AIM: To validate the protocol described here to be used in future clinical trials related to the effect of laser therapy on dental pulp. METHODS: Histologically treated samples from eight human healthy premolar teeth ...AIM: To validate the protocol described here to be used in future clinical trials related to the effect of laser therapy on dental pulp. METHODS: Histologically treated samples from eight human healthy premolar teeth obtained from the middle root level were distributed in four groups: group 1(G1) absolute control; group 2(G2) only laser irradiation; group 3(G3) exposed only to orthodontics; and group 4(G4) treated with orthodontics and laser. Laser treatment was performed at 830 nm wavelength, 100 mW(energy 80 J/cm2, 2.2 J), for 22 s in the vestibular surface and 22 s in the palatal surface, 1 mm away from the dental root mucosa. Three staining methods were performed: hematoxylin-eosin(HE), Masson's Trichrome method and Gomori's method.RESULTS: The pulp histology parameters were evaluated and the results classified in to 3 parts: an inflammatory response, soft tissue response(dental pulp) and hard tissue response(dentin and predentin). There was no inflammation(chronic or acute) in any of the evaluated groups. The zones of pulp necrosis were found in one premolar of G3 and in one of G4; in groups G2 and G4 there was higher angiogenesis than in the other two groups. G4 group presented the highest level of vascularization. A reduced nerve density was observed in G3. A G2 specimen showed increased nerve density. A higher rate of calcification was observed in G1 compared to G2. Denticles, either real or false, were observed in G1, G2 and G3. Sclerosis of dentin and focal dentin loss was observed among all the groups. Secondary dentin was present in one sample in G1 and G2. A necrosis zone was found in one sample of G3 and G4. No differences between groups were observed in the odontoblast irregularity layer but the layer was wider in the group treated with laser only. A notable difference was detected in reduction of the cell-free layer between the groups G1 and G4. The findings in pulp tissue favor its adaptative response against dental movement induced by orthodontics. No definitive conclusions may be derived as this is a pilot study. CONCLUSION: The protocol described here was shown to be an effective method to evaluate changes in dental pulp submitted to low level laser in teeth under orthodontic movement.展开更多
Based on the precise reieveling data of more than 260,000 km carried out from 1950 to 1991 in the Chinese mainland,recent crustal vertical movement is studied.By means of some quantitative indices,such as the pattern ...Based on the precise reieveling data of more than 260,000 km carried out from 1950 to 1991 in the Chinese mainland,recent crustal vertical movement is studied.By means of some quantitative indices,such as the pattern of crustal vertical movement,the intensity of differential movement,the maximum gradient and its distribution,etc.,the properties of movements are analyzed on a large scale.The results suggest that all the properties have a profound tectonic background of their own and are closely related to the zoning and seismic activity of active subplates.The driving force for the movement comes mainly from the northward push of the India plate acting on the Eurasia plate.The effects of motions of the Pacific and Philippine Sea plates in the east are much less significant.展开更多
Objective:To reveal the neural network of active and passive hand movements. Method:Seven healthy aged people were checked, and acquired functional magnetic resonance imaging data on a 1.5T scanner. Active movement co...Objective:To reveal the neural network of active and passive hand movements. Method:Seven healthy aged people were checked, and acquired functional magnetic resonance imaging data on a 1.5T scanner. Active movement consisted of repetitive grasping and loosening of hand; passive movement involved the same movement performed by examiner. Both types of hand movements were assessed separately. These data were analysed by Statistical Parametric Mapping Microsoft. Result:The main activated brain areas were the contralateral supplemental motor area, primary motor area, primary sensory area and the ipsilateral cerebellum when subjects gripped right hands actively and passively. The supplemental area was less active in passive hand movement than active hand movement. The activated brain areas were mainly within Brodmann area 4 during active hand movement; in the contrast, the voxels triggered by passive movement were mainly within Brodmann areas 3,1,2 areas. Conclusion:The results suggest that the neural networks of passive and active tasks spared some common areas, and the passive movement could be as effective as active movement to facilitate the recovery of limbs motor function in patients with brain damage.展开更多
Against a background of climate change, Macao is very exposed to sea level rise （SLR） because of its low elevation, small size, and ongoing land reclamation. Therefore, we evaluate sea level changes in Macao, both h...Against a background of climate change, Macao is very exposed to sea level rise （SLR） because of its low elevation, small size, and ongoing land reclamation. Therefore, we evaluate sea level changes in Macao, both historical and, especially, possible future scenarios, aiming to provide knowledge and a framework to help accommodate and protect against future SLR. Sea level in Macao is now rising at an accelerated rate： 1.35 mm yr-1 over 1925-2010 and jumping to 4.2 mm yr I over 1970-2010, which outpaces the rise in global mean sea level. In addition, vertical land movement in Macao contributes little to local sea level change. In the future, the rate of SLR in Macao will be about 20% higher than the global average, as a consequence of a greater local warming tendency and strengthened northward winds. Specifically, the sea level is projected to rise 8-12, 22-51 and 35-118 cm by 2020, 2060 and 2100, respectively, depending on the emissions scenario and climate sensitivity. Under the --8.5 W m 2 Representative Concentration Pathway （RCP8.5） scenario the increase in sea level by 2100 will reach 65 118 cm--double that under RCP2.6. Moreover, the SLR will accelerate under RCP6.0 and RCP8.5, while remaining at a moderate and steady rate under RCP4.5 and RCP2.6. The key source of uncertainty stems from the emissions scenario and climate sensitivity, among which the discrepancies in SLR are small during the first half of the 21st century but begin to diverge thereafter.展开更多
Multi-level multi-scale resource selection models using machine learning were compared and contrasted for generating predictive maps of jaguar habitat (Panthera onca) in the Brazilian Pantanal. Multiple spatial scales...Multi-level multi-scale resource selection models using machine learning were compared and contrasted for generating predictive maps of jaguar habitat (Panthera onca) in the Brazilian Pantanal. Multiple spatial scales and temporal movement levels were run within several analytical modeling frameworks for comparison. Included in the analysis were multi-scale raster grains (30 m, 90 m, 180 m, 360 m, 720 m, 1440 m) and GPS collaring temporal movement levels (point, path, and step). Various analytical methods were used for comparison of models that could accommodate data structural levels (group, individual, case-control). Models compared included conditional logistic regression, generalized additive modeling (GAM), and classification regression trees, such as random forests (RF) and gradient boosted regression tree (GBM). The goals of the study were to discuss the potential and limitations for machine learning methods using GPS collaring data to produce predictive habitat suitability mapping using the various scales and levels available. Results indicated that choosing the appropriate temporal level and raster scale improved model outputs. Overall, larger level analytical modeling frameworks and those that used multi-scale raster grains showed the best model evaluation with the inherent condition that they predict a broader scale and subset of data. The identification of the appropriate spatial scale, temporal scale and statistical model need careful consideration in predictive mapping efforts.展开更多
文摘AIM: To validate the protocol described here to be used in future clinical trials related to the effect of laser therapy on dental pulp. METHODS: Histologically treated samples from eight human healthy premolar teeth obtained from the middle root level were distributed in four groups: group 1(G1) absolute control; group 2(G2) only laser irradiation; group 3(G3) exposed only to orthodontics; and group 4(G4) treated with orthodontics and laser. Laser treatment was performed at 830 nm wavelength, 100 mW(energy 80 J/cm2, 2.2 J), for 22 s in the vestibular surface and 22 s in the palatal surface, 1 mm away from the dental root mucosa. Three staining methods were performed: hematoxylin-eosin(HE), Masson's Trichrome method and Gomori's method.RESULTS: The pulp histology parameters were evaluated and the results classified in to 3 parts: an inflammatory response, soft tissue response(dental pulp) and hard tissue response(dentin and predentin). There was no inflammation(chronic or acute) in any of the evaluated groups. The zones of pulp necrosis were found in one premolar of G3 and in one of G4; in groups G2 and G4 there was higher angiogenesis than in the other two groups. G4 group presented the highest level of vascularization. A reduced nerve density was observed in G3. A G2 specimen showed increased nerve density. A higher rate of calcification was observed in G1 compared to G2. Denticles, either real or false, were observed in G1, G2 and G3. Sclerosis of dentin and focal dentin loss was observed among all the groups. Secondary dentin was present in one sample in G1 and G2. A necrosis zone was found in one sample of G3 and G4. No differences between groups were observed in the odontoblast irregularity layer but the layer was wider in the group treated with laser only. A notable difference was detected in reduction of the cell-free layer between the groups G1 and G4. The findings in pulp tissue favor its adaptative response against dental movement induced by orthodontics. No definitive conclusions may be derived as this is a pilot study. CONCLUSION: The protocol described here was shown to be an effective method to evaluate changes in dental pulp submitted to low level laser in teeth under orthodontic movement.
文摘Based on the precise reieveling data of more than 260,000 km carried out from 1950 to 1991 in the Chinese mainland,recent crustal vertical movement is studied.By means of some quantitative indices,such as the pattern of crustal vertical movement,the intensity of differential movement,the maximum gradient and its distribution,etc.,the properties of movements are analyzed on a large scale.The results suggest that all the properties have a profound tectonic background of their own and are closely related to the zoning and seismic activity of active subplates.The driving force for the movement comes mainly from the northward push of the India plate acting on the Eurasia plate.The effects of motions of the Pacific and Philippine Sea plates in the east are much less significant.
基金supported by the Key Projects of Shanghai Science and Technology on Biomedicine(NO.10DZ1950800)the Major Project of Shanghai Zhabei District Health Bureau (No. 2011ZD01)
文摘Objective:To reveal the neural network of active and passive hand movements. Method:Seven healthy aged people were checked, and acquired functional magnetic resonance imaging data on a 1.5T scanner. Active movement consisted of repetitive grasping and loosening of hand; passive movement involved the same movement performed by examiner. Both types of hand movements were assessed separately. These data were analysed by Statistical Parametric Mapping Microsoft. Result:The main activated brain areas were the contralateral supplemental motor area, primary motor area, primary sensory area and the ipsilateral cerebellum when subjects gripped right hands actively and passively. The supplemental area was less active in passive hand movement than active hand movement. The activated brain areas were mainly within Brodmann area 4 during active hand movement; in the contrast, the voxels triggered by passive movement were mainly within Brodmann areas 3,1,2 areas. Conclusion:The results suggest that the neural networks of passive and active tasks spared some common areas, and the passive movement could be as effective as active movement to facilitate the recovery of limbs motor function in patients with brain damage.
基金supported by the National Basic Research Program of China (Grant No. 2012CB955604)the National Outstanding Youth Science Fund Project of China (Grant No. 41425019)+1 种基金the National Natural Science Foundation of China (Grant Nos. 91337105, 41461144001, 41230527, and 41275083)Public science and technology research funds projects of ocean (201505013)
文摘Against a background of climate change, Macao is very exposed to sea level rise （SLR） because of its low elevation, small size, and ongoing land reclamation. Therefore, we evaluate sea level changes in Macao, both historical and, especially, possible future scenarios, aiming to provide knowledge and a framework to help accommodate and protect against future SLR. Sea level in Macao is now rising at an accelerated rate： 1.35 mm yr-1 over 1925-2010 and jumping to 4.2 mm yr I over 1970-2010, which outpaces the rise in global mean sea level. In addition, vertical land movement in Macao contributes little to local sea level change. In the future, the rate of SLR in Macao will be about 20% higher than the global average, as a consequence of a greater local warming tendency and strengthened northward winds. Specifically, the sea level is projected to rise 8-12, 22-51 and 35-118 cm by 2020, 2060 and 2100, respectively, depending on the emissions scenario and climate sensitivity. Under the --8.5 W m 2 Representative Concentration Pathway （RCP8.5） scenario the increase in sea level by 2100 will reach 65 118 cm--double that under RCP2.6. Moreover, the SLR will accelerate under RCP6.0 and RCP8.5, while remaining at a moderate and steady rate under RCP4.5 and RCP2.6. The key source of uncertainty stems from the emissions scenario and climate sensitivity, among which the discrepancies in SLR are small during the first half of the 21st century but begin to diverge thereafter.
文摘Multi-level multi-scale resource selection models using machine learning were compared and contrasted for generating predictive maps of jaguar habitat (Panthera onca) in the Brazilian Pantanal. Multiple spatial scales and temporal movement levels were run within several analytical modeling frameworks for comparison. Included in the analysis were multi-scale raster grains (30 m, 90 m, 180 m, 360 m, 720 m, 1440 m) and GPS collaring temporal movement levels (point, path, and step). Various analytical methods were used for comparison of models that could accommodate data structural levels (group, individual, case-control). Models compared included conditional logistic regression, generalized additive modeling (GAM), and classification regression trees, such as random forests (RF) and gradient boosted regression tree (GBM). The goals of the study were to discuss the potential and limitations for machine learning methods using GPS collaring data to produce predictive habitat suitability mapping using the various scales and levels available. Results indicated that choosing the appropriate temporal level and raster scale improved model outputs. Overall, larger level analytical modeling frameworks and those that used multi-scale raster grains showed the best model evaluation with the inherent condition that they predict a broader scale and subset of data. The identification of the appropriate spatial scale, temporal scale and statistical model need careful consideration in predictive mapping efforts.
