Steel slag(SS)accumulates unavoidably due to its complex and unstable composition,high production volumes,and limited value-added resource utilization.Single or multiple interface modifiers were proposed to enhance th...Steel slag(SS)accumulates unavoidably due to its complex and unstable composition,high production volumes,and limited value-added resource utilization.Single or multiple interface modifiers were proposed to enhance the properties of SS through high-speed dispersion,transforming its inherent hydrophilic and oleophobic characteristics into hydrophily and lipophilicity.The modification effects were innovatively assessed by observing the color changes of modified steel slag solutions following the dissolution-settlement equilibrium constant.This approach avoided human-induced errors and improved estimated accuracy in conformance with conventional methods such as oil absorption value,activation index,sedimentation volume,and lipophilicity.The hydrolysis of 3-aminopropyltriethoxysilane(KH)generated–Si(OH)_(3)structure to form hydrogen or covalent bonds with active substances(OH groups)from SS.Concurrently,SS underwent encapsulation via Si–O–Si structure resulting from the dehydration of–Si(OH)_(3).The stearic acid coupling agent(SA),aluminate coupling agent(AC),and titanate coupling agent(TN)underwent chemical reactions with Ca(OH)_(2),Al(OH)_(3),and CaCO_(3)in SS.The acidic SA primarily created stable chemical bonds and acted as a supplement due to its package,reducing surface activity and hydrophilicity while enhancing lipophilicity.Specifically,the optimal modification effect was obtained at 3 wt.%SA.Consequently,3 wt.%SA was established as the benchmark for multiple modifiers and the most effective combination was 3 wt.%SA and 3 wt.%AC.Compared with a single interface modifier,SA corroded the SS surface to provide numerous active sites for further modification by KH,AC,or TN,resulting in a more densely packed structure.In addition,more organic groups on SS prevent the proximity of other particles from agglomerating to achieve dispersion and a synergistic modification,laying a theoretical foundation of SS in a new pathway for organic composite materials.展开更多
目的:基于“湿热伤肾”学说探究加味二妙丸改善糖尿病肾脏疾病难治性蛋白尿的疗效和作用机制。方法:选取2022年1月—2025年1月于南京大学医学院附属鼓楼医院中医科以及肾内科的糖尿病肾脏疾病患者126例。采用随机数字表法分为治疗组和...目的:基于“湿热伤肾”学说探究加味二妙丸改善糖尿病肾脏疾病难治性蛋白尿的疗效和作用机制。方法:选取2022年1月—2025年1月于南京大学医学院附属鼓楼医院中医科以及肾内科的糖尿病肾脏疾病患者126例。采用随机数字表法分为治疗组和对照组,每组63例。对照组给予常规基础治疗。治疗组在常规基础治疗上应用加味二妙丸治疗。分别于入组当天及治疗8周,评估患者中医证候积分情况[口渴多饮、肢体浮肿、口中黏腻、脘腹胀满]、检测尿蛋白谱指标[24 h尿蛋白(24 h UPro)、尿白蛋白(UAlb)、尿肾损伤分子-1(UKim-1)、尿N-乙酰-β-D-葡萄糖苷酶(UNAG)]、代谢组学指标[棕榈酸、左旋肉碱、磷脂酰胆碱(PC)、二酰甘油(Dg)]、肾功能指标[血肌酐(Scr)、血尿素氮(BUN)]、安全性指标[红细胞(RBC)、丙氨酸氨基转移酶(ALT)、白蛋白(Alb)、糖化血红蛋白(HbA1c)]水平。对比两组临床疗效。结果:治疗后,与对照组比较,治疗组口渴多饮、肢体浮肿、口中黏腻、脘腹胀满积分、24 h UPro、UAlb、UKim-1、UNAG、棕榈酸、Scr、BUN水平均降低(P<0.05,P<0.01),左旋肉碱、PC、Dg水平升高(P<0.05,P<0.01)。与对照组比较,治疗组总有效率升高(P<0.01)。结论:基于“湿热伤肾”学说在常规基础治疗上,应用加味二妙丸首次在单中心随机对照研究中证实其可显著改善糖尿病肾脏疾病难治性蛋白尿,调节代谢组学指标并保护肾功能,且安全性高;棕榈酸、左旋肉碱、PC、Dg可能是加味二妙丸治疗糖尿病肾脏疾病难治性蛋白尿的药物靶标。展开更多
Wood-polymer composites (WPC) were prepared from wood fiber and four kinds of plastics such as PE, PS, ABS, and SAN. The effects of different modifiers on the mechanical properties of the composites were studied. The ...Wood-polymer composites (WPC) were prepared from wood fiber and four kinds of plastics such as PE, PS, ABS, and SAN. The effects of different modifiers on the mechanical properties of the composites were studied. The results showed modifiers could raise the bonding strength of wood fiber with polymer and improve the mechanical properties of the composites. Different modifiers had different effects on the properties of wood-polymer composites, and comparatively the modifier of isocyanate produced a better result. Wood-polymer composite takes not only the advantages of both wood fiber and polymer, but waterproof, dimensional stability and dynamic strength are also significantly improved. Key word Wood fiber - Thermoplastic polyester - Wood-polymer composites - Modifier - Mechanical properties CLC number TB332 Document code A Foundation item: This study was supported by the Harbin Technology Tackle Key Plan (Development Research of Wood-Polymer Composites with High Wood Matrix) and by Heilongjing Nature Science Fund (Composite Mechanism Study of the Wood Polymer).Biography: XU Min (1963-), Female, Associate professor in Material Science and Engineering College, Northeast Forestry University, Harbin 150040, P. R. China.Responsible editor: Chai Ruihai展开更多
基金supported by the National Natural Science Foundation of China(U23A20605)Anhui Graduate Innovation and Entrepreneurship Practice Project(2022cxcysj090)+2 种基金China Baowu Low Carbon Metallurgy Innovation Foundation(BWLCF202202)the University Synergy Innovation Program of Anhui Province(GXXT-2020-072)the Outstanding Youth Fund of Anhui Province(2208085J19).
文摘Steel slag(SS)accumulates unavoidably due to its complex and unstable composition,high production volumes,and limited value-added resource utilization.Single or multiple interface modifiers were proposed to enhance the properties of SS through high-speed dispersion,transforming its inherent hydrophilic and oleophobic characteristics into hydrophily and lipophilicity.The modification effects were innovatively assessed by observing the color changes of modified steel slag solutions following the dissolution-settlement equilibrium constant.This approach avoided human-induced errors and improved estimated accuracy in conformance with conventional methods such as oil absorption value,activation index,sedimentation volume,and lipophilicity.The hydrolysis of 3-aminopropyltriethoxysilane(KH)generated–Si(OH)_(3)structure to form hydrogen or covalent bonds with active substances(OH groups)from SS.Concurrently,SS underwent encapsulation via Si–O–Si structure resulting from the dehydration of–Si(OH)_(3).The stearic acid coupling agent(SA),aluminate coupling agent(AC),and titanate coupling agent(TN)underwent chemical reactions with Ca(OH)_(2),Al(OH)_(3),and CaCO_(3)in SS.The acidic SA primarily created stable chemical bonds and acted as a supplement due to its package,reducing surface activity and hydrophilicity while enhancing lipophilicity.Specifically,the optimal modification effect was obtained at 3 wt.%SA.Consequently,3 wt.%SA was established as the benchmark for multiple modifiers and the most effective combination was 3 wt.%SA and 3 wt.%AC.Compared with a single interface modifier,SA corroded the SS surface to provide numerous active sites for further modification by KH,AC,or TN,resulting in a more densely packed structure.In addition,more organic groups on SS prevent the proximity of other particles from agglomerating to achieve dispersion and a synergistic modification,laying a theoretical foundation of SS in a new pathway for organic composite materials.
文摘目的:基于“湿热伤肾”学说探究加味二妙丸改善糖尿病肾脏疾病难治性蛋白尿的疗效和作用机制。方法:选取2022年1月—2025年1月于南京大学医学院附属鼓楼医院中医科以及肾内科的糖尿病肾脏疾病患者126例。采用随机数字表法分为治疗组和对照组,每组63例。对照组给予常规基础治疗。治疗组在常规基础治疗上应用加味二妙丸治疗。分别于入组当天及治疗8周,评估患者中医证候积分情况[口渴多饮、肢体浮肿、口中黏腻、脘腹胀满]、检测尿蛋白谱指标[24 h尿蛋白(24 h UPro)、尿白蛋白(UAlb)、尿肾损伤分子-1(UKim-1)、尿N-乙酰-β-D-葡萄糖苷酶(UNAG)]、代谢组学指标[棕榈酸、左旋肉碱、磷脂酰胆碱(PC)、二酰甘油(Dg)]、肾功能指标[血肌酐(Scr)、血尿素氮(BUN)]、安全性指标[红细胞(RBC)、丙氨酸氨基转移酶(ALT)、白蛋白(Alb)、糖化血红蛋白(HbA1c)]水平。对比两组临床疗效。结果:治疗后,与对照组比较,治疗组口渴多饮、肢体浮肿、口中黏腻、脘腹胀满积分、24 h UPro、UAlb、UKim-1、UNAG、棕榈酸、Scr、BUN水平均降低(P<0.05,P<0.01),左旋肉碱、PC、Dg水平升高(P<0.05,P<0.01)。与对照组比较,治疗组总有效率升高(P<0.01)。结论:基于“湿热伤肾”学说在常规基础治疗上,应用加味二妙丸首次在单中心随机对照研究中证实其可显著改善糖尿病肾脏疾病难治性蛋白尿,调节代谢组学指标并保护肾功能,且安全性高;棕榈酸、左旋肉碱、PC、Dg可能是加味二妙丸治疗糖尿病肾脏疾病难治性蛋白尿的药物靶标。
基金Supported by the Harbin Technology Tackle Key Plan (Development Research of Wood-Polymer Composites with High Wood Matrix) and by Heilongjing Nature Science Fund (Composite Mechanism Study of the Wood Polymer).
文摘Wood-polymer composites (WPC) were prepared from wood fiber and four kinds of plastics such as PE, PS, ABS, and SAN. The effects of different modifiers on the mechanical properties of the composites were studied. The results showed modifiers could raise the bonding strength of wood fiber with polymer and improve the mechanical properties of the composites. Different modifiers had different effects on the properties of wood-polymer composites, and comparatively the modifier of isocyanate produced a better result. Wood-polymer composite takes not only the advantages of both wood fiber and polymer, but waterproof, dimensional stability and dynamic strength are also significantly improved. Key word Wood fiber - Thermoplastic polyester - Wood-polymer composites - Modifier - Mechanical properties CLC number TB332 Document code A Foundation item: This study was supported by the Harbin Technology Tackle Key Plan (Development Research of Wood-Polymer Composites with High Wood Matrix) and by Heilongjing Nature Science Fund (Composite Mechanism Study of the Wood Polymer).Biography: XU Min (1963-), Female, Associate professor in Material Science and Engineering College, Northeast Forestry University, Harbin 150040, P. R. China.Responsible editor: Chai Ruihai
