Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper th...Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper the clinical application.Numerous evidences support macrophages as the key immune cells during bone remodeling.Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2;R26GFP lineage tracing system.Fluorescence staining,flow cytometry analysis,and western blot determined the significantly enhanced expression of binding immunoglobulin protein(BiP)and emphasized the activation of sensor activating transcription factor 6(ATF6)in macrophages.Then,we verified that macrophage specific ATF6 deletion(ATF6f/f;CX3CR1CreERT2 mice)decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy.In contrast,macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement.In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6.At the mechanism level,RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfαpromotor and augmenting its transcription.Additionally,molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element(ERSE).Taken together,ATF6 may aggravate orthodontic bone remodeling by promoting Tnfαtranscription in macrophages,suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.展开更多
The approximately 3000 km long Tan-Lu fault zone(TLFZ)in East Asia is the longest continental strike-slip fault zone in the world and exemplifies how such a fault zone forms and propagates on a continental scale.Struc...The approximately 3000 km long Tan-Lu fault zone(TLFZ)in East Asia is the longest continental strike-slip fault zone in the world and exemplifies how such a fault zone forms and propagates on a continental scale.Structural and geochronological data from the TLFZ and surrounding regions indicate that the fault zone originated as NE/SW-striking sinistral ductile shear zones along an oblique continental convergence margin during the Triassic indentation collision between the North China Craton and the Yangtze Block.The Triassic fault zone,with a total length of about 720 km between the Dabie and Sulu orogens,exhibited an apparent sinistral offset of approximately 300 km along the TLFZ.The second stage of sinistral movement occurred in the earliest Late Jurassic,reactivating the pre-existing southern segment and propagating northwards to the southern coastline of present-day Bohai Bay,as well as forming a significant portion of the Dunhua-Mishan fault zone.The third stage of sinistral movement,in the earliest Early Cretaceous,was the most intense strike-slip movement of the Mesozoic,leading to the complete linkage of the TLFZ.This stage included further northward propagation of the southern-middle segment,both southward and northward propagation of the Dunhua-Mishan fault zone,as well as the formation of the entire Yilan-Yitong fault zone.The fourth stage,in the earliest Late Cretaceous,involved the reactivation of the entire TLFZ.Following its Triassic origin due to the indentation collision,the subduction of the Paleo-Pacific Plate and the subduction and closure of the Mongol-Okhotsk Ocean were responsible for the multi-stage sinistral movements from the Late Jurassic to the Cretaceous.The evolution of the TLFZ demonstrates that a continental-scale strike-slip fault zone(>1000 km long)forms through multiple stages of propagation and linkage in dynamic settings of plate convergence.展开更多
Flexible circuit switches have been widely used in electronic devices due to their outstanding flexibility and operability.In order to expand the types of flexible circuit switch materials,we develop a unique composit...Flexible circuit switches have been widely used in electronic devices due to their outstanding flexibility and operability.In order to expand the types of flexible circuit switch materials,we develop a unique composite material,which integrates a photoresponsive flexible substrate derived from a photoreactive coordination polymer(CP)with an elastic conductive adhesive tape(CAT)in this work.The photoreactive CP{[Cd(2,6-bpvn)(3,5-DBB)_(2)]·DMF}_(n)(1)is prepared through solvothermal reaction of Cd(NO_(3))_(2)·4H_(2)O with 2,6-bis((E)-2-(pyridin-4-yl)vinyl)naphthalene(2,6-bpvn)and 3,5-dibromobenzoic acid(3,5-HDBB).Upon irradiation with UV light,crystals of 1 can undergo[2+2]photocycloaddition reaction and exhibit photomechanical movements.The crystalline powder of 1 can be uniformly distributed in polyvinyl alcohol(PVA)to generate the composite film 1-PVA.After pasting a piece of CAT on the surface of a 1-PVA film,a conductive two-layer film of 1-PVA/CAT can be fabricated.This film bends rapidly upon UV light exposure,connecting the circuit and causing the bulb to light up.When the light source is removed,it reverts to its initial state and the circuit is disconnected and the bulb is extinguished.This process can be cycled at least 100 times,achieving precise turn-on and turn-off performances of the photocontrollable circuit switch.展开更多
1.Introduction Adherence to 24-hour movement guidelines—which encompass regular physical activity,adequate sleep,and limited sedentary time1—significantly influences long-term health outcomes during adolescence and ...1.Introduction Adherence to 24-hour movement guidelines—which encompass regular physical activity,adequate sleep,and limited sedentary time1—significantly influences long-term health outcomes during adolescence and contributes holistically to overall health.2 However,its prospective relationship with midlife mortality remains unknown to date.Our aim was to determine the association between adherence to 24-hour movement guidelines during adolescence and premature mortality 26-27 years later.This aim was based on existing evidence3 suggesting a potential link between meeting these guidelines and reduced mortality risk among adults in an 11-year follow-up.展开更多
The successful penetration of government,corporate,and organizational IT systems by state and non-state actors deploying APT vectors continues at an alarming pace.Advanced Persistent Threat(APT)attacks continue to pos...The successful penetration of government,corporate,and organizational IT systems by state and non-state actors deploying APT vectors continues at an alarming pace.Advanced Persistent Threat(APT)attacks continue to pose significant challenges for organizations despite technological advancements in artificial intelligence(AI)-based defense mechanisms.While AI has enhanced organizational capabilities for deterrence,detection,and mitigation of APTs,the global escalation in reported incidents,particularly those successfully penetrating critical government infrastructure has heightened concerns among information technology(IT)security administrators and decision-makers.Literature review has identified the stealthy lateral movement(LM)of malware within the initially infected local area network(LAN)as a significant concern.However,current literature has yet to propose a viable approach for resource-efficient,real-time detection of APT malware lateral movement within the initially compromised LAN following perimeter breach.Researchers have suggested the nature of the dataset,optimal feature selection,and the choice of machine learning(ML)techniques as critical factors for detection.Hence,the objective of the research described here was to successfully demonstrate a simplified lightweight ML method for detecting the LM of APT vectors.While the nearest detection rate achieved in the LM domain within LAN was 99.89%,as reported in relevant studies,our approach surpassed it,with a detection rate of 99.95%for the modified random forest(RF)classifier for dataset 1.Additionally,our approach achieved a perfect 100%detection rate for the decision tree(DT)and RF classifiers with dataset 2,a milestone not previously reached in studies within this domain involving two distinct datasets.Using the ML life cycle methodology,we deployed K-nearest neighbor(KNN),support vector machine(SVM),DT,and RF on three relevant datasets to detect the LM of APTs at the affected LAN prior to data exfiltration/destruction.Feature engineering presented four critical APT LM intrusion detection(ID)indicators(features)across the three datasets,namely,the source port number,the destination port number,the packets,and the bytes.This study demonstrates the effectiveness of lightweight ML classifiers in detecting APT lateral movement after network perimeter breach.It contributes to the field by proposing a non-intrusive network detection method capable of identifying APT malware before data exfiltration,thus providing an additional layer of organizational defense.展开更多
A novel block–particle discrete-element simulation method that matches the double medium of overlying rock(OLR)and loose layer(LSL)in coal mining is developed in this study.This method achieves the collaborative fail...A novel block–particle discrete-element simulation method that matches the double medium of overlying rock(OLR)and loose layer(LSL)in coal mining is developed in this study.This method achieves the collaborative failure characteristics of mining damage under the conduction of double media between the OLR and LSL by combining the self-weight stress loading of the LSL and the breakage morphology of the bedrock top.Based on this,the conduction law of high-strength mining damage in the double medium in a western mining area is simulated and analyzed.The combining effect of the OLR breakage morphology and LSL characteristics on the surface-subsidence characteristics is analyzed and verified based on on-site measurements.The results indicate that the OLR is guided by the“double-control layer and thick-soft rock buffer layer”and shows“grouping subsidence”,whereas the surface forms collaborative subsidence with the thick-soft rock buffer layer.In the ultra-full mining stage,the surface presents an“asymmetric inverted trapezoidal”subsidence trough shape.The simulation results agree well the on-site measurements in terms of the surface-subsidence and bedrock-subsidence coefficients.The proposed simulation method provides a scientific approach for investigating the micro-conduction mechanism of mining damage under the effect of high-strength mining in western mining areas.It will benefit future investigations pertaining to the characteristics of OLR breakage and surface subsidence under conditions such as LSL thickness and proportion.展开更多
Limb movement disorder after stroke is one of the main causes of disability,seriously affecting patients’quality of life.Although modern medical treatment can alleviate some symptoms,it has limitations.Traditional Ch...Limb movement disorder after stroke is one of the main causes of disability,seriously affecting patients’quality of life.Although modern medical treatment can alleviate some symptoms,it has limitations.Traditional Chinese medicine,with an overall perspective and syndrome differentiation and treatment as its core,intervenes in the disease through various therapies,such as acupuncture,Chinese herbal medicine,Tuina massage,and traditional exercise,demonstrating unique advantages.This article reviews the understanding of the etiology and pathogenesis of limb movement disorders after stroke in traditional Chinese medicine,systematically summarizes the clinical application and research progress of main treatment methods such as acupuncture,Chinese herbal medicine,and Tuina massage,analyzes the problems existing in current research,and looks forward to future development directions,aiming to provide references for clinical treatment.展开更多
The deep seabed is known for its abundant reserves of various mineral resources.Notably,the Clarion Clipperton(C-C)mining area in the northeast Pacific Ocean,where China holds exploration rights,is particularly rich i...The deep seabed is known for its abundant reserves of various mineral resources.Notably,the Clarion Clipperton(C-C)mining area in the northeast Pacific Ocean,where China holds exploration rights,is particularly rich in deep-sea polymetallic nodules.These nodules,which are nodular and unevenly distributed in seafloor sediments,have significant industrial exploitation value.Over the decades,the deep-sea mining industry has increasingly adopted systems that combine rigid and flexible risers supported by large surface mining vessels.However,current systems face economic and structural stability challenges,hindering the development of deep-sea mining technology.This paper proposes a new structural design for a deep-sea mining system based on flexible risers,validated through numerical simulations and experimental research.The system composition,function and operational characteristics are comprehensively introduced.Detailed calculations determine the production capacity of the deep-sea mining system and the dimensions of the seabed mining subsystem.Finite element numerical simulations analyze the morphological changes of flexible risers and the stress conditions at key connection points under different ocean current incident angles.Experimental research verifies the feasibility of collaborative movement between two tethered underwater devices.The proposed deep-sea mining system,utilizing flexible risers,significantly advances the establishment of a commercial deep-sea mining system.The production calculations and parameter determinations provide essential references for the system’s future detailed design.Furthermore,the finite element simulation model established in this paper provides a research basis,and the method established in this paper offers a foundation for subsequent research under more complex ocean conditions.The control strategy for the collaborative movement between two tethered underwater devices provides an effective solution for deep-sea mining control systems.展开更多
Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects ...Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects of tTIS on the superior colliculus(SC),a region involved in eye movement control,in mice.Computational modeling revealed that tTIS delivers more focused stimulation to the SC than traditional transcranial alternating current stimulation.In vivo experiments,including Ca^(2+)signal recordings and eye movement tracking,showed that tTIS effectively modulates SC neural activity and induces eye movements.A significant correlation was found between stimulation frequency and saccade frequency,suggesting direct tTIS-induced modulation of SC activity.These results demonstrate the precision of tTIS in targeting deep brain regions and regulating eye movements,highlighting its potential for neuroscientific research and therapeutic applications.展开更多
The historical movements of relative sea level(RSL)reflect the geomorphological dynamics around coastal regions in the past,and reconstructing the RSL curve contributes to the prediction of future RSL movements.On the...The historical movements of relative sea level(RSL)reflect the geomorphological dynamics around coastal regions in the past,and reconstructing the RSL curve contributes to the prediction of future RSL movements.On the basis of the sediment sequence and optical stimulated luminescence(OSL)dating data of three boreholes in the Yellow River Delta(YRD),the positions of paleo-coastlines and the movements of RSL in the last 2000 years were reconstructed.The main results are as follows:1)the YRD coast transformed from a tide-dominated silty coast to a wave-dominated sandy coast and back to a tide-dominated silty coast in the last 2000 years.2)The sand layers consisting of shell fragments indicated the locations of the coastline in 1855 AD,893 AD,and 40 BC,and their top elevations were close to the mean high water level in the corresponding years.3)The mean sea level elevation in 79 BC,1019 AD,and 1800 AD relative to the modern sea level was -4.52,-4.52,and-2.92 m,respectively.4)The RSL was almost stagnant during 79 BC-1019 AD,rose slowly during 1019-1800 AD due to the reverse change of global climate from the Little Ice Age to the Medieval Warm Period,and rose significantly after 1800 AD due to the warm period.5)The movement of RSL controlled the surface slope of YRD,which was a slope of approximately 0.022‰ at 893 AD,an inverted slope of 0.144‰ at 1855 AD,and a slope of 0.075‰ recently.These findings indicate that the modern YRD is far from being abandoned in the future,providing a historical geomorphological basis for the management of the Yellow River Estuary.展开更多
Lateral movement represents the most covert and critical phase of Advanced Persistent Threats(APTs),and its detection still faces two primary challenges:sample scarcity and“cold start”of new entities.To address thes...Lateral movement represents the most covert and critical phase of Advanced Persistent Threats(APTs),and its detection still faces two primary challenges:sample scarcity and“cold start”of new entities.To address these challenges,we propose an Uncertainty-Driven Graph Embedding-Enhanced Lateral Movement Detection framework(UGEA-LMD).First,the framework employs event-level incremental encoding on a continuous-time graph to capture fine-grained behavioral evolution,enabling newly appearing nodes to retain temporal contextual awareness even in the absence of historical interactions and thereby fundamentally mitigating the cold-start problem.Second,in the embedding space,we model the dependency structure among feature dimensions using a Gaussian copula to quantify the uncertainty distribution,and generate augmented samples with consistent structural and semantic properties through adaptive sampling,thus expanding the representation space of sparse samples and enhancing the model’s generalization under sparse sample conditions.Unlike static graph methods that cannot model temporal dependencies or data augmentation techniques that depend on predefined structures,UGEA-LMD offers both superior temporaldynamic modeling and structural generalization.Experimental results on the large-scale LANL log dataset demonstrate that,under the transductive setting,UGEA-LMD achieves an AUC of 0.9254;even when 10%of nodes or edges are withheld during training,UGEA-LMD significantly outperforms baseline methods on metrics such as recall and AUC,confirming its robustness and generalization capability in sparse-sample and cold-start scenarios.展开更多
Background:The Canadian 24-h movement guidelines(24-HMG)emphasize the holistic consideration of physical activity(PA),sedentary behavior,and sleep in shaping health outcomes.This study aimed to examine the association...Background:The Canadian 24-h movement guidelines(24-HMG)emphasize the holistic consideration of physical activity(PA),sedentary behavior,and sleep in shaping health outcomes.This study aimed to examine the associations between meeting 24-HMG and emotion regulation-related indicators among children and adolescents.Methods:A total of 534 Chinese children and adolescents aged 12.94±1.10 years(49.81%males)participated in this study and completed self-report measures assessing 24-h movement behaviors,emotion regulation strategies,emotion regulation flexibility,and regulatory emotional self-efficacy.Results:Only 7.12% of theparticipants adhered to two or all three guidelines.The number of guidelines met was positively associated with the use of emotion regulation strategies,emotion regulation flexibility,and regulatory emotional self-efficacy.Compared with meeting none of the guidelines,participants whomet one ormore guidelines reported significantly better performance in these outcomes.Conclusion:Meeting 24-HMG was associated with superior emotion regulation in children and adolescents.The importance of engaging in regular PA,limiting recreational screen time,and getting enough sleep should be highlighted for fostering emotion regulation in this demographic.展开更多
Background:Meeting the 24-Hour Movement Guidelines(physical activity,screen time,and sleep duration) has been associated with positive health indicators.However,there are no previous meta-analyses that have examined t...Background:Meeting the 24-Hour Movement Guidelines(physical activity,screen time,and sleep duration) has been associated with positive health indicators.However,there are no previous meta-analyses that have examined the overall adherence to the 24-Hour Movement Guidelines from pre-school to adolescence across the world.Therefore,the main purpose of this systematic review and meta-analysis was to examine the overall(non)adherence to the 24-Hour Movement Guidelines among preschoolers,children,and adolescents worldwide.Methods:Four electronic databases(MEDLINE,Scopus,Web of Science,and Cochrane Database of Systematic Reviews) were searched for quantitative studies published in Spanish and English between January 2016 and May 2021.Studies that were conducted with apparently healthy participants and reported the overall(non)adherence to the 24-Hour Movement Guidelines in preschoolers and/or children and/or adolescents were included.Results:Sixty-three studies comprising 387,437 individuals(51% girls) aged 3-18 years from 23 countries were included.Overall,7.12%(95%confidence interval(95%CI):6.45%-7.78%) of youth met all three 24-Hour Movement Guidelines,and 19.21%(95%CI:16.73%-21.69%)met none of the 3 recommendations.Concerning sex,adherence to all recommendations was significantly lower in girls(3.75%,95%CI:3.23%-4.27%) than in boys(6.89%,95%CI:5.89%-7.89%)(p <0.001).However,there were no sex differences regarding adherence to any of the 3 individual recommendations(girls,15.66%,95%CI:8.40%-22.92%;boys,12.95%,95%CI:6.57%-19.33%).In terms of age group,adherence to the 3 recommendations was 11.26%(95%CI:8.68%-13.84%),10.31%(95%CI:7.49%-13.12%),and 2.68%(95%CI:1.78%-3.58%) in preschoolers,children,and adolescents,respectively.Conversely,8.81%(95%CI:5.97%-11.64%) of preschoolers,15.57%(95%CI:11.60%-19.54%) of children,and 28.59%(95%CI:22.42%-34.75%) of adolescents did not meet any of the recommendations.South America was the region with the lowest adherence(all:2.93%;none:31.72%).Overall adherence to the 24-Hour Movement Guidelines was positively related to country Human Development Index(β=-0.37,95%CI:-0.65 to-0.09;p=0.010).Conclusion:Most young people fail to meet the three 24-Hour Movement Guidelines,particularly adolescents,girls,and those who are from countries with a lower Human Development Index.Moreover,1 in 5 young people did not meet any of these recommendations.Therefore,these results highlight the need to develop age-and sex-specific strategies to promote these movement behaviors from the early stages of life.展开更多
The analysis of Earth’s crust movement vertical velocities was made both for separate regions, and averaged on regions. As input data coordinates and velocities of earth crust points, obtained in International Coordi...The analysis of Earth’s crust movement vertical velocities was made both for separate regions, and averaged on regions. As input data coordinates and velocities of earth crust points, obtained in International Coordinate Systems ITRF2000, ITRF2005,ITRF2008 on the base of processing radio interferometric(VLBI), laser(SLR), Doppler(DORIS) and GPS observations was used. For the purpose of global analysis all input velocity values were averaged in the x trapezoids. For filling trapezoids the spherical function expansion to N=36 was made. Expansion harmonic coefficients allowed determine the global characteristics of earth crust movements both for all Earth, and for separate hemispheres, polar and equatorial regions, continents and oceans. It appears, that polar regions were risen, and equatorial ones were lowered, that can indicate the modern Earth oblateness reduction. The constructed maps of vertical velocities were compared with obtained by us map of earth crust strain distribution. It is appeared, that regions of modern earth surface rising(Fennoscandia, Canada, Antarctica) coincide with regions of vertical extension strain, and the lowering regions-with compression regions. Simultaneously with the determination of harmonious coefficients the mean-square error of approximation for expansion of power n=1 N and power dispersion were determined. Whereas the results converge badly and dispersion increased with the n grows, hence we can concludes, that vertical movements do not characterized global earth crust movement and denotes the unrelated character of these movement. Seemingly, the main cause of such movement origin is the local seismic events(earthquake, volcanic eruption and so on). It confirms by our conclusions about correspondence of vertical strain maximal gradient(and therefore vertical velocities) map of the earthquake distribution. In work the detailed analysis of obtained results for separate Earth’s regions was made.展开更多
The three dimensional variable cross-section roll forming is a kind of new metal forming technol- ogy which combines large forming force, multi-axis linkage movement and space synergic movement, and the sequential syn...The three dimensional variable cross-section roll forming is a kind of new metal forming technol- ogy which combines large forming force, multi-axis linkage movement and space synergic movement, and the sequential synergic movement of the ganged roller group is used to complete the metal sheet forming according to the shape of the complicated and variable forming part data. The control system should meet the demands of quick response to the test requirements of the product part. A new kind of real time data driving multi-axis linkage and synergic movement control strategy of 3D roll forming is put forward in the paper. In the new control strategy, the forming data are automatically generated according to the shape of the parts, and the multi-axis linkage movement together with cooperative motion among the six stands of the 3D roll forming machine is driven by the real-time information, and the control nodes are also driven by the forming data. The new control strategy is applied to a 48 axis 3D roll forming machine developed by our research center, and the control servo period is less than 10ms. A forming experiment of variable cross section part is carried out, and the forming preci- sion is better than ＋ 0.5mm by the control strategy. The result of the experiment proves that the control strategy has significant potentiality for the development of 3D roll forming production line with large scale, multi-axis ganged and svner^ic movement展开更多
The novel eye-based human-computer interaction(HCI) system aims to provide people, especially, disabled persons,a new way of communication with surroundings. It adopts a series of continual eye movements as input to p...The novel eye-based human-computer interaction(HCI) system aims to provide people, especially, disabled persons,a new way of communication with surroundings. It adopts a series of continual eye movements as input to perform simple control activities. Identification of eye movements is the crucial technology in these eye-based HCI systems. At present, researches on eye movement identification mainly focus on frontal face images. In fact, acquisition of non-frontal face images is more reasonable in real applications. In this paper, we discuss the identification process of eye movements from non-frontal face images. Firstly, the original head-shoulder images of 0?–±60?azimuths are sampled without any auxiliary light source. Secondly, the non-frontal face region is detected by using the Adaboost cascade classifiers. After that, we roughly extract eye windows by the integral projection function.Then, we propose a new method to calculate the x- y coordinates of the pupil center point by searching the minimal intensity value in the eye windows. According to the trajectory of the pupil center points, different eye movements(eye moving left, right, up or down)are successfully identified. A set of experiments is presented.展开更多
The accuracy and repeatability of the laser interferometer measurement system （LIMS） are often limited by the mirror surface error that comes from the mirror surface shape and distortion. This paper describes a new ...The accuracy and repeatability of the laser interferometer measurement system （LIMS） are often limited by the mirror surface error that comes from the mirror surface shape and distortion. This paper describes a new method to calibrate mirror map on ultraprecise movement stage （UPMS） with nanopositioning and to make a real-time compensation for the mirror surface error by using mirror map data tables with the software algorithm. Based on the mirror map test model, the factors affecting mirror map are analyzed through geometric method on the UPMS with six digrees of freedom. Dam processing methods including spline interpolation and spline offsets are used to process the raw sampling data to build mirror map tables. The linear interpolation as compensation method to make a real-time correction on the stage mirror unflatness is adopted and the correction formulas are illuminated. In this way, the measurement accuracy of the system is obviously improved from 40 nm to 5 nm.展开更多
Vehicle turning movement data from signalized intersections is utilized for numerous applications in the field of transportation. Such applications include real-time adaptive signal control, dynamic traffic assignment...Vehicle turning movement data from signalized intersections is utilized for numerous applications in the field of transportation. Such applications include real-time adaptive signal control, dynamic traffic assignment, and traffic demand estimation. However, it is very time consuming and costly to obtain vehicle turning movement information manually. Previous efforts to simplify this process were focused on solving the problem using an O-D matrix, but this method proved to be inaccurate and unreliable with the existing data acquisition system. Another study involved the identification of vehicle turning movements from the detector information, but the presence of shared lanes led to uncertainties in vehicle matching, thus limiting application of the method only to intersections without shared lanes. In light of those unsuccessful attempts, this paper develops and tests a system called the Automatic Turning Movement Identification System (ATMIS), which estimates vehicle turning movements at a signalized intersection in real time, regardless of its geometry. The results from lab experiments as well as a field test show that the algorithm is very promising and may potentially be expanded for field applications.展开更多
Pyroptosis,an inflammatory caspase-dependent programmed cell death,plays a vital role in maintaining tissue homeostasis and activating inflammatory responses.Orthodontic tooth movement(OTM)is an aseptic force-induced ...Pyroptosis,an inflammatory caspase-dependent programmed cell death,plays a vital role in maintaining tissue homeostasis and activating inflammatory responses.Orthodontic tooth movement(OTM)is an aseptic force-induced inflammatory bone remodeling process mediated by the activation of periodontal ligament(PDL)progenitor cells.However,whether and how force induces PDL progenitor cell pyroptosis,thereby influencing OTM and alveolar bone remodeling remains unknown.In this study,we found that mechanical force induced the expression of pyroptosis-related markers in rat OTM and alveolar bone remodeling process.Blocking or enhancing pyroptosis level could suppress or promote OTM and alveolar bone remodeling respectively.Using Caspase-1^(−/−)mice,we further demonstrated that the functional role of the force-induced pyroptosis in PDL progenitor cells depended on Caspase-1.Moreover,mechanical force could also induce pyroptosis in human ex-vivo force-treated PDL progenitor cells and in compressive force-loaded PDL progenitor cells in vitro,which influenced osteoclastogenesis.Mechanistically,transient receptor potential subfamily V member 4 signaling was involved in force-induced Caspase-1-dependent pyroptosis in PDL progenitor cells.Overall,this study suggested a novel mechanism contributing to the modulation of osteoclastogenesis and alveolar bone remodeling under mechanical stimuli,indicating a promising approach to accelerate OTM by targeting Caspase-1.展开更多
基金supported by the National Natural Science Foundation of China(82071143,82371000,82270361)Key Research and Development Program of Jiangsu Province(BE2022795)+2 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_1801)the Jiangsu Province Capability Improvement Project through the Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(YJXYYJSDW4)Jiangsu Provincial Medical Innovation Center(CXZX202227).
文摘Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper the clinical application.Numerous evidences support macrophages as the key immune cells during bone remodeling.Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2;R26GFP lineage tracing system.Fluorescence staining,flow cytometry analysis,and western blot determined the significantly enhanced expression of binding immunoglobulin protein(BiP)and emphasized the activation of sensor activating transcription factor 6(ATF6)in macrophages.Then,we verified that macrophage specific ATF6 deletion(ATF6f/f;CX3CR1CreERT2 mice)decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy.In contrast,macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement.In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6.At the mechanism level,RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfαpromotor and augmenting its transcription.Additionally,molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element(ERSE).Taken together,ATF6 may aggravate orthodontic bone remodeling by promoting Tnfαtranscription in macrophages,suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.
基金funded by the Ministry of Science and Technology of the People's Republic of China(Grant 2024ZD1001301)the National Natural Science Foundation of China(Grants 42272241,42102254 and 41830213)the Fundamental Research Funds for the Central Universities(Grant JZ2023HGTB0238).
文摘The approximately 3000 km long Tan-Lu fault zone(TLFZ)in East Asia is the longest continental strike-slip fault zone in the world and exemplifies how such a fault zone forms and propagates on a continental scale.Structural and geochronological data from the TLFZ and surrounding regions indicate that the fault zone originated as NE/SW-striking sinistral ductile shear zones along an oblique continental convergence margin during the Triassic indentation collision between the North China Craton and the Yangtze Block.The Triassic fault zone,with a total length of about 720 km between the Dabie and Sulu orogens,exhibited an apparent sinistral offset of approximately 300 km along the TLFZ.The second stage of sinistral movement occurred in the earliest Late Jurassic,reactivating the pre-existing southern segment and propagating northwards to the southern coastline of present-day Bohai Bay,as well as forming a significant portion of the Dunhua-Mishan fault zone.The third stage of sinistral movement,in the earliest Early Cretaceous,was the most intense strike-slip movement of the Mesozoic,leading to the complete linkage of the TLFZ.This stage included further northward propagation of the southern-middle segment,both southward and northward propagation of the Dunhua-Mishan fault zone,as well as the formation of the entire Yilan-Yitong fault zone.The fourth stage,in the earliest Late Cretaceous,involved the reactivation of the entire TLFZ.Following its Triassic origin due to the indentation collision,the subduction of the Paleo-Pacific Plate and the subduction and closure of the Mongol-Okhotsk Ocean were responsible for the multi-stage sinistral movements from the Late Jurassic to the Cretaceous.The evolution of the TLFZ demonstrates that a continental-scale strike-slip fault zone(>1000 km long)forms through multiple stages of propagation and linkage in dynamic settings of plate convergence.
基金support from the National Natural Science Foundation of China(No.U24A20507,22271203)the State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences(No.2024KF005)Open Research Fund of State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering of Nanjing University and the Collaborative Innovation Centre of Suzhou Nano Science and Technology.
文摘Flexible circuit switches have been widely used in electronic devices due to their outstanding flexibility and operability.In order to expand the types of flexible circuit switch materials,we develop a unique composite material,which integrates a photoresponsive flexible substrate derived from a photoreactive coordination polymer(CP)with an elastic conductive adhesive tape(CAT)in this work.The photoreactive CP{[Cd(2,6-bpvn)(3,5-DBB)_(2)]·DMF}_(n)(1)is prepared through solvothermal reaction of Cd(NO_(3))_(2)·4H_(2)O with 2,6-bis((E)-2-(pyridin-4-yl)vinyl)naphthalene(2,6-bpvn)and 3,5-dibromobenzoic acid(3,5-HDBB).Upon irradiation with UV light,crystals of 1 can undergo[2+2]photocycloaddition reaction and exhibit photomechanical movements.The crystalline powder of 1 can be uniformly distributed in polyvinyl alcohol(PVA)to generate the composite film 1-PVA.After pasting a piece of CAT on the surface of a 1-PVA film,a conductive two-layer film of 1-PVA/CAT can be fabricated.This film bends rapidly upon UV light exposure,connecting the circuit and causing the bulb to light up.When the light source is removed,it reverts to its initial state and the circuit is disconnected and the bulb is extinguished.This process can be cycled at least 100 times,achieving precise turn-on and turn-off performances of the photocontrollable circuit switch.
文摘1.Introduction Adherence to 24-hour movement guidelines—which encompass regular physical activity,adequate sleep,and limited sedentary time1—significantly influences long-term health outcomes during adolescence and contributes holistically to overall health.2 However,its prospective relationship with midlife mortality remains unknown to date.Our aim was to determine the association between adherence to 24-hour movement guidelines during adolescence and premature mortality 26-27 years later.This aim was based on existing evidence3 suggesting a potential link between meeting these guidelines and reduced mortality risk among adults in an 11-year follow-up.
基金Rabdan Academy for funding the research presented in the paper.
文摘The successful penetration of government,corporate,and organizational IT systems by state and non-state actors deploying APT vectors continues at an alarming pace.Advanced Persistent Threat(APT)attacks continue to pose significant challenges for organizations despite technological advancements in artificial intelligence(AI)-based defense mechanisms.While AI has enhanced organizational capabilities for deterrence,detection,and mitigation of APTs,the global escalation in reported incidents,particularly those successfully penetrating critical government infrastructure has heightened concerns among information technology(IT)security administrators and decision-makers.Literature review has identified the stealthy lateral movement(LM)of malware within the initially infected local area network(LAN)as a significant concern.However,current literature has yet to propose a viable approach for resource-efficient,real-time detection of APT malware lateral movement within the initially compromised LAN following perimeter breach.Researchers have suggested the nature of the dataset,optimal feature selection,and the choice of machine learning(ML)techniques as critical factors for detection.Hence,the objective of the research described here was to successfully demonstrate a simplified lightweight ML method for detecting the LM of APT vectors.While the nearest detection rate achieved in the LM domain within LAN was 99.89%,as reported in relevant studies,our approach surpassed it,with a detection rate of 99.95%for the modified random forest(RF)classifier for dataset 1.Additionally,our approach achieved a perfect 100%detection rate for the decision tree(DT)and RF classifiers with dataset 2,a milestone not previously reached in studies within this domain involving two distinct datasets.Using the ML life cycle methodology,we deployed K-nearest neighbor(KNN),support vector machine(SVM),DT,and RF on three relevant datasets to detect the LM of APTs at the affected LAN prior to data exfiltration/destruction.Feature engineering presented four critical APT LM intrusion detection(ID)indicators(features)across the three datasets,namely,the source port number,the destination port number,the packets,and the bytes.This study demonstrates the effectiveness of lightweight ML classifiers in detecting APT lateral movement after network perimeter breach.It contributes to the field by proposing a non-intrusive network detection method capable of identifying APT malware before data exfiltration,thus providing an additional layer of organizational defense.
基金support for this work is provided by the National Key R&D Program of China(2023YFC3012101)the National Natural Science Foundation of China(52474161)the Fundamental Research Funds for the Central Universities(2024ZKPYNY01).
文摘A novel block–particle discrete-element simulation method that matches the double medium of overlying rock(OLR)and loose layer(LSL)in coal mining is developed in this study.This method achieves the collaborative failure characteristics of mining damage under the conduction of double media between the OLR and LSL by combining the self-weight stress loading of the LSL and the breakage morphology of the bedrock top.Based on this,the conduction law of high-strength mining damage in the double medium in a western mining area is simulated and analyzed.The combining effect of the OLR breakage morphology and LSL characteristics on the surface-subsidence characteristics is analyzed and verified based on on-site measurements.The results indicate that the OLR is guided by the“double-control layer and thick-soft rock buffer layer”and shows“grouping subsidence”,whereas the surface forms collaborative subsidence with the thick-soft rock buffer layer.In the ultra-full mining stage,the surface presents an“asymmetric inverted trapezoidal”subsidence trough shape.The simulation results agree well the on-site measurements in terms of the surface-subsidence and bedrock-subsidence coefficients.The proposed simulation method provides a scientific approach for investigating the micro-conduction mechanism of mining damage under the effect of high-strength mining in western mining areas.It will benefit future investigations pertaining to the characteristics of OLR breakage and surface subsidence under conditions such as LSL thickness and proportion.
文摘Limb movement disorder after stroke is one of the main causes of disability,seriously affecting patients’quality of life.Although modern medical treatment can alleviate some symptoms,it has limitations.Traditional Chinese medicine,with an overall perspective and syndrome differentiation and treatment as its core,intervenes in the disease through various therapies,such as acupuncture,Chinese herbal medicine,Tuina massage,and traditional exercise,demonstrating unique advantages.This article reviews the understanding of the etiology and pathogenesis of limb movement disorders after stroke in traditional Chinese medicine,systematically summarizes the clinical application and research progress of main treatment methods such as acupuncture,Chinese herbal medicine,and Tuina massage,analyzes the problems existing in current research,and looks forward to future development directions,aiming to provide references for clinical treatment.
基金Supported by Finance Science and Technology Project of Hainan Province under Grant No.ZDKJ2021027the National Natural Science Foundation of China under Grant No.52231012.
文摘The deep seabed is known for its abundant reserves of various mineral resources.Notably,the Clarion Clipperton(C-C)mining area in the northeast Pacific Ocean,where China holds exploration rights,is particularly rich in deep-sea polymetallic nodules.These nodules,which are nodular and unevenly distributed in seafloor sediments,have significant industrial exploitation value.Over the decades,the deep-sea mining industry has increasingly adopted systems that combine rigid and flexible risers supported by large surface mining vessels.However,current systems face economic and structural stability challenges,hindering the development of deep-sea mining technology.This paper proposes a new structural design for a deep-sea mining system based on flexible risers,validated through numerical simulations and experimental research.The system composition,function and operational characteristics are comprehensively introduced.Detailed calculations determine the production capacity of the deep-sea mining system and the dimensions of the seabed mining subsystem.Finite element numerical simulations analyze the morphological changes of flexible risers and the stress conditions at key connection points under different ocean current incident angles.Experimental research verifies the feasibility of collaborative movement between two tethered underwater devices.The proposed deep-sea mining system,utilizing flexible risers,significantly advances the establishment of a commercial deep-sea mining system.The production calculations and parameter determinations provide essential references for the system’s future detailed design.Furthermore,the finite element simulation model established in this paper provides a research basis,and the method established in this paper offers a foundation for subsequent research under more complex ocean conditions.The control strategy for the collaborative movement between two tethered underwater devices provides an effective solution for deep-sea mining control systems.
基金supported by the National Natural Science Foundation of China(T2394533,32222036,82030038,and 62472206)the National Key Research and Development Program of China(2018YFA0701400)the Shenzhen Science and Technology Innovation Committee(2022410129,KJZD20230923115221044,and KCXFZ20201221173400001).
文摘Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects of tTIS on the superior colliculus(SC),a region involved in eye movement control,in mice.Computational modeling revealed that tTIS delivers more focused stimulation to the SC than traditional transcranial alternating current stimulation.In vivo experiments,including Ca^(2+)signal recordings and eye movement tracking,showed that tTIS effectively modulates SC neural activity and induces eye movements.A significant correlation was found between stimulation frequency and saccade frequency,suggesting direct tTIS-induced modulation of SC activity.These results demonstrate the precision of tTIS in targeting deep brain regions and regulating eye movements,highlighting its potential for neuroscientific research and therapeutic applications.
基金supported financially by the National Natural Science Foundation of China(Nos.42330406 and 42476163)。
文摘The historical movements of relative sea level(RSL)reflect the geomorphological dynamics around coastal regions in the past,and reconstructing the RSL curve contributes to the prediction of future RSL movements.On the basis of the sediment sequence and optical stimulated luminescence(OSL)dating data of three boreholes in the Yellow River Delta(YRD),the positions of paleo-coastlines and the movements of RSL in the last 2000 years were reconstructed.The main results are as follows:1)the YRD coast transformed from a tide-dominated silty coast to a wave-dominated sandy coast and back to a tide-dominated silty coast in the last 2000 years.2)The sand layers consisting of shell fragments indicated the locations of the coastline in 1855 AD,893 AD,and 40 BC,and their top elevations were close to the mean high water level in the corresponding years.3)The mean sea level elevation in 79 BC,1019 AD,and 1800 AD relative to the modern sea level was -4.52,-4.52,and-2.92 m,respectively.4)The RSL was almost stagnant during 79 BC-1019 AD,rose slowly during 1019-1800 AD due to the reverse change of global climate from the Little Ice Age to the Medieval Warm Period,and rose significantly after 1800 AD due to the warm period.5)The movement of RSL controlled the surface slope of YRD,which was a slope of approximately 0.022‰ at 893 AD,an inverted slope of 0.144‰ at 1855 AD,and a slope of 0.075‰ recently.These findings indicate that the modern YRD is far from being abandoned in the future,providing a historical geomorphological basis for the management of the Yellow River Estuary.
基金supported by the Zhongyuan University of Technology Discipline Backbone Teacher Support Program Project(No.GG202417)the Key Research and Development Program of Henan under Grant 251111212000.
文摘Lateral movement represents the most covert and critical phase of Advanced Persistent Threats(APTs),and its detection still faces two primary challenges:sample scarcity and“cold start”of new entities.To address these challenges,we propose an Uncertainty-Driven Graph Embedding-Enhanced Lateral Movement Detection framework(UGEA-LMD).First,the framework employs event-level incremental encoding on a continuous-time graph to capture fine-grained behavioral evolution,enabling newly appearing nodes to retain temporal contextual awareness even in the absence of historical interactions and thereby fundamentally mitigating the cold-start problem.Second,in the embedding space,we model the dependency structure among feature dimensions using a Gaussian copula to quantify the uncertainty distribution,and generate augmented samples with consistent structural and semantic properties through adaptive sampling,thus expanding the representation space of sparse samples and enhancing the model’s generalization under sparse sample conditions.Unlike static graph methods that cannot model temporal dependencies or data augmentation techniques that depend on predefined structures,UGEA-LMD offers both superior temporaldynamic modeling and structural generalization.Experimental results on the large-scale LANL log dataset demonstrate that,under the transductive setting,UGEA-LMD achieves an AUC of 0.9254;even when 10%of nodes or edges are withheld during training,UGEA-LMD significantly outperforms baseline methods on metrics such as recall and AUC,confirming its robustness and generalization capability in sparse-sample and cold-start scenarios.
基金supported by Zhejiang Provincial Social Science Funding(22NDJC050YB).
文摘Background:The Canadian 24-h movement guidelines(24-HMG)emphasize the holistic consideration of physical activity(PA),sedentary behavior,and sleep in shaping health outcomes.This study aimed to examine the associations between meeting 24-HMG and emotion regulation-related indicators among children and adolescents.Methods:A total of 534 Chinese children and adolescents aged 12.94±1.10 years(49.81%males)participated in this study and completed self-report measures assessing 24-h movement behaviors,emotion regulation strategies,emotion regulation flexibility,and regulatory emotional self-efficacy.Results:Only 7.12% of theparticipants adhered to two or all three guidelines.The number of guidelines met was positively associated with the use of emotion regulation strategies,emotion regulation flexibility,and regulatory emotional self-efficacy.Compared with meeting none of the guidelines,participants whomet one ormore guidelines reported significantly better performance in these outcomes.Conclusion:Meeting 24-HMG was associated with superior emotion regulation in children and adolescents.The importance of engaging in regular PA,limiting recreational screen time,and getting enough sleep should be highlighted for fostering emotion regulation in this demographic.
基金the financial support of the Ministry of Economy and Infrastructures and European Communitysupported by the Ministry of Economy and Infrastructures of Extremadura (PD 18015)funded by FEDER,FSE and Govern of Extremadura,grant numbers GR18102 and TA18027.
文摘Background:Meeting the 24-Hour Movement Guidelines(physical activity,screen time,and sleep duration) has been associated with positive health indicators.However,there are no previous meta-analyses that have examined the overall adherence to the 24-Hour Movement Guidelines from pre-school to adolescence across the world.Therefore,the main purpose of this systematic review and meta-analysis was to examine the overall(non)adherence to the 24-Hour Movement Guidelines among preschoolers,children,and adolescents worldwide.Methods:Four electronic databases(MEDLINE,Scopus,Web of Science,and Cochrane Database of Systematic Reviews) were searched for quantitative studies published in Spanish and English between January 2016 and May 2021.Studies that were conducted with apparently healthy participants and reported the overall(non)adherence to the 24-Hour Movement Guidelines in preschoolers and/or children and/or adolescents were included.Results:Sixty-three studies comprising 387,437 individuals(51% girls) aged 3-18 years from 23 countries were included.Overall,7.12%(95%confidence interval(95%CI):6.45%-7.78%) of youth met all three 24-Hour Movement Guidelines,and 19.21%(95%CI:16.73%-21.69%)met none of the 3 recommendations.Concerning sex,adherence to all recommendations was significantly lower in girls(3.75%,95%CI:3.23%-4.27%) than in boys(6.89%,95%CI:5.89%-7.89%)(p <0.001).However,there were no sex differences regarding adherence to any of the 3 individual recommendations(girls,15.66%,95%CI:8.40%-22.92%;boys,12.95%,95%CI:6.57%-19.33%).In terms of age group,adherence to the 3 recommendations was 11.26%(95%CI:8.68%-13.84%),10.31%(95%CI:7.49%-13.12%),and 2.68%(95%CI:1.78%-3.58%) in preschoolers,children,and adolescents,respectively.Conversely,8.81%(95%CI:5.97%-11.64%) of preschoolers,15.57%(95%CI:11.60%-19.54%) of children,and 28.59%(95%CI:22.42%-34.75%) of adolescents did not meet any of the recommendations.South America was the region with the lowest adherence(all:2.93%;none:31.72%).Overall adherence to the 24-Hour Movement Guidelines was positively related to country Human Development Index(β=-0.37,95%CI:-0.65 to-0.09;p=0.010).Conclusion:Most young people fail to meet the three 24-Hour Movement Guidelines,particularly adolescents,girls,and those who are from countries with a lower Human Development Index.Moreover,1 in 5 young people did not meet any of these recommendations.Therefore,these results highlight the need to develop age-and sex-specific strategies to promote these movement behaviors from the early stages of life.
文摘The analysis of Earth’s crust movement vertical velocities was made both for separate regions, and averaged on regions. As input data coordinates and velocities of earth crust points, obtained in International Coordinate Systems ITRF2000, ITRF2005,ITRF2008 on the base of processing radio interferometric(VLBI), laser(SLR), Doppler(DORIS) and GPS observations was used. For the purpose of global analysis all input velocity values were averaged in the x trapezoids. For filling trapezoids the spherical function expansion to N=36 was made. Expansion harmonic coefficients allowed determine the global characteristics of earth crust movements both for all Earth, and for separate hemispheres, polar and equatorial regions, continents and oceans. It appears, that polar regions were risen, and equatorial ones were lowered, that can indicate the modern Earth oblateness reduction. The constructed maps of vertical velocities were compared with obtained by us map of earth crust strain distribution. It is appeared, that regions of modern earth surface rising(Fennoscandia, Canada, Antarctica) coincide with regions of vertical extension strain, and the lowering regions-with compression regions. Simultaneously with the determination of harmonious coefficients the mean-square error of approximation for expansion of power n=1 N and power dispersion were determined. Whereas the results converge badly and dispersion increased with the n grows, hence we can concludes, that vertical movements do not characterized global earth crust movement and denotes the unrelated character of these movement. Seemingly, the main cause of such movement origin is the local seismic events(earthquake, volcanic eruption and so on). It confirms by our conclusions about correspondence of vertical strain maximal gradient(and therefore vertical velocities) map of the earthquake distribution. In work the detailed analysis of obtained results for separate Earth’s regions was made.
基金Supported by National Key Technology R&D Program(No.2011BAG03B03)
文摘The three dimensional variable cross-section roll forming is a kind of new metal forming technol- ogy which combines large forming force, multi-axis linkage movement and space synergic movement, and the sequential synergic movement of the ganged roller group is used to complete the metal sheet forming according to the shape of the complicated and variable forming part data. The control system should meet the demands of quick response to the test requirements of the product part. A new kind of real time data driving multi-axis linkage and synergic movement control strategy of 3D roll forming is put forward in the paper. In the new control strategy, the forming data are automatically generated according to the shape of the parts, and the multi-axis linkage movement together with cooperative motion among the six stands of the 3D roll forming machine is driven by the real-time information, and the control nodes are also driven by the forming data. The new control strategy is applied to a 48 axis 3D roll forming machine developed by our research center, and the control servo period is less than 10ms. A forming experiment of variable cross section part is carried out, and the forming preci- sion is better than ＋ 0.5mm by the control strategy. The result of the experiment proves that the control strategy has significant potentiality for the development of 3D roll forming production line with large scale, multi-axis ganged and svner^ic movement
基金supported by Innovation Program of Shanghai Municipal Education Commission of China(No.14YZ169)
文摘The novel eye-based human-computer interaction(HCI) system aims to provide people, especially, disabled persons,a new way of communication with surroundings. It adopts a series of continual eye movements as input to perform simple control activities. Identification of eye movements is the crucial technology in these eye-based HCI systems. At present, researches on eye movement identification mainly focus on frontal face images. In fact, acquisition of non-frontal face images is more reasonable in real applications. In this paper, we discuss the identification process of eye movements from non-frontal face images. Firstly, the original head-shoulder images of 0?–±60?azimuths are sampled without any auxiliary light source. Secondly, the non-frontal face region is detected by using the Adaboost cascade classifiers. After that, we roughly extract eye windows by the integral projection function.Then, we propose a new method to calculate the x- y coordinates of the pupil center point by searching the minimal intensity value in the eye windows. According to the trajectory of the pupil center points, different eye movements(eye moving left, right, up or down)are successfully identified. A set of experiments is presented.
文摘The accuracy and repeatability of the laser interferometer measurement system （LIMS） are often limited by the mirror surface error that comes from the mirror surface shape and distortion. This paper describes a new method to calibrate mirror map on ultraprecise movement stage （UPMS） with nanopositioning and to make a real-time compensation for the mirror surface error by using mirror map data tables with the software algorithm. Based on the mirror map test model, the factors affecting mirror map are analyzed through geometric method on the UPMS with six digrees of freedom. Dam processing methods including spline interpolation and spline offsets are used to process the raw sampling data to build mirror map tables. The linear interpolation as compensation method to make a real-time correction on the stage mirror unflatness is adopted and the correction formulas are illuminated. In this way, the measurement accuracy of the system is obviously improved from 40 nm to 5 nm.
文摘Vehicle turning movement data from signalized intersections is utilized for numerous applications in the field of transportation. Such applications include real-time adaptive signal control, dynamic traffic assignment, and traffic demand estimation. However, it is very time consuming and costly to obtain vehicle turning movement information manually. Previous efforts to simplify this process were focused on solving the problem using an O-D matrix, but this method proved to be inaccurate and unreliable with the existing data acquisition system. Another study involved the identification of vehicle turning movements from the detector information, but the presence of shared lanes led to uncertainties in vehicle matching, thus limiting application of the method only to intersections without shared lanes. In light of those unsuccessful attempts, this paper develops and tests a system called the Automatic Turning Movement Identification System (ATMIS), which estimates vehicle turning movements at a signalized intersection in real time, regardless of its geometry. The results from lab experiments as well as a field test show that the algorithm is very promising and may potentially be expanded for field applications.
基金supported by the National Natural Science Foundations of China No.82230030,No.81871492(Y.L.)and No.82170996(D.H.)Beijing International Science and Technology Cooperation Project No.Z221100002722003(Y.L.)+3 种基金Beijing Natural Science Foundation No.L23002,No.L234017(Y.L.)Ten-Thousand Talents Program No.QNBJ2019-2(Y.L.)Key R&D Plan of Ningxia Hui Autonomous Region No.2020BCG01001(Y.L.)Innovative Research Team of High-level Local Universities in Shanghai No.SHSMU-ZLCX20212402(Y.L.).
文摘Pyroptosis,an inflammatory caspase-dependent programmed cell death,plays a vital role in maintaining tissue homeostasis and activating inflammatory responses.Orthodontic tooth movement(OTM)is an aseptic force-induced inflammatory bone remodeling process mediated by the activation of periodontal ligament(PDL)progenitor cells.However,whether and how force induces PDL progenitor cell pyroptosis,thereby influencing OTM and alveolar bone remodeling remains unknown.In this study,we found that mechanical force induced the expression of pyroptosis-related markers in rat OTM and alveolar bone remodeling process.Blocking or enhancing pyroptosis level could suppress or promote OTM and alveolar bone remodeling respectively.Using Caspase-1^(−/−)mice,we further demonstrated that the functional role of the force-induced pyroptosis in PDL progenitor cells depended on Caspase-1.Moreover,mechanical force could also induce pyroptosis in human ex-vivo force-treated PDL progenitor cells and in compressive force-loaded PDL progenitor cells in vitro,which influenced osteoclastogenesis.Mechanistically,transient receptor potential subfamily V member 4 signaling was involved in force-induced Caspase-1-dependent pyroptosis in PDL progenitor cells.Overall,this study suggested a novel mechanism contributing to the modulation of osteoclastogenesis and alveolar bone remodeling under mechanical stimuli,indicating a promising approach to accelerate OTM by targeting Caspase-1.
