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Single-Cell and Multi-Dimensional Data Analysis of the Key Role of IDH2 in Cervical Squamous Cell Carcinoma Progression
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作者 Xiaojuan Liu Zhenpeng Zhu +5 位作者 Chenyang Hou Hui Ma Xiaoyan Li Chunxing Ma Lisha Shu Huiying Zhang 《Biomedical and Environmental Sciences》 2025年第6期773-778,共6页
Cervical cancer,a leading malignancy globally,poses a significant threat to women's health,with an estimated 604,000 new cases and 342,000 deaths reported in 2020^([1]).As cervical cancer is closely linked to huma... Cervical cancer,a leading malignancy globally,poses a significant threat to women's health,with an estimated 604,000 new cases and 342,000 deaths reported in 2020^([1]).As cervical cancer is closely linked to human papilloma virus(HPV)infection,early detection relies on HPV screening;however,late-stage prognosis remains poor,underscoring the need for novel diagnostic and therapeutic targets^([2]). 展开更多
关键词 cervical squamous cell carcinoma IDH cervical cancera multi dimensional data analysis novel diagnostic therapeutic targets cervical cancer prognosis human papilloma virus hpv infectionearly
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CDA-Net:Cross dimensional attention network for wetland bird detection
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作者 Jia'nan Lv Changchun Zhang +1 位作者 Jiangjian Xie Junguo Zhang 《Avian Research》 2026年第1期216-227,共12页
Monitoring waterbirds is vital for evaluating the ecological health of wetlands,and object detection offers an automated solution for identifying birds in monitoring imagery.However,conventional detection methods ofte... Monitoring waterbirds is vital for evaluating the ecological health of wetlands,and object detection offers an automated solution for identifying birds in monitoring imagery.However,conventional detection methods often overlook the multi-scale nature of bird targets,limiting their ability to capture rich contextual information across different scales.To address this,we propose a cross-dimensional attention network(CDA-Net)for bird detection that integrates spatial and channel information to improve species recognition.The proposed CDA-Net partitions feature maps into multiple channel wise sub-features.Spatial and channel attention are applied to each subfeature,and the resulting features are fused using the Hadamard product.The fused features are then forwarded to the detection head to generate the final detection results.This approach effectively captures and integrates information across spatial and channel dimensions.Experiments on our self-constructed Nanhai Wetland Waterbird Dataset and the public CUB-200-2011 dataset yield precision scores of 91.32%and 81.99%,respectively,outperforming existing methods.Our approach effectively handles scale variation in bird detection and provides a valuable tool for advancing automated wetland waterbird monitoring. 展开更多
关键词 Bird detection Channel and spatial attention Cross dimensional network Feature integration multi sizes object
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AI-driven integration of multi-omics and multimodal data for precision medicine
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作者 Heng-Rui Liu 《Medical Data Mining》 2026年第1期1-2,共2页
High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging ... High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1). 展开更多
关键词 high throughput transcriptomics multi omics single cell multimodal learning frameworks foundation models omics data modalitiesemerging ai driven precision medicine
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Single-Dimensional Encryption Against Stealthy Attacks on Stochastic Event-Based Estimation
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作者 Jun Shang Di Zhao +1 位作者 Hanwen Zhang Dawei Shi 《IEEE/CAA Journal of Automatica Sinica》 2026年第1期233-235,共3页
Dear Editor,This letter studies the problem of stealthy attacks targeting stochastic event-based estimation,alongside proposing measures for their mitigation.A general attack framework is introduced,and the correspond... Dear Editor,This letter studies the problem of stealthy attacks targeting stochastic event-based estimation,alongside proposing measures for their mitigation.A general attack framework is introduced,and the corresponding stealthiness condition is analyzed.To enhance system security,we advocate for a single-dimensional encryption method,showing that securing a singular data element is sufficient to shield the system from the perils of stealthy attacks. 展开更多
关键词 enhance system securitywe securing singular data element single dimensional encryption stochastic event based estimation stealthiness condition security mitigation attack framework stealthy attacks
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Equality and Inclusiveness&Harmonious Coexistence:Multi-dimensional Narratives of Civilisations from Writers'Perspective
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《International Understanding》 2025年第2期24-25,共2页
On the evening of May 3Oth,the parallel forum"Equality and Inclusiveness&Harmonious Coexistence:Multi-dimensional Narratives of Civilisations from Writers'Perspective",as part of the 4th Dialogue on ... On the evening of May 3Oth,the parallel forum"Equality and Inclusiveness&Harmonious Coexistence:Multi-dimensional Narratives of Civilisations from Writers'Perspective",as part of the 4th Dialogue on Exchanges and Mutual Learning among Civilisations,was held in Dunhuang.The forum was organised by the China Writers Association and co-organised by China National Publications Import&Export(Group)Corporation. 展开更多
关键词 INCLUSIVENESS dialogue EXCHANGES multi dimensional narratives civilisations writers perspective exchanges mutual learning EQUALITY
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Corrigendum to“Deep transfer learning for three-dimensional aerodynamic pressure prediction under data scarcity”[Theor.App.Mech.Lett.15(2025)100571]
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作者 Hao Zhang Yang Shen +2 位作者 Wei Huang Zan Xie Yao-bin Niu 《Theoretical & Applied Mechanics Letters》 2025年第6期630-630,共1页
The authors regret the following two errors.
关键词 deep transfer learning data scarcity three dimensional aerodynamic pressure prediction
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A theoretical study of the multigrid three-dimensional variational data assimilation scheme using a simple bilinear interpolation algorithm 被引量:5
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作者 LI Wei XIE Yuanfu HAN Guijun 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2013年第3期80-87,共8页
In order to solve the so-called "bull-eye" problem caused by using a simple bilinear interpolation as an observational mapping operator in the cost function in the multigrid three-dimensional variational (3DVAR) d... In order to solve the so-called "bull-eye" problem caused by using a simple bilinear interpolation as an observational mapping operator in the cost function in the multigrid three-dimensional variational (3DVAR) data assimilation scheme, a smoothing term, equivalent to a penalty term, is introduced into the cost function to serve as a means of troubleshooting. A theoretical analysis is first performed to figure out what on earth results in the issue of "bull-eye", and then the meaning of such smoothing term is elucidated and the uniqueness of solution of the multigrid 3DVAR with the smoothing term added is discussed through the theoretical deduction for one-dimensional (1D) case, and two idealized data assimilation experiments (one- and two-dimensional (2D) cases). By exploring the relationship between the smoothing term and the recursive filter theoretically and practically, it is revealed why satisfied analysis results can be achieved by using such proposed solution for the issue of the multigrid 3DVAR. 展开更多
关键词 multiGRID three-dimensional variational data assimilation bilinear interpolation
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Goodness-of-fit tests for multi-dimensional copulas:Expanding application to historical drought data 被引量:2
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作者 Ming-wei MA Li-liang REN +2 位作者 Song-bai SONG Jia-li SONG Shan-hu JIANG 《Water Science and Engineering》 EI CAS CSCD 2013年第1期18-30,共13页
The question of how to choose a copula model that best fits a given dataset is a predominant limitation of the copula approach, and the present study aims to investigate the techniques of goodness-of-fit tests for mul... The question of how to choose a copula model that best fits a given dataset is a predominant limitation of the copula approach, and the present study aims to investigate the techniques of goodness-of-fit tests for multi-dimensional copulas. A goodness-of-fit test based on Rosenblatt's transformation was mathematically expanded from two dimensions to three dimensions and procedures of a bootstrap version of the test were provided. Through stochastic copula simulation, an empirical application of historical drought data at the Lintong Gauge Station shows that the goodness-of-fit tests perform well, revealing that both trivariate Gaussian and Student t copulas are acceptable for modeling the dependence structures of the observed drought duration, severity, and peak. The goodness-of-fit tests for multi-dimensional copulas can provide further support and help a lot in the potential applications of a wider range of copulas to describe the associations of correlated hydrological variables. However, for the application of copulas with the number of dimensions larger than three, more complicated computational efforts as well as exploration and parameterization of corresponding copulas are required. 展开更多
关键词 goodness-of-fit test multi-dimensional copulas stochastic simulation Rosenblatt'stransformation bootstrap approach drought data
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Multidimensional Data Querying on Tree-Structured Overlay
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作者 XU Lizhen WANG Shiyuan 《Wuhan University Journal of Natural Sciences》 CAS 2006年第5期1367-1372,共6页
Multidimensional data query has been gaining much interest in database research communities in recent years, yet many of the existing studies focus mainly on ten tralized systems. A solution to querying in Peer-to-Pee... Multidimensional data query has been gaining much interest in database research communities in recent years, yet many of the existing studies focus mainly on ten tralized systems. A solution to querying in Peer-to-Peer(P2P) environment was proposed to achieve both low processing cost in terms of the number of peers accessed and search messages and balanced query loads among peers. The system is based on a balanced tree structured P2P network. By partitioning the query space intelligently, the amount of query forwarding is effectively controlled, and the number of peers involved and search messages are also limited. Dynamic load balancing can be achieved during space partitioning and query resolving. Extensive experiments confirm the effectiveness and scalability of our algorithms on P2P networks. 展开更多
关键词 range query skyline query P2P indexing multi-dimensional data partition
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Dimensionality Reduction of High-Dimensional Highly Correlated Multivariate Grapevine Dataset
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作者 Uday Kant Jha Peter Bajorski +3 位作者 Ernest Fokoue Justine Vanden Heuvel Jan van Aardt Grant Anderson 《Open Journal of Statistics》 2017年第4期702-717,共16页
Viticulturists traditionally have a keen interest in studying the relationship between the biochemistry of grapevines’ leaves/petioles and their associated spectral reflectance in order to understand the fruit ripeni... Viticulturists traditionally have a keen interest in studying the relationship between the biochemistry of grapevines’ leaves/petioles and their associated spectral reflectance in order to understand the fruit ripening rate, water status, nutrient levels, and disease risk. In this paper, we implement imaging spectroscopy (hyperspectral) reflectance data, for the reflective 330 - 2510 nm wavelength region (986 total spectral bands), to assess vineyard nutrient status;this constitutes a high dimensional dataset with a covariance matrix that is ill-conditioned. The identification of the variables (wavelength bands) that contribute useful information for nutrient assessment and prediction, plays a pivotal role in multivariate statistical modeling. In recent years, researchers have successfully developed many continuous, nearly unbiased, sparse and accurate variable selection methods to overcome this problem. This paper compares four regularized and one functional regression methods: Elastic Net, Multi-Step Adaptive Elastic Net, Minimax Concave Penalty, iterative Sure Independence Screening, and Functional Data Analysis for wavelength variable selection. Thereafter, the predictive performance of these regularized sparse models is enhanced using the stepwise regression. This comparative study of regression methods using a high-dimensional and highly correlated grapevine hyperspectral dataset revealed that the performance of Elastic Net for variable selection yields the best predictive ability. 展开更多
关键词 HIGH-dimensional data multi-STEP Adaptive Elastic Net MINIMAX CONCAVE Penalty Sure Independence Screening Functional data Analysis
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Research of a New Multi-dimensional Dataset Search Framework on Unstructured P2P
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作者 DENG Hui-min ZENG Bi-qing XIA Xu 《通讯和计算机(中英文版)》 2007年第1期1-7,共7页
关键词 复合型数据 数据挖掘 P2P系统 数据询问
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Model-Free Ultra-High-Dimensional Feature Screening for Multi-Classified Response Data Based on Weighted Jensen-Shannon Divergence
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作者 Qingqing Jiang Guangming Deng 《Open Journal of Statistics》 2023年第6期822-849,共28页
In ultra-high-dimensional data, it is common for the response variable to be multi-classified. Therefore, this paper proposes a model-free screening method for variables whose response variable is multi-classified fro... In ultra-high-dimensional data, it is common for the response variable to be multi-classified. Therefore, this paper proposes a model-free screening method for variables whose response variable is multi-classified from the point of view of introducing Jensen-Shannon divergence to measure the importance of covariates. The idea of the method is to calculate the Jensen-Shannon divergence between the conditional probability distribution of the covariates on a given response variable and the unconditional probability distribution of the covariates, and then use the probabilities of the response variables as weights to calculate the weighted Jensen-Shannon divergence, where a larger weighted Jensen-Shannon divergence means that the covariates are more important. Additionally, we also investigated an adapted version of the method, which is to measure the relationship between the covariates and the response variable using the weighted Jensen-Shannon divergence adjusted by the logarithmic factor of the number of categories when the number of categories in each covariate varies. Then, through both theoretical and simulation experiments, it was demonstrated that the proposed methods have sure screening and ranking consistency properties. Finally, the results from simulation and real-dataset experiments show that in feature screening, the proposed methods investigated are robust in performance and faster in computational speed compared with an existing method. 展开更多
关键词 Ultra-High-dimensional multi-Classified Weighted Jensen-Shannon Divergence MODEL-FREE Feature Screening
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Global aerodynamic design optimization based on data dimensionality reduction 被引量:14
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作者 Yasong QIU Junqiang BAI +1 位作者 Nan LIU Chen WANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2018年第4期643-659,共17页
In aerodynamic optimization, global optimization methods such as genetic algorithms are preferred in many cases because of their advantage on reaching global optimum. However,for complex problems in which large number... In aerodynamic optimization, global optimization methods such as genetic algorithms are preferred in many cases because of their advantage on reaching global optimum. However,for complex problems in which large number of design variables are needed, the computational cost becomes prohibitive, and thus original global optimization strategies are required. To address this need, data dimensionality reduction method is combined with global optimization methods, thus forming a new global optimization system, aiming to improve the efficiency of conventional global optimization. The new optimization system involves applying Proper Orthogonal Decomposition(POD) in dimensionality reduction of design space while maintaining the generality of original design space. Besides, an acceleration approach for samples calculation in surrogate modeling is applied to reduce the computational time while providing sufficient accuracy. The optimizations of a transonic airfoil RAE2822 and the transonic wing ONERA M6 are performed to demonstrate the effectiveness of the proposed new optimization system. In both cases, we manage to reduce the number of design variables from 20 to 10 and from 42 to 20 respectively. The new design optimization system converges faster and it takes 1/3 of the total time of traditional optimization to converge to a better design, thus significantly reducing the overall optimization time and improving the efficiency of conventional global design optimization method. 展开更多
关键词 Aerodynamic shape design optimization data dimensionality reduction Genetic algorithm Kriging surrogate model Proper orthogonal decomposition
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CABOSFV algorithm for high dimensional sparse data clustering 被引量:7
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作者 Sen Wu Xuedong Gao Management School, University of Science and Technology Beijing, Beijing 100083, China 《Journal of University of Science and Technology Beijing》 CSCD 2004年第3期283-288,共6页
An algorithm, Clustering Algorithm Based On Sparse Feature Vector (CABOSFV),was proposed for the high dimensional clustering of binary sparse data. This algorithm compressesthe data effectively by using a tool 'Sp... An algorithm, Clustering Algorithm Based On Sparse Feature Vector (CABOSFV),was proposed for the high dimensional clustering of binary sparse data. This algorithm compressesthe data effectively by using a tool 'Sparse Feature Vector', thus reduces the data scaleenormously, and can get the clustering result with only one data scan. Both theoretical analysis andempirical tests showed that CABOSFV is of low computational complexity. The algorithm findsclusters in high dimensional large datasets efficiently and handles noise effectively. 展开更多
关键词 CLUSTERING data mining SPARSE high dimensionality
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Similarity measurement method of high-dimensional data based on normalized net lattice subspace 被引量:4
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作者 李文法 Wang Gongming +1 位作者 Li Ke Huang Su 《High Technology Letters》 EI CAS 2017年第2期179-184,共6页
The performance of conventional similarity measurement methods is affected seriously by the curse of dimensionality of high-dimensional data.The reason is that data difference between sparse and noisy dimensionalities... The performance of conventional similarity measurement methods is affected seriously by the curse of dimensionality of high-dimensional data.The reason is that data difference between sparse and noisy dimensionalities occupies a large proportion of the similarity,leading to the dissimilarities between any results.A similarity measurement method of high-dimensional data based on normalized net lattice subspace is proposed.The data range of each dimension is divided into several intervals,and the components in different dimensions are mapped onto the corresponding interval.Only the component in the same or adjacent interval is used to calculate the similarity.To validate this method,three data types are used,and seven common similarity measurement methods are compared.The experimental result indicates that the relative difference of the method is increasing with the dimensionality and is approximately two or three orders of magnitude higher than the conventional method.In addition,the similarity range of this method in different dimensions is [0,1],which is fit for similarity analysis after dimensionality reduction. 展开更多
关键词 high-dimensional data the curse of dimensionality SIMILARITY NORMALIZATION SUBSPACE NPsim
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Nonlinear Dimensionality Reduction and Data Visualization:A Review 被引量:4
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作者 Hujun Yin 《International Journal of Automation and computing》 EI 2007年第3期294-303,共10页
Dimensionality reduction and data visualization are useful and important processes in pattern recognition. Many techniques have been developed in the recent years. The self-organizing map (SOM) can be an efficient m... Dimensionality reduction and data visualization are useful and important processes in pattern recognition. Many techniques have been developed in the recent years. The self-organizing map (SOM) can be an efficient method for this purpose. This paper reviews recent advances in this area and related approaches such as multidimensional scaling (MDS), nonlinear PC A, principal manifolds, as well as the connections of the SOM and its recent variant, the visualization induced SOM (ViSOM), with these approaches. The SOM is shown to produce a quantized, qualitative scaling and while the ViSOM a quantitative or metric scaling and approximates principal curve/surface. The SOM can also be regarded as a generalized MDS to relate two metric spaces by forming a topological mapping between them. The relationships among various recently proposed techniques such as ViSOM, Isomap, LLE, and eigenmap are discussed and compared. 展开更多
关键词 dimensionality reduction nonlinear data projection multidimensional scaling self-organizing maps nonlinear PCA principal manifold
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Augmented Industrial Data-Driven Modeling Under the Curse of Dimensionality 被引量:5
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作者 Xiaoyu Jiang Xiangyin Kong Zhiqiang Ge 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第6期1445-1461,共17页
The curse of dimensionality refers to the problem o increased sparsity and computational complexity when dealing with high-dimensional data.In recent years,the types and vari ables of industrial data have increased si... The curse of dimensionality refers to the problem o increased sparsity and computational complexity when dealing with high-dimensional data.In recent years,the types and vari ables of industrial data have increased significantly,making data driven models more challenging to develop.To address this prob lem,data augmentation technology has been introduced as an effective tool to solve the sparsity problem of high-dimensiona industrial data.This paper systematically explores and discusses the necessity,feasibility,and effectiveness of augmented indus trial data-driven modeling in the context of the curse of dimen sionality and virtual big data.Then,the process of data augmen tation modeling is analyzed,and the concept of data boosting augmentation is proposed.The data boosting augmentation involves designing the reliability weight and actual-virtual weigh functions,and developing a double weighted partial least squares model to optimize the three stages of data generation,data fusion and modeling.This approach significantly improves the inter pretability,effectiveness,and practicality of data augmentation in the industrial modeling.Finally,the proposed method is verified using practical examples of fault diagnosis systems and virtua measurement systems in the industry.The results demonstrate the effectiveness of the proposed approach in improving the accu racy and robustness of data-driven models,making them more suitable for real-world industrial applications. 展开更多
关键词 Index Terms—Curse of dimensionality data augmentation data-driven modeling industrial processes machine learning
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Similarity measure design for high dimensional data 被引量:3
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作者 LEE Sang-hyuk YAN Sun +1 位作者 JEONG Yoon-su SHIN Seung-soo 《Journal of Central South University》 SCIE EI CAS 2014年第9期3534-3540,共7页
Information analysis of high dimensional data was carried out through similarity measure application. High dimensional data were considered as the a typical structure. Additionally, overlapped and non-overlapped data ... Information analysis of high dimensional data was carried out through similarity measure application. High dimensional data were considered as the a typical structure. Additionally, overlapped and non-overlapped data were introduced, and similarity measure analysis was also illustrated and compared with conventional similarity measure. As a result, overlapped data comparison was possible to present similarity with conventional similarity measure. Non-overlapped data similarity analysis provided the clue to solve the similarity of high dimensional data. Considering high dimensional data analysis was designed with consideration of neighborhoods information. Conservative and strict solutions were proposed. Proposed similarity measure was applied to express financial fraud among multi dimensional datasets. In illustrative example, financial fraud similarity with respect to age, gender, qualification and job was presented. And with the proposed similarity measure, high dimensional personal data were calculated to evaluate how similar to the financial fraud. Calculation results show that the actual fraud has rather high similarity measure compared to the average, from minimal 0.0609 to maximal 0.1667. 展开更多
关键词 high dimensional data similarity measure DIFFERENCE neighborhood information financial fraud
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Seismic data reconstruction based on low dimensional manifold model 被引量:1
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作者 Nan-Ying Lan Fan-Chang Zhang Xing-Yao Yin 《Petroleum Science》 SCIE CAS CSCD 2022年第2期518-533,共16页
Seismic data reconstruction is an essential and yet fundamental step in seismic data processing workflow,which is of profound significance to improve migration imaging quality,multiple suppression effect,and seismic i... Seismic data reconstruction is an essential and yet fundamental step in seismic data processing workflow,which is of profound significance to improve migration imaging quality,multiple suppression effect,and seismic inversion accuracy.Regularization methods play a central role in solving the underdetermined inverse problem of seismic data reconstruction.In this paper,a novel regularization approach is proposed,the low dimensional manifold model(LDMM),for reconstructing the missing seismic data.Our work relies on the fact that seismic patches always occupy a low dimensional manifold.Specifically,we exploit the dimension of the seismic patches manifold as a regularization term in the reconstruction problem,and reconstruct the missing seismic data by enforcing low dimensionality on this manifold.The crucial procedure of the proposed method is to solve the dimension of the patches manifold.Toward this,we adopt an efficient dimensionality calculation method based on low-rank approximation,which provides a reliable safeguard to enforce the constraints in the reconstruction process.Numerical experiments performed on synthetic and field seismic data demonstrate that,compared with the curvelet-based sparsity-promoting L1-norm minimization method and the multichannel singular spectrum analysis method,the proposed method obtains state-of-the-art reconstruction results. 展开更多
关键词 Seismic data reconstruction Low dimensional manifold model REGULARIZATION Low-rank approximation
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General multidimensional cloud model and its application on spatial clustering in Zhanjiang, Guangdong 被引量:3
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作者 DENG Yu LIU Shenghe +2 位作者 ZHANG Wenting WANG Li WANG Jianghao 《Journal of Geographical Sciences》 SCIE CSCD 2010年第5期787-798,共12页
Traditional spatial clustering methods have the disadvantage of "hardware division", and can not describe the physical characteristics of spatial entity effectively. In view of the above, this paper sets forth a gen... Traditional spatial clustering methods have the disadvantage of "hardware division", and can not describe the physical characteristics of spatial entity effectively. In view of the above, this paper sets forth a general multi-dimensional cloud model, which describes the characteristics of spatial objects more reasonably according to the idea of non-homogeneous and non-symmetry. Based on infrastructures' classification and demarcation in Zhanjiang, a detailed interpretation of clustering results is made from the spatial distribution of membership degree of clustering, the comparative study of Fuzzy C-means and a coupled analysis of residential land prices. General multi-dimensional cloud model reflects the integrated char- acteristics of spatial objects better, reveals the spatial distribution of potential information, and realizes spatial division more accurately in complex circumstances. However, due to the complexity of spatial interactions between geographical entities, the generation of cloud model is a specific and challenging task. 展开更多
关键词 multi-dimensional cloud spatial clustering data mining membership degree Zhanjiang
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