Objective To explore the role of curcumin(Cur)in improving IgA nephropathy(IgAN)and its related mechanisms.Methods Fifty 7-month-old miR-23b knockout(miR-23b^(-/-))mice weighing(25±5)g were used to establish an I...Objective To explore the role of curcumin(Cur)in improving IgA nephropathy(IgAN)and its related mechanisms.Methods Fifty 7-month-old miR-23b knockout(miR-23b^(-/-))mice weighing(25±5)g were used to establish an IgAN disease model,and were randomly divided into IgAN group,IgAN+Cur(150 mg/kg)group and IgAN+Cur(300 mg/kg)group using simple randomisation.展开更多
Urban ecological resilience(UER)is a fundamental requirement for sustainable urban development.Ecosystem services(ESs)support urban resilience in many ways;however,it remains unknown how the various ES types affect UE...Urban ecological resilience(UER)is a fundamental requirement for sustainable urban development.Ecosystem services(ESs)support urban resilience in many ways;however,it remains unknown how the various ES types affect UER.In this study,10 ESs were selected to characterize the 4 types of ES in the Pearl River Delta urban agglomeration(PRD),and the InVEST model,CASA model,and nuclear density analysis were used to evaluate the various ESs.We used a morphological resilience-density resilienceeconomic resilience framework to assess UER,and the structure equation model was used to explore the effects of ESs on UER.展开更多
A novel wrist-inspired soft actuator,which is driven by a magneto-pneumatic hybrid system and based on a Kresling origami unit,is proposed.The geometric model,kinematic analysis model,and quasistatic analysis model of...A novel wrist-inspired soft actuator,which is driven by a magneto-pneumatic hybrid system and based on a Kresling origami unit,is proposed.The geometric model,kinematic analysis model,and quasistatic analysis model of the Kresling origami unit are presented.A key focus is on the formulation and investigation of the variation in rotation angle using the kinematic analysis model.A wrist-inspired soft actuator is designed,and its quasistatic characteristics are validated through various experiments.The paper proposes an innovative magneto-pneumatic hybrid actuation method,capable of achieving bidirectional torsion.This actuation method is experimentally validated,demonstrating the actuator's ability to maintain 3 steady states and its capability for bidirectional torsion deformation.Furthermore,the paper highlights the potential of the Kresling origami unit in designing soft actuators capable of achieving large rotation angles.For instance,an actuator with 6 sides(n=6)is shown to achieve a rotation angle of 239.5°,and its rotation ratio exceeds 277°,about twice the largest one reported in other literature.The actuator offers a practical and effective solution for bidirectional torsion deformation in soft robotic applications.展开更多
文摘Objective To explore the role of curcumin(Cur)in improving IgA nephropathy(IgAN)and its related mechanisms.Methods Fifty 7-month-old miR-23b knockout(miR-23b^(-/-))mice weighing(25±5)g were used to establish an IgAN disease model,and were randomly divided into IgAN group,IgAN+Cur(150 mg/kg)group and IgAN+Cur(300 mg/kg)group using simple randomisation.
基金supported by Chaohu University for the Start-UP grant(grant number KYQD-2023068)the National Natural Science Foundation of China(grant number42376226)
文摘Urban ecological resilience(UER)is a fundamental requirement for sustainable urban development.Ecosystem services(ESs)support urban resilience in many ways;however,it remains unknown how the various ES types affect UER.In this study,10 ESs were selected to characterize the 4 types of ES in the Pearl River Delta urban agglomeration(PRD),and the InVEST model,CASA model,and nuclear density analysis were used to evaluate the various ESs.We used a morphological resilience-density resilienceeconomic resilience framework to assess UER,and the structure equation model was used to explore the effects of ESs on UER.
基金supported by the National Natural Science Foundation of China(Grant Nos.91748209 and 11402229)the specialized research projects of Huanjiang Laboratory.
文摘A novel wrist-inspired soft actuator,which is driven by a magneto-pneumatic hybrid system and based on a Kresling origami unit,is proposed.The geometric model,kinematic analysis model,and quasistatic analysis model of the Kresling origami unit are presented.A key focus is on the formulation and investigation of the variation in rotation angle using the kinematic analysis model.A wrist-inspired soft actuator is designed,and its quasistatic characteristics are validated through various experiments.The paper proposes an innovative magneto-pneumatic hybrid actuation method,capable of achieving bidirectional torsion.This actuation method is experimentally validated,demonstrating the actuator's ability to maintain 3 steady states and its capability for bidirectional torsion deformation.Furthermore,the paper highlights the potential of the Kresling origami unit in designing soft actuators capable of achieving large rotation angles.For instance,an actuator with 6 sides(n=6)is shown to achieve a rotation angle of 239.5°,and its rotation ratio exceeds 277°,about twice the largest one reported in other literature.The actuator offers a practical and effective solution for bidirectional torsion deformation in soft robotic applications.
