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基于线粒体DNA Cyt b、12S rRNA和D-loop序列的铜鱼养殖群体遗传多样性分析
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作者 吴斌 贺刚 +3 位作者 陶志英 邓勇辉 郭怿宁 袁嘉欣 《渔业研究》 2026年第2期181-189,共9页
【目的】本研究分别利用线粒体DNA Cyt b、12S rRNA和D-loop序列对铜鱼(Coreius heterodon)养殖群体进行遗传多样性分析,初步了解其遗传多样性。【方法】采用已报道的特异性引物对线粒体DNA Cyt b、12S rRNA和D-loop序列进行聚合酶链式... 【目的】本研究分别利用线粒体DNA Cyt b、12S rRNA和D-loop序列对铜鱼(Coreius heterodon)养殖群体进行遗传多样性分析,初步了解其遗传多样性。【方法】采用已报道的特异性引物对线粒体DNA Cyt b、12S rRNA和D-loop序列进行聚合酶链式反应(PCR)扩增,并采用双脱氧测序法(Sanger)对扩增产物进行测序。遗传多样性参数由DNASP 6.12软件计算;采用MEGA 11.0软件分析DNA序列的碱基组成和变异位点;利用Kimura双参数模型计算单倍型间的遗传距离,采用邻接法(NJ)和最大似然法(ML)构建D-loop全序列单倍型系统进化树。【结果】用于分析的线粒体DNA Cyt b、12S rRNA和D-loop序列长度分别为1110~1147、425~445和972~1023 bp,平均长度分别为1122.77、430.00和1000.47 bp,中位数长度分别为1122、429和1001 bp。在线粒体DNA Cyt b、12S rRNA和D-loop序列中,分别检测出8、1和14个变异位点,以及22、19和30种单倍型,单倍型间遗传距离分别为0~0.004、0~0.005和0~0.007。基于线粒体DNA Cyt b、12S rRNA和D-loop序列的平均单倍型多样性(Hd)分别为0.547±0.0105、0.186±0.0078和0.885±0.0013;平均核苷酸多样性(Pi)分别为0.00076、0.00044和0.00258;平均核苷酸差异数(k)为0.830、0.186和2.432。同时,歧点分布分析图谱呈现单峰型,在中性检验中Tajima’s D(D=-1.040,P>0.01)为负值,但统计结果为不显著(P>0.01)。【结论】铜鱼养殖群体遗传多样性相对较低,且单倍型间存在广泛的基因交流,但铜鱼养殖群体的种群数量下降。因此,建立起遗传多样性丰富的铜鱼人工繁殖的基础亲鱼群体,解决铜鱼亲本培育问题,持续壮大铜鱼养殖群体规模是首要任务。 展开更多
关键词 铜鱼 Cyt b 12S rRNA D-loop序列 遗传多样性
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Dynamic Modeling of a Novel Multi-Loop Multi-Body Mechanism of Face-Shovel Excavator
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作者 Jisong Ding Huafeng Ding Wenjian Yang 《Chinese Journal of Mechanical Engineering》 2025年第1期323-339,共17页
Currently,research in multi-body dynamics predominantly focuses on symmetric parallel mechanisms with multiple branches.However,for the working mechanism(WM)of a face-shovel hydraulic excavator,an asymmetric mechanism... Currently,research in multi-body dynamics predominantly focuses on symmetric parallel mechanisms with multiple branches.However,for the working mechanism(WM)of a face-shovel hydraulic excavator,an asymmetric mechanism with multiple closed loops,there is a significant lack of research on dynamic models that account for the mass and inertia of all its moving components.The main focus of this study is to research a dynamic model of multi-closed-loop multi-body planar mechanism considering all moving components.This paper introduces a novel WM for a face-shovel excavator,featuring 4 loops and 12 links.By loop decomposition,the kinematic equations of the 11 primary moving components of the WM,including position,velocity,angular velocity,acceleration,and angular acceleration,are accurately formulated.For comparative analysis,a simplified dynamic model of WM was established,considering only the boom,stick,and bucket.The complete dynamic models based on the virtual work principle were also established.The correctness of both the simplified and complete dynamic models was verified through numerical simulations in Adams software.A comparison of simplified and complete dynamic simulation results shows that the new complete dynamic model has the advantage of accuracy.This research proposes a kinematic and dynamic modeling method with reference significance for the kinematic and dynamic analysis of planar complex multi-loop mechanisms,laying a foundation for performance analysis and the design of excavator WMs. 展开更多
关键词 Hydraulic face-shovel excavator DYNAMIC Kinematic Planer multi rigid body mechanism Virtual work
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Chemical-looping methane hydrogen production performance of Cu,La,Ce modified Fe_(2)O_(3)/Al_(2)O_(3)oxygen carrier
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作者 YANG Liangnuo LI Yilong +6 位作者 ZHOU Zheng DENG Chunhuan MA Hao DING Zisheng LI Guoliang LI Ming GU Zhenhua 《燃料化学学报(中英文)》 北大核心 2026年第4期82-95,共14页
Chemical looping methane steam reforming(CL-MSR)has garnered significant attention owing to its ability to sequentially produce syngas with high selectivity and high-purity hydrogen through redox cycling.To overcome t... Chemical looping methane steam reforming(CL-MSR)has garnered significant attention owing to its ability to sequentially produce syngas with high selectivity and high-purity hydrogen through redox cycling.To overcome the limitations of single ironbased oxygen carriers,including poor cycling stability,low reactivity and susceptibility to sintering,this study employed a dipcoating method to modify Fe_(2)O_(3)/Al_(2)O_(3)oxygen carriers by incorporating three distinct metal additives:Cu,La and Ce.The composite oxygen carriers were systematically characterized and evaluated under redox conditions to investigate the structure-activity relationships between the physicochemical properties,reactivity,and hydrogen production performance.Results revealed that the spinel-phase CuFe_(2)O_(4)exhibited higher reactivity than the perovskite-phase LaFeO_(3)and CeO_(2),promoting the deeper reduction of Fe_(2)O_(3).Fe58Cu2Al exhibited an oxygen storage capacity as high as 6.5 mmol/g.During the CH4 reaction stage,Fe58Cu2Al achieved the highest oxygen loss of 12.1 g/100 g oxygen carrier,accompanied by a syngas yield of 5.15 mmol/g-1.33 times and 1.59 times greater than that of Fe60Al.In the hydrogen production stage,the 2%Cu-modified oxygen carrier demonstrated optimal performance,yielding 5.13 mmol/g of hydrogen,which was 1.51 times that of the pristine sample.Even after ten cycles,the H_(2)yield remained at 3.61 mmol/g,surpassing the single-cycle output of the pristine sample and the H2 purity consistently exceeded 98%. 展开更多
关键词 chemical looping iron-based oxygen carrier metal promoter hydrogen purity
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An Improved Variant of Multi-Population Cooperative Constrained Multi-Objective Optimization(MCCMO)for Multi-Objective Optimization Problem
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作者 Muhammad Waqar Khan Adnan Ahmed Siddiqui Syed Sajjad Hussain Rizvi 《Computers, Materials & Continua》 2026年第2期1874-1888,共15页
The multi-objective optimization problems,especially in constrained environments such as power distribution planning,demand robust strategies for discovering effective solutions.This work presents the improved variant... The multi-objective optimization problems,especially in constrained environments such as power distribution planning,demand robust strategies for discovering effective solutions.This work presents the improved variant of the Multi-population Cooperative Constrained Multi-Objective Optimization(MCCMO)Algorithm,termed Adaptive Diversity Preservation(ADP).This enhancement is primarily focused on the improvement of constraint handling strategies,local search integration,hybrid selection approaches,and adaptive parameter control.Theimproved variant was experimented on with the RWMOP50 power distribution systemplanning benchmark.As per the findings,the improved variant outperformed the original MCCMO across the eleven performance metrics,particularly in terms of convergence speed,constraint handling efficiency,and solution diversity.The results also establish that MCCMOADP consistently delivers substantial performance gains over the baseline MCCMO,demonstrating its effectiveness across performancemetrics.The new variant also excels atmaintaining the balanced trade-off between exploration and exploitation throughout the search process,making it especially suitable for complex optimization problems in multiconstrained power systems.These enhancements make MCCMO-ADP a valuable and promising candidate for handling problems such as renewable energy scheduling,logistics planning,and power system optimization.Future work will benchmark the MCCMO-ADP against widely recognized algorithms such as NSGA-Ⅱ,NSGA-Ⅲ,and MOEA/D and will also extend its validation to large-scale real-world optimization domains to further consolidate its generalizability. 展开更多
关键词 MCCMO algorithms adaptive diversity preservation RWMOP50 power distribution system multi-modal multi objective optimization evolutionary algorithm multi objective problem
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Investigation on Aerodynamic Interaction of Tandem Tilt⁃Wing and Multi⁃rotor in Transition Condition
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作者 DENG Jinghui YUAN Mingchuan +2 位作者 HUANG Shuilin SUN Huixun ZHANG Zihan 《Transactions of Nanjing University of Aeronautics and Astronautics》 2026年第1期1-14,共14页
The complex aerodynamic interaction between tandem tilt-wing and multi-rotor directly affects the wing surface flow and rotor thrust,making it a critical factor during the tilt transition process of this configuration... The complex aerodynamic interaction between tandem tilt-wing and multi-rotor directly affects the wing surface flow and rotor thrust,making it a critical factor during the tilt transition process of this configuration of rotorcraft.The aerodynamic interaction of tandem tilt-wing and multi-rotor is investigated based on the CFD method.The aerodynamic effect of multi tilt-rotor is simulated as virtual disk modeling by adding source terms to the Navier-Stokes equations,effectively reducing the calculation time while maintaining the accuracy of aerodynamic interaction calculations.Aerodynamic forces and flow field characteristics of the tandem tilt-wing and multi-rotor under different tilt angles are compared between cases with and without aerodynamic interaction.Furthermore,the differences in aerodynamic forces between dynamic tilt transition and fixed-angle conditions were compared.The results show that the aerodynamic interaction of multi-rotor obviously increases the lift of front tilt-wing at different tilt angles,the wing lift under interaction is increased by more than 40%compared with isolated wing at tilt angle of 15°for the computation in this paper,which is related to the increase of wing flow velocity and the suppression of flow separation caused by multi-rotor;the wing blocking effect will increase rotor thrust,especially near the tilt angles of 30°and 45°;the increases of rear wing lift and rear rotor thrust under aerodynamic interaction are not significant because of suppression by the front wing’s downwash;the unsteady effects during dynamic tilting have a relatively minor impact on aerodynamic interaction,with the aerodynamic forces on the rotors and wings during the dynamic tilting process showing little difference from those under corresponding fixed tilt angles. 展开更多
关键词 aerodynamic interaction TANDEM tilt-wing multi tilt-rotors transition condition
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Synchronization Stability Analysis of Multi-VSC Grid-connected System via Multi-scale Method
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作者 Meng Huang Yangjian Ling +3 位作者 Han Yan Xikun Fu Xiaoming Zha Herbert Ho-Ching Iu 《CSEE Journal of Power and Energy Systems》 2026年第1期282-293,共12页
In a multiple voltage source converter(VSC)system,the nonlinear characteristics of phase-locked loops(PLLs)and their interactions have a significant influence on the synchronization stability of converters.In this pap... In a multiple voltage source converter(VSC)system,the nonlinear characteristics of phase-locked loops(PLLs)and their interactions have a significant influence on the synchronization stability of converters.In this paper,these influences are investigated from the perspective of the time domain.First,a novel time-domain model of the multi-VSC system is obtained by using a multi-scale method.On this basis,a stability criterion is proposed to assess the synchronization stability of the system.Then,the accuracy of the time-domain model and its stability criterion in various conditions are discussed.Moreover,the negative impact of the interaction on the system is quantified.Finally,the above theoretical analysis is also verified in the controller hardware-in-the-loop(CHIL)experiments. 展开更多
关键词 multi-scale method multi-VSC phase-locked loops synchronization stability time-domain model
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Tamed loops:a way to obtain finite loop results without UV divergences
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作者 Lian-Bao Jia 《Communications in Theoretical Physics》 2026年第1期71-79,共9页
For loops with UV divergences,assuming that the physical contributions of loops from UV regions are insignificant,a UV-free scheme method described by an equation is introduced to derive loop results without UV diverg... For loops with UV divergences,assuming that the physical contributions of loops from UV regions are insignificant,a UV-free scheme method described by an equation is introduced to derive loop results without UV divergences in the calculations,i.e.,a route of the analytic continuation T_(F)→T_(P)besides the traditional route∞-∞in the mathematical structure.This scheme provides a new perspective to an open question of the hierarchy problem of Higgs mass,i.e.,an alternative interpretation without fine-tuning within the standard model. 展开更多
关键词 UV divergence loop calculation UV-free scheme Higgs mass hierarchy problem
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DFCOA:Distributed Formation Control and Obstacle Avoidance for Multi-UGV Systems
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作者 Md.Faishal Rahaman Xueyuan Li +3 位作者 Muhammad Amjad Ibrahim Gasimove Md.Shariful Islam S.M.Abul Bashar 《Computer Modeling in Engineering & Sciences》 2026年第2期922-954,共33页
Researchers are increasingly focused on enabling groups of multiple unmanned vehicles to operate cohesively in complex,real-world environments,where coordinated formation control and obstacle avoidance are essential f... Researchers are increasingly focused on enabling groups of multiple unmanned vehicles to operate cohesively in complex,real-world environments,where coordinated formation control and obstacle avoidance are essential for executing sophisticated collective tasks.This paper presents a Distributed Formation Control and Obstacle Avoidance(DFCOA)framework for multi-unmanned ground vehicles(UGV).DFCOA integrates a virtual leader structure for global guidance,an improved A^(*)path planning algorithm with an advanced cost function for efficient path planning,and a repulsive-force-based improved vector field histogram star(VFH^(*))technique for collision avoidance.The virtual leader generates a reference trajectory while enabling distributed execution;the improved A^(*)algorithm reduces planning time and number of nodes to determine the shortest path from the starting position to the goal;and the improved VFH^(*)uses 2D LiDAR data with inter-agent repulsive force to simultaneously avoid collision with obstacles and maintain safe inter-vehicle distances.The formation stability of the proposed DFCOA reaches 95.8%and 94.6%in two scenarios,with root mean square(RMS)centroid errors of 0.9516 and 1.0008 m,respectively.Velocity tracking is precise(velocity centroid error RMS of 0.2699 and 0.1700 m/s),and linear velocities closely match the desired 0.3 m/s.Safety metrics showed average collision risks of 0.7773 and 0.5143,with minimum inter-vehicle distances of 0.4702 and 0.8763 m,confirming collision-free navigation of four UGVs.DFCOA outperforms conventional methods in formation stability,path efficiency,and scalability,proving its suitability for decentralized multi-UGV applications. 展开更多
关键词 Formation control obstacle avoidance virtual leader path planning multi UGV collaboration
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Face-Pedestrian Joint Feature Modeling with Cross-Category Dynamic Matching for Occlusion-Robust Multi-Object Tracking
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作者 Qin Hu Hongshan Kong 《Computers, Materials & Continua》 2026年第1期870-900,共31页
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba... To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions. 展开更多
关键词 Cross-category dynamic binding joint feature modeling face-pedestrian association multi object tracking occlusion robustness
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Bioinspired Design of Extraordinary Wear‐Resistant Graphene/CoCrNi Multi‐Principal Element Alloy Composites
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作者 Wen‐Ting Ye Shuo Li +8 位作者 Yu‐Sen Li Qing Zhou Long‐Hui Zhu Biao Chen Yi‐Xuan He Hai‐Feng Wang Benyebka Bou‐Saïd Evgeny Trofimov Wei‐Min Liu 《cMat》 2026年第1期24-41,共18页
The pursuit of simultaneously high wear resistance and excellent lubrication in multi‐principal element alloy(MPEA)composites is often hindered by a fundamental trade‐off,which is exacerbated by the agglomeration of... The pursuit of simultaneously high wear resistance and excellent lubrication in multi‐principal element alloy(MPEA)composites is often hindered by a fundamental trade‐off,which is exacerbated by the agglomeration of high‐content graphene reinforcements.This compromise becomes particularly severe in composites with high‐content graphene reinforcements,whose agglomeration leads to embrittlement and lubrication failure.Here,a flake powder-metallurgy strategy is developed to construct a self‐assembled lamellar structure in graphene/CoCrNi MPEA composites(Gr/MPEA_(AL)).This approach enables the uniform dispersion of a high graphene content(3.0 wt%),which is unattainable by conventional methods.The resulting composite exhibits a rare dual enhancement in performance:an order‐of‐magnitude improvement in wear resistance coupled with a low coefficient of friction.Intriguingly,the tribological behavior shows significant anisotropy,with optimal performance observed when sliding perpendicular to the lamellae.Through a multi‐scale methodology combining molecular dynamics simulations,finite element analysis,and systematic experiments,it is revealed that this exceptional performance stems from the synergy of high‐density deformation nanotwins,efficient strain delocalization,and abundant graphene‐derived lubricating sites.This work establishes a general paradigm for designing composite architectures that reconcile traditionally incompatible properties,offering broad implications for developing next‐generation structural materials with integrated mechanical robustness and surface functionality for safety‐critical applications. 展开更多
关键词 GRAPHENE wear resistance flake powder metallurgy CoCrNi multi principal element alloy lubrication bioinspired design strain delocalization lamellar structure
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Integrated multi-omics dissects receptor-mediated phytomelatonin signaling
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作者 Ying Liu Shirui Jing +5 位作者 Yuhao Zheng Qiuyu He Chengcheng Shen Junxin Guo Yangdong Guo Na Zhang 《Horticultural Plant Journal》 2026年第2期485-488,共4页
Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging ... Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging complex networks and interacting with other phytohormones(Liu et al.,2022;Khan et al.,2023).Although phytomelatonin receptors(PMTRs)have been identified in many plants(Wei et al.,2018;Wang et al.,2022;Liu et al.,2025),the downstream signaling mechanisms,particularly receptor-mediated protein modifications and transcriptional regulation,remain poorly characterized. 展开更多
关键词 phytomelatonin receptors pmtrs transcriptional regulation signaling moleculeengaging complex networks integrated multi omics PHYTOHORMONES protein modifications plant hormoneplays phytomelatonin signaling
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AI-driven integration of multi-omics and multimodal data for precision medicine
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作者 Heng-Rui Liu 《Medical Data Mining》 2026年第1期1-2,共2页
High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging ... High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1). 展开更多
关键词 high throughput transcriptomics multi omics single cell multimodal learning frameworks foundation models omics data modalitiesemerging ai driven precision medicine
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Seeing amyotrophic lateral sclerosis in a multi-omic perspective
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作者 Natalie Dikwella Paul Lingor Laura Tzeplaeff 《Neural Regeneration Research》 2026年第8期3567-3568,共2页
Amyotrophic lateral sclerosis(ALS)is a rapidly progressing neurodegenerative disease,leading to muscle weakness,paralysis and ultimately death due to respiratory failure.Currently licensed drugs have only very limited... Amyotrophic lateral sclerosis(ALS)is a rapidly progressing neurodegenerative disease,leading to muscle weakness,paralysis and ultimately death due to respiratory failure.Currently licensed drugs have only very limited effects on slowing down disease progression or biomarkers.Despite numerous successful preclinical analyses,most new drugs fail when translated to clinical trials(Petrov et al.,2017).This is believed to be,in part,due to the multilayer heterogeneity of ALS(e.g.,clinical,genetic,and molecular;Tzeplaeff et al.,2024).Studies integrating multi-omic data are still limited,making it difficult to fully understand the biological complexity that characterizes the disease. 展开更多
关键词 amyotrophic lateral sclerosis als clinical trials petrov multi omic PARALYSIS muscle weakness neurodegenerative diseaseleading amyotrophic lateral sclerosis neurodegenerative disease
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Intelligent integration and advancement of multi-organ-on-a-chip
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作者 Chen-Xi Song Lu Huang 《Biomedical Engineering Communications》 2026年第1期1-3,共3页
Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technol... Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy. 展开更多
关键词 investigating complex disease mechanisms emulate complex interactions multiple human organs vitro sensor integration intelligent integration predictive accuracy physiological coupling multi organ chip microfluidic systemsthis
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Multi-objective ANN-driven genetic algorithm optimization of energy efficiency measures in an NZEB multi-family house building in Greece
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《建筑节能(中英文)》 2026年第2期62-62,共1页
The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measu... The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measures in a multi-family house building in Greece.The energy efficiency measures include different heating/cooling systems(such as low-temperature and high-temperature heat pumps,natural gas boilers,split units),building envelope components for floor,walls,roof and windows of variable heat transfer coefficients,the installation of solar thermal collectors and PVs.The calculations of the building loads and investment and operating and maintenance costs of the measures are based on the methodology defined in Directive 2010/31/EU,while economic assumptions are based on EN 15459-1 standard.Typically,multi-objective optimization of energy efficiency measures often requires the simulation of very large numbers of cases involving numerous possible combinations,resulting in intense computational load.The results of the study indicate that ANN-driven GA methods can be used as an alternative,valuable tool for reliably predicting the optimal measures which minimize primary energy consumption and life cycle cost of the building with greatly reduced computational requirements.Through GA methods,the computational time needed for obtaining the optimal solutions is reduced by 96.4%-96.8%. 展开更多
关键词 energy efficiency measures gas boilerssplit units building envelope components energy efficiency economic performance artificial neural network ann driven multi objective optimization economic performance optimization ANN driven GA methods
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Intelligent Reconfigurable Skyrmion-Based Multi-Port Logic Device for In-Memory Computing
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作者 Fuhao Zou Ziyuan Liu +3 位作者 Zijing Zhao Muhammad Humayun Chundong Wang Xiaolei Wang 《Chinese Physics Letters》 2026年第3期331-345,共15页
New electronic devices based on the physical properties of electrically driven skyrmions are promising for logic computing and nonvolatile memory applications.However,achieving efficient and practical compute-storage ... New electronic devices based on the physical properties of electrically driven skyrmions are promising for logic computing and nonvolatile memory applications.However,achieving efficient and practical compute-storage integration remains challenging owing to the structural complexity,limited functionality,and low flexibility observed in most skyrmion-based devices.In this study,we designed a novel device architecture that integrates seven basic logic gates into a unified physical structure.Their operation can be enabled by physical mechanisms,such as spin-orbit torque,spin-transfer torque,skyrmion-edge repulsions,and skyrmion-skyrmion interactions.Furthermore,by incorporating voltage-controlled magnetic anisotropy,the device achieved multi-input capability and reconfigurability functionality.Ultralow power consumption(<1 fJ/bit per logic function)and extremely high logic density were achieved.Significantly,the compatibility of this nanotrack design with existing skyrmion racetrack memory paves the way for advanced in-memory computing in spintronic architectures. 展开更多
关键词 voltage controlled magnetic anisotropy intelligent reconfigurable skyrmion based multi port logic device memory computing logic computing device architecture spin transfer torque spin orbit torque integrates seven basic logic gates
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依赖于c-Myc的R-loops结构对胶质瘤细胞增殖、侵袭和迁移的调控作用
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作者 林家汉 陈彩燕 +2 位作者 陈申波 叶富跃 杨堃 《中华神经外科疾病研究杂志》 2026年第2期16-22,共7页
目的探讨转录因子c-Myc的R-loops结构及其对胶质瘤细胞恶性生物学行为的调控作用。方法采用DNA-RNA免疫沉淀PCR(DNA-RNA immunoprecipitation PCR,DRIP-PCR)法检测胶质瘤细胞(U251和U87-MG)中c-Myc的R-loops结构。分别将空载质粒、c-My... 目的探讨转录因子c-Myc的R-loops结构及其对胶质瘤细胞恶性生物学行为的调控作用。方法采用DNA-RNA免疫沉淀PCR(DNA-RNA immunoprecipitation PCR,DRIP-PCR)法检测胶质瘤细胞(U251和U87-MG)中c-Myc的R-loops结构。分别将空载质粒、c-Myc过表达质粒、RNASEH1过表达质粒转染至U251和U87-MG细胞,设立对照组(CTRL组)、核糖核酸内切酶H1(RNASEH1)过表达组(RNASEH1-OE组)、c-Myc过表达组(c-Myc-OE组)及共转染c-Myc与RNASEH1共转染组(c-Myc-OE+RNASEH1-OE组)。采用细胞计数试剂盒-8(CCK-8)、5-乙炔基-2'-脱氧尿苷(EdU)实验检测细胞增殖能力;通过细胞划痕实验和Transwell实验评估细胞迁移和侵袭水平;利用蛋白印迹法(Western blot)检测RNASEH1和c-Myc的蛋白表达水平。结果转录因子c-Myc在胶质瘤细胞中存在R-loops结构(P<0.05)。过表达RNASEH1可清除c-Myc依赖的R-loops结构,从而抑制胶质瘤细胞的增殖、侵袭和迁移(P<0.05)。c-Myc的过表达可提高核糖核酸内切酶H1(RNASEH1)的表达,从而挽救其R-loops结构,促进胶质瘤细胞侵袭和迁移能力的影响(P<0.05)。结论转录因子c-Myc可能通过其R-loops结构促进胶质瘤细胞的增殖、侵袭和迁移等恶性生物学行为。 展开更多
关键词 C-MYC 核糖核酸内切酶H1 R环 胶质瘤 增殖 侵袭 迁移
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SNF5协同RNA解旋酶DDX5缓解R-loop积累维持肿瘤细胞基因组稳定性
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作者 高源 谢晓娟 胡开顺 《岭南现代临床外科》 2026年第1期10-21,共12页
目的探讨染色质重塑因子SNF5在肿瘤细胞增殖和基因组稳定性维持中的作用及其分子机制。方法采用CRISPR-Cas9技术构建SNF5敲除的HeLa细胞株,通过EdU增殖实验和流式细胞术分析细胞增殖及周期变化;利用克隆形成实验评估细胞对IR、HU、CPT和... 目的探讨染色质重塑因子SNF5在肿瘤细胞增殖和基因组稳定性维持中的作用及其分子机制。方法采用CRISPR-Cas9技术构建SNF5敲除的HeLa细胞株,通过EdU增殖实验和流式细胞术分析细胞增殖及周期变化;利用克隆形成实验评估细胞对IR、HU、CPT和MMC的敏感性;DNA fiber实验检测DNA复制速率;S9.6免疫荧光分析R-loop水平;IP-MS筛选复制压力下SNF5的互作蛋白;通过Co-IP和GST pull-down实验验证SNF5与RNA解旋酶DDX5的相互作用。结果HeLa细胞中,SNF5缺失导致细胞DNA合成受阻,G1期细胞比例升高;SNF5敲除细胞的增殖能力下降,对放化疗药物的敏感性显著增加。DNA fiber实验显示SNF5敲除细胞复制速率降低,R-loop水平显著升高。蛋白互作分析证实SNF5可与DDX5结合,共同缓解复制压力下的R-loop积累。结论SNF5通过与RNA解旋酶DDX5协同作用,减少R-loop形成,维持DNA复制速率与基因组稳定性,从而促进肿瘤细胞增殖;SNF5缺失增强了肿瘤细胞对放化疗的敏感性,提示其可能是潜在的抗肿瘤治疗靶点。 展开更多
关键词 SNF5 R-loop RNA解旋酶家族 复制压力 基因组稳定性
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基于化工过程事故知识谱图-多头时间注意力图网络(CPAKG-MultiTGAT)的化工过程事故情景推演模型
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作者 郑琛 陈国华 +1 位作者 赵远飞 杨运锋 《化工进展》 北大核心 2026年第2期1243-1254,共12页
针对化工园区事故演化过程复杂多变的特征及传统推演方法时空特征融合不足的问题,本文提出了基于CPAKG-MultiTGAT的化工过程事故情景推演模型。通过解析485起化工事故案例,构建涵盖5类本体、74种情景节点的化工过程事故知识谱图(chemica... 针对化工园区事故演化过程复杂多变的特征及传统推演方法时空特征融合不足的问题,本文提出了基于CPAKG-MultiTGAT的化工过程事故情景推演模型。通过解析485起化工事故案例,构建涵盖5类本体、74种情景节点的化工过程事故知识谱图(chemical process accident knowledge graph,CPAKG),实现事故要素的时空关联建模。创新设计的多头时间注意力图网络(multi-head temporal graph attention network,MultiTGAT)融合时间戳编码与图结构特征,以CPAKG的时空拓扑为输入,动态解析节点间跨时空的耦合关系,实现事故情景演化链路预测。实验表明,在自建数据集上,模型AUC与AP值分别达0.865和0.858,较GCN、TGAT-NoTime等基准模型有显著提升,能够有效推演事故演化链路。本文研究成果为化工为事故情景推演提供了可解释的数字化工具,推动事故分析从经验驱动向“数据-知识”融合转型,对提升事故防控能力具有重要的工程应用价值。 展开更多
关键词 化工园区 化工过程事故 情景推演 知识谱图 多头时间注意力图网络
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DS-CDMA system outer loop power control and improvement for multi-service 被引量:3
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作者 Guan Mingxiang Guo Qing Li Xing 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第3期453-460,共8页
When a new user accesses the CDMA system, the load will change drastically, and therefore, the advanced outer loop power control (OLPC) technology has to be adopted to enrich the target signal interference ratio (S... When a new user accesses the CDMA system, the load will change drastically, and therefore, the advanced outer loop power control (OLPC) technology has to be adopted to enrich the target signal interference ratio (Silt) and improve the system performance. The existing problems about DS-CDMA outer loop power control for multi-service are introduced and the power control theoretical model is analyzed. System simulation is adopted on how to obtain the theoretical performance and parameter optimization of the power control algorithm. The OLPC algorithm is improved and the performance comparisons between the old algorithm and the improved algorithm are given. The results show good performance of the improved OLPC algorithm and prove the validity of the improved method for multi-service. 展开更多
关键词 DS-CDMA outer loop power control multi-SERVICE performance.
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