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PM_(10) dust emission in the Erenhot-Huailai zone of northern China based on model simulation
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作者 WANG Yong YAN Ping +3 位作者 WU Wei WANG Yijiao HU Chanjuan LI Shuangquan 《Journal of Arid Land》 2025年第3期324-336,共13页
The Erenhot-Huailai zone, as an important dust emission source area in northern China, affects the air quality of Beijing City, Tianjin City, and Hebei Province and human activities in this zone have a profound impact... The Erenhot-Huailai zone, as an important dust emission source area in northern China, affects the air quality of Beijing City, Tianjin City, and Hebei Province and human activities in this zone have a profound impact on surface dust emission. In order to explore the main source areas of surface dust emission and quantify the impacts of human activities on surface dust emission, we investigated the surface dust emission of different land types on the Erenhot-Huailai zone by model simulation, field observation, and comparative analysis. The results showed that the average annual inhalable atmospheric particles(PM_(10)) dust emission fluxes in arid grassland, Hunshandake Sandy Land, semi-arid grassland,semi-arid agro-pastoral area, dry sub-humid agro-pastoral area, and semi-humid agro-pastoral area were 4.41, 0.71, 3.64, 1.94, 0.24, and 0.14 t/hm^(2), respectively, and dust emission in these lands occurred mainly from April to May. Due to the influence of human activities on surface dust emission, dust emission fluxes from different land types were 1.66–4.41 times greater than those of their background areas, and dust emission fluxes from the main dust source areas were 1.66–3.89 times greater than those of their background areas. According to calculation, the amount of PM_(10) dust emission influenced by human disturbance accounted for up to 58.00% of the total dust emission in the study area. In addition, the comparative analysis of model simulation and field observation results showed that the simulated and observed dust emission fluxes were relatively close to each other, with differences ranging from 0.01 to 0.21 t/hm^(2) in different months, which indicated that the community land model version 4.5(CLM4.5) had a high accuracy. In conclusion, model simulation results have important reference significance for identifying dust source areas and quantifying the contribution of human activities to surface dust emission. 展开更多
关键词 northern China classification of land type model simulation dust emission human disturbance
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Understanding long-term memory in global mean temperature:An attribution study based on model simulations 被引量:1
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作者 QIU Min YUAN Naiming YUAN Shujie 《Atmospheric and Oceanic Science Letters》 CSCD 2020年第5期485-492,共8页
Long-term memory(LTM)in the climate system has been well recognized and applied in different research fields,but the origins of this property are still not clear.In this work,the authors contribute to this issue by st... Long-term memory(LTM)in the climate system has been well recognized and applied in different research fields,but the origins of this property are still not clear.In this work,the authors contribute to this issue by studying model simulations under different scenarios.The global mean temperatures from pre-industrial control runs(pi Control),historical(all forcings)simulations,natural forcing only simulations(Historical Nat),greenhouse gas forcing only simulations(Historical GHG),etc.,are analyzed using the detrended fluctuation analysis.The authors find that the LTM already exists in the pi Control simulations,indicating the important roles of internal natural variability in producing the LTM.By comparing the results among different scenarios,the LTM from the piControl runs is further found to be strengthened by adding natural forcings such as the volcanic forcing and the solar forcing.Accordingly,the observed LTM in the climate system is suggested to be mainly controlled by both the‘internal’natural variability and the‘external’natural forcings.The anthropogenic forcings,however,may weaken the LTM.In the projections from RCP2.6 to RCP8.5,a weakening trend of the LTM strength is found.In view of the close relations between the climate memory and the climate predictability,a reduced predictability may be expected in a warming climate. 展开更多
关键词 Long-term memory model simulations ATTRIBUTION detrended fluctuation analysis
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Facilitated Prediction of Micropollutant Degradation via UV-AOPs in Various Waters by Combining Model Simulation and Portable Measurement
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作者 Yanyan Huang Mengkai Li +3 位作者 Zhe Sun Wentao Li James R.Bolton Zhimin Qiang 《Engineering》 SCIE EI CAS CSCD 2024年第6期87-95,共9页
The degradation of micropollutants in water via ultraviolet(UV)-based advanced oxidation processes(AOPs)is strongly dependent on the water matrix.Various reactive radicals(RRs)formed in UV-AOPs have different reaction... The degradation of micropollutants in water via ultraviolet(UV)-based advanced oxidation processes(AOPs)is strongly dependent on the water matrix.Various reactive radicals(RRs)formed in UV-AOPs have different reaction selectivities toward water matrices and degradation efficiencies for target micropollutants.Hence,process selection and optimization are crucial.This study developed a facilitated prediction method for the photon fluence-based rate constant for micropollutant degradation(K′_(p,MP))in various UV-AOPs by combining model simulation with portable measurement.Portable methods for measuring the scavenging capacities of the principal RRs(RRSCs)involved in UV-AOPs(i.e.,HO^(·),SO_(4)^(·-),and Cl^(·))using a mini-fluidic photoreaction system were proposed.The simulation models consisted of photochemical,quantitative structure–activity relationship,and radical concentration steady-state approximation models.The RRSCs were determined in eight test waters,and a higher RRSC was found to be associated with a more complex water matrix.Then,by taking sulfamethazine,caffeine,and carbamazepine as model micropollutants,the k′_(p,MP) values in various UV-AOPs were predicted and further verified experimentally.A lower k′_(p,MP) was found to be associated with a higher RRSC for a stronger RR competition;for example,k′_(p,MP) values of 130.9 and 332.5 m^(2) einstein^(–1),respectively,were obtained for carbamazepine degradation by UV/H_(2)O_(2) in the raw water(RRSC=9.47×10^(4) s^(-1))and sand-filtered effluent(RRSC=2.87×10^(4) s^(-1))of a drinking water treatment plant.The developed method facilitates process selection and optimization for UV-AOPs,which is essential for increasing the efficiency and cost-effectiveness of water treatment. 展开更多
关键词 UV-AOPs Micropollutant degradation Reactive radicals Water matrix model simulation
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Model Simulations of Mesoscale Eddies and Deep Convection in the Labrador Sea
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作者 Jieshun ZHU Entcho DEMIROV +1 位作者 Ying ZHANG Ania POLOMSKA-HARLICK 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2014年第4期743-754,共12页
Deep convection in the Labrador Sea is confined within a small region in the southwest part of the basin.The strength of deep convection in this region is related to the local atmospheric and ocean characteristics,whi... Deep convection in the Labrador Sea is confined within a small region in the southwest part of the basin.The strength of deep convection in this region is related to the local atmospheric and ocean characteristics,which favor processes of deep convection preconditioning and intense air-sea exchange during the winter season.In this study,we explored the effect of eddy-induced flux transport on the stratification of the Labrador Sea and the properties of deep convection.Simulations from an eddy-resolving ocean model are presented for the Labrador Sea.The general circulation was well simulated by the model,including the seasonal cycle of the deep Labrador Current.The simulated distribution of the surface eddy kinetic energy was also close to that derived from Topex-Poseidon satellite altimeter data,but with smaller magnitude.The energy transfer diagnostics indicated that Irminger rings are generated by both baroclinic and barotropic processes; however,when they propagate into the interior basin,the barotropic process also disperses them by converting the eddy energy to the mean flow.In contrast to eddy-permitting simulations,deep convection in the Labrador Sea was better represented in the eddyresolving model regarding their lateral position.Further analysis indicated that the improvement might be due to the lateral eddy flux associated with the resolved Irminger rings in the eddy-resolving model,which contributes to a realistic position of the isopycnal dome in the Labrador Sea and correspondingly a realistic site of deep convection. 展开更多
关键词 mesoscale eddies deep convection labrador Sea model simulation
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Model simulations to determine optimal fishing effort and season duration for a tropical shrimp fishery
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作者 CHEN Weizhong Hussain AL-FOUDARI 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2018年第5期1860-1869,共10页
Kuwait's shrimp fishery presents typical tropical shrimp fishery characteristics with highly variable recruitment, fast growth and strong seasonal patterns. Both the General Production Model and Age-structured Mod... Kuwait's shrimp fishery presents typical tropical shrimp fishery characteristics with highly variable recruitment, fast growth and strong seasonal patterns. Both the General Production Model and Age-structured Model were chosen to assess the stock status of the Kuwait's shrimp fishery. The estimated Maximum Sustainable Yield(MSY) was 2 518 metric ton(t) with a corresponding fishing eff orts( f MSY) 7 265 standard boat-days from the General Production Model. Similar results from the Age-structured Model were 1 936 t and 6 449 boat-days respectively. Comparing these results with the average annual shrimp landings(1 772 t) and average fishing eff ort(9 710 boat-days) in the past 10 years, we concluded that the fishery was overfished. Model simulations to show the changes of recruitment, biomass and possible catch under different fishing eff ort scenarios indicated possible stock collapse if the fishing eff ort continually increase. But both shrimp recruitment and biomass will increase if the current fishing eff ort is reduced. Model simulations also showed a possible increase of MSY by delaying the opening or by closing the season earlier. Based on these results, recommendations to improve the management of Kuwait's shrimp fishery are presented. 展开更多
关键词 model simulation optimizing fishing effort optimizing fishing season shrimp fishery
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Adsorption and Step Elution of Urokinase Using Affinity Chromatography-Comparison of Data with Rate Model Simulation
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作者 Mohammad Reza Aboudzadeh Rovais 《Chinese Journal of Biomedical Engineering(English Edition)》 2004年第4期166-178,共13页
A non-equilibrium chromatographic rate model was employed to simulate the affinity chromatography of urokinase. The chromatography process was developed to a yield of high purity product of urokinase from crude materi... A non-equilibrium chromatographic rate model was employed to simulate the affinity chromatography of urokinase. The chromatography process was developed to a yield of high purity product of urokinase from crude materials. The affinity gel used in the process was prepared by an epichlorohydrin-activation method using epichlorohydrin activated Sepharose 4B as a matrix and p-aminobenzamidine as a ligand. The chromatographic process were numerically simulated and analyzed with the aid of VERSE-LC computer simulator. Considering the basic principles, rate model with the back mixing in column inlet was utilized in simulating and studying the effect of the column inlet pattern on other parameters. Comparison of the simulation results with the experimental data showed that the rate model can be used to describe the affinity chromatography of urokinase in a fixed bed column with satisfactory accuracy. 展开更多
关键词 Rate model simulation Affinity chromatography UROKINASE Back mixing
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Assessing Drought Vulnerability of Bulgarian Agriculture through Model Simulations 被引量:2
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作者 Zomitsa Popova Maria Ivanova +4 位作者 Luis Santos Pereira Vesselin Alexandrov Katerina Doneva Petra Alexandrova Milena Kercheva 《Journal of Environmental Science and Engineering(B)》 2012年第8期1017-1036,共20页
This study assesses vulnerability of agriculture to drought, using WINISAREG model and seasonal SPI2-index for eight climate regions (1951-2004). Results relative to Plovdiv show that in soils of large TAW (total a... This study assesses vulnerability of agriculture to drought, using WINISAREG model and seasonal SPI2-index for eight climate regions (1951-2004). Results relative to Plovdiv show that in soils of large TAW (total available water) net irrigation requirements NIRs range from 0 to 380 mm. In soils of small TAW, NIRs reach 440 mm in the very dry year. NIRs in Sofia/Silistra are about 100 mm smaller than in Plovdiv while in Sandanski they are 30-110 mm larger. Rainfed maize is associated with great yield variability (29% 〈 Cv 〈 72%). Considering an economical RYD (relative yield decrease) threshold, 32% of years are risky when TA Wis large in Plovdiv that is double than in Sofia and half than in Sandanski. In North Bulgaria the risky years are 10% in Pleven/Silistra that is half than in Lom. In Plovdiv region reliable relationships (R2 〉 91%) were found relating the SPI2 "July-Aug." with simulated RYD of rainfed maize while remaining relationships were less accurate (73% 〈 R2 〈 86%). Economical losses are produced when High Peak Season SPI2 〈 + 0.20 in Sandanski, SPI2 〈 - 0.50 in Plovdiv and SPI2 〈 - 0.90 in Sofia. In North Bulgaria the SPI2 threshold ranges from - 0.75 to - 1.50. Derived reliable relationships and SPl-thresholds are used for drought vulnerability mapping. 展开更多
关键词 Drought vulnerability MAIZE ISAREG simulation model SPI-index drought vulnerability mapping.
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Diagnostic of capacitively coupled radio frequency plasma from electrical discharge characteristics:comparison with optical emission spectroscopy and fluid model simulation 被引量:3
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作者 何湘 刘冲 +6 位作者 张亚春 陈建平 陈玉东 曾小军 陈秉岩 庞佳鑫 王一兵 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第2期26-33,共8页
The capacitively coupled radio frequency(CCRF)plasma has been widely used in various fields.In some cases,it requires us to estimate the range of key plasma parameters simpler and quicker in order to understand the ... The capacitively coupled radio frequency(CCRF)plasma has been widely used in various fields.In some cases,it requires us to estimate the range of key plasma parameters simpler and quicker in order to understand the behavior in plasma.In this paper,a glass vacuum chamber and a pair of plate electrodes were designed and fabricated,using 13.56 MHz radio frequency(RF)discharge technology to ionize the working gas of Ar.This discharge was mathematically described with equivalent circuit model.The discharge voltage and current of the plasma were measured atdifferent pressures and different powers.Based on the capacitively coupled homogeneous discharge model,the equivalent circuit and the analytical formula were established.The plasma density and temperature were calculated by using the equivalent impedance principle and energy balance equation.The experimental results show that when RF discharge power is 50–300 W and pressure is 25–250 Pa,the average electron temperature is about 1.7–2.1 e V and the average electron density is about 0.5?×10^17–3.6?×10^17m^-3.Agreement was found when the results were compared to those given by optical emission spectroscopy and COMSOL simulation. 展开更多
关键词 plasma diagnostic equivalent circuit model optical emission spectrometry COMSOL simulation
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Multi-agent Based Hierarchy Simulation Models of Carrier-based Aircraft Catapult Launch 被引量:19
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作者 王维军 屈香菊 郭林亮 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2008年第3期223-231,共9页
With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as ... With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as aggregation agents, the detailed components like catapult, landing gears, and disturbances are considered as meta-agents, which belong to their aggregation agent. Thus, the model with two layers is formed i.e. the aggregation agent layer and the meta-agent layer. The information communication among all agents is described. The meta-agents within one aggregation agent communicate with each other directly by information sharing, but the meta-agents, which belong to different aggregation agents exchange their information through the aggregation layer first, and then perceive it from the sharing environment, that is the aggregation agent. Thus, not only the hierarchy model is built, but also the environment perceived by each agent is specified. Meanwhile, the problem of balancing the independency of agent and the resource consumption brought by real-time communication within multi-agent system (MAS) is resolved. Each agent involved in carrier-based aircraft catapult launch is depicted, with considering the interaction within disturbed atmospheric environment and multiple motion bodies including carrier, aircraft, and landing gears. The models of reactive agents among them are derived based on tensors, and the perceived messages and inner frameworks of each agent are characterized. Finally, some results of a simulation instance are given. The simulation and modeling of dynamic system based on multi-agent system is of benefit to express physical concepts and logical hierarchy clearly and precisely. The system model can easily draw in kinds of other agents to achieve a precise simulation of more complex system. This modeling technique makes the complex integral dynamic equations of multibodies decompose into parallel operations of single agent, and it is convenient to expand, maintain, and reuse the program codes. 展开更多
关键词 multi-agent system (MAS) multi-agent based modeling (MABM) TENSOR carrier-based aircraft catapult launch hierarchy simulation model
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Quantifying the Cloud Water Resource:Methods Based on Observational Diagnosis and Cloud Model Simulation 被引量:9
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作者 Miao CAI Yuquan ZHOU +6 位作者 Jianzhao LIU Chao TAN Yahui TANG Qianrong MA Qi LI Jietai MAO Zhijin HU 《Journal of Meteorological Research》 SCIE CSCD 2020年第6期1256-1270,共15页
Based on the concepts of cloud water resource(CWR)and related variables proposed in the first part of this study,this paper provides details of two methods to quantify the CWR.One is diagnostic quantification(CWR-DQ)b... Based on the concepts of cloud water resource(CWR)and related variables proposed in the first part of this study,this paper provides details of two methods to quantify the CWR.One is diagnostic quantification(CWR-DQ)based on satellite observations,precipitation products,and atmospheric reanalysis data;and the other is numerical quantification(CWR-NQ)based on a cloud resolving model developed at the Chinese Academy of Meteorological Sciences(CAMS).The two methods are applied to quantify the CWR in April and August 2017 over North China,and the results are evaluated against all available observations.Main results are as follows.(1)For the CWR-DQ approach,reference cloud profiles are firstly derived based on the Cloud Sat/CALIPSO joint satellite observations for 2007–2010.The NCEP/NCAR reanalysis data in 2000–2017 are then employed to produce three-dimensional cloud fields.The budget/balance equations of atmospheric water substance are lastly used,together with precipitation observations,to retrieve CWR and related variables.It is found that the distribution and vertical structure of clouds obtained by the diagnostic method are consistent with observations.(2)For the CWR-NQ approach,it assumes that the cloud resolving model is able to describe the cloud microphysical processes completely and precisely,from which four-dimensional distributions of atmospheric water vapor,hydrometeors,and wind fields can be obtained.The data are then employed to quantify the CWR and related terms/quantities.After one-month continuous integration,the mass of atmospheric water substance becomes conserved,and the tempospatial distributions of water vapor,hydrometeors/cloud water,and precipitation are consistent with observations.(3)Diagnostic values of the difference in the transition between hydrometeors and water vapor(Cvh-Chv)and the surface evaporation(Es)are well consistent with their numerical values.(4)Correlation and bias analyses show that the diagnostic CWR contributors are well correlated with observations,and match their numerical counterparts as well,indicating that the CWR-NQ and CWR-DQ methods are reasonable.(5)Underestimation of water vapor converted from hydrometeors(Chv)is a shortcoming of the CWR-DQ method,which may be rectified by numerical quantification results or by use of advanced observations on higher spatiotemporal resolutions. 展开更多
关键词 cloud water resource(CWR) atmospheric hydrometeors precipitation efficiency quantification method observation diagnosis cloud model simulation
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Two-Dimensional Static Numerical Modeling and Simulation of AlGaN/GaN HEMT
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作者 薛丽君 夏洋 +6 位作者 刘明 王燕 邵雪 鲁净 马杰 谢常青 余志平 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2006年第2期298-303,共6页
AIGaN/GaN HEMTs are investigated by numerical simulation from the self-consistent solution of Schr6dinger-Poisson-hydrodynamic (HD) systems. The influences of polarization charge and quantum effects are considered i... AIGaN/GaN HEMTs are investigated by numerical simulation from the self-consistent solution of Schr6dinger-Poisson-hydrodynamic (HD) systems. The influences of polarization charge and quantum effects are considered in this model. Then the two-dimensional conduction band and electron distribution, electron temperature characteristics, Id versus Vd and Id versus Vg, transfer characteristics and transconductance curves are obtained. Corresponding analysis and discussion based on the simulation results are subsequently given. 展开更多
关键词 AIGaN/GaN HEMT 2D modeling and simulation polarization charges quantum effects
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Methods of Validating Simulation Model and Program Design
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作者 陈利 张庆明 +1 位作者 王晓英 汪于力 《Journal of Beijing Institute of Technology》 EI CAS 2002年第2期125-128,共4页
Validating simulation model is one of the important aspects for modeling and simulation. Some methods of validating model are compared and analyzed. Several typical methods, such as TIC’s inequality coefficient, gray... Validating simulation model is one of the important aspects for modeling and simulation. Some methods of validating model are compared and analyzed. Several typical methods, such as TIC’s inequality coefficient, gray interconnected analysis, direct spectrum estimation, maximum entropy spectral estimation based on Burg or Marple, are chosen and programmed in C language. Some examples by using the program are given. The results show that the program is available and it is best to adopt multi methods for validating models. 展开更多
关键词 VALIDATION simulation model interconnected analysis frequency spectrum estimation
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Quantifying Responses of Winter Wheat Physiological Processes to Soil Water Stress for Use in Growth Simulation Modeling 被引量:43
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作者 HUJi-Chao CAOWei-Xing +2 位作者 ZHANGJia-Bao JIANGDong FENGJie 《Pedosphere》 SCIE CAS CSCD 2004年第4期509-518,共10页
A deep understanding of crop-water eco-physiological relations is the basis for quantifying plant physiological responses to soil water stress. Pot experiments were conducted to investigate the winter wheat crop-water... A deep understanding of crop-water eco-physiological relations is the basis for quantifying plant physiological responses to soil water stress. Pot experiments were conducted to investigate the winter wheat crop-water relations under both drought and waterlogging conditions in two sequential growing seasons from 2000 to 2002, and then the data were used to develop and validate models simulating the responses of winter wheat growth to drought and waterlogging stress. The experiment consisted of four treatments, waterlogging (keep 1 to 2 cm water layer depth above soil surface), control (70%-80% field capacity), light drought (40%-50% field capacity) and severe drought (30%-40% field capacity) with six replicates at five stages in the 2000-2001 growth season. Three soil water content treatments (waterlogging, control and drought) with two replicates were designed in the 2001-2002 growth season. Waterlogging and control treatments are the same as in the 2000-2001 growth season. For the drought treatment, no water was supplied and the soil moisture decreased from field capacity to wilting point. Leaf net photosynthetic rate, transpiration rate, predawn leaf water potential, soil water potential, soil water content and dry matter weight of individual organs were measured. Based on crop-water eco-physiological relations, drought and waterlogging stress factors for winter wheat growth simulation model were put forward. Drought stress factors integrated soil water availability, the sensitivity of different development stages and the difference between physiological processes (such as photosynthesis, transpiration and partitioning). The quantification of waterlogging stress factor considered different crop species, soil water status, waterlogging days and sensitivity at different growth stages. Data sets from the pot experiments revealed favorable performance reliability for the simulation sub-models with the drought and waterlogging stress factors. 展开更多
关键词 crop simulation model DROUGHT water stress factor WATERLOGGING winterwheat
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Rice Yield Estimation by Integrating Remote Sensing with Rice Growth Simulation Model 被引量:23
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作者 O.ABOU-ISMAIL 《Pedosphere》 SCIE CAS CSCD 2004年第4期519-526,共8页
Since remote sensing can provide information on the actual status of an agricultural crop, the integration between remote sensing data and crop growth simulation models has become an important trend for yield estimati... Since remote sensing can provide information on the actual status of an agricultural crop, the integration between remote sensing data and crop growth simulation models has become an important trend for yield estimation and prediction.The main objective of this research was to combine a rice growth simulation model with remote sensing data to estimate rice grain yield for different growing seasons leading to an assessment of rice yield at regional levels. Integration between NOAA (National Oceanic and Atmospheric Administration) AVHRR (Advanced Very High Resolution Radiometer) data and the rice growth simulation model ORYZA1 to develop a new software, which was named as Rice-SRS Model, resulted in accurate estimates for rice yield in Shaoxing, China, with an estimation error reduced to 1.03% and 0.79% over-estimation and 0.79% under-estimation for early, single and late season rice, respectively. Selecting suitable dates for remote sensing images was an important factor which could influence estimation accuracy. Thus, given the different growing periods for each rice season, four images were needed for early and late rice, while five images were preferable for single season rice.Estimating rice yield using two or three images was possible, however, if images were obtained during the panicle initiation and heading stages. 展开更多
关键词 remote sensing rice growth simulation model rice yield estimation
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Modeling and simulation for individualized therapy of amisulpride in Chinese patients with schizophrenia:focus on inter interindi⁃vidual variability,therapeutic reference range and laboratory alert level 被引量:7
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作者 HUANG Shan-qing LI Lu +7 位作者 WANG Zhan-zhang XIAO Tao LI Xiao-lin LIU Shu-jing ZHANG Ming LU Hao-yang WEN Yu-guan SHANG De-wei 《中国药理学与毒理学杂志》 CAS 北大核心 2021年第9期661-662,共2页
OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese pa... OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese patients with schizophrenia was built based on therapeu⁃tic drug monitoring data to guide individualized therapy.METHODS Plasma concentration data(330 measurements from 121 patients)were ana⁃lyzed using a nonlinear mixed-effects model⁃ing approach with first-order conditional estima⁃tion with interaction(FOCE I).The concentra⁃tions of amisulpride were detected by HPLC-MS/MS.Age,weight,sex,combination medication history and renal function status were evaluated as main covariates.The model was internally val⁃idated using goodness-of-fit,bootstrap and nor⁃malized prediction distribution error.Recom⁃mended dosage regimens for patients with key covariates were estimated on the basis of Monte Carlo simulations and the established model.RESULTS A one-compartment model with first-order absorption and elimination was found to adequately characterize amisulpride concentra⁃tion in Chinese patients with schizophrenia.The population estimates of the apparent volume of distribution(V/F)and apparent clearance(CL/F)were 12.7 L and 1.12 L·h-1,respectively.Age sig⁃nificantly affected the clearance of amisulpride and the final model was as follow:CL/F=1.04×(AGE/32)-0.624(L·h-1).To avoid exceeding the lab⁃oratory alert level(640μg·L-1),the model-based simulation results showed that the recommended dose of amisulpride was no more than 600 mg per day for patients aged 60 years,800 mg per day for those aged 40 years and 1200 mg per day for those aged 20 years,respectively.CON⁃CLUSION Dosage optimization of amisulpride can be carried out according to age to reduce the risk of adverse reactions.The model can be used as a suitable tool for designing individual⁃ized therapy for Chinese patients with schizo⁃phrenia. 展开更多
关键词 AMISULPRIDE population pharmacoki⁃netics therapeutic drug monitoring modeling and simulation individualized therapy
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A Numerical Convex Lens for the State-Discretized Modeling and Simulation of Megawatt Power Electronics Systems as Generalized Hybrid Systems 被引量:6
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作者 Bochen Shi Zhengming Zhao +2 位作者 Yicheng Zhu Zhujun Yu Jiahe Ju 《Engineering》 SCIE EI 2021年第12期1766-1777,共12页
Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatica... Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatically challenge state-of-the-art modeling and simulation approaches.Such complicated systems,which are composed of not only continuous states but also discrete events,and which contain complex dynamics across multiple timescales,are defined as generalized hybrid systems(GHSs)in this paper.As a representative GHS,megawatt power electronics(MPE)systems have been largely integrated into the modern power grid,but MPE simulation remains a bottleneck due to its unacceptable time cost and poor convergence.To address this challenge,this paper proposes the numerical convex lens approach to achieve state-discretized modeling and simulation of GHSs.This approach transforms conventional time-discretized passive simulations designed for pure-continuous systems into state-discretized selective simulations designed for GHSs.When this approach was applied to a largescale MPE-based renewable energy system,a 1000-fold increase in simulation speed was achieved,in comparison with existing software.Furthermore,the proposed approach uniquely enables the switching transient simulation of a largescale megawatt system with high accuracy,compared with experimental results,and with no convergence concerns.The numerical convex lens approach leads to the highly efficient simulation of intricate GHSs across multiple timescales,and thus significantly extends engineers’capability to study systems with numerical experiments. 展开更多
关键词 Generalized hybrid systems Megawatt power electronics modeling and simulation Numerical convex lens
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A review of modeling,simulation,and control technologies of altitude ground test facilities for control application 被引量:5
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作者 Xitong PEI Xi WANG +6 位作者 Jiashuai LIU Meiyin ZHU Zhihong DAN Ai HE Keqiang MIAO Louyue ZHANG Zheng XU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第9期38-62,共25页
As the pivotal test equipment of aero-engines design,finalization,improvement,modification,etc.,the Altitude Ground Test Facilities(AGTF)plays an important role in the research and development of the aero-engines.With... As the pivotal test equipment of aero-engines design,finalization,improvement,modification,etc.,the Altitude Ground Test Facilities(AGTF)plays an important role in the research and development of the aero-engines.With the rapid development of advanced high-performance aeroengine,the increasing demand of high-altitude simulation test is driving AGTF to improve its test ability and level of automation and intelligence.The modeling method,simulation tool,and control technology are the key factors to support the improvement of the AGTF control system.The main purpose of this paper is to provide an overview of modeling methods,simulation tools,and control technologies in AGTF control system for future research.First,it reviews the evolution of AGTF in the world,from the early formative stage to integration stage.Then,the mathematical modeling method of AGTF for control application is overviewed.Furthermore,the simulation tools used in the AGTF control system are overviewed from numerical simulation to hardware-in-loop simulation and further to semi-physical simulation.Meanwhile,the control technologies used in the AGTF control system are summarized from single-variable control to multivariable integrated control,and from classical control theory to modern control theory.Finally,recommendations for future research are outlined.Therefore,this review article provides extensive literature information for the modeling,simulation,and control design of AGTF for control application. 展开更多
关键词 Altitude ground test facilities Control system modeling and simulation Robust control Temperature and pressure control
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Plant Temperature and Its Simulation Model of Thermo-Sensitive Genic Male Sterile Rice 被引量:6
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作者 LU Chuan-gen XIA Shi-jian +2 位作者 CHEN Jing Hu Ning YAO Ke-min 《Rice science》 SCIE 2008年第3期223-231,共9页
Plant temperature (Tp) and its relations to the microclimate of rice colony and irrigation water were studied using a thermo-sensitive genic male sterile (TGMS) rice line, Pei'ai 64S. Significant differences in t... Plant temperature (Tp) and its relations to the microclimate of rice colony and irrigation water were studied using a thermo-sensitive genic male sterile (TGMS) rice line, Pei'ai 64S. Significant differences in the daily change of temperature were detected between Tp and air temperature at the height of 150 cm (TA). From 8:00 to 20:00, Tp was lower than TA, but they were similar during 21:00 to next 7:00. The maximum Tp occurred one hour earlier than the maximum TA, though they both reached the minimum at 6:00. Tp fluctuated less than TA. At the same height, during 6:00-13:00, Tp was higher than air temperature (Ta), and Tp reached the maximum one hour earlier than Ta. During the rest time on sunny day, Tp was close to or even a little lower than Ta. On overcast day, Tp was higher than Ta in the whole day, and both maximized at the same time. In addition, Tp was regulated by solar radiation, cloudage and wind speed in daytime, and by irrigation water at night. The present study indicated that a TA of 29.6℃ was the critical point, at which Tp was increased or decreased by irrigation water. Tp and the difference between water and air temperatures showed a conic relation. Tp fluctuation was also regulated by the absorption or reflection of solar radiation by leaves during daytime and release of heat energy during nighttime. By analysis on correlation and regression simulation, two models of Tp were established. 展开更多
关键词 RICE plant temperature air temperature simulation model thermo-sensitive genic male sterility
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A New Method with High Confidence for Validation of Computer Simulation Models of Flight Systems 被引量:5
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作者 Zhou XianminShanghai Research & Development Centre, 412 Guil in Road, Shanghai 200233, P.R.China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1993年第4期43-52,共10页
Computer simulation models may by used to gain further information about missile performance variability. Model validation is an important aspect of the test program for a missile system. Validation provides a basis f... Computer simulation models may by used to gain further information about missile performance variability. Model validation is an important aspect of the test program for a missile system. Validation provides a basis for confidence in the model's results and is a necessary step if the model is to be used to draw inference about the behavior of the real missile. This paper is a review of methods useful for validation of computer simulation models of missile systems and provides a new method with high degree of confidence for validation of computer simulation models of missile systems. Some examples of the use of the new method in validating computer simulation models are given. 展开更多
关键词 model validation model credibility simulation modeling System simulation.
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Research on system-of-systems combat simulation model formal specification and representation 被引量:3
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作者 Liu Chen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2006年第4期901-909,共9页
To makesystem-of-systems combat simulation models easy to be developed and reused, simulation model formal specification and representation are researched. According to the view of system-of-systems combat simulation,... To makesystem-of-systems combat simulation models easy to be developed and reused, simulation model formal specification and representation are researched. According to the view of system-of-systems combat simulation, and based on DEVS, the simulation model's fundamental formalisms are explored. It includes entity model, system-of-systems model and experiment model. It also presents rigorous formal specification. XML data exchange standard is combined to design the XML based language, SCSL, to support simulation model representation. The corresponding relationship between SCSL and simulation model formalism is discussed and the syntax and semantics of elements in SCSL are detailed. Based on simulation model formal specification, the abstract simulation algorithm is given and SCSL virtual machine, which is capable of automatically interpreting and executing simulation model represented by SCSL, is designed. Finally an application case is presented, which can show the validation of the theory and verification of SCSL. 展开更多
关键词 simulation model formalism simulation model representation system-of-systems combat simulation language simulation virtual machine.
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