While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals,efforts are still insufficient to develop analytical systems for detailed dynamic visualisat...While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals,efforts are still insufficient to develop analytical systems for detailed dynamic visualisation of foreign substances and material composition in target pills.Although spectroscopies,expected towards pharma testing,have faced technical challenges in in-line setups for bulky equipment housing,this work demonstrates compact dynamic photo-monitoring systems by selectively extracting informative irradiation-wavelengths from comprehensive optical references of target pills.This work develops a non-destructive in-line dynamic inspection system for pharma agent pills with carbon nanotube(CNT)photo-thermoelectric imagers and the associated ultrabroadband sub-terahertz(THz)–infrared(IR)multi-wavelength monitoring.The CNT imager in the proposed system functions in ultrabroadband regions over existing sensors,facilitating multi-wavelength photo-monitoring against external sub-THz–IR-irradiation.Under recent advances in the investigation of functional optical materials(e.g.,gallium arsenide,vanadium oxide,graphene,polymers,transition metal dichalcogenides),CNTs play advantageous leading roles in collectively satisfying informative efficient photo-absorption and solution-processable configurations for printable device fabrication into freely attachable thin-film imagers in pharma monitoring sites.The above non-destructive dynamic monitoring system maintains in-line experimental setups by integrating the functional thin-film imager sheets and compact multiple photo-sources.Furthermore,permeable sub-THz–IR-irradiation,which provides different transmittance values specific to non-metallic materials per wavelength or composition,identifies constituent materials for pharma agents themselves and concealed foreign substances in a non-contact manner.This work finally inspects invisible detailed features of pharma pills with the non-destructive in-line dynamic photo-monitoring system by incorporating performances of CNT imagers and compact optical setups.展开更多
To the Editor:Co-reactivation of cytomegalovirus(CMV)and Epstein–Barr virus(EBV)is common after haploidentical stem cell transplantation(haplo-SCT)and can lead to potentially life-threatening complications.[1,2]Adopt...To the Editor:Co-reactivation of cytomegalovirus(CMV)and Epstein–Barr virus(EBV)is common after haploidentical stem cell transplantation(haplo-SCT)and can lead to potentially life-threatening complications.[1,2]Adoptive immunotherapy with virus-specific T lymphocytes(VSTs)is a critical treatment option that has shown promising results in controlling CMV and EBV infections in several clinical studies,providing protection for 70–90%of patients.[3]Multi-virus-specific T cell lines offer an advanced method for simultaneously addressing multiple challenging viral infections.However,data regarding its long-term efficacy are limited.Additionally,clinical trials with multi-virus-specific T cells have predominantly focused on single virus reactivation,leaving gaps in our understanding of the effectiveness of VSTs during multivirus co-reactivation.Antigenic competition may affect the expansion of virus-specific T cells in vitro during the generation of multi-virus-specific cell lines.Whether in vivo competition among infused cells compromises the efficacy of adoptively transferred VSTs remains unclear.展开更多
基金supported by a part of ACT-X(JPMJAX23KL)and Mirai Program(JPMJMI23G1):JST,KAKENHI(JP22H01553,JP22H01555,JP23H00169,JP23K19125,JP24K01288,JP24K17325,and JP25H02154).
文摘While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals,efforts are still insufficient to develop analytical systems for detailed dynamic visualisation of foreign substances and material composition in target pills.Although spectroscopies,expected towards pharma testing,have faced technical challenges in in-line setups for bulky equipment housing,this work demonstrates compact dynamic photo-monitoring systems by selectively extracting informative irradiation-wavelengths from comprehensive optical references of target pills.This work develops a non-destructive in-line dynamic inspection system for pharma agent pills with carbon nanotube(CNT)photo-thermoelectric imagers and the associated ultrabroadband sub-terahertz(THz)–infrared(IR)multi-wavelength monitoring.The CNT imager in the proposed system functions in ultrabroadband regions over existing sensors,facilitating multi-wavelength photo-monitoring against external sub-THz–IR-irradiation.Under recent advances in the investigation of functional optical materials(e.g.,gallium arsenide,vanadium oxide,graphene,polymers,transition metal dichalcogenides),CNTs play advantageous leading roles in collectively satisfying informative efficient photo-absorption and solution-processable configurations for printable device fabrication into freely attachable thin-film imagers in pharma monitoring sites.The above non-destructive dynamic monitoring system maintains in-line experimental setups by integrating the functional thin-film imager sheets and compact multiple photo-sources.Furthermore,permeable sub-THz–IR-irradiation,which provides different transmittance values specific to non-metallic materials per wavelength or composition,identifies constituent materials for pharma agents themselves and concealed foreign substances in a non-contact manner.This work finally inspects invisible detailed features of pharma pills with the non-destructive in-line dynamic photo-monitoring system by incorporating performances of CNT imagers and compact optical setups.
基金funded by the National Key Research and Development Program of China(No.2022YFA0103300)Being Nova Program(No.20220484076)+2 种基金Major Program of the National Natural Science Foundation of China(Nos.82070184 and 82293630)Beijing Municipal Science&Technology Commission(No.Z211100002921071)Peking University Clinical Scientist Training Program(No.BMU2024PYJH012).
文摘To the Editor:Co-reactivation of cytomegalovirus(CMV)and Epstein–Barr virus(EBV)is common after haploidentical stem cell transplantation(haplo-SCT)and can lead to potentially life-threatening complications.[1,2]Adoptive immunotherapy with virus-specific T lymphocytes(VSTs)is a critical treatment option that has shown promising results in controlling CMV and EBV infections in several clinical studies,providing protection for 70–90%of patients.[3]Multi-virus-specific T cell lines offer an advanced method for simultaneously addressing multiple challenging viral infections.However,data regarding its long-term efficacy are limited.Additionally,clinical trials with multi-virus-specific T cells have predominantly focused on single virus reactivation,leaving gaps in our understanding of the effectiveness of VSTs during multivirus co-reactivation.Antigenic competition may affect the expansion of virus-specific T cells in vitro during the generation of multi-virus-specific cell lines.Whether in vivo competition among infused cells compromises the efficacy of adoptively transferred VSTs remains unclear.
