To researching the damage characteristics of typical logical chip modules in spacecraft due to plasma generated by hypervelocity impacts,we have established a triple Langmuir probe diagnostic system and a logical chip...To researching the damage characteristics of typical logical chip modules in spacecraft due to plasma generated by hypervelocity impacts,we have established a triple Langmuir probe diagnostic system and a logical chips measurement system,which were used to diagnose plasma characteristic parameters and the logical chip module＇s logical state changes due to the plasma created by a 7075 aluminum projectile hypervelocity impact on the 2A12 aluminum target.Three sets of experiments were performed with the collision speeds of 2.85 km/s,3.1 km/s and2.20 km/s,at the same incident angles of 30 degrees and logical chip module＇s positions by using a two-stage light gas gun loading system,a plasma characteristic parameters diagnostic system and a logical chip module＇s logical state measurement system,respectively.Electron temperature and density were measured at given position and azimuth,and damage estimation was performed for the logical chip module by using the data acquisition system.Experimental results showed that temporary damage could be induced on logical chip modules in spacecraft by plasma generated by hypervelocity impacts under the given experimental conditions and the sensors＇ position and azimuth.展开更多
Protein poly ADP-ribosylation（PARylation） is a widespread post-translational modification at DNA lesions,which is catalyzed by poly（ADP-ribose） polymerases（PARPs）.This modification regulates a number of biologic...Protein poly ADP-ribosylation（PARylation） is a widespread post-translational modification at DNA lesions,which is catalyzed by poly（ADP-ribose） polymerases（PARPs）.This modification regulates a number of biological processes including chromatin reorganization,DNA damage response（DDR）,transcriptional regulation,apoptosis,and mitosis.PARP1,functioning as a DNA damage sensor,can be activated by DNA lesions,forming PAR chains that serve as a docking platform for DNA repair factors with high biochemical complexity.Here,we highlight molecular insights into PARylation recognition,the expanding role of PARylation in DDR pathways,and the functional interaction between PARylation and ubiquitination,which will offer us a better understanding of the biological roles of this unique post-translational modification.展开更多
基金supported by National Natural Science Foundation of China(Nos.10972145,11272218,11472178)Program for Liaoning Excellent Talents in University of China(No.LR2013008)Open Foundation of Key Laboratory of Liaoning Weapon Science and Technology,Liaoning Province Talents Engineering Projects of China(No.2012921044)
文摘To researching the damage characteristics of typical logical chip modules in spacecraft due to plasma generated by hypervelocity impacts,we have established a triple Langmuir probe diagnostic system and a logical chips measurement system,which were used to diagnose plasma characteristic parameters and the logical chip module＇s logical state changes due to the plasma created by a 7075 aluminum projectile hypervelocity impact on the 2A12 aluminum target.Three sets of experiments were performed with the collision speeds of 2.85 km/s,3.1 km/s and2.20 km/s,at the same incident angles of 30 degrees and logical chip module＇s positions by using a two-stage light gas gun loading system,a plasma characteristic parameters diagnostic system and a logical chip module＇s logical state measurement system,respectively.Electron temperature and density were measured at given position and azimuth,and damage estimation was performed for the logical chip module by using the data acquisition system.Experimental results showed that temporary damage could be induced on logical chip modules in spacecraft by plasma generated by hypervelocity impacts under the given experimental conditions and the sensors＇ position and azimuth.
基金funded by the National Institutes of Health of the United States(Grant Nos.CA132755,CA187209,and GM108647)
文摘Protein poly ADP-ribosylation（PARylation） is a widespread post-translational modification at DNA lesions,which is catalyzed by poly（ADP-ribose） polymerases（PARPs）.This modification regulates a number of biological processes including chromatin reorganization,DNA damage response（DDR）,transcriptional regulation,apoptosis,and mitosis.PARP1,functioning as a DNA damage sensor,can be activated by DNA lesions,forming PAR chains that serve as a docking platform for DNA repair factors with high biochemical complexity.Here,we highlight molecular insights into PARylation recognition,the expanding role of PARylation in DDR pathways,and the functional interaction between PARylation and ubiquitination,which will offer us a better understanding of the biological roles of this unique post-translational modification.
