In 2001,Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of"aggregation-induced emission(AlE)".Unlike conventional flu...In 2001,Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of"aggregation-induced emission(AlE)".Unlike conventional fluorescent materials,AlE luminogens(AlEgens)emit weak or no fluorescence in solution but become highly fluorescent in aggregated or solid states,due to a mechanism known as restriction of intramolecular motions(RIM).Initially considered a purely inorganic chemical phenomenon,AIE was later applied in biomedicine to improve the sensitivity of immunoassays.Subsequently,AlE has been extensively explored in various biomedical applications,especially in cell imaging.Early studies achieved nonspecific cell imaging using nontargeted AlEgens,and later,specific cellular imaging was realized through the design of targeted AlEgens.These advancements have enabled the visualization of various biomacromolecules and intracellular organelles,providing valuable insights into cellular microenvironments and statuses.Neurological disorders affect over 3 billion people worldwide,highlighting the urgent need for advanced diagnostic and therapeutic tools.AlEgens offer promising opportunities for imaging the central nervous system(CNS),including nerve cells,neural tissues,and blood vessels.This review focuses on the application of AlEgens in CNS imaging,exploring their roles in the diagnosis of various neurological diseases.We will discuss the evolution and conclude with an outlook on the future challenges and opportunities for AlEgens in clinical diagnostics and therapeutics of CNS disorders.展开更多
基金supported by the Natural Science Foundation of the Sichuan Provincial Department of Science and Technology(no.2025ZNSFSC0738)Department of Chengdu Science and Technology(no.2024-YF05-01250-SN)+2 种基金Popularized Application Project of Sichuan Provincial Health Commission(no.chuan-gan-yan2023-214)National Natural Science Foundation of China(no.81603018)Tianfu Jincheng Laboratory,City of Future Medicine(no.TFJC-2024-JB003).
文摘In 2001,Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of"aggregation-induced emission(AlE)".Unlike conventional fluorescent materials,AlE luminogens(AlEgens)emit weak or no fluorescence in solution but become highly fluorescent in aggregated or solid states,due to a mechanism known as restriction of intramolecular motions(RIM).Initially considered a purely inorganic chemical phenomenon,AIE was later applied in biomedicine to improve the sensitivity of immunoassays.Subsequently,AlE has been extensively explored in various biomedical applications,especially in cell imaging.Early studies achieved nonspecific cell imaging using nontargeted AlEgens,and later,specific cellular imaging was realized through the design of targeted AlEgens.These advancements have enabled the visualization of various biomacromolecules and intracellular organelles,providing valuable insights into cellular microenvironments and statuses.Neurological disorders affect over 3 billion people worldwide,highlighting the urgent need for advanced diagnostic and therapeutic tools.AlEgens offer promising opportunities for imaging the central nervous system(CNS),including nerve cells,neural tissues,and blood vessels.This review focuses on the application of AlEgens in CNS imaging,exploring their roles in the diagnosis of various neurological diseases.We will discuss the evolution and conclude with an outlook on the future challenges and opportunities for AlEgens in clinical diagnostics and therapeutics of CNS disorders.
