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Weak Co-AB-context for G_(C)-χ-injective Modules
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作者 YANG Qiang 《数学进展》 北大核心 2026年第1期103-119,共17页
In this paper,we introduce the notion of G_(C)-X-injective modules,where X denotes a class of left S-modules and C represents a faithfully semidualizing bimodule.Under the condition that X satisfies certain hypotheses... In this paper,we introduce the notion of G_(C)-X-injective modules,where X denotes a class of left S-modules and C represents a faithfully semidualizing bimodule.Under the condition that X satisfies certain hypotheses,some properties and some equivalent characterizations of G_(C)-X-injective modules are investigated,and we also show that the triple(■,cores■,■)is a weak co-AB-context.As an application,two complete cotorsion pairs and a new model structure in Mod S are given. 展开更多
关键词 C-X-injective module G_(C)-X-injective module cotorsion pair weak co-ABcontext
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Enhancing Lightweight Mango Disease Detection Model Performance through a Combined Attention Module
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作者 Wen-Tsai Sung Indra Griha TofikIsa Sung-Jung Hsiao 《Computers, Materials & Continua》 2026年第2期986-1016,共31页
Mango is a plant with high economic value in the agricultural industry;thus,it is necessary to maximize the productivity performance of the mango plant,which can be done by implementing artificial intelligence.In this... Mango is a plant with high economic value in the agricultural industry;thus,it is necessary to maximize the productivity performance of the mango plant,which can be done by implementing artificial intelligence.In this study,a lightweight object detection model will be developed that can detect mango plant conditions based on disease potential,so that it becomes an early detection warning system that has an impact on increasing agricultural productivity.The proposed lightweight model integrates YOLOv7-Tiny and the proposed modules,namely the C2S module.The C2S module consists of three sub-modules such as the convolutional block attention module(CBAM),the coordinate attention(CA)module,and the squeeze-and-excitation(SE)module.The dataset is constructed by eight classes,including seven classes of disease conditions and one class of health conditions.The experimental result shows that the proposed lightweight model has the optimal results,which increase by 13.15% of mAP50 compared to the original model YOLOv7-Tiny.While the mAP50:95 also achieved the highest results compared to other models,including YOLOv3-Tiny,YOLOv4-Tiny,YOLOv5,and YOLOv7-Tiny.The advantage of the proposed lightweightmodel is the adaptability that supports it in constrained environments,such as edge computing systems.This proposedmodel can support a robust,precise,and convenient precision agriculture system for the user. 展开更多
关键词 Mango lightweight model combined attention module C2S module precision agriculture
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An attention module integrated hybrid model for recognizing microseismic signals induced by high-pressure grouting in deep rock layers
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作者 Yongshu Zhang Lianchong Li +2 位作者 Wenqiang Mu Jian Chen Peng Chen 《International Journal of Mining Science and Technology》 2026年第3期595-613,共19页
Microseismic(MS)monitoring is an effective technique to detect mining-induced rock fractures.However,recognizing grouting-induced signals is challenging due to complex geological conditions in deep rock plates.Therefo... Microseismic(MS)monitoring is an effective technique to detect mining-induced rock fractures.However,recognizing grouting-induced signals is challenging due to complex geological conditions in deep rock plates.Therefore,a hybrid model(WM-ResNet50)integrating data enhancement,a deep convolutional neural network(CNN),and convolutional block attention modules(CBAM)was proposed.Firstly,an MS system was established at the Xieqiao coal mine in Anhui Province,China.MS waveforms and injection parameters were acquired during grouting.Secondly,signals were categorized based on time-frequency characteristics to build a dataset,which was divided into training,validation,and test sets at a ratio of 4:1:1.Subsequently,the performance of WM-ResNet50 was evaluated based on indices such as individual precision,total accuracy,recall,and loss function.The results indicated that WMResNet50 achieved an average recognition accuracy of 94.38%,surpassing that of a simple CNN(90.04%),ResNet18(91.72%),and ResNet50(92.48%).Finally,WM-ResNet50 was applied to monitor the whole process at laboratory tests and field cases.Both results affirmed the feasibility and effectiveness of MS inversion in predicting actual slurry diffusion ranges within deep rock layers.By comparison,it was revealed that the MS sources classified by WM-ResNet50 matched grouting records well.A solution to address insufficient diffusion under long-borehole grouting has been proposed.WM-ResNet50′s accuracy was validated through in-situ coring and XRD analysis for cement-based hydration products.This study provides a beneficial reference for similar rock signal processing and in-field grouting practices. 展开更多
关键词 Attention module Convolutional neural network Microseismic ROCK Grouting-induced signals Slurry diffusion
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微课驱动小学生英语自主学习能力提升的探究——以Module 5 Unit 9 Where will you go?第一课时自主学习为例
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作者 张兴 《视周刊》 2026年第1期34-35,共2页
一、微课设计:从知识传递到认知建构的范式转变1.微课定义微课是一种以短小精悍的数字视频为主要载体,围绕某个知识点、教学环节或特定教学主题而设计的结构化、情境化教学资源。其时长通常在5-10分钟之间,内容高度聚焦,重点突出,针对性... 一、微课设计:从知识传递到认知建构的范式转变1.微课定义微课是一种以短小精悍的数字视频为主要载体,围绕某个知识点、教学环节或特定教学主题而设计的结构化、情境化教学资源。其时长通常在5-10分钟之间,内容高度聚焦,重点突出,针对性强,符合学生的认知负荷与注意力特点,旨在通过精炼的内容和生动的呈现方式,激发学生学习兴趣,支持个性化、碎片化学习,促进自主探究与合作交流,是现代教育信息化背景下一种重要的教学辅助手段与课程资源形态。 展开更多
关键词 英语 module 5 Unit 9 能力提升 自主学习 微课
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An RMD-YOLOv11 Approach for Typical Defect Detection of PV Modules
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作者 Tao Geng Shuaibing Li +3 位作者 Yunyun Yun Yongqiang Kang Hongwei Li unmin Zhu 《Computers, Materials & Continua》 2026年第3期1804-1822,共19页
In order to address the challenges posed by complex background interference,high miss-detection rates of micro-scale defects,and limited model deployment efficiency in photovoltaic(PV)module defect detection,this pape... In order to address the challenges posed by complex background interference,high miss-detection rates of micro-scale defects,and limited model deployment efficiency in photovoltaic(PV)module defect detection,this paper proposes an efficient detection framework based on an improved YOLOv11 architecture.First,a Re-parameterized Convolution(RepConv)module is integrated into the backbone to enhance the model’s sensitivity to fine-grained defects—such as micro-cracks and hot spots—while maintaining high inference efficiency.Second,a Multi-Scale Feature Fusion Convolutional Block Attention Mechanism(MSFF-CBAM)is designed to guide the network toward critical defect regions by jointly modeling channel-wise and spatial attention.This mechanism effectively strengthens the specificity and robustness of feature representations.Third,a lightweight Dynamic Sampling Module(DySample)is employed to replace conventional upsampling operations,thereby improving the localization accuracy of small-scale defect targets.Experimental evaluations conducted on the PVEL-AD dataset demonstrate that the proposed RMDYOLOv11 model surpasses the baseline YOLOv11 in terms of mean Average Precision(mAP)@0.5,Precision,and Recall,achieving respective improvements of 4.70%,1.51%,and 5.50%.The model also exhibits notable advantages in inference speed and model compactness.Further validation on the ELPV dataset confirms the model’s generalization capability,showing respective performance gains of 1.99%,2.28%,and 1.45%across the same metrics.Overall,the enhanced model significantly improves the accuracy of micro-defect identification on PV module surfaces,effectively reducing both false negatives and false positives.This advancement provides a robust and reliable technical foundation for automated PV module defect detection. 展开更多
关键词 Photovoltaic(PV)modules YOLOv11 re-parameterization convolution attention mechanism dynamic upsampling
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Human Activity Recognition Using a CNN with an Enhanced Convolutional Block Attention Module
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作者 HU Biling TONG Yu 《Wuhan University Journal of Natural Sciences》 2026年第1期10-24,共15页
WiFi-based human activity recognition(HAR)provides a non-intrusive approach for ubiquitous monitoring;however,achieving both high accuracy and robustness simultaneously remains a significant challenge.This paper propo... WiFi-based human activity recognition(HAR)provides a non-intrusive approach for ubiquitous monitoring;however,achieving both high accuracy and robustness simultaneously remains a significant challenge.This paper proposes a Convolutional Neural Network with Enhanced Convolutional Block Attention Module(CNN-ECBAM)framework.The approach systematically converts raw Channel State Information(CSI)into pseudo-color images,effectively preserving essential signal characteristics for deep neural network processing.The core innovation is an Enhanced Convolutional Block Attention Module(ECBAM),tailored to CSI data characteristics,which integrates Efficient Channel Attention(ECA)and Multi-Scale Spatial Attention(MSSA).By employing learnable adaptive fusion weights,it achieves dynamic synergy between channel and spatial features,enabling the network to capture highly discriminative spatiotemporal patterns.The ECBAM module is integrated into a unified Convolutional Neural Network(CNN)to form the overall CNN-ECBAM model.Experimental results on the UT-HAR and NTU-Fi_HAR datasets demonstrate that CNN-ECBAM achieves competitive performance in recognition accuracy and outperforms mainstream baseline models.Specifically,it attains 99.20%accuracy on UT-HAR(surpassing ResNet-18 at 98.60%)and achieves 100%accuracy on NTU-Fi_HAR(exceeding GAF-CNN at 99.62%).These results validate the effectiveness of the proposed method for high-precision and reliable WiFi-based HAR. 展开更多
关键词 human activity recognition deep learning channel state information Enhanced Convolutional Block Attention module(ECBAM) pseudo-color images
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Remaining Life Prediction Method for Photovoltaic Modules Based on Two-Stage Wiener Process 被引量:1
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作者 Jie Lin Hongchi Shen +1 位作者 Tingting Pei Yan Wu 《Energy Engineering》 EI 2025年第1期331-347,共17页
Photovoltaic (PV) modules, as essential components of solar power generation systems, significantly influence unitpower generation costs.The service life of these modules directly affects these costs. Over time, the p... Photovoltaic (PV) modules, as essential components of solar power generation systems, significantly influence unitpower generation costs.The service life of these modules directly affects these costs. Over time, the performanceof PV modules gradually declines due to internal degradation and external environmental factors.This cumulativedegradation impacts the overall reliability of photovoltaic power generation. This study addresses the complexdegradation process of PV modules by developing a two-stage Wiener process model. This approach accountsfor the distinct phases of degradation resulting from module aging and environmental influences. A powerdegradation model based on the two-stage Wiener process is constructed to describe individual differences inmodule degradation processes. To estimate the model parameters, a combination of the Expectation-Maximization(EM) algorithm and the Bayesian method is employed. Furthermore, the Schwarz Information Criterion (SIC) isutilized to identify critical change points in PV module degradation trajectories. To validate the universality andeffectiveness of the proposed method, a comparative analysis is conducted against other established life predictiontechniques for PV modules. 展开更多
关键词 Photovoltaic modules DEGRADATION stochastic processes lifetime prediction
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基于CBM-CFS3模型的不同采伐情景下马尾松人工林生态系统碳动态
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作者 朱粟锋 勾蒙蒙 +4 位作者 赵海平 刘常富 简尊吉 朱建华 肖文发 《林业科学》 北大核心 2025年第12期24-33,共10页
【目的】厘清采伐干扰下人工林碳库变化以及碳收支响应规律,为人工林木材生产与碳汇功能双提升的科学经营提供新的思路和视角。【方法】以我国亚热带地区马尾松人工林为研究对象,利用经参数本地化改进的CBM-CFS3模型模拟马尾松人工林碳... 【目的】厘清采伐干扰下人工林碳库变化以及碳收支响应规律,为人工林木材生产与碳汇功能双提升的科学经营提供新的思路和视角。【方法】以我国亚热带地区马尾松人工林为研究对象,利用经参数本地化改进的CBM-CFS3模型模拟马尾松人工林碳库组分差异以及不同采伐强度下(0、10%、25%和40%)未来41年碳汇变化。【结果】各类马尾松人工林的Richards方程拟合效果良好(R^(2)≥0.57,MAE≤15.54 m^(3)∙hm^(-2),RMSE≤17.50 m^(3)∙hm^(-2)),能够较为广泛地表征区域内马尾松生长态势。2018年马尾松人工林生态系统平均碳密度为122.97 Mg∙hm^(-2)(植被层34.79 Mg∙hm^(-2)、死亡有机质32.00 Mg∙hm^(-2)、土壤56.18 Mg∙hm^(-2)),其中植被层各碳库的碳密度整体呈现出干>根>枝>叶的排序。在采伐周期为15年的各类经营情景下,2019—2060年马尾松人工林所能达到的碳密度最大值和固碳速率最大值均为10%采伐强度>0采伐强度>25%采伐强度>40%采伐强度;15年采伐周期+10%采伐强度情景的最大碳密度和最大固碳速率分别可达194.73 Mg∙hm^(-2)和2.30 Mg∙hm^(-2)a^(-1),到2060年时,我国马尾松人工林碳储量最高可达494.17 Tg,其中生物量碳储量可达217.94 Tg。【结论】CBM-CFS3模型经参数本地化改进后可对马尾松人工林各碳库分布及碳密度变化进行良好模拟。10%采伐强度情景下,马尾松人工林具备最大的固碳潜力,能够兼顾木材生产和碳汇功能。建议在人工林经营中采取适度的采伐强度和周期,以此帮助快速更新老化林分,在保证高出材率的同时提高碳固存能力。 展开更多
关键词 cbm-CFS3模型 马尾松人工林 采伐经营 生态系统 碳汇
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A review of encapsulation methods and geometric improvements of perovskite solar cells and modules for mass production and commercialization 被引量:1
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作者 Wending Yang Yubo Zhang +2 位作者 Chengchao Xiao Jingxuan Yang Tailong Shi 《Nano Materials Science》 2025年第6期790-809,共20页
Owing to the outstanding optoelectronic properties of perovskite materials,perovskite solar cells(PSCs)have been widely studied by academic organizations and industry corporations,with great potential to become the ne... Owing to the outstanding optoelectronic properties of perovskite materials,perovskite solar cells(PSCs)have been widely studied by academic organizations and industry corporations,with great potential to become the next-generation commercial solar cells.However,critical challenges remain in preserving high efficiency practical large-scale commercialized PSCs:a)the long-term stability of the cell materials and devices,b)lead leakage,and c)methods to scale the cells for larger area applications.This paper summarizes the prior-art strategies to address the above challenges,including the latest studies on the traditional glass-glass and thin-film encapsulation methods to better improve the reliability of PSCs,new technologies for preventing lead leakage,and geometric improvement strategies to enhance the reliability,efficiency,and performance of perovskite solar modules(PSMs).Through these strategies,the device achieved enhanced performance in long-term stability tests.The encapsulation resulted in a high lead leakage inhibition rate of up to 99%,and the PSMs possessed a geometric fill factor of 99.6%and a power conversion efficiency(PCE)of 20.7%.The dramatic improvement of efficiency and reliability of perovskite solar cells and modules indicate the great potential for mass production and commer-cialization of perovskite solar applications in the near future. 展开更多
关键词 Perovskite solar modules ENCAPSULATION Geometric improvement Stability COMMERCIALIZATION
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A Two-Stage Wiener Degradation Model-Based Approach for Visual Maintenance of Photovoltaic Modules 被引量:1
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作者 Jie Lin Hongchi Shen +1 位作者 Tingting Pei Yan Wu 《Energy Engineering》 2025年第6期2449-2463,共15页
This study proposes a novel visual maintenance method for photovoltaic(PV)modules based on a two-stage Wiener degradation model,addressing the limitations of traditional PV maintenance strategies that often result in ... This study proposes a novel visual maintenance method for photovoltaic(PV)modules based on a two-stage Wiener degradation model,addressing the limitations of traditional PV maintenance strategies that often result in insufficient or excessive maintenance.The approach begins by constructing a two-stage Wiener process performance degradation model and a remaining life prediction model under perfect maintenance conditions using historical degradation data of PV modules.This enables accurate determination of the optimal timing for postfailure corrective maintenance.To optimize the maintenance strategy,the study establishes a comprehensive cost model aimed at minimizing the long-term average cost rate.The model considers multiple cost factors,including inspection costs,preventive maintenance costs,restorative maintenance costs,and penalty costs associated with delayed fault detection.Through this optimization framework,the method determines both the optimal maintenance threshold and the ideal timing for predictive maintenance actions.Comparative analysis demonstrates that the twostage Wiener model provides superior fitting performance compared to conventional linear and nonlinear degradation models.When evaluated against traditional maintenance approaches,including Wiener process-based corrective maintenance strategies and static periodic maintenance strategies,the proposed method demonstrates significant advantages in reducing overall operational costs while extending the effective service life of PV components.The method achieves these improvements through effective coordination between reliability optimization and economic benefit maximization,leading to enhanced power generation performance.These results indicate that the proposed approach offers a more balanced and efficient solution for PV system maintenance. 展开更多
关键词 Photovoltaic module remaining life maintenance strategy Wiener modeling
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CBM聘任格罗宁根大学Henk.J.Busscher教授与南开大学史林启教授为副主编
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《中国肿瘤临床》 北大核心 2025年第12期646-646,共1页
近日,Cancer Biology&Medicine(CBM)编委学术交流会于天津医科大学肿瘤医院成功举行,荷兰格罗宁根大学Henk.J.Busscher教授与南开大学史林启教授来访。Busscher教授是生物材料领域国际知名专家,深耕细菌生物被膜及细胞与生物材料界... 近日,Cancer Biology&Medicine(CBM)编委学术交流会于天津医科大学肿瘤医院成功举行,荷兰格罗宁根大学Henk.J.Busscher教授与南开大学史林启教授来访。Busscher教授是生物材料领域国际知名专家,深耕细菌生物被膜及细胞与生物材料界面相互作用的研究,其成果广泛应用于生物材料抗菌及细菌黏附设计。史林启教授是聚合物化学和纳米技术领域领军专家,带领团队在抗肿瘤纳米材料取得了突破性进展,为肿瘤治疗带来了新的希望。 展开更多
关键词 副主编 教授 南开大学 史林启 cbm
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EL-DenseNet:Mushroom Recognition Based on Erasing Module Using DenseNet
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作者 WANG Yaojun ZHAO Weiting +1 位作者 BIE Yuhui JIA Lu 《农业机械学报》 北大核心 2025年第9期628-637,共10页
Target occlusion poses a significant challenge in computer vision,particularly in agricultural applications,where occlusion of crops can obscure key features and impair the model’s recognition performance.To address ... Target occlusion poses a significant challenge in computer vision,particularly in agricultural applications,where occlusion of crops can obscure key features and impair the model’s recognition performance.To address this challenge,a mushroom recognition method was proposed based on an erase module integrated into the EL-DenseNet model.EL-DenseNet,an extension of DenseNet,incorporated an erase attention module designed to enhance sensitivity to visible features.The erase module helped eliminate complex backgrounds and irrelevant information,allowing the mushroom body to be preserved and increasing recognition accuracy in cluttered environments.Considering the difficulty in distinguishing similar mushroom species,label smoothing regularization was employed to mitigate mislabeling errors that commonly arose from human observers.This strategy converted hard labels into soft labels during training,reducing the model’s overreliance on noisy labels and improving its generalization ability.Experimental results showed that the proposed EL-DenseNet,when combined with transfer learning,achieved a recognition accuracy of 96.7%for mushrooms in occluded and complex backgrounds.Compared with the original DenseNet and other classic models,this approach demonstrated superior accuracy and robustness,providing a promising solution for intelligent mushroom recognition. 展开更多
关键词 mushroom recognition erase module label smoothing DenseNet
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糖基化修饰对CBM与纤维素及木质素结合的影响
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作者 赖子健 巩金媛 +7 位作者 李鑫 刘文强 李耀豪 陈保权 秦春君 马博 谭忠平 尹健 《食品与生物技术学报》 北大核心 2025年第3期75-81,共7页
【目的】探索糖基化修饰是否会对碳水化合物结合模块(CBM)与纤维素及木质素的结合产生差异性影响。【方法】通过化学合成在3个糖基化位点(Thr1、Ser3和Ser14)上制备了4种具有不同糖基化模式的糖基化异型体——CBM000、CBM010、CBM002、C... 【目的】探索糖基化修饰是否会对碳水化合物结合模块(CBM)与纤维素及木质素的结合产生差异性影响。【方法】通过化学合成在3个糖基化位点(Thr1、Ser3和Ser14)上制备了4种具有不同糖基化模式的糖基化异型体——CBM000、CBM010、CBM002、CBM122,并比较它们在4、35、45、60、70℃与纤维素及木质素结合能力的差异。【结果】不同温度下,糖基化对CBM与纤维素及木质素结合的影响不同。CBM000在45℃对纤维素具有更好的结合选择性,CBM010在4℃和45℃对纤维素具有更好的结合选择性,CBM002在60℃对纤维素具有更好的结合选择性,CBM122在45℃对纤维素具有更好的结合选择性。【结论】升高温度可提升CBM的底物结合选择性,表明通过糖基化修饰能够增强CBM在高温下与底物结合的能力。 展开更多
关键词 碳水化合物结合模块 糖基化 纤维素 木质素
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汽轮机叶片裂纹的AE监测与CBM策略优化
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作者 宋玉杰 赵辉 李晓辉 《设备管理与维修》 2025年第21期156-160,共5页
汽轮机叶片裂纹是影响机组安全运行的关键因素。传统监测方法存在滞后性,AE技术因其对材料内部损伤的敏感性成为早期裂纹监测的有效手段。深入探讨AE监测技术原理,设计一套针对汽轮机叶片裂纹的在线监测系统,并结合实际案例,构建基于AE... 汽轮机叶片裂纹是影响机组安全运行的关键因素。传统监测方法存在滞后性,AE技术因其对材料内部损伤的敏感性成为早期裂纹监测的有效手段。深入探讨AE监测技术原理,设计一套针对汽轮机叶片裂纹的在线监测系统,并结合实际案例,构建基于AE特征参数的状态评估模型与检修决策优化流程。研究表明,基于AE技术的CBM策略可显著提升裂纹检出率与检修经济性,对保障汽轮机安全经济运行具有重要价值。 展开更多
关键词 汽轮机 叶片裂纹 AE监测 cbm
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Hydrophobic surface release and energy-level alignment of PTAA enables stable flexible perovskite solar modules
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作者 Hua Zhong Jianxing Xia +2 位作者 Hao Tian Chuanxiao Xiao Fei Zhang 《Journal of Energy Chemistry》 2025年第10期448-454,共7页
The fabrication of efficient and stable flexible perovskite solar modules(F-PSMs)using poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine](PTAA)remains a significant challenge due to its hydrophobic properties and the mis... The fabrication of efficient and stable flexible perovskite solar modules(F-PSMs)using poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine](PTAA)remains a significant challenge due to its hydrophobic properties and the mismatch in interface energy-level alignment.Here,we introduced[2-(3,6-dimethoxy-9H-carba zol-9-yl)ethyl]phosphonic acid(MeO-2PACz)to modify the PTAA layer,which effectively suppressed surface potential fluctuations and aligned energy levels at the interface of PTAA/perovskite.Additionally,MeO-2PACz enhanced the hydrophilicity of PTAA,facilitating the fabrication of dense,uniform,and pinhole-free perovskite films on large-area flexible substrates.As a result,we achieved an F-PSM with a power conversion efficiency(PCE)of 16.6% and an aperture area of 64 cm^(2),which is the highest reported value among F-PSMs with an active area exceeding 35 cm^(2)based on PTAA.Moreover,the encapsulated module demonstrated outstanding long-term operational stability,retaining 90.2% of its initial efficiency after 1000 bending cycles(5 mm radius),87.2% after 1000 h of continuous illumination,and 80.3% under combined thermal and humid conditions(85℃ and 85% relative humidity),representing one of the most stable F-PSMs reported to date. 展开更多
关键词 FLEXIBLE Perovskite solar modules STABILITY
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Simple Yetter-Drinfeld Modules over a Non-Pointed Hopf Algebra
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作者 Ruifang YANG Shilin YANG 《Journal of Mathematical Research with Applications》 2025年第6期716-734,共19页
Let D(n)be the finite dimensional non-pointed and non-semisimple Hopf algebra,which is a quotient of a prime Hopf algebras of GK-dimension one for an odd number n>1.In this paper,we investigate the structure of Yet... Let D(n)be the finite dimensional non-pointed and non-semisimple Hopf algebra,which is a quotient of a prime Hopf algebras of GK-dimension one for an odd number n>1.In this paper,we investigate the structure of Yetter-Drinfeld simple modules over D(n)and give iso-classes of them. 展开更多
关键词 Hopf algebra Yetter-Drinfeld module Nichols algebra
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Two-tailed modification module tuned steric-hindrance effect enabling high therapeutic efficacy of paclitaxel prodrug nanoassemblies
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作者 Wenfeng Zang Yixin Sun +9 位作者 Jingyi Zhang Yanzhong Hao Qianhui Jin Hongying Xiao Zuo Zhang Xianbao Shi Jin Sun Zhonggui He Cong Luo Bingjun Sun 《Chinese Chemical Letters》 2025年第5期453-459,共7页
Self-assembled prodrug nanomedicine has emerged as an advanced platform for antitumor therapy,mainly comprise drug modules,response modules and modification modules.However,existing studies usually compare the differe... Self-assembled prodrug nanomedicine has emerged as an advanced platform for antitumor therapy,mainly comprise drug modules,response modules and modification modules.However,existing studies usually compare the differences between single types of modification modules,neglecting the impact of steric-hindrance effect caused by chemical structure.Herein,single-tailed modification module with low-steric-hindrance effect and two-tailed modification module with high-steric-hindrance effect were selected to construct paclitaxel prodrugs(P-LA_(C18)and P-BAC18),and the in-depth insights of the sterichindrance effect on prodrug nanoassemblies were explored.Notably,the size stability of the two-tailed prodrugs was enhanced due to improved intermolecular interactions and steric hindrance.Single-tailed prodrug nanoassemblies were more susceptible to attack by redox agents,showing faster drug release and stronger antitumor efficacy,but with poorer safety.In contrast,two-tailed prodrug nanoassemblies exhibited significant advantages in terms of pharmacokinetics,tumor accumulation and safety due to the good size stability,thus ensuring equivalent antitumor efficacy at tolerance dose.These findings highlighted the critical role of steric-hindrance effect of the modification module in regulating the structureactivity relationship of prodrug nanoassemblies and proposed new perspectives into the precise design of self-assembled prodrugs for high-performance cancer therapeutics. 展开更多
关键词 Prodrug nanoassemblies Two-tailed modification module Steric-hindrance PACLITAXEL Anticancer
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Wood-derived catalysts for green and stable Fenton-like chemistry:From basic mechanisms to catalytic modules and future inspiration
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作者 Xiaoyun Lei Hanghang Zhao +2 位作者 Chao Bai Longlong Geng Xing Xu 《Chinese Chemical Letters》 2025年第10期212-225,共14页
Most carbon-based catalysts utilized in Fenton-like systems face challenges such as structural instability,susceptibility to deactivation,and a tendency to disperse during operation.Wood-derived catalysts have garnere... Most carbon-based catalysts utilized in Fenton-like systems face challenges such as structural instability,susceptibility to deactivation,and a tendency to disperse during operation.Wood-derived catalysts have garnered considerable attention due to their well-defined structures,extensive pipeline networks,superior mechanical strength,and adaptability for device customization.However,there remains a paucity of research that systematically summarizes Fenton-like systems based on wood-derived catalysts.In this review,we first summarize the structural designs of wood-derived catalysts based on nano-metal sites and single-atom sites,while also outlining their advantages and limitations applied in Fenton-like systems.Furthermore,we evaluate catalytic modules of wood-derived catalysts for scale-up and continuous Fenton-like systems.Additionally,wood-inspired catalytic materials utilizing commercial textures and their applications in Fenton-like processes are also discussed.This paper aims to comprehensively explore the fundamental mechanisms(e.g.,characteristics of catalytic sites,catalytic performance,and mechanisms)of wood-based catalysts in Fenton-like chemistry,as well as their equipment designs and application scenarios,as well as providing the insights into future developments. 展开更多
关键词 Wood-derive catalysts Nano-metal Fenton-like chemistry Scale-up application Catalytic modules
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