Unwarranted death of neurons is a major cause of neurodegenerative diseases.Since mature neurons are postmitotic and do not replicate,their death usually constitutes an irreversible step in pathology.A logical strateg...Unwarranted death of neurons is a major cause of neurodegenerative diseases.Since mature neurons are postmitotic and do not replicate,their death usually constitutes an irreversible step in pathology.A logical strategy to prevent neurodegeneration would then be to save all neurons that are still alive,i.e.protecting the ones that are still healthy as well as trying to rescue the ones that are damaged and in the process of dying.Regarding the latter,recent experiments have indicated that the possibility of reversing the cell death process and rescuing dying cells is more significant than previously anticipated.In many situations,the elimination of the cell death trigger alone enables dying cells to spontaneously repair their damage,recover,and survive.In this review,we explore the factors,which determine the fate of neurons engaged in the cell death process.A deeper insight into cell death mechanisms and the intrinsic capacity of cells to recover could pave the way for novel therapeutic approaches to neurodegenerative diseases.展开更多
The aging process is an inexorable fact throughout our lives and is considered a major factor in develo ping neurological dysfunctions associated with cognitive,emotional,and motor impairments.Aging-associated neurode...The aging process is an inexorable fact throughout our lives and is considered a major factor in develo ping neurological dysfunctions associated with cognitive,emotional,and motor impairments.Aging-associated neurodegenerative diseases are characterized by the progressive loss of neuronal structure and function.展开更多
The paper presents a method of using single neuron adaptive PID control for adjusting system or servo system to implement timber drying process control, which combines the thought of parameter adaptive PID control and...The paper presents a method of using single neuron adaptive PID control for adjusting system or servo system to implement timber drying process control, which combines the thought of parameter adaptive PID control and the character of neural network on exactly describing nonlinear and uncertainty dynamic process organically. The method implements functions of adaptive and self-learning by adjusting weighting parameters. Adaptive neural network can make some output trail given hoping value to decouple in static state. The simulation result indicates the validity, veracity and robustness of the method used in the timber drying process展开更多
Many studies revealed unconscious effects on conscious processing. However, in this study, we tried to investigate whether unconscious processes could interact with each other by using simultaneously presented face pi...Many studies revealed unconscious effects on conscious processing. However, in this study, we tried to investigate whether unconscious processes could interact with each other by using simultaneously presented face pictures with the same or a different unconscious valence (SUV versus DUV). In the first event-related potential (ERP) study, DUV elicited a smaller N2 as compared with SUV. In the second functional magnetic resonance imaging (fMRI) experiment, the left middle frontal gyrus (MFG) was activated under DUV condition in comparison to SUV condition. These results support the idea of interactions between unconscious processes (unconscious mismatch detection). The theoretical implications are discussed in the light of the global neuronal workspace theory.展开更多
A filter algorithm based on cochlear mechanics and neuron filter mechanism is proposed from the view point of vibration.It helps to solve the problem that the non-linear amplification is rarely considered in studying ...A filter algorithm based on cochlear mechanics and neuron filter mechanism is proposed from the view point of vibration.It helps to solve the problem that the non-linear amplification is rarely considered in studying the auditory filters.A cochlear mechanical transduction model is built to illustrate the audio signals processing procedure in cochlea,and then the neuron filter mechanism is modeled to indirectly obtain the outputs with the cochlear properties of frequency tuning and non-linear amplification.The mathematic description of the proposed algorithm is derived by the two models.The parameter space,the parameter selection rules and the error correction of the proposed algorithm are discussed.The unit impulse responses in the time domain and the frequency domain are simulated and compared to probe into the characteristics of the proposed algorithm.Then a 24-channel filter bank is built based on the proposed algorithm and applied to the enhancements of the audio signals.The experiments and comparisons verify that,the proposed algorithm can effectively divide the audio signals into different frequencies,significantly enhance the high frequency parts,and provide positive impacts on the performance of speech enhancement in different noise environments,especially for the babble noise and the volvo noise.展开更多
Neuron PSD (proportion, sum and differentiation) controller has the ability of on-line change of weights to reach the purpose of regulating parameters of PID using neuron’s self-studying and self-organization and the...Neuron PSD (proportion, sum and differentiation) controller has the ability of on-line change of weights to reach the purpose of regulating parameters of PID using neuron’s self-studying and self-organization and the change of controlled plant, which overcomes the disadvantages of affecting a conventional PID’s accurate regulation because of the change of load, model and non-linearity. LF2407 DSP can reach the purpose of parallel running by using multi-sets of bus. So it can greatly increase operation speed and offer a set of flexible instruction system. The realization of PSD control on DSP can build an ideal electrical machine controller.展开更多
Based on the model of a formal neuron proposed by McCulloch and Pitts,a kind ofneural circuit,which is a CMOS Variable Threshold Logic(VTL)circuit,is given in this paperconsidering the features of the binary image pro...Based on the model of a formal neuron proposed by McCulloch and Pitts,a kind ofneural circuit,which is a CMOS Variable Threshold Logic(VTL)circuit,is given in this paperconsidering the features of the binary image processing system.The theoretical analysis,andthe simulations for the building block circuits such as D/A converters,comparator and so on aregiven.The layout design of the whole circuit are also given.The binary image processing can berealized by using the VTL circuit combined with its external auxiliary circuits.展开更多
The main classical schools of Chinese philosophy can be characterized as process thinking and their concepts are related to those of Whitehead＇s philosophy of organism. （Neo-）Confucianism, Daoism, and Chinese Buddh...The main classical schools of Chinese philosophy can be characterized as process thinking and their concepts are related to those of Whitehead＇s philosophy of organism. （Neo-）Confucianism, Daoism, and Chinese Buddhism all find their roots in the Yi ding with a strong emphasis on human experience of the flux of time. These Eastern and Western world views allow attempts to consciously experience experiential reality in terms of immanent transcendence. These attempts are discussed also by considering the functioning of the human brain, emphasizing the importance of brain asymmetry.展开更多
In the present article, we argue that consciousness and body are not to be separate to explain the intentional consciousness of the human being facing to environment. 1) The most neurobiologist and neurocognitivist st...In the present article, we argue that consciousness and body are not to be separate to explain the intentional consciousness of the human being facing to environment. 1) The most neurobiologist and neurocognitivist studies suggest that the emerging consciousness appears to be a generic recurring process which subsumes under it the various results of scientist approaches. When analyzed with the cybernetic transductive method of Simondon, this process can be viewed as a noetico-neuronal unit which the sui generis activity can be boiled down to concept of intentional consciousness. 2) Homeostasis can be also metaphorically described as a generic recurring process which subsumes under it the myriad molecular feedback loops of organism. This self-regulating dynamic process could be governed by the cosmologic (Earth + Universe) production of entropy, which would keep high activity and dissipating energy and low internal entropy to maintain an ordering in the organic structure. 3) Based on numerous arguments and data, the cerebral noetico-neuronal process and the self-regulating homeostasic process may be viewed as an entire physiological (brain + body) system. We suggest that the whole (brain + body) has an intentional embodied consciousness that could be driven by the cosmologic production of entropy.展开更多
基金supported by the following foundations:“Stichting Oogfonds Nederland(No.2023-26)”the“Landelijke Stichting voor Blinden en Slechtzienden(No.2023-24)”that contributed through UitZicht,ZonMw grant(No.435005020)a grant of the Chinese Scholarship Council(No.201809110169)(to TGMFG,CPMR,and WY).
文摘Unwarranted death of neurons is a major cause of neurodegenerative diseases.Since mature neurons are postmitotic and do not replicate,their death usually constitutes an irreversible step in pathology.A logical strategy to prevent neurodegeneration would then be to save all neurons that are still alive,i.e.protecting the ones that are still healthy as well as trying to rescue the ones that are damaged and in the process of dying.Regarding the latter,recent experiments have indicated that the possibility of reversing the cell death process and rescuing dying cells is more significant than previously anticipated.In many situations,the elimination of the cell death trigger alone enables dying cells to spontaneously repair their damage,recover,and survive.In this review,we explore the factors,which determine the fate of neurons engaged in the cell death process.A deeper insight into cell death mechanisms and the intrinsic capacity of cells to recover could pave the way for novel therapeutic approaches to neurodegenerative diseases.
文摘The aging process is an inexorable fact throughout our lives and is considered a major factor in develo ping neurological dysfunctions associated with cognitive,emotional,and motor impairments.Aging-associated neurodegenerative diseases are characterized by the progressive loss of neuronal structure and function.
基金the Key Technologies R&D Program of Harbin (0111211102).
文摘The paper presents a method of using single neuron adaptive PID control for adjusting system or servo system to implement timber drying process control, which combines the thought of parameter adaptive PID control and the character of neural network on exactly describing nonlinear and uncertainty dynamic process organically. The method implements functions of adaptive and self-learning by adjusting weighting parameters. Adaptive neural network can make some output trail given hoping value to decouple in static state. The simulation result indicates the validity, veracity and robustness of the method used in the timber drying process
文摘Many studies revealed unconscious effects on conscious processing. However, in this study, we tried to investigate whether unconscious processes could interact with each other by using simultaneously presented face pictures with the same or a different unconscious valence (SUV versus DUV). In the first event-related potential (ERP) study, DUV elicited a smaller N2 as compared with SUV. In the second functional magnetic resonance imaging (fMRI) experiment, the left middle frontal gyrus (MFG) was activated under DUV condition in comparison to SUV condition. These results support the idea of interactions between unconscious processes (unconscious mismatch detection). The theoretical implications are discussed in the light of the global neuronal workspace theory.
基金Project(17KJB510029)supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions,ChinaProject(GXL2017004)supported by the Scientific Research Foundation of Nanjing Forestry University,China+3 种基金Project(202102210132)supported by the Important Project of Science and Technology of Henan Province,ChinaProject(B2019-51)supported by the Scientific Research Foundation of Henan Polytechnic University,ChinaProject(51521003)supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of ChinaProject(KQTD2016112515134654)supported by Shenzhen Science and Technology Program,China。
文摘A filter algorithm based on cochlear mechanics and neuron filter mechanism is proposed from the view point of vibration.It helps to solve the problem that the non-linear amplification is rarely considered in studying the auditory filters.A cochlear mechanical transduction model is built to illustrate the audio signals processing procedure in cochlea,and then the neuron filter mechanism is modeled to indirectly obtain the outputs with the cochlear properties of frequency tuning and non-linear amplification.The mathematic description of the proposed algorithm is derived by the two models.The parameter space,the parameter selection rules and the error correction of the proposed algorithm are discussed.The unit impulse responses in the time domain and the frequency domain are simulated and compared to probe into the characteristics of the proposed algorithm.Then a 24-channel filter bank is built based on the proposed algorithm and applied to the enhancements of the audio signals.The experiments and comparisons verify that,the proposed algorithm can effectively divide the audio signals into different frequencies,significantly enhance the high frequency parts,and provide positive impacts on the performance of speech enhancement in different noise environments,especially for the babble noise and the volvo noise.
文摘Neuron PSD (proportion, sum and differentiation) controller has the ability of on-line change of weights to reach the purpose of regulating parameters of PID using neuron’s self-studying and self-organization and the change of controlled plant, which overcomes the disadvantages of affecting a conventional PID’s accurate regulation because of the change of load, model and non-linearity. LF2407 DSP can reach the purpose of parallel running by using multi-sets of bus. So it can greatly increase operation speed and offer a set of flexible instruction system. The realization of PSD control on DSP can build an ideal electrical machine controller.
文摘Based on the model of a formal neuron proposed by McCulloch and Pitts,a kind ofneural circuit,which is a CMOS Variable Threshold Logic(VTL)circuit,is given in this paperconsidering the features of the binary image processing system.The theoretical analysis,andthe simulations for the building block circuits such as D/A converters,comparator and so on aregiven.The layout design of the whole circuit are also given.The binary image processing can berealized by using the VTL circuit combined with its external auxiliary circuits.
文摘The main classical schools of Chinese philosophy can be characterized as process thinking and their concepts are related to those of Whitehead＇s philosophy of organism. （Neo-）Confucianism, Daoism, and Chinese Buddhism all find their roots in the Yi ding with a strong emphasis on human experience of the flux of time. These Eastern and Western world views allow attempts to consciously experience experiential reality in terms of immanent transcendence. These attempts are discussed also by considering the functioning of the human brain, emphasizing the importance of brain asymmetry.
文摘In the present article, we argue that consciousness and body are not to be separate to explain the intentional consciousness of the human being facing to environment. 1) The most neurobiologist and neurocognitivist studies suggest that the emerging consciousness appears to be a generic recurring process which subsumes under it the various results of scientist approaches. When analyzed with the cybernetic transductive method of Simondon, this process can be viewed as a noetico-neuronal unit which the sui generis activity can be boiled down to concept of intentional consciousness. 2) Homeostasis can be also metaphorically described as a generic recurring process which subsumes under it the myriad molecular feedback loops of organism. This self-regulating dynamic process could be governed by the cosmologic (Earth + Universe) production of entropy, which would keep high activity and dissipating energy and low internal entropy to maintain an ordering in the organic structure. 3) Based on numerous arguments and data, the cerebral noetico-neuronal process and the self-regulating homeostasic process may be viewed as an entire physiological (brain + body) system. We suggest that the whole (brain + body) has an intentional embodied consciousness that could be driven by the cosmologic production of entropy.
