We developed magnetically driven bionic drug-loaded nanorobots(MDNs)to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional(3D)magnetic manipulation platform(MMP)system to prec...We developed magnetically driven bionic drug-loaded nanorobots(MDNs)to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional(3D)magnetic manipulation platform(MMP)system to precisely control their movement mode.MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles(7.02±0.18 nm).Doxorubicin(12%±2%[w/w])was encapsulated in MDNs by an imide bond.MDNs could imitate the movement mode of a school of wild herrings(e.g.,re-dispersion/arrangement/vortex/directional movement)to adapt to the changing and complex physiological environment through the 3D MMP system.MDNs overcame blood flow resistance and biological barriers using optimized magnetic driving properties according to in vivo imaging(magnetic resonance imaging and fluorescence)and histopathology.The performance of fabricated MDNs was verified through cells and tumor-bearing mouse models.The MDNs showed high efficiency of drug delivery and targeting at the tumor site(>10-fold),lower toxicity than free doxorubicin(5 mg/kg body weight),activated immune response in the tumor site,and significantly lengthened survival for mice.The synergistic interaction between MDNs and the 3D MMP system underscores the immense potential of this drug delivery system,indicating a potential revolution in the field of tumor chemotherapy.展开更多
基金supported by the National Key R&D Program of China(2022YFA1207300,2021YFA1201204,and 2022YFF1502000)the directional institutional-ized scientific research platform relying on the Beijing Synchrotron Radiation Facility(BSRF)of the Chinese Academy of Sclences,the Science and Technology Plan Program of Beijing(Z221100007122006)the Beijing Municipal Fund for Distinguished Young Scholars(grant JQ22022).
文摘We developed magnetically driven bionic drug-loaded nanorobots(MDNs)to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional(3D)magnetic manipulation platform(MMP)system to precisely control their movement mode.MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles(7.02±0.18 nm).Doxorubicin(12%±2%[w/w])was encapsulated in MDNs by an imide bond.MDNs could imitate the movement mode of a school of wild herrings(e.g.,re-dispersion/arrangement/vortex/directional movement)to adapt to the changing and complex physiological environment through the 3D MMP system.MDNs overcame blood flow resistance and biological barriers using optimized magnetic driving properties according to in vivo imaging(magnetic resonance imaging and fluorescence)and histopathology.The performance of fabricated MDNs was verified through cells and tumor-bearing mouse models.The MDNs showed high efficiency of drug delivery and targeting at the tumor site(>10-fold),lower toxicity than free doxorubicin(5 mg/kg body weight),activated immune response in the tumor site,and significantly lengthened survival for mice.The synergistic interaction between MDNs and the 3D MMP system underscores the immense potential of this drug delivery system,indicating a potential revolution in the field of tumor chemotherapy.
