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From CRISPR screens to circuits:identifying key regulators in T cell activation and state transitions
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作者 Maria Silvia Roman Azcona Toni Cathomen Claudio Mussolino 《Signal Transduction and Targeted Therapy》 2025年第5期2523-2524,共2页
A recent study published in Nature by Maya M.Arce and colleagues unveils the role of central gene circuits in governing the delicate balance between T cell rest and T cell activation.This work bridges fundamental mole... A recent study published in Nature by Maya M.Arce and colleagues unveils the role of central gene circuits in governing the delicate balance between T cell rest and T cell activation.This work bridges fundamental molecular biology with findings in preclinical models,providing insights into context-specific gene regulation and potential therapeutic targets for immune modulation. 展开更多
关键词 T cell activation preclinical modelsproviding Gene circuits fundamental molecular biology CRISPR screens Immune modulation immune modulation State transitions
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