Objective To evaluate the effect of the aluminum hydroxide （Al-OH） adjuvant on the 2009 pandemic influenza A/H1N1 （pH1N1） vaccine. Methods In a multicenter, double-blind, randomized, placebo-controlled trial, part...Objective To evaluate the effect of the aluminum hydroxide （Al-OH） adjuvant on the 2009 pandemic influenza A/H1N1 （pH1N1） vaccine. Methods In a multicenter, double-blind, randomized, placebo-controlled trial, participants received two doses of split-virion formulation containing 15 ug hemagglutinin antigen, with or without aluminum hydroxide （N-OH）. We classified the participants into six age categories （〉61 years, 41-60 years, 19-40 years, 13-18 years, 8-12 years, and 3-7 years） and obtained four blood samples from each participant on days 0, 21, 35, and 42 following the first dose of immunization. We assessed vaccine immunogenicity by measuring the geometric mean titer （GMT） of hemagglutination inhibiting antibody. We used a two-level model to evaluate the fixed effect of aluminum Al-OH and other factors, accounting for repeated measures. Results The predictions of repeated measurement on GMTs of formulations with or without Al-OH, were 80.35 and 112.72, respectively. Al-OH significantly reduced immunogenicity after controlling for time post immunization, age-group and gender. Conclusion The Al-OH adjuvant does not increase but actually reduces the immunogenicity of the split-virion pH1N1 vaccine.展开更多
Multi-disciplinary virtual prototypes of complex products are increasingly and widely used in modern advanced manufactur- ing. How to effectively address the problems of unified modeling, composition and reuse based o...Multi-disciplinary virtual prototypes of complex products are increasingly and widely used in modern advanced manufactur- ing. How to effectively address the problems of unified modeling, composition and reuse based on the multi-disciplinary heteroge- neous models has brought great challenges to the modeling and simulation （M＆S） science and technology. This paper presents a top-level modeling theory based on the meta modeling framework （M2F） of the COllaborative SIMulation （COSlM） theory of virtual prototyping to solve the problems. Firstly the fundamental prin- ciples of the top-level modeling theory are decribed to expound the premise, assumptions, basic conventions and special require- ments in the description of complex heterogeneous systems. Next the formalized definitions for each factor in top level modeling are proposed and the hierarchical nature of them is illustrated. After demonstrating that they are self-closing, this paper divides the top- level modeling into two views, static structural graph and dynamic behavioral graph. Finally, a case study is discussed to demon- strate the feasibility of the theory.展开更多
This paper is a continuation of our last paper [1] which describes the theory of Virt-BLP model. Based on Virt-BLP model,this paper implements a mandatory access control(MAC) framework applicable to multi-level securi...This paper is a continuation of our last paper [1] which describes the theory of Virt-BLP model. Based on Virt-BLP model,this paper implements a mandatory access control(MAC) framework applicable to multi-level security(MLS) in Xen. The Virt-BLP model is the theoretical basis of this MAC framework,and this MAC framework is the implementation of Virt-BLP model. Our last paper focuses on Virt-BLP model,while this paper concentrates on the design and implementation of MAC framework. For there is no MAC framework applicable to MLS in virtual machine system at present,our MAC framework fills the blank by applying Virt-BLP model to Xen,which is better than current researches to guarantee the security of communication between virtual machines(VMs) . The experimental results show that our MAC framework is effective to manage the communication between VMs.展开更多
In order to study supply chain of the telecom value-added service,a multi-leaders and multi-followers Stackelberg game model with multiple telecom operators and multiple service providers whose income is composed of i...In order to study supply chain of the telecom value-added service,a multi-leaders and multi-followers Stackelberg game model with multiple telecom operators and multiple service providers whose income is composed of information fee division and advertisement was constructed.Then a demonstration was simulated,and the results were compared with the situation of service providers' income only from information fee division.The simulated and compared results indicate that,the enterprises in the supply chain have the nature of pursuing the maximum profits in capital markets;meanwhile,first-mover advantages and some enterprise can get more profits with the information asymmetry.展开更多
While Internet traffic is currently dominated by elastic data transfers, it is anticipated that streaming applications will rapidly develop and contribute a significant amount of traffic in the near future. Therefore,...While Internet traffic is currently dominated by elastic data transfers, it is anticipated that streaming applications will rapidly develop and contribute a significant amount of traffic in the near future. Therefore, it is essential to understand and capture the relation between streaming and elastic traffic behavior. In this paper, we focus on developing simple yet effective approximations to capture this relationship. We study, then, an analytical model to evaluate the end-to-end performance of elastic traffic under multi-queuing system. This model is based on the fluid flow approximation. We assume that network architecture gives the head of priority to real time traffic and shares the remaining capacity between the elastic ongoing flows according to a specific weight.展开更多
基金supported by the Infectious Disease Prevention and Control Major Research plan from the Ministry of Science and Technology of China-the Platform of Construction of Clinical Trial of Vaccine. (Project number 2009ZX0004-806)
文摘Objective To evaluate the effect of the aluminum hydroxide （Al-OH） adjuvant on the 2009 pandemic influenza A/H1N1 （pH1N1） vaccine. Methods In a multicenter, double-blind, randomized, placebo-controlled trial, participants received two doses of split-virion formulation containing 15 ug hemagglutinin antigen, with or without aluminum hydroxide （N-OH）. We classified the participants into six age categories （〉61 years, 41-60 years, 19-40 years, 13-18 years, 8-12 years, and 3-7 years） and obtained four blood samples from each participant on days 0, 21, 35, and 42 following the first dose of immunization. We assessed vaccine immunogenicity by measuring the geometric mean titer （GMT） of hemagglutination inhibiting antibody. We used a two-level model to evaluate the fixed effect of aluminum Al-OH and other factors, accounting for repeated measures. Results The predictions of repeated measurement on GMTs of formulations with or without Al-OH, were 80.35 and 112.72, respectively. Al-OH significantly reduced immunogenicity after controlling for time post immunization, age-group and gender. Conclusion The Al-OH adjuvant does not increase but actually reduces the immunogenicity of the split-virion pH1N1 vaccine.
基金supported by the National High Technology Research and Development Program (863 Program) (2011AA040502).
文摘Multi-disciplinary virtual prototypes of complex products are increasingly and widely used in modern advanced manufactur- ing. How to effectively address the problems of unified modeling, composition and reuse based on the multi-disciplinary heteroge- neous models has brought great challenges to the modeling and simulation （M＆S） science and technology. This paper presents a top-level modeling theory based on the meta modeling framework （M2F） of the COllaborative SIMulation （COSlM） theory of virtual prototyping to solve the problems. Firstly the fundamental prin- ciples of the top-level modeling theory are decribed to expound the premise, assumptions, basic conventions and special require- ments in the description of complex heterogeneous systems. Next the formalized definitions for each factor in top level modeling are proposed and the hierarchical nature of them is illustrated. After demonstrating that they are self-closing, this paper divides the top- level modeling into two views, static structural graph and dynamic behavioral graph. Finally, a case study is discussed to demon- strate the feasibility of the theory.
基金supported by National Key Basic Research and Development Plan (973 Plan) of China (No. 2007CB310900)National Natural Science Foundation of China (No. 90612018, 90715030 and 60970008)
文摘This paper is a continuation of our last paper [1] which describes the theory of Virt-BLP model. Based on Virt-BLP model,this paper implements a mandatory access control(MAC) framework applicable to multi-level security(MLS) in Xen. The Virt-BLP model is the theoretical basis of this MAC framework,and this MAC framework is the implementation of Virt-BLP model. Our last paper focuses on Virt-BLP model,while this paper concentrates on the design and implementation of MAC framework. For there is no MAC framework applicable to MLS in virtual machine system at present,our MAC framework fills the blank by applying Virt-BLP model to Xen,which is better than current researches to guarantee the security of communication between virtual machines(VMs) . The experimental results show that our MAC framework is effective to manage the communication between VMs.
基金supported by Research Start Fund of Northwest A&F University and Youth Fund of Communication University of China under Grant No.XNG1035partly performed in the project"On-line Multi-attribute Procurement Auction Mechanism Design and Multi-agent System Implementation"supported by National Natural Science Foundation of China under Grant No.71001009
文摘In order to study supply chain of the telecom value-added service,a multi-leaders and multi-followers Stackelberg game model with multiple telecom operators and multiple service providers whose income is composed of information fee division and advertisement was constructed.Then a demonstration was simulated,and the results were compared with the situation of service providers' income only from information fee division.The simulated and compared results indicate that,the enterprises in the supply chain have the nature of pursuing the maximum profits in capital markets;meanwhile,first-mover advantages and some enterprise can get more profits with the information asymmetry.
文摘While Internet traffic is currently dominated by elastic data transfers, it is anticipated that streaming applications will rapidly develop and contribute a significant amount of traffic in the near future. Therefore, it is essential to understand and capture the relation between streaming and elastic traffic behavior. In this paper, we focus on developing simple yet effective approximations to capture this relationship. We study, then, an analytical model to evaluate the end-to-end performance of elastic traffic under multi-queuing system. This model is based on the fluid flow approximation. We assume that network architecture gives the head of priority to real time traffic and shares the remaining capacity between the elastic ongoing flows according to a specific weight.
