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Balanced Optimization of Dimensional Accuracy and Printing Efficiency in FDM Based on Data-Driven Modeling
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作者 Liu Changhui Li Hao +5 位作者 Yu Chunlong Liao Xueru Liu Xiaojia Sun Jianzhi Tang Qirong Yu Min 《Additive Manufacturing Frontiers》 2025年第2期97-110,共14页
Additive manufacturing(AM),particularly fused deposition modeling(FDM),has emerged as a transformative technology in modern manufacturing processes.The dimensional accuracy of FDM-printed parts is crucial for ensuring... Additive manufacturing(AM),particularly fused deposition modeling(FDM),has emerged as a transformative technology in modern manufacturing processes.The dimensional accuracy of FDM-printed parts is crucial for ensuring their functional integrity and performance.To achieve sustainable manufacturing in FDM,it is necessary to optimize the print quality and time efficiency concurrently.However,owing to the complex interactions of printing parameters,achieving a balanced optimization of both remains challenging.This study examines four key factors affecting dimensional accuracy and print time:printing speed,layer thickness,nozzle temperature,and bed temperature.Fifty parameter sets were generated using enhanced Latin hypercube sampling.A whale optimization algorithm(WOA)-enhanced support vector regression(SVR)model was developed to predict dimen-sional errors and print time effectively,with non-dominated sorting genetic algorithm Ⅲ(NSGA-Ⅲ)utilized for multi-objective optimization.The technique for Order Preference by Similarity to Ideal Solution(TOPSIS)was applied to select a balanced solution from the Pareto front.In experimental validation,the parts printed using the optimized parameters exhibited excellent dimensional accuracy and printing efficiency.This study comprehensively considered optimizing the printing time and size to meet quality requirements while achieving higher printing efficiency and aiding in the realization of sustainable manufacturing in the field of AM.In addition,the printing of a specific prosthetic component was used as a case study,highlighting the high demands on both dimensional precision and printing efficiency.The optimized process parameters required significantly less printing time,while satisfying the dimensional accuracy requirements.This study provides valuable insights for achieving sustainable AM using FDM. 展开更多
关键词 Fused deposition modeling Dimensional accuracy Process parameters Printing efficiency Balanced optimization Sustainable manufacturing
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Modeling of Precipitation over Africa:Progress,Challenges,and Prospects
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作者 A.A.AKINSANOLA C.N.WENHAJI +21 位作者 R.BARIMALALA P.-A.MONERIE R.D.DIXON A.T.TAMOFFO M.O.ADENIYI V.ONGOMA I.DIALLO M.GUDOSHAVA C.M.WAINWRIGHT R.JAMES K.C.SILVERIO A.FAYE S.S.NANGOMBE M.W.POKAM D.A.VONDOU N.C.G.HART I.PINTO M.KILAVI S.HAGOS E.N.RAJAGOPAL R.K.KOLLI S.JOSEPH 《Advances in Atmospheric Sciences》 2026年第1期59-86,共28页
In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and cha... In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain. 展开更多
关键词 RAINFALL MONSOON climate modeling CORDEX CMIP6 convection-permitting models
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Face-Pedestrian Joint Feature Modeling with Cross-Category Dynamic Matching for Occlusion-Robust Multi-Object Tracking
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作者 Qin Hu Hongshan Kong 《Computers, Materials & Continua》 2026年第1期870-900,共31页
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba... To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions. 展开更多
关键词 Cross-category dynamic binding joint feature modeling face-pedestrian association multi object tracking occlusion robustness
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FDM成型PLA件有限元模拟及成型工艺分析
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作者 郭玉波 崔琦 《塑料》 北大核心 2025年第5期146-152,158,共8页
以熔融沉积成型(FDM)聚乳酸(PLA)制件为研究对象,建立PLA制件有限元模型,并结合“生死单元技术”进行温度场模拟,采用正交试验研究打印工艺参数对FDM成型制件成型质量的影响,确定了最优的打印工艺参数。研究结果表明,采用ANSYS有限元模... 以熔融沉积成型(FDM)聚乳酸(PLA)制件为研究对象,建立PLA制件有限元模型,并结合“生死单元技术”进行温度场模拟,采用正交试验研究打印工艺参数对FDM成型制件成型质量的影响,确定了最优的打印工艺参数。研究结果表明,采用ANSYS有限元模拟得到了PLA件在FDM成型过程中的温度场分布特征,为正交试验的研究提供分析依据;按照4水平4要素(L16)正交试验,研究了分层厚度、打印速度、喷嘴温度、热床温度对制件成型质量的影响。采用综合平衡法得到了最优工艺参数为分层厚度为0.25 mm、打印速度为45 mm/s、喷嘴温度为190℃、热床温度为70℃。最后,通过误差分析证明了实验结果的合理性。 展开更多
关键词 fdm成型 ANSYS有限元模拟 正交试验 聚乳酸(PLA) 工艺参数
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FDM型3D打印产品强度提高分析研究
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作者 王继群 《北京工业职业技术学院学报》 2025年第4期1-4,共4页
FDM型3D打印技术广泛应用于多个生产领域,但其打印制造的产品强度,与传统的机加工产品相比,仍然有一定的差距。为了提高FDM型3D打印产品的强度,通过介绍打印的技术原理,分析影响打印产品强度的各种因素,探讨了提高打印产品强度的具体优... FDM型3D打印技术广泛应用于多个生产领域,但其打印制造的产品强度,与传统的机加工产品相比,仍然有一定的差距。为了提高FDM型3D打印产品的强度,通过介绍打印的技术原理,分析影响打印产品强度的各种因素,探讨了提高打印产品强度的具体优化措施。样件的强度测试结果证明,采用打印参数优化与材料结构优化相结合、改进打印方向的方式,强度提升效果最好。 展开更多
关键词 fdm型3D打印 产品强度 打印参数 结构优化
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FDM型3D打印技术参数优化研究
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作者 王继群 《科技视界》 2025年第7期14-17,共4页
3D打印技术被广泛应用于各个领域,3D打印各种参数的设置会对产品的质量产生较大的影响,本文对熔融沉积成型(FDM)技术的3D打印技术参数进行了分析研究,采用迭代调整的算法对打印技术参数进行优化,给出了参数优化的步骤,经过实际试验测试... 3D打印技术被广泛应用于各个领域,3D打印各种参数的设置会对产品的质量产生较大的影响,本文对熔融沉积成型(FDM)技术的3D打印技术参数进行了分析研究,采用迭代调整的算法对打印技术参数进行优化,给出了参数优化的步骤,经过实际试验测试,最终获得了优化后的3D打印参数,提高了打印效果。 展开更多
关键词 3D打印技术 熔融沉积成型(fdm) 参数优化
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基于FDM技术的蕾丝3D打印面料开发 被引量:1
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作者 程燕婷 孟家光 +1 位作者 薛涛 刘晓巧 《针织工业》 北大核心 2025年第2期1-4,共4页
为了丰富3D打印面料的花型,增加目前市面上蕾丝面料的外观、风格及品种,通过正交试验分析,得到蕾丝3D打印面料的最佳打印参数为:分层厚度0.20 mm,打印速度90 mm/s,打印温度220℃。以柔性PLA为材料,采用FDM技术,在最佳打印参数下,对3ds ... 为了丰富3D打印面料的花型,增加目前市面上蕾丝面料的外观、风格及品种,通过正交试验分析,得到蕾丝3D打印面料的最佳打印参数为:分层厚度0.20 mm,打印速度90 mm/s,打印温度220℃。以柔性PLA为材料,采用FDM技术,在最佳打印参数下,对3ds Max软件中模拟的模型进行打印,开发出一款具有科技感和时尚感的蕾丝3D打印面料。对蕾丝3D打印面料的性能进行测试,得到蕾丝3D打印面料的横向拉伸强力为74 N,纵向拉伸强力为158 N;顶破强力为204 N;横向抗弯长度为30 mm,纵向抗弯长度为32 mm;透气率为3143 L/(m^(2)·s);透湿量为8251 g/[m^(2)·(24 h)]。该研究为3D打印面料的成形精度提升及蕾丝面料的花型开发提供了参考。 展开更多
关键词 蕾丝 3D打印 fdm技术 面料开发
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Delta结构FDM 3D打印机成型精度控制方法 被引量:1
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作者 黄振兴 剡昌锋 +1 位作者 杨思维 梁玥卓 《制造业自动化》 2025年第6期75-84,共10页
随着FDM 3D打印技术的快速发展,各行业对打印效率和成型精度的要求日益提高。针对Delta结构FDM 3D打印机成型精度不足的问题,提出了一种基于BP神经网络与PID控制算法相结合的运动系统控制策略。通过将BP神经网络引入打印装置的运动控制... 随着FDM 3D打印技术的快速发展,各行业对打印效率和成型精度的要求日益提高。针对Delta结构FDM 3D打印机成型精度不足的问题,提出了一种基于BP神经网络与PID控制算法相结合的运动系统控制策略。通过将BP神经网络引入打印装置的运动控制系统,实现了控制参数的动态自适应调整,从而有效提升了打印过程的稳定性和精确性。实验结果表明,该控制策略显著降低了打印误差,改善了成型件的表面质量和尺寸精度。本研究为Delta结构FDM 3D打印机的精度提升提供了新的解决方案,对推动3D打印技术的发展具有重要的理论意义和实际应用价值。 展开更多
关键词 Delta结构 fdm 3D打印机 成型精度 控制方法
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MODELING RADIO RESOURCE MANAGEMENT IN COGNITIVE RADIO SYSTEM BASED ON OFDMA USING COLORED PETRI NET 被引量:2
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作者 Lu Yanhui Zhang Yuqiong Yang Shouyi Mu Xiaomin 《Journal of Electronics(China)》 2010年第5期671-676,共6页
Cognitive Radio(CR) system based on Orthogonal Frequency Division Multiple Access(OFDMA),such as Wireless Regional Area Networks(WRAN) and Worldwide Interoperability for Microwave Access(WiMAX),often attempt to improv... Cognitive Radio(CR) system based on Orthogonal Frequency Division Multiple Access(OFDMA),such as Wireless Regional Area Networks(WRAN) and Worldwide Interoperability for Microwave Access(WiMAX),often attempt to improve performance via dynamic radio resource management,which is characterized as concurrent processing of different traffic and nondeterministic system capacity.It is essential to design and evaluate such complex system using proper modeling and analysis tools.In the previous work,most of the communication systems were modeled as Markov Chain(MC) and Stochastic Petri Nets(SPN),which have the explicit limitation in evaluating adaptive OFDMA CR system with wide area traffic.In this paper,we develop an executable top-down hier-archical Colored Petri Net(CPN) model for adaptive OFDMA CR system,and analyze its performance using CPN tools.The results demonstrate that the CPN can model different radio resource manage-ment algorithms in CR Systems,and the CPN tools require less computational effort than Markov model using Matlab,with its flexibility and adaptability to the traffics which arrival interval and processing time are not exponentially distributed. 展开更多
关键词 Cognitive Radio (CR) Dynamic Radio Resource Management (RRM) Colored Petri Net (CPN) modeling and evaluation
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基于FSWT-FDM的露天矿爆破振动信号分解方法 被引量:1
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作者 孙冰 宋良灵 +2 位作者 曾晟 尹裕 罗志业 《金属矿山》 北大核心 2025年第7期106-113,共8页
针对高采样率下的爆破振动信号在采用傅里叶分解方法(Fourier Decomposition Method,FDM)处理时出现过度分解的问题,利用频率切片小波变换(Frequency Slice Wavelet Transform,FSWT)能提取任意频域信号的特点,提出了FSWT与FDM耦合的爆... 针对高采样率下的爆破振动信号在采用傅里叶分解方法(Fourier Decomposition Method,FDM)处理时出现过度分解的问题,利用频率切片小波变换(Frequency Slice Wavelet Transform,FSWT)能提取任意频域信号的特点,提出了FSWT与FDM耦合的爆破振动信号FSWT-FDM分解方法。采用正余弦函数模拟爆破振动信号,验证FSWT-FDM方法对信号的分解效果,并与FDM方法进行了对比。结果表明:与直接对信号进行FDM分解相比,采用FSWT-FDM方法的无效信号分量大幅减少,程序运行效率增加;使用FSWT提取的优势频带信号可以进一步进行傅里叶分解,且产生的信号分量与直接进行傅里叶分解的有效信号分量一致;以信号分量的相关系数和能量占比筛选出重构分量,重构信号的总能量、峰值振动速度、最大误差等指标证明FSWT-FDM方法有效保留了原始信号特征信息。通过对实测露天矿爆破振动信号的分析,验证了FSWT-FDM方法在保留原始信号时频特征的同时,减少了信号分解时的无效信号分量,为露天矿爆破振动信号分解提供了新思路。 展开更多
关键词 露天爆破 爆破振动信号 fdm FSWT 优势频带信号
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基于FDM的多自由度3D打印技术研究 被引量:1
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作者 邢洪亚 陈继飞 《南方农机》 2025年第1期138-141,共4页
【目的】在学术研究与工业实践中,FDM型3D打印技术凭借其特有的分层叠加构造方法,极大地突破了传统零部件制造工艺中存在的约束和局限。然而,这种逐层构建的机制也带来了若干挑战,如阶梯效应显著以及需额外添加支撑结构等。【方法】为... 【目的】在学术研究与工业实践中,FDM型3D打印技术凭借其特有的分层叠加构造方法,极大地突破了传统零部件制造工艺中存在的约束和局限。然而,这种逐层构建的机制也带来了若干挑战,如阶梯效应显著以及需额外添加支撑结构等。【方法】为了克服传统层式打印技术所固有的局限性,研究人员提出了多自由度3D打印技术。文章对多自由度3D打印技术进行了系统性回顾,剖析了传统FDM型3D打印机所面临的一系列挑战与局限,介绍了增加打印机自由度的三种方法:(1)在原有的三个平动自由度的基础上,增加旋转自由度;(2)使用机械臂等串联机构;(3)使用delta型和stewart型等并联机构。【结果】基于FDM的多自由度3D打印技术是一个多学科融合的技术,硬件机械结构与软件控制系统是其两大支柱,因而该技术的未来发展需双管齐下,即在硬件与软件领域不断追求创新。【结论】具备高度灵活性的多自由度机器人在诸如多材料加工、原位制造、混合制造及闭环控制等方面也具有较高的研究价值。 展开更多
关键词 fdm 3D打印 多自由度 并联机构
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基于FDM的GF/PLA复合材料3D打印工艺研究 被引量:1
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作者 张永超 何科 +5 位作者 陈荣 王晓 李攀 周勇 王浩然 毕晓妹 《化学推进剂与高分子材料》 2025年第4期41-45,共5页
采用基于熔融沉积成型(FDM)的3D打印工艺,以玻璃纤维增强聚乳酸(GF/PLA)复合材料为打印原材料,分别通过桌面级丝材打印机和工业级粒料打印机打印测试样件(打印件),研究填充角度、打印速度、打印环境气氛及打印设备对打印件拉伸性能的影... 采用基于熔融沉积成型(FDM)的3D打印工艺,以玻璃纤维增强聚乳酸(GF/PLA)复合材料为打印原材料,分别通过桌面级丝材打印机和工业级粒料打印机打印测试样件(打印件),研究填充角度、打印速度、打印环境气氛及打印设备对打印件拉伸性能的影响。结果表明:填充方式对打印件的拉伸性能影响较为明显,0°方向填充的打印件拉伸强度和断裂伸长率均最大,0°/90°方向填充的次之,90°方向填充的最小;打印件的拉伸强度随打印速度的增大而降低,而断裂伸长率随打印速度的增大而增大,当打印速度从15 mm/s提高到60 mm/s时,拉伸强度降低了16.46%,断裂伸长率提高了68.70%;将打印成型仓进行隔绝氧气处理,可提高打印件的拉伸性能,在氩气氛围下打印的样件断裂伸长率显著提高;与丝材打印机制备的样件相比,粒料打印机制备的样件力学性能较佳,拉伸强度和断裂伸长率分别提高了3.78%和16.83%。 展开更多
关键词 熔融沉积成型(fdm) 玻璃纤维增强聚乳酸复合材料 拉伸强度 断裂伸长率
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基于改进GA-BP神经网络的FDM式3D打印机故障诊断
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作者 殷冬年 解乃军 纪有旺 《印刷与数字媒体技术研究》 北大核心 2025年第4期169-181,共13页
针对当前FDM(Fused Deposition Modeling)式3D打印机故障诊断方式存在精确度低、灵活性不足等缺陷,本研究提出了一种基于改进GA-BP神经网络的FDM式3D打印机故障诊断模型。通过分析影响打印故障的因素,得出故障诊断模型的输入变量,以此构... 针对当前FDM(Fused Deposition Modeling)式3D打印机故障诊断方式存在精确度低、灵活性不足等缺陷,本研究提出了一种基于改进GA-BP神经网络的FDM式3D打印机故障诊断模型。通过分析影响打印故障的因素,得出故障诊断模型的输入变量,以此构建BP神经网络模型;针对BP学习算法易陷入局部最优解问题,利用遗传算法优化网络的初始权值和阈值,并进一步结合遗传进化原理,改进了遗传算法自适应交叉和变异概率策略。通过实验结果分析,本研究所提的基于改进GA-BP神经网络的3D打印机故障诊断模型的诊断准确率在97%以上,比基于BP神经网络的基础诊断模型的诊断准确率提升了12.9%,迭代次数减少了22次,比传统阈值检测法的诊断准确率提升了24.3%。 展开更多
关键词 fdm式3D打印机 故障诊断 BP神经网络 遗传算法 自适应交叉和变异概率
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A Multi-Level Semantic Constraint Approach for Highway Tunnel Scene Twin Modeling 被引量:1
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作者 LI Yufei XIE Yakun +3 位作者 CHEN Mingzhen ZHAO Yaoji TU Jiaxing HU Ya 《Journal of Geodesy and Geoinformation Science》 2025年第2期37-56,共20页
As a key node of modern transportation network,the informationization management of road tunnels is crucial to ensure the operation safety and traffic efficiency.However,the existing tunnel vehicle modeling methods ge... As a key node of modern transportation network,the informationization management of road tunnels is crucial to ensure the operation safety and traffic efficiency.However,the existing tunnel vehicle modeling methods generally have problems such as insufficient 3D scene description capability and low dynamic update efficiency,which are difficult to meet the demand of real-time accurate management.For this reason,this paper proposes a vehicle twin modeling method for road tunnels.This approach starts from the actual management needs,and supports multi-level dynamic modeling from vehicle type,size to color by constructing a vehicle model library that can be flexibly invoked;at the same time,semantic constraint rules with geometric layout,behavioral attributes,and spatial relationships are designed to ensure that the virtual model matches with the real model with a high degree of similarity;ultimately,the prototype system is constructed and the case region is selected for the case study,and the dynamic vehicle status in the tunnel is realized by integrating real-time monitoring data with semantic constraints for precise virtual-real mapping.Finally,the prototype system is constructed and case experiments are conducted in selected case areas,which are combined with real-time monitoring data to realize dynamic updating and three-dimensional visualization of vehicle states in tunnels.The experiments show that the proposed method can run smoothly with an average rendering efficiency of 17.70 ms while guaranteeing the modeling accuracy(composite similarity of 0.867),which significantly improves the real-time and intuitive tunnel management.The research results provide reliable technical support for intelligent operation and emergency response of road tunnels,and offer new ideas for digital twin modeling of complex scenes. 展开更多
关键词 highway tunnel twin modeling multi-level semantic constraints tunnel vehicles multidimensional modeling
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Solubility and Thermodynamic Modeling of 3⁃Nitro⁃1,2,4⁃triazole⁃5⁃one(NTO)in Different Binary Solvents 被引量:1
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作者 GUO Hao-qi YANG Yu-lin 《含能材料》 北大核心 2025年第3期295-303,共9页
Using a dynamic laser monitoring technique,the solubility of 3-nitro-1,2,4-triazole-5-one(NTO)was investigated in two different binary systems,namely hydroxylamine nitrate(HAN)-water and boric acid(HB)-water ranging f... Using a dynamic laser monitoring technique,the solubility of 3-nitro-1,2,4-triazole-5-one(NTO)was investigated in two different binary systems,namely hydroxylamine nitrate(HAN)-water and boric acid(HB)-water ranging from 278.15 K to 318.15 K.The solubility in each system was found to be positively correlated with temperature.Furthermore,solubility data were analyzed using four equations:the modified Apelblat equation,Van’t Hoff equation,λh equation and CNIBS/R-K equations,and they provided satisfactory results for both two systems.The average root-mean-square deviation(105RMSD)values for these models were less than 13.93.Calculations utilizing the Van’t Hoff equation and Gibbs equations facilitated the derivation of apparent thermodynamic properties of NTO dissolution in the two systems,including values for Gibbs free energy,enthalpy and entropy.The%ζ_(H)is larger than%ζ_(TS),and all the%ζ_(H)data are≥58.63%,indicating that the enthalpy make a greater contribution than entropy to theΔG_(soln)^(Θ). 展开更多
关键词 3-nitro-l 2 4-triazole-5-one(NTO) SOLUBILITY thermodynamic models apparent thermodynamic analysis
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Candida albicans and colorectal cancer:A paradoxical role revealed through metabolite profiling and prognostic modeling 被引量:2
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作者 Hao-Ling Zhang Rui Zhao +8 位作者 Di Wang Siti Nurfatimah Mohd Sapudin Badrul Hisham Yahaya Mohammad Syamsul Reza Harun Zhong-Wen Zhang Zhi-Jing Song Yan-Ting Liu Sandai Doblin Ping Lu 《World Journal of Clinical Oncology》 2025年第4期195-279,共85页
BACKGROUND Emerging evidence implicates Candida albicans(C.albicans)in human oncogenesis.Notably,studies have supported its involvement in regulating outcomes in colorectal cancer(CRC).This study investigated the para... BACKGROUND Emerging evidence implicates Candida albicans(C.albicans)in human oncogenesis.Notably,studies have supported its involvement in regulating outcomes in colorectal cancer(CRC).This study investigated the paradoxical role of C.albicans in CRC,aiming to determine whether it promotes or suppresses tumor development,with a focus on the mechanistic basis linked to its metabolic profile.AIM To investigate the dual role of C.albicans in the development and progression of CRC through metabolite profiling and to establish a prognostic model that integrates the microbial and metabolic interactions in CRC,providing insights into potential therapeutic strategies and clinical outcomes.METHODSA prognostic model integrating C. albicans with CRC was developed, incorporating enrichment analysis, immuneinfiltration profiling, survival analysis, Mendelian randomization, single-cell sequencing, and spatial transcriptomics.The effects of the C. albicans metabolite mixture on CRC cells were subsequently validated in vitro. Theprimary metabolite composition was characterized using liquid chromatography-mass spectrometry.RESULTSA prognostic model based on five specific mRNA markers, EHD4, LIME1, GADD45B, TIMP1, and FDFT1, wasestablished. The C. albicans metabolite mixture significantly reduced CRC cell viability. Post-treatment analysisrevealed a significant decrease in gene expression in HT29 cells, while the expression levels of TIMP1, EHD4, andGADD45B were significantly elevated in HCT116 cells. Conversely, LIME1 expression and that of other CRC celllines showed reductions. In normal colonic epithelial cells (NCM460), GADD45B, TIMP1, and FDFT1 expressionlevels were significantly increased, while LIME1 and EHD4 levels were markedly reduced. Following metabolitetreatment, the invasive and migratory capabilities of NCM460, HT29, and HCT116 cells were reduced. Quantitativeanalysis of extracellular ATP post-treatment showed a significant elevation (P < 0.01). The C. albicans metabolitemixture had no effect on reactive oxygen species accumulation in CRC cells but led to a reduction in mitochondrialmembrane potential, increased intracellular lipid peroxidation, and induced apoptosis. Metabolomic profilingrevealed significant alterations, with 516 metabolites upregulated and 531 downregulated.CONCLUSIONThis study introduced a novel prognostic model for CRC risk assessment. The findings suggested that the C.albicans metabolite mixture exerted an inhibitory effect on CRC initiation. 展开更多
关键词 Candida albicans Colorectal cancer Metabolic characteristics Extracellular ATP Prognostic model
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影响FDM打印精度的因素研究
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作者 武钰 杜嘉伟 《机械工程与自动化》 2025年第5期24-26,共3页
随着桌面式熔融沉积成型(FDM)技术的快速发展,测试件的精度和表面质量成为影响FDM三维(3D)打印机发展的关键因素。针对FDM 3D打印机的工作流程,深入探究了多个因素对打印产品质量的影响,并展开了相应的实验分析。这些因素涵盖打印速度... 随着桌面式熔融沉积成型(FDM)技术的快速发展,测试件的精度和表面质量成为影响FDM三维(3D)打印机发展的关键因素。针对FDM 3D打印机的工作流程,深入探究了多个因素对打印产品质量的影响,并展开了相应的实验分析。这些因素涵盖打印速度的快慢、填充率的高低、层片厚度的大小、打印机本身的性能优劣、模型的精准程度,以及打印件摆放角度的差异等方面,旨在全面且精准地揭示各因素与打印产品质量之间的内在关联和作用机制。提出了改善打印件成型精度和表面质量的方法,为后续提高FDM 3D打印质量提供了参考。 展开更多
关键词 fdm 3D打印 表面质量 精度
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基于并行FDM模型和流网计算的土体渗流安全系数分析
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作者 杨智 《城市道桥与防洪》 2025年第3期275-279,共5页
常规二维稳态流网计算得到的渗流安全系数接近于临界值,将导致设计过程中采取超量设计的方法对结构进行冗余防护。因此,提出了基于有限差分法(FDM)模型对流网进行二次修正的方法,将计算截面离散化,利用FDM步长单元小、迭代计算次数多的... 常规二维稳态流网计算得到的渗流安全系数接近于临界值,将导致设计过程中采取超量设计的方法对结构进行冗余防护。因此,提出了基于有限差分法(FDM)模型对流网进行二次修正的方法,将计算截面离散化,利用FDM步长单元小、迭代计算次数多的优势获得新的等势线和流线,并用修正后的水头梯度和渗流路径重新计算渗流量和安全系数。结果表明:基于FDM模型修正的每日渗流量为2.77 m^(3)/m,与二维稳态流网的计算值3.29 m^(3)/m基本一致,但经FDM模型修正后的渗流安全系数为2.7,远大于二维稳态流网的计算值1.6。由此说明,经FDM模型修正后的流网计算结果精度较高,结构安全性更可靠。 展开更多
关键词 流网 有限差分法 fdm模型 渗流安全系数
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Influence of different data selection criteria on internal geomagnetic field modeling 被引量:4
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作者 HongBo Yao JuYuan Xu +3 位作者 Yi Jiang Qing Yan Liang Yin PengFei Liu 《Earth and Planetary Physics》 2025年第3期541-549,共9页
Earth’s internal core and crustal magnetic fields,as measured by geomagnetic satellites like MSS-1(Macao Science Satellite-1)and Swarm,are vital for understanding core dynamics and tectonic evolution.To model these i... Earth’s internal core and crustal magnetic fields,as measured by geomagnetic satellites like MSS-1(Macao Science Satellite-1)and Swarm,are vital for understanding core dynamics and tectonic evolution.To model these internal magnetic fields accurately,data selection based on specific criteria is often employed to minimize the influence of rapidly changing current systems in the ionosphere and magnetosphere.However,the quantitative impact of various data selection criteria on internal geomagnetic field modeling is not well understood.This study aims to address this issue and provide a reference for constructing and applying geomagnetic field models.First,we collect the latest MSS-1 and Swarm satellite magnetic data and summarize widely used data selection criteria in geomagnetic field modeling.Second,we briefly describe the method to co-estimate the core,crustal,and large-scale magnetospheric fields using satellite magnetic data.Finally,we conduct a series of field modeling experiments with different data selection criteria to quantitatively estimate their influence.Our numerical experiments confirm that without selecting data from dark regions and geomagnetically quiet times,the resulting internal field differences at the Earth’s surface can range from tens to hundreds of nanotesla(nT).Additionally,we find that the uncertainties introduced into field models by different data selection criteria are significantly larger than the measurement accuracy of modern geomagnetic satellites.These uncertainties should be considered when utilizing constructed magnetic field models for scientific research and applications. 展开更多
关键词 Macao Science Satellite-1 SWARM geomagnetic field modeling data selection core field crustal field
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Mechanical response analysis of asphalt pavement considering top-down crack based on FDM-DEM coupling simulation 被引量:2
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作者 Min Wang Xin Yu Chen Chen 《Journal of Road Engineering》 2025年第1期92-105,共14页
The occurrence of top-down(TD)cracking has gradually become a prevalent issue in semi-rigid base asphalt pavements after prolonged service.A coupled simulation model integrating the finite difference method(FDM)and di... The occurrence of top-down(TD)cracking has gradually become a prevalent issue in semi-rigid base asphalt pavements after prolonged service.A coupled simulation model integrating the finite difference method(FDM)and discrete element method(DEM)was employed to investigate the mechanical behavior of asphalt pavement containing a pre-existing TD crack.The mesoscopic parameters of the model were calibrated based on the mixture modulus and the static mechanical response on the MLS66 test road.Finally,an analysis was performed to assess how variations in TD crack depth and longitudinal length affect the distribution patterns of transverse tensile stress,vertical shear stress,and vertical compressive stress.The results indicate that the vertical propagation of TD crack significantly increases both the tensile stress value and range on the middle surface,while the longitudinal development of TD crack has minimal impact.This phenomenon may result in more severe fatigue failure on the middle surface.With the vertical and longitudinal development of TD crack,the vertical shear stress and compressive stress show obvious"two-stage"characteristics.When the crack's vertical length reaches 40 mm,there is a sharp increase in stress on the upper surface.As the crack continues to propagate vertically,the growth of stress on the upper surface becomes negligible,while the stress in the middle and lower layers increased significantly.Conversely,for longitudinal development of TD crack,any changes in stress are insignificant when their length is less than 180 mm;however,as they continue to develop longitudinally beyond this threshold,there is a sharp increase in stress levels.These findings hold great significance for understanding pavement structure deterioration and maintenance behavior associated with TD crack. 展开更多
关键词 Full-scale pavement structure Top-down crack fdm-DEM coupling model Mechanical response
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