In order to select the best adsorbant for CO2 sequestration, this study deals the interaction between clay, Triassic sandstone and Jurassic evaporate and CO2. These materials have been used as sorbents. To choose the ...In order to select the best adsorbant for CO2 sequestration, this study deals the interaction between clay, Triassic sandstone and Jurassic evaporate and CO2. These materials have been used as sorbents. To choose the adequate geological layers for sequestration and with minimum risk of leakage, adsorbent characterizations were investigated using X-ray diffraction, SEM and surface area analysis, structural and textural shapes of these materials have been investigated too. The elution chromatography in gaseous phase has been employed to determine the adsorption isotherms of adsorbed CO2 for each adsorbent. Then, the treatment of the experimental data allowed us to compare each CO2/adsorbent couple. The adsorption isotherms were modeled using the Langmir and Freundlich models. A thermodynamic comparison between the different adsorbents will also be provided. Experimental results show that clay and Triassic sandstone have the highest rate of adsorption amount. It has been also found that the Langmuir model is the most appropriate one to describe the phenomenon of CO2 adsorption on clay. However, for the other adsorbents (i.e. Triassic sandstone and Jurassic evaporates) the two-models are adequate.展开更多
Drug development is a complex and time-consuming endeavor that traditionally relies on the experience of drug developers and trial-and-error experimentation[1,2].The advent of artificial intelligence(AI)technologies,p...Drug development is a complex and time-consuming endeavor that traditionally relies on the experience of drug developers and trial-and-error experimentation[1,2].The advent of artificial intelligence(AI)technologies,particularly emerging generative AI and large language model,is reshaping this traditional paradigm,offering new avenues for efficiency,precision,and innovation[3].In this special issue,we present an overview of AI applications across the entire drug development workflow.Topics include novel molecule generation,drug–target and drug–drug interaction network prediction,molecular property optimization,pharmaceutical research,and related areas.展开更多
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established b...The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.展开更多
This study investigates trends in extreme precipitation events(EPEs)across Antarctica from 1979 to 2023,analyzing changes in EPE frequency,intensity,and the proportion of extreme to total precipitation.Using Self-Orga...This study investigates trends in extreme precipitation events(EPEs)across Antarctica from 1979 to 2023,analyzing changes in EPE frequency,intensity,and the proportion of extreme to total precipitation.Using Self-Organizing Map(SOM)techniques,the study distinguishes the contributions from thermodynamic,dynamic,and interaction components in explaining these trends.Positive EPE occurrence trends are observed across the Bellingshausen and Weddell Seas,Dronning Maud Land,and parts of the Southern Ocean,with declines limited to Queen Mary Land.Thermodynamic factors,responsible for 96.0%of the overall trend,are driven by increased water vapor content in polar air masses.Dynamic contributions,representing 10.8%,are linked to a strengthened Amundsen Sea Low(ASL)associated with the Southern Annular Mode(SAM)and Pacific South American(PSA)trends.Interaction effects make a slightly negative contribution(-6.8%)to the overall trend.Variations in water vapor transport and vertical velocity tied to annual 500-hPa geopotential height anomalies further explain EPE trends.These findings provide insight into the atmospheric processes that influence Antarctic EPEs,with implications for understanding the climatic impact on the polar environment.展开更多
The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconci...The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.展开更多
Development of on-chip coherent light sources with desired single-mode operation and straightforward spectral tunability has attracted intense interest due to ever-increasing demand for photonic devices and optoelectr...Development of on-chip coherent light sources with desired single-mode operation and straightforward spectral tunability has attracted intense interest due to ever-increasing demand for photonic devices and optoelectronic integration,but still faces serious challenges.Herein,we propose a facile method to synthesize cesium lead halide(CsPbX3)microstructures with well-defined morphologies,sizes,and constituent element gradient.The scheme is conducted using a chemical vapor deposition(CVD),which is subsequently associated with annealing-assisted solid-solid anion exchange.For the plate-shaped structures,the controllability on the cross-sectional dimension enables to precisely modulate the lasing modes,thus achieving single-mode operation;while tuning the stoichiometric of the halogen anion components in the plate-shaped CsPbI_(x)Br_(3−x) alloy samples,the lasing wavelengths are straightforwardly varied to span the entire visible spectrum.By comparison,the experimental scheme on synthesizing alloyed CsPbI_(x)Br_(3−x) perovskites is conducted using an in-situ approach,thereby achieving precise modulation of bandgap-controlled microlasers by controlling the reaction time.Such laser properties like controllable microcavity modes and broad stoichiometry-dependent tunability of light-emitting/lasing colors,associated with the facile synthesizing method of monocrystalline CsPbI_(x)Br_(3−x) structures,make lead halide perovskites ideal materials for the development of wavelength-controlled microlasers toward practical photonic integration.展开更多
The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield...The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield tunneling remains inadequate.The analytical solution for calculating the deformation of the ground and existing tunnel induced by overlapped curved shield tunneling is derived by the Mirror theory,Mindlin solution and Euler-Bernoulli-Pasternak model,subsequently validated through both finite element simulation and field monitoring.It is determined that the overcutting plays a crucial role in the ground settlement resulting from curved shield tunneling compared to straight shield tunneling.The longitudinal settlement distribution can be categorized into five areas,with the area near the tunnel surface experiencing the most dramatic settlement changes.The deformation of the existing tunnel varies most significantly with turning radius compared to tunnel clearance and grouting pressure,especially when the turning radius is less than 30 times the tunnel diameter.The tunnel crown exhibits larger displacement than the tunnel bottom,resulting in a distinctive‘vertical egg'shape.Furthermore,an optimized overcutting mode is proposed,involving precise control of the extension speed and angular velocity of the overcutting cutter,which effectively mitigates ground deformation,ensuring the protection of the existing tunnel during the construction.展开更多
To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D lea...To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D leader-following cooperative interception guidance law.First,in the LOS direction of the leader,an impact time-controlled guidance law is derived based on the fixed-time stability theory,which enables the leader to complete the interception task at a prespecified impact time.Next,in the LOS direction of the followers,by introducing a time consensus tracking error function,a fixed-time consensus tracking guidance law is investigated to guarantee the consensus tracking convergence of the time-to-go.Then,in the direction normal to the LOS,by combining the designed global integral sliding mode surface and the second-order Sliding Mode Control(SMC)theory,an innovative 3D LOS-angle-constrained interception guidance law is developed,which eliminates the reaching phase in the traditional sliding mode guidance laws and effectively saves energy consumption.Moreover,it effectively suppresses the chattering phenomenon while avoiding the singularity issue,and compensates for unknown interference caused by target maneuvering online,making it convenient for practical engineering applications.Finally,theoretical proof analysis and multiple sets of numerical simulation results verify the effectiveness,superiority,and robustness of the investigated guidance law.展开更多
Frequent glacier-related watershed geohazard chains are causing severe damage to life and infrastructure,reported consistently from the Eastern Himalayan Syntaxis.This paper presents a systematic method for researchin...Frequent glacier-related watershed geohazard chains are causing severe damage to life and infrastructure,reported consistently from the Eastern Himalayan Syntaxis.This paper presents a systematic method for researching geohazard,from regional to individual scale.The methodology includes the establishment of geological chain inventories,discrimination of geohazard chain modes,analyses of dynamics and dam breaches,and risk assessments.The following results were obtained:(1)In the downstream of Yarlung Zangbo River,175 sites were identified as high-risk for river blockage disasters,indicating the development of watershed geohazards.Five geohazard chain modes were summarized by incorporating geomorphological characteristics,historical events,landslide zoning,and materials.The risk areas of typical hazard were identified and assessed using InSAR data.(2)Glacier-related watershed geohazard chains are significantly different from traditional landslides.A detailed inversion analysis was conducted on the massive rock-ice avalanche in the Sedongpu gully in 2021.This particular event lasted roughly 300 seconds,with a maximum flow velocity of 77.2 m/s and a maximum flow height of 93 meters.By scrutinizing the dynamic processes and mechanical characteristics,mobility stages and phase transitions can be divided into four stages.(3)Watershed geohazard chains tend to block rivers.The peak breach discharge of the Yigong Landslide reached 12.4×10^(4) m^(3)/s,which is 36 times the volume of the seasonal flood discharge in the Yigong River.Megafloods caused by landslide dam breaches have significantly shaped the geomorphology.This study offers insights into disaster patterns and the multistaged movement characteristics of glacier-related watershed geohazard chains,providing a comprehensive method for investigations and assessments in glacial regions.展开更多
In integrated circuit(IC)manufacturing,fast,nondestructive,and precise detection of defects in patterned wafers,realized by bright-field microscopy,is one of the critical factors for ensuring the final performance and...In integrated circuit(IC)manufacturing,fast,nondestructive,and precise detection of defects in patterned wafers,realized by bright-field microscopy,is one of the critical factors for ensuring the final performance and yields of chips.With the critical dimensions of IC nanostructures continuing to shrink,directly imaging or classifying deep-subwavelength defects by bright-field microscopy is challenging due to the well-known diffraction barrier,the weak scattering effect,and the faint correlation between the scattering cross-section and the defect morphology.Herein,we propose an optical far-field inspection method based on the form-birefringence scattering imaging of the defective nanostructure,which can identify and classify various defects without requiring optical super-resolution.The technique is built upon the principle of breaking the optical form birefringence of the original periodic nanostructures by the defect perturbation under the anisotropic illumination modes,such as the orthogonally polarized plane waves,then combined with the high-order difference of far-field images.We validated the feasibility and effectiveness of the proposed method in detecting deep subwavelength defects through rigid vector imaging modeling and optical detection experiments of various defective nanostructures based on polarization microscopy.On this basis,an intelligent classification algorithm for typical patterned defects based on a dual-channel AlexNet neural network has been proposed,stabilizing the classification accuracy ofλ/16-sized defects with highly similar features at more than 90%.The strong classification capability of the two-channel network on typical patterned defects can be attributed to the high-order difference image and its transverse gradient being used as the network’s input,which highlights the polarization modulation difference between different patterned defects more significantly than conventional bright-field microscopy results.This work will provide a new but easy-to-operate method for detecting and classifying deep-subwavelength defects in patterned wafers or photomasks,which thus endows current online inspection equipment with more missions in advanced IC manufacturing.展开更多
This study investigates the influence of major climatic modes on the interannual variability of the annual minimum extent of Antarctic sea ice.It shows that the Southern Annular Mode(SAM),the Indian Ocean Dipole(IOD),...This study investigates the influence of major climatic modes on the interannual variability of the annual minimum extent of Antarctic sea ice.It shows that the Southern Annular Mode(SAM),the Indian Ocean Dipole(IOD),and the El Niño-Southern Oscillation(ENSO),along with the total sea ice condition during the preceding spring,serve as precursor signals of February sea ice extent(SIE).These climate modes interact,energizing the Pacific-South American pattern(PSA),which deepens and shifts the Amundsen Sea Low(ASL)westward in spring.This pattern generates a dipole sea ice anomaly characterized by an increase in sea ice in the northern Ross Sea but a decrease in ice in the Bellingshausen and northern Weddell Seas.However,as the season transitions into summer,the ASL exerts a pronounced delayed effect,contributing to widespread sea ice loss across West Antarctica.Strong southerly winds on the western flank of the ASL push sea ice away from the inner Ross Sea,exposing coastal waters that absorb solar radiation,thereby accelerating ice melt through positive ice-albedo feedback.Simultaneously,northwesterly winds on the eastern flank transport warm air toward the Bellingshausen and northern Weddell Seas,intensifying ice loss in these regions.Furthermore,the active PSA is accompanied by a tripole sea surface temperature pattern characterized by warming in the Weddell Sea,which promotes continued ice melt.The co-occurrence of an exceptionally positive SAM,a La Niña,and a strong negative IOD during spring 2022,combined with lower-than-normal total spring SIE,ultimately contributed to the record-low Antarctic SIE observed in February 2023.展开更多
In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The ...In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The microstructure and solidification kinetics of the two as-cast grades were in situ observed by high temperature confocal laser scanning microscopy(HT-CLSM).There are significant differences in the as-cast microstructures of the two 316L stainless steel compositions.In L-316L steel,ferrite morphology appears as the short rods with a ferrite content of 6.98%,forming a dual-phase microstructure consisting of austenite and ferrite.Conversely,in H-316L steel,the ferrite appears as discontinuous network structures with a content of 4.41%,forming a microstructure composed of austenite and sigma(σ)phase.The alloying elements in H-316L steel exhibit a complex distribution,with Ni and Mo enriching at the austenite grain boundaries.HT-CLSM experiments provide the real-time observation of the solidification processes of both 316L specimens and reveal distinct solidification modes:L-316L steel solidifies in an FA mode,whereas H-316L steel solidifies in an AF mode.These differences result in ferrite and austenite predominantly serving as the nucleation and growth phases,respectively.The solidification mode observed by experiments is similar to the thermodynamic calculation results.The L-316L steel solidified in the FA mode and showed minimal element segregation,which lead to a direct transformation of ferrite to austenite phase(δ→γ)during phase transformation after solidification.Besides,the H-316L steel solidified in the AF mode and showed severe element segregation,which lead to Mo enrichment at grain boundaries and transformation of ferrite into sigma and austenite phases through the eutectoid reaction(δ→σ+γ).展开更多
A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states...A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states.The experimental results indicate that the dip angle of structural plane(θ)and the intermediate principal stress(σ2)have an important influence on the peak strength,cracking mode,and rockburst severity.The peak strength exhibits a first increase and then decrease as a function ofσ2 for a constantθ.However,whenσ2 is constant,the maximum peak strength is obtained atθof 90°,and the minimum peak strength is obtained atθof 30°or 45°.For the case of an inclined structural plane,the crack type at the tips of structural plane transforms from a mix of wing and anti-wing cracks to wing cracks with an increase inσ2,while the crack type around the tips of structural plane is always anti-wing cracks for the vertical structural plane,accompanied by a series of tensile cracks besides.The specimens with structural plane do not undergo slabbing failure regardless ofθ,and always exhibit composite tensile-shear failure whatever theσ2 value is.With an increase inσ2 andθ,the intensity of the rockburst is consistent with the tendency of the peak strength.By analyzing the relationship between the cohesion(c),internal friction angle(φ),andθin sandstone specimens,we incorporateθinto the true triaxial unloading strength criterion,and propose a modified linear Mogi-Coulomb criterion.Moreover,the crack propagation mechanism at the tips of structural plane,and closure degree of the structural plane under true triaxial unloading conditions are also discussed and summarized.This study provides theoretical guidance for stability assessment of surrounding rocks containing geological structures in deep complex stress environments.展开更多
This paper presents the design of an asymmetrically variable wingtip anhedral angles morphing aircraft,inspired by biomimetic mechanisms,to enhance lateral maneuver capability.Firstly,we establish a lateral dynamic mo...This paper presents the design of an asymmetrically variable wingtip anhedral angles morphing aircraft,inspired by biomimetic mechanisms,to enhance lateral maneuver capability.Firstly,we establish a lateral dynamic model considering additional forces and moments resulting during the morphing process,and convert it into a Multiple Input Multiple Output(MIMO)virtual control system by importing virtual inputs.Secondly,a classical dynamics inversion controller is designed for the outer-loop system.A new Global Fast Terminal Incremental Sliding Mode Controller(NDO-GFTISMC)is proposed for the inner-loop system,in which an adaptive law is implemented to weaken control surface chattering,and a Nonlinear Disturbance Observer(NDO)is integrated to compensate for unknown disturbances.The whole control system is proven semiglobally uniformly ultimately bounded based on the multi-Lyapunov function method.Furthermore,we consider tracking errors and self-characteristics of actuators,a quadratic programmingbased dynamic control allocation law is designed,which allocates virtual control inputs to the asymmetrically deformed wingtip and rudder.Actuator dynamic models are incorporated to ensure physical realizability of designed allocation law.Finally,comparative experimental results validate the effectiveness of the designed control system and control allocation law.The NDO-GFTISMC features faster convergence,stronger robustness,and 81.25%and 75.0%reduction in maximum state tracking error under uncertainty compared to the Incremental Nonlinear Dynamic Inversion Controller based on NDO(NDO-INDI)and Incremental Sliding Mode Controller based on NDO(NDO-ISMC),respectively.The design of the morphing aircraft significantly enhances lateral maneuver capability,maintaining a substantial control margin during lateral maneuvering,reducing the burden of the rudder surface,and effectively solving the actuator saturation problem of traditional aircraft during lateral maneuvering.展开更多
Due to scale effects,micromechanical resonators offer an excellent platform for investigating the intrinsic mechanisms of nonlinear dynamical phenomena and their potential applications.This review focuses on mode-coup...Due to scale effects,micromechanical resonators offer an excellent platform for investigating the intrinsic mechanisms of nonlinear dynamical phenomena and their potential applications.This review focuses on mode-coupled micromechanical resonators,highlighting the latest advancements in four key areas:internal resonance,synchronization,frequency combs,and mode localization.The origin,development,and potential applications of each of these dynamic phenomena within mode-coupled micromechanical systems are investigated,with the goal of inspiring new ideas and directions for researchers in this field.展开更多
Understanding the dynamic responses of hard rocks is crucial during deep mining and tunneling activities and when constructing nuclear waste repositories. However, the response of deep massive rocks with openings of d...Understanding the dynamic responses of hard rocks is crucial during deep mining and tunneling activities and when constructing nuclear waste repositories. However, the response of deep massive rocks with openings of different shapes and orientations to dynamic loading is not well understood. Therefore, this study investigates the dynamic responses of hard rocks of deep underground excavation activities. Split Hopkins Pressure Bar (SHPB) tests on granite with holes of different shapes (rectangle, circle, vertical ellipse (elliptical short (ES) axis parallel to the impact load direction), and horizontal ellipse (elliptical long (EL) axis parallel to the impact load direction)) were carried out. The influence of hole shape and location on the dynamic responses was analyzed to reveal the rocks' dynamic strengths and cracking characteristics. We used the ResNet18 (convolutional neural network-based) network to recognize crack types using high-speed photographs. Moreover, a prediction model for the stress-strain response of rocks with different openings was established using Deep Neural Network (DNN). The results show that the dynamic strengths of the granite with EL and ES holes are the highest and lowest, respectively. The strength-weakening coefficient decreases first and then increases with an increase of thickness-span ratio (h/L). The weakening of the granite with ES holes is the most obvious. The ResNet18 network can improve the analyzing efficiency of the cracking mechanism, and the trained model's recognition accuracy reaches 99%. Finally, the dynamic stress-strain prediction model can predict the complete stress-strain curve well, with an accuracy above 85%.展开更多
In this paper, we have demonstrated an Er-doped ultrafast laser with a single mode fiber-gradient index multimode fiber-single mode fiber(SMF-GIMF-SMF, SMS) structure as saturable absorber(SA), which can generate not ...In this paper, we have demonstrated an Er-doped ultrafast laser with a single mode fiber-gradient index multimode fiber-single mode fiber(SMF-GIMF-SMF, SMS) structure as saturable absorber(SA), which can generate not only stable single-pulse state, but also special mode-locked pulses with the characteristics of high energy and noisy behaviors at proper pump power and cavity polarization state. In addition, we have deeply investigated the real-time spectral evolutions of the mode-locked pulses through the dispersive Fourier transformation(DFT) technique. It can be found that the pulse regime can actually consist of a lot of small noise pulses with randomly varying intensities. We believe that these results will further enrich the nonlinear dynamical processes in the ultrafast lasers.展开更多
文摘In order to select the best adsorbant for CO2 sequestration, this study deals the interaction between clay, Triassic sandstone and Jurassic evaporate and CO2. These materials have been used as sorbents. To choose the adequate geological layers for sequestration and with minimum risk of leakage, adsorbent characterizations were investigated using X-ray diffraction, SEM and surface area analysis, structural and textural shapes of these materials have been investigated too. The elution chromatography in gaseous phase has been employed to determine the adsorption isotherms of adsorbed CO2 for each adsorbent. Then, the treatment of the experimental data allowed us to compare each CO2/adsorbent couple. The adsorption isotherms were modeled using the Langmir and Freundlich models. A thermodynamic comparison between the different adsorbents will also be provided. Experimental results show that clay and Triassic sandstone have the highest rate of adsorption amount. It has been also found that the Langmuir model is the most appropriate one to describe the phenomenon of CO2 adsorption on clay. However, for the other adsorbents (i.e. Triassic sandstone and Jurassic evaporates) the two-models are adequate.
文摘Drug development is a complex and time-consuming endeavor that traditionally relies on the experience of drug developers and trial-and-error experimentation[1,2].The advent of artificial intelligence(AI)technologies,particularly emerging generative AI and large language model,is reshaping this traditional paradigm,offering new avenues for efficiency,precision,and innovation[3].In this special issue,we present an overview of AI applications across the entire drug development workflow.Topics include novel molecule generation,drug–target and drug–drug interaction network prediction,molecular property optimization,pharmaceutical research,and related areas.
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
文摘The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.
基金supported by the National Key R&D Program of China(2022YFE0106300)Norges Forskningsråd(328886).
文摘This study investigates trends in extreme precipitation events(EPEs)across Antarctica from 1979 to 2023,analyzing changes in EPE frequency,intensity,and the proportion of extreme to total precipitation.Using Self-Organizing Map(SOM)techniques,the study distinguishes the contributions from thermodynamic,dynamic,and interaction components in explaining these trends.Positive EPE occurrence trends are observed across the Bellingshausen and Weddell Seas,Dronning Maud Land,and parts of the Southern Ocean,with declines limited to Queen Mary Land.Thermodynamic factors,responsible for 96.0%of the overall trend,are driven by increased water vapor content in polar air masses.Dynamic contributions,representing 10.8%,are linked to a strengthened Amundsen Sea Low(ASL)associated with the Southern Annular Mode(SAM)and Pacific South American(PSA)trends.Interaction effects make a slightly negative contribution(-6.8%)to the overall trend.Variations in water vapor transport and vertical velocity tied to annual 500-hPa geopotential height anomalies further explain EPE trends.These findings provide insight into the atmospheric processes that influence Antarctic EPEs,with implications for understanding the climatic impact on the polar environment.
基金the National Natural Science:Foundation of China(52375370)the Open Project of Salt Lake Chemical Engineering Research Complex,Qinghai University(2023-DXSSKF-Z02)+2 种基金the Nat-ural Science Foundation of Shanxi(202103021224049)GDAS Projects of International cooperation platform of Sci-ence and Technology(2022GDASZH-2022010203-003)Guangdong province Science and Technology Plan Projects(2023B1212060045).
文摘The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.
基金supported by the National Natural Science Foundation of China(No.12374257)。
文摘Development of on-chip coherent light sources with desired single-mode operation and straightforward spectral tunability has attracted intense interest due to ever-increasing demand for photonic devices and optoelectronic integration,but still faces serious challenges.Herein,we propose a facile method to synthesize cesium lead halide(CsPbX3)microstructures with well-defined morphologies,sizes,and constituent element gradient.The scheme is conducted using a chemical vapor deposition(CVD),which is subsequently associated with annealing-assisted solid-solid anion exchange.For the plate-shaped structures,the controllability on the cross-sectional dimension enables to precisely modulate the lasing modes,thus achieving single-mode operation;while tuning the stoichiometric of the halogen anion components in the plate-shaped CsPbI_(x)Br_(3−x) alloy samples,the lasing wavelengths are straightforwardly varied to span the entire visible spectrum.By comparison,the experimental scheme on synthesizing alloyed CsPbI_(x)Br_(3−x) perovskites is conducted using an in-situ approach,thereby achieving precise modulation of bandgap-controlled microlasers by controlling the reaction time.Such laser properties like controllable microcavity modes and broad stoichiometry-dependent tunability of light-emitting/lasing colors,associated with the facile synthesizing method of monocrystalline CsPbI_(x)Br_(3−x) structures,make lead halide perovskites ideal materials for the development of wavelength-controlled microlasers toward practical photonic integration.
基金financially supported by the National Natural Science Foundation of China(Grant No.52078334)the National Key Research and Development Program of China(Grant No.2017YFC0805402)the Tianjin Research Innovation Project for Postgraduate Students(Grant No.2021YJSB141).
文摘The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield tunneling remains inadequate.The analytical solution for calculating the deformation of the ground and existing tunnel induced by overlapped curved shield tunneling is derived by the Mirror theory,Mindlin solution and Euler-Bernoulli-Pasternak model,subsequently validated through both finite element simulation and field monitoring.It is determined that the overcutting plays a crucial role in the ground settlement resulting from curved shield tunneling compared to straight shield tunneling.The longitudinal settlement distribution can be categorized into five areas,with the area near the tunnel surface experiencing the most dramatic settlement changes.The deformation of the existing tunnel varies most significantly with turning radius compared to tunnel clearance and grouting pressure,especially when the turning radius is less than 30 times the tunnel diameter.The tunnel crown exhibits larger displacement than the tunnel bottom,resulting in a distinctive‘vertical egg'shape.Furthermore,an optimized overcutting mode is proposed,involving precise control of the extension speed and angular velocity of the overcutting cutter,which effectively mitigates ground deformation,ensuring the protection of the existing tunnel during the construction.
文摘To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D leader-following cooperative interception guidance law.First,in the LOS direction of the leader,an impact time-controlled guidance law is derived based on the fixed-time stability theory,which enables the leader to complete the interception task at a prespecified impact time.Next,in the LOS direction of the followers,by introducing a time consensus tracking error function,a fixed-time consensus tracking guidance law is investigated to guarantee the consensus tracking convergence of the time-to-go.Then,in the direction normal to the LOS,by combining the designed global integral sliding mode surface and the second-order Sliding Mode Control(SMC)theory,an innovative 3D LOS-angle-constrained interception guidance law is developed,which eliminates the reaching phase in the traditional sliding mode guidance laws and effectively saves energy consumption.Moreover,it effectively suppresses the chattering phenomenon while avoiding the singularity issue,and compensates for unknown interference caused by target maneuvering online,making it convenient for practical engineering applications.Finally,theoretical proof analysis and multiple sets of numerical simulation results verify the effectiveness,superiority,and robustness of the investigated guidance law.
基金supported by the National Natural Science Foundation of China(Nos.U2244227,U2244226,42177172)the National Key R&D Program of China(No.2022YFC3004301)China Geological Survey Project(No.DD20230538)。
文摘Frequent glacier-related watershed geohazard chains are causing severe damage to life and infrastructure,reported consistently from the Eastern Himalayan Syntaxis.This paper presents a systematic method for researching geohazard,from regional to individual scale.The methodology includes the establishment of geological chain inventories,discrimination of geohazard chain modes,analyses of dynamics and dam breaches,and risk assessments.The following results were obtained:(1)In the downstream of Yarlung Zangbo River,175 sites were identified as high-risk for river blockage disasters,indicating the development of watershed geohazards.Five geohazard chain modes were summarized by incorporating geomorphological characteristics,historical events,landslide zoning,and materials.The risk areas of typical hazard were identified and assessed using InSAR data.(2)Glacier-related watershed geohazard chains are significantly different from traditional landslides.A detailed inversion analysis was conducted on the massive rock-ice avalanche in the Sedongpu gully in 2021.This particular event lasted roughly 300 seconds,with a maximum flow velocity of 77.2 m/s and a maximum flow height of 93 meters.By scrutinizing the dynamic processes and mechanical characteristics,mobility stages and phase transitions can be divided into four stages.(3)Watershed geohazard chains tend to block rivers.The peak breach discharge of the Yigong Landslide reached 12.4×10^(4) m^(3)/s,which is 36 times the volume of the seasonal flood discharge in the Yigong River.Megafloods caused by landslide dam breaches have significantly shaped the geomorphology.This study offers insights into disaster patterns and the multistaged movement characteristics of glacier-related watershed geohazard chains,providing a comprehensive method for investigations and assessments in glacial regions.
基金funded by National Natural Science Foundation of China(Grant Nos.52130504,52305577,and 52175509)the Key Research and Development Plan of Hubei Province(Grant No.2022BAA013)+4 种基金the Major Program(JD)of Hubei Province(Grant No.2023BAA008-2)the Interdisciplinary Research Program of Huazhong University of Science and Technology(2023JCYJ047)the Innovation Project of Optics Valley Laboratory(Grant No.OVL2023PY003)the Postdoctoral Fellowship Program(Grade B)of China Postdoctoral Science Foundation(Grant No.GZB20230244)the fellowship from the China Postdoctoral Science Foundation(2024M750995)。
文摘In integrated circuit(IC)manufacturing,fast,nondestructive,and precise detection of defects in patterned wafers,realized by bright-field microscopy,is one of the critical factors for ensuring the final performance and yields of chips.With the critical dimensions of IC nanostructures continuing to shrink,directly imaging or classifying deep-subwavelength defects by bright-field microscopy is challenging due to the well-known diffraction barrier,the weak scattering effect,and the faint correlation between the scattering cross-section and the defect morphology.Herein,we propose an optical far-field inspection method based on the form-birefringence scattering imaging of the defective nanostructure,which can identify and classify various defects without requiring optical super-resolution.The technique is built upon the principle of breaking the optical form birefringence of the original periodic nanostructures by the defect perturbation under the anisotropic illumination modes,such as the orthogonally polarized plane waves,then combined with the high-order difference of far-field images.We validated the feasibility and effectiveness of the proposed method in detecting deep subwavelength defects through rigid vector imaging modeling and optical detection experiments of various defective nanostructures based on polarization microscopy.On this basis,an intelligent classification algorithm for typical patterned defects based on a dual-channel AlexNet neural network has been proposed,stabilizing the classification accuracy ofλ/16-sized defects with highly similar features at more than 90%.The strong classification capability of the two-channel network on typical patterned defects can be attributed to the high-order difference image and its transverse gradient being used as the network’s input,which highlights the polarization modulation difference between different patterned defects more significantly than conventional bright-field microscopy results.This work will provide a new but easy-to-operate method for detecting and classifying deep-subwavelength defects in patterned wafers or photomasks,which thus endows current online inspection equipment with more missions in advanced IC manufacturing.
基金supported by the National Natural Science Foundation of China (Grant Nos.42288101 and 42375045)
文摘This study investigates the influence of major climatic modes on the interannual variability of the annual minimum extent of Antarctic sea ice.It shows that the Southern Annular Mode(SAM),the Indian Ocean Dipole(IOD),and the El Niño-Southern Oscillation(ENSO),along with the total sea ice condition during the preceding spring,serve as precursor signals of February sea ice extent(SIE).These climate modes interact,energizing the Pacific-South American pattern(PSA),which deepens and shifts the Amundsen Sea Low(ASL)westward in spring.This pattern generates a dipole sea ice anomaly characterized by an increase in sea ice in the northern Ross Sea but a decrease in ice in the Bellingshausen and northern Weddell Seas.However,as the season transitions into summer,the ASL exerts a pronounced delayed effect,contributing to widespread sea ice loss across West Antarctica.Strong southerly winds on the western flank of the ASL push sea ice away from the inner Ross Sea,exposing coastal waters that absorb solar radiation,thereby accelerating ice melt through positive ice-albedo feedback.Simultaneously,northwesterly winds on the eastern flank transport warm air toward the Bellingshausen and northern Weddell Seas,intensifying ice loss in these regions.Furthermore,the active PSA is accompanied by a tripole sea surface temperature pattern characterized by warming in the Weddell Sea,which promotes continued ice melt.The co-occurrence of an exceptionally positive SAM,a La Niña,and a strong negative IOD during spring 2022,combined with lower-than-normal total spring SIE,ultimately contributed to the record-low Antarctic SIE observed in February 2023.
基金support of the Research Project Supported by Shanxi Scholarship Council of China(2022-040)"Chunhui Plan"Collaborative Research Project by the Ministry of Education of China(HZKY20220507)+2 种基金National Natural Science Foundation of China(52104338)Applied Fundamental Research Programs of Shanxi Province(202303021221036)Shandong Postdoctoral Science Foundation(SDCX-ZG-202303027,SDBX2023054).
文摘In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The microstructure and solidification kinetics of the two as-cast grades were in situ observed by high temperature confocal laser scanning microscopy(HT-CLSM).There are significant differences in the as-cast microstructures of the two 316L stainless steel compositions.In L-316L steel,ferrite morphology appears as the short rods with a ferrite content of 6.98%,forming a dual-phase microstructure consisting of austenite and ferrite.Conversely,in H-316L steel,the ferrite appears as discontinuous network structures with a content of 4.41%,forming a microstructure composed of austenite and sigma(σ)phase.The alloying elements in H-316L steel exhibit a complex distribution,with Ni and Mo enriching at the austenite grain boundaries.HT-CLSM experiments provide the real-time observation of the solidification processes of both 316L specimens and reveal distinct solidification modes:L-316L steel solidifies in an FA mode,whereas H-316L steel solidifies in an AF mode.These differences result in ferrite and austenite predominantly serving as the nucleation and growth phases,respectively.The solidification mode observed by experiments is similar to the thermodynamic calculation results.The L-316L steel solidified in the FA mode and showed minimal element segregation,which lead to a direct transformation of ferrite to austenite phase(δ→γ)during phase transformation after solidification.Besides,the H-316L steel solidified in the AF mode and showed severe element segregation,which lead to Mo enrichment at grain boundaries and transformation of ferrite into sigma and austenite phases through the eutectoid reaction(δ→σ+γ).
基金supports from the National Natural Science Foundation of China (Grant Nos.52004143 and 52374095)the open fund for the Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines (Grant No.SKLMRDPC21KF06).
文摘A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states.The experimental results indicate that the dip angle of structural plane(θ)and the intermediate principal stress(σ2)have an important influence on the peak strength,cracking mode,and rockburst severity.The peak strength exhibits a first increase and then decrease as a function ofσ2 for a constantθ.However,whenσ2 is constant,the maximum peak strength is obtained atθof 90°,and the minimum peak strength is obtained atθof 30°or 45°.For the case of an inclined structural plane,the crack type at the tips of structural plane transforms from a mix of wing and anti-wing cracks to wing cracks with an increase inσ2,while the crack type around the tips of structural plane is always anti-wing cracks for the vertical structural plane,accompanied by a series of tensile cracks besides.The specimens with structural plane do not undergo slabbing failure regardless ofθ,and always exhibit composite tensile-shear failure whatever theσ2 value is.With an increase inσ2 andθ,the intensity of the rockburst is consistent with the tendency of the peak strength.By analyzing the relationship between the cohesion(c),internal friction angle(φ),andθin sandstone specimens,we incorporateθinto the true triaxial unloading strength criterion,and propose a modified linear Mogi-Coulomb criterion.Moreover,the crack propagation mechanism at the tips of structural plane,and closure degree of the structural plane under true triaxial unloading conditions are also discussed and summarized.This study provides theoretical guidance for stability assessment of surrounding rocks containing geological structures in deep complex stress environments.
基金supported by the National Natural Science Foundation of China(Nos.62103052 and No.52175214)。
文摘This paper presents the design of an asymmetrically variable wingtip anhedral angles morphing aircraft,inspired by biomimetic mechanisms,to enhance lateral maneuver capability.Firstly,we establish a lateral dynamic model considering additional forces and moments resulting during the morphing process,and convert it into a Multiple Input Multiple Output(MIMO)virtual control system by importing virtual inputs.Secondly,a classical dynamics inversion controller is designed for the outer-loop system.A new Global Fast Terminal Incremental Sliding Mode Controller(NDO-GFTISMC)is proposed for the inner-loop system,in which an adaptive law is implemented to weaken control surface chattering,and a Nonlinear Disturbance Observer(NDO)is integrated to compensate for unknown disturbances.The whole control system is proven semiglobally uniformly ultimately bounded based on the multi-Lyapunov function method.Furthermore,we consider tracking errors and self-characteristics of actuators,a quadratic programmingbased dynamic control allocation law is designed,which allocates virtual control inputs to the asymmetrically deformed wingtip and rudder.Actuator dynamic models are incorporated to ensure physical realizability of designed allocation law.Finally,comparative experimental results validate the effectiveness of the designed control system and control allocation law.The NDO-GFTISMC features faster convergence,stronger robustness,and 81.25%and 75.0%reduction in maximum state tracking error under uncertainty compared to the Incremental Nonlinear Dynamic Inversion Controller based on NDO(NDO-INDI)and Incremental Sliding Mode Controller based on NDO(NDO-ISMC),respectively.The design of the morphing aircraft significantly enhances lateral maneuver capability,maintaining a substantial control margin during lateral maneuvering,reducing the burden of the rudder surface,and effectively solving the actuator saturation problem of traditional aircraft during lateral maneuvering.
基金supported by the National Key Research and Development Program of China(No.2022YFB3203600)the National Natural Science Foundation of China(Nos.12202355,12132013,and 12172323)the Zhejiang Provincial Natural Science Foundation of China(No.LZ22A020003)。
文摘Due to scale effects,micromechanical resonators offer an excellent platform for investigating the intrinsic mechanisms of nonlinear dynamical phenomena and their potential applications.This review focuses on mode-coupled micromechanical resonators,highlighting the latest advancements in four key areas:internal resonance,synchronization,frequency combs,and mode localization.The origin,development,and potential applications of each of these dynamic phenomena within mode-coupled micromechanical systems are investigated,with the goal of inspiring new ideas and directions for researchers in this field.
基金funding support from the National Natural Science Foundation of China(Grant No.52374119)the opening fund of State Key Laboratory of Coal Mine Disaster Dynamics and Control(Grant No.2011DA105827-FW202209)the opening fund of State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure,East China Jiaotong University(Grant No.HJGZ2023103).
文摘Understanding the dynamic responses of hard rocks is crucial during deep mining and tunneling activities and when constructing nuclear waste repositories. However, the response of deep massive rocks with openings of different shapes and orientations to dynamic loading is not well understood. Therefore, this study investigates the dynamic responses of hard rocks of deep underground excavation activities. Split Hopkins Pressure Bar (SHPB) tests on granite with holes of different shapes (rectangle, circle, vertical ellipse (elliptical short (ES) axis parallel to the impact load direction), and horizontal ellipse (elliptical long (EL) axis parallel to the impact load direction)) were carried out. The influence of hole shape and location on the dynamic responses was analyzed to reveal the rocks' dynamic strengths and cracking characteristics. We used the ResNet18 (convolutional neural network-based) network to recognize crack types using high-speed photographs. Moreover, a prediction model for the stress-strain response of rocks with different openings was established using Deep Neural Network (DNN). The results show that the dynamic strengths of the granite with EL and ES holes are the highest and lowest, respectively. The strength-weakening coefficient decreases first and then increases with an increase of thickness-span ratio (h/L). The weakening of the granite with ES holes is the most obvious. The ResNet18 network can improve the analyzing efficiency of the cracking mechanism, and the trained model's recognition accuracy reaches 99%. Finally, the dynamic stress-strain prediction model can predict the complete stress-strain curve well, with an accuracy above 85%.
基金supported by the Guangdong Basic and Applied Basic Research Foundation (No.2023A1515010093)the Shenzhen Fundamental Research Program (Stable Support Plan Program)(Nos.JCYJ20220809170611004, 20231121110828001 and 20231121113641002)the National Taipei University of Technology-Shenzhen University Joint Research Program (No.2024001)。
文摘In this paper, we have demonstrated an Er-doped ultrafast laser with a single mode fiber-gradient index multimode fiber-single mode fiber(SMF-GIMF-SMF, SMS) structure as saturable absorber(SA), which can generate not only stable single-pulse state, but also special mode-locked pulses with the characteristics of high energy and noisy behaviors at proper pump power and cavity polarization state. In addition, we have deeply investigated the real-time spectral evolutions of the mode-locked pulses through the dispersive Fourier transformation(DFT) technique. It can be found that the pulse regime can actually consist of a lot of small noise pulses with randomly varying intensities. We believe that these results will further enrich the nonlinear dynamical processes in the ultrafast lasers.
