Mitochondria produce energy and metabolic intermediates necessary for the survival of cells.They also play important roles in immunity.Emerging evidence has indicated that mitochondria can be involved in various disea...Mitochondria produce energy and metabolic intermediates necessary for the survival of cells.They also play important roles in immunity.Emerging evidence has indicated that mitochondria can be involved in various diseases by triggering immune responses(Baum,1995;Berg and Klein,1986).Mitochondrial antigens(MtAgs)refer to any substances derived from mitochondria that can be recognized by the adaptive immune system and cause immune responses.Mitochondria release danger-associated molecular patterns upon cellular stress or damage and act as signaling hubs in innate immunity,which is another big topic that we will not discuss here.In this review,we describe the varieties of MtAgs,their presentation and involvements in diseases,suggesting a potential immunopathogenic mechanism(Figure 1).展开更多
基金supported by the National Key Research and Development Program of China (2023YFC3404500, 2021YFA1300502, 2021YFA1302000)the National Natural Science Foundation of China (92057210, 82125017, 91942309, 82173064, 81971481)+2 种基金the Science and Technology Program of Guang-zhou (202103000070, 202201020467, 202201020479)the New Cornerstone Science Foundation through the New Cornerstone Investigator Programthe XPLORER PRIZE
文摘Mitochondria produce energy and metabolic intermediates necessary for the survival of cells.They also play important roles in immunity.Emerging evidence has indicated that mitochondria can be involved in various diseases by triggering immune responses(Baum,1995;Berg and Klein,1986).Mitochondrial antigens(MtAgs)refer to any substances derived from mitochondria that can be recognized by the adaptive immune system and cause immune responses.Mitochondria release danger-associated molecular patterns upon cellular stress or damage and act as signaling hubs in innate immunity,which is another big topic that we will not discuss here.In this review,we describe the varieties of MtAgs,their presentation and involvements in diseases,suggesting a potential immunopathogenic mechanism(Figure 1).
