Dear Editor,Lactate has long been recognized as a canonical end product of glycolysis and a hallmark metabolic byproduct of tumor cells(Vander Heiden et al.,2009).A seminal study identified histone lysine lactylation(...Dear Editor,Lactate has long been recognized as a canonical end product of glycolysis and a hallmark metabolic byproduct of tumor cells(Vander Heiden et al.,2009).A seminal study identified histone lysine lactylation(Kla)as a hitherto unrecognized epigenetic modification,demonstrating its direct role in activating chromatin-driven gene transcription(Zhang et al.,2019).展开更多
基金supported by the National Natural Science Foundation of China(82472705,32422082)。
文摘Dear Editor,Lactate has long been recognized as a canonical end product of glycolysis and a hallmark metabolic byproduct of tumor cells(Vander Heiden et al.,2009).A seminal study identified histone lysine lactylation(Kla)as a hitherto unrecognized epigenetic modification,demonstrating its direct role in activating chromatin-driven gene transcription(Zhang et al.,2019).
