Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
Malignant pleural effusion(MPE) is a serious disease caused by malignant tumors with high morbidity and mortality.Chemotherapy,immunotherapy,and antiangiogenic therapy are common treatments for MPE at present.However,...Malignant pleural effusion(MPE) is a serious disease caused by malignant tumors with high morbidity and mortality.Chemotherapy,immunotherapy,and antiangiogenic therapy are common treatments for MPE at present.However,traditional chemotherapeutic drugs have many side effects and can easily lead to drug resistance in patients.The complex tumor microenvironment(TME) of MPE directly reduces the antitumor efficacy of immunotherapy.Fortunately,drug delivery systems(DDSs) based on biomaterials have the ability to overcome some of the drawbacks of conventional treatments by improving drug stability,increasing the accuracy of tumor cell targeting,reducing toxic side effects,and remodeling TME,ultimately improving drug efficacy.Therefore,the purpose of this review is to provide an overview and discussion of the latest progress in biomaterial-based DDSs for the treatment of MPE.We discuss the application of biomaterials in the treatment of MPE from multiple perspectives,including chemotherapy,immunotherapy,combination therapy,and pleurodesis,where microspheres,cell membrane-derived microparticles(MPs),micelles,nanoparticles,and liposomes,are involved.The application of these biomaterials has been proven to have great potential in the treatment of MPE,providing a new idea for follow-up research.展开更多
Reliable detection of traffic signs and lights(TSLs)at long range and under varying illumination is essen-tial for improving the perception and safety of autonomous driving systems(ADS).Traditional object detection mo...Reliable detection of traffic signs and lights(TSLs)at long range and under varying illumination is essen-tial for improving the perception and safety of autonomous driving systems(ADS).Traditional object detection models often exhibit significant performance degradation in real-world environments characterized by high dynamic range and complex lighting conditions.To overcome these limitations,this research presents FED-YOLOv10s,an improved and lightweight object detection framework based on You Only look Once v10(YOLOv10).The proposed model integrates a C2f-Faster block derived from FasterNet to reduce parameters and floating-point operations,an Efficient Multiscale Attention(EMA)mechanism to improve TSL-invariant feature extraction,and a deformable Convolution Networks v4(DCNv4)module to enhance multiscale spatial adaptability.Experimental findings demonstrate that the proposed architecture achieves an optimal balance between computational efficiency and detection accuracy,attaining an F1-score of 91.8%,and mAP@0.5 of 95.1%,while reducing parameters to 8.13 million.Comparative analyses across multiple traffic sign detection benchmarks demonstrate that FED-YOLOv10s outperforms state-of-the-art models in precision,recall,and mAP.These results highlight FED-YOLOv10s as a robust,efficient,and deployable solution for intelligent traffic perception in ADS.展开更多
Each morning at Yangluo Port in Wuhan,Hubei Province,the all-electric cargo vessel Huahang Xinneng No.1 completes a battery swap in under 10 minutes before returning to service with nearly 8,000 kWh of power onboard。
Curtain wall systems have evolved from aesthetic facade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness.This reviewpresents a comprehensive exa...Curtain wall systems have evolved from aesthetic facade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness.This reviewpresents a comprehensive examination of curtain walls from an energy-engineering perspective,highlighting their structural typologies(Stick and Unitized),material configurations,and integration with smart technologies such as electrochromic glazing,parametric design algorithms,and Building Management Systems(BMS).Thestudy explores the thermal,acoustic,and solar performance of curtain walls across various climatic zones,supported by comparative analyses and iconic case studies including Apple Park,Burj Khalifa,and Milad Tower.Key challenges—including installation complexity,high maintenance costs,and climate sensitivity—are critically assessed alongside proposed solutions.A central innovation of this work lies in framing curtain walls not only as passive architectural elements but as dynamic interfaces that modulate energy flows,reduce HVAC loads,and enhance occupant comfort.The reviewed data indicate that optimized curtain wall configurations—especially those integrating electrochromic glazing and BIPV modules—can achieve annual energy consumption reductions ranging fromapproximately 5%to 27%,depending on climate,control strategy,and facade typology.The findings offer a valuable reference for architects,energy engineers,and decision-makers seeking to integrate high-performance facades into future-ready building designs.展开更多
Hydrogen,as a zero-carbon secondary energy carrier,provides a unified pathway for low-carbon energy transformation.In electro–hydrogen coupling systems(EHCSs),surplus renewable power is stored via water electrolysis ...Hydrogen,as a zero-carbon secondary energy carrier,provides a unified pathway for low-carbon energy transformation.In electro–hydrogen coupling systems(EHCSs),surplus renewable power is stored via water electrolysis and later reconverted to electricity using fuel cells or gas turbines,enhancing the system’s flexibility and reliability in support of deep decarbonization.This study constructs an electricity–hydrogen energy-recycling model based on a coupling relationship considering the bidirectional conversion between electricity and hydrogen.A multistage carbon-emission-reduction indicator constraint is also established.Additionally,the green-certificate and carbon trading markets are introduced to optimize equipment investment and operation costs while achieving carbon-emission reduction.A case study reveals that the proposed EHCS planning model effectively allocates carbon emissions across different system stages,while mitigating economic repercussions,thus ensuring closer alignment with China’s emission-reduction policies.Incorporating diverse market mechanisms significantly enhances the system’s economy and decision-making flexibility,particularly in addressing future challenges in the energy market.展开更多
The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can...The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness.Treatment options for retinal diseases are limited,and there is an urgent need for innovative therapeutic strategies.Cell and gene therapies are promising because of the efficacy of delivery systems that transport therapeutic genes to targeted retinal cells.Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration,potentially restoring vision.This review focuses on two principal categories of gene delivery vectors used in the treatment of retinal diseases:viral and non-viral systems.Viral vectors,including lentiviruses and adeno-associated viruses,exploit the innate ability of viruses to infiltrate cells,which is followed by the introduction of therapeutic genetic material into target cells for gene correction.Lentiviruses can accommodate exogenous genes up to 8 kb in length,but their mechanism of integration into the host genome presents insertion mutation risks.Conversely,adeno-associated viruses are safer,as they exist as episomes in the nucleus,yet their limited packaging capacity constrains their application to a narrower spectrum of diseases,which necessitates the exploration of alternative delivery methods.In parallel,progress has also occurred in the development of novel non-viral delivery systems,particularly those based on liposomal technology.Manipulation of the ratios of hydrophilic and hydrophobic molecules within liposomes and the development of new lipid formulations have led to the creation of advanced non-viral vectors.These innovative systems include solid lipid nanoparticles,polymer nanoparticles,dendrimers,polymeric micelles,and polymeric nanoparticles.Compared with their viral counterparts,non-viral delivery systems offer markedly enhanced loading capacities that enable the direct delivery of nucleic acids,mRNA,or protein molecules into cells.This bypasses the need for DNA transcription and processing,which significantly enhances therapeutic efficiency.Nevertheless,the immunogenic potential and accumulation toxicity associated with non-viral particulate systems necessitates continued optimization to reduce adverse effects in vivo.This review explores the various delivery systems for retinal therapies and retinal nerve regeneration,and details the characteristics,advantages,limitations,and clinical applications of each vector type.By systematically outlining these factors,our goal is to guide the selection of the optimal delivery tool for a specific retinal disease,which will enhance treatment efficacy and improve patient outcomes while paving the way for more effective and targeted therapeutic interventions.展开更多
A flame length optimization scheme is proposed for multi-antenna downlink systems to guarantee diverse delay- bound violation probability constraints. Due to the difficulties of extracting the quality of service （QoS...A flame length optimization scheme is proposed for multi-antenna downlink systems to guarantee diverse delay- bound violation probability constraints. Due to the difficulties of extracting the quality of service （QoS） metrics from the conventional physical-layer channel models, the link-layer models named effective bandwidth and effective capacity are applied to statistically characterize the source traffic patterns and the queuing service dynamics. With these link-layer models, the source traffic process and the channel service process are mapped to certain QoS parameters. The packet delay-bound violation probability constraints are converted into minimum data rate constraints and the optimization problem is thus formulated into simultaneous inequalities. With the assumption of ergodic block-fading channels, the optimal frame lengths of single-user and multiuser systems are calculated respectively by numerical iterative methods. Theoretical analyses and simulation results show that the given delay-bound violation probability constraints are well satisfied with the optimal frame length.展开更多
With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenu...With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.展开更多
Transportation systems are experiencing a significant transformation due to the integration of advanced technologies, including artificial intelligence and machine learning. In the context of intelligent transportatio...Transportation systems are experiencing a significant transformation due to the integration of advanced technologies, including artificial intelligence and machine learning. In the context of intelligent transportation systems (ITS) and Advanced Driver Assistance Systems (ADAS), the development of efficient and reliable traffic light detection mechanisms is crucial for enhancing road safety and traffic management. This paper presents an optimized convolutional neural network (CNN) framework designed to detect traffic lights in real-time within complex urban environments. Leveraging multi-scale pyramid feature maps, the proposed model addresses key challenges such as the detection of small, occluded, and low-resolution traffic lights amidst complex backgrounds. The integration of dilated convolutions, Region of Interest (ROI) alignment, and Soft Non-Maximum Suppression (Soft-NMS) further improves detection accuracy and reduces false positives. By optimizing computational efficiency and parameter complexity, the framework is designed to operate seamlessly on embedded systems, ensuring robust performance in real-world applications. Extensive experiments using real-world datasets demonstrate that our model significantly outperforms existing methods, providing a scalable solution for ITS and ADAS applications. This research contributes to the advancement of Artificial Intelligence-driven (AI-driven) pattern recognition in transportation systems and offers a mathematical approach to improving efficiency and safety in logistics and transportation networks.展开更多
Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multip...Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multiple-Output(MIMO)Orthogonal Frequency Division Multiplexing(OFDM)signals as integrated signals and investigate the estimation performance of MIMO-OFDM signals.First,we analyze the Cramer-Rao Lower Bound(CRLB)of parameter estimation.Then,the transmit powers over different subcarriers are optimized to achieve the best tradeoff between the transmission rate and the estimation performance.Finally,we propose a more accurate estimation method that uses Canonical Polyadic Decomposition(CPD)of the third-order tensor to obtain the parameter matrices.Due to the characteristic of the column structure of the parameter matrices,we only need to use DFT/IDFT to recover the parameters of multiple targets.The simulation results show that tensor-based estimation method can achieve a performance close to CRLB,and the estimation performance can be improved by optimizing the transmit powers.展开更多
Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectiv...Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system.展开更多
Food systems are deeply affected by climate change and air pollution,while being key contributors to these environmental challenges.Understanding the complex interactions among food systems,climate change,and air poll...Food systems are deeply affected by climate change and air pollution,while being key contributors to these environmental challenges.Understanding the complex interactions among food systems,climate change,and air pollution is crucial for mitigating climate change,improving air quality,and promoting the sustainable development of food systems.However,the literature lacks a comprehensive review of these interactions,particularly in the current phase of rapid development in the field.To address this gap,this study systematically reviews recent research on the impacts of climate change and air pollution on food systems,as well as the greenhouse gas and air pollutant emissions from agri-food systems and their contribution to global climate change and air pollution.In addition,this study summarizes various strategies for mitigation and adaptation,including adjustments in agricultural practices and food supply chains.Profound changes in food systems are urgently needed to enhance adaptability and reduce emissions.This review offers a critical overview of current research on the interactions among food systems,climate change,and air pollution and highlights future research directions to support the transition to sustainable food systems.展开更多
In this paper,we investigate the distributed Nash equilibrium(NE)seeking problem for aggregative games with multiple uncertain Euler–Lagrange(EL)systems over jointly connected and weight-balanced switching networks.T...In this paper,we investigate the distributed Nash equilibrium(NE)seeking problem for aggregative games with multiple uncertain Euler–Lagrange(EL)systems over jointly connected and weight-balanced switching networks.The designed distributed controller consists of two parts:a dynamic average consensus part that asymptotically reproduces the unknown NE,and an adaptive reference-tracking module responsible for steering EL systems’positions to track a desired trajectory.The generalized Barbalat’s Lemma is used to overcome the discontinuity of the closed-loop system caused by the switching networks.The proposed algorithm is illustrated by a sensor network deployment problem.展开更多
This paper addresses the consensus problem of nonlinear multi-agent systems subject to external disturbances and uncertainties under denial-ofservice(DoS)attacks.Firstly,an observer-based state feedback control method...This paper addresses the consensus problem of nonlinear multi-agent systems subject to external disturbances and uncertainties under denial-ofservice(DoS)attacks.Firstly,an observer-based state feedback control method is employed to achieve secure control by estimating the system's state in real time.Secondly,by combining a memory-based adaptive eventtriggered mechanism with neural networks,the paper aims to approximate the nonlinear terms in the networked system and efficiently conserve system resources.Finally,based on a two-degree-of-freedom model of a vehicle affected by crosswinds,this paper constructs a multi-unmanned ground vehicle(Multi-UGV)system to validate the effectiveness of the proposed method.Simulation results show that the proposed control strategy can effectively handle external disturbances such as crosswinds in practical applications,ensuring the stability and reliable operation of the Multi-UGV system.展开更多
Cyber-physical systems(CPSs)are regarded as the backbone of the fourth industrial revolution,in which communication,physical processes,and computer technology are integrated.In modern industrial systems,CPSs are widel...Cyber-physical systems(CPSs)are regarded as the backbone of the fourth industrial revolution,in which communication,physical processes,and computer technology are integrated.In modern industrial systems,CPSs are widely utilized across various domains,such as smart grids,smart healthcare systems,smart vehicles,and smart manufacturing,among others.Due to their unique spatial distribution,CPSs are highly vulnerable to cyber-attacks,which may result in severe performance degradation and even system instability.Consequently,the security concerns of CPSs have attracted significant attention in recent years.In this paper,a comprehensive survey on the security issues of CPSs under cyber-attacks is provided.Firstly,mathematical descriptions of various types of cyberattacks are introduced in detail.Secondly,two types of secure estimation and control processing schemes,including robust methods and active methods,are reviewed.Thirdly,research findings related to secure control and estimation problems for different types of CPSs are summarized.Finally,the survey is concluded by outlining the challenges and suggesting potential research directions for the future.展开更多
As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy o...As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy.展开更多
Intelligent fault diagnosis technology plays an indispensable role in ensuring the safety,stability,and efficiency of railway operations.However,existing studies have the following limitations.1)They are typical black-...Intelligent fault diagnosis technology plays an indispensable role in ensuring the safety,stability,and efficiency of railway operations.However,existing studies have the following limitations.1)They are typical black-box models that lacks interpretability as well as they fuse features by simply stacking them,overlooking the discrepancies in the importance of different features,which reduces the credibility and diagnosis accuracy of the models.2)They ignore the effects of potentially mistaken labels in the training datasets disrupting the ability of the models to learn the true data distribution,which degrades the generalization performance of intelligent diagnosis models,especially when the training samples are limited.To address the above items,an interpretable few-shot framework for fault diagnosis with noisy labels is proposed for train transmission systems.In the proposed framework,a feature extractor is constructed by stacked frequency band focus modules,which can capture signal features in different frequency bands and further adaptively concentrate on the features corresponding to the potential fault characteristic frequency.Then,according to prototypical network,a novel metric-based classifier is developed that is tolerant to mislabeled support samples in the case of limited samples.Besides,a new loss function is designed to decrease the impact of label mistakes in query datasets.Finally,fault simulation experiments of subway train transmission systems are designed and conducted,and the effectiveness as well as superiority of the proposed method are proved by ablation experiments and comparison with the existing methods.展开更多
As one of the most classical scheduling problems,flexible job shop scheduling problems(FJSP)find widespread applications in modern intelligent manufacturing systems.However,the majority of meta-heuristic methods for s...As one of the most classical scheduling problems,flexible job shop scheduling problems(FJSP)find widespread applications in modern intelligent manufacturing systems.However,the majority of meta-heuristic methods for solving FJSP in the literature are population-based evolutionary algorithms,which are complex and time-consuming.In this paper,we propose a fast effective singlesolution based local search algorithm with an innovative adaptive weighting-based local search(AWLS)technique for solving FJSP.The adaptive weighting technique assigns weights to each operation and adaptively updates them during the exploration.AWLS integrates a Tabu Search strategy and the adaptive weighting technique to smooth the landscape of the search space and enhance the exploration diversity.Computational experiments on 313 well-known benchmark instances demonstrate that AWLS is highly competitive with state-of-the-art algorithms in terms of both solution quality and computational efficiency,despite of its simplicity.Specifically,AWLS improves the previous best-known results in the literature on 33 instances and match the best-known results on the remaining ones except for only one under the same time limit of up to 300 s.As a strongly non-deterministic polynomia(NP)-hard problem which has been extensively studied for nearly half a century,breaking the records on these classic instances is an arduous task.Nevertheless,AWLS establishes new records on 8 challenging instances whose previous best records were established by a state-of-the-art meta-heuristic algorithm and a famous industrial solver.展开更多
Traditional Chinese medicine(TCM)represents a paradigmatic approach to personalized medicine,developed through the systematic accumulation and refinement of clinical empirical data over more than 2000 years,and now en...Traditional Chinese medicine(TCM)represents a paradigmatic approach to personalized medicine,developed through the systematic accumulation and refinement of clinical empirical data over more than 2000 years,and now encompasses large-scale electronic medical records(EMR)and experimental molecular data.Artificial intelligence(AI)has demonstrated its utility in medicine through the development of various expert systems(e.g.,MYCIN)since the 1970s.With the emergence of deep learning and large language models(LLMs),AI’s potential in medicine shows considerable promise.Consequently,the integration of AI and TCM from both clinical and scientific perspectives presents a fundamental and promising research direction.This survey provides an insightful overview of TCM AI research,summarizing related research tasks from three perspectives:systems-level biological mechanism elucidation,real-world clinical evidence inference,and personalized clinical decision support.The review highlights representative AI methodologies alongside their applications in both TCM scientific inquiry and clinical practice.To critically assess the current state of the field,this work identifies major challenges and opportunities that constrain the development of robust research capabilities—particularly in the mechanistic understanding of TCM syndromes and herbal formulations,novel drug discovery,and the delivery of high-quality,patient-centered clinical care.The findings underscore that future advancements in AI-driven TCM research will rely on the development of high-quality,large-scale data repositories;the construction of comprehensive and domain-specific knowledge graphs(KGs);deeper insights into the biological mechanisms underpinning clinical efficacy;rigorous causal inference frameworks;and intelligent,personalized decision support systems.展开更多
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
基金financial support from the Noncommunicable Chronic Diseases-National Science and Technology Major Project (Nos.2024ZD0522800,2024ZD0522803)the National Natural Science Foundation of China (Nos.U21A20417,31930067,31800797)+2 种基金the Natural Science Foundation of Sichuan Province (No.2024NSFSC0046)the Sichuan Science and Technology Program (No.2022YFS0333)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University (No.ZYGD24003)。
文摘Malignant pleural effusion(MPE) is a serious disease caused by malignant tumors with high morbidity and mortality.Chemotherapy,immunotherapy,and antiangiogenic therapy are common treatments for MPE at present.However,traditional chemotherapeutic drugs have many side effects and can easily lead to drug resistance in patients.The complex tumor microenvironment(TME) of MPE directly reduces the antitumor efficacy of immunotherapy.Fortunately,drug delivery systems(DDSs) based on biomaterials have the ability to overcome some of the drawbacks of conventional treatments by improving drug stability,increasing the accuracy of tumor cell targeting,reducing toxic side effects,and remodeling TME,ultimately improving drug efficacy.Therefore,the purpose of this review is to provide an overview and discussion of the latest progress in biomaterial-based DDSs for the treatment of MPE.We discuss the application of biomaterials in the treatment of MPE from multiple perspectives,including chemotherapy,immunotherapy,combination therapy,and pleurodesis,where microspheres,cell membrane-derived microparticles(MPs),micelles,nanoparticles,and liposomes,are involved.The application of these biomaterials has been proven to have great potential in the treatment of MPE,providing a new idea for follow-up research.
基金funded by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,Saudi Arabia under Grant No.IPP:172-830-2025.
文摘Reliable detection of traffic signs and lights(TSLs)at long range and under varying illumination is essen-tial for improving the perception and safety of autonomous driving systems(ADS).Traditional object detection models often exhibit significant performance degradation in real-world environments characterized by high dynamic range and complex lighting conditions.To overcome these limitations,this research presents FED-YOLOv10s,an improved and lightweight object detection framework based on You Only look Once v10(YOLOv10).The proposed model integrates a C2f-Faster block derived from FasterNet to reduce parameters and floating-point operations,an Efficient Multiscale Attention(EMA)mechanism to improve TSL-invariant feature extraction,and a deformable Convolution Networks v4(DCNv4)module to enhance multiscale spatial adaptability.Experimental findings demonstrate that the proposed architecture achieves an optimal balance between computational efficiency and detection accuracy,attaining an F1-score of 91.8%,and mAP@0.5 of 95.1%,while reducing parameters to 8.13 million.Comparative analyses across multiple traffic sign detection benchmarks demonstrate that FED-YOLOv10s outperforms state-of-the-art models in precision,recall,and mAP.These results highlight FED-YOLOv10s as a robust,efficient,and deployable solution for intelligent traffic perception in ADS.
文摘Each morning at Yangluo Port in Wuhan,Hubei Province,the all-electric cargo vessel Huahang Xinneng No.1 completes a battery swap in under 10 minutes before returning to service with nearly 8,000 kWh of power onboard。
文摘Curtain wall systems have evolved from aesthetic facade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness.This reviewpresents a comprehensive examination of curtain walls from an energy-engineering perspective,highlighting their structural typologies(Stick and Unitized),material configurations,and integration with smart technologies such as electrochromic glazing,parametric design algorithms,and Building Management Systems(BMS).Thestudy explores the thermal,acoustic,and solar performance of curtain walls across various climatic zones,supported by comparative analyses and iconic case studies including Apple Park,Burj Khalifa,and Milad Tower.Key challenges—including installation complexity,high maintenance costs,and climate sensitivity—are critically assessed alongside proposed solutions.A central innovation of this work lies in framing curtain walls not only as passive architectural elements but as dynamic interfaces that modulate energy flows,reduce HVAC loads,and enhance occupant comfort.The reviewed data indicate that optimized curtain wall configurations—especially those integrating electrochromic glazing and BIPV modules—can achieve annual energy consumption reductions ranging fromapproximately 5%to 27%,depending on climate,control strategy,and facade typology.The findings offer a valuable reference for architects,energy engineers,and decision-makers seeking to integrate high-performance facades into future-ready building designs.
基金supported by State Grid Jiangsu Electric Power Co.,Ltd.Technology Project(Research on Planning and Operation Technology of Electric–Hydrogen Coupling System Driven by the Electric–Carbon–Green Certificate Market):J2024005.
文摘Hydrogen,as a zero-carbon secondary energy carrier,provides a unified pathway for low-carbon energy transformation.In electro–hydrogen coupling systems(EHCSs),surplus renewable power is stored via water electrolysis and later reconverted to electricity using fuel cells or gas turbines,enhancing the system’s flexibility and reliability in support of deep decarbonization.This study constructs an electricity–hydrogen energy-recycling model based on a coupling relationship considering the bidirectional conversion between electricity and hydrogen.A multistage carbon-emission-reduction indicator constraint is also established.Additionally,the green-certificate and carbon trading markets are introduced to optimize equipment investment and operation costs while achieving carbon-emission reduction.A case study reveals that the proposed EHCS planning model effectively allocates carbon emissions across different system stages,while mitigating economic repercussions,thus ensuring closer alignment with China’s emission-reduction policies.Incorporating diverse market mechanisms significantly enhances the system’s economy and decision-making flexibility,particularly in addressing future challenges in the energy market.
基金Hongguang Wu,Both authors contributed equally to this work and share first authorshipLing Dong,Both authors contributed equally to this work and share first authorship。
文摘The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness.Treatment options for retinal diseases are limited,and there is an urgent need for innovative therapeutic strategies.Cell and gene therapies are promising because of the efficacy of delivery systems that transport therapeutic genes to targeted retinal cells.Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration,potentially restoring vision.This review focuses on two principal categories of gene delivery vectors used in the treatment of retinal diseases:viral and non-viral systems.Viral vectors,including lentiviruses and adeno-associated viruses,exploit the innate ability of viruses to infiltrate cells,which is followed by the introduction of therapeutic genetic material into target cells for gene correction.Lentiviruses can accommodate exogenous genes up to 8 kb in length,but their mechanism of integration into the host genome presents insertion mutation risks.Conversely,adeno-associated viruses are safer,as they exist as episomes in the nucleus,yet their limited packaging capacity constrains their application to a narrower spectrum of diseases,which necessitates the exploration of alternative delivery methods.In parallel,progress has also occurred in the development of novel non-viral delivery systems,particularly those based on liposomal technology.Manipulation of the ratios of hydrophilic and hydrophobic molecules within liposomes and the development of new lipid formulations have led to the creation of advanced non-viral vectors.These innovative systems include solid lipid nanoparticles,polymer nanoparticles,dendrimers,polymeric micelles,and polymeric nanoparticles.Compared with their viral counterparts,non-viral delivery systems offer markedly enhanced loading capacities that enable the direct delivery of nucleic acids,mRNA,or protein molecules into cells.This bypasses the need for DNA transcription and processing,which significantly enhances therapeutic efficiency.Nevertheless,the immunogenic potential and accumulation toxicity associated with non-viral particulate systems necessitates continued optimization to reduce adverse effects in vivo.This review explores the various delivery systems for retinal therapies and retinal nerve regeneration,and details the characteristics,advantages,limitations,and clinical applications of each vector type.By systematically outlining these factors,our goal is to guide the selection of the optimal delivery tool for a specific retinal disease,which will enhance treatment efficacy and improve patient outcomes while paving the way for more effective and targeted therapeutic interventions.
基金The National Science and Technology M ajor Project(No.2012ZX03004005-003)the National Natural Science Foundation of China(No.61171081,61201175)the Research Fund of National M obile Communications Research Laboratory of Southeast University(No.2014A03)
文摘A flame length optimization scheme is proposed for multi-antenna downlink systems to guarantee diverse delay- bound violation probability constraints. Due to the difficulties of extracting the quality of service （QoS） metrics from the conventional physical-layer channel models, the link-layer models named effective bandwidth and effective capacity are applied to statistically characterize the source traffic patterns and the queuing service dynamics. With these link-layer models, the source traffic process and the channel service process are mapped to certain QoS parameters. The packet delay-bound violation probability constraints are converted into minimum data rate constraints and the optimization problem is thus formulated into simultaneous inequalities. With the assumption of ergodic block-fading channels, the optimal frame lengths of single-user and multiuser systems are calculated respectively by numerical iterative methods. Theoretical analyses and simulation results show that the given delay-bound violation probability constraints are well satisfied with the optimal frame length.
基金Supported by Beijing Municipal Natural Science Foundation of China(Grant No.24JL002)China Postdoctoral Science Foundation(Grant No.2024M754054)+2 种基金National Natural Science Foundation of China(Grant No.52120105008)Beijing Municipal Outstanding Young Scientis Program of Chinathe New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.
基金funded by the Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia through research group No.(RG-NBU-2022-1234).
文摘Transportation systems are experiencing a significant transformation due to the integration of advanced technologies, including artificial intelligence and machine learning. In the context of intelligent transportation systems (ITS) and Advanced Driver Assistance Systems (ADAS), the development of efficient and reliable traffic light detection mechanisms is crucial for enhancing road safety and traffic management. This paper presents an optimized convolutional neural network (CNN) framework designed to detect traffic lights in real-time within complex urban environments. Leveraging multi-scale pyramid feature maps, the proposed model addresses key challenges such as the detection of small, occluded, and low-resolution traffic lights amidst complex backgrounds. The integration of dilated convolutions, Region of Interest (ROI) alignment, and Soft Non-Maximum Suppression (Soft-NMS) further improves detection accuracy and reduces false positives. By optimizing computational efficiency and parameter complexity, the framework is designed to operate seamlessly on embedded systems, ensuring robust performance in real-world applications. Extensive experiments using real-world datasets demonstrate that our model significantly outperforms existing methods, providing a scalable solution for ITS and ADAS applications. This research contributes to the advancement of Artificial Intelligence-driven (AI-driven) pattern recognition in transportation systems and offers a mathematical approach to improving efficiency and safety in logistics and transportation networks.
基金supported by the National Natural Science Foundation of China under grants 62072229,U1936201,62071220,61976113joint project of China Mobile Research Institute&X-NET。
文摘Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multiple-Output(MIMO)Orthogonal Frequency Division Multiplexing(OFDM)signals as integrated signals and investigate the estimation performance of MIMO-OFDM signals.First,we analyze the Cramer-Rao Lower Bound(CRLB)of parameter estimation.Then,the transmit powers over different subcarriers are optimized to achieve the best tradeoff between the transmission rate and the estimation performance.Finally,we propose a more accurate estimation method that uses Canonical Polyadic Decomposition(CPD)of the third-order tensor to obtain the parameter matrices.Due to the characteristic of the column structure of the parameter matrices,we only need to use DFT/IDFT to recover the parameters of multiple targets.The simulation results show that tensor-based estimation method can achieve a performance close to CRLB,and the estimation performance can be improved by optimizing the transmit powers.
基金supported in part by the National Natural Science Foundation of China(62173255,62188101)Shenzhen Key Laboratory of Control Theory and Intelligent Systems(ZDSYS20220330161800001)
文摘Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system.
基金supported by the National Natural Science Foundation of China(42277087,42130708,42471021,42277482,and 42361144876)the Natural Science Foundation of Guangdong Province(2024A1515012550)+3 种基金the Hainan Institute of National Park grant(KY-23ZK01)the Tsinghua Shenzhen International Graduate School Cross-disciplinary Research and Innovation Fund Research Plan(JC2022011)the Shenzhen Science and Technology Program(JCYJ20240813112106009 and ZDSYS20220606100806014)the Scientific Research Start-up Funds(QD2021030C)from Tsinghua Shenzhen International Graduate School。
文摘Food systems are deeply affected by climate change and air pollution,while being key contributors to these environmental challenges.Understanding the complex interactions among food systems,climate change,and air pollution is crucial for mitigating climate change,improving air quality,and promoting the sustainable development of food systems.However,the literature lacks a comprehensive review of these interactions,particularly in the current phase of rapid development in the field.To address this gap,this study systematically reviews recent research on the impacts of climate change and air pollution on food systems,as well as the greenhouse gas and air pollutant emissions from agri-food systems and their contribution to global climate change and air pollution.In addition,this study summarizes various strategies for mitigation and adaptation,including adjustments in agricultural practices and food supply chains.Profound changes in food systems are urgently needed to enhance adaptability and reduce emissions.This review offers a critical overview of current research on the interactions among food systems,climate change,and air pollution and highlights future research directions to support the transition to sustainable food systems.
基金supported by the Research Grants Council of the Hong Kong Special Administration Region under the Grant No.14201621。
文摘In this paper,we investigate the distributed Nash equilibrium(NE)seeking problem for aggregative games with multiple uncertain Euler–Lagrange(EL)systems over jointly connected and weight-balanced switching networks.The designed distributed controller consists of two parts:a dynamic average consensus part that asymptotically reproduces the unknown NE,and an adaptive reference-tracking module responsible for steering EL systems’positions to track a desired trajectory.The generalized Barbalat’s Lemma is used to overcome the discontinuity of the closed-loop system caused by the switching networks.The proposed algorithm is illustrated by a sensor network deployment problem.
基金The National Natural Science Foundation of China(W2431048)The Science and Technology Research Program of Chongqing Municipal Education Commission,China(KJZDK202300807)The Chongqing Natural Science Foundation,China(CSTB2024NSCQQCXMX0052).
文摘This paper addresses the consensus problem of nonlinear multi-agent systems subject to external disturbances and uncertainties under denial-ofservice(DoS)attacks.Firstly,an observer-based state feedback control method is employed to achieve secure control by estimating the system's state in real time.Secondly,by combining a memory-based adaptive eventtriggered mechanism with neural networks,the paper aims to approximate the nonlinear terms in the networked system and efficiently conserve system resources.Finally,based on a two-degree-of-freedom model of a vehicle affected by crosswinds,this paper constructs a multi-unmanned ground vehicle(Multi-UGV)system to validate the effectiveness of the proposed method.Simulation results show that the proposed control strategy can effectively handle external disturbances such as crosswinds in practical applications,ensuring the stability and reliable operation of the Multi-UGV system.
文摘Cyber-physical systems(CPSs)are regarded as the backbone of the fourth industrial revolution,in which communication,physical processes,and computer technology are integrated.In modern industrial systems,CPSs are widely utilized across various domains,such as smart grids,smart healthcare systems,smart vehicles,and smart manufacturing,among others.Due to their unique spatial distribution,CPSs are highly vulnerable to cyber-attacks,which may result in severe performance degradation and even system instability.Consequently,the security concerns of CPSs have attracted significant attention in recent years.In this paper,a comprehensive survey on the security issues of CPSs under cyber-attacks is provided.Firstly,mathematical descriptions of various types of cyberattacks are introduced in detail.Secondly,two types of secure estimation and control processing schemes,including robust methods and active methods,are reviewed.Thirdly,research findings related to secure control and estimation problems for different types of CPSs are summarized.Finally,the survey is concluded by outlining the challenges and suggesting potential research directions for the future.
基金funded by the National Key R&D Program of China,grant number 2019YFB1505400.
文摘As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy.
基金supported in part by the National Key R&D Program of China under Grant 2022YFB4300601in part by the State Key Laboratory of Advanced Rail Autonomous Operation under Grant RAO2023ZZ003.
文摘Intelligent fault diagnosis technology plays an indispensable role in ensuring the safety,stability,and efficiency of railway operations.However,existing studies have the following limitations.1)They are typical black-box models that lacks interpretability as well as they fuse features by simply stacking them,overlooking the discrepancies in the importance of different features,which reduces the credibility and diagnosis accuracy of the models.2)They ignore the effects of potentially mistaken labels in the training datasets disrupting the ability of the models to learn the true data distribution,which degrades the generalization performance of intelligent diagnosis models,especially when the training samples are limited.To address the above items,an interpretable few-shot framework for fault diagnosis with noisy labels is proposed for train transmission systems.In the proposed framework,a feature extractor is constructed by stacked frequency band focus modules,which can capture signal features in different frequency bands and further adaptively concentrate on the features corresponding to the potential fault characteristic frequency.Then,according to prototypical network,a novel metric-based classifier is developed that is tolerant to mislabeled support samples in the case of limited samples.Besides,a new loss function is designed to decrease the impact of label mistakes in query datasets.Finally,fault simulation experiments of subway train transmission systems are designed and conducted,and the effectiveness as well as superiority of the proposed method are proved by ablation experiments and comparison with the existing methods.
基金supported in part by the National Natural Science Foundation of China(NSFC)(62202192 and 72101094)the National Science Fund for Distinguished Young Scholars of China(51825502).
文摘As one of the most classical scheduling problems,flexible job shop scheduling problems(FJSP)find widespread applications in modern intelligent manufacturing systems.However,the majority of meta-heuristic methods for solving FJSP in the literature are population-based evolutionary algorithms,which are complex and time-consuming.In this paper,we propose a fast effective singlesolution based local search algorithm with an innovative adaptive weighting-based local search(AWLS)technique for solving FJSP.The adaptive weighting technique assigns weights to each operation and adaptively updates them during the exploration.AWLS integrates a Tabu Search strategy and the adaptive weighting technique to smooth the landscape of the search space and enhance the exploration diversity.Computational experiments on 313 well-known benchmark instances demonstrate that AWLS is highly competitive with state-of-the-art algorithms in terms of both solution quality and computational efficiency,despite of its simplicity.Specifically,AWLS improves the previous best-known results in the literature on 33 instances and match the best-known results on the remaining ones except for only one under the same time limit of up to 300 s.As a strongly non-deterministic polynomia(NP)-hard problem which has been extensively studied for nearly half a century,breaking the records on these classic instances is an arduous task.Nevertheless,AWLS establishes new records on 8 challenging instances whose previous best records were established by a state-of-the-art meta-heuristic algorithm and a famous industrial solver.
基金supported by the National Key Research and Development Program (No.2023YFC3502604)the National Natural Science Foundation of China (Nos.U23B2062, 82274352,82174533, 82374302, 82204941)+3 种基金the Noncommunicable Chronic Diseases-National Science and Technology Major Project (No.2023ZD0505700)the Beijing-Tianjin-Hebei Basic Research Cooperation Project (No.22JCZXJC00070)the State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (No.SKL2024Z0102)Key R&D project of Ningxia Autonomous Region (No.2022BEG02036).
文摘Traditional Chinese medicine(TCM)represents a paradigmatic approach to personalized medicine,developed through the systematic accumulation and refinement of clinical empirical data over more than 2000 years,and now encompasses large-scale electronic medical records(EMR)and experimental molecular data.Artificial intelligence(AI)has demonstrated its utility in medicine through the development of various expert systems(e.g.,MYCIN)since the 1970s.With the emergence of deep learning and large language models(LLMs),AI’s potential in medicine shows considerable promise.Consequently,the integration of AI and TCM from both clinical and scientific perspectives presents a fundamental and promising research direction.This survey provides an insightful overview of TCM AI research,summarizing related research tasks from three perspectives:systems-level biological mechanism elucidation,real-world clinical evidence inference,and personalized clinical decision support.The review highlights representative AI methodologies alongside their applications in both TCM scientific inquiry and clinical practice.To critically assess the current state of the field,this work identifies major challenges and opportunities that constrain the development of robust research capabilities—particularly in the mechanistic understanding of TCM syndromes and herbal formulations,novel drug discovery,and the delivery of high-quality,patient-centered clinical care.The findings underscore that future advancements in AI-driven TCM research will rely on the development of high-quality,large-scale data repositories;the construction of comprehensive and domain-specific knowledge graphs(KGs);deeper insights into the biological mechanisms underpinning clinical efficacy;rigorous causal inference frameworks;and intelligent,personalized decision support systems.
