"桑吉"轮溢油事故是世界航运史上首例载运凝析油油船被撞失火的船舶全损事故。从船员和管理的视角探究"桑吉"轮因碰撞导致溢油事故的主要致因和深层次原因,采用能量踪迹和屏障分析理论,对"桑吉"轮和"..."桑吉"轮溢油事故是世界航运史上首例载运凝析油油船被撞失火的船舶全损事故。从船员和管理的视角探究"桑吉"轮因碰撞导致溢油事故的主要致因和深层次原因,采用能量踪迹和屏障分析理论,对"桑吉"轮和"水晶"轮碰撞事故进行屏障分析,构建了基于管理疏忽与危险树(MORT,Management Oversight and Risk Tree)的"桑吉"轮因碰撞导致溢油事故的致因分析模型,并利用结构熵权法计算因子权重并排序。结果表明:事故的主要原因为船员违章操作、责任心不强、专业水平低,其中,船员违章操作对事故的影响最大;事故深层次的原因为航运公司对船员专业技能培训不到位、海事监管机构对海员选拔和资质认证把关不严、航运公司的安全教育和现场监督检查不到位。研究结论可为剖析由船舶碰撞引起的溢油事故的致因因素提供理论参考。展开更多
AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the al...AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining. RESULTS: Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A expression was only detectable in wild-type animals. Consequently, the onset of liver mass restoration was retarded as measured by MRI volumetry and mortality was significantly higher in the transgenic group. CONCLUSION: Our data demonstrate for the first time an involvement of the death receptor molecule MORT1/ FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.展开更多
1422年,法国国王查理六世去世,查理七世继承王位.在宣布这一消息时,一句“Le roi est mort,vive le roi!”（国王驾崩,国王万岁!）被用来表示变革来临时王权的延续,目前光纤通道（FC）存储连接领域的情况就是如此.尽管人们认为FC已经死...1422年,法国国王查理六世去世,查理七世继承王位.在宣布这一消息时,一句“Le roi est mort,vive le roi!”（国王驾崩,国王万岁!）被用来表示变革来临时王权的延续,目前光纤通道（FC）存储连接领域的情况就是如此.尽管人们认为FC已经死亡或在垂死挣扎,但实际上它正借助技术创新不断发展,继续在无损高速高性能存储网络领域占据主导地位.光纤通道死了,光纤通道永生!展开更多
文摘"桑吉"轮溢油事故是世界航运史上首例载运凝析油油船被撞失火的船舶全损事故。从船员和管理的视角探究"桑吉"轮因碰撞导致溢油事故的主要致因和深层次原因,采用能量踪迹和屏障分析理论,对"桑吉"轮和"水晶"轮碰撞事故进行屏障分析,构建了基于管理疏忽与危险树(MORT,Management Oversight and Risk Tree)的"桑吉"轮因碰撞导致溢油事故的致因分析模型,并利用结构熵权法计算因子权重并排序。结果表明:事故的主要原因为船员违章操作、责任心不强、专业水平低,其中,船员违章操作对事故的影响最大;事故深层次的原因为航运公司对船员专业技能培训不到位、海事监管机构对海员选拔和资质认证把关不严、航运公司的安全教育和现场监督检查不到位。研究结论可为剖析由船舶碰撞引起的溢油事故的致因因素提供理论参考。
基金Supported by the Intramural grant (MAIFOR) to M.S.
文摘AIM: To explore the role of the adaptor molecule in liver regeneration after partial hepatectomy (PH). METHODS: We used transgenic mice expressing an N-terminal truncated form of MORT1/FADD under the control of the albumin promoter. As previously shown, this transgenic protein abrogated CD95- and CD120a-mediated apoptosis in the liver. Cyclin A expression was detected using Western blotting. ELISA and RT-PCR were used to detect IL-6 and IL-6 mRNA, respectively. DNA synthesis in liver tissue was measured by BrdU staining. RESULTS: Resection of 70% of the liver was followed by a reduced early regenerative response in the transgenic group at 36 h. Accordingly, 36 h after hepatectomy, cyclin A expression was only detectable in wild-type animals. Consequently, the onset of liver mass restoration was retarded as measured by MRI volumetry and mortality was significantly higher in the transgenic group. CONCLUSION: Our data demonstrate for the first time an involvement of the death receptor molecule MORT1/ FADD in liver regeneration, beyond its well described role as part of the intracellular death signaling pathway.
文摘1422年,法国国王查理六世去世,查理七世继承王位.在宣布这一消息时,一句“Le roi est mort,vive le roi!”（国王驾崩,国王万岁!）被用来表示变革来临时王权的延续,目前光纤通道（FC）存储连接领域的情况就是如此.尽管人们认为FC已经死亡或在垂死挣扎,但实际上它正借助技术创新不断发展,继续在无损高速高性能存储网络领域占据主导地位.光纤通道死了,光纤通道永生!
