The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and ...The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and fluid mobility due to the influences of the northeast and northwest dual provenance systems.This study performed multiple experimental analyses on nine samples from the area to determine the petrological and petrophysical properties,as well as the PTS characteristics of reservoirs in different provenance-controlled regions.On this basis,the pore-throat size distribution(PSD)obtained from high-pressure mercury injection(HPMI)was utilized to convert the NMR movable fluid T2spectrum,allowing for quantitative characterization of the full PSD and the occurrence characteristics of movable fluids.A systematic analysis was conducted on the primary controlling factors affecting fluid mobility in the reservoir.The results indicated that the lithology in the eastern and western regions is lithic arkose.The eastern sandstones,being farther from the provenance,exhibit higher contents of feldspar and lithic fragments,along with the development of more dissolution pores.The reservoir possesses good petrophysical properties,low displacement pressure,and high pore-throat connectivity and homogeneity,indicating strong fluid mobility.In contrast,the western sandstones,being nearer to the provenance,exhibit poor grain sorting,high contents of lithic fragments,strong compaction and cementation effects,resulting in poor petrophysical properties,and strong pore-throat heterogeneity,revealing weak fluid mobility.The range of full PSD in the eastern reservoir is wider than that in the western reservoir,with relatively well-developed macropores.The macropores are the primary space for occurrence of movable fluids,and controls the fluid mobility of the reservoir.The effective porosity of movable fluids(EPMF)quantitatively represents the pore space occupied by movable fluids within the reservoir and correlates well with porosity,permeability,and PTS parameters,making it a valuable parameter for evaluating fluid mobility.Under the multi-provenance system,the eastern and western reservoirs underwent different sedimentation and diagenesis processes,resulting in differential distribution of reservoir mineral components and pore types,which in turn affects the PTS heterogeneity and reservoir quality.The composition and content of reservoir minerals are intrinsic factors influencing fluid mobility,while the microscopic PTS is the primary factor controlling it.Low clay mineral content,welldeveloped macropores,and weak pore-throat heterogeneity all contribute to the storage and seepage of reservoir fluids.展开更多
This study presents a theoretical and experimental analysis of laminar flow behavior of high-viscous non-Newtonian power-law and Bingham fluids in multiple structural bifurcation channel distributors.Theoretical model...This study presents a theoretical and experimental analysis of laminar flow behavior of high-viscous non-Newtonian power-law and Bingham fluids in multiple structural bifurcation channel distributors.Theoretical models are derived to describe velocity profiles,shear rate distribution,and pressure drop across specific channels.Modified pressure drop models are proposed based on experiments on 6 kinds of non-Newtonian fluids and 3 types of bifurcation channel distributors with different transition areas.Specifically,the deviations between the theoretical models and the experimental results are systematically analyzed,and models were modified with correction coefficients based on Reynolds number and dimensionless shape factor.The theoretical results,modified results and experimental data are compared and discussed to ensure the accuracy of the modified models,demonstrating a significant improvement in the prediction of pressure drops for high-viscous non-Newtonian fluids in certain types of bifurcation channels.Additional experiments and analyses were carried out to validate the modified models and the results suggest that the models offer a certain degree of universal applicability in bifurcation channel designs.It implies that for other types of bifurcation channel distributors,similar correction methods based on Reynolds number and shape factor may also be applicable even with different coefficients.展开更多
The wave-induced fluid flow(WIFF) occurring in the ubiquitous layered porous media(e.g.,shales)usually causes the appreciable seismic energy dissipation,which further leads to the frequency dependence of wave velocity...The wave-induced fluid flow(WIFF) occurring in the ubiquitous layered porous media(e.g.,shales)usually causes the appreciable seismic energy dissipation,which further leads to the frequency dependence of wave velocity(i.e.,dispersion) and elastic anisotropy parameters.The relevant knowledge is of great importance for geofluid discrimination and hydrocarbon exploration in the porous shale reservoirs.We derive the wave equations for a periodic layered transversely isotropy medium with a vertical axis of symmetry(VTI) concurrently with the annular cracks(PLPC medium) based on the periodic-layered model and anisotropic Biot's theory,which simultaneously incorporate the effects of microscopic squirt fluid flow,mesoscopic interlayer fluid flow and macroscopic global fluid flow.Notably,the microscopic squirt shorten fluid flow emerges between the annular-shaped cracks and stiff pores,which generates one attenuation peak.Specifically,we first establish the stress-strain relationship and pore fluid pressure in a PLPC medium,and then use them to derive the wave equations by means of the Newton's second law.The plane analysis is implemented on the wave equations to yield the analytic solutions for phase velocities and attenuation factors of four waves,namely,fast P-wave,slow P-wave,SV-wave and SH-wave,and the anisotropy parameters can be therefore computed.Simulation results show that P-wave velocity have three attenuation peaks throughout the full frequency band,which respectively correspond to the influences of interlayer flow,the squirt flow and the Biot flow.Through the results of seismic velocity dispersion and attenuation at different incident angles,we find that the WIFF mechanism also has a significant impact on the dispersion characteristics of elastic anisotropy parameters within the low-mid frequency band.Moreover,it is shown that several poroelastic parameters,such as layer thickness ratio,crack aspect ratio and crack density have notable influence on seismic dispersion and attenuation.We compare the proposed modeled velocities with that given by the existing theory to confirm its validity.Our formulas and result can provide a better understanding of wave propagation in PLPC medium by considering the unified impacts of micro-,meso-and macro-scale WIFF mechanisms,which potentially lays a theoretical basis of rock physics for seismic interpretation.展开更多
In the version of the article originally published in the volume 68,issue 12,2025 of Sci China Mater(pages 4413-4422,https://doi.org/10.1007/s40843-025-3667-7),the Chinese name of the co-first author(肖天孝)was incorr...In the version of the article originally published in the volume 68,issue 12,2025 of Sci China Mater(pages 4413-4422,https://doi.org/10.1007/s40843-025-3667-7),the Chinese name of the co-first author(肖天孝)was incorrect.The corrected Chinese name is:肖天笑.展开更多
Researchers are increasingly focused on enabling groups of multiple unmanned vehicles to operate cohesively in complex,real-world environments,where coordinated formation control and obstacle avoidance are essential f...Researchers are increasingly focused on enabling groups of multiple unmanned vehicles to operate cohesively in complex,real-world environments,where coordinated formation control and obstacle avoidance are essential for executing sophisticated collective tasks.This paper presents a Distributed Formation Control and Obstacle Avoidance(DFCOA)framework for multi-unmanned ground vehicles(UGV).DFCOA integrates a virtual leader structure for global guidance,an improved A^(*)path planning algorithm with an advanced cost function for efficient path planning,and a repulsive-force-based improved vector field histogram star(VFH^(*))technique for collision avoidance.The virtual leader generates a reference trajectory while enabling distributed execution;the improved A^(*)algorithm reduces planning time and number of nodes to determine the shortest path from the starting position to the goal;and the improved VFH^(*)uses 2D LiDAR data with inter-agent repulsive force to simultaneously avoid collision with obstacles and maintain safe inter-vehicle distances.The formation stability of the proposed DFCOA reaches 95.8%and 94.6%in two scenarios,with root mean square(RMS)centroid errors of 0.9516 and 1.0008 m,respectively.Velocity tracking is precise(velocity centroid error RMS of 0.2699 and 0.1700 m/s),and linear velocities closely match the desired 0.3 m/s.Safety metrics showed average collision risks of 0.7773 and 0.5143,with minimum inter-vehicle distances of 0.4702 and 0.8763 m,confirming collision-free navigation of four UGVs.DFCOA outperforms conventional methods in formation stability,path efficiency,and scalability,proving its suitability for decentralized multi-UGV applications.展开更多
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba...To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions.展开更多
Rhegmatogenous retinal detachment(RRD)is a serious ocular condition marked by the separation of the neuroretina from the retinal pigment epithelium(RPE).The pathogenesis of RRD involves intricate molecular and cellula...Rhegmatogenous retinal detachment(RRD)is a serious ocular condition marked by the separation of the neuroretina from the retinal pigment epithelium(RPE).The pathogenesis of RRD involves intricate molecular and cellular mechanisms,including inflammation,cell migration,and the activation of proliferative signaling pathways.One of the most challenging complications of RRD is proliferative vitreoretinopathy(PVR),which refers to the proliferation and contraction of fibrocellular membranes on the retinal surface and in the vitreous cavity.PVR is a major cause of surgical failure in RRD,as it can lead to recurrent retinal detachment and severe vision loss.However,the pathogenesis of PVR is not yet fully understood,and the treatment options are quite limited.Recent advances in analytical techniques have offered valuable insights into the molecular alterations present in the subretinal fluid(SRF)of patients with RRD.This review seeks to consolidate the current knowledge regarding the SRF profile in RRD and PVR,emphasizing potential biomarkers and therapeutic targets.展开更多
The formation of copper deposits is closely related to hydrothermal processes.Understanding the migration of copper in hydrothermal fluids aids in reconstructing mineralization processes and deciphering deposit genesi...The formation of copper deposits is closely related to hydrothermal processes.Understanding the migration of copper in hydrothermal fluids aids in reconstructing mineralization processes and deciphering deposit genesis.Copper primarily exists as Cu^(+)and Cu^(2+)in hydrothermal solutions,with redox conditions governing their interconversion.In chloride-rich geological fluids,Cu-Cl complexes are considered critical for copper transport.However,the specific types and valence transitions of Cu-Cl complexes under varying hydrothermal conditions remain poorly understood.This study employed in situ Raman spectroscopy to systematically analyze Cu+HCl and CuCl_(2)+K_(2)S_(2)O_(3)/H_(2) systems under saturated vapor pressure at 25-300℃,elucidating the effects of temperature,Cl^(-)concentration,and redox conditions on copper speciation.In the Cu^(+)HCl system,copper dissolved as monovalent Cu-Cl complexes.At high temperatures(>200℃),[CuCl_(2)]^(-)is the dominated species,whereas[CuCl_(3)]^(2-)becomes prevalent at lower temperatures and higher HCl concentrations.For the Cu^(2+)-Cl system,the dominant species transitioned from[Cu(H_(2)O)n]^(2+)(<50℃)to[CuCl_(4)]^(2-)(100℃)and further to[CuCl]^(+)and[CuCl_(2)]^(0) at 300℃.The introduction of reducing agents(K_(2)S_(2)O_(3)/H_(2))facilitated Cu^(2+)→Cu^(+)reduction,thereby stabilizing Cu^(+)-Cl complexes and inducing partial copper precipitation.The behavior of copper in chloriderich hydrothermal fluids observed in this study indicates that high-temperature oxidizing fluids facilitate Cu mobilization,while cooling and redox changes promote deposition and ore minerals formation.展开更多
As a multidisciplinary phenomenon,panel aeroelasticity in shock-dominated flow is featured by two primary interactions:Fluid-Structure Interactions(FSIs)and Shock-Boundary Layer Interactions(SBLIs).The former raises s...As a multidisciplinary phenomenon,panel aeroelasticity in shock-dominated flow is featured by two primary interactions:Fluid-Structure Interactions(FSIs)and Shock-Boundary Layer Interactions(SBLIs).The former raises structural concerns,and the latter is of aerodynamic interest.Thus,panel aeroelasticity in shock-dominated flow represents a vital topic for the development and optimization of supersonic vehicles and propulsion systems.This review systematically summarizes recent advances in the methodologies applied to capture structural and fluid dynamics,including theoretical models,numerical simulations,and wind tunnel experiments.The application of data-driven modal decomposition,an advanced technique to extract physically crucial features,on the topic is introduced.From the perspective of FSIs,the distinctive aeroelastic behaviors in shock-dominated flow,including hysteresis phenomena and nonlinear responses,are highlighted.From the perspective of SBLIs,the modifications in their spatial and temporal characteristics imposed by the aeroelastic responses are emphasized.Motivated by the interaction between the shock waves and structural response,different strategies have been proposed to implement aeroelastic suppression and shock control,which have the potential to enhance structural safety and aerodynamic performance in the next generation of high-speed flight vehicles.展开更多
When a porous rock is subjected to overall compressive loading,either increasing pore pressure or decreasing confining pressure could result in rock failure.The stress path and the applied pressure change rate may aff...When a porous rock is subjected to overall compressive loading,either increasing pore pressure or decreasing confining pressure could result in rock failure.The stress path and the applied pressure change rate may affect the initiation and propagation of fractures within brittle materials.Understanding the physical mechanisms leading to failure is crucial for underground engineering applications and geo-energy exploration and storage.We conducted triaxial compression experiments on porous Bentheim sandstone samples at different stress paths and pressure change rates.First,at a constant confining pressure of 35 MPa and pore pressure of 5 MPa,intact cylindrical samples were axially loaded up to about 85%of the peak strength.Subsequently,the axial piston position was fixed,and then either the pore pressure was increased or the confining pressure was decreased at two different rates(0.5 MPa/min or 2 MPa/min),leading to final catastrophic failure.The mechanical results revealed that samples subjected to higher rates of decreasing effective confining pressure exhibited larger stress drop rates,higher slip rates,higher total breakdown work,higher rates of acoustic emissions(AEs)before failure,and higher post-failure AE decay rates.In contrast,the applied stress path did not significantly affect rock failure characteristics.Comparison of located AE events with post-mortem microstructures of deformed samples shows a good agreement.The AE source type determined from the P-wave first-motion polarity shows that shear failure dominated the fracture process when approaching failure.Gutenberg-Richter b-values revealed a significant decrease before failure in all tests.Our results indicate that,in contrast to the stress path,the rate of effective stress change strongly affects fracturing behavior and AE rate changes.展开更多
Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging ...Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging complex networks and interacting with other phytohormones(Liu et al.,2022;Khan et al.,2023).Although phytomelatonin receptors(PMTRs)have been identified in many plants(Wei et al.,2018;Wang et al.,2022;Liu et al.,2025),the downstream signaling mechanisms,particularly receptor-mediated protein modifications and transcriptional regulation,remain poorly characterized.展开更多
The migration mechanisms of ore-forming fluids have long been a focus in the field of ore deposit studies.Calcite is ubiquitously present in various types of rocks in the lithosphere,and the underlying mechanisms of i...The migration mechanisms of ore-forming fluids have long been a focus in the field of ore deposit studies.Calcite is ubiquitously present in various types of rocks in the lithosphere,and the underlying mechanisms of its influence on fluid migration are of crucial importance.While previous studies have revealed that salinity changes can modulate fluid migration,the underlying mechanisms remain poorly understood.We employ molecular dynamics simulations to elucidate how salinity variations in ore-forming fluids modulate the adsorption onto calcite nanopore walls,thereby revealing the microscopic mechanisms governing ore fluid transport through calcite nano-fractures.The results show that the adsorption energy Eint of the solution on the calcite surface increased from -14,948.84±182.48 kcal/mol to -12,144.08±118.2 kcal/mol as salinity increased,which is conducive to the long-range transport of the fluid in the calcite nanopore.展开更多
The purpose of the present investigation is to explore the implications of Cross fluid in a Darcy-Forchheimer porousmediumdue to the tri-hybrid nanofluid past a porous cylinder.Thermal radiation,heat generation,therma...The purpose of the present investigation is to explore the implications of Cross fluid in a Darcy-Forchheimer porousmediumdue to the tri-hybrid nanofluid past a porous cylinder.Thermal radiation,heat generation,thermal convection,solutal convective and chemical reaction have been encountered in this analysis.Entropy generation has been accounted for under the fluidic friction,heat rate analysis,and porosity analysis.Three different nanoparticles of multiwall carbon nanotube(MWCNT),aluminum oxide(Al_(2)O_(3)),and silver(Ag)are utilized to illustrate the tri-hybrid nanofluid flow with Ethlene Glycol(EG)as the base fluid.The governance model,consisting of linked inadequate differential conditions,is transformed into an ordinary configuration of nonlinear coupled differential conditions by acceptable adjustments.The obtained outcomes in combination with the bvp4c approach are then used to resolve the generated ODEs.For discussion purposes,the impacts of the physical limitations on temperature profile,velocity,and concentration have also been illustrated.Numerical results have been obtained for the diffusion rate,heat transfer rate,drag force,and other factors.While the Forchheimer parameter and the inclination angle reduce the fluid flow’s velocity,the Biot number of heat and mass transfer influences the fluid’s temperature.According to the findings,hybrid nanofluid is the most effective way to improve heat transmission and may also be utilized for cooling.Three different kinds of nanofluids were used in a comparative examination to clarify the study’s conclusions.Changes in viscosity and porousness caused the nanofluids’velocity to drop by 13.12%and 15.8%,respectively;however,trihybrid nanofluids with improved convection showed a 13.12%rise.展开更多
High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging ...High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).展开更多
While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model...While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.展开更多
There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reac...There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reactive coating processes,but existing work is not uncharacteristically remiss regarding viscoelasticity,radiative heating,viscous dissipation,and homogeneous–heterogeneous reactions within a single scheme that is calibrated.This research investigates the flow of Williamson nanofluid across a dynamically wedged surface under conditions that include viscous dissipation,thermal radiation,and homogeneous-heterogeneous reactions.The paper develops a detailed mathematical approach that utilizes boundary layers to transform partial differential equations into ordinary differential equations using similarity transformations.RK4 is the technique for gaining numerical solutions,but with the addition of ANNs,there is an improvement in prediction accuracy and computational efficiency.The study investigates the influence of wedge angle parameter,along with Weissenberg number,thermal radiation parameter and Brownian motion parameter,and Schmidt number,on velocity distribution,temperature distribution,and concentra-tion distribution.Enhanced Weissenberg numbers enhance viscoelastic responses that modify velocity patterns,but radiation parameters and thermophoresis have key impacts on thermal transfer phenomena.This research develops findings that are of enormous application in aerospace,biomedical(artificial hearts and drug delivery),and industrial cooling technology applications.New findings on non-Newtonian nanofluids under full flow systems are included in this work to enhance heat transfer methods in novel fluid-based systems.展开更多
Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly b...Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity,cost-effectiveness,and rapid detection.Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids.Despite the significant progress,rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations,such as large errors and the inability to quantify and accurately detect.New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence,afterglow,and chemiluminescence.Herein,we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources.Moreover,the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.展开更多
文摘The tight sandstone reservoirs in the first sub-member of Chang 7 member(Chang 71)of Triassic Yanchang Formation in the Jiyuan area,Ordos Basin,show significant variations in microscopic pore-throat structure(PTS)and fluid mobility due to the influences of the northeast and northwest dual provenance systems.This study performed multiple experimental analyses on nine samples from the area to determine the petrological and petrophysical properties,as well as the PTS characteristics of reservoirs in different provenance-controlled regions.On this basis,the pore-throat size distribution(PSD)obtained from high-pressure mercury injection(HPMI)was utilized to convert the NMR movable fluid T2spectrum,allowing for quantitative characterization of the full PSD and the occurrence characteristics of movable fluids.A systematic analysis was conducted on the primary controlling factors affecting fluid mobility in the reservoir.The results indicated that the lithology in the eastern and western regions is lithic arkose.The eastern sandstones,being farther from the provenance,exhibit higher contents of feldspar and lithic fragments,along with the development of more dissolution pores.The reservoir possesses good petrophysical properties,low displacement pressure,and high pore-throat connectivity and homogeneity,indicating strong fluid mobility.In contrast,the western sandstones,being nearer to the provenance,exhibit poor grain sorting,high contents of lithic fragments,strong compaction and cementation effects,resulting in poor petrophysical properties,and strong pore-throat heterogeneity,revealing weak fluid mobility.The range of full PSD in the eastern reservoir is wider than that in the western reservoir,with relatively well-developed macropores.The macropores are the primary space for occurrence of movable fluids,and controls the fluid mobility of the reservoir.The effective porosity of movable fluids(EPMF)quantitatively represents the pore space occupied by movable fluids within the reservoir and correlates well with porosity,permeability,and PTS parameters,making it a valuable parameter for evaluating fluid mobility.Under the multi-provenance system,the eastern and western reservoirs underwent different sedimentation and diagenesis processes,resulting in differential distribution of reservoir mineral components and pore types,which in turn affects the PTS heterogeneity and reservoir quality.The composition and content of reservoir minerals are intrinsic factors influencing fluid mobility,while the microscopic PTS is the primary factor controlling it.Low clay mineral content,welldeveloped macropores,and weak pore-throat heterogeneity all contribute to the storage and seepage of reservoir fluids.
基金the financial support from the National Science and Technology Major Project of China(2024XXXXX2700)the National Natural Science Foundation of China (22408099)+1 种基金the Key Research and Development Program of Xinjiang Uygur Autonomous Region (2022B01032)the National Ten Thousand Talents Program。
文摘This study presents a theoretical and experimental analysis of laminar flow behavior of high-viscous non-Newtonian power-law and Bingham fluids in multiple structural bifurcation channel distributors.Theoretical models are derived to describe velocity profiles,shear rate distribution,and pressure drop across specific channels.Modified pressure drop models are proposed based on experiments on 6 kinds of non-Newtonian fluids and 3 types of bifurcation channel distributors with different transition areas.Specifically,the deviations between the theoretical models and the experimental results are systematically analyzed,and models were modified with correction coefficients based on Reynolds number and dimensionless shape factor.The theoretical results,modified results and experimental data are compared and discussed to ensure the accuracy of the modified models,demonstrating a significant improvement in the prediction of pressure drops for high-viscous non-Newtonian fluids in certain types of bifurcation channels.Additional experiments and analyses were carried out to validate the modified models and the results suggest that the models offer a certain degree of universal applicability in bifurcation channel designs.It implies that for other types of bifurcation channel distributors,similar correction methods based on Reynolds number and shape factor may also be applicable even with different coefficients.
基金sponsorship of the National Natural Science Foundation of China (U24B2020,42174139)。
文摘The wave-induced fluid flow(WIFF) occurring in the ubiquitous layered porous media(e.g.,shales)usually causes the appreciable seismic energy dissipation,which further leads to the frequency dependence of wave velocity(i.e.,dispersion) and elastic anisotropy parameters.The relevant knowledge is of great importance for geofluid discrimination and hydrocarbon exploration in the porous shale reservoirs.We derive the wave equations for a periodic layered transversely isotropy medium with a vertical axis of symmetry(VTI) concurrently with the annular cracks(PLPC medium) based on the periodic-layered model and anisotropic Biot's theory,which simultaneously incorporate the effects of microscopic squirt fluid flow,mesoscopic interlayer fluid flow and macroscopic global fluid flow.Notably,the microscopic squirt shorten fluid flow emerges between the annular-shaped cracks and stiff pores,which generates one attenuation peak.Specifically,we first establish the stress-strain relationship and pore fluid pressure in a PLPC medium,and then use them to derive the wave equations by means of the Newton's second law.The plane analysis is implemented on the wave equations to yield the analytic solutions for phase velocities and attenuation factors of four waves,namely,fast P-wave,slow P-wave,SV-wave and SH-wave,and the anisotropy parameters can be therefore computed.Simulation results show that P-wave velocity have three attenuation peaks throughout the full frequency band,which respectively correspond to the influences of interlayer flow,the squirt flow and the Biot flow.Through the results of seismic velocity dispersion and attenuation at different incident angles,we find that the WIFF mechanism also has a significant impact on the dispersion characteristics of elastic anisotropy parameters within the low-mid frequency band.Moreover,it is shown that several poroelastic parameters,such as layer thickness ratio,crack aspect ratio and crack density have notable influence on seismic dispersion and attenuation.We compare the proposed modeled velocities with that given by the existing theory to confirm its validity.Our formulas and result can provide a better understanding of wave propagation in PLPC medium by considering the unified impacts of micro-,meso-and macro-scale WIFF mechanisms,which potentially lays a theoretical basis of rock physics for seismic interpretation.
文摘In the version of the article originally published in the volume 68,issue 12,2025 of Sci China Mater(pages 4413-4422,https://doi.org/10.1007/s40843-025-3667-7),the Chinese name of the co-first author(肖天孝)was incorrect.The corrected Chinese name is:肖天笑.
文摘Researchers are increasingly focused on enabling groups of multiple unmanned vehicles to operate cohesively in complex,real-world environments,where coordinated formation control and obstacle avoidance are essential for executing sophisticated collective tasks.This paper presents a Distributed Formation Control and Obstacle Avoidance(DFCOA)framework for multi-unmanned ground vehicles(UGV).DFCOA integrates a virtual leader structure for global guidance,an improved A^(*)path planning algorithm with an advanced cost function for efficient path planning,and a repulsive-force-based improved vector field histogram star(VFH^(*))technique for collision avoidance.The virtual leader generates a reference trajectory while enabling distributed execution;the improved A^(*)algorithm reduces planning time and number of nodes to determine the shortest path from the starting position to the goal;and the improved VFH^(*)uses 2D LiDAR data with inter-agent repulsive force to simultaneously avoid collision with obstacles and maintain safe inter-vehicle distances.The formation stability of the proposed DFCOA reaches 95.8%and 94.6%in two scenarios,with root mean square(RMS)centroid errors of 0.9516 and 1.0008 m,respectively.Velocity tracking is precise(velocity centroid error RMS of 0.2699 and 0.1700 m/s),and linear velocities closely match the desired 0.3 m/s.Safety metrics showed average collision risks of 0.7773 and 0.5143,with minimum inter-vehicle distances of 0.4702 and 0.8763 m,confirming collision-free navigation of four UGVs.DFCOA outperforms conventional methods in formation stability,path efficiency,and scalability,proving its suitability for decentralized multi-UGV applications.
基金supported by the confidential research grant No.a8317。
文摘To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions.
文摘Rhegmatogenous retinal detachment(RRD)is a serious ocular condition marked by the separation of the neuroretina from the retinal pigment epithelium(RPE).The pathogenesis of RRD involves intricate molecular and cellular mechanisms,including inflammation,cell migration,and the activation of proliferative signaling pathways.One of the most challenging complications of RRD is proliferative vitreoretinopathy(PVR),which refers to the proliferation and contraction of fibrocellular membranes on the retinal surface and in the vitreous cavity.PVR is a major cause of surgical failure in RRD,as it can lead to recurrent retinal detachment and severe vision loss.However,the pathogenesis of PVR is not yet fully understood,and the treatment options are quite limited.Recent advances in analytical techniques have offered valuable insights into the molecular alterations present in the subretinal fluid(SRF)of patients with RRD.This review seeks to consolidate the current knowledge regarding the SRF profile in RRD and PVR,emphasizing potential biomarkers and therapeutic targets.
基金jointly funded by the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDA0430301)the National Natural Science Foundation of China(grant Nos.42130109,41973059)。
文摘The formation of copper deposits is closely related to hydrothermal processes.Understanding the migration of copper in hydrothermal fluids aids in reconstructing mineralization processes and deciphering deposit genesis.Copper primarily exists as Cu^(+)and Cu^(2+)in hydrothermal solutions,with redox conditions governing their interconversion.In chloride-rich geological fluids,Cu-Cl complexes are considered critical for copper transport.However,the specific types and valence transitions of Cu-Cl complexes under varying hydrothermal conditions remain poorly understood.This study employed in situ Raman spectroscopy to systematically analyze Cu+HCl and CuCl_(2)+K_(2)S_(2)O_(3)/H_(2) systems under saturated vapor pressure at 25-300℃,elucidating the effects of temperature,Cl^(-)concentration,and redox conditions on copper speciation.In the Cu^(+)HCl system,copper dissolved as monovalent Cu-Cl complexes.At high temperatures(>200℃),[CuCl_(2)]^(-)is the dominated species,whereas[CuCl_(3)]^(2-)becomes prevalent at lower temperatures and higher HCl concentrations.For the Cu^(2+)-Cl system,the dominant species transitioned from[Cu(H_(2)O)n]^(2+)(<50℃)to[CuCl_(4)]^(2-)(100℃)and further to[CuCl]^(+)and[CuCl_(2)]^(0) at 300℃.The introduction of reducing agents(K_(2)S_(2)O_(3)/H_(2))facilitated Cu^(2+)→Cu^(+)reduction,thereby stabilizing Cu^(+)-Cl complexes and inducing partial copper precipitation.The behavior of copper in chloriderich hydrothermal fluids observed in this study indicates that high-temperature oxidizing fluids facilitate Cu mobilization,while cooling and redox changes promote deposition and ore minerals formation.
基金supported by the National Natural Science Foundation of China(No.12372233)the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University,China(No.25GH01020005)the“111 Project”of China(No.B17037)。
文摘As a multidisciplinary phenomenon,panel aeroelasticity in shock-dominated flow is featured by two primary interactions:Fluid-Structure Interactions(FSIs)and Shock-Boundary Layer Interactions(SBLIs).The former raises structural concerns,and the latter is of aerodynamic interest.Thus,panel aeroelasticity in shock-dominated flow represents a vital topic for the development and optimization of supersonic vehicles and propulsion systems.This review systematically summarizes recent advances in the methodologies applied to capture structural and fluid dynamics,including theoretical models,numerical simulations,and wind tunnel experiments.The application of data-driven modal decomposition,an advanced technique to extract physically crucial features,on the topic is introduced.From the perspective of FSIs,the distinctive aeroelastic behaviors in shock-dominated flow,including hysteresis phenomena and nonlinear responses,are highlighted.From the perspective of SBLIs,the modifications in their spatial and temporal characteristics imposed by the aeroelastic responses are emphasized.Motivated by the interaction between the shock waves and structural response,different strategies have been proposed to implement aeroelastic suppression and shock control,which have the potential to enhance structural safety and aerodynamic performance in the next generation of high-speed flight vehicles.
文摘When a porous rock is subjected to overall compressive loading,either increasing pore pressure or decreasing confining pressure could result in rock failure.The stress path and the applied pressure change rate may affect the initiation and propagation of fractures within brittle materials.Understanding the physical mechanisms leading to failure is crucial for underground engineering applications and geo-energy exploration and storage.We conducted triaxial compression experiments on porous Bentheim sandstone samples at different stress paths and pressure change rates.First,at a constant confining pressure of 35 MPa and pore pressure of 5 MPa,intact cylindrical samples were axially loaded up to about 85%of the peak strength.Subsequently,the axial piston position was fixed,and then either the pore pressure was increased or the confining pressure was decreased at two different rates(0.5 MPa/min or 2 MPa/min),leading to final catastrophic failure.The mechanical results revealed that samples subjected to higher rates of decreasing effective confining pressure exhibited larger stress drop rates,higher slip rates,higher total breakdown work,higher rates of acoustic emissions(AEs)before failure,and higher post-failure AE decay rates.In contrast,the applied stress path did not significantly affect rock failure characteristics.Comparison of located AE events with post-mortem microstructures of deformed samples shows a good agreement.The AE source type determined from the P-wave first-motion polarity shows that shear failure dominated the fracture process when approaching failure.Gutenberg-Richter b-values revealed a significant decrease before failure in all tests.Our results indicate that,in contrast to the stress path,the rate of effective stress change strongly affects fracturing behavior and AE rate changes.
基金supported by the grants from the Key Research and Development Program of Xinjiang Uygur autonomous region in China(Grant No.2023B02017)the National Key Research and Development Program of China(Grant No.2024YFD2300703)+1 种基金the financial support from the Beijing Rural Revitalization Agricultural Science and Technology Project(Grant No.NY2401080000),BAIC01-2025the 2115 Talent Development Program of China Agricultural University.
文摘Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging complex networks and interacting with other phytohormones(Liu et al.,2022;Khan et al.,2023).Although phytomelatonin receptors(PMTRs)have been identified in many plants(Wei et al.,2018;Wang et al.,2022;Liu et al.,2025),the downstream signaling mechanisms,particularly receptor-mediated protein modifications and transcriptional regulation,remain poorly characterized.
基金financed jointly by the National Major Science and Technology Special Project on Deep Earth Exploration(2024ZD1001701-5)the National Natural Science Foundation of China(42472127,42172086)+2 种基金the Yunnan Major Project of Basic Research(202401BN070001-002)Yunnan Mineral Resources Prediction and Evaluation Engineering Research Center(2011)Innovation Team Program of Kunming University of Science and Technology,Yunnan Province。
文摘The migration mechanisms of ore-forming fluids have long been a focus in the field of ore deposit studies.Calcite is ubiquitously present in various types of rocks in the lithosphere,and the underlying mechanisms of its influence on fluid migration are of crucial importance.While previous studies have revealed that salinity changes can modulate fluid migration,the underlying mechanisms remain poorly understood.We employ molecular dynamics simulations to elucidate how salinity variations in ore-forming fluids modulate the adsorption onto calcite nanopore walls,thereby revealing the microscopic mechanisms governing ore fluid transport through calcite nano-fractures.The results show that the adsorption energy Eint of the solution on the calcite surface increased from -14,948.84±182.48 kcal/mol to -12,144.08±118.2 kcal/mol as salinity increased,which is conducive to the long-range transport of the fluid in the calcite nanopore.
基金the research support through grants ANTARABANGSA(IRMG)-TEL-U/2025/FTKM/A00086.
文摘The purpose of the present investigation is to explore the implications of Cross fluid in a Darcy-Forchheimer porousmediumdue to the tri-hybrid nanofluid past a porous cylinder.Thermal radiation,heat generation,thermal convection,solutal convective and chemical reaction have been encountered in this analysis.Entropy generation has been accounted for under the fluidic friction,heat rate analysis,and porosity analysis.Three different nanoparticles of multiwall carbon nanotube(MWCNT),aluminum oxide(Al_(2)O_(3)),and silver(Ag)are utilized to illustrate the tri-hybrid nanofluid flow with Ethlene Glycol(EG)as the base fluid.The governance model,consisting of linked inadequate differential conditions,is transformed into an ordinary configuration of nonlinear coupled differential conditions by acceptable adjustments.The obtained outcomes in combination with the bvp4c approach are then used to resolve the generated ODEs.For discussion purposes,the impacts of the physical limitations on temperature profile,velocity,and concentration have also been illustrated.Numerical results have been obtained for the diffusion rate,heat transfer rate,drag force,and other factors.While the Forchheimer parameter and the inclination angle reduce the fluid flow’s velocity,the Biot number of heat and mass transfer influences the fluid’s temperature.According to the findings,hybrid nanofluid is the most effective way to improve heat transmission and may also be utilized for cooling.Three different kinds of nanofluids were used in a comparative examination to clarify the study’s conclusions.Changes in viscosity and porousness caused the nanofluids’velocity to drop by 13.12%and 15.8%,respectively;however,trihybrid nanofluids with improved convection showed a 13.12%rise.
文摘High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).
基金funded by Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20671)the Major Project of Inner Mongolia Science and Technology(Grant No.2021ZD0034)the Creative Groups of Natural Science Foundation of Hubei Province,China(Grant No.2021CFA030).
文摘While injection-induced seismicity has been widely studied,its implications for CO_(2)geological storage require reevaluation due to distinct fluid-rock interactions.This study develops a coupled hydromechanical model incorporating rate-and-state friction laws to investigate fault reactivation mechanisms during early-stage CO_(2)injection.The competing effects of pore pressure diffusion and fluid pressurization are systematically investigated,considering three key factors:permeability variations within fault damage zones,normal stress variation coefficients,and injection parameters.Numerical simulations reveal that slower CO_(2)migration causes limited pressure perturbation(<0.3 MPa over 15 d)compared to single-phase fluid injection.Fluid pressurization enhances fault strength and delays reactivation,though this stabilizing effect diminishes in low-permeability damage zones.Highly permeable damage zones promote larger rupture areas despite strengthening from pressurization,as reduced effective stress accelerates failure.Paradoxically,while fluid pressurization increases fault strength,it simultaneously elevates seismic risk through amplified stress drops during slip events.Temporal analysis shows that fluid pressurization dominates initial fault response,while sustained pore pressure diffusion ultimately drives reactivation.Increased normal stress variation coefficients and injection rates accelerate localized rupture initiation but restrict propagation due to non-critically stressed states.This discrepancy demonstrates that regions with positive Coulomb failure stress changes do not correlate well with actual slip zones.These findings highlight the critical interplay between transient pressurization effects and progressive pressure diffusion during early CO_(2)injection phases,providing crucial insights for seismic risk management in CO_(2)storage projects.
基金supported by the Korea Institute of Energy Technology Evaluation and Planning(KETEP)and the Ministry of Trade,Industry&Energy(MOTIE)of the Republic of Korea(No.RS-2025-02315209).
文摘There is a need for accurate prediction of heat and mass transfer in aerodynamically designed,non-Newtonian nanofluids across aerodynamically designed,high-flux biomedical micro-devices for thermal management and reactive coating processes,but existing work is not uncharacteristically remiss regarding viscoelasticity,radiative heating,viscous dissipation,and homogeneous–heterogeneous reactions within a single scheme that is calibrated.This research investigates the flow of Williamson nanofluid across a dynamically wedged surface under conditions that include viscous dissipation,thermal radiation,and homogeneous-heterogeneous reactions.The paper develops a detailed mathematical approach that utilizes boundary layers to transform partial differential equations into ordinary differential equations using similarity transformations.RK4 is the technique for gaining numerical solutions,but with the addition of ANNs,there is an improvement in prediction accuracy and computational efficiency.The study investigates the influence of wedge angle parameter,along with Weissenberg number,thermal radiation parameter and Brownian motion parameter,and Schmidt number,on velocity distribution,temperature distribution,and concentra-tion distribution.Enhanced Weissenberg numbers enhance viscoelastic responses that modify velocity patterns,but radiation parameters and thermophoresis have key impacts on thermal transfer phenomena.This research develops findings that are of enormous application in aerospace,biomedical(artificial hearts and drug delivery),and industrial cooling technology applications.New findings on non-Newtonian nanofluids under full flow systems are included in this work to enhance heat transfer methods in novel fluid-based systems.
基金supported by the National Natural Science Foundation of China (Nos.22234005,22494632,22404081)the Natural Science Foundation of Jiangsu Province (Nos.BK20222015,BK20240534)。
文摘Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity,cost-effectiveness,and rapid detection.Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids.Despite the significant progress,rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations,such as large errors and the inability to quantify and accurately detect.New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence,afterglow,and chemiluminescence.Herein,we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources.Moreover,the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.
