Methods for the localization of plant calmodulin by immuno-gold and immuno-peroxidase electron microscopy have been developed. In both corn root-cap cells and meristematic cells, calmodulin was found to be localized i...Methods for the localization of plant calmodulin by immuno-gold and immuno-peroxidase electron microscopy have been developed. In both corn root-cap cells and meristematic cells, calmodulin was found to be localized in the nucleus, cytoplasm, mitochondria as well as in the cell wall. In the meristematic cells, calmodulin was distinctly localized on the plasma membrane, cytoplasmic face of rough endoplasmic reticulum and polyribosomes. Characteristically, calmodulin was present in the amyloplasts of root-cap cells. The widespread distribution of calmodulin may reflect its pleiotropic functions in plant cellular activities.展开更多
Nonlocal set of orthogonal product states(OPSs)can improve the confidentiality of information when it is used to design quantum cryptographic protocols.It is a difficult question how to construct a nonlocal set of OPS...Nonlocal set of orthogonal product states(OPSs)can improve the confidentiality of information when it is used to design quantum cryptographic protocols.It is a difficult question how to construct a nonlocal set of OPSs on general multipartite and high dimensional quantum systems.Different from the previous works,we first present a novel method for constructing a nonlocal product set with 3d-2 members on C^(d)■C^(d)■C^(d)quantum system for d≥3.Then,we extend this construction method to C^(d_(1))■C^(d_(2))■C^(d_(3))quantum system and■_(i=1)^(n)C^(di)quantum system respectively,where 3≤d_(1)≤d_(2)≤d_(3)≤…≤dC_(d_(i))and n≥3.The nonlocal set of OPSs constructed by our method contains fewer elements than those constructed by the existing methods,except for one special case.More importantly,the set of states constructed by our method has a completely different structure from those constructed by the existing methods since our nonlocal set does not contain a“stopper”state.Our result is helpful to further understand the different structures of nonlocal sets on multipartite systems.展开更多
Existing Transformer-based image captioning models typically rely on the self-attention mechanism to capture long-range dependencies,which effectively extracts and leverages the global correlation of image features.Ho...Existing Transformer-based image captioning models typically rely on the self-attention mechanism to capture long-range dependencies,which effectively extracts and leverages the global correlation of image features.However,these models still face challenges in effectively capturing local associations.Moreover,since the encoder extracts global and local association features that focus on different semantic information,semantic noise may occur during the decoding stage.To address these issues,we propose the Local Relationship Enhanced Gated Transformer(LREGT).In the encoder part,we introduce the Local Relationship Enhanced Encoder(LREE),whose core component is the Local Relationship Enhanced Module(LREM).LREM consists of two novel designs:the Local Correlation Perception Module(LCPM)and the Local-Global Fusion Module(LGFM),which are beneficial for generating a comprehensive feature representation that integrates both global and local information.In the decoder part,we propose the Dual-level Multi-branch Gated Decoder(DMGD).It first creates multiple decoding branches to generate multi-perspective contextual feature representations.Subsequently,it employs the Dual-Level Gating Mechanism(DLGM)to model the multi-level relationships of these multi-perspective contextual features,enhancing their fine-grained semantics and intrinsic relationship representations.This ultimately leads to the generation of high-quality and semantically rich image captions.Experiments on the standard MSCOCO dataset demonstrate that LREGT achieves state-of-the-art performance,with a CIDEr score of 140.8 and BLEU-4 score of 41.3,significantly outperforming existing mainstream methods.These results highlight LREGT’s superiority in capturing complex visual relationships and resolving semantic noise during decoding.展开更多
Objective:To analyze the efficacy of whole-course local simultaneous integrated boost intensity-modulated radiotherapy(SIB-IMRT)on patients with locally advanced esophageal squamous cell carcinoma(ESCC).Methods:88 pat...Objective:To analyze the efficacy of whole-course local simultaneous integrated boost intensity-modulated radiotherapy(SIB-IMRT)on patients with locally advanced esophageal squamous cell carcinoma(ESCC).Methods:88 patients with ESCC admitted to the hospital between October 2022 and October 2024 were selected and randomly divided into two groups using a random number table.The experimental group received SIB-IMRT treatment,while the control group received conventional intensity-modulated radiotherapy(C-IMRT).The objective remission rate,immune function,tumor markers,and adverse reaction rate were compared between the two groups.Results:The objective remission rate in the experimental group was higher than that in the control group(P<0.05).Before treatment,there was no difference in immune function levels and tumor marker levels between the two groups(P>0.05).After treatment,the immune function levels in the experimental group were better than those in the control group,and the tumor marker levels were lower than those in the control group(P<0.05).The adverse reaction rate in the experimental group was lower than that in the control group(P<0.05).Conclusion:SIB-IMRT can improve the objective remission rate of patients with ESCC,protect their immune function,down-regulate tumor marker levels,and prevent side effects after treatment.展开更多
To improve the accuracy of indoor localization methods with channel state information(CSI)images,a localization method that used CSI images from selected multiple access points(APs)was proposed.The method had an off-l...To improve the accuracy of indoor localization methods with channel state information(CSI)images,a localization method that used CSI images from selected multiple access points(APs)was proposed.The method had an off-line phase and an on-line phase.In the off-line phase,three APs were selected from the four APs in the localization area based on the received signal strength indication(RSSI).Next,CSI data was collected from the three selected APs using a commercial Intel 5300 network interface card.A single-channel subimage was constructed for each selected AP by combining the amplitude information from different antennas and the phase difference information between neighboring antennas.These sub-images were then merged to form a three-channel RGB image,which was subsequently fed into the convolutional neural network(CNN)for training.The CNN model was saved upon completion of training.In the on-line phase,the CSI data from the target device was collected,converted into images using the same process as in the off-line phase,and fed into the well-trained CNN model.Finally,the real position of the target device was estimated using a weighted centroid algorithm based on the model’s output probabilities.The proposed method was validated in indoor environments using two datasets,achieving good localization accuracy.展开更多
In recent years,local government debt reduction and risk prevention have been the subjects of common concern to all parties.China's local government debt has different reasons in different historical periods,and t...In recent years,local government debt reduction and risk prevention have been the subjects of common concern to all parties.China's local government debt has different reasons in different historical periods,and the main line running through this is the development orientation of local governments.It is undeniable that local government debt has played an indelible role in China's rapid economic growth.However,due to historical restrictions,flood irrigation inevitably brought sediment all over the ground.Therefore,this paper intends to rethink the causes of local government debt from the perspective of the dual role of regional government and the main body of meso economics.展开更多
Polytrauma with significant bone and volumetric muscle loss presents substantial clinical challenges.Although immune responses significantly influence fracture healing post-polytrauma,the cellular and molecular underp...Polytrauma with significant bone and volumetric muscle loss presents substantial clinical challenges.Although immune responses significantly influence fracture healing post-polytrauma,the cellular and molecular underpinnings of polytrauma-induced immune dysregulation require further investigation.While previous studies examined either injury site tissue or systemic tissue(peripheral blood),our study uniquely investigated both systemic and local immune cells at the same time to better understand polytrauma-induced immune dysregulation and associated impaired bone healing.Using single-cell RNA sequencing(scRNA-seq)in a rat polytrauma model,we analyzed blood,bone marrow,and the local defect soft tissue to identify potential cellular and molecular targets involved in immune dysregulation.We identified a trauma-associated immunosuppressive myeloid(TIM)cell population that drives systemic immune dysregulation,immunosuppression,and potentially impaired bone healing.We found CD1d as a global marker for TIM cells in polytrauma.展开更多
Electron-electron interactions(EEIs),quantum interference,and the effects of disorder on transport properties are essential topics in condensed matter physics.A series of our characterization work demonstrates that th...Electron-electron interactions(EEIs),quantum interference,and the effects of disorder on transport properties are essential topics in condensed matter physics.A series of our characterization work demonstrates that the morphology of Bi_(2)Te_(3)/MnTe bilayer film mainly depends on the magnetic substrate's growth mode and thickness.We propose that the temperature-dependent quantum interference of the electron wave function caused by disorder drives the transition from weak antilocalization(WAL) to weak localization(WL).Due to spin regulation,WL under low fields originates from the ferromagnetism in MnTe.The quantum interference effect(QIE) model analysis gives the degree of impurity scattering of the electron wave function.The electron wave is scattered by impurities,which causes the Berry phase to change from π to 0,producing a complete WL behavior.The stacked structure provides tunable degrees of freedom,allowing for independent optimization of topological properties and magnetic order through preferential growth orientation of topological insulator(TI) and magnetic layers,respectively.展开更多
Urban investment bonds are another financing method designed by local governments in China to avoid the legal restrictions of urban economic construction, especially urban infrastructure construction under specific ec...Urban investment bonds are another financing method designed by local governments in China to avoid the legal restrictions of urban economic construction, especially urban infrastructure construction under specific economic environment. Although the issuance of urban investment bonds has eased the financing difficulties of local governments to a certain extent, the credit risk of urban investment bonds has gradually emerged due to the rapid increase in the number of urban investment companies and the expansion of the debt scale. In the borrowing process, not only the local government has expanded the land finance, but also the financial transparency has decreased, which will affect the regional economic development level, the urbanization process and the financial and credit status of the city investment companies themselves. Therefore, first of all, the local government should promote the improvement of the tax system, reduce the government's reliance on land finance, actively enhance the government's financial transparency, reduce the information asymmetry between bond issuers and market investors, and reduce the debt risk. Secondly, for the sake of stable growth of local economy, over-investment and development of cities should be avoided. Finally, standardize enterprises to increase credit guarantee, avoid false credit guarantee, and improve the system of public disclosure of corporate financial risk information and the role of third-party market capital in strictly guarding the market, providing a more reliable capital guarantee for the issuance and operation of China's bond market.展开更多
In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):104...In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):1045-1049]and Monrad and Rootzén[Probab.Theory Related Fields,1995,101(2):173-192].展开更多
Laser-welded Ti-6Al-4 V is prone to severe residual stresses,microstructural variation,and structural de-fects which are known detrimental to the mechanical properties of weld joints.Residual stress removal is typical...Laser-welded Ti-6Al-4 V is prone to severe residual stresses,microstructural variation,and structural de-fects which are known detrimental to the mechanical properties of weld joints.Residual stress removal is typically applied to weld joints for engineering purposes via heat treatment,in order to avoid prema-ture failure and performance degradation.In the present work,we found that proper welding residual stresses in laser-welded Ti-6Al-4 V sheets can maintain better ductility during uniaxial tension,as op-posed to the stress-relieved counterparts.A detailed experimental investigation has been performed on the deformation behaviours of Ti-6Al-4 V butt welds,including residual stress distribution characteriza-tions by focused ion beam ring-coring coupled with digital image correlation(FIB-DIC),X-ray comput-erized tomography(CT)for internal voids,and in-situ DIC analysis of the subregional strain evolutions.It was found that the pores preferentially distributed near the fusion zone(FZ)boundary,where the compressive residual stress was up to-330 MPa.The removal of residual stress resulted in a changed failure initiation site from the base material to the FZ boundary,the former with ductile and the latter with brittle fracture characteristics under tensile deformation.The combined effects of residual stresses,microstructures,and internal pores on the mechanical responses are discussed in detail.This work high-lights the importance of inevitable residual stress and pores in laser weld pieces,leading to key insights for post-welding treatment and service performance evaluations.展开更多
Neurons are highly polarized cells with axons reaching over a meter long in adult humans.To survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and m...Neurons are highly polarized cells with axons reaching over a meter long in adult humans.To survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and metabolic events,which need to be carried out at the right place,time,and intensity.Such mechanisms include axonal transport,local synthesis,and liquid-liquid phase separations.Alterations and malfunctions in these processes are correlated to neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS).展开更多
Finger Knuckle Print biometric plays a vital role in establishing security for real-time environments. The success of human authentication depends on high speed and accuracy. This paper proposed an integrated approach...Finger Knuckle Print biometric plays a vital role in establishing security for real-time environments. The success of human authentication depends on high speed and accuracy. This paper proposed an integrated approach of personal authentication using texture based Finger Knuckle Print (FKP) recognition in multiresolution domain. FKP images are rich in texture patterns. Recently, many texture patterns are proposed for biometric feature extraction. Hence, it is essential to review whether Local Binary Patterns or its variants perform well for FKP recognition. In this paper, Local Directional Pattern (LDP), Local Derivative Ternary Pattern (LDTP) and Local Texture Description Framework based Modified Local Directional Pattern (LTDF_MLDN) based feature extraction in multiresolution domain are experimented with Nearest Neighbor and Extreme Learning Machine (ELM) Classifier for FKP recognition. Experiments were conducted on PolYU database. The result shows that LDTP in Contourlet domain achieves a promising performance. It also proves that Soft classifier performs better than the hard classifier.展开更多
A multi-phase heterogeneous FeCoNi-based high-entropy alloy is developed to overcome the trade-off between strength and ductility.By alloying with a small amount of Cu and employing a rapid recrystalliza-tion process,...A multi-phase heterogeneous FeCoNi-based high-entropy alloy is developed to overcome the trade-off between strength and ductility.By alloying with a small amount of Cu and employing a rapid recrystalliza-tion process,it exhibits a good combination of yield strength(roughly 1300 MPa)and ductility(approach-ing 20%).Firstly,a multi-phase heterogeneous structure is tailored ranging from nano to micron.Cu is efficiently precipitated as nanoscale clusters(4.2 nm),high-density cuboidal L1_(2) particles(20-40 nm)and L2_(1) particles(500-800 nm)are found to be embedded in the matrix and a bimodal heterogeneous grain structure(1-40μm)is constructed.Secondly,the introduction of Cu effectively suppresses the pre-cipitation of coarse L21 phase at grain boundaries,reducing its volume fraction by 80%and replaced by smaller-scale continuous precipitations within the grains.Thirdly,the high mixing enthalpy gap of Cu and the matrix leads to the formation of local chemical fluctuation and the consequential rugged topog-raphy in the matrix,which result in retarded dislocation motion and promotes dislocation plugging and interlocking during strain,enhancing yield stress and work hardening rate.This study provides a valuable perspective to enhance strength and ductility via enlarged local chemical fluctuation-tailored multi-phase heterogeneous structures.展开更多
Spectrum-based fault localization (SBFL) generates a ranked list of suspicious elements by using the program execution spectrum, but the excessive number of elements ranked in parallel results in low localization accu...Spectrum-based fault localization (SBFL) generates a ranked list of suspicious elements by using the program execution spectrum, but the excessive number of elements ranked in parallel results in low localization accuracy. Most researchers consider intra-class dependencies to improve localization accuracy. However, some studies show that inter-class method call type faults account for more than 20%, which means such methods still have certain limitations. To solve the above problems, this paper proposes a two-phase software fault localization based on relational graph convolutional neural networks (Two-RGCNFL). Firstly, in Phase 1, the method call dependence graph (MCDG) of the program is constructed, the intra-class and inter-class dependencies in MCDG are extracted by using the relational graph convolutional neural network, and the classifier is used to identify the faulty methods. Then, the GraphSMOTE algorithm is improved to alleviate the impact of class imbalance on classification accuracy. Aiming at the problem of parallel ranking of element suspicious values in traditional SBFL technology, in Phase 2, Doc2Vec is used to learn static features, while spectrum information serves as dynamic features. A RankNet model based on siamese multi-layer perceptron is constructed to score and rank statements in the faulty method. This work conducts experiments on 5 real projects of Defects4J benchmark. Experimental results show that, compared with the traditional SBFL technique and two baseline methods, our approach improves the Top-1 accuracy by 262.86%, 29.59% and 53.01%, respectively, which verifies the effectiveness of Two-RGCNFL. Furthermore, this work verifies the importance of inter-class dependencies through ablation experiments.展开更多
The fast growth of mobile autonomous machines from traditional equipment to unmanned autonomous vehicles has fueled the demand for accurate and reliable localization solutions in diverse application domains.Ultra Wide...The fast growth of mobile autonomous machines from traditional equipment to unmanned autonomous vehicles has fueled the demand for accurate and reliable localization solutions in diverse application domains.Ultra Wide Band(UWB)technology has emerged as a promising candidate for addressing this need,offering high precision,immunity to multipath interference,and robust performance in challenging environments.In this comprehensive survey,we systematically explore UWB-based localization for mobile autonomous machines,spanning from fundamental principles to future trends.To the best of our knowledge,this review paper stands as the pioneer in systematically dissecting the algorithms of UWB-based localization for mobile autonomous machines,covering a spectrum from bottom-ranging schemes to advanced sensor fusion,error mitigation,and optimization techniques.By synthesizing existing knowledge,evaluating current methodologies,and highlighting future trends,this review aims to catalyze progress and innovation in the field,unlocking new opportunities for mobile autonomous machine applications across diverse industries and domains.Thus,it serves as a valuable resource for researchers,practitioners,and stakeholders interested in advancing the state-of-the-art UWB-based localization for mobile autonomous machines.展开更多
The proposed hybrid optimization algorithm integrates particle swarm optimizatio(PSO)with Ant Colony Optimization(ACO)to improve a number of pitfalls within PSO methods traditionally considered and/or applied to indus...The proposed hybrid optimization algorithm integrates particle swarm optimizatio(PSO)with Ant Colony Optimization(ACO)to improve a number of pitfalls within PSO methods traditionally considered and/or applied to industrial robots.Particle Swarm Optimization may frequently suffer from local optima and inaccuracies in identifying the geometric parameters,which are necessary for applications requiring high-accuracy performances.The proposed approach integrates pheromone-based learning of ACO with the D-H method of developing an error model;hence,the global search effectiveness together with the convergence accuracy is further improved.Comparison studies of the hybrid PSO-ACO algorithm show higher precision and effectiveness in the optimization of geometric error parameters compared to the traditional methods.This is a remarkable reduction of localization errors,thus yielding accuracy and reliability in industrial robotic systems,as the results show.This approach improves performance in those applications that demand high geometric calibration by reducing the geometric error.The paper provides an overview of input for developing robotics and automation,giving importance to precision in industrial engineering.The proposed hybrid methodology is a good way to enhance the working accuracy and effectiveness of industrial robots and shall enable their wide application to complex tasks that require a high degree of accuracy.展开更多
文摘Methods for the localization of plant calmodulin by immuno-gold and immuno-peroxidase electron microscopy have been developed. In both corn root-cap cells and meristematic cells, calmodulin was found to be localized in the nucleus, cytoplasm, mitochondria as well as in the cell wall. In the meristematic cells, calmodulin was distinctly localized on the plasma membrane, cytoplasmic face of rough endoplasmic reticulum and polyribosomes. Characteristically, calmodulin was present in the amyloplasts of root-cap cells. The widespread distribution of calmodulin may reflect its pleiotropic functions in plant cellular activities.
基金supported by the National Natural Science Foundation of China(Grant No.62171264)the Natural Science Foundation of Shandong Province of China(Grant No.ZR2023MF080)the Natural Science Foundation of Beijing(Grant No.4252014).
文摘Nonlocal set of orthogonal product states(OPSs)can improve the confidentiality of information when it is used to design quantum cryptographic protocols.It is a difficult question how to construct a nonlocal set of OPSs on general multipartite and high dimensional quantum systems.Different from the previous works,we first present a novel method for constructing a nonlocal product set with 3d-2 members on C^(d)■C^(d)■C^(d)quantum system for d≥3.Then,we extend this construction method to C^(d_(1))■C^(d_(2))■C^(d_(3))quantum system and■_(i=1)^(n)C^(di)quantum system respectively,where 3≤d_(1)≤d_(2)≤d_(3)≤…≤dC_(d_(i))and n≥3.The nonlocal set of OPSs constructed by our method contains fewer elements than those constructed by the existing methods,except for one special case.More importantly,the set of states constructed by our method has a completely different structure from those constructed by the existing methods since our nonlocal set does not contain a“stopper”state.Our result is helpful to further understand the different structures of nonlocal sets on multipartite systems.
基金supported by the Natural Science Foundation of China(62473105,62172118)Nature Science Key Foundation of Guangxi(2021GXNSFDA196002)+1 种基金in part by the Guangxi Key Laboratory of Image and Graphic Intelligent Processing under Grants(GIIP2302,GIIP2303,GIIP2304)Innovation Project of Guang Xi Graduate Education(2024YCXB09,2024YCXS039).
文摘Existing Transformer-based image captioning models typically rely on the self-attention mechanism to capture long-range dependencies,which effectively extracts and leverages the global correlation of image features.However,these models still face challenges in effectively capturing local associations.Moreover,since the encoder extracts global and local association features that focus on different semantic information,semantic noise may occur during the decoding stage.To address these issues,we propose the Local Relationship Enhanced Gated Transformer(LREGT).In the encoder part,we introduce the Local Relationship Enhanced Encoder(LREE),whose core component is the Local Relationship Enhanced Module(LREM).LREM consists of two novel designs:the Local Correlation Perception Module(LCPM)and the Local-Global Fusion Module(LGFM),which are beneficial for generating a comprehensive feature representation that integrates both global and local information.In the decoder part,we propose the Dual-level Multi-branch Gated Decoder(DMGD).It first creates multiple decoding branches to generate multi-perspective contextual feature representations.Subsequently,it employs the Dual-Level Gating Mechanism(DLGM)to model the multi-level relationships of these multi-perspective contextual features,enhancing their fine-grained semantics and intrinsic relationship representations.This ultimately leads to the generation of high-quality and semantically rich image captions.Experiments on the standard MSCOCO dataset demonstrate that LREGT achieves state-of-the-art performance,with a CIDEr score of 140.8 and BLEU-4 score of 41.3,significantly outperforming existing mainstream methods.These results highlight LREGT’s superiority in capturing complex visual relationships and resolving semantic noise during decoding.
文摘Objective:To analyze the efficacy of whole-course local simultaneous integrated boost intensity-modulated radiotherapy(SIB-IMRT)on patients with locally advanced esophageal squamous cell carcinoma(ESCC).Methods:88 patients with ESCC admitted to the hospital between October 2022 and October 2024 were selected and randomly divided into two groups using a random number table.The experimental group received SIB-IMRT treatment,while the control group received conventional intensity-modulated radiotherapy(C-IMRT).The objective remission rate,immune function,tumor markers,and adverse reaction rate were compared between the two groups.Results:The objective remission rate in the experimental group was higher than that in the control group(P<0.05).Before treatment,there was no difference in immune function levels and tumor marker levels between the two groups(P>0.05).After treatment,the immune function levels in the experimental group were better than those in the control group,and the tumor marker levels were lower than those in the control group(P<0.05).The adverse reaction rate in the experimental group was lower than that in the control group(P<0.05).Conclusion:SIB-IMRT can improve the objective remission rate of patients with ESCC,protect their immune function,down-regulate tumor marker levels,and prevent side effects after treatment.
基金supported by Lanzhou Science and Technology Plan Project(No.2023-3-104)Gansu Province Higher Education Industry Support Plan Project(No.2023CYZC-40)Gansu Province Excellent Graduate“Innovation Star”Program(No.2023CXZX-546)。
文摘To improve the accuracy of indoor localization methods with channel state information(CSI)images,a localization method that used CSI images from selected multiple access points(APs)was proposed.The method had an off-line phase and an on-line phase.In the off-line phase,three APs were selected from the four APs in the localization area based on the received signal strength indication(RSSI).Next,CSI data was collected from the three selected APs using a commercial Intel 5300 network interface card.A single-channel subimage was constructed for each selected AP by combining the amplitude information from different antennas and the phase difference information between neighboring antennas.These sub-images were then merged to form a three-channel RGB image,which was subsequently fed into the convolutional neural network(CNN)for training.The CNN model was saved upon completion of training.In the on-line phase,the CSI data from the target device was collected,converted into images using the same process as in the off-line phase,and fed into the well-trained CNN model.Finally,the real position of the target device was estimated using a weighted centroid algorithm based on the model’s output probabilities.The proposed method was validated in indoor environments using two datasets,achieving good localization accuracy.
文摘In recent years,local government debt reduction and risk prevention have been the subjects of common concern to all parties.China's local government debt has different reasons in different historical periods,and the main line running through this is the development orientation of local governments.It is undeniable that local government debt has played an indelible role in China's rapid economic growth.However,due to historical restrictions,flood irrigation inevitably brought sediment all over the ground.Therefore,this paper intends to rethink the causes of local government debt from the perspective of the dual role of regional government and the main body of meso economics.
文摘Polytrauma with significant bone and volumetric muscle loss presents substantial clinical challenges.Although immune responses significantly influence fracture healing post-polytrauma,the cellular and molecular underpinnings of polytrauma-induced immune dysregulation require further investigation.While previous studies examined either injury site tissue or systemic tissue(peripheral blood),our study uniquely investigated both systemic and local immune cells at the same time to better understand polytrauma-induced immune dysregulation and associated impaired bone healing.Using single-cell RNA sequencing(scRNA-seq)in a rat polytrauma model,we analyzed blood,bone marrow,and the local defect soft tissue to identify potential cellular and molecular targets involved in immune dysregulation.We identified a trauma-associated immunosuppressive myeloid(TIM)cell population that drives systemic immune dysregulation,immunosuppression,and potentially impaired bone healing.We found CD1d as a global marker for TIM cells in polytrauma.
基金financially supported by the National Natural Science Foundation of China (Nos.52371204, 52201233,and 52031014)
文摘Electron-electron interactions(EEIs),quantum interference,and the effects of disorder on transport properties are essential topics in condensed matter physics.A series of our characterization work demonstrates that the morphology of Bi_(2)Te_(3)/MnTe bilayer film mainly depends on the magnetic substrate's growth mode and thickness.We propose that the temperature-dependent quantum interference of the electron wave function caused by disorder drives the transition from weak antilocalization(WAL) to weak localization(WL).Due to spin regulation,WL under low fields originates from the ferromagnetism in MnTe.The quantum interference effect(QIE) model analysis gives the degree of impurity scattering of the electron wave function.The electron wave is scattered by impurities,which causes the Berry phase to change from π to 0,producing a complete WL behavior.The stacked structure provides tunable degrees of freedom,allowing for independent optimization of topological properties and magnetic order through preferential growth orientation of topological insulator(TI) and magnetic layers,respectively.
文摘Urban investment bonds are another financing method designed by local governments in China to avoid the legal restrictions of urban economic construction, especially urban infrastructure construction under specific economic environment. Although the issuance of urban investment bonds has eased the financing difficulties of local governments to a certain extent, the credit risk of urban investment bonds has gradually emerged due to the rapid increase in the number of urban investment companies and the expansion of the debt scale. In the borrowing process, not only the local government has expanded the land finance, but also the financial transparency has decreased, which will affect the regional economic development level, the urbanization process and the financial and credit status of the city investment companies themselves. Therefore, first of all, the local government should promote the improvement of the tax system, reduce the government's reliance on land finance, actively enhance the government's financial transparency, reduce the information asymmetry between bond issuers and market investors, and reduce the debt risk. Secondly, for the sake of stable growth of local economy, over-investment and development of cities should be avoided. Finally, standardize enterprises to increase credit guarantee, avoid false credit guarantee, and improve the system of public disclosure of corporate financial risk information and the role of third-party market capital in strictly guarding the market, providing a more reliable capital guarantee for the issuance and operation of China's bond market.
基金Supported by NSFC(Nos.11661025,12161024)Natural Science Foundation of Guangxi(Nos.2020GXNSFAA159118,2021GXNSFAA196045)+2 种基金Guangxi Science and Technology Project(No.Guike AD20297006)Training Program for 1000 Young and Middle-aged Cadre Teachers in Universities of GuangxiNational College Student's Innovation and Entrepreneurship Training Program(No.202110595049)。
文摘In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):1045-1049]and Monrad and Rootzén[Probab.Theory Related Fields,1995,101(2):173-192].
基金supported by the National Key Re-search&Development Plan of China(No.2020YFA0405900)the Major Research Plan of the National Natural Science Foundation of China(No.92263201)Y.P.Xia would like to thank the support by the Jiangsu Funding Program for Excellent Postdoctoral Talent.All authors thank the Advanced Material Research Institute of Jiangsu Industrial Technology Research Institute(JITRI,Suzhou,China)for the experimental support.
文摘Laser-welded Ti-6Al-4 V is prone to severe residual stresses,microstructural variation,and structural de-fects which are known detrimental to the mechanical properties of weld joints.Residual stress removal is typically applied to weld joints for engineering purposes via heat treatment,in order to avoid prema-ture failure and performance degradation.In the present work,we found that proper welding residual stresses in laser-welded Ti-6Al-4 V sheets can maintain better ductility during uniaxial tension,as op-posed to the stress-relieved counterparts.A detailed experimental investigation has been performed on the deformation behaviours of Ti-6Al-4 V butt welds,including residual stress distribution characteriza-tions by focused ion beam ring-coring coupled with digital image correlation(FIB-DIC),X-ray comput-erized tomography(CT)for internal voids,and in-situ DIC analysis of the subregional strain evolutions.It was found that the pores preferentially distributed near the fusion zone(FZ)boundary,where the compressive residual stress was up to-330 MPa.The removal of residual stress resulted in a changed failure initiation site from the base material to the FZ boundary,the former with ductile and the latter with brittle fracture characteristics under tensile deformation.The combined effects of residual stresses,microstructures,and internal pores on the mechanical responses are discussed in detail.This work high-lights the importance of inevitable residual stress and pores in laser weld pieces,leading to key insights for post-welding treatment and service performance evaluations.
文摘Neurons are highly polarized cells with axons reaching over a meter long in adult humans.To survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and metabolic events,which need to be carried out at the right place,time,and intensity.Such mechanisms include axonal transport,local synthesis,and liquid-liquid phase separations.Alterations and malfunctions in these processes are correlated to neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS).
文摘Finger Knuckle Print biometric plays a vital role in establishing security for real-time environments. The success of human authentication depends on high speed and accuracy. This paper proposed an integrated approach of personal authentication using texture based Finger Knuckle Print (FKP) recognition in multiresolution domain. FKP images are rich in texture patterns. Recently, many texture patterns are proposed for biometric feature extraction. Hence, it is essential to review whether Local Binary Patterns or its variants perform well for FKP recognition. In this paper, Local Directional Pattern (LDP), Local Derivative Ternary Pattern (LDTP) and Local Texture Description Framework based Modified Local Directional Pattern (LTDF_MLDN) based feature extraction in multiresolution domain are experimented with Nearest Neighbor and Extreme Learning Machine (ELM) Classifier for FKP recognition. Experiments were conducted on PolYU database. The result shows that LDTP in Contourlet domain achieves a promising performance. It also proves that Soft classifier performs better than the hard classifier.
基金financial support from the National Natural Science Foundation of China(Nos.52104306,52274301,52334009)the Aeronautical Science Foundation of China(No.2023Z0530S6005)+3 种基金the National Key Research and Development Program of China(No.2023YFB3712401)the Science and Technology Commission of Shanghai Municipality(No.21DZ1208900)the Academician Workstation of Kunming University of Science and Technology(2024),the Ningbo Yongjiang Talent-Introduction Programme(No.2022A-023-C)the Zhejiang Phenomenological Materials Technology Co.,Ltd.,China.
文摘A multi-phase heterogeneous FeCoNi-based high-entropy alloy is developed to overcome the trade-off between strength and ductility.By alloying with a small amount of Cu and employing a rapid recrystalliza-tion process,it exhibits a good combination of yield strength(roughly 1300 MPa)and ductility(approach-ing 20%).Firstly,a multi-phase heterogeneous structure is tailored ranging from nano to micron.Cu is efficiently precipitated as nanoscale clusters(4.2 nm),high-density cuboidal L1_(2) particles(20-40 nm)and L2_(1) particles(500-800 nm)are found to be embedded in the matrix and a bimodal heterogeneous grain structure(1-40μm)is constructed.Secondly,the introduction of Cu effectively suppresses the pre-cipitation of coarse L21 phase at grain boundaries,reducing its volume fraction by 80%and replaced by smaller-scale continuous precipitations within the grains.Thirdly,the high mixing enthalpy gap of Cu and the matrix leads to the formation of local chemical fluctuation and the consequential rugged topog-raphy in the matrix,which result in retarded dislocation motion and promotes dislocation plugging and interlocking during strain,enhancing yield stress and work hardening rate.This study provides a valuable perspective to enhance strength and ductility via enlarged local chemical fluctuation-tailored multi-phase heterogeneous structures.
基金funded by the Youth Fund of the National Natural Science Foundation of China(Grant No.42261070).
文摘Spectrum-based fault localization (SBFL) generates a ranked list of suspicious elements by using the program execution spectrum, but the excessive number of elements ranked in parallel results in low localization accuracy. Most researchers consider intra-class dependencies to improve localization accuracy. However, some studies show that inter-class method call type faults account for more than 20%, which means such methods still have certain limitations. To solve the above problems, this paper proposes a two-phase software fault localization based on relational graph convolutional neural networks (Two-RGCNFL). Firstly, in Phase 1, the method call dependence graph (MCDG) of the program is constructed, the intra-class and inter-class dependencies in MCDG are extracted by using the relational graph convolutional neural network, and the classifier is used to identify the faulty methods. Then, the GraphSMOTE algorithm is improved to alleviate the impact of class imbalance on classification accuracy. Aiming at the problem of parallel ranking of element suspicious values in traditional SBFL technology, in Phase 2, Doc2Vec is used to learn static features, while spectrum information serves as dynamic features. A RankNet model based on siamese multi-layer perceptron is constructed to score and rank statements in the faulty method. This work conducts experiments on 5 real projects of Defects4J benchmark. Experimental results show that, compared with the traditional SBFL technique and two baseline methods, our approach improves the Top-1 accuracy by 262.86%, 29.59% and 53.01%, respectively, which verifies the effectiveness of Two-RGCNFL. Furthermore, this work verifies the importance of inter-class dependencies through ablation experiments.
文摘The fast growth of mobile autonomous machines from traditional equipment to unmanned autonomous vehicles has fueled the demand for accurate and reliable localization solutions in diverse application domains.Ultra Wide Band(UWB)technology has emerged as a promising candidate for addressing this need,offering high precision,immunity to multipath interference,and robust performance in challenging environments.In this comprehensive survey,we systematically explore UWB-based localization for mobile autonomous machines,spanning from fundamental principles to future trends.To the best of our knowledge,this review paper stands as the pioneer in systematically dissecting the algorithms of UWB-based localization for mobile autonomous machines,covering a spectrum from bottom-ranging schemes to advanced sensor fusion,error mitigation,and optimization techniques.By synthesizing existing knowledge,evaluating current methodologies,and highlighting future trends,this review aims to catalyze progress and innovation in the field,unlocking new opportunities for mobile autonomous machine applications across diverse industries and domains.Thus,it serves as a valuable resource for researchers,practitioners,and stakeholders interested in advancing the state-of-the-art UWB-based localization for mobile autonomous machines.
文摘The proposed hybrid optimization algorithm integrates particle swarm optimizatio(PSO)with Ant Colony Optimization(ACO)to improve a number of pitfalls within PSO methods traditionally considered and/or applied to industrial robots.Particle Swarm Optimization may frequently suffer from local optima and inaccuracies in identifying the geometric parameters,which are necessary for applications requiring high-accuracy performances.The proposed approach integrates pheromone-based learning of ACO with the D-H method of developing an error model;hence,the global search effectiveness together with the convergence accuracy is further improved.Comparison studies of the hybrid PSO-ACO algorithm show higher precision and effectiveness in the optimization of geometric error parameters compared to the traditional methods.This is a remarkable reduction of localization errors,thus yielding accuracy and reliability in industrial robotic systems,as the results show.This approach improves performance in those applications that demand high geometric calibration by reducing the geometric error.The paper provides an overview of input for developing robotics and automation,giving importance to precision in industrial engineering.The proposed hybrid methodology is a good way to enhance the working accuracy and effectiveness of industrial robots and shall enable their wide application to complex tasks that require a high degree of accuracy.
