Summary: Occlusal-maxillo-facial structural change of crossbite malocclusion after orthodontic therapy by modified ACTIVATOR appliance was investigated. Eighty crossbite cases of deciduous dentition and mixed dentitio...Summary: Occlusal-maxillo-facial structural change of crossbite malocclusion after orthodontic therapy by modified ACTIVATOR appliance was investigated. Eighty crossbite cases of deciduous dentition and mixed dentition were treated by modified ACTIVATOR. Through pre- and post-treatment analysis of stone model, Schuller's position X-ray and craniofaciometrics, the change in craniofacial length, width and height in early-phase crossbite malocclusion was studied. The results showed that there was no significant change in the width of maxillary and mandibular dental arch. Maxillary length and protrusion was increased significantly, upper incisors slopped labially. The lower incisors slopped lingually, mental angle decreased more severely. The lower and posterior facial height was increased to normal level.展开更多
Advanced oxidation processes are promising for degradation of the highly chemical stability and refractory methylisothiazolinone(MIT) bactericides in relevant industrial wastewater.In order to assemble a low cost and ...Advanced oxidation processes are promising for degradation of the highly chemical stability and refractory methylisothiazolinone(MIT) bactericides in relevant industrial wastewater.In order to assemble a low cost and high performance electrochemical oxidation system for wastewater treatment,granular active carbon(GAC) was decorated by doping Ce,Sn,Sb to synthesize Sn-Sb-Ce/GAC using sol-gel method as particle electrode filled into a three-dimensional(3D) electrochemical reactor.Scanning electron microscopy(SEM),energy-dispersive spectroscopy(EDS) and X-ray diffraction(XRD) experiments revealed that the Sn-Sb-Ce/GAC particle electrode crystal particles were compact and uniform,and the surface structure was improved.The ten cyclic experiments indicated that the Sn-Sb-Ce/GAC particle electrode had high stability and low dissolution of the loaded active substance.The degradation mechanism of MIT was studied under the optimal working conditions of 3D electrode system with GAC of 5 g/L,current density of 20 mA/cm^(2),initial pH 5,electrolyte concentration of Na_(2)SO_(4)0.02 mol/L and reaction time of 120 min.The indirect electrochemical degradation of MIT was dominated by active substance pathway that active chlorine rather than free radicals(·OH) played the main role.Comparing with conventional two-dimensional(2D) electrode system,the 3D electrochemical system has larger active electrode area,higher treatment efficiency and lower energy consumption than the former.The 3D electrochemical system could remove 96.5% of MIT from the actual high-salt reverse osmosis concentrate wastewater in 30 min.It has a certain removal effect on UV_(254)in wastewater,but has a better removal effect on fluorescent substances.This study proposed a new strategy to develop transition metal and rare earth metal particle electrodes using carbon-based materials for high efficient electrocatalytic oxidation in the electrochemical treatment system.展开更多
Activated carbon （AC） was modified by tri-butyl phosphate （TBP） for selectively extracting scandium from red mud and characterized by BET （Brunauer-Emmett-Teller） surface area. The modified AC had a preferential...Activated carbon （AC） was modified by tri-butyl phosphate （TBP） for selectively extracting scandium from red mud and characterized by BET （Brunauer-Emmett-Teller） surface area. The modified AC had a preferential adsorption to scandium. The influences of adsorbent dos- age, adsorption temperature, and time on adsorption capacity and selectivity to scandium were examined. An optimum adsorbent dosage （-6.25 g/L）, adsorption temperature （308 K）, and adsorption time （40 min） were figured out. A pseudo-second-order kinetics model was employed for describing the adsorption process of scandium.展开更多
The ubiquitous arsenic in groundwater poses a great risk to human health due to its environmental toxicity and carcinogenicity.In the present work,a new adsorbent,δ-MnO2 modified activated carbon,was prepared,and its...The ubiquitous arsenic in groundwater poses a great risk to human health due to its environmental toxicity and carcinogenicity.In the present work,a new adsorbent,δ-MnO2 modified activated carbon,was prepared,and its performance for the uptake of arsenate and arsenite species from aqueous solutions was investigated by batch experiments.Various techniques,including FESEM-EDX,p-XRD,XPS and BET surface area analysis,were employed to characterize the properties of the adsorbent and the arsenic adsorption mechanisms.The results showed thatδ-MnO2 covered on the surface and padded in the pores of the activated carbon.Adsorption kinetic studies revealed that approximately 90.1%and 76.8%of As(Ⅲ)and As(V),respectively,were removed by the adsorbent in the first 9 hr,and adsorption achieved equilibrium within 48 hr.The maximum adsorption capacities of As(V)and As(Ⅲ)at pH 4.0 calculated from Langmuir adsorption isotherms were 13.30 and 12.56 mg/g,respectively.The effect of pH on As(Ⅴ)and As(Ⅲ)removal was similar,and the removal efficiency significantly reduced with the increase of solution pH.Arsenite oxidation and adsorption kinetics showed that the As(Ⅴ)concentration in solution due to As(Ⅲ)oxidation and reductive dissolution of MnO2 increased rapidly during the first 12 min,and then gradually decreased.Based on the XPS analysis,nearly 93.3%of As(Ⅲ)had been oxidized to As(V)on the adsorbent surface and around 38.9%of Mn(Ⅳ)had been reduced to Mn(Ⅱ)after As(Ⅲ)adsorption.This approach provides a possible method for the purification of arsenic-contaminated groundwater.展开更多
By using potassium permanganate impregnation method,common activated carbon was processed in 0. 079 mol/L KMnO4 solution at 650℃ to obtain modified activated carbon loaded with manganese oxide,and then different quan...By using potassium permanganate impregnation method,common activated carbon was processed in 0. 079 mol/L KMnO4 solution at 650℃ to obtain modified activated carbon loaded with manganese oxide,and then different quantities of common activated carbon and modified activated carbon were used to adsorb 0. 3 mg/m^3 formaldehyde. The results showed that carbon and manganese atoms on the surface of modified activated carbon could adsorb formaldehyde,and the removal rate of 0. 3 mg/m^3 formaldehyde by 30 g of modified activated carbon reached 80%,increased one time compared with that by common activated carbon. Different amounts of activated carbon had various effects on the adsorption of formaldehyde,and the best usage of common activated carbon and modified activated carbon was 100 and 30 g respectively.展开更多
This article discussed the benzoic acid activated carbons which have changed the types and content of acid oxygen-function groups on the surface of activated carbons and their effect on the adsorption for Hg^0 in simu...This article discussed the benzoic acid activated carbons which have changed the types and content of acid oxygen-function groups on the surface of activated carbons and their effect on the adsorption for Hg^0 in simulated flue gas at 140 ℃. These surface acid oxygen function groups were identified by Boehm titration, Fourier transformation infrared spectrum, temperature programmed desorption and X-ray photoelectron spectroscopy. It indicates that the carboxyl, lactone and phenolic were formed when the benzoic acid is loaded on the surface of activated carbons. Among the surface acid oxygen function groups, the carboxyl groups enhance the adsorption capacities of Hg^0 for activated carbons to a greater extent.展开更多
The adsorption capacity of activated carbon modified with KMnO4(potassium permanganate)for Cr(VI)from aqueous solution was investigated.The modified activated carbon was characterized by SEM(scanning electron microsco...The adsorption capacity of activated carbon modified with KMnO4(potassium permanganate)for Cr(VI)from aqueous solution was investigated.The modified activated carbon was characterized by SEM(scanning electron microscopy),FT-IR(Fourier transform infrared spectrometer),and N2 adsorption/desorption tests.Adsorption of Cr(VI)from aqueous solution onto the activated carbon was investigated in a batch system.In the present study,the effect of various parameters such as pH,contact time and initial concentration on the adsorption capacity were determined by ICP-AES(inductively coupled plasma atomic emission spectrometry).The Cr(VI)adsorption on the activated carbon conforms to the Langmuir and Freundlich isothermal adsorption equation.The rates of adsorption were found to conform to pseudo-second order kinetic.The modified activated carbon can be an effective adsorbent for Cr(VI)from the aqueous solution.展开更多
Glacial lakes in the High Mountain Asia(HMA)are sensitive to global warming and can result in much more severe flood disasters than some largesized lakes.An accurate and robust method for the extraction of glacial lak...Glacial lakes in the High Mountain Asia(HMA)are sensitive to global warming and can result in much more severe flood disasters than some largesized lakes.An accurate and robust method for the extraction of glacial lakes is critical to effective management of these natural water resources.Conventional methods often have limitations in terms of low spectral contrast and heterogeneous backgrounds in an image.This study presents a robust and automated method for the yearly mapping of glacial lake over a large scale,which took advantage of the complementarity between the modified normalized difference water index(MNDWI)and the nonlocal active contour model,required only local homogeneity in reflectance features of lake.The cloud computing approach with the Google Earth Engine(GEE)platform was used to process the intensive amount of Landsat 8 images from 2015 (344 path/rows and approximately 7504 scenes).The experimental results were validated by very high resolution images from Chinese GaoFen-1 (GF-1) panchromatic multi-spectral(PMS)and appeared a general good agreement.This is the first time that information regarding the spatial distribution of glacial lakes over the HMA has been derived automatically within quite a short period of time.By integrating it with the relevant indices,it can also be applied to detect other land cover types such as snow or vegetation with improved accuracy.展开更多
In this context of Cellular and Molecular Immunology,Sharma and coworkers reported that the glucose transporter Glut3 is specifically expressed in tumor-infiltrating(TIL)regulatory T(Treg)cells[1].The upregulation of ...In this context of Cellular and Molecular Immunology,Sharma and coworkers reported that the glucose transporter Glut3 is specifically expressed in tumor-infiltrating(TIL)regulatory T(Treg)cells[1].The upregulation of Glut3 expression in TIL-Treg cells increased their glucose uptake,which was then used to modify the activity of signaling proteins.The authors specifically investigated the NF-κB subunit c-Rel and showed that its posttranslational modification with O-GlcNAc contributes to the immunosuppressive environment of tumors,opening up possibilities for novel therapeutic approaches.展开更多
Targeting the huge unused bandwidth（BW）of modem telecommunication networks,Bi/Er co-doped silica optical fibers（BEDFs）have been proposed and developed for ultra-broadband,high-gain optical amplifiers covering the ...Targeting the huge unused bandwidth（BW）of modem telecommunication networks,Bi/Er co-doped silica optical fibers（BEDFs）have been proposed and developed for ultra-broadband,high-gain optical amplifiers covering the 1150-1700 nm wavelength range.Ultrabroadband luminescence has been demonstrated in both BEDFs and bismuth/erbium/ytterbium co-doped optical fibers（BEYDFs）fabricated with the modified chemical vapor deposition（MCVD）and in situ doping techniques.Several novel and sophisticated techniques have been developed for the fabrication and characterization of the new active fibers.For controlling the performance of the active fibers,post-treatment processes using high temperature,γ-radiation,and laser light have been introduced.Although many fundamental scientific and technological issues and challenges still remain,several photonic applications,such as fiber sensing,fiber gratings,fiber amplification,fiber lasers,etc.,have already been demonstrated.展开更多
Background:Chronic antibiotic-refractory pouchitis(CARP)is a complication of ileal pouch-anal anastomosis(IPAA),which poses a therapeutic challenge.Vedolizumab,a gut-selective monoclonal antibody to the a4b7 of integr...Background:Chronic antibiotic-refractory pouchitis(CARP)is a complication of ileal pouch-anal anastomosis(IPAA),which poses a therapeutic challenge.Vedolizumab,a gut-selective monoclonal antibody to the a4b7 of integrin,has been used in such patients,but data on its efficacy are limited.Our aim was to assess the efficacy and safety of vedolizumab as induction therapy in CARP patients.Methods:In this single-center,historic cohort,patients with CARP who received vedolizumab between January 2015 to June 2017 were identified and analysed.Patients were included if they had active pouchitis with a total of modified pouch disease activity index(mPDAI)score5 or if unavailable clinician diagnosis of active pouchitis.Pre-treatment and at 3-month posttherapy pouchoscopy and clinical visits were used to calculate mPDAI.Results:A total of 19 patients were included in the study.The mean age was 26.7612.8 years,with 10(53%)males.Nine(47%)patients had been treated with anti-tumor necrosis factor(TNF)agents before colectomy and 10(53%)had anti-TNFs after colectomy and IPAA.Six(32%)patients had improvement in the mPDAI symptom subscores(P=0.031)and 14(74%)had improvement in both endoscopic and total mPDAI scores with a median change of-2 units(both P=0.031).Adverse events were noted only in two(11%)patients and four(21%)required surgery for CARP.Conclusions:Our study suggests that vedolizumab has efficacy and can be safely used for CARP patients.Larger studies with a higher number of patients are required to confirm these findings.展开更多
The doping dependence of dry thermal oxidation rates in n-type 6H-SiC was studied. The oxidation temperature ranged from 1050 to 1150℃ and the nitrogen doping concentration ranged from 9.53× 10^16, 1.44× 10...The doping dependence of dry thermal oxidation rates in n-type 6H-SiC was studied. The oxidation temperature ranged from 1050 to 1150℃ and the nitrogen doping concentration ranged from 9.53× 10^16, 1.44× 10^17, to 2.68×10^18 cm ^3. By combining the modified deal-grove model and Arrhenius equation, the linear and parabolic rate constants, and their corresponding activation energies were extracted. The results show that： higher temperature corresponded to thicker oxides; dry thermal oxidation rate in n-type 6H-SiC depended on the doping concentration; both linear-rate-constant and parabolic-rate-constant increased with the doping concentration; the parabolic activation energy increased from 0.082 to 0.104 e V, both linear and parabolic activation energies increasing with the doping concentration; and, the parabolic pre-exponential factor increased from 2.6 ×10^4 to 2.7 ×10^5nm^2/s, both linear and parabolic pre-exponential factor increasing with doping concentration. Moreover, the experiment also illustrated that it is unreasonable to use a variation of the Arrhenius activation energy to explain the doping dependence of thermal oxidation on SiC.展开更多
文摘Summary: Occlusal-maxillo-facial structural change of crossbite malocclusion after orthodontic therapy by modified ACTIVATOR appliance was investigated. Eighty crossbite cases of deciduous dentition and mixed dentition were treated by modified ACTIVATOR. Through pre- and post-treatment analysis of stone model, Schuller's position X-ray and craniofaciometrics, the change in craniofacial length, width and height in early-phase crossbite malocclusion was studied. The results showed that there was no significant change in the width of maxillary and mandibular dental arch. Maxillary length and protrusion was increased significantly, upper incisors slopped labially. The lower incisors slopped lingually, mental angle decreased more severely. The lower and posterior facial height was increased to normal level.
基金the financial supports from Major Science and Technology project of China Power Engineering Consulting Group Co., Ltd. "Research on Green and digital Intelligent Technology of Sewage Treatment Plant" (No. CEEC2023-ZDYF-09)Technology Innovation Ability Improvement Project of Shandong Province, China (No. 2022TSGC1247)。
文摘Advanced oxidation processes are promising for degradation of the highly chemical stability and refractory methylisothiazolinone(MIT) bactericides in relevant industrial wastewater.In order to assemble a low cost and high performance electrochemical oxidation system for wastewater treatment,granular active carbon(GAC) was decorated by doping Ce,Sn,Sb to synthesize Sn-Sb-Ce/GAC using sol-gel method as particle electrode filled into a three-dimensional(3D) electrochemical reactor.Scanning electron microscopy(SEM),energy-dispersive spectroscopy(EDS) and X-ray diffraction(XRD) experiments revealed that the Sn-Sb-Ce/GAC particle electrode crystal particles were compact and uniform,and the surface structure was improved.The ten cyclic experiments indicated that the Sn-Sb-Ce/GAC particle electrode had high stability and low dissolution of the loaded active substance.The degradation mechanism of MIT was studied under the optimal working conditions of 3D electrode system with GAC of 5 g/L,current density of 20 mA/cm^(2),initial pH 5,electrolyte concentration of Na_(2)SO_(4)0.02 mol/L and reaction time of 120 min.The indirect electrochemical degradation of MIT was dominated by active substance pathway that active chlorine rather than free radicals(·OH) played the main role.Comparing with conventional two-dimensional(2D) electrode system,the 3D electrochemical system has larger active electrode area,higher treatment efficiency and lower energy consumption than the former.The 3D electrochemical system could remove 96.5% of MIT from the actual high-salt reverse osmosis concentrate wastewater in 30 min.It has a certain removal effect on UV_(254)in wastewater,but has a better removal effect on fluorescent substances.This study proposed a new strategy to develop transition metal and rare earth metal particle electrodes using carbon-based materials for high efficient electrocatalytic oxidation in the electrochemical treatment system.
文摘Activated carbon （AC） was modified by tri-butyl phosphate （TBP） for selectively extracting scandium from red mud and characterized by BET （Brunauer-Emmett-Teller） surface area. The modified AC had a preferential adsorption to scandium. The influences of adsorbent dos- age, adsorption temperature, and time on adsorption capacity and selectivity to scandium were examined. An optimum adsorbent dosage （-6.25 g/L）, adsorption temperature （308 K）, and adsorption time （40 min） were figured out. A pseudo-second-order kinetics model was employed for describing the adsorption process of scandium.
基金This work was supported by the National Natural Science Foundation of China(Nos.41530643 and 41807358)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14020203)the Joint Fund of NSFC and Henan(No.U1804110).
文摘The ubiquitous arsenic in groundwater poses a great risk to human health due to its environmental toxicity and carcinogenicity.In the present work,a new adsorbent,δ-MnO2 modified activated carbon,was prepared,and its performance for the uptake of arsenate and arsenite species from aqueous solutions was investigated by batch experiments.Various techniques,including FESEM-EDX,p-XRD,XPS and BET surface area analysis,were employed to characterize the properties of the adsorbent and the arsenic adsorption mechanisms.The results showed thatδ-MnO2 covered on the surface and padded in the pores of the activated carbon.Adsorption kinetic studies revealed that approximately 90.1%and 76.8%of As(Ⅲ)and As(V),respectively,were removed by the adsorbent in the first 9 hr,and adsorption achieved equilibrium within 48 hr.The maximum adsorption capacities of As(V)and As(Ⅲ)at pH 4.0 calculated from Langmuir adsorption isotherms were 13.30 and 12.56 mg/g,respectively.The effect of pH on As(Ⅴ)and As(Ⅲ)removal was similar,and the removal efficiency significantly reduced with the increase of solution pH.Arsenite oxidation and adsorption kinetics showed that the As(Ⅴ)concentration in solution due to As(Ⅲ)oxidation and reductive dissolution of MnO2 increased rapidly during the first 12 min,and then gradually decreased.Based on the XPS analysis,nearly 93.3%of As(Ⅲ)had been oxidized to As(V)on the adsorbent surface and around 38.9%of Mn(Ⅳ)had been reduced to Mn(Ⅱ)after As(Ⅲ)adsorption.This approach provides a possible method for the purification of arsenic-contaminated groundwater.
文摘By using potassium permanganate impregnation method,common activated carbon was processed in 0. 079 mol/L KMnO4 solution at 650℃ to obtain modified activated carbon loaded with manganese oxide,and then different quantities of common activated carbon and modified activated carbon were used to adsorb 0. 3 mg/m^3 formaldehyde. The results showed that carbon and manganese atoms on the surface of modified activated carbon could adsorb formaldehyde,and the removal rate of 0. 3 mg/m^3 formaldehyde by 30 g of modified activated carbon reached 80%,increased one time compared with that by common activated carbon. Different amounts of activated carbon had various effects on the adsorption of formaldehyde,and the best usage of common activated carbon and modified activated carbon was 100 and 30 g respectively.
文摘This article discussed the benzoic acid activated carbons which have changed the types and content of acid oxygen-function groups on the surface of activated carbons and their effect on the adsorption for Hg^0 in simulated flue gas at 140 ℃. These surface acid oxygen function groups were identified by Boehm titration, Fourier transformation infrared spectrum, temperature programmed desorption and X-ray photoelectron spectroscopy. It indicates that the carboxyl, lactone and phenolic were formed when the benzoic acid is loaded on the surface of activated carbons. Among the surface acid oxygen function groups, the carboxyl groups enhance the adsorption capacities of Hg^0 for activated carbons to a greater extent.
文摘The adsorption capacity of activated carbon modified with KMnO4(potassium permanganate)for Cr(VI)from aqueous solution was investigated.The modified activated carbon was characterized by SEM(scanning electron microscopy),FT-IR(Fourier transform infrared spectrometer),and N2 adsorption/desorption tests.Adsorption of Cr(VI)from aqueous solution onto the activated carbon was investigated in a batch system.In the present study,the effect of various parameters such as pH,contact time and initial concentration on the adsorption capacity were determined by ICP-AES(inductively coupled plasma atomic emission spectrometry).The Cr(VI)adsorption on the activated carbon conforms to the Langmuir and Freundlich isothermal adsorption equation.The rates of adsorption were found to conform to pseudo-second order kinetic.The modified activated carbon can be an effective adsorbent for Cr(VI)from the aqueous solution.
基金funded by the National Natural Science Foundation Project (Grant Nos. 41701481 and 41401511)
文摘Glacial lakes in the High Mountain Asia(HMA)are sensitive to global warming and can result in much more severe flood disasters than some largesized lakes.An accurate and robust method for the extraction of glacial lakes is critical to effective management of these natural water resources.Conventional methods often have limitations in terms of low spectral contrast and heterogeneous backgrounds in an image.This study presents a robust and automated method for the yearly mapping of glacial lake over a large scale,which took advantage of the complementarity between the modified normalized difference water index(MNDWI)and the nonlocal active contour model,required only local homogeneity in reflectance features of lake.The cloud computing approach with the Google Earth Engine(GEE)platform was used to process the intensive amount of Landsat 8 images from 2015 (344 path/rows and approximately 7504 scenes).The experimental results were validated by very high resolution images from Chinese GaoFen-1 (GF-1) panchromatic multi-spectral(PMS)and appeared a general good agreement.This is the first time that information regarding the spatial distribution of glacial lakes over the HMA has been derived automatically within quite a short period of time.By integrating it with the relevant indices,it can also be applied to detect other land cover types such as snow or vegetation with improved accuracy.
基金supported by grants from the Deutsche Forschungsgemeinschaft(SCHM1586/6-2 and SCHM1586/11-1)the InnovationsFORUM of the Medical Faculty of the Ruhr University Bochum.
文摘In this context of Cellular and Molecular Immunology,Sharma and coworkers reported that the glucose transporter Glut3 is specifically expressed in tumor-infiltrating(TIL)regulatory T(Treg)cells[1].The upregulation of Glut3 expression in TIL-Treg cells increased their glucose uptake,which was then used to modify the activity of signaling proteins.The authors specifically investigated the NF-κB subunit c-Rel and showed that its posttranslational modification with O-GlcNAc contributes to the immunosuppressive environment of tumors,opening up possibilities for novel therapeutic approaches.
基金Authors are thankful for the support of National Natural Science Foundation of China （Grant Nos. 61520106014, 61405014 and 61377096）, Key Laboratory of In-fiber Integrated Optics, Ministry Education of China, State Key Laboratory of Information Photonics and Optical Communications （Beijing University of Posts and Telecommunica- tions） （No. IPOC2016ZT07）, Key Laboratory of Optical Fiber Sensing ＆ Communications （Education Ministry of China）, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province （No. GD201702） and Science and Technology Commission of Shanghai Municipality, China （Nos. SKLSFO2015-01 and 15220721500）. We also wishes to express our thanks to all members of Photonics ＆ Optical Communications at UNSW, Prof. John Canning and Dr. Kevin Cook at University of Sydney, Prof. Graham Town at Macquarie University, and Prof. Tingyun Wang at Shanghai University for their assistance and contributions.
文摘Targeting the huge unused bandwidth（BW）of modem telecommunication networks,Bi/Er co-doped silica optical fibers（BEDFs）have been proposed and developed for ultra-broadband,high-gain optical amplifiers covering the 1150-1700 nm wavelength range.Ultrabroadband luminescence has been demonstrated in both BEDFs and bismuth/erbium/ytterbium co-doped optical fibers（BEYDFs）fabricated with the modified chemical vapor deposition（MCVD）and in situ doping techniques.Several novel and sophisticated techniques have been developed for the fabrication and characterization of the new active fibers.For controlling the performance of the active fibers,post-treatment processes using high temperature,γ-radiation,and laser light have been introduced.Although many fundamental scientific and technological issues and challenges still remain,several photonic applications,such as fiber sensing,fiber gratings,fiber amplification,fiber lasers,etc.,have already been demonstrated.
文摘Background:Chronic antibiotic-refractory pouchitis(CARP)is a complication of ileal pouch-anal anastomosis(IPAA),which poses a therapeutic challenge.Vedolizumab,a gut-selective monoclonal antibody to the a4b7 of integrin,has been used in such patients,but data on its efficacy are limited.Our aim was to assess the efficacy and safety of vedolizumab as induction therapy in CARP patients.Methods:In this single-center,historic cohort,patients with CARP who received vedolizumab between January 2015 to June 2017 were identified and analysed.Patients were included if they had active pouchitis with a total of modified pouch disease activity index(mPDAI)score5 or if unavailable clinician diagnosis of active pouchitis.Pre-treatment and at 3-month posttherapy pouchoscopy and clinical visits were used to calculate mPDAI.Results:A total of 19 patients were included in the study.The mean age was 26.7612.8 years,with 10(53%)males.Nine(47%)patients had been treated with anti-tumor necrosis factor(TNF)agents before colectomy and 10(53%)had anti-TNFs after colectomy and IPAA.Six(32%)patients had improvement in the mPDAI symptom subscores(P=0.031)and 14(74%)had improvement in both endoscopic and total mPDAI scores with a median change of-2 units(both P=0.031).Adverse events were noted only in two(11%)patients and four(21%)required surgery for CARP.Conclusions:Our study suggests that vedolizumab has efficacy and can be safely used for CARP patients.Larger studies with a higher number of patients are required to confirm these findings.
基金Project supported by the National Natural Science Foundation of China(No.F040405)
文摘The doping dependence of dry thermal oxidation rates in n-type 6H-SiC was studied. The oxidation temperature ranged from 1050 to 1150℃ and the nitrogen doping concentration ranged from 9.53× 10^16, 1.44× 10^17, to 2.68×10^18 cm ^3. By combining the modified deal-grove model and Arrhenius equation, the linear and parabolic rate constants, and their corresponding activation energies were extracted. The results show that： higher temperature corresponded to thicker oxides; dry thermal oxidation rate in n-type 6H-SiC depended on the doping concentration; both linear-rate-constant and parabolic-rate-constant increased with the doping concentration; the parabolic activation energy increased from 0.082 to 0.104 e V, both linear and parabolic activation energies increasing with the doping concentration; and, the parabolic pre-exponential factor increased from 2.6 ×10^4 to 2.7 ×10^5nm^2/s, both linear and parabolic pre-exponential factor increasing with doping concentration. Moreover, the experiment also illustrated that it is unreasonable to use a variation of the Arrhenius activation energy to explain the doping dependence of thermal oxidation on SiC.
