclohexane-Pt(Ⅱ)(DACHPt) as ICD inducer.After actively targeting the CD44 on the surface of 4T1 tumor cell,this Pt-Au@ZH can be effectively endocytosed by the 4T1 cell and release the DACHPt in tumor acidic environment,resulting in ICD effect and superior antitumor efficacy both in vitro and in vivo in the presence of mild 808 nm laser irradiation.By integration of internal and external stimuli intelligently,this programmed nanoplatform is poised to become a cornerstone in the pursuit of effective and targeted cancer therapy in the foreseeable future.展开更多
During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive...During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive distance)to a moving target as quickly as possible,resulting in the extended minimum-time intercept problem(EMTIP).Existing research has primarily focused on the zero-distance intercept problem,MTIP,establishing the necessary or sufficient conditions for MTIP optimality,and utilizing analytic algorithms,such as root-finding algorithms,to calculate the optimal solutions.However,these approaches depend heavily on the properties of the analytic algorithm,making them inapplicable when problem settings change,such as in the case of a positive effective range or complicated target motions outside uniform rectilinear motion.In this study,an approach employing a high-accuracy and quality-guaranteed mixed-integer piecewise-linear program(QG-PWL)is proposed for the EMTIP.This program can accommodate different effective interception ranges and complicated target motions(variable velocity or complicated trajectories).The high accuracy and quality guarantees of QG-PWL originate from elegant strategies such as piecewise linearization and other developed operation strategies.The approximate error in the intercept path length is proved to be bounded to h^(2)/(4√2),where h is the piecewise length.展开更多
A novel kind of multi-core magnetic composite particles, the surfaces of which were respectively mo- dified with goat-anti-mouse IgG and antitransferrin receptor（anti-CD71）, was prepared. The fetal nucleated red blo...A novel kind of multi-core magnetic composite particles, the surfaces of which were respectively mo- dified with goat-anti-mouse IgG and antitransferrin receptor（anti-CD71）, was prepared. The fetal nucleated red blood cells（FNRBCs） in the peripheral blood of a gravida were rapidly and effectively enriched and separated by the mo- dified multi-core magnetic composite particles in an external magnetic field. The obtained FNRBCs were used for the identification of the fetal sex by means of fluorescence in situ hybridization（FISH） technique. The results demonstrate that the multi-core magnetic composite particles meet the requirements for the enrichment and speration of FNRBCs with a low concentration and the accuracy of detetion for the diagnosis of fetal sex reached to 95%. Moreover, the obtained FNRBCs were applied to the non-invasive diagnosis of Down syndrome and chromosome 3p21 was de- tected. The above facts indicate that the novel multi-core magnetic composite particles-based method is simple, relia- ble and cost-effective and has opened up vast vistas for the potential application in clinic non-invasive prenatal diag- nosis.展开更多
Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to acc...Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to access the shared cache simultaneously.The main problem in improving memory performance is the shared cache architecture and cache replacement.This paper documents the implementation of a Dual-Port Content Addressable Memory(DPCAM)and a modified Near-Far Access Replacement Algorithm(NFRA),which was previously proposed as a shared L2 cache layer in a multi-core processor.Standard Performance Evaluation Corporation(SPEC)Central Processing Unit(CPU)2006 benchmark workloads are used to evaluate the benefit of the shared L2 cache layer.Results show improved performance of the multicore processor’s DPCAM and NFRA algorithms,corresponding to a higher number of concurrent accesses to shared memory.The new architecture significantly increases system throughput and records performance improvements of up to 8.7%on various types of SPEC 2006 benchmarks.The miss rate is also improved by about 13%,with some exceptions in the sphinx3 and bzip2 benchmarks.These results could open a new window for solving the long-standing problems with shared cache in multi-core processors.展开更多
A variation-aware task mapping approach is proposed for a multi-core network-on-chips with redundant cores, which includes both the design-time mapping and run-time scheduling algorithms. Firstly, a design-time geneti...A variation-aware task mapping approach is proposed for a multi-core network-on-chips with redundant cores, which includes both the design-time mapping and run-time scheduling algorithms. Firstly, a design-time genetic task mapping algorithm is proposed during the design stage to generate multiple task mapping solutions which cover a maximum range of chips. Then, during the run, one optimal task mapping solution is selected. Additionally, logical cores are mapped to physically available cores. Both core asymmetry and topological changes are considered in the proposed approach. Experimental results show that the performance yield of the proposed approach is 96% on average, and the communication cost, power consumption and peak temperature are all optimized without loss of performance yield.展开更多
Developing parallel applications on heterogeneous processors is facing the challenges of 'memory wall',due to limited capacity of local storage,limited bandwidth and long latency for memory access. Aiming at t...Developing parallel applications on heterogeneous processors is facing the challenges of 'memory wall',due to limited capacity of local storage,limited bandwidth and long latency for memory access. Aiming at this problem,a parallelization approach was proposed with six memory optimization schemes for CG,four schemes of them aiming at all kinds of sparse matrix-vector multiplication (SPMV) operation. Conducted on IBM QS20,the parallelization approach can reach up to 21 and 133 times speedups with size A and B,respectively,compared with single power processor element. Finally,the conclusion is drawn that the peak bandwidth of memory access on Cell BE can be obtained in SPMV,simple computation is more efficient on heterogeneous processors and loop-unrolling can hide local storage access latency while executing scalar operation on SIMD cores.展开更多
Decreasing mode coupling coefficient(κ) is an effective approach to suppress the inter-core crosstalk. Therefore, we deploy a low index rod and rectangle trench in the middle of two neighboring cores to reduce κ so ...Decreasing mode coupling coefficient(κ) is an effective approach to suppress the inter-core crosstalk. Therefore, we deploy a low index rod and rectangle trench in the middle of two neighboring cores to reduce κ so that the overlap of electric field distribution can be suppressed. We also propose approximate analytical solution(AAS) for κ of two crosstalk suppression models, which are two cores with one low index rod deployed in the middle and two cores with one low index rectangle trench deployed in the middle. We then do some modification for the results obtained by AAS and the modified results are proved to agree well with that obtained by finite element method(FEM). Therefore, we can use the modified AAS to get inter-core crosstalk for abovementioned two models quickly.展开更多
In this paper, the influencing factors that affect few-mode and multi core optical fiber channel are analyzed in a comprehensive way. The theoretical modeling and computer simulation of the information channel are car...In this paper, the influencing factors that affect few-mode and multi core optical fiber channel are analyzed in a comprehensive way. The theoretical modeling and computer simulation of the information channel are carried out and then the modeling scheme of few-mode multicore optical fiber channel based on non-uniform mode field distribution is put forward. The proposed modeling scheme can not only exponentially increases the system capacity through fewmode multi-core optical fiber channel, but has better transmission performance compared to the channel of the same type to the uniform channel revealing from the simulation results.展开更多
The developments of multi-core systems(MCS)have considerably improved the existing technologies in thefield of computer architecture.The MCS comprises several processors that are heterogeneous for resource capacities,...The developments of multi-core systems(MCS)have considerably improved the existing technologies in thefield of computer architecture.The MCS comprises several processors that are heterogeneous for resource capacities,working environments,topologies,and so on.The existing multi-core technology unlocks additional research opportunities for energy minimization by the use of effective task scheduling.At the same time,the task scheduling process is yet to be explored in the multi-core systems.This paper presents a new hybrid genetic algorithm(GA)with a krill herd(KH)based energy-efficient scheduling techni-que for multi-core systems(GAKH-SMCS).The goal of the GAKH-SMCS tech-nique is to derive scheduling tasks in such a way to achieve faster completion time and minimum energy dissipation.The GAKH-SMCS model involves a multi-objectivefitness function using four parameters such as makespan,processor utilization,speedup,and energy consumption to schedule tasks proficiently.The performance of the GAKH-SMCS model has been validated against two datasets namely random dataset and benchmark dataset.The experimental outcome ensured the effectiveness of the GAKH-SMCS model interms of makespan,pro-cessor utilization,speedup,and energy consumption.The overall simulation results depicted that the presented GAKH-SMCS model achieves energy effi-ciency by optimal task scheduling process in MCS.展开更多
This paper focuses on how to optimize the cache performance of sparse matrix-matrix multiplication(SpGEMM).It classifies the cache misses into two categories;one is caused by the irregular distribution pattern of the ...This paper focuses on how to optimize the cache performance of sparse matrix-matrix multiplication(SpGEMM).It classifies the cache misses into two categories;one is caused by the irregular distribution pattern of the multiplier-matrix,and the other is caused by the multiplicand.For each of them,the paper puts forward an optimization method respectively.The first hash based method removes cache misses of the 1 st category effectively,and improves the performance by a factor of 6 on an Intel 8-core CPU for the best cases.For cache misses of the 2nd category,it proposes a new cache replacement algorithm,which achieves a cache hit rate much higher than other historical knowledge based algorithms,and the algorithm is applicable on CELL and GPU.To further verify the effectiveness of our methods,we implement our algorithm on GPU,and the performance perfectly scales with the size of on-chip storage.展开更多
In this paper, a study related to the expected performance behaviour of present 3-level cache system for multi-core systems is presented. For this a queuing model for present 3-level cache system for multi-core proces...In this paper, a study related to the expected performance behaviour of present 3-level cache system for multi-core systems is presented. For this a queuing model for present 3-level cache system for multi-core processors is developed and its possible performance has been analyzed with the increase in number of cores. Various important performance parameters like access time and utilization of individual cache at different level and overall average access time of the cache system is determined. Results for up to 1024 cores have been reported in this paper.展开更多
In order to improve the concurrent access performance of the web-based spatial computing system in cluster,a parallel scheduling strategy based on the multi-core environment is proposed,which includes two levels of pa...In order to improve the concurrent access performance of the web-based spatial computing system in cluster,a parallel scheduling strategy based on the multi-core environment is proposed,which includes two levels of parallel processing mechanisms.One is that it can evenly allocate tasks to each server node in the cluster and the other is that it can implement the load balancing inside a server node.Based on the strategy,a new web-based spatial computing model is designed in this paper,in which,a task response ratio calculation method,a request queue buffer mechanism and a thread scheduling strategy are focused on.Experimental results show that the new model can fully use the multi-core computing advantage of each server node in the concurrent access environment and improve the average hits per second,average I/O Hits,CPU utilization and throughput.Using speed-up ratio to analyze the traditional model and the new one,the result shows that the new model has the best performance.The performance of the multi-core server nodes in the cluster is optimized;the resource utilization and the parallel processing capabilities are enhanced.The more CPU cores you have,the higher parallel processing capabilities will be obtained.展开更多
The first important problem in the star forming process is the formation of proto star core in star forming regions of molecular cloud. The multi core structure in star forming regions is related to the forming of pro...The first important problem in the star forming process is the formation of proto star core in star forming regions of molecular cloud. The multi core structure in star forming regions is related to the forming of proto star core. The molecular radiation of C 18 O( J = 1-0) in Cepheus C has been observed. The C 18 O( J = 1-0) observations form the basis for an interesting study on the cloud cores and star formation activity in the cores of the Cepheus C. In order to study the multi core structure of C 18 O( J = 1-0) in the Cepheus C the channel maps and the position velocity diagrams of C 18 O( J = 1-0) will be shown. From the maps it is found that the contour level and distribution size of the three cores in Cepheus C are related to the channel velocity very much. The channel velocity of C 18 O( J = 1-0) molecules in core b, which distributed in all the channels velocity, is different with one in core a and core c very much. The C 18 O( J = 1-0) molecules in core a and core c of the Cepheus C mostly distributed in the blue shifted channel velocity relating to peak velocity, and only in -10.0 ～ -9.5 km/s, which is the red shifted channel velocity relating to peak velocity. And the contour level of C 18 O( J = 1-0) in -10.0 ～ -9.5 km/s is small and the distrbution size in the channel map is small. According to the position velocity diagrams the asymmetry of the distribution both blue shifted and red shifted components should reflect the asymmetry of the profile. From the diagrams it also is found that the contour level and the distribution size of the three cores are different from each other. Both results from the maps and diagrams are coincident with each other.展开更多
Real-time system timing analysis is crucial for estimating the worst-case execution time(WCET)of a program.To achieve this,static or dynamic analysis methods are used,along with targeted modeling of the actual hardwar...Real-time system timing analysis is crucial for estimating the worst-case execution time(WCET)of a program.To achieve this,static or dynamic analysis methods are used,along with targeted modeling of the actual hardware system.This literature review focuses on calculating WCET for multi-core processors,providing a survey of traditional methods used for static and dynamic analysis and highlighting the major challenges that arise from different program execution scenarios on multi-core platforms.This paper outlines the strengths and weaknesses of current methodologies and offers insights into prospective areas of research on multi-core analysis.By presenting a comprehensive analysis of the current state of research on multi-core processor analysis for WCET estimation,this review aims to serve as a valuable resource for researchers and practitioners in the field.展开更多
文摘Naturally degradable capsule provides a platform for sustained fragrance release.However,practical challenges such as low encapsulation efficiency and difficulty in sustained release are still limited in using fragranceloaded capsules.In this work,the natural materials sodium alginate and gelatine are dissolved and act as the aqueous phase,lavender is dissolved in caprylic/capric triglyceride(GTCC)as the oil phase,and SiO_(2) nanoparticles with neutralwettability as a solid emulsifier to form O/W Pickering emulsions simultaneously.Finally,multi-core capsules are prepared using the drop injection method with emulsions as templates.The results show that the capsules have been successfully prepared with a spherical morphology and multi-core structure,and the encapsulation rate of multi-core capsules can reach up to 99.6%.In addition,the multi-core capsules possess desirable sustained release performance,the cumulative sustained release rate of fragrance at 25℃over 49 days is only 32.5%.It is attributed to the significant protection of multi-core structure,Pickering emulsion nanoparticle membranes,and hydrogel network shell for encapsulated fragrance.This study is designed to deliver a new strategy for using sustained-release technology with fragrance in food,cosmetics,textiles,and other fields.
基金supported by the National Natural Science Foundation of China under Grant No.92582204,No.62577007,and No.62177003the Fundamental Research Funds for the Central Universities under Grant No.JKF-2025011975129.
文摘Online programming platforms are popular in programming education.However,there has been no research investigating students’real opinions and expectations of the error feedback mechanisms,leaving educators without a solid data foundation when attempting to improve the error feedback mechanisms.This paper makes a survey of 834 students across various programming courses and investigates student perceptions of error feedback mechanisms on online programming platforms.It explores the effectiveness of existing feedback,student satisfaction,and preferences for potential improvements,focusing on automatic error localization and program repair mechanisms.Results reveal a significant portion of students are dissatisfied with current feedback due to its limited informativeness.Students also express a clear demand for stronger feedback mechanisms,such as error localization and repair hints.Nevertheless,they prefer feedback that subtly guides them toward solutions,rather than providing direct and explicit answers,valuing the opportunity to enhance their debugging skills.The findings suggest a need for balanced,educational-focused feedback mechanisms that aid learning while promoting independent problem-solving.
基金financially supported by Ministerio de Ciencia e Innovación projects SAF2017-82736-C2-1-R to MTMFin Universidad Autónoma de Madrid and by Fundación Universidad Francisco de Vitoria to JS+2 种基金a predoctoral scholarship from Fundación Universidad Francisco de Vitoriafinancial support from a 6-month contract from Universidad Autónoma de Madrida 3-month contract from the School of Medicine of Universidad Francisco de Vitoria。
文摘Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons.
基金Supported by the National Natural Science Foundation of China(Grant Nos.12571317 and 12071133).
文摘In this paper,we study a class of Linear Fractional Programming on a nonempty bounded set,called the Problem(LFP),and design a branch and bound algorithm to find the global optimal solution of the problem(LFP).First,we convert the problem(LFP)to the equivalent problem(EP2).Secondly,by applying the linear relaxation technique to the problem(EP2),the linear relaxation programming problem(LRP2Y)was obtained.Then,the overall framework of the algorithm is given,and the convergence and complexity of the algorithm are analyzed.Finally,experimental results are listed to illustrate the effectiveness of the algorithm.
文摘Aiming at the problem of innovative talent training in the industry field in characteristic software colleges,combined with the actual situation of Software College of Northeastern University,this paper analyzes the construction requirements of characteristic talent training mode and training scheme,puts forward the reform of characteristic software innovative talent training scheme integrating production and education,and takes the characteristic direction of financial technology as an example to introduce the curriculum construction based on industry-education integration and school-enterprise cooperation.
基金financially supported by the Natural Science Foundation of Jiangsu Province (No.BK20200709)the Natural Science Foundation of China (Nos.62288102,32201127 and 82270113)+2 种基金the Natural Science Foundation of Guangdong Province (No.2023A1515011386)the Natural Science Foundation of the Jiangsu Higher Education Institutes (No.20KJB430031)the startup fund from Nanjing Tech University,and Disciplinary Fund of School of Pharmaceutical Sciences (2024)。
文摘The field of nanomedicine has been revolutionized by the concept of immunogenic cell death(ICD)-enhanced cancer therapy,which holds immense promise for the efficient treatment of cancer.However,precise delivery of ICD inducer is severely hindered by complex biological barriers.How to design and build intelligent nanoplatform for adaptive and dynamic cancer therapy remains a big challenge.Herein,this article presents the design and preparation of CD44-targeting and ZIF-8 gated gold nanocage(Au@ZH) for programmed delivery of the 1,2-diaminocyclohexane-Pt(Ⅱ)(DACHPt) as ICD inducer.After actively targeting the CD44 on the surface of 4T1 tumor cell,this Pt-Au@ZH can be effectively endocytosed by the 4T1 cell and release the DACHPt in tumor acidic environment,resulting in ICD effect and superior antitumor efficacy both in vitro and in vivo in the presence of mild 808 nm laser irradiation.By integration of internal and external stimuli intelligently,this programmed nanoplatform is poised to become a cornerstone in the pursuit of effective and targeted cancer therapy in the foreseeable future.
基金supported by the National Natural Sci‐ence Foundation of China(Grant No.62306325)。
文摘During the use of robotics in applications such as antiterrorism or combat,a motion-constrained pursuer vehicle,such as a Dubins unmanned surface vehicle(USV),must get close enough(within a prescribed zero or positive distance)to a moving target as quickly as possible,resulting in the extended minimum-time intercept problem(EMTIP).Existing research has primarily focused on the zero-distance intercept problem,MTIP,establishing the necessary or sufficient conditions for MTIP optimality,and utilizing analytic algorithms,such as root-finding algorithms,to calculate the optimal solutions.However,these approaches depend heavily on the properties of the analytic algorithm,making them inapplicable when problem settings change,such as in the case of a positive effective range or complicated target motions outside uniform rectilinear motion.In this study,an approach employing a high-accuracy and quality-guaranteed mixed-integer piecewise-linear program(QG-PWL)is proposed for the EMTIP.This program can accommodate different effective interception ranges and complicated target motions(variable velocity or complicated trajectories).The high accuracy and quality guarantees of QG-PWL originate from elegant strategies such as piecewise linearization and other developed operation strategies.The approximate error in the intercept path length is proved to be bounded to h^(2)/(4√2),where h is the piecewise length.
文摘A novel kind of multi-core magnetic composite particles, the surfaces of which were respectively mo- dified with goat-anti-mouse IgG and antitransferrin receptor（anti-CD71）, was prepared. The fetal nucleated red blood cells（FNRBCs） in the peripheral blood of a gravida were rapidly and effectively enriched and separated by the mo- dified multi-core magnetic composite particles in an external magnetic field. The obtained FNRBCs were used for the identification of the fetal sex by means of fluorescence in situ hybridization（FISH） technique. The results demonstrate that the multi-core magnetic composite particles meet the requirements for the enrichment and speration of FNRBCs with a low concentration and the accuracy of detetion for the diagnosis of fetal sex reached to 95%. Moreover, the obtained FNRBCs were applied to the non-invasive diagnosis of Down syndrome and chromosome 3p21 was de- tected. The above facts indicate that the novel multi-core magnetic composite particles-based method is simple, relia- ble and cost-effective and has opened up vast vistas for the potential application in clinic non-invasive prenatal diag- nosis.
文摘Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to access the shared cache simultaneously.The main problem in improving memory performance is the shared cache architecture and cache replacement.This paper documents the implementation of a Dual-Port Content Addressable Memory(DPCAM)and a modified Near-Far Access Replacement Algorithm(NFRA),which was previously proposed as a shared L2 cache layer in a multi-core processor.Standard Performance Evaluation Corporation(SPEC)Central Processing Unit(CPU)2006 benchmark workloads are used to evaluate the benefit of the shared L2 cache layer.Results show improved performance of the multicore processor’s DPCAM and NFRA algorithms,corresponding to a higher number of concurrent accesses to shared memory.The new architecture significantly increases system throughput and records performance improvements of up to 8.7%on various types of SPEC 2006 benchmarks.The miss rate is also improved by about 13%,with some exceptions in the sphinx3 and bzip2 benchmarks.These results could open a new window for solving the long-standing problems with shared cache in multi-core processors.
文摘A variation-aware task mapping approach is proposed for a multi-core network-on-chips with redundant cores, which includes both the design-time mapping and run-time scheduling algorithms. Firstly, a design-time genetic task mapping algorithm is proposed during the design stage to generate multiple task mapping solutions which cover a maximum range of chips. Then, during the run, one optimal task mapping solution is selected. Additionally, logical cores are mapped to physically available cores. Both core asymmetry and topological changes are considered in the proposed approach. Experimental results show that the performance yield of the proposed approach is 96% on average, and the communication cost, power consumption and peak temperature are all optimized without loss of performance yield.
基金Project(2008AA01A201) supported the National High-tech Research and Development Program of ChinaProjects(60833004, 60633050) supported by the National Natural Science Foundation of China
文摘Developing parallel applications on heterogeneous processors is facing the challenges of 'memory wall',due to limited capacity of local storage,limited bandwidth and long latency for memory access. Aiming at this problem,a parallelization approach was proposed with six memory optimization schemes for CG,four schemes of them aiming at all kinds of sparse matrix-vector multiplication (SPMV) operation. Conducted on IBM QS20,the parallelization approach can reach up to 21 and 133 times speedups with size A and B,respectively,compared with single power processor element. Finally,the conclusion is drawn that the peak bandwidth of memory access on Cell BE can be obtained in SPMV,simple computation is more efficient on heterogeneous processors and loop-unrolling can hide local storage access latency while executing scalar operation on SIMD cores.
基金supported by National B a-sic Research Program of China(Grant No.2012CB315905)National Natural Science Foundation of China(Grant No.61501027)+1 种基金China Postdoctoral Science Foundation(Grant No.2015M570934)Fundamental Research Funds for the Central Universities(Grant No.FRF-TP-15-031A1)
文摘Decreasing mode coupling coefficient(κ) is an effective approach to suppress the inter-core crosstalk. Therefore, we deploy a low index rod and rectangle trench in the middle of two neighboring cores to reduce κ so that the overlap of electric field distribution can be suppressed. We also propose approximate analytical solution(AAS) for κ of two crosstalk suppression models, which are two cores with one low index rod deployed in the middle and two cores with one low index rectangle trench deployed in the middle. We then do some modification for the results obtained by AAS and the modified results are proved to agree well with that obtained by finite element method(FEM). Therefore, we can use the modified AAS to get inter-core crosstalk for abovementioned two models quickly.
基金supports from National High Technology 863 Program of China(No.2013AA013403,2015AA015501,2015AA015502,2015AA015504)National NSFC(No.61425022/61522501/61307086/61475024/61275158/61201151/61275074/61372109)+4 种基金Beijing Nova Program(No.Z141101001814048)Beijing Excellent Ph.D.Thesis Guidance Foundation(No.20121001302)the Universities Ph.D.Special Research Funds(No.20120005110003/20120005120007)Fund of State Key Laboratory of IPOC(BUPT)P.R.China
文摘In this paper, the influencing factors that affect few-mode and multi core optical fiber channel are analyzed in a comprehensive way. The theoretical modeling and computer simulation of the information channel are carried out and then the modeling scheme of few-mode multicore optical fiber channel based on non-uniform mode field distribution is put forward. The proposed modeling scheme can not only exponentially increases the system capacity through fewmode multi-core optical fiber channel, but has better transmission performance compared to the channel of the same type to the uniform channel revealing from the simulation results.
基金supported by Taif University Researchers Supporting Program(Project Number:TURSP-2020/195)Taif University,Saudi Arabia.Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2022R203)Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘The developments of multi-core systems(MCS)have considerably improved the existing technologies in thefield of computer architecture.The MCS comprises several processors that are heterogeneous for resource capacities,working environments,topologies,and so on.The existing multi-core technology unlocks additional research opportunities for energy minimization by the use of effective task scheduling.At the same time,the task scheduling process is yet to be explored in the multi-core systems.This paper presents a new hybrid genetic algorithm(GA)with a krill herd(KH)based energy-efficient scheduling techni-que for multi-core systems(GAKH-SMCS).The goal of the GAKH-SMCS tech-nique is to derive scheduling tasks in such a way to achieve faster completion time and minimum energy dissipation.The GAKH-SMCS model involves a multi-objectivefitness function using four parameters such as makespan,processor utilization,speedup,and energy consumption to schedule tasks proficiently.The performance of the GAKH-SMCS model has been validated against two datasets namely random dataset and benchmark dataset.The experimental outcome ensured the effectiveness of the GAKH-SMCS model interms of makespan,pro-cessor utilization,speedup,and energy consumption.The overall simulation results depicted that the presented GAKH-SMCS model achieves energy effi-ciency by optimal task scheduling process in MCS.
基金Supported by the National High Technology Research and Development Programme of China(No.2010AA012302,2009AA01 A134)Tsinghua National Laboratory for Information Science and Technology(TNList)Cross-discipline Foundation
文摘This paper focuses on how to optimize the cache performance of sparse matrix-matrix multiplication(SpGEMM).It classifies the cache misses into two categories;one is caused by the irregular distribution pattern of the multiplier-matrix,and the other is caused by the multiplicand.For each of them,the paper puts forward an optimization method respectively.The first hash based method removes cache misses of the 1 st category effectively,and improves the performance by a factor of 6 on an Intel 8-core CPU for the best cases.For cache misses of the 2nd category,it proposes a new cache replacement algorithm,which achieves a cache hit rate much higher than other historical knowledge based algorithms,and the algorithm is applicable on CELL and GPU.To further verify the effectiveness of our methods,we implement our algorithm on GPU,and the performance perfectly scales with the size of on-chip storage.
文摘In this paper, a study related to the expected performance behaviour of present 3-level cache system for multi-core systems is presented. For this a queuing model for present 3-level cache system for multi-core processors is developed and its possible performance has been analyzed with the increase in number of cores. Various important performance parameters like access time and utilization of individual cache at different level and overall average access time of the cache system is determined. Results for up to 1024 cores have been reported in this paper.
基金Supported by the China Postdoctoral Science Foundation(No.2014M552115)the Fundamental Research Funds for the Central Universities,ChinaUniversity of Geosciences(Wuhan)(No.CUGL140833)the National Key Technology Support Program of China(No.2011BAH06B04)
文摘In order to improve the concurrent access performance of the web-based spatial computing system in cluster,a parallel scheduling strategy based on the multi-core environment is proposed,which includes two levels of parallel processing mechanisms.One is that it can evenly allocate tasks to each server node in the cluster and the other is that it can implement the load balancing inside a server node.Based on the strategy,a new web-based spatial computing model is designed in this paper,in which,a task response ratio calculation method,a request queue buffer mechanism and a thread scheduling strategy are focused on.Experimental results show that the new model can fully use the multi-core computing advantage of each server node in the concurrent access environment and improve the average hits per second,average I/O Hits,CPU utilization and throughput.Using speed-up ratio to analyze the traditional model and the new one,the result shows that the new model has the best performance.The performance of the multi-core server nodes in the cluster is optimized;the resource utilization and the parallel processing capabilities are enhanced.The more CPU cores you have,the higher parallel processing capabilities will be obtained.
文摘The first important problem in the star forming process is the formation of proto star core in star forming regions of molecular cloud. The multi core structure in star forming regions is related to the forming of proto star core. The molecular radiation of C 18 O( J = 1-0) in Cepheus C has been observed. The C 18 O( J = 1-0) observations form the basis for an interesting study on the cloud cores and star formation activity in the cores of the Cepheus C. In order to study the multi core structure of C 18 O( J = 1-0) in the Cepheus C the channel maps and the position velocity diagrams of C 18 O( J = 1-0) will be shown. From the maps it is found that the contour level and distribution size of the three cores in Cepheus C are related to the channel velocity very much. The channel velocity of C 18 O( J = 1-0) molecules in core b, which distributed in all the channels velocity, is different with one in core a and core c very much. The C 18 O( J = 1-0) molecules in core a and core c of the Cepheus C mostly distributed in the blue shifted channel velocity relating to peak velocity, and only in -10.0 ～ -9.5 km/s, which is the red shifted channel velocity relating to peak velocity. And the contour level of C 18 O( J = 1-0) in -10.0 ～ -9.5 km/s is small and the distrbution size in the channel map is small. According to the position velocity diagrams the asymmetry of the distribution both blue shifted and red shifted components should reflect the asymmetry of the profile. From the diagrams it also is found that the contour level and the distribution size of the three cores are different from each other. Both results from the maps and diagrams are coincident with each other.
基金supported by ZTE Industry-University-Institute Cooperation Funds under Grant No.2022ZTE09.
文摘Real-time system timing analysis is crucial for estimating the worst-case execution time(WCET)of a program.To achieve this,static or dynamic analysis methods are used,along with targeted modeling of the actual hardware system.This literature review focuses on calculating WCET for multi-core processors,providing a survey of traditional methods used for static and dynamic analysis and highlighting the major challenges that arise from different program execution scenarios on multi-core platforms.This paper outlines the strengths and weaknesses of current methodologies and offers insights into prospective areas of research on multi-core analysis.By presenting a comprehensive analysis of the current state of research on multi-core processor analysis for WCET estimation,this review aims to serve as a valuable resource for researchers and practitioners in the field.
