Under the framework of classical genetics and Darwinian theory,DNA sequence variation has long been considered the sole driving force behind the formation of organismal traits.Species passively undergo natural selecti...Under the framework of classical genetics and Darwinian theory,DNA sequence variation has long been considered the sole driving force behind the formation of organismal traits.Species passively undergo natural selection through random DNA mutations,gradually adapting to their environments and sustaining their populations(Laland et al.,2014).However,epigenetic studies have revealed that certain traits or phenotypes caused by epigenetic modifications,such as DNA(de)methylation(without any DNA sequence change),can be inherited across generations—a phenomenon termed transgenerational epigenetic inheritance(TEI)(Fitz-James and Cavalli,2022).展开更多
基金supported by grants from the Guangdong Major Project of Basic and Applied Basic Research(2021B0301030004)the National Natural Science Foundation of China(32488302)+1 种基金the Agricultural Science and Technology Innovation Program(CAAS-ZDRW202404)the China Postdoctoral Science Foundation(2023M733834).
文摘Under the framework of classical genetics and Darwinian theory,DNA sequence variation has long been considered the sole driving force behind the formation of organismal traits.Species passively undergo natural selection through random DNA mutations,gradually adapting to their environments and sustaining their populations(Laland et al.,2014).However,epigenetic studies have revealed that certain traits or phenotypes caused by epigenetic modifications,such as DNA(de)methylation(without any DNA sequence change),can be inherited across generations—a phenomenon termed transgenerational epigenetic inheritance(TEI)(Fitz-James and Cavalli,2022).
