Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’...Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.展开更多
Tellurene,a chiral chain semiconductor with a narrow bandgap and exceptional strain sensitivity,emerges as a pivotal material for tailoring electronic and optoelectronic properties via strain engineering.This study el...Tellurene,a chiral chain semiconductor with a narrow bandgap and exceptional strain sensitivity,emerges as a pivotal material for tailoring electronic and optoelectronic properties via strain engineering.This study elucidates the fundamental mechanisms of ultrafast laser shock imprinting(LSI)in two-dimensional tellurium(Te),establishing a direct relationship between strain field orientation,mold topology,and anisotropic structural evolution.This is the first demonstration of ultrafast LSI on chiral chain Te unveiling orientation-sensitive dislocation networks.By applying controlled strain fields parallel or transverse to Te’s helical chains,we uncover two distinct deformation regimes.Strain aligned parallel to the chain’s direction induces gliding and rotation governed by weak interchain interactions,preserving covalent intrachain bonds and vibrational modes.In contrast,transverse strain drives shear-mediated multimodal deformations—tensile stretching,compression,and bending—resulting in significant lattice distortions and electronic property modulation.We discovered the critical role of mold topology on deformation:sharp-edged gratings generate localized shear forces surpassing those from homogeneous strain fields via smooth CD molds,triggering dislocation tangle formation,lattice reorientation,and inhomogeneous plastic deformation.Asymmetrical strain configurations enable localized structural transformations while retaining single-crystal integrity in adjacent regions—a balance essential for functional device integration.These insights position LSI as a precision tool for nanoscale strain engineering,capable of sculpting 2D material morphologies without compromising crystallinity.By bridging ultrafast mechanics with chiral chain material science,this work advances the design of strain-tunable devices for next-generation electronics and optoelectronics,while establishing a universal framework for manipulating anisotropic 2D systems under extreme strain rates.This work discovered crystallographic orientation-dependent deformation mechanisms in 2D Te,linking parallel strain to chain gliding and transverse strain to shear-driven multimodal distortion.It demonstrates mold geometry as a critical lever for strain localization and dislocation dynamics,with sharp-edged gratings enabling unprecedented control over lattice reorientation.Crucially,the identification of strain field conditions that reconcile severe plastic deformation with single-crystal retention offers a pathway to functional nanostructure fabrication,redefining LSI’s potential in ultrafast strain engineering of chiral chain materials.展开更多
The concept of Supply Chain 4.0 represents a transformative phase in supply chain management through advanced digital technologies like IoT, AI, blockchain, and cyber-physical systems. While these innovations deliver ...The concept of Supply Chain 4.0 represents a transformative phase in supply chain management through advanced digital technologies like IoT, AI, blockchain, and cyber-physical systems. While these innovations deliver operational improvements, the heightened interconnectivity introduces significant cybersecurity challenges, particularly within military logistics, where mission-critical operations and life-safety concerns are paramount. This paper examines these unique cybersecurity requirements, focusing on advanced persistent threats, supply chain poisoning, and data breaches that could compromise sensitive operations. The study proposes a hybrid cybersecurity framework tailored to military logistics, integrating resilience, redundancy, and cross-jurisdictional security measures. Real-world applicability is validated through simulations, offering strategies for securing supply chains while balancing security, efficiency, and flexibility.展开更多
Amid the escalating plastic pollution issue, the development of biodegradable and recyclable polymeric materials has become a focus within the scientific community. Chain extenders, which are an important class of com...Amid the escalating plastic pollution issue, the development of biodegradable and recyclable polymeric materials has become a focus within the scientific community. Chain extenders, which are an important class of compounds, facilitate the elongation of polymer chains through reactive functional groups, thereby enhancing the performance of the materials. Epoxy-based chain extenders, due to their cost-effectiveness, low toxicity, high reaction efficiency, and effective reactivity with hydroxyl and carboxyl groups, have emerged as a promising class of chain extenders. This manuscript comprehensively elaborates on the varieties, structural characteristics, and performance of chain extenders, the challenges they face, and the methods for their modification. Special emphasis is placed on the application of epoxy-based chain extenders in biodegradable polymers, such as polylactic acid (PLA), and their subsequent influence on the structural and performance properties of these materials.展开更多
Control Flow Graphs(CFGs)are essential for understanding the execution and data flow within software,serving as foundational structures in program analysis.Traditional CFG construction methods,such as bytecode analysi...Control Flow Graphs(CFGs)are essential for understanding the execution and data flow within software,serving as foundational structures in program analysis.Traditional CFG construction methods,such as bytecode analysis and Abstract Syntax Trees(ASTs),often face challenges due to the complex syntax of programming languages like Java and Python.This paper introduces a novel approach that leverages Large Language Models(LLMs)to generate CFGs through a methodical Chain of Thought(CoT)process.By employing CoT,the proposed approach systematically interprets code semantics directly from natural language,enhancing the adaptability across various programming languages and simplifying the CFG construction process.By implementing a modular AI chain strategy that adheres to the single responsibility principle,our approach breaks down CFG generation into distinct,manageable steps handled by separate AI and non-AI units,which can significantly improve the precision and coverage of CFG nodes and edges.The experiments with 245 Java and 281 Python code snippets from Stack Overflow demonstrate that our method achieves efficient performance on different programming languages and exhibits strong robustness.展开更多
Frequent glacier-related watershed geohazard chains are causing severe damage to life and infrastructure,reported consistently from the Eastern Himalayan Syntaxis.This paper presents a systematic method for researchin...Frequent glacier-related watershed geohazard chains are causing severe damage to life and infrastructure,reported consistently from the Eastern Himalayan Syntaxis.This paper presents a systematic method for researching geohazard,from regional to individual scale.The methodology includes the establishment of geological chain inventories,discrimination of geohazard chain modes,analyses of dynamics and dam breaches,and risk assessments.The following results were obtained:(1)In the downstream of Yarlung Zangbo River,175 sites were identified as high-risk for river blockage disasters,indicating the development of watershed geohazards.Five geohazard chain modes were summarized by incorporating geomorphological characteristics,historical events,landslide zoning,and materials.The risk areas of typical hazard were identified and assessed using InSAR data.(2)Glacier-related watershed geohazard chains are significantly different from traditional landslides.A detailed inversion analysis was conducted on the massive rock-ice avalanche in the Sedongpu gully in 2021.This particular event lasted roughly 300 seconds,with a maximum flow velocity of 77.2 m/s and a maximum flow height of 93 meters.By scrutinizing the dynamic processes and mechanical characteristics,mobility stages and phase transitions can be divided into four stages.(3)Watershed geohazard chains tend to block rivers.The peak breach discharge of the Yigong Landslide reached 12.4×10^(4) m^(3)/s,which is 36 times the volume of the seasonal flood discharge in the Yigong River.Megafloods caused by landslide dam breaches have significantly shaped the geomorphology.This study offers insights into disaster patterns and the multistaged movement characteristics of glacier-related watershed geohazard chains,providing a comprehensive method for investigations and assessments in glacial regions.展开更多
To solve the challenges of connecting and coordinating multiple platforms in the automotive industry and to enhance collaboration among different participants,this research focuses on addressing the complex supply rel...To solve the challenges of connecting and coordinating multiple platforms in the automotive industry and to enhance collaboration among different participants,this research focuses on addressing the complex supply relationships in the automotive market,improving data sharing and interactions across various platforms,and achieving more detailed integration of data and operations.We propose a trust evaluation permission delegation method based on the automotive industry chain.The proposed method combines smart contracts with trust evaluation mechanisms,dynamically calculating the trust value of users based on the historical behavior of the delegated entity,network environment,and other factors to avoid malicious node attacks during the permission delegation process.We also introduce strict control over the cross-domain permission granting and revocation mechanisms to manage the delegation path,prevent information leakage caused by malicious node interception,and effectively protect data integrity and privacy.Experimental analysis shows that this method meets the realtime requirements of collaborative interaction in the automotive industry chain and provides a feasible solution to permission delegation issues in the automotive industry chain,offering dynamic flexibility in authorization and scalability compared to most existing solutions.展开更多
In response to the challenges presented by the unreliable identity of the master node,high communication overhead,and limited network support size within the Practical Byzantine Fault-Tolerant(PBFT)algorithm for conso...In response to the challenges presented by the unreliable identity of the master node,high communication overhead,and limited network support size within the Practical Byzantine Fault-Tolerant(PBFT)algorithm for consortium chains,we propose an improved PBFT algorithm based on XGBoost grouping called XG-PBFT in this paper.XG-PBFT constructs a dataset by training important parameters that affect node performance,which are used as classification indexes for nodes.The XGBoost algorithm then is employed to train the dataset,and nodes joining the system will be grouped according to the trained grouping model.Among them,the nodes with higher parameter indexes will be assigned to the consensus group to participate in the consensus,and the rest of the nodes will be assigned to the general group to receive the consensus results.In order to reduce the resource waste of the system,XG-PBFT optimizes the consensus protocol for the problem of high complexity of PBFT communication.Finally,we evaluate the performance of XG-PBFT.The experimental results show that XG-PBFT can significantly improve the performance of throughput,consensus delay and communication complexity compared to the original PBFT algorithm,and the performance enhancement is significant compared to other algorithms in the case of a larger number of nodes.The results demonstrate that the XG-PBFT algorithm is more suitable for large-scale consortium chains.展开更多
The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the gl...The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the global trade analysis project(GTAP)model to evaluate the impact of RCEP on AVC of member countries in terms of time,tariff reduction,and reduction of non-tariff barriers(NTB).The results indicate that(1)the implementation of RCEP boosts the value-added to agricultural exports for most member countries,particularly in competitive industries;(2)the increase in domestic production and processing capacity,reflected in domestic value-added(DVA),is the primary factor driving the rise in the value-added of agricultural exports across various industries of member countries;(3)RCEP enhances the participation of most regional countries in AVC,with varying impacts on AVC positioning,thereby fostering regional AvC development;and(4)RCEP has a positive effect on AVC indicators both in the short and long term,with the effect becoming more pronounced over time.Additionally,reducing NTB enhances the positive effects of tariff reductions on AVC indicators.Based on the analyses,the following recommendations are proposed:(1)Leverage the development opportunities arising from RCEP implementation to enhance the agricultural DVA;(2)capitalize on cooperative opportunities created by RCEP to build cohesive regional AVC;and(3)prioritize the effective implementation of RCEP'shigh-qualityrules.展开更多
The rapid advancement of radar and 5 G communication technologies has created an urgent need for materials that possess both low dielectric constants and superior mechanical strength to ensure efficient signal transmi...The rapid advancement of radar and 5 G communication technologies has created an urgent need for materials that possess both low dielectric constants and superior mechanical strength to ensure efficient signal transmission and minimal loss.Herein,a synergistic effect of multiple regulation strategies from the atomic scales to the molecular scales was proposed to develop Covalent Organic Frameworks(COFs)modified cyanate ester resins(COF-mCE).The strategy has proven highly effective in enhancing both dielectric and mechanical properties.With only 3 wt%COFs,the dielectric constant of COF-mCE is reduced from 3.32 to 2.84 at 1 MHz.Meanwhile,the mechanical performance of COF-mCE composites exhibits substantial improvements,with flexural strength increasing by 42.6% and tensile strength by 52.1% compared to pure mCE.The investigation explores that hydrogen bonding and π-π stacking interactions restrain the polarization feature and the mechanical property improvements of the COF-mCE derived from the entanglement effect of COF-polymer chains.Furthermore,the 3D-printed COF-mCE honeycomb structure demonstrates excellent electromagnetic wave transmittance and low reflectance,achieving a transmittance of 94.1% at 10 GHz with a 60°incidence angle.This multi-scale design strategy offers new insights into the development of low-k dielectric material for next-generation electronic science applications.展开更多
A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety problems.Our study addresses the...A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety problems.Our study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves conductivity.mPR-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain dispersion.Integrating this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 cycles.In situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen reactions.Ex situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability tests.The present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.展开更多
A glacier hazard chain can form a long-runout mass flow and generate a large flood,affecting downstream areas hundreds of kilometers away from the initiating hazard site.This study focuses on the Yarlung Zangbo Daxiag...A glacier hazard chain can form a long-runout mass flow and generate a large flood,affecting downstream areas hundreds of kilometers away from the initiating hazard site.This study focuses on the Yarlung Zangbo Daxiagu.The objective is to address two key unresolved issues:the evolution of detached glacier materials into debris flows or debris floods and the amplification of the impact range and threats.A comprehensive framework is developed that considers the impacts of near-field and far-field hazards.Numerical modeling,remote sensing,and field investigations were integrated to understand the interactions,transformations,and amplifications of hazards in the glacier hazard chain.The results indicate that extensive,nearly saturated sediments on the glacier valley floor,when entrained,amplify the magnitude of the mass flow.The topography plays a crucial role.When the valley outlet is perpendicular to the river course,topographic obstacles cause immediate halting,resulting in the formation of high barrier dams.Conversely,when the glacier valley aligns nearly parallel to the river course,the mass flow can travel a much longer distance upon entering the river,causing an enlarged affected area.The barrier dams can breach rapidly,causing breaching floods that amplify the downstream impact from several kilometers to hundreds of kilometers.Our analysis reveals that the overall impacts remain spatially limited.Specifically,downstream areas along the Yarlung Zangbo-Brahmaputra River are unlikely to face greater threats from the upstream floods than local monsoon floods.Our findings provide the foundation for the management of glacier hazard chains.展开更多
The philosophical concept of one bond connecting the world is an established scientific and economic phenomenon today.The global industrial and supply chains are symbols of that universal link of fraternity,cooperatio...The philosophical concept of one bond connecting the world is an established scientific and economic phenomenon today.The global industrial and supply chains are symbols of that universal link of fraternity,cooperation and globalization.Despite a few major economies still trying to push forward a decoupling agenda and favoring a“small yard,high fence”strategy,globalization and cooperation remain a global trend.展开更多
Global coffee giant Starbucks has been rooted in the Chinese market for 26 years,committed to bringing high-quality products and excellent experiences to consumers.As an“old friend”of the China International Supply ...Global coffee giant Starbucks has been rooted in the Chinese market for 26 years,committed to bringing high-quality products and excellent experiences to consumers.As an“old friend”of the China International Supply Chain Expo(herei naf ter refer red to as the“CISCE”),Starbucks has participated in this event for two consecutive years and will draw a blueprint for the sustainable development of the coffee industry from the perspective of building a green industrial and supply chain at the 3rd CISCE.展开更多
As there are numerous challenges to the global industrial and supply chains,the China International Supply Chain Expo(hereinafter referred to as the“CISCE”)hosted by the China Council for the Promotion of Internatio...As there are numerous challenges to the global industrial and supply chains,the China International Supply Chain Expo(hereinafter referred to as the“CISCE”)hosted by the China Council for the Promotion of International Trade(CCPIT),has been playing a unique role as a“stabilizer”for international cooperation,an“accelerator”for economic development,and a“booster”for future transformation.展开更多
An efficient strategy has been developed to reconstruct chain folding and traversing of poly(L-lactide)(PLLA)during melt crystallization based on the selective hydrolysis of its amorphous regions.The molecular weights...An efficient strategy has been developed to reconstruct chain folding and traversing of poly(L-lactide)(PLLA)during melt crystallization based on the selective hydrolysis of its amorphous regions.The molecular weights of the pristine PLLA(crystalline part),single stem,and single cluster were determined by gel permeation chromatography(GPC)according to their evolution during alkali hydrolysis.The maximum-folding-number(in a single cluster)and minimum-cluster-number(in one polymer chain)were obtained using these molecular weights.With the help of two numbers,the chain folding and traversing during the melt crystallization process(at 120℃)of PLLA can be described as follows.Statistically,in a single polymer chain,there are at least 2 clusters consisting of up to 6.5 stems in each of them,while the rest of the polymer chain contributes to amorphous regions.Our results provide a new strategy for the investigation and fundamental understanding of the melt crystallization of PLLA.展开更多
The China International Supply Chain Expo is an important window through which to observe the trends of China's supply chain transformation.GEOPOLITICAL unrest,climate change challenges,and advances in digital tec...The China International Supply Chain Expo is an important window through which to observe the trends of China's supply chain transformation.GEOPOLITICAL unrest,climate change challenges,and advances in digital technology have reshaped the global supply chain in recent years.展开更多
A substantial body of research has been conducted with the objective of enhancing the understanding of Non-Timber Forest Products (NTFP) in Central Africa. A significant proportion of the studies focus on medicinal pl...A substantial body of research has been conducted with the objective of enhancing the understanding of Non-Timber Forest Products (NTFP) in Central Africa. A significant proportion of the studies focus on medicinal plants, in contrast to those that examine food products. Nevertheless, studies on edible wild mushrooms as NTFPs and cultivated mushrooms, on their economic potential and value chains in the Great Lakes Region, remain scarce and largely absent for some NTFPs. In light of the aforementioned considerations, the present study aims to examine the economic potential and value chain of the production sector of wild edible mushrooms (WEM) and cultivated mushrooms (CM) within the Virunga National Park (PNVi) and its surrounding areas in North Kivu, Democratic Republic of the Congo (DRC). To this end, a sample of 432 respondents was selected, distributed equitably among the actors of the Goma-Kitshanga-Mweso value chain, the Goma-Rutshuru chain, the Beni-Mutwanga chain, and the Beni-Mangina chain. A digital questionnaire consisting of open and closed questions was administered, and observations were carried out concurrently. The quantities of mushrooms sold were weighed and photographed. The results demonstrated that, when the eight-month fruiting period of wild and cultivated mushrooms was considered as a single year for all actors within the value chain, a picker could sell 6.1 kg at $2 and earn $12. A seller could sell 16 kg at $4 and earn $64, while a grower could sell 502 kg at $3 and earn $1506. Consequently, the CM grower generates a significantly higher profit than other participants in the value chain, despite the expenses he incurs. Ultimately, the domestication of WEM, highly prized by the local population of the Virunga National Park, has the potential to enhance their household incomes, as evidenced by the findings of this study.展开更多
We investigate the mixed-state entanglement between two spins embedded in the XXZ Heisenberg chain under thermal equilibrium.By deriving an analytical expression for the entanglement of two-spin thermal states and ext...We investigate the mixed-state entanglement between two spins embedded in the XXZ Heisenberg chain under thermal equilibrium.By deriving an analytical expression for the entanglement of two-spin thermal states and extending this analysis to larger spin chains,we demonstrate that mixed-state entanglement is profoundly shaped by both disorder and temperature.Our results reveal a sharp distinction between many-body localized and ergodic phases,with entanglement vanishing above diferent fnite temperature thresholds.Furthermore,by analyzing non-adjacent spins,we uncover an approximate exponential decay of entanglement with separation.This work advances the understanding of the quantum-to-classical transition by linking the entanglement properties of small subsystems to the broader thermal environment,ofering an explanation for the absence of entanglement in macroscopic systems.These fndings provide critical insights into quantum many-body physics,bridging concepts from thermalization,localization,and quantum information theory.展开更多
Microbial chain elongation(CE),utilizing anaerobic fermentation for the synthesis of high-value medium chain fatty acids(MCFAs),merges as a promising strategy in resource sustainability.Recently,it has pivoted that th...Microbial chain elongation(CE),utilizing anaerobic fermentation for the synthesis of high-value medium chain fatty acids(MCFAs),merges as a promising strategy in resource sustainability.Recently,it has pivoted that the use of different types of additives or accelerantstowards enhancing the products yield and fermentation quality has got much attention,with carbon-based materials emerging as vital facilitators.Based on bibliometrics insights,this paper firstly commences with a comprehensive review of the past two decades’progress in applying carbon-based materials within anaerobic fermentation contexts.Subsequently,the recent advancements made by different research groups in order to enhance the performance of CE systemperformance are reviewed,with particular focus on the application,impact,and underlying mechanisms of carbon-based materials in expediting MCFAs biosynthesis via CE.Finally,the future research direction is prospected,aiming to inform innovative material design and sophisticated technological applications,as well as provide a reference for improving the efficiency of anaerobic fermentation of MCFAs using carbon-based material,thereby contributing to the broader discourse on enhancing sustainability and efficiency in bio-based processes.展开更多
基金supported by the National Key R&D Program of China,No.2021YFC2501200(to PC).
文摘Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.
基金financial support from NSF ExpandQISE program.The synthesis of tellurene was supported by NSF under grant no.CMMI-2046936supports from Purdue Research Foundation.
文摘Tellurene,a chiral chain semiconductor with a narrow bandgap and exceptional strain sensitivity,emerges as a pivotal material for tailoring electronic and optoelectronic properties via strain engineering.This study elucidates the fundamental mechanisms of ultrafast laser shock imprinting(LSI)in two-dimensional tellurium(Te),establishing a direct relationship between strain field orientation,mold topology,and anisotropic structural evolution.This is the first demonstration of ultrafast LSI on chiral chain Te unveiling orientation-sensitive dislocation networks.By applying controlled strain fields parallel or transverse to Te’s helical chains,we uncover two distinct deformation regimes.Strain aligned parallel to the chain’s direction induces gliding and rotation governed by weak interchain interactions,preserving covalent intrachain bonds and vibrational modes.In contrast,transverse strain drives shear-mediated multimodal deformations—tensile stretching,compression,and bending—resulting in significant lattice distortions and electronic property modulation.We discovered the critical role of mold topology on deformation:sharp-edged gratings generate localized shear forces surpassing those from homogeneous strain fields via smooth CD molds,triggering dislocation tangle formation,lattice reorientation,and inhomogeneous plastic deformation.Asymmetrical strain configurations enable localized structural transformations while retaining single-crystal integrity in adjacent regions—a balance essential for functional device integration.These insights position LSI as a precision tool for nanoscale strain engineering,capable of sculpting 2D material morphologies without compromising crystallinity.By bridging ultrafast mechanics with chiral chain material science,this work advances the design of strain-tunable devices for next-generation electronics and optoelectronics,while establishing a universal framework for manipulating anisotropic 2D systems under extreme strain rates.This work discovered crystallographic orientation-dependent deformation mechanisms in 2D Te,linking parallel strain to chain gliding and transverse strain to shear-driven multimodal distortion.It demonstrates mold geometry as a critical lever for strain localization and dislocation dynamics,with sharp-edged gratings enabling unprecedented control over lattice reorientation.Crucially,the identification of strain field conditions that reconcile severe plastic deformation with single-crystal retention offers a pathway to functional nanostructure fabrication,redefining LSI’s potential in ultrafast strain engineering of chiral chain materials.
文摘The concept of Supply Chain 4.0 represents a transformative phase in supply chain management through advanced digital technologies like IoT, AI, blockchain, and cyber-physical systems. While these innovations deliver operational improvements, the heightened interconnectivity introduces significant cybersecurity challenges, particularly within military logistics, where mission-critical operations and life-safety concerns are paramount. This paper examines these unique cybersecurity requirements, focusing on advanced persistent threats, supply chain poisoning, and data breaches that could compromise sensitive operations. The study proposes a hybrid cybersecurity framework tailored to military logistics, integrating resilience, redundancy, and cross-jurisdictional security measures. Real-world applicability is validated through simulations, offering strategies for securing supply chains while balancing security, efficiency, and flexibility.
文摘Amid the escalating plastic pollution issue, the development of biodegradable and recyclable polymeric materials has become a focus within the scientific community. Chain extenders, which are an important class of compounds, facilitate the elongation of polymer chains through reactive functional groups, thereby enhancing the performance of the materials. Epoxy-based chain extenders, due to their cost-effectiveness, low toxicity, high reaction efficiency, and effective reactivity with hydroxyl and carboxyl groups, have emerged as a promising class of chain extenders. This manuscript comprehensively elaborates on the varieties, structural characteristics, and performance of chain extenders, the challenges they face, and the methods for their modification. Special emphasis is placed on the application of epoxy-based chain extenders in biodegradable polymers, such as polylactic acid (PLA), and their subsequent influence on the structural and performance properties of these materials.
基金Supported by the National Natural Science Foundation of China(62462036,62262031)Jiangxi Provincial Natural Science Foundation(20242BAB26017,20232BAB202010)+1 种基金Distinguished Youth Fund Project of the Natural Science Foundation of Jiangxi Province(20242BAB23011)the Jiangxi Province Graduate Innovation Found Project(YJS2023032)。
文摘Control Flow Graphs(CFGs)are essential for understanding the execution and data flow within software,serving as foundational structures in program analysis.Traditional CFG construction methods,such as bytecode analysis and Abstract Syntax Trees(ASTs),often face challenges due to the complex syntax of programming languages like Java and Python.This paper introduces a novel approach that leverages Large Language Models(LLMs)to generate CFGs through a methodical Chain of Thought(CoT)process.By employing CoT,the proposed approach systematically interprets code semantics directly from natural language,enhancing the adaptability across various programming languages and simplifying the CFG construction process.By implementing a modular AI chain strategy that adheres to the single responsibility principle,our approach breaks down CFG generation into distinct,manageable steps handled by separate AI and non-AI units,which can significantly improve the precision and coverage of CFG nodes and edges.The experiments with 245 Java and 281 Python code snippets from Stack Overflow demonstrate that our method achieves efficient performance on different programming languages and exhibits strong robustness.
基金supported by the National Natural Science Foundation of China(Nos.U2244227,U2244226,42177172)the National Key R&D Program of China(No.2022YFC3004301)China Geological Survey Project(No.DD20230538)。
文摘Frequent glacier-related watershed geohazard chains are causing severe damage to life and infrastructure,reported consistently from the Eastern Himalayan Syntaxis.This paper presents a systematic method for researching geohazard,from regional to individual scale.The methodology includes the establishment of geological chain inventories,discrimination of geohazard chain modes,analyses of dynamics and dam breaches,and risk assessments.The following results were obtained:(1)In the downstream of Yarlung Zangbo River,175 sites were identified as high-risk for river blockage disasters,indicating the development of watershed geohazards.Five geohazard chain modes were summarized by incorporating geomorphological characteristics,historical events,landslide zoning,and materials.The risk areas of typical hazard were identified and assessed using InSAR data.(2)Glacier-related watershed geohazard chains are significantly different from traditional landslides.A detailed inversion analysis was conducted on the massive rock-ice avalanche in the Sedongpu gully in 2021.This particular event lasted roughly 300 seconds,with a maximum flow velocity of 77.2 m/s and a maximum flow height of 93 meters.By scrutinizing the dynamic processes and mechanical characteristics,mobility stages and phase transitions can be divided into four stages.(3)Watershed geohazard chains tend to block rivers.The peak breach discharge of the Yigong Landslide reached 12.4×10^(4) m^(3)/s,which is 36 times the volume of the seasonal flood discharge in the Yigong River.Megafloods caused by landslide dam breaches have significantly shaped the geomorphology.This study offers insights into disaster patterns and the multistaged movement characteristics of glacier-related watershed geohazard chains,providing a comprehensive method for investigations and assessments in glacial regions.
基金funded by the Sichuan Science and Technology Program,Grant Nos.2024NSFSC0515,2024ZHCG0182 and MZGC20230013.
文摘To solve the challenges of connecting and coordinating multiple platforms in the automotive industry and to enhance collaboration among different participants,this research focuses on addressing the complex supply relationships in the automotive market,improving data sharing and interactions across various platforms,and achieving more detailed integration of data and operations.We propose a trust evaluation permission delegation method based on the automotive industry chain.The proposed method combines smart contracts with trust evaluation mechanisms,dynamically calculating the trust value of users based on the historical behavior of the delegated entity,network environment,and other factors to avoid malicious node attacks during the permission delegation process.We also introduce strict control over the cross-domain permission granting and revocation mechanisms to manage the delegation path,prevent information leakage caused by malicious node interception,and effectively protect data integrity and privacy.Experimental analysis shows that this method meets the realtime requirements of collaborative interaction in the automotive industry chain and provides a feasible solution to permission delegation issues in the automotive industry chain,offering dynamic flexibility in authorization and scalability compared to most existing solutions.
文摘In response to the challenges presented by the unreliable identity of the master node,high communication overhead,and limited network support size within the Practical Byzantine Fault-Tolerant(PBFT)algorithm for consortium chains,we propose an improved PBFT algorithm based on XGBoost grouping called XG-PBFT in this paper.XG-PBFT constructs a dataset by training important parameters that affect node performance,which are used as classification indexes for nodes.The XGBoost algorithm then is employed to train the dataset,and nodes joining the system will be grouped according to the trained grouping model.Among them,the nodes with higher parameter indexes will be assigned to the consensus group to participate in the consensus,and the rest of the nodes will be assigned to the general group to receive the consensus results.In order to reduce the resource waste of the system,XG-PBFT optimizes the consensus protocol for the problem of high complexity of PBFT communication.Finally,we evaluate the performance of XG-PBFT.The experimental results show that XG-PBFT can significantly improve the performance of throughput,consensus delay and communication complexity compared to the original PBFT algorithm,and the performance enhancement is significant compared to other algorithms in the case of a larger number of nodes.The results demonstrate that the XG-PBFT algorithm is more suitable for large-scale consortium chains.
基金supported by the Major Subject of the National Social Science Foundation of China(21&ZD093)the Basic Research Funds of Chinese Academy of Agricultural Sciences(16100520240017)+1 种基金the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAASCSAERD-202402,10-IAED-04-2024)the earmarked fund for China Agriculture Research System(CARS-08).
文摘The Regional Comprehensive Economic Partnership(RCEP)has created favorable conditions for building deeply integrated agricultural value chains(AVC)in Asia-Pacific.Based on the RCEP agreement,this study employed the global trade analysis project(GTAP)model to evaluate the impact of RCEP on AVC of member countries in terms of time,tariff reduction,and reduction of non-tariff barriers(NTB).The results indicate that(1)the implementation of RCEP boosts the value-added to agricultural exports for most member countries,particularly in competitive industries;(2)the increase in domestic production and processing capacity,reflected in domestic value-added(DVA),is the primary factor driving the rise in the value-added of agricultural exports across various industries of member countries;(3)RCEP enhances the participation of most regional countries in AVC,with varying impacts on AVC positioning,thereby fostering regional AvC development;and(4)RCEP has a positive effect on AVC indicators both in the short and long term,with the effect becoming more pronounced over time.Additionally,reducing NTB enhances the positive effects of tariff reductions on AVC indicators.Based on the analyses,the following recommendations are proposed:(1)Leverage the development opportunities arising from RCEP implementation to enhance the agricultural DVA;(2)capitalize on cooperative opportunities created by RCEP to build cohesive regional AVC;and(3)prioritize the effective implementation of RCEP'shigh-qualityrules.
基金financially supported by the Sichuan Science and Technology Program(No.2024ZDZX0036)the National Ten Thousand Talent Plans for Young Top-notch Talents,and the National Natural Science Foundation of China(No.52021001).
文摘The rapid advancement of radar and 5 G communication technologies has created an urgent need for materials that possess both low dielectric constants and superior mechanical strength to ensure efficient signal transmission and minimal loss.Herein,a synergistic effect of multiple regulation strategies from the atomic scales to the molecular scales was proposed to develop Covalent Organic Frameworks(COFs)modified cyanate ester resins(COF-mCE).The strategy has proven highly effective in enhancing both dielectric and mechanical properties.With only 3 wt%COFs,the dielectric constant of COF-mCE is reduced from 3.32 to 2.84 at 1 MHz.Meanwhile,the mechanical performance of COF-mCE composites exhibits substantial improvements,with flexural strength increasing by 42.6% and tensile strength by 52.1% compared to pure mCE.The investigation explores that hydrogen bonding and π-π stacking interactions restrain the polarization feature and the mechanical property improvements of the COF-mCE derived from the entanglement effect of COF-polymer chains.Furthermore,the 3D-printed COF-mCE honeycomb structure demonstrates excellent electromagnetic wave transmittance and low reflectance,achieving a transmittance of 94.1% at 10 GHz with a 60°incidence angle.This multi-scale design strategy offers new insights into the development of low-k dielectric material for next-generation electronic science applications.
基金supported by a National Research Foundation of Korea(NRF)Grant funded by the Ministry of Science and ICT(2021R1A2C1014294,2022R1A2C3003319)the BK21 FOUR(Fostering Outstanding Universities for Research)through the National Research Foundation(NRF)of Korea.
文摘A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety problems.Our study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves conductivity.mPR-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain dispersion.Integrating this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 cycles.In situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen reactions.Ex situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability tests.The present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.
基金support from the National Natural Science Foundation of China(U20A20112,42061160480,42377196,and 52479095)the NSFC/RGC Joint Research Scheme(42061160480 and N_HKUST620/20)+1 种基金the Research Grants Council of the Hong Kong SAR Government(16203720,T22-606/23-R,and JRFS25266S09)the Project of Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone(HZQB-KCZYB-2020083)。
文摘A glacier hazard chain can form a long-runout mass flow and generate a large flood,affecting downstream areas hundreds of kilometers away from the initiating hazard site.This study focuses on the Yarlung Zangbo Daxiagu.The objective is to address two key unresolved issues:the evolution of detached glacier materials into debris flows or debris floods and the amplification of the impact range and threats.A comprehensive framework is developed that considers the impacts of near-field and far-field hazards.Numerical modeling,remote sensing,and field investigations were integrated to understand the interactions,transformations,and amplifications of hazards in the glacier hazard chain.The results indicate that extensive,nearly saturated sediments on the glacier valley floor,when entrained,amplify the magnitude of the mass flow.The topography plays a crucial role.When the valley outlet is perpendicular to the river course,topographic obstacles cause immediate halting,resulting in the formation of high barrier dams.Conversely,when the glacier valley aligns nearly parallel to the river course,the mass flow can travel a much longer distance upon entering the river,causing an enlarged affected area.The barrier dams can breach rapidly,causing breaching floods that amplify the downstream impact from several kilometers to hundreds of kilometers.Our analysis reveals that the overall impacts remain spatially limited.Specifically,downstream areas along the Yarlung Zangbo-Brahmaputra River are unlikely to face greater threats from the upstream floods than local monsoon floods.Our findings provide the foundation for the management of glacier hazard chains.
文摘The philosophical concept of one bond connecting the world is an established scientific and economic phenomenon today.The global industrial and supply chains are symbols of that universal link of fraternity,cooperation and globalization.Despite a few major economies still trying to push forward a decoupling agenda and favoring a“small yard,high fence”strategy,globalization and cooperation remain a global trend.
文摘Global coffee giant Starbucks has been rooted in the Chinese market for 26 years,committed to bringing high-quality products and excellent experiences to consumers.As an“old friend”of the China International Supply Chain Expo(herei naf ter refer red to as the“CISCE”),Starbucks has participated in this event for two consecutive years and will draw a blueprint for the sustainable development of the coffee industry from the perspective of building a green industrial and supply chain at the 3rd CISCE.
文摘As there are numerous challenges to the global industrial and supply chains,the China International Supply Chain Expo(hereinafter referred to as the“CISCE”)hosted by the China Council for the Promotion of International Trade(CCPIT),has been playing a unique role as a“stabilizer”for international cooperation,an“accelerator”for economic development,and a“booster”for future transformation.
基金financially supported by"Pioneer"and"Leading Goose"R&D Program of Zhejiang(No.2023C03130)the National Natural Science Foundation of China(No.22373029)+1 种基金Interdisciplinary Research Project of Hangzhou Normal University(No.2024JCXK02)Open Project Program of Key Laboratory of Yarn Materials Forming and Composite Processing Technology of Zhejiang Province(No.MTC2022-09)。
文摘An efficient strategy has been developed to reconstruct chain folding and traversing of poly(L-lactide)(PLLA)during melt crystallization based on the selective hydrolysis of its amorphous regions.The molecular weights of the pristine PLLA(crystalline part),single stem,and single cluster were determined by gel permeation chromatography(GPC)according to their evolution during alkali hydrolysis.The maximum-folding-number(in a single cluster)and minimum-cluster-number(in one polymer chain)were obtained using these molecular weights.With the help of two numbers,the chain folding and traversing during the melt crystallization process(at 120℃)of PLLA can be described as follows.Statistically,in a single polymer chain,there are at least 2 clusters consisting of up to 6.5 stems in each of them,while the rest of the polymer chain contributes to amorphous regions.Our results provide a new strategy for the investigation and fundamental understanding of the melt crystallization of PLLA.
文摘The China International Supply Chain Expo is an important window through which to observe the trends of China's supply chain transformation.GEOPOLITICAL unrest,climate change challenges,and advances in digital technology have reshaped the global supply chain in recent years.
文摘A substantial body of research has been conducted with the objective of enhancing the understanding of Non-Timber Forest Products (NTFP) in Central Africa. A significant proportion of the studies focus on medicinal plants, in contrast to those that examine food products. Nevertheless, studies on edible wild mushrooms as NTFPs and cultivated mushrooms, on their economic potential and value chains in the Great Lakes Region, remain scarce and largely absent for some NTFPs. In light of the aforementioned considerations, the present study aims to examine the economic potential and value chain of the production sector of wild edible mushrooms (WEM) and cultivated mushrooms (CM) within the Virunga National Park (PNVi) and its surrounding areas in North Kivu, Democratic Republic of the Congo (DRC). To this end, a sample of 432 respondents was selected, distributed equitably among the actors of the Goma-Kitshanga-Mweso value chain, the Goma-Rutshuru chain, the Beni-Mutwanga chain, and the Beni-Mangina chain. A digital questionnaire consisting of open and closed questions was administered, and observations were carried out concurrently. The quantities of mushrooms sold were weighed and photographed. The results demonstrated that, when the eight-month fruiting period of wild and cultivated mushrooms was considered as a single year for all actors within the value chain, a picker could sell 6.1 kg at $2 and earn $12. A seller could sell 16 kg at $4 and earn $64, while a grower could sell 502 kg at $3 and earn $1506. Consequently, the CM grower generates a significantly higher profit than other participants in the value chain, despite the expenses he incurs. Ultimately, the domestication of WEM, highly prized by the local population of the Virunga National Park, has the potential to enhance their household incomes, as evidenced by the findings of this study.
基金supported by the National Natural Science Foundation of China(Grant Nos.92365202,12475011,and 11921005)the National Key R&D Program of China(Grant No.2024YFA1409002)Shanghai Municipal Science and Technology Major Project(Grant No.2019SHZDZX01)。
文摘We investigate the mixed-state entanglement between two spins embedded in the XXZ Heisenberg chain under thermal equilibrium.By deriving an analytical expression for the entanglement of two-spin thermal states and extending this analysis to larger spin chains,we demonstrate that mixed-state entanglement is profoundly shaped by both disorder and temperature.Our results reveal a sharp distinction between many-body localized and ergodic phases,with entanglement vanishing above diferent fnite temperature thresholds.Furthermore,by analyzing non-adjacent spins,we uncover an approximate exponential decay of entanglement with separation.This work advances the understanding of the quantum-to-classical transition by linking the entanglement properties of small subsystems to the broader thermal environment,ofering an explanation for the absence of entanglement in macroscopic systems.These fndings provide critical insights into quantum many-body physics,bridging concepts from thermalization,localization,and quantum information theory.
基金financially supported by the National Key R&D Program of China(No.2019YFC1906600)the National Natural Science Foundation of China(No.52000132).
文摘Microbial chain elongation(CE),utilizing anaerobic fermentation for the synthesis of high-value medium chain fatty acids(MCFAs),merges as a promising strategy in resource sustainability.Recently,it has pivoted that the use of different types of additives or accelerantstowards enhancing the products yield and fermentation quality has got much attention,with carbon-based materials emerging as vital facilitators.Based on bibliometrics insights,this paper firstly commences with a comprehensive review of the past two decades’progress in applying carbon-based materials within anaerobic fermentation contexts.Subsequently,the recent advancements made by different research groups in order to enhance the performance of CE systemperformance are reviewed,with particular focus on the application,impact,and underlying mechanisms of carbon-based materials in expediting MCFAs biosynthesis via CE.Finally,the future research direction is prospected,aiming to inform innovative material design and sophisticated technological applications,as well as provide a reference for improving the efficiency of anaerobic fermentation of MCFAs using carbon-based material,thereby contributing to the broader discourse on enhancing sustainability and efficiency in bio-based processes.
