To overcome the shortcomings of the single-shot autocorrelation SSA where only one pulse width is obtained when the SSA is applied to measure the pulse width of ultrashort laser pulses a modified SSA for measuring the...To overcome the shortcomings of the single-shot autocorrelation SSA where only one pulse width is obtained when the SSA is applied to measure the pulse width of ultrashort laser pulses a modified SSA for measuring the spatiotemporal characteristics of ultrashort laser pulses at different spatial positions is proposed. The spatiotemporal characteristics of femtosecond laser pulses output from the Ti sapphire regenerative amplifier system are experimentally measured by the proposed method. It was found that the complex spatial characteristics are measured accurately.The pulse widths at different spatial positions are various which obey the Gaussian distribution.The pulse width at the same spatial position becomes narrow with the increase in input average power when femtosecond laser pulses pass through a carbon disulfide CS2 nonlinear medium.The experimental results verify that the proposed method is valid for measuring the spatiotemporal characteristics of ultrashort laser pulses at different spatial positions.展开更多
According to the connotation and structure of science and technology resources and some relevant data of more than 286 cities at prefecture level and above during 2001-2010, using modified method--Data Envelopment Ana...According to the connotation and structure of science and technology resources and some relevant data of more than 286 cities at prefecture level and above during 2001-2010, using modified method--Data Envelopment Analysis （DEA）, science and tech- nology （S＆T） resource allocation efficiency of different cities in different periods has been figured out, which, uncovers the distributional difference and change law of S＆T resource allocation efficiency from the time-space dimension. Based on that, this paper has analyzed and discussed the spatial distribution pattern and evolution trend of S＆T resource allocation efficiency in different cities by virtue of the Exploratory Spatial Data Analysis （ESDA）. It turned out that： （1） the average of S＆T resource allocation efficiency in cities at prefecture level and above has always stayed at low levels, moreover, with repeated fluctuations between high and low, which shows a decreasing trend year by year. Besides, the gap between the East and the West is widening. （2） The asymmetrical distribution of S＆T resource allocation effi- ciency presents a spatial pattern of successively decreasing from Eastern China, Central China to Western China. The cities whose S＆T resource allocation efficiency are at higher level and high level take on a cluster distribution, which fits well with the 23 forming urban agglomerations in China. （3） The coupling degree between S＆T resource allocation efficiency and economic environment assumes a certain positive correlation, but not completely the same. The differentiation of S＆T resource allocation efficiency is common in regional devel- opment, whose existence and evolution are directly or indirectly influenced by and regarded as the reflection of many elements, such as geographical location, the natural endowment and environment of S＆T resources and so on. （4） In the perspective of the evolution of spatial structure, S＆T resource allocation efficiency of the cities at prefecture level and above shows a notable spatial autocorrelation, which in every period presents a positive correlation. The spatial distribution of S＆T resource allocation efficiency in neighboring cities seems to be similar in group, which tends to escalate stepwise. Meanwhile, the whole differentiation of geographical space has a diminishing tendency. （5） Viewed from LISA agglomeration map of S＆T resource allocation efficiency in different periods, four agglomeration types have changed differently in spatial location and the range of spatial agglomeration. And the conti- nuity of S＆T resource allocation efficiency in geographical space is gradually increasing.展开更多
The article expounds modified asphalt technology by introducing commonly used modifiers and fillers and analyzing the construction technology of modified asphalt.The use of modified asphalt in municipal roads provides...The article expounds modified asphalt technology by introducing commonly used modifiers and fillers and analyzing the construction technology of modified asphalt.The use of modified asphalt in municipal roads provides new alternatives for asphalt pavement materials,but also solves the existing construction problems and reduces project costs.Therefore,the research and application of modified asphalt using new materials and new processes is a crucial aspect in road construction.展开更多
Pericardial barrier destruction,inflammatory cell infiltration,and fibrous tissue hyperplasia,trigger adhesions after cardiac surgery.There are few anti-adhesion materials that are both functional and sutureable for p...Pericardial barrier destruction,inflammatory cell infiltration,and fibrous tissue hyperplasia,trigger adhesions after cardiac surgery.There are few anti-adhesion materials that are both functional and sutureable for pericardial reconstruction.Besides,a few studies have reported on the mechanism of preventing pericardial adhesion.Herein,a functional barrier membrane with sutureability was developed via a modified electrospinning method.It was composed of poly(L-lactide-co-caprolactone)(PLCL)nanofibers,poly(vinyl alcohol)(PVA)aerogel,and melatonin,named PPMT.The PPMT had a special microstructure manifested as a staggered arrangement of nanofibers on the surface and a layered macroporous aerogel structure in a cross-section.Besides providing the porosity and hydrophilicity obtained from PVA,the structure also had suitable mechanical properties for stitching due to the addition of PLCL nanofibers.Furthermore,it inhibited the proliferation of fibroblasts by suppressing the activation of Fas and P53,and achieved anti-inflammatory effects by affecting the activity of inflammatory cells and reducing the release of pro-inflammatory factors,such as interleukin 8(IL-8)and tumor necrosis factorα(TNF-α).Finally,in vivo transplantation showed that it up-regulated the expression of matrix metalloproteinase-1(MMP1)and tissue inhibitor of metalloproteinase-1(TIMP1),and down-regulated the expression of Vinculin and transforming growth factorβ(TGF-β)in the myocardium,thereby reducing the formation of adhesions.Collectively,these results demonstrate a great potential of PPMT membrane for practical application to anti-adhesion.展开更多
The waste fiuorgypsum was modified and applied as a cement retarder. The main chemical composition and mineral structure of the waste fluorgypsum were analyzed. Scanning electron microscopy （SEM） and eight-channel m...The waste fiuorgypsum was modified and applied as a cement retarder. The main chemical composition and mineral structure of the waste fluorgypsum were analyzed. Scanning electron microscopy （SEM） and eight-channel micro-calorimeter （TAM Air） were employed to analyze the changes in morphology and study the application performance of the modified fluorgypsum, respectively. Experimental results indicate that the flexural strength and compressive strength of the modified fiuorgypsurn are roughly equal to those of the natural gypsum. The morphology of the crystal of the fiuorgypsum changes from block particle into trimetric short column. The fluorgypsum crystals stagger mutually and improve the strength of the hardened body. The modified fluorgypsum as cement retarder could delay the hydration, reduce the heat of the hydration and make the setting time, volume stability, and the S03 content of the cement meet the national standards. The modified fluorgypsum is a good substitute for the natural gypsum.展开更多
Technological aspects of modifying the operational characteristics of cold cured silicate rubbers have been developed. The effect of chromium oxide on the resistance of cold-curing silicone compounds to thermal aging,...Technological aspects of modifying the operational characteristics of cold cured silicate rubbers have been developed. The effect of chromium oxide on the resistance of cold-curing silicone compounds to thermal aging, as well as on the physic mechanical properties and dielectric characteristics has been studied. The various content of ultrafine chromium oxide in cold-cured silicone compositions has been investigated, it’s optimal content in an amount of 2 - 5 mass at 100 mass, including low molecular weight rubber. Chromium oxide has been proven to improve the thermal stability of cold-cured silicone compositions. The manufacturing technology and component composition of the composition with high performance.展开更多
目的:基于网络药理学和分子对接技术探究不忘散加味方治疗2型糖尿病(type 2 diabetes mellitus,T2DM)轻度认知障碍的作用机制。方法:利用中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database a...目的:基于网络药理学和分子对接技术探究不忘散加味方治疗2型糖尿病(type 2 diabetes mellitus,T2DM)轻度认知障碍的作用机制。方法:利用中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)和BATMAN-TCM数据库筛选不忘散加味方的药物成分及潜在作用靶点;通过在线人类孟德尔遗传数据库(online mendelian inheritance in man,OMIM)及人类基因数据库(the human gene database,GeneCards)筛选疾病相关靶点,获取疾病与药物交集靶点,得出不忘散加味方治疗T2DM轻度认知障碍的潜在作用靶点;通过Cytoscape 3.8.2软件构建“药物-成分-作用靶点”网络;将疾病与药物交集靶点导入STRING数据库,构建蛋白-蛋白互作(proteinprotein interactions,PPI)网络,筛选核心靶点;借助核心靶基因导入基因功能注释数据库(the database for annotation visualization and integrated discovery,DAVID)对疾病与药物交集靶点做基因本体论(gene ontology,GO)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析;通过AutoDock Vina软件对筛选出的关键成分与靶点进行分子对接,验证药物与疾病的作用关系。结果:共筛选得到不忘散加味方活性成分135个,不忘散加味方与T2DM轻度认知障碍交集靶点293个;获得槲皮素、β-谷甾醇、山柰酚、木犀草素、豆甾醇等关键活性化合物;筛选得到TP53、IL-6、AKT1、TNF、STAT3、IL-1β、EGFR、JUN、INS、BCL2等核心靶点;潜在作用靶点主要富集在脂质与动脉粥样硬化通路、糖尿病并发症AGE-RAGE、流体剪切应力与动脉粥样硬化通路等。结论:不忘散加味存在多种活性成分,可能通过多个潜在靶点、多条信号通路发挥对T2DM合并轻度认知障碍的治疗作用。展开更多
基金The National Natural Science Foundation of China(No.61171081,No.61471164)the Natural Science Foundation of Hunan Province(No.14JJ6043)
文摘To overcome the shortcomings of the single-shot autocorrelation SSA where only one pulse width is obtained when the SSA is applied to measure the pulse width of ultrashort laser pulses a modified SSA for measuring the spatiotemporal characteristics of ultrashort laser pulses at different spatial positions is proposed. The spatiotemporal characteristics of femtosecond laser pulses output from the Ti sapphire regenerative amplifier system are experimentally measured by the proposed method. It was found that the complex spatial characteristics are measured accurately.The pulse widths at different spatial positions are various which obey the Gaussian distribution.The pulse width at the same spatial position becomes narrow with the increase in input average power when femtosecond laser pulses pass through a carbon disulfide CS2 nonlinear medium.The experimental results verify that the proposed method is valid for measuring the spatiotemporal characteristics of ultrashort laser pulses at different spatial positions.
基金Key Projects of Philosophy of the Social Science funded by the Ministry of Education,No.11JD039National Key Public Bidding Project for Soft Science Research Plan,No.2012GXS1D002National Natural Science Foundation of China,No.41001083
文摘According to the connotation and structure of science and technology resources and some relevant data of more than 286 cities at prefecture level and above during 2001-2010, using modified method--Data Envelopment Analysis （DEA）, science and tech- nology （S＆T） resource allocation efficiency of different cities in different periods has been figured out, which, uncovers the distributional difference and change law of S＆T resource allocation efficiency from the time-space dimension. Based on that, this paper has analyzed and discussed the spatial distribution pattern and evolution trend of S＆T resource allocation efficiency in different cities by virtue of the Exploratory Spatial Data Analysis （ESDA）. It turned out that： （1） the average of S＆T resource allocation efficiency in cities at prefecture level and above has always stayed at low levels, moreover, with repeated fluctuations between high and low, which shows a decreasing trend year by year. Besides, the gap between the East and the West is widening. （2） The asymmetrical distribution of S＆T resource allocation effi- ciency presents a spatial pattern of successively decreasing from Eastern China, Central China to Western China. The cities whose S＆T resource allocation efficiency are at higher level and high level take on a cluster distribution, which fits well with the 23 forming urban agglomerations in China. （3） The coupling degree between S＆T resource allocation efficiency and economic environment assumes a certain positive correlation, but not completely the same. The differentiation of S＆T resource allocation efficiency is common in regional devel- opment, whose existence and evolution are directly or indirectly influenced by and regarded as the reflection of many elements, such as geographical location, the natural endowment and environment of S＆T resources and so on. （4） In the perspective of the evolution of spatial structure, S＆T resource allocation efficiency of the cities at prefecture level and above shows a notable spatial autocorrelation, which in every period presents a positive correlation. The spatial distribution of S＆T resource allocation efficiency in neighboring cities seems to be similar in group, which tends to escalate stepwise. Meanwhile, the whole differentiation of geographical space has a diminishing tendency. （5） Viewed from LISA agglomeration map of S＆T resource allocation efficiency in different periods, four agglomeration types have changed differently in spatial location and the range of spatial agglomeration. And the conti- nuity of S＆T resource allocation efficiency in geographical space is gradually increasing.
文摘The article expounds modified asphalt technology by introducing commonly used modifiers and fillers and analyzing the construction technology of modified asphalt.The use of modified asphalt in municipal roads provides new alternatives for asphalt pavement materials,but also solves the existing construction problems and reduces project costs.Therefore,the research and application of modified asphalt using new materials and new processes is a crucial aspect in road construction.
基金The National Natural Science Fund of China(81873923)Shanghai Science and Technology Development Fund(20Y11910600,18441901900)supported this study.
文摘Pericardial barrier destruction,inflammatory cell infiltration,and fibrous tissue hyperplasia,trigger adhesions after cardiac surgery.There are few anti-adhesion materials that are both functional and sutureable for pericardial reconstruction.Besides,a few studies have reported on the mechanism of preventing pericardial adhesion.Herein,a functional barrier membrane with sutureability was developed via a modified electrospinning method.It was composed of poly(L-lactide-co-caprolactone)(PLCL)nanofibers,poly(vinyl alcohol)(PVA)aerogel,and melatonin,named PPMT.The PPMT had a special microstructure manifested as a staggered arrangement of nanofibers on the surface and a layered macroporous aerogel structure in a cross-section.Besides providing the porosity and hydrophilicity obtained from PVA,the structure also had suitable mechanical properties for stitching due to the addition of PLCL nanofibers.Furthermore,it inhibited the proliferation of fibroblasts by suppressing the activation of Fas and P53,and achieved anti-inflammatory effects by affecting the activity of inflammatory cells and reducing the release of pro-inflammatory factors,such as interleukin 8(IL-8)and tumor necrosis factorα(TNF-α).Finally,in vivo transplantation showed that it up-regulated the expression of matrix metalloproteinase-1(MMP1)and tissue inhibitor of metalloproteinase-1(TIMP1),and down-regulated the expression of Vinculin and transforming growth factorβ(TGF-β)in the myocardium,thereby reducing the formation of adhesions.Collectively,these results demonstrate a great potential of PPMT membrane for practical application to anti-adhesion.
基金Project(21003014) supported by the National Natural Science Foundation of ChinaProject(2010FJ3167) supported by the Hunan Provincial Science and Technology Program,ChinaProject(K1104029-11) supported by the Changsha IT Project
文摘The waste fiuorgypsum was modified and applied as a cement retarder. The main chemical composition and mineral structure of the waste fluorgypsum were analyzed. Scanning electron microscopy （SEM） and eight-channel micro-calorimeter （TAM Air） were employed to analyze the changes in morphology and study the application performance of the modified fluorgypsum, respectively. Experimental results indicate that the flexural strength and compressive strength of the modified fiuorgypsurn are roughly equal to those of the natural gypsum. The morphology of the crystal of the fiuorgypsum changes from block particle into trimetric short column. The fluorgypsum crystals stagger mutually and improve the strength of the hardened body. The modified fluorgypsum as cement retarder could delay the hydration, reduce the heat of the hydration and make the setting time, volume stability, and the S03 content of the cement meet the national standards. The modified fluorgypsum is a good substitute for the natural gypsum.
文摘Technological aspects of modifying the operational characteristics of cold cured silicate rubbers have been developed. The effect of chromium oxide on the resistance of cold-curing silicone compounds to thermal aging, as well as on the physic mechanical properties and dielectric characteristics has been studied. The various content of ultrafine chromium oxide in cold-cured silicone compositions has been investigated, it’s optimal content in an amount of 2 - 5 mass at 100 mass, including low molecular weight rubber. Chromium oxide has been proven to improve the thermal stability of cold-cured silicone compositions. The manufacturing technology and component composition of the composition with high performance.
文摘目的:基于网络药理学和分子对接技术探究不忘散加味方治疗2型糖尿病(type 2 diabetes mellitus,T2DM)轻度认知障碍的作用机制。方法:利用中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)和BATMAN-TCM数据库筛选不忘散加味方的药物成分及潜在作用靶点;通过在线人类孟德尔遗传数据库(online mendelian inheritance in man,OMIM)及人类基因数据库(the human gene database,GeneCards)筛选疾病相关靶点,获取疾病与药物交集靶点,得出不忘散加味方治疗T2DM轻度认知障碍的潜在作用靶点;通过Cytoscape 3.8.2软件构建“药物-成分-作用靶点”网络;将疾病与药物交集靶点导入STRING数据库,构建蛋白-蛋白互作(proteinprotein interactions,PPI)网络,筛选核心靶点;借助核心靶基因导入基因功能注释数据库(the database for annotation visualization and integrated discovery,DAVID)对疾病与药物交集靶点做基因本体论(gene ontology,GO)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析;通过AutoDock Vina软件对筛选出的关键成分与靶点进行分子对接,验证药物与疾病的作用关系。结果:共筛选得到不忘散加味方活性成分135个,不忘散加味方与T2DM轻度认知障碍交集靶点293个;获得槲皮素、β-谷甾醇、山柰酚、木犀草素、豆甾醇等关键活性化合物;筛选得到TP53、IL-6、AKT1、TNF、STAT3、IL-1β、EGFR、JUN、INS、BCL2等核心靶点;潜在作用靶点主要富集在脂质与动脉粥样硬化通路、糖尿病并发症AGE-RAGE、流体剪切应力与动脉粥样硬化通路等。结论:不忘散加味存在多种活性成分,可能通过多个潜在靶点、多条信号通路发挥对T2DM合并轻度认知障碍的治疗作用。
