The landscape of tumor microenvironment(TME)research has un-dergone rapid transformation over the past decade.1,2 As we deepen our understanding of the TME’s role in cancer progression,immune response modulation,and ...The landscape of tumor microenvironment(TME)research has un-dergone rapid transformation over the past decade.1,2 As we deepen our understanding of the TME’s role in cancer progression,immune response modulation,and therapeutic efficacy,this special issue,“Tumor Microen-vironment and Immunotherapy:From Bench to Bedside,”brings forth the latest breakthroughs in these domains.It highlights the interplay be-tween the TME,immune system dynamics,and cancer therapies,with a particular emphasis on precision medicine and the development of targeted treatments.展开更多
Combining bright-feld and edge-enhanced imaging affords an effective avenue for extracting complex morphological information from objects,which is particularly beneficial for biological imaging.Multiplexing metalenses...Combining bright-feld and edge-enhanced imaging affords an effective avenue for extracting complex morphological information from objects,which is particularly beneficial for biological imaging.Multiplexing metalenses present promising candidates for achieving this functionality.However,current multiplexing meta-lenses lack spectral modulation,and crosstalk between different wavelengths hampers the imaging quality,especilly for biological samples requiring precise wavelength specificity.Here,we experimentally demonstrate the nonlocal Huygens'meta-lens for high-quality-factor spin-multiplexing imaging.Quasi-bound states in the continuum(q-BlCs)are excited to provide a high quality factor of 90 and incident-angle dependence.The generalized Kerker condition,driven by Fano-like interactions between q-BIC and in-plane Mie resonances,breaks the radiation symmetry,resulting in a transmission peak with a geometric phase for polarization-converted light,while unconverted light exhibits a transmission dip without a geometric phase.Enhanced polarization conversion efficiency of 65%is achieved,accompanied by a minimal unconverted value,surpassing the theoretical limit of traditional thin nonlocal metasurfaces.Leveraging these effects,the output polarization-converted state exhibits an efficient wavelengthselective focusing phase profle.The unconverted counterpart serves as an effective spatial frequency filter based on incident-angular dispersion,passing high-frequency edge details.Bright-field imaging and edge detection are thus presented under two output spin states.This work provides a versatile framework for nonlocal metasurfaces,boosting biomedical imaging and sensing applications.展开更多
Natural perceptual systems,shaped by millions of years of evolution,exhibit unparalleled environmental adaptability and energy-efficient information processing that surpass existing engineering technologies[[1],[2],[3...Natural perceptual systems,shaped by millions of years of evolution,exhibit unparalleled environmental adaptability and energy-efficient information processing that surpass existing engineering technologies[[1],[2],[3]].Particularly,the avian visual system of raptors-especially eagles has emerged as a paradigm for bioinspired optoelectronics,owing to its integrated multispectral sensing,dynamic range modulation,and hierarchical neural processing[4].展开更多
基金partially supported by grants from the Non-communicable Chronic Diseases-National Science and Technology Major Project(grant num-ber:2023ZD0510300)the National Natural Science Foundation of China(grant numbers:82403377,82473192).
文摘The landscape of tumor microenvironment(TME)research has un-dergone rapid transformation over the past decade.1,2 As we deepen our understanding of the TME’s role in cancer progression,immune response modulation,and therapeutic efficacy,this special issue,“Tumor Microen-vironment and Immunotherapy:From Bench to Bedside,”brings forth the latest breakthroughs in these domains.It highlights the interplay be-tween the TME,immune system dynamics,and cancer therapies,with a particular emphasis on precision medicine and the development of targeted treatments.
基金supported by the University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region,China[Project No.AoE/P-502/20,CRF Project:C5031-22G,GRF Project:CityU15303521,CityU11305223,CityU11300224]City University of Hong Kong[Project No.9380131 and 7005867]+3 种基金National Natural Science Foundation of China[Grant No.62375232]S.X.acknowledges financial support from National Natural Science Foundation of China(Grant Nos.62125501,and 6233000076)Fundamental Research Funds for the Central Universities(Grant No.2022FRRK030004)Shenzhen Fundamental Research Projects(Grant Nos.JCYJ20220818102218040).
文摘Combining bright-feld and edge-enhanced imaging affords an effective avenue for extracting complex morphological information from objects,which is particularly beneficial for biological imaging.Multiplexing metalenses present promising candidates for achieving this functionality.However,current multiplexing meta-lenses lack spectral modulation,and crosstalk between different wavelengths hampers the imaging quality,especilly for biological samples requiring precise wavelength specificity.Here,we experimentally demonstrate the nonlocal Huygens'meta-lens for high-quality-factor spin-multiplexing imaging.Quasi-bound states in the continuum(q-BlCs)are excited to provide a high quality factor of 90 and incident-angle dependence.The generalized Kerker condition,driven by Fano-like interactions between q-BIC and in-plane Mie resonances,breaks the radiation symmetry,resulting in a transmission peak with a geometric phase for polarization-converted light,while unconverted light exhibits a transmission dip without a geometric phase.Enhanced polarization conversion efficiency of 65%is achieved,accompanied by a minimal unconverted value,surpassing the theoretical limit of traditional thin nonlocal metasurfaces.Leveraging these effects,the output polarization-converted state exhibits an efficient wavelengthselective focusing phase profle.The unconverted counterpart serves as an effective spatial frequency filter based on incident-angular dispersion,passing high-frequency edge details.Bright-field imaging and edge detection are thus presented under two output spin states.This work provides a versatile framework for nonlocal metasurfaces,boosting biomedical imaging and sensing applications.
基金supported by the National Key Research and Development Program of China(2021YFA0717900)the National Natural Science Foundation of China(52273190 and 52121002).
文摘Natural perceptual systems,shaped by millions of years of evolution,exhibit unparalleled environmental adaptability and energy-efficient information processing that surpass existing engineering technologies[[1],[2],[3]].Particularly,the avian visual system of raptors-especially eagles has emerged as a paradigm for bioinspired optoelectronics,owing to its integrated multispectral sensing,dynamic range modulation,and hierarchical neural processing[4].
