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SPME-GCMS分析不同芒果品种香气成分差异 被引量:1
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作者 李玖慧 彭云露 +2 位作者 陈清勉 袁靖喆 易小平 《广州化工》 2025年第8期112-114,130,共4页
选取台农、贵妃、凯特三种芒果为研究对象,对其果实中挥发性成分进行分析。比较不同萃取材料、不同萃取温度等因素对萃取结果的影响,并对进样时间、柱温程序进行比较和方法优化,确定一种顶空-微固萃取-气质联用测定芒果香气成分的方法... 选取台农、贵妃、凯特三种芒果为研究对象,对其果实中挥发性成分进行分析。比较不同萃取材料、不同萃取温度等因素对萃取结果的影响,并对进样时间、柱温程序进行比较和方法优化,确定一种顶空-微固萃取-气质联用测定芒果香气成分的方法。结果表明,三种芒果品种的主要香气成分均为萜烯类化合物。台农和贵妃中异松油烯的相对含量最高,分别为79.94%、67.88%,凯特芒果相对含量最高的香气成分为3-蒈烯,相对含量为55.68%。 展开更多
关键词 挥发性气味 SPME-gcms 芒果 不同品种
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基于Py-GCMS定量分析不同覆膜年限土壤中微塑料含量以及微生物群落变化 被引量:1
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作者 黄彭鑫悦 刘宇航 +2 位作者 吕凤媛 张艳艳 高雪松 《农业环境科学学报》 北大核心 2025年第5期1303-1311,共9页
为探究不同覆膜年限农田中微塑料的污染水平及微生物群落的变化,本研究采集覆膜年限为5、15 a以及从未覆膜的农田土壤,采用热裂解气相色谱质谱联用仪(Py-GCMS)定量微塑料含量并采用高通量测序手段,探讨不同覆膜年限对土壤微塑料含量的影... 为探究不同覆膜年限农田中微塑料的污染水平及微生物群落的变化,本研究采集覆膜年限为5、15 a以及从未覆膜的农田土壤,采用热裂解气相色谱质谱联用仪(Py-GCMS)定量微塑料含量并采用高通量测序手段,探讨不同覆膜年限对土壤微塑料含量的影响,以及残膜生态位微生物和土壤微生物群落的变化。结果表明:随着覆膜年限的增加,土壤中微塑料的含量呈上升趋势。5 a覆膜(A地)土壤中微塑料含量为0.47 g·kg^(-1),而15 a覆膜(B地)土壤中微塑料含量为2.66 g·kg^(-1);此外,覆膜时间对土壤微生物群落丰度、多样性和种类组成产生了显著影响。5 a覆膜(A地)土壤中的细菌丰富度和多样性均高于膜上细菌,而15 a覆膜(B地)土壤中的细菌丰富度虽然低于膜上细菌,但多样性却高于膜上细菌。5 a覆膜(A地)土壤中的真菌丰富度高于膜上真菌,但土壤中的真菌多样性低于膜上真菌,而15 a覆膜(B地)土壤中的真菌丰富度和多样性均高于膜上真菌。尽管地理位置、作物种植种类以及农业生产方式不同,但两地残膜表面均富集了具有降解塑料能力的菌株,包括假单胞细菌属、类诺卡氏菌属等,证明塑料残膜的存在促进了土壤中特异细菌的生长。研究表明,随着覆膜年限增加土壤微塑料污染水平加剧,同时微塑料会导致周围环境的微生物群落发生改变。 展开更多
关键词 微塑料 Py-gcms 微塑料含量 微生物群落 地膜
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AntDAS-GCMS结合DLLME-GCMS高通量精准表征不同来源无花果提取物中的挥发性成分
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作者 仝智强 樊亚玲 +2 位作者 何育萍 王瑶 彭军仓 《化学试剂》 2025年第11期87-94,共8页
天然植物提取物在食品饮料、日化产品、烟草等领域应用广泛,产品品质极易受原料产地、品种、工艺等因素影响,波动较大。如何实现高效、精准的化学成分解析是产品品质中亟待解决的一个难题。以无花果提取物为例,提出了基于AntDAS-GCMS结... 天然植物提取物在食品饮料、日化产品、烟草等领域应用广泛,产品品质极易受原料产地、品种、工艺等因素影响,波动较大。如何实现高效、精准的化学成分解析是产品品质中亟待解决的一个难题。以无花果提取物为例,提出了基于AntDAS-GCMS结合Dispersive Liquid-Liquid Microextraction-Mass Spectrometry(DLLME-GCMS)实现天然植物提取物中挥发性成分解析的新策略。基于AntDAS-GCMS解析结果为导向的样本前处理条件优化有助于提升化合物提取效率,从而提高化合物覆盖度。多样本分析中的批处理分析结果表明AntDAS-GCMS能够发现不同来源无花果提取物的整体及细节差异,并实现化合物的高通量精准鉴定。最终,基于所开发的植物提取物挥发性成分高通量精准解析策略,实现了无花果中36种化合物的鉴定,涵盖了酯类(9种)、酮类(7种)、醇类(7种)、醛类(5种)、萜类(4种)、杂环类(2种)、酚类(1种)以及二肽类(1种)。不同类别化合物的峰面积总和分析表明醇类占比最高(31.8%),其次为醛类(30.3%)和酯类(25.0%)。所发展的分析策略有望为植物中挥发性成分的解析及品质监控提供新的研究思路。 展开更多
关键词 植物提取物 无花果提取物 AntDAS-gcms DLLME-gcms 化学计量学
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Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine Learning Models 被引量:1
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作者 Duc-Dam Nguyen Nguyen Viet Tiep +5 位作者 Quynh-Anh Thi Bui Hiep Van Le Indra Prakash Romulus Costache Manish Pandey Binh Thai Pham 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期467-500,共34页
This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble lear... This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making. 展开更多
关键词 Landslide susceptibility map spatial analysis ensemble modelling information values(IV)
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An integrated method of data-driven and mechanism models for formation evaluation with logs 被引量:1
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作者 Meng-Lu Kang Jun Zhou +4 位作者 Juan Zhang Li-Zhi Xiao Guang-Zhi Liao Rong-Bo Shao Gang Luo 《Petroleum Science》 2025年第3期1110-1124,共15页
We propose an integrated method of data-driven and mechanism models for well logging formation evaluation,explicitly focusing on predicting reservoir parameters,such as porosity and water saturation.Accurately interpr... We propose an integrated method of data-driven and mechanism models for well logging formation evaluation,explicitly focusing on predicting reservoir parameters,such as porosity and water saturation.Accurately interpreting these parameters is crucial for effectively exploring and developing oil and gas.However,with the increasing complexity of geological conditions in this industry,there is a growing demand for improved accuracy in reservoir parameter prediction,leading to higher costs associated with manual interpretation.The conventional logging interpretation methods rely on empirical relationships between logging data and reservoir parameters,which suffer from low interpretation efficiency,intense subjectivity,and suitability for ideal conditions.The application of artificial intelligence in the interpretation of logging data provides a new solution to the problems existing in traditional methods.It is expected to improve the accuracy and efficiency of the interpretation.If large and high-quality datasets exist,data-driven models can reveal relationships of arbitrary complexity.Nevertheless,constructing sufficiently large logging datasets with reliable labels remains challenging,making it difficult to apply data-driven models effectively in logging data interpretation.Furthermore,data-driven models often act as“black boxes”without explaining their predictions or ensuring compliance with primary physical constraints.This paper proposes a machine learning method with strong physical constraints by integrating mechanism and data-driven models.Prior knowledge of logging data interpretation is embedded into machine learning regarding network structure,loss function,and optimization algorithm.We employ the Physically Informed Auto-Encoder(PIAE)to predict porosity and water saturation,which can be trained without labeled reservoir parameters using self-supervised learning techniques.This approach effectively achieves automated interpretation and facilitates generalization across diverse datasets. 展开更多
关键词 Well log Reservoir evaluation Label scarcity Mechanism model Data-driven model Physically informed model Self-supervised learning Machine learning
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Predictability Study of Weather and Climate Events Related to Artificial Intelligence Models 被引量:2
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作者 Mu MU Bo QIN Guokun DAI 《Advances in Atmospheric Sciences》 2025年第1期1-8,共8页
Conducting predictability studies is essential for tracing the source of forecast errors,which not only leads to the improvement of observation and forecasting systems,but also enhances the understanding of weather an... Conducting predictability studies is essential for tracing the source of forecast errors,which not only leads to the improvement of observation and forecasting systems,but also enhances the understanding of weather and climate phenomena.In the past few decades,dynamical numerical models have been the primary tools for predictability studies,achieving significant progress.Nowadays,with the advances in artificial intelligence(AI)techniques and accumulations of vast meteorological data,modeling weather and climate events using modern data-driven approaches is becoming trendy,where FourCastNet,Pangu-Weather,and GraphCast are successful pioneers.In this perspective article,we suggest AI models should not be limited to forecasting but be expanded to predictability studies,leveraging AI's advantages of high efficiency and self-contained optimization modules.To this end,we first remark that AI models should possess high simulation capability with fine spatiotemporal resolution for two kinds of predictability studies.AI models with high simulation capabilities comparable to numerical models can be considered to provide solutions to partial differential equations in a data-driven way.Then,we highlight several specific predictability issues with well-determined nonlinear optimization formulizations,which can be well-studied using AI models,holding significant scientific value.In addition,we advocate for the incorporation of AI models into the synergistic cycle of the cognition–observation–model paradigm.Comprehensive predictability studies have the potential to transform“big data”to“big and better data”and shift the focus from“AI for forecasts”to“AI for science”,ultimately advancing the development of the atmospheric and oceanic sciences. 展开更多
关键词 PREDICTABILITY artificial intelligence models simulation and forecasting nonlinear optimization cognition–observation–model paradigm
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Sensorless battery expansion estimation using electromechanical coupled models and machine learning 被引量:1
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作者 Xue Cai Caiping Zhang +4 位作者 Jue Chen Zeping Chen Linjing Zhang Dirk Uwe Sauer Weihan Li 《Journal of Energy Chemistry》 2025年第6期142-157,I0004,共17页
Developing sensorless techniques for estimating battery expansion is essential for effective mechanical state monitoring,improving the accuracy of digital twin simulation and abnormality detection.Therefore,this paper... Developing sensorless techniques for estimating battery expansion is essential for effective mechanical state monitoring,improving the accuracy of digital twin simulation and abnormality detection.Therefore,this paper presents a data-driven approach to expansion estimation using electromechanical coupled models with machine learning.The proposed method integrates reduced-order impedance models with data-driven mechanical models,coupling the electrochemical and mechanical states through the state of charge(SOC)and mechanical pressure within a state estimation framework.The coupling relationship was established through experimental insights into pressure-related impedance parameters and the nonlinear mechanical behavior with SOC and pressure.The data-driven model was interpreted by introducing a novel swelling coefficient defined by component stiffnesses to capture the nonlinear mechanical behavior across various mechanical constraints.Sensitivity analysis of the impedance model shows that updating model parameters with pressure can reduce the mean absolute error of simulated voltage by 20 mV and SOC estimation error by 2%.The results demonstrate the model's estimation capabilities,achieving a root mean square error of less than 1 kPa when the maximum expansion force is from 30 kPa to 120 kPa,outperforming calibrated stiffness models and other machine learning techniques.The model's robustness and generalizability are further supported by its effective handling of SOC estimation and pressure measurement errors.This work highlights the importance of the proposed framework in enhancing state estimation and fault diagnosis for lithium-ion batteries. 展开更多
关键词 Sensorless estimation Electromechanical coupling Impedance model Data-driven model Mechanical pressure
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Large language models for robotics:Opportunities,challenges,and perspectives 被引量:3
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作者 Jiaqi Wang Enze Shi +7 位作者 Huawen Hu Chong Ma Yiheng Liu Xuhui Wang Yincheng Yao Xuan Liu Bao Ge Shu Zhang 《Journal of Automation and Intelligence》 2025年第1期52-64,共13页
Large language models(LLMs)have undergone significant expansion and have been increasingly integrated across various domains.Notably,in the realm of robot task planning,LLMs harness their advanced reasoning and langua... Large language models(LLMs)have undergone significant expansion and have been increasingly integrated across various domains.Notably,in the realm of robot task planning,LLMs harness their advanced reasoning and language comprehension capabilities to formulate precise and efficient action plans based on natural language instructions.However,for embodied tasks,where robots interact with complex environments,textonly LLMs often face challenges due to a lack of compatibility with robotic visual perception.This study provides a comprehensive overview of the emerging integration of LLMs and multimodal LLMs into various robotic tasks.Additionally,we propose a framework that utilizes multimodal GPT-4V to enhance embodied task planning through the combination of natural language instructions and robot visual perceptions.Our results,based on diverse datasets,indicate that GPT-4V effectively enhances robot performance in embodied tasks.This extensive survey and evaluation of LLMs and multimodal LLMs across a variety of robotic tasks enriches the understanding of LLM-centric embodied intelligence and provides forward-looking insights towards bridging the gap in Human-Robot-Environment interaction. 展开更多
关键词 Large language models ROBOTICS Generative AI Embodied intelligence
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Dynamic intelligent prediction approach for landslide displacement based on biological growth models and CNN-LSTM 被引量:2
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作者 WANG Ziqian FANG Xiangwei +3 位作者 ZHANG Wengang WANG Luqi WANG Kai CHEN Chao 《Journal of Mountain Science》 2025年第1期71-88,共18页
Influenced by complex external factors,the displacement-time curve of reservoir landslides demonstrates both short-term and long-term diversity and dynamic complexity.It is difficult for existing methods,including Reg... Influenced by complex external factors,the displacement-time curve of reservoir landslides demonstrates both short-term and long-term diversity and dynamic complexity.It is difficult for existing methods,including Regression models and Neural network models,to perform multi-characteristic coupled displacement prediction because they fail to consider landslide creep characteristics.This paper integrates the creep characteristics of landslides with non-linear intelligent algorithms and proposes a dynamic intelligent landslide displacement prediction method based on a combination of the Biological Growth model(BG),Convolutional Neural Network(CNN),and Long ShortTerm Memory Network(LSTM).This prediction approach improves three different biological growth models,thereby effectively extracting landslide creep characteristic parameters.Simultaneously,it integrates external factors(rainfall and reservoir water level)to construct an internal and external comprehensive dataset for data augmentation,which is input into the improved CNN-LSTM model.Thereafter,harnessing the robust feature extraction capabilities and spatial translation invariance of CNN,the model autonomously captures short-term local fluctuation characteristics of landslide displacement,and combines LSTM's efficient handling of long-term nonlinear temporal data to improve prediction performance.An evaluation of the Liangshuijing landslide in the Three Gorges Reservoir Area indicates that BG-CNN-LSTM exhibits high prediction accuracy,excellent generalization capabilities when dealing with various types of landslides.The research provides an innovative approach to achieving the whole-process,realtime,high-precision displacement predictions for multicharacteristic coupled landslides. 展开更多
关键词 Reservoir landslides Displacement prediction CNN LSTM Biological growth model
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Behavioral Animal Models and Neural-Circuit Framework of Depressive Disorder 被引量:1
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作者 Xiangyun Tian Scott J.Russo Long Li 《Neuroscience Bulletin》 2025年第2期272-288,共17页
Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experienci... Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention. 展开更多
关键词 DEPRESSION Animal models STRESS Neural circuits
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Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction
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作者 BingKun Yu PengHao Tian +6 位作者 XiangHui Xue Christopher JScott HaiLun Ye JianFei Wu Wen Yi TingDi Chen XianKang Dou 《Earth and Planetary Physics》 EI CAS 2025年第1期10-19,共10页
Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,... Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 km.Because they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite systems.In this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde observations.The deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular. 展开更多
关键词 ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence
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The protective effects of melatonin against electromagnetic waves of cell phones in animal models:A systematic review 被引量:1
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作者 Mohammad Amiri Habibolah Khazaie Masoud Mohammadi 《Animal Models and Experimental Medicine》 2025年第4期629-637,共9页
Background:Due to the widespread use of cell phone devices today,numerous re-search studies have focused on the adverse effects of electromagnetic radiation on human neuropsychological and reproductive systems.In most... Background:Due to the widespread use of cell phone devices today,numerous re-search studies have focused on the adverse effects of electromagnetic radiation on human neuropsychological and reproductive systems.In most studies,oxidative stress has been identified as the primary pathophysiological mechanism underlying the harmful effects of electromagnetic waves.This paper aims to provide a holistic review of the protective effects of melatonin against cell phone-induced electromag-netic waves on various organs.Methods:This study is a systematic review of articles chosen by searching Google Scholar,PubMed,Embase,Scopus,Web of Science,and Science Direct using the key-words‘melatonin’,‘cell phone radiation’,and‘animal model’.The search focused on articles written in English,which were reviewed and evaluated.The PRISMA process was used to review the articles chosen for the study,and the JBI checklist was used to check the quality of the reviewed articles.Results:In the final review of 11 valid quality-checked articles,the effects of me-latonin in the intervention group,the effects of electromagnetic waves in the case group,and the amount of melatonin in the chosen organ,i.e.brain,skin,eyes,testis and the kidney were thoroughly examined.The review showed that electromagnetic waves increase cellular anti-oxidative activity in different tissues such as the brain,the skin,the eyes,the testis,and the kidneys.Melatonin can considerably augment the anti-oxidative system of cells and protect tissues;these measurements were sig-nificantly increased in control groups.Electromagnetic waves can induce tissue atro-phy and cell death in various organs including the brain and the skin and this effect was highly decreased by melatonin.Conclusion:Our review confirms that melatonin effectively protects the organs of an-imal models against electromagnetic waves.In light of this conclusion and the current world-wide use of melatonin,future studies should advance to the stages of human clinical trials.We also recommend that more research in the field of melatonin physi-ology is conducted in order to protect exposed cells from dying and that melatonin should be considered as a pharmaceutical option for treating the complications result-ing from electromagnetic waves in humans. 展开更多
关键词 animal model cell phone radiation MELATONIN
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Evaluating research quality with Large Language Models:An analysis of ChatGPT’s effectiveness with different settings and inputs 被引量:1
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作者 Mike Thelwall 《Journal of Data and Information Science》 2025年第1期7-25,共19页
Purpose:Evaluating the quality of academic journal articles is a time consuming but critical task for national research evaluation exercises,appointments and promotion.It is therefore important to investigate whether ... Purpose:Evaluating the quality of academic journal articles is a time consuming but critical task for national research evaluation exercises,appointments and promotion.It is therefore important to investigate whether Large Language Models(LLMs)can play a role in this process.Design/methodology/approach:This article assesses which ChatGPT inputs(full text without tables,figures,and references;title and abstract;title only)produce better quality score estimates,and the extent to which scores are affected by ChatGPT models and system prompts.Findings:The optimal input is the article title and abstract,with average ChatGPT scores based on these(30 iterations on a dataset of 51 papers)correlating at 0.67 with human scores,the highest ever reported.ChatGPT 4o is slightly better than 3.5-turbo(0.66),and 4o-mini(0.66).Research limitations:The data is a convenience sample of the work of a single author,it only includes one field,and the scores are self-evaluations.Practical implications:The results suggest that article full texts might confuse LLM research quality evaluations,even though complex system instructions for the task are more effective than simple ones.Thus,whilst abstracts contain insufficient information for a thorough assessment of rigour,they may contain strong pointers about originality and significance.Finally,linear regression can be used to convert the model scores into the human scale scores,which is 31%more accurate than guessing.Originality/value:This is the first systematic comparison of the impact of different prompts,parameters and inputs for ChatGPT research quality evaluations. 展开更多
关键词 ChatGPT Large Language models LLMs SCIENTOMETRICS Research Assessment
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On large language models safety,security,and privacy:A survey 被引量:1
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作者 Ran Zhang Hong-Wei Li +2 位作者 Xin-Yuan Qian Wen-Bo Jiang Han-Xiao Chen 《Journal of Electronic Science and Technology》 2025年第1期1-21,共21页
The integration of artificial intelligence(AI)technology,particularly large language models(LLMs),has become essential across various sectors due to their advanced language comprehension and generation capabilities.De... The integration of artificial intelligence(AI)technology,particularly large language models(LLMs),has become essential across various sectors due to their advanced language comprehension and generation capabilities.Despite their transformative impact in fields such as machine translation and intelligent dialogue systems,LLMs face significant challenges.These challenges include safety,security,and privacy concerns that undermine their trustworthiness and effectiveness,such as hallucinations,backdoor attacks,and privacy leakage.Previous works often conflated safety issues with security concerns.In contrast,our study provides clearer and more reasonable definitions for safety,security,and privacy within the context of LLMs.Building on these definitions,we provide a comprehensive overview of the vulnerabilities and defense mechanisms related to safety,security,and privacy in LLMs.Additionally,we explore the unique research challenges posed by LLMs and suggest potential avenues for future research,aiming to enhance the robustness and reliability of LLMs in the face of emerging threats. 展开更多
关键词 Large language models Privacy issues Safety issues Security issues
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Mechanism of post cardiac arrest syndrome based on animal models of cardiac arrest
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作者 Halidan ABUDU WANG Yiping +10 位作者 HE Kang LIU Ziquan GUO Liqiong DONG Jinrui Ailijiang KADEER XU Guowu LIU Yanqing MENG Xiangyan CAI Jinxia LI Yongmao FAN Haojun 《中南大学学报(医学版)》 北大核心 2025年第5期731-746,共16页
Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the inju... Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the injury and pathophysiological mechanisms underlying PCAS remain unclear.Experimental animal models are valuable tools for exploring the etiology,pathogenesis,and potential interventions for CA and PCAS.Current CA animal models include electrical induction of ventricular fibrillation(VF),myocardial infarction,high potassium,asphyxia,and hemorrhagic shock.Although these models do not fully replicate the complexity of clinical CA,the mechanistic insights they provide remain highly relevant,including post-CA brain injury(PCABI),post-CA myocardial dysfunction(PAMD),systemic ischaemia/reperfusion injury(IRI),and the persistent precipitating pathology.Summarizing the methods of establishing CA models,the challenges encountered in the modeling process,and the mechanisms of PCAS can provide a foundation for developing standardized CA modeling protocols. 展开更多
关键词 cardiac arrest animal model post cardiac arrest syndrome PATHOPHYSIOLOGY modeling method
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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis
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作者 Li Xu Huiming Xu Changyong Tang 《Neural Regeneration Research》 SCIE CAS 2025年第2期354-365,共12页
Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism rem... Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism remains unknown.Therefore,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic targets.Since most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets astrocytes.These experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum disorders.In this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model choices.In addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials. 展开更多
关键词 AQUAPORIN-4 experimental model neuromyelitis optica spectrum disorder PATHOGENESIS
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High-fidelity Lumped-parameter Thermal Models for Assessing Cooling Techniques of PMSMs in EV Applications 被引量:2
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作者 Dawei Liang Zi Qiang Zhu Ankan Dey 《CES Transactions on Electrical Machines and Systems》 2025年第1期1-14,共14页
This paper presents a high-fidelity lumpedparameter(LP)thermal model(HF-LPTM)for permanent magnet synchronous machines(PMSMs)in electric vehicle(EV)applications,where various cooling techniques are considered,includin... This paper presents a high-fidelity lumpedparameter(LP)thermal model(HF-LPTM)for permanent magnet synchronous machines(PMSMs)in electric vehicle(EV)applications,where various cooling techniques are considered,including frame forced air/liquid cooling,oil jet cooling for endwinding,and rotor shaft cooling.To address the temperature misestimation in the LP thermal modelling due to assumptions of concentrated loss input and uniform heat flows,the developed HF-LPTM introduces two compensation thermal resistances for the winding and PM components,which are analytically derived from the multi-dimensional heat transfer equations and are robust against different load/thermal conditions.As validated by the finite element analysis method and experiments,the conventional LPTMs exhibit significant winding temperature deviations,while the proposed HF-LPTM can accurately predict both the midpoint and average temperatures.The developed HFLPTM is further used to assess the effectiveness of various cooling techniques under different scenarios,i.e.,steady-state thermal states under the rated load condition,and transient temperature profiles under city,freeway,and hybrid(city+freeway)driving cycles.Results indicate that no single cooling technique can maintain both winding and PM temperatures within safety limits.The combination of frame liquid cooling and oil jet cooling for end winding can sufficiently mitigate PMSM thermal stress in EV applications. 展开更多
关键词 Cooling techniques Electric vehicle Lumpedparameter thermal model Permanent magnet synchronous machines Thermal analysis Thermal management
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When Software Security Meets Large Language Models:A Survey 被引量:1
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作者 Xiaogang Zhu Wei Zhou +3 位作者 Qing-Long Han Wanlun Ma Sheng Wen Yang Xiang 《IEEE/CAA Journal of Automatica Sinica》 2025年第2期317-334,共18页
Software security poses substantial risks to our society because software has become part of our life. Numerous techniques have been proposed to resolve or mitigate the impact of software security issues. Among them, ... Software security poses substantial risks to our society because software has become part of our life. Numerous techniques have been proposed to resolve or mitigate the impact of software security issues. Among them, software testing and analysis are two of the critical methods, which significantly benefit from the advancements in deep learning technologies. Due to the successful use of deep learning in software security, recently,researchers have explored the potential of using large language models(LLMs) in this area. In this paper, we systematically review the results focusing on LLMs in software security. We analyze the topics of fuzzing, unit test, program repair, bug reproduction, data-driven bug detection, and bug triage. We deconstruct these techniques into several stages and analyze how LLMs can be used in the stages. We also discuss the future directions of using LLMs in software security, including the future directions for the existing use of LLMs and extensions from conventional deep learning research. 展开更多
关键词 Large language models(LLMs) software analysis software security software testing
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The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT 被引量:1
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作者 Wei Zhou Xiaogang Zhu +4 位作者 Qing-Long Han Lin Li Xiao Chen Sheng Wen Yang Xiang 《IEEE/CAA Journal of Automatica Sinica》 2025年第1期1-26,共26页
ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential sec... ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future directions.Through this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users. 展开更多
关键词 Artificial intelligence(AI) ChatGPT large language models(LLMs) SECURITY
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用于厄尔尼诺-南方涛动(ENSO)研究的海气耦合模式:以对我国三个环流型模式(CGCMs)的评估为例 被引量:1
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作者 张荣华 尹露莹 +9 位作者 高川 王宏娜 刘思颖 智海 陈林 康贤彪 俞永强 宋振亚 吴统文 吴方华 《海洋与湖沼》 北大核心 2025年第3期475-501,共27页
基于数理方程的海气耦合模式是研究厄尔尼诺-南方涛动(El Niño-Southern Oscillation,ENSO)的有效工具。由于ENSO模拟性能强烈地依赖于模式的构建及海气过程的表征,目前已发展了各类复杂程度不同的海气耦合模式,包括中间型耦合模式... 基于数理方程的海气耦合模式是研究厄尔尼诺-南方涛动(El Niño-Southern Oscillation,ENSO)的有效工具。由于ENSO模拟性能强烈地依赖于模式的构建及海气过程的表征,目前已发展了各类复杂程度不同的海气耦合模式,包括中间型耦合模式(Intermediate coupled models,ICMs)、混合型耦合模式(Hybrid coupled models,HCMs)和完整的环流型耦合模式等。其中最为复杂的是基于原始方程组的海气耦合环流模式(Coupled general circulation models,CGCMs),它们均由描述大气和海水运动的大气环流模式(Atmospheric general circulation models,AGCMs)和海洋环流模式(Oceanic general circulation models,OGCMs)所组成,包含了广泛而尽可能详尽的物理过程及参数化方案;采用全变量(一个状态变量可分为气候态部分和年际异常部分)和海气间的完全耦合。早期发展的CGCM常常会出现气候漂移现象,对气候平均态和ENSO模拟等会出现较大的模式误差,为此需要采用通量修正(flux corrections)等方法,以减小平均态模拟的系统性误差;这类模式不仅对计算资源有更高的要求,其调试与优化也面临巨大技术挑战。经过几十年的发展和改进,当前使用的CGCMs已经能够真实地再现与ENSO相关的海气变量年际异常的时空结构及演变,这些在耦合模式国际比较计划第6阶段(Coupled model intercomparison project phase 6,CMIP6)模拟中已得到清晰体现上。目前我国不同科研机构和业务单位已发展了CGCMs,其中较为成熟和广泛应用并有大量成果公开发表的CGCMs包括中国科学院大气物理研究所、自然资源部第一海洋研究所和中国气象局等所研发的CGCM系统。经过长期不懈的努力,目前这些CGCMs无须进行偏差或通量校正已能成功地应用于气候模拟、预测和预估等,展现了其对气候平均态和多尺度气候变率等方面数值模拟的良好性能。例如,这些CGCMs对ENSO现象的表征能力已有极大的改进和提高,已广泛应用于ENSO模拟和预测应用之中。然而,目前基于CGCMs对ENSO的数值模拟和预测仍存在着较大的不确定性和模式间差异性。本文将评估这些CGCMs对ENSO模拟的现状和未来发展方向,指出CGCMs所存在的问题和需要改进之处。这些分析和评估为未来ENSO数值模拟和预测的改进和发展提供了有价值的科学指导。 展开更多
关键词 厄尔尼诺-南方涛动(ENSO) 海气相互作用 耦合环流模式(Cgcms) ENSO模拟性能 模拟偏差和不确定性
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