Researchers are increasingly focused on enabling groups of multiple unmanned vehicles to operate cohesively in complex,real-world environments,where coordinated formation control and obstacle avoidance are essential f...Researchers are increasingly focused on enabling groups of multiple unmanned vehicles to operate cohesively in complex,real-world environments,where coordinated formation control and obstacle avoidance are essential for executing sophisticated collective tasks.This paper presents a Distributed Formation Control and Obstacle Avoidance(DFCOA)framework for multi-unmanned ground vehicles(UGV).DFCOA integrates a virtual leader structure for global guidance,an improved A^(*)path planning algorithm with an advanced cost function for efficient path planning,and a repulsive-force-based improved vector field histogram star(VFH^(*))technique for collision avoidance.The virtual leader generates a reference trajectory while enabling distributed execution;the improved A^(*)algorithm reduces planning time and number of nodes to determine the shortest path from the starting position to the goal;and the improved VFH^(*)uses 2D LiDAR data with inter-agent repulsive force to simultaneously avoid collision with obstacles and maintain safe inter-vehicle distances.The formation stability of the proposed DFCOA reaches 95.8%and 94.6%in two scenarios,with root mean square(RMS)centroid errors of 0.9516 and 1.0008 m,respectively.Velocity tracking is precise(velocity centroid error RMS of 0.2699 and 0.1700 m/s),and linear velocities closely match the desired 0.3 m/s.Safety metrics showed average collision risks of 0.7773 and 0.5143,with minimum inter-vehicle distances of 0.4702 and 0.8763 m,confirming collision-free navigation of four UGVs.DFCOA outperforms conventional methods in formation stability,path efficiency,and scalability,proving its suitability for decentralized multi-UGV applications.展开更多
Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo stru...Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo structure. Beyond the proton dripline, nuclei become unbound, allowing protons to be emitted and giving rise to novel radioactive decay modes. Single-proton radioactivity, a process in which some nuclei with an odd number of protons(Z) decay by ejecting a proton, was discovered several decades ago and has been extensively studied [1, 2].展开更多
Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the ...Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.展开更多
Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present so...Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.展开更多
Dear Editor,This letter investigates predefined-time optimization problems(OPs) of multi-agent systems(MASs), where the agent of MASs is subject to inequality constraints, and the team objective function accounts for ...Dear Editor,This letter investigates predefined-time optimization problems(OPs) of multi-agent systems(MASs), where the agent of MASs is subject to inequality constraints, and the team objective function accounts for impulse effects. Firstly, to address the inequality constraints,the penalty method is introduced. Then, a novel optimization strategy is developed, which only requires that the team objective function be strongly convex.展开更多
Dear Editor,This letter studies a real-world issue in leader-follower multi-agent systems(MASs)named open topology,which permits the variations of agent set and network connections.Specially,a novel transition process...Dear Editor,This letter studies a real-world issue in leader-follower multi-agent systems(MASs)named open topology,which permits the variations of agent set and network connections.Specially,a novel transition process is developed to explain how the involved variation of network scale affects the dynamic behavior of the MASs.From a resource limited perspective,the distributed saturated impulsive control is then designed,under which some sufficient criteria are integrated into local quasi-consensus performance.We also provide a combined optimization algorithm for all agents to make the estimated domain of initial errors closer to the real one,thereby resulting in less conservativeness.Finally,a numerical example validates our results.展开更多
Dear Editor,Through distributed machine learning,multi-UAV systems can achieve global optimization goals without a centralized server,such as optimal target tracking,by leveraging local calculation and communication w...Dear Editor,Through distributed machine learning,multi-UAV systems can achieve global optimization goals without a centralized server,such as optimal target tracking,by leveraging local calculation and communication with neighbors.In this work,we implement the stochastic gradient descent algorithm(SGD)distributedly to optimize tracking errors based on local state and aggregation of the neighbors'estimation.However,Byzantine agents can mislead neighbors,causing deviations from optimal tracking.We prove that the swarm achieves resilient convergence if aggregated results lie within the normal neighbors'convex hull,which can be guaranteed by the introduced centerpoint-based aggregation rule.In the given simulated scenarios,distributed learning using average,geometric median(GM),and coordinate-wise median(CM)based aggregation rules fail to track the target.Compared to solely using the centerpoint aggregation method,our approach,which combines a pre-filter with the centroid aggregation rule,significantly enhances resilience against Byzantine attacks,achieving faster convergence and smaller tracking errors.展开更多
The multi-objective optimization problems,especially in constrained environments such as power distribution planning,demand robust strategies for discovering effective solutions.This work presents the improved variant...The multi-objective optimization problems,especially in constrained environments such as power distribution planning,demand robust strategies for discovering effective solutions.This work presents the improved variant of the Multi-population Cooperative Constrained Multi-Objective Optimization(MCCMO)Algorithm,termed Adaptive Diversity Preservation(ADP).This enhancement is primarily focused on the improvement of constraint handling strategies,local search integration,hybrid selection approaches,and adaptive parameter control.Theimproved variant was experimented on with the RWMOP50 power distribution systemplanning benchmark.As per the findings,the improved variant outperformed the original MCCMO across the eleven performance metrics,particularly in terms of convergence speed,constraint handling efficiency,and solution diversity.The results also establish that MCCMOADP consistently delivers substantial performance gains over the baseline MCCMO,demonstrating its effectiveness across performancemetrics.The new variant also excels atmaintaining the balanced trade-off between exploration and exploitation throughout the search process,making it especially suitable for complex optimization problems in multiconstrained power systems.These enhancements make MCCMO-ADP a valuable and promising candidate for handling problems such as renewable energy scheduling,logistics planning,and power system optimization.Future work will benchmark the MCCMO-ADP against widely recognized algorithms such as NSGA-Ⅱ,NSGA-Ⅲ,and MOEA/D and will also extend its validation to large-scale real-world optimization domains to further consolidate its generalizability.展开更多
The complex aerodynamic interaction between tandem tilt-wing and multi-rotor directly affects the wing surface flow and rotor thrust,making it a critical factor during the tilt transition process of this configuration...The complex aerodynamic interaction between tandem tilt-wing and multi-rotor directly affects the wing surface flow and rotor thrust,making it a critical factor during the tilt transition process of this configuration of rotorcraft.The aerodynamic interaction of tandem tilt-wing and multi-rotor is investigated based on the CFD method.The aerodynamic effect of multi tilt-rotor is simulated as virtual disk modeling by adding source terms to the Navier-Stokes equations,effectively reducing the calculation time while maintaining the accuracy of aerodynamic interaction calculations.Aerodynamic forces and flow field characteristics of the tandem tilt-wing and multi-rotor under different tilt angles are compared between cases with and without aerodynamic interaction.Furthermore,the differences in aerodynamic forces between dynamic tilt transition and fixed-angle conditions were compared.The results show that the aerodynamic interaction of multi-rotor obviously increases the lift of front tilt-wing at different tilt angles,the wing lift under interaction is increased by more than 40%compared with isolated wing at tilt angle of 15°for the computation in this paper,which is related to the increase of wing flow velocity and the suppression of flow separation caused by multi-rotor;the wing blocking effect will increase rotor thrust,especially near the tilt angles of 30°and 45°;the increases of rear wing lift and rear rotor thrust under aerodynamic interaction are not significant because of suppression by the front wing’s downwash;the unsteady effects during dynamic tilting have a relatively minor impact on aerodynamic interaction,with the aerodynamic forces on the rotors and wings during the dynamic tilting process showing little difference from those under corresponding fixed tilt angles.展开更多
The pursuit of simultaneously high wear resistance and excellent lubrication in multi‐principal element alloy(MPEA)composites is often hindered by a fundamental trade‐off,which is exacerbated by the agglomeration of...The pursuit of simultaneously high wear resistance and excellent lubrication in multi‐principal element alloy(MPEA)composites is often hindered by a fundamental trade‐off,which is exacerbated by the agglomeration of high‐content graphene reinforcements.This compromise becomes particularly severe in composites with high‐content graphene reinforcements,whose agglomeration leads to embrittlement and lubrication failure.Here,a flake powder-metallurgy strategy is developed to construct a self‐assembled lamellar structure in graphene/CoCrNi MPEA composites(Gr/MPEA_(AL)).This approach enables the uniform dispersion of a high graphene content(3.0 wt%),which is unattainable by conventional methods.The resulting composite exhibits a rare dual enhancement in performance:an order‐of‐magnitude improvement in wear resistance coupled with a low coefficient of friction.Intriguingly,the tribological behavior shows significant anisotropy,with optimal performance observed when sliding perpendicular to the lamellae.Through a multi‐scale methodology combining molecular dynamics simulations,finite element analysis,and systematic experiments,it is revealed that this exceptional performance stems from the synergy of high‐density deformation nanotwins,efficient strain delocalization,and abundant graphene‐derived lubricating sites.This work establishes a general paradigm for designing composite architectures that reconcile traditionally incompatible properties,offering broad implications for developing next‐generation structural materials with integrated mechanical robustness and surface functionality for safety‐critical applications.展开更多
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba...To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions.展开更多
High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging ...High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).展开更多
Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging ...Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging complex networks and interacting with other phytohormones(Liu et al.,2022;Khan et al.,2023).Although phytomelatonin receptors(PMTRs)have been identified in many plants(Wei et al.,2018;Wang et al.,2022;Liu et al.,2025),the downstream signaling mechanisms,particularly receptor-mediated protein modifications and transcriptional regulation,remain poorly characterized.展开更多
Amyotrophic lateral sclerosis(ALS)is a rapidly progressing neurodegenerative disease,leading to muscle weakness,paralysis and ultimately death due to respiratory failure.Currently licensed drugs have only very limited...Amyotrophic lateral sclerosis(ALS)is a rapidly progressing neurodegenerative disease,leading to muscle weakness,paralysis and ultimately death due to respiratory failure.Currently licensed drugs have only very limited effects on slowing down disease progression or biomarkers.Despite numerous successful preclinical analyses,most new drugs fail when translated to clinical trials(Petrov et al.,2017).This is believed to be,in part,due to the multilayer heterogeneity of ALS(e.g.,clinical,genetic,and molecular;Tzeplaeff et al.,2024).Studies integrating multi-omic data are still limited,making it difficult to fully understand the biological complexity that characterizes the disease.展开更多
Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technol...Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.展开更多
The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measu...The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measures in a multi-family house building in Greece.The energy efficiency measures include different heating/cooling systems(such as low-temperature and high-temperature heat pumps,natural gas boilers,split units),building envelope components for floor,walls,roof and windows of variable heat transfer coefficients,the installation of solar thermal collectors and PVs.The calculations of the building loads and investment and operating and maintenance costs of the measures are based on the methodology defined in Directive 2010/31/EU,while economic assumptions are based on EN 15459-1 standard.Typically,multi-objective optimization of energy efficiency measures often requires the simulation of very large numbers of cases involving numerous possible combinations,resulting in intense computational load.The results of the study indicate that ANN-driven GA methods can be used as an alternative,valuable tool for reliably predicting the optimal measures which minimize primary energy consumption and life cycle cost of the building with greatly reduced computational requirements.Through GA methods,the computational time needed for obtaining the optimal solutions is reduced by 96.4%-96.8%.展开更多
New electronic devices based on the physical properties of electrically driven skyrmions are promising for logic computing and nonvolatile memory applications.However,achieving efficient and practical compute-storage ...New electronic devices based on the physical properties of electrically driven skyrmions are promising for logic computing and nonvolatile memory applications.However,achieving efficient and practical compute-storage integration remains challenging owing to the structural complexity,limited functionality,and low flexibility observed in most skyrmion-based devices.In this study,we designed a novel device architecture that integrates seven basic logic gates into a unified physical structure.Their operation can be enabled by physical mechanisms,such as spin-orbit torque,spin-transfer torque,skyrmion-edge repulsions,and skyrmion-skyrmion interactions.Furthermore,by incorporating voltage-controlled magnetic anisotropy,the device achieved multi-input capability and reconfigurability functionality.Ultralow power consumption(<1 fJ/bit per logic function)and extremely high logic density were achieved.Significantly,the compatibility of this nanotrack design with existing skyrmion racetrack memory paves the way for advanced in-memory computing in spintronic architectures.展开更多
文摘Researchers are increasingly focused on enabling groups of multiple unmanned vehicles to operate cohesively in complex,real-world environments,where coordinated formation control and obstacle avoidance are essential for executing sophisticated collective tasks.This paper presents a Distributed Formation Control and Obstacle Avoidance(DFCOA)framework for multi-unmanned ground vehicles(UGV).DFCOA integrates a virtual leader structure for global guidance,an improved A^(*)path planning algorithm with an advanced cost function for efficient path planning,and a repulsive-force-based improved vector field histogram star(VFH^(*))technique for collision avoidance.The virtual leader generates a reference trajectory while enabling distributed execution;the improved A^(*)algorithm reduces planning time and number of nodes to determine the shortest path from the starting position to the goal;and the improved VFH^(*)uses 2D LiDAR data with inter-agent repulsive force to simultaneously avoid collision with obstacles and maintain safe inter-vehicle distances.The formation stability of the proposed DFCOA reaches 95.8%and 94.6%in two scenarios,with root mean square(RMS)centroid errors of 0.9516 and 1.0008 m,respectively.Velocity tracking is precise(velocity centroid error RMS of 0.2699 and 0.1700 m/s),and linear velocities closely match the desired 0.3 m/s.Safety metrics showed average collision risks of 0.7773 and 0.5143,with minimum inter-vehicle distances of 0.4702 and 0.8763 m,confirming collision-free navigation of four UGVs.DFCOA outperforms conventional methods in formation stability,path efficiency,and scalability,proving its suitability for decentralized multi-UGV applications.
文摘Introduction-Nuclei near and beyond the proton drip line represent a fascinating frontier in the nuclear landscape. Proton-rich nuclei exhibit intriguing phenomena, such as the Thomas-Ehrman shift and proton-halo structure. Beyond the proton dripline, nuclei become unbound, allowing protons to be emitted and giving rise to novel radioactive decay modes. Single-proton radioactivity, a process in which some nuclei with an odd number of protons(Z) decay by ejecting a proton, was discovered several decades ago and has been extensively studied [1, 2].
基金supported by the National Natural Science Foundation of China(62325304,U22B2046,62073079,62376029)the Jiangsu Provincial Scientific Research Center of Applied Mathematics(BK20233002)the China Postdoctoral Science Foundation(2023M730255,2024T171123)
文摘Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.
基金supported in part by the National Natural Science Foundation of China(62273255,62350003,62088101)the Shanghai Science and Technology Cooperation Project(22510712000,21550760900)+1 种基金the Shanghai Municipal Science and Technology Major Project(2021SHZDZX0100)the Fundamental Research Funds for the Central Universities
文摘Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.
基金supported in part by the National Natural Science Foundation of China(62276119)the Natural Science Foundation of Jiangsu Province(BK20241764)the Postgraduate Research & Practice Innovation Program of Jiangsu Province(KYCX22_2860)
文摘Dear Editor,This letter investigates predefined-time optimization problems(OPs) of multi-agent systems(MASs), where the agent of MASs is subject to inequality constraints, and the team objective function accounts for impulse effects. Firstly, to address the inequality constraints,the penalty method is introduced. Then, a novel optimization strategy is developed, which only requires that the team objective function be strongly convex.
基金supported by the Natural Science Foundation of Jiangsu Province(BK20240009)the National Natural Science Foundation of China(62373105,62373262)Jiangsu Provincial Scientific Research Center of Applied Mathematics(BK20233002).
文摘Dear Editor,This letter studies a real-world issue in leader-follower multi-agent systems(MASs)named open topology,which permits the variations of agent set and network connections.Specially,a novel transition process is developed to explain how the involved variation of network scale affects the dynamic behavior of the MASs.From a resource limited perspective,the distributed saturated impulsive control is then designed,under which some sufficient criteria are integrated into local quasi-consensus performance.We also provide a combined optimization algorithm for all agents to make the estimated domain of initial errors closer to the real one,thereby resulting in less conservativeness.Finally,a numerical example validates our results.
基金supported By Guangdong Major Project of Basic and Applied Basic Research(2023B0303000009)Guangdong Basic and Applied Basic Research Foundation(2024A1515030153,2025A1515011587)+1 种基金Project of Department of Education of Guangdong Province(2023ZDZX4046)Shen-zhen Natural Science Fund(Stable Support Plan Program 20231122121608001),Ningbo Municipal Science and Technology Bureau(ZX2024000604).
文摘Dear Editor,Through distributed machine learning,multi-UAV systems can achieve global optimization goals without a centralized server,such as optimal target tracking,by leveraging local calculation and communication with neighbors.In this work,we implement the stochastic gradient descent algorithm(SGD)distributedly to optimize tracking errors based on local state and aggregation of the neighbors'estimation.However,Byzantine agents can mislead neighbors,causing deviations from optimal tracking.We prove that the swarm achieves resilient convergence if aggregated results lie within the normal neighbors'convex hull,which can be guaranteed by the introduced centerpoint-based aggregation rule.In the given simulated scenarios,distributed learning using average,geometric median(GM),and coordinate-wise median(CM)based aggregation rules fail to track the target.Compared to solely using the centerpoint aggregation method,our approach,which combines a pre-filter with the centroid aggregation rule,significantly enhances resilience against Byzantine attacks,achieving faster convergence and smaller tracking errors.
文摘The multi-objective optimization problems,especially in constrained environments such as power distribution planning,demand robust strategies for discovering effective solutions.This work presents the improved variant of the Multi-population Cooperative Constrained Multi-Objective Optimization(MCCMO)Algorithm,termed Adaptive Diversity Preservation(ADP).This enhancement is primarily focused on the improvement of constraint handling strategies,local search integration,hybrid selection approaches,and adaptive parameter control.Theimproved variant was experimented on with the RWMOP50 power distribution systemplanning benchmark.As per the findings,the improved variant outperformed the original MCCMO across the eleven performance metrics,particularly in terms of convergence speed,constraint handling efficiency,and solution diversity.The results also establish that MCCMOADP consistently delivers substantial performance gains over the baseline MCCMO,demonstrating its effectiveness across performancemetrics.The new variant also excels atmaintaining the balanced trade-off between exploration and exploitation throughout the search process,making it especially suitable for complex optimization problems in multiconstrained power systems.These enhancements make MCCMO-ADP a valuable and promising candidate for handling problems such as renewable energy scheduling,logistics planning,and power system optimization.Future work will benchmark the MCCMO-ADP against widely recognized algorithms such as NSGA-Ⅱ,NSGA-Ⅲ,and MOEA/D and will also extend its validation to large-scale real-world optimization domains to further consolidate its generalizability.
基金supported by the National Key Laboratory of Helicopter Aeromechanics Fund(No.2024-CXPT-GF-JJ-093-05).
文摘The complex aerodynamic interaction between tandem tilt-wing and multi-rotor directly affects the wing surface flow and rotor thrust,making it a critical factor during the tilt transition process of this configuration of rotorcraft.The aerodynamic interaction of tandem tilt-wing and multi-rotor is investigated based on the CFD method.The aerodynamic effect of multi tilt-rotor is simulated as virtual disk modeling by adding source terms to the Navier-Stokes equations,effectively reducing the calculation time while maintaining the accuracy of aerodynamic interaction calculations.Aerodynamic forces and flow field characteristics of the tandem tilt-wing and multi-rotor under different tilt angles are compared between cases with and without aerodynamic interaction.Furthermore,the differences in aerodynamic forces between dynamic tilt transition and fixed-angle conditions were compared.The results show that the aerodynamic interaction of multi-rotor obviously increases the lift of front tilt-wing at different tilt angles,the wing lift under interaction is increased by more than 40%compared with isolated wing at tilt angle of 15°for the computation in this paper,which is related to the increase of wing flow velocity and the suppression of flow separation caused by multi-rotor;the wing blocking effect will increase rotor thrust,especially near the tilt angles of 30°and 45°;the increases of rear wing lift and rear rotor thrust under aerodynamic interaction are not significant because of suppression by the front wing’s downwash;the unsteady effects during dynamic tilting have a relatively minor impact on aerodynamic interaction,with the aerodynamic forces on the rotors and wings during the dynamic tilting process showing little difference from those under corresponding fixed tilt angles.
基金supported by Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012378)Natural Science Foundation of China(Nos.52471093,52274367)+3 种基金fund of the State Key Laboratory of Solidification Processing in NPU(No.2025‐QZ‐03)the Practice and Innovation Funds for Graduate Students of Northwestern Polytechnical University(No.PF2025041)Fundamental Research Projects of Science&Technology Innovation and development Plan in Yantai City(No.2024JCYJ099)project(No.ZR2024QE213)supported by Shandong Provincial Natural Science Foundation.
文摘The pursuit of simultaneously high wear resistance and excellent lubrication in multi‐principal element alloy(MPEA)composites is often hindered by a fundamental trade‐off,which is exacerbated by the agglomeration of high‐content graphene reinforcements.This compromise becomes particularly severe in composites with high‐content graphene reinforcements,whose agglomeration leads to embrittlement and lubrication failure.Here,a flake powder-metallurgy strategy is developed to construct a self‐assembled lamellar structure in graphene/CoCrNi MPEA composites(Gr/MPEA_(AL)).This approach enables the uniform dispersion of a high graphene content(3.0 wt%),which is unattainable by conventional methods.The resulting composite exhibits a rare dual enhancement in performance:an order‐of‐magnitude improvement in wear resistance coupled with a low coefficient of friction.Intriguingly,the tribological behavior shows significant anisotropy,with optimal performance observed when sliding perpendicular to the lamellae.Through a multi‐scale methodology combining molecular dynamics simulations,finite element analysis,and systematic experiments,it is revealed that this exceptional performance stems from the synergy of high‐density deformation nanotwins,efficient strain delocalization,and abundant graphene‐derived lubricating sites.This work establishes a general paradigm for designing composite architectures that reconcile traditionally incompatible properties,offering broad implications for developing next‐generation structural materials with integrated mechanical robustness and surface functionality for safety‐critical applications.
基金supported by the confidential research grant No.a8317。
文摘To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions.
文摘High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).
基金supported by the grants from the Key Research and Development Program of Xinjiang Uygur autonomous region in China(Grant No.2023B02017)the National Key Research and Development Program of China(Grant No.2024YFD2300703)+1 种基金the financial support from the Beijing Rural Revitalization Agricultural Science and Technology Project(Grant No.NY2401080000),BAIC01-2025the 2115 Talent Development Program of China Agricultural University.
文摘Phytomelatonin,an emerging plant hormone,plays vital roles in plant growth,development,and stress adaptation(Arnao et al.,2022;Ullah et al.,2024).It acts both as a direct antioxidant and a signaling molecule,engaging complex networks and interacting with other phytohormones(Liu et al.,2022;Khan et al.,2023).Although phytomelatonin receptors(PMTRs)have been identified in many plants(Wei et al.,2018;Wang et al.,2022;Liu et al.,2025),the downstream signaling mechanisms,particularly receptor-mediated protein modifications and transcriptional regulation,remain poorly characterized.
文摘Amyotrophic lateral sclerosis(ALS)is a rapidly progressing neurodegenerative disease,leading to muscle weakness,paralysis and ultimately death due to respiratory failure.Currently licensed drugs have only very limited effects on slowing down disease progression or biomarkers.Despite numerous successful preclinical analyses,most new drugs fail when translated to clinical trials(Petrov et al.,2017).This is believed to be,in part,due to the multilayer heterogeneity of ALS(e.g.,clinical,genetic,and molecular;Tzeplaeff et al.,2024).Studies integrating multi-omic data are still limited,making it difficult to fully understand the biological complexity that characterizes the disease.
基金supported by the Shenzhen Medical Research Fund(Grant No.A2303049)Guangdong Basic and Applied Basic Research(Grant No.2023A1515010647)+1 种基金National Natural Science Foundation of China(Grant No.22004135)Shenzhen Science and Technology Program(Grant No.RCBS20210706092409020,GXWD20201231165807008,20200824162253002).
文摘Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.
文摘The goal of the present work is to demonstrate the potential of Artificial Neural Network(ANN)-driven Genetic Algorithm(GA)methods for energy efficiency and economic performance optimization of energy efficiency measures in a multi-family house building in Greece.The energy efficiency measures include different heating/cooling systems(such as low-temperature and high-temperature heat pumps,natural gas boilers,split units),building envelope components for floor,walls,roof and windows of variable heat transfer coefficients,the installation of solar thermal collectors and PVs.The calculations of the building loads and investment and operating and maintenance costs of the measures are based on the methodology defined in Directive 2010/31/EU,while economic assumptions are based on EN 15459-1 standard.Typically,multi-objective optimization of energy efficiency measures often requires the simulation of very large numbers of cases involving numerous possible combinations,resulting in intense computational load.The results of the study indicate that ANN-driven GA methods can be used as an alternative,valuable tool for reliably predicting the optimal measures which minimize primary energy consumption and life cycle cost of the building with greatly reduced computational requirements.Through GA methods,the computational time needed for obtaining the optimal solutions is reduced by 96.4%-96.8%.
基金support from the National Natural Science Foundation of China (Grant No.12474101)support from the National Natural Science Foundation of China (Grant Nos.52272202 and W2421027)support from the National Natural Science Foundation of China (Grant No.52501307)。
文摘New electronic devices based on the physical properties of electrically driven skyrmions are promising for logic computing and nonvolatile memory applications.However,achieving efficient and practical compute-storage integration remains challenging owing to the structural complexity,limited functionality,and low flexibility observed in most skyrmion-based devices.In this study,we designed a novel device architecture that integrates seven basic logic gates into a unified physical structure.Their operation can be enabled by physical mechanisms,such as spin-orbit torque,spin-transfer torque,skyrmion-edge repulsions,and skyrmion-skyrmion interactions.Furthermore,by incorporating voltage-controlled magnetic anisotropy,the device achieved multi-input capability and reconfigurability functionality.Ultralow power consumption(<1 fJ/bit per logic function)and extremely high logic density were achieved.Significantly,the compatibility of this nanotrack design with existing skyrmion racetrack memory paves the way for advanced in-memory computing in spintronic architectures.
