As the second most abundant element on the Earth,silicon is widely used in materials science,medicinal chemistry,and organic synthesis[1].Especially in drug discovery,increasing attention has been paid to the“silicon...As the second most abundant element on the Earth,silicon is widely used in materials science,medicinal chemistry,and organic synthesis[1].Especially in drug discovery,increasing attention has been paid to the“silicon–carbon switch”strategy in optimizing lead molecules,as silicon can be considered as a carbon isostere due to the similarity in their chemical properties.The replacement of carbon atoms in bioactive molecules with silicon atoms can often result in higher activities compared to their non-silylated counterparts[2].展开更多
Cellular reprograming offers an opportunity to convert one somatic cell type into another,providing promising potential for disease modeling and regenerative medicine.This cell fate conversion can be achieved using li...Cellular reprograming offers an opportunity to convert one somatic cell type into another,providing promising potential for disease modeling and regenerative medicine.This cell fate conversion can be achieved using lineage-specific transcription factors,microRNAs or combinations of small molecules.A better understanding of how cell fate conversion is regulated will provide novel insights for precise manipulation of reprogramming,paving the way for developing novel strategies to regenerate the damaged tissue.展开更多
Cellular reprograming offers an opportunity to convert one somatic cell type into another,providing promising potential for disease modeling and regenerative medicine.This cell fate conversion can be achieved using li...Cellular reprograming offers an opportunity to convert one somatic cell type into another,providing promising potential for disease modeling and regenerative medicine.This cell fate conversion can be achieved using lineage-specific transcription factors,microRNAs or combinations of small molecules.A better understanding of how cell fate conversion is regulated will provide novel insights for precise manipulation of reprogramming,paving the way for developing novel strategies to regenerate the damaged tissue.展开更多
基金supported by the National Key R&D Program of China(2022YFA1506100)the National Natural Science Foundation of China(22471201,21901191,22501209,and 22503064)+2 种基金the China Postdoctoral Science Foundation(2023TQ0252 and 2023M742687)the Postdoctoral Foundation of Hubei Province(211000032)the Postdoctoral Fellowship Program of CPSF(GZC20231960)for financial support.
文摘As the second most abundant element on the Earth,silicon is widely used in materials science,medicinal chemistry,and organic synthesis[1].Especially in drug discovery,increasing attention has been paid to the“silicon–carbon switch”strategy in optimizing lead molecules,as silicon can be considered as a carbon isostere due to the similarity in their chemical properties.The replacement of carbon atoms in bioactive molecules with silicon atoms can often result in higher activities compared to their non-silylated counterparts[2].
文摘Cellular reprograming offers an opportunity to convert one somatic cell type into another,providing promising potential for disease modeling and regenerative medicine.This cell fate conversion can be achieved using lineage-specific transcription factors,microRNAs or combinations of small molecules.A better understanding of how cell fate conversion is regulated will provide novel insights for precise manipulation of reprogramming,paving the way for developing novel strategies to regenerate the damaged tissue.
文摘Cellular reprograming offers an opportunity to convert one somatic cell type into another,providing promising potential for disease modeling and regenerative medicine.This cell fate conversion can be achieved using lineage-specific transcription factors,microRNAs or combinations of small molecules.A better understanding of how cell fate conversion is regulated will provide novel insights for precise manipulation of reprogramming,paving the way for developing novel strategies to regenerate the damaged tissue.
