Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the inju...Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the injury and pathophysiological mechanisms underlying PCAS remain unclear.Experimental animal models are valuable tools for exploring the etiology,pathogenesis,and potential interventions for CA and PCAS.Current CA animal models include electrical induction of ventricular fibrillation(VF),myocardial infarction,high potassium,asphyxia,and hemorrhagic shock.Although these models do not fully replicate the complexity of clinical CA,the mechanistic insights they provide remain highly relevant,including post-CA brain injury(PCABI),post-CA myocardial dysfunction(PAMD),systemic ischaemia/reperfusion injury(IRI),and the persistent precipitating pathology.Summarizing the methods of establishing CA models,the challenges encountered in the modeling process,and the mechanisms of PCAS can provide a foundation for developing standardized CA modeling protocols.展开更多
The most reliable archive of atmospheric CO_(2) information comprises ice core records spanning the last 800 ka(thousand years ago).The connection between temperature and greenhouse gases,as deduced from ice core reco...The most reliable archive of atmospheric CO_(2) information comprises ice core records spanning the last 800 ka(thousand years ago).The connection between temperature and greenhouse gases,as deduced from ice core records,may help better simulate CO_(2) variations.This research aimed to explore the model methods to precisely predict the atmospheric CO_(2) concentrations and fill the CO_(2) data gaps with CH4 concentration and temperature proxies(δD andδ18O)from Antarctica ice cores,employing Artificial Neural Network(ANN)and Wavelet Transform(WT)techniques.This study was divided into three sections to examine various timescales and resolutions.First,coarse-resolution CO_(2) records from the Vostok and EPICA Dronning Maud Land cores from 70–120 ka were used.Second,the models were applied to the Dome Fuji core for 9–120 ka.Finally,a high-resolution West Antarctic Ice Sheet(WAIS)Divide ice core record,focusing on the 9–70 ka,was employed.The results showed that between 70–120 ka,the hybrid method surpasses the traditional ANN approach.The hybrid method maintained superior performance in the last phase by utilizing high-resolution WAIS record.The results indicated improved accuracy(r=0.98),reinforcing the notion that hybrid methods yield better outcomes than those relying solely on AI methods.展开更多
3-D geological modeling plays an increasingly important role in Petroleum Geology, Mining Geology and Engineering Geology. The complexity of geological conditions requires different modeling methods in different situa...3-D geological modeling plays an increasingly important role in Petroleum Geology, Mining Geology and Engineering Geology. The complexity of geological conditions requires different modeling methods in different situations. This paper summarizes the general concept of geological modeling; compares the characteristics of borehole-based modeling, cross-section based modeling and multi- source interactive modeling; analyses key techniques in 3-D geological modeling; and highlights the main difficulties and directions of future studies.展开更多
Two modeling methods of the root insert for wind turbine blade are presented,i.e.,the local mesh optimization method(LMOM)and the global modeling method(GMM).Based on the optimized mesh of the local model for the meta...Two modeling methods of the root insert for wind turbine blade are presented,i.e.,the local mesh optimization method(LMOM)and the global modeling method(GMM).Based on the optimized mesh of the local model for the metal contact interface,LMOM is proposed to analyze the load path and stress distribution characteristics,while GMM is used to calculate and analyze the stress distribution characteristics of the resin layer established between the bushing and composite layers of root insert.To validate the GMM,a tension test is carried out.The result successfully shows that the shear strain expresses a similar strain distribution tendency with the GMM′s results.展开更多
In this paper,the static output feedback stabilization for large-scale unstable second-order singular systems is investigated.First,the upper bound of all unstable eigenvalues of second-order singular systems is deriv...In this paper,the static output feedback stabilization for large-scale unstable second-order singular systems is investigated.First,the upper bound of all unstable eigenvalues of second-order singular systems is derived.Then,by using the argument principle,a computable stability criterion is proposed to check the stability of secondorder singular systems.Furthermore,by applying model reduction methods to original systems,a static output feedback design algorithm for stabilizing second-order singular systems is presented.A simulation example is provided to illustrate the effectiveness of the design algorithm.展开更多
With the increasing demand for energy conservation and emission reduction,more attentions have been paid to the intelligentization,greenization and low carbonization during the transformation and upgrading of steelmak...With the increasing demand for energy conservation and emission reduction,more attentions have been paid to the intelligentization,greenization and low carbonization during the transformation and upgrading of steelmaking plants.Ladle furnace(LF)refining is one of the key procedures in steelmaking process and has been widely used in steelmaking plants for its high equipment matching degree,low equipment investment and outstanding refining performance.According to the main tasks of LF refining process,the modeling methods of temperature prediction model,slag-making model,alloying model,argon blowing model and model of inclusions behavior were systematically reviewed,and the advantages and disadvantages of each modeling method were summarized.In addition,the technical framework for the future has also been proposed based on existing works,including classification of raw materials,graphic representation of knowledge,introduction,upgradation and management of device/equipment,customization of steelmaking,modeling of refining process,synergy of models,intelligentization of decision-making,automation of control,and digitization of processes and operations,aiming to provide a reference for the modeling and intelligent development of LF refining process.展开更多
Experimental stroke research commonly employs focal cerebral ischemic rat models （Bederson et al., 1986a; Longa et al., 1989）. In human patients, ischemic stroke typically results from thrombotic or embolic occlusio...Experimental stroke research commonly employs focal cerebral ischemic rat models （Bederson et al., 1986a; Longa et al., 1989）. In human patients, ischemic stroke typically results from thrombotic or embolic occlusion of a major cerebral artery, usually the mid- dle cerebral artery （MCA）. Experimental focal cerebral ischemia models have been employed to mimic human stroke （Durukan and Tatlisumak, 2007）. Rodent models of focal cerebral ischemia that do not require craniotomy have been developed using intraluminal suture occlusion of the MCA （MCA occlusion, MCAO） （Rosamond et al., 2008）. Furthermore, mouse MCAO models have been wide- ly used and extended to genetic studies of cell death or recovery mechanisms （Liu and McCullough, 2011）. Genetically engineered mouse stroke models are particularly useful for evaluation of isch- emic pathophysiology and the design of new prophylactic, neuro- protective, and therapeutic agents and interventions （Armstead et al., 2010）. During the past two decades, MCAO surgical techniques have been developed that do not reveal surgical techniques for mouse MCAO model engineering. Therefore, we compared MCAO surgical methods in rats and mice.展开更多
N-11-azaartemisinins potentially active against Plasmodium falciparum are designed by combining molecular electrostatic potential (MEP), ligand-receptor interaction, and models built with supervised machine learning m...N-11-azaartemisinins potentially active against Plasmodium falciparum are designed by combining molecular electrostatic potential (MEP), ligand-receptor interaction, and models built with supervised machine learning methods (PCA, HCA, KNN, SIMCA, and SDA). The optimization of molecular structures was performed using the B3LYP/6-31G* approach. MEP maps and ligand-receptor interactions were used to investigate key structural features required for biological activities and likely interactions between N-11-azaartemisinins and heme, respectively. The supervised machine learning methods allowed the separation of the investigated compounds into two classes: cha and cla, with the properties ε<sub>LUMO+1</sub> (one level above lowest unoccupied molecular orbital energy), d(C<sub>6</sub>-C<sub>5</sub>) (distance between C<sub>6</sub> and C<sub>5</sub> atoms in ligands), and TSA (total surface area) responsible for the classification. The insights extracted from the investigation developed and the chemical intuition enabled the design of sixteen new N-11-azaartemisinins (prediction set), moreover, models built with supervised machine learning methods were applied to this prediction set. The result of this application showed twelve new promising N-11-azaartemisinins for synthesis and biological evaluation.展开更多
On the basis of introducing the fundamental theory and the basic analysis steps of the sub model method, the strength of the new engine complex assembly structure was analyzed according to the properties of the engin...On the basis of introducing the fundamental theory and the basic analysis steps of the sub model method, the strength of the new engine complex assembly structure was analyzed according to the properties of the engine structures, some of the key parts of the engine were analyzed with refined mesh by sub model method and the error of the FEM solution was estimated by the extrapolation method. The example showed that the sub model can not only analyze the comlex structures without the restriction of the software and hardware of the computers, but get the more precise analysis result also. This method is more suitable for the strength analysis of the complex assembly structure.展开更多
Accurate estimations of animal population size are pivotal for implementing management strategies properly.Recapture technique based on sounds as a specimen identifcation mark has barely been used for marine mammals.H...Accurate estimations of animal population size are pivotal for implementing management strategies properly.Recapture technique based on sounds as a specimen identifcation mark has barely been used for marine mammals.However,inferring abundance estimates from acoustic methods could enhance the accuracy and precision of population size assessments.Here,we tested the possibility of using signature whistles as individual marks for estimating the size of common bottlenose dolphin(Tursiops truncatus)populations.Data were continuously collected for 326 days in 2015–2016,by using a fxed acoustic device located in the Sicily Strait(Italy).The SIGID method was applied to identify Signature Whistles Types(SWTs)over 7,000 h of recordings.Eighty SWTs were detected as long as their stereotyped fundamental frequency contours were repeated in bouts of at least 6 renditions.The mean SWTs monthly recording rate resulted in 0.19(Standard deviation=0.16),with 20 SWTs recorded over 5 or more different encounters(until a maximum of 30 encounters).The Jolly–Seber model(with POPAN formulation)was run in Mark software to estimate the population size.The estimated population size resulted in 171 bottlenose dolphins(95%confdence interval=137–215).Even if the detection and identifcation of signature whistles required crucial precautions,and animals could be detected differently from visual techniques,the population size estimate obtained was comparable with previous results based on physical marks data.These outcomes demonstrated that signature whistles can be considered a strongly effective tool for integrating traditional mark-recapture techniques with fnely estimated dolphins’population abundances.展开更多
Developing an accurate and efficient comprehensive water quality prediction model and its assessment method is crucial for the prevention and control of water pollution.Deep learning(DL),as one of the most promising t...Developing an accurate and efficient comprehensive water quality prediction model and its assessment method is crucial for the prevention and control of water pollution.Deep learning(DL),as one of the most promising technologies today,plays a crucial role in the effective assessment of water body health,which is essential for water resource management.This study models using both the original dataset and a dataset augmented with Generative Adversarial Networks(GAN).It integrates optimization algorithms(OA)with Convolutional Neural Networks(CNN)to propose a comprehensive water quality model evaluation method aiming at identifying the optimal models for different pollutants.Specifically,after preprocessing the spectral dataset,data augmentation was conducted to obtain two datasets.Then,six new models were developed on these datasets using particle swarm optimization(PSO),genetic algorithm(GA),and simulated annealing(SA)combined with CNN to simulate and forecast the concentrations of three water pollutants:Chemical Oxygen Demand(COD),Total Nitrogen(TN),and Total Phosphorus(TP).Finally,seven model evaluation methods,including uncertainty analysis,were used to evaluate the constructed models and select the optimal models for the three pollutants.The evaluation results indicate that the GPSCNN model performed best in predicting COD and TP concentrations,while the GGACNN model excelled in TN concentration prediction.Compared to existing technologies,the proposed models and evaluation methods provide a more comprehensive and rapid approach to water body prediction and assessment,offering new insights and methods for water pollution prevention and control.展开更多
Introduction Types of paper Contributions falling into the following categories will be considered for publication:original articles,review articles,short letters,modelling/theory and methods articles,rapid reports an...Introduction Types of paper Contributions falling into the following categories will be considered for publication:original articles,review articles,short letters,modelling/theory and methods articles,rapid reports and special thematic issues.Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.展开更多
The hot spot temperature of a transformer is one of the critical indicators reflecting its operating status.Accurate and fast calculation of hot spot temperature is significant for the online monitoring of transformer...The hot spot temperature of a transformer is one of the critical indicators reflecting its operating status.Accurate and fast calculation of hot spot temperature is significant for the online monitoring of transformers.Considering the low computational efficiency of the transformer’s numerical full model(FM),this paper presents a model simplification method based on the equivalent thermal parameters of windings to expedite hot spot temperature computation.Initially,the representative volume element(RVE)reflecting the periodic structure of windings is selected to formulate a reduced model(RM)for the transformer.Subsequently,to achieve equivalence between the RM and the FM,the equivalent thermal parameters of the RVE are calculated,containing the equivalent thermal conductivity(ETC),the equivalent density(ED),and the equivalent specific heat capacity(ESHC).Finally,the validity of the RM is verified by the temperature rise test.The results show that,compared with the tested data,the maximum error of the hot spot temperature calculated by the RM is 2.56 K,demonstrating the accuracy of the hot spot temperature calculation by the RM.Compared with the FM,the computing time of the proposed RM is reduced to 1/189,which significantly improves the computational efficiency.展开更多
An optical emission spectroscopy(OES)method with a non-invasive measurement capability,without inducing disturbance to the discharge,represents an effective method for material monitoring.However,when the OES method i...An optical emission spectroscopy(OES)method with a non-invasive measurement capability,without inducing disturbance to the discharge,represents an effective method for material monitoring.However,when the OES method is employed to monitor the trace erosion product within the ceramic channel of a Hall thruster,it becomes challenging to distinguish between signal and noise.In this study,we propose a model filtering method based on the signal characteristics of the Hall thruster plume spectrometer.This method integrates the slit imaging and spectral resolution features of the spectrometer.Employing this method,we extract the spectral signals of the erosion product and working gas from the Hall thruster under different operating conditions.The results indicate that our new method performs comparably to the traditional method without model filtering when extracting atom signals from strong xenon working gas.However,for trace amounts of the erosion product,our approach significantly enhances the signal-to-noise ratio(SNR),enabling the identification of extremely weak spectral signals even under low mass flow rate and low-voltage conditions.We obtain boron atom concentration of 3.91×10^(-3) kg/m^(3) at a mass flow rate of 4×10^(-7) kg/s and voltage of 200 V while monitoring a wider range of thruster operating conditions.The new method proposed in this study is suitable for monitoring other low-concentration elements,making it valuable for materials processing,environmental monitoring and space propulsion applications.展开更多
To fundamentally alleviate the excavation chamber clogging during slurry tunnel boring machine(TBM)advancing in hard rock,large-diameter short screw conveyor was adopted to slurry TBM of Qingdao Jiaozhou Bay Second Un...To fundamentally alleviate the excavation chamber clogging during slurry tunnel boring machine(TBM)advancing in hard rock,large-diameter short screw conveyor was adopted to slurry TBM of Qingdao Jiaozhou Bay Second Undersea Tunnel.To evaluate the discharging performance of short screw conveyor in different cases,the full-scale transient slurry-rock two-phase model for a short screw conveyor actively discharging rocks was established using computational fluid dynamics-discrete element method(CFD-DEM)coupling approach.In the fluid domain of coupling model,the sliding mesh technology was utilized to describe the rotations of the atmospheric composite cutterhead and the short screw conveyor.In the particle domain of coupling model,the dynamic particle factories were established to produce rock particles with the rotation of the cutterhead.And the accuracy and reliability of the CFD-DEM simulation results were validated via the field test and model test.Furthermore,a comprehensive parameter analysis was conducted to examine the effects of TBM operating parameters,the geometric design of screw conveyor and the size of rocks on the discharging performance of short screw conveyor.Accordingly,a reasonable rotational speed of screw conveyor was suggested and applied to Jiaozhou Bay Second Undersea Tunnel project.The findings in this paper could provide valuable references for addressing the excavation chamber clogging during ultra-large-diameter slurry TBM tunneling in hard rock for similar future.展开更多
The shape of strip is calculated by iterative method which combines strip plastic deformation model with rolls elastic deformation model through their calculation results, which can be called results coupling method. ...The shape of strip is calculated by iterative method which combines strip plastic deformation model with rolls elastic deformation model through their calculation results, which can be called results coupling method. Be- cause the shape and rolling force distribution are very sensitive to strip thickness transverse distribution% variation, the iterative course is rather unstable and sometimes convergence cannot be achieved. In addition, the calculating speed of results coupling method is low, which restricts its usable range. To solve the problem, a new model cou- pling method is developed, which takes the force distribution between rolls, rolling force distribution and strip＇s exit transverse displacement distribution as basic unknowns, and integrates strip plastic deformation model and rolls elas- tic deformation model as a unified linear equations through their internal relation, so the iterative calculation between the strip plastic deformation model and rolls elastic deformation model can be avoided. To prove the effectiveness of the model coupling method, two examples are calculated by results coupling method and model coupling method re- spectively. The results of front tension stress, back tension stress, strip^s exit gauge, the force between rolls and rolling force distribution calculated by model coupling method coincide very well with results coupling method. How- ever the calculation course of model coupling method is more steady than results coupling method, and its calculating speed is about ten times as much as the maximal speed of results coupling method, which validates its practicability and reliability.展开更多
Spastic cerebral palsy is generally considered to result from cerebral cortical or pyramidal tract damage. Here, we precisely targeted the left pyramidal tract of 2-month-old Sprague-Dawley rats placed on a stereotaxi...Spastic cerebral palsy is generally considered to result from cerebral cortical or pyramidal tract damage. Here, we precisely targeted the left pyramidal tract of 2-month-old Sprague-Dawley rats placed on a stereotaxic instrument under intraperitoneal anesthesia. Based on the rat brain stereotaxic map, a 1-mm hole was made 10 mm posterior to bregma and 0.8 mm left of sagittal suture. A microsyringe was inserted perpendicularly to the surface of the brain to a depth of 9.7 mm, and 15 wL of ethanol was slowly injected to establish a rat model of spastic cerebral palsy. After modeling, the rats appeared to have necrotic voids in the pyramidal tract and exhibited typical signs and symptoms of flexion spasms that lasted for a long period of time. These findings indicate that this is an effective and easy method of establishing a rat model of spastic cerebral palsy with good reproducibility. Ethanol as a chemical ablation agent specifically and thoroughly damages the py- ramidal tract, and therefore, the animals display flexion spasms, which are a typical symptom of the disease.展开更多
Dynamic modeling for incompressible hyperelastic materials with large deformation is an important issue in biomimetic applications. The previously proposed lower-order fully parameterized absolute nodal coordinate for...Dynamic modeling for incompressible hyperelastic materials with large deformation is an important issue in biomimetic applications. The previously proposed lower-order fully parameterized absolute nodal coordinate formulation（ANCF） beam element employs cubic interpolation in the longitudinal direction and linear interpolation in the transverse direction, whereas it cannot accurately describe the large bending deformation. On this account, a novel modeling method for studying the dynamic behavior of nonlinear materials is proposed in this paper. In this formulation, a higher-order beam element characterized by quadratic interpolation in the transverse directions is used in this investigation. Based on the Yeoh model and volumetric energy penalty function, the nonlinear elastic force matrices are derived within the ANCF framework. The feasibility and availability of the Yeoh model are verified through static experiment of nonlinear incompressible materials. Furthermore,dynamic simulation of a silicone cantilever beam under the gravity force is implemented to validate the superiority of the higher-order beam element. The simulation results obtained based on the Yeoh model by employing three different ANCF beam elements are compared with the result achieved from a commercial finite element package as the reference result. It is found that the results acquired utilizing a higher-order beam element are in good agreement with the reference results,while the results obtained using a lower-order beam element are different from the reference results. In addition, the stiffening problem caused by volumetric locking can be resolved effectively by applying a higher-order beam element. It is concluded that the proposed higher-order beam element formulation has satisfying accuracy in simulating dynamic motion process of the silicone beam.展开更多
In order to establish an adaptive turbo-shaft engine model with high accuracy, a new modeling method based on parameter selection （PS） algorithm and multi-input multi-output recursive reduced least square support ve...In order to establish an adaptive turbo-shaft engine model with high accuracy, a new modeling method based on parameter selection （PS） algorithm and multi-input multi-output recursive reduced least square support vector regression （MRR-LSSVR） machine is proposed. Firstly, the PS algorithm is designed to choose the most reasonable inputs of the adaptive module. During this process, a wrapper criterion based on least square support vector regression （LSSVR） machine is adopted, which can not only reduce computational complexity but also enhance generalization performance. Secondly, with the input variables determined by the PS algorithm, a mapping model of engine parameter estimation is trained off-line using MRR-LSSVR, which has a satisfying accuracy within 5＆. Finally, based on a numerical simulation platform of an integrated helicopter/ turbo-shaft engine system, an adaptive turbo-shaft engine model is developed and tested in a certain flight envelope. Under the condition of single or multiple engine components being degraded, many simulation experiments are carried out, and the simulation results show the effectiveness and validity of the proposed adaptive modeling method.展开更多
基金supported by the National Key Research and Development Program(2021YFC3002205)the Postgraduate Research and Innovation Program of Tianjin Municipal Education Commission(2022BKY113),China.
文摘Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the injury and pathophysiological mechanisms underlying PCAS remain unclear.Experimental animal models are valuable tools for exploring the etiology,pathogenesis,and potential interventions for CA and PCAS.Current CA animal models include electrical induction of ventricular fibrillation(VF),myocardial infarction,high potassium,asphyxia,and hemorrhagic shock.Although these models do not fully replicate the complexity of clinical CA,the mechanistic insights they provide remain highly relevant,including post-CA brain injury(PCABI),post-CA myocardial dysfunction(PAMD),systemic ischaemia/reperfusion injury(IRI),and the persistent precipitating pathology.Summarizing the methods of establishing CA models,the challenges encountered in the modeling process,and the mechanisms of PCAS can provide a foundation for developing standardized CA modeling protocols.
基金supported by the Brain Pool Program through the National Research Foundation of Korea(NRF)and funded by the Ministry of Science and ICT[Grant numbers:2020H1D3A1A04081353,2020M1A5A1110607,2018R1A5A1024958,and RS-2023-00291696].
文摘The most reliable archive of atmospheric CO_(2) information comprises ice core records spanning the last 800 ka(thousand years ago).The connection between temperature and greenhouse gases,as deduced from ice core records,may help better simulate CO_(2) variations.This research aimed to explore the model methods to precisely predict the atmospheric CO_(2) concentrations and fill the CO_(2) data gaps with CH4 concentration and temperature proxies(δD andδ18O)from Antarctica ice cores,employing Artificial Neural Network(ANN)and Wavelet Transform(WT)techniques.This study was divided into three sections to examine various timescales and resolutions.First,coarse-resolution CO_(2) records from the Vostok and EPICA Dronning Maud Land cores from 70–120 ka were used.Second,the models were applied to the Dome Fuji core for 9–120 ka.Finally,a high-resolution West Antarctic Ice Sheet(WAIS)Divide ice core record,focusing on the 9–70 ka,was employed.The results showed that between 70–120 ka,the hybrid method surpasses the traditional ANN approach.The hybrid method maintained superior performance in the last phase by utilizing high-resolution WAIS record.The results indicated improved accuracy(r=0.98),reinforcing the notion that hybrid methods yield better outcomes than those relying solely on AI methods.
文摘3-D geological modeling plays an increasingly important role in Petroleum Geology, Mining Geology and Engineering Geology. The complexity of geological conditions requires different modeling methods in different situations. This paper summarizes the general concept of geological modeling; compares the characteristics of borehole-based modeling, cross-section based modeling and multi- source interactive modeling; analyses key techniques in 3-D geological modeling; and highlights the main difficulties and directions of future studies.
基金supported jointly by the National Basic Research Program of China("973"Program)(No2014CB046200)the National Science Foundation of Jiangsu Province(No.BK2014059)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe National Natural Science Foundation of China(No.11172135)
文摘Two modeling methods of the root insert for wind turbine blade are presented,i.e.,the local mesh optimization method(LMOM)and the global modeling method(GMM).Based on the optimized mesh of the local model for the metal contact interface,LMOM is proposed to analyze the load path and stress distribution characteristics,while GMM is used to calculate and analyze the stress distribution characteristics of the resin layer established between the bushing and composite layers of root insert.To validate the GMM,a tension test is carried out.The result successfully shows that the shear strain expresses a similar strain distribution tendency with the GMM′s results.
基金Project supported by the National Natural Science Foundation of China(Nos.11971303 and 11871330)。
文摘In this paper,the static output feedback stabilization for large-scale unstable second-order singular systems is investigated.First,the upper bound of all unstable eigenvalues of second-order singular systems is derived.Then,by using the argument principle,a computable stability criterion is proposed to check the stability of secondorder singular systems.Furthermore,by applying model reduction methods to original systems,a static output feedback design algorithm for stabilizing second-order singular systems is presented.A simulation example is provided to illustrate the effectiveness of the design algorithm.
基金funded by the National Natural Science Foundation of China(Grant Nos.50874014,51974023,52374321)the Program for New Century Excellent Talents in University(Grant No.NCET 07-0067)+1 种基金the Fundamental Research Funds for Central Universities(Grant No.FRF-BR-17-029A)the funding of State Key Laboratory of Advanced Metallurgy,University of Science and Technology Beijing,China(Grant Nos.41620007 and 41621005).
文摘With the increasing demand for energy conservation and emission reduction,more attentions have been paid to the intelligentization,greenization and low carbonization during the transformation and upgrading of steelmaking plants.Ladle furnace(LF)refining is one of the key procedures in steelmaking process and has been widely used in steelmaking plants for its high equipment matching degree,low equipment investment and outstanding refining performance.According to the main tasks of LF refining process,the modeling methods of temperature prediction model,slag-making model,alloying model,argon blowing model and model of inclusions behavior were systematically reviewed,and the advantages and disadvantages of each modeling method were summarized.In addition,the technical framework for the future has also been proposed based on existing works,including classification of raw materials,graphic representation of knowledge,introduction,upgradation and management of device/equipment,customization of steelmaking,modeling of refining process,synergy of models,intelligentization of decision-making,automation of control,and digitization of processes and operations,aiming to provide a reference for the modeling and intelligent development of LF refining process.
基金supported by the 2013 Inje University Research Grant
文摘Experimental stroke research commonly employs focal cerebral ischemic rat models （Bederson et al., 1986a; Longa et al., 1989）. In human patients, ischemic stroke typically results from thrombotic or embolic occlusion of a major cerebral artery, usually the mid- dle cerebral artery （MCA）. Experimental focal cerebral ischemia models have been employed to mimic human stroke （Durukan and Tatlisumak, 2007）. Rodent models of focal cerebral ischemia that do not require craniotomy have been developed using intraluminal suture occlusion of the MCA （MCA occlusion, MCAO） （Rosamond et al., 2008）. Furthermore, mouse MCAO models have been wide- ly used and extended to genetic studies of cell death or recovery mechanisms （Liu and McCullough, 2011）. Genetically engineered mouse stroke models are particularly useful for evaluation of isch- emic pathophysiology and the design of new prophylactic, neuro- protective, and therapeutic agents and interventions （Armstead et al., 2010）. During the past two decades, MCAO surgical techniques have been developed that do not reveal surgical techniques for mouse MCAO model engineering. Therefore, we compared MCAO surgical methods in rats and mice.
文摘N-11-azaartemisinins potentially active against Plasmodium falciparum are designed by combining molecular electrostatic potential (MEP), ligand-receptor interaction, and models built with supervised machine learning methods (PCA, HCA, KNN, SIMCA, and SDA). The optimization of molecular structures was performed using the B3LYP/6-31G* approach. MEP maps and ligand-receptor interactions were used to investigate key structural features required for biological activities and likely interactions between N-11-azaartemisinins and heme, respectively. The supervised machine learning methods allowed the separation of the investigated compounds into two classes: cha and cla, with the properties ε<sub>LUMO+1</sub> (one level above lowest unoccupied molecular orbital energy), d(C<sub>6</sub>-C<sub>5</sub>) (distance between C<sub>6</sub> and C<sub>5</sub> atoms in ligands), and TSA (total surface area) responsible for the classification. The insights extracted from the investigation developed and the chemical intuition enabled the design of sixteen new N-11-azaartemisinins (prediction set), moreover, models built with supervised machine learning methods were applied to this prediction set. The result of this application showed twelve new promising N-11-azaartemisinins for synthesis and biological evaluation.
文摘On the basis of introducing the fundamental theory and the basic analysis steps of the sub model method, the strength of the new engine complex assembly structure was analyzed according to the properties of the engine structures, some of the key parts of the engine were analyzed with refined mesh by sub model method and the error of the FEM solution was estimated by the extrapolation method. The example showed that the sub model can not only analyze the comlex structures without the restriction of the software and hardware of the computers, but get the more precise analysis result also. This method is more suitable for the strength analysis of the complex assembly structure.
基金the project“BIOforIU project PONa3_00025-Multidisciplinary Infrastructure for the Study and Development of Marine and Terrestrial Biodiversity in the Perspective of Innovation Union.”Part of the analysis was funded under the National Recovery and Resilience Plan(NRRP),Mission 4 Component 2 Investment 1.4-Call for tender No.3138 of 16 December 2021,rectifed by Decree n.3175 of 18 December 2021 of Italian Ministry of University and Research funded by the European Union-NextGenerationEU,Award Number:Project code CN_00000033,Concession Decree No.1034 of 17 June 2022 adopted by the Italian Ministry of University and Research,Project title"National Biodiversity Future Center-NBFC".
文摘Accurate estimations of animal population size are pivotal for implementing management strategies properly.Recapture technique based on sounds as a specimen identifcation mark has barely been used for marine mammals.However,inferring abundance estimates from acoustic methods could enhance the accuracy and precision of population size assessments.Here,we tested the possibility of using signature whistles as individual marks for estimating the size of common bottlenose dolphin(Tursiops truncatus)populations.Data were continuously collected for 326 days in 2015–2016,by using a fxed acoustic device located in the Sicily Strait(Italy).The SIGID method was applied to identify Signature Whistles Types(SWTs)over 7,000 h of recordings.Eighty SWTs were detected as long as their stereotyped fundamental frequency contours were repeated in bouts of at least 6 renditions.The mean SWTs monthly recording rate resulted in 0.19(Standard deviation=0.16),with 20 SWTs recorded over 5 or more different encounters(until a maximum of 30 encounters).The Jolly–Seber model(with POPAN formulation)was run in Mark software to estimate the population size.The estimated population size resulted in 171 bottlenose dolphins(95%confdence interval=137–215).Even if the detection and identifcation of signature whistles required crucial precautions,and animals could be detected differently from visual techniques,the population size estimate obtained was comparable with previous results based on physical marks data.These outcomes demonstrated that signature whistles can be considered a strongly effective tool for integrating traditional mark-recapture techniques with fnely estimated dolphins’population abundances.
基金Supported by Natural Science Basic Research Plan in Shaanxi Province of China(Program No.2022JM-396)the Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No.XDA23040101+4 种基金Shaanxi Province Key Research and Development Projects(Program No.2023-YBSF-437)Xi'an Shiyou University Graduate Student Innovation Fund Program(Program No.YCX2412041)State Key Laboratory of Air Traffic Management System and Technology(SKLATM202001)Tianjin Education Commission Research Program Project(2020KJ028)Fundamental Research Funds for the Central Universities(3122019132)。
文摘Developing an accurate and efficient comprehensive water quality prediction model and its assessment method is crucial for the prevention and control of water pollution.Deep learning(DL),as one of the most promising technologies today,plays a crucial role in the effective assessment of water body health,which is essential for water resource management.This study models using both the original dataset and a dataset augmented with Generative Adversarial Networks(GAN).It integrates optimization algorithms(OA)with Convolutional Neural Networks(CNN)to propose a comprehensive water quality model evaluation method aiming at identifying the optimal models for different pollutants.Specifically,after preprocessing the spectral dataset,data augmentation was conducted to obtain two datasets.Then,six new models were developed on these datasets using particle swarm optimization(PSO),genetic algorithm(GA),and simulated annealing(SA)combined with CNN to simulate and forecast the concentrations of three water pollutants:Chemical Oxygen Demand(COD),Total Nitrogen(TN),and Total Phosphorus(TP).Finally,seven model evaluation methods,including uncertainty analysis,were used to evaluate the constructed models and select the optimal models for the three pollutants.The evaluation results indicate that the GPSCNN model performed best in predicting COD and TP concentrations,while the GGACNN model excelled in TN concentration prediction.Compared to existing technologies,the proposed models and evaluation methods provide a more comprehensive and rapid approach to water body prediction and assessment,offering new insights and methods for water pollution prevention and control.
文摘Introduction Types of paper Contributions falling into the following categories will be considered for publication:original articles,review articles,short letters,modelling/theory and methods articles,rapid reports and special thematic issues.Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.
基金supported by Hubei Technology Innovation Center for Smart Hydropower(SDCXZX-JJ-2023-03).
文摘The hot spot temperature of a transformer is one of the critical indicators reflecting its operating status.Accurate and fast calculation of hot spot temperature is significant for the online monitoring of transformers.Considering the low computational efficiency of the transformer’s numerical full model(FM),this paper presents a model simplification method based on the equivalent thermal parameters of windings to expedite hot spot temperature computation.Initially,the representative volume element(RVE)reflecting the periodic structure of windings is selected to formulate a reduced model(RM)for the transformer.Subsequently,to achieve equivalence between the RM and the FM,the equivalent thermal parameters of the RVE are calculated,containing the equivalent thermal conductivity(ETC),the equivalent density(ED),and the equivalent specific heat capacity(ESHC).Finally,the validity of the RM is verified by the temperature rise test.The results show that,compared with the tested data,the maximum error of the hot spot temperature calculated by the RM is 2.56 K,demonstrating the accuracy of the hot spot temperature calculation by the RM.Compared with the FM,the computing time of the proposed RM is reduced to 1/189,which significantly improves the computational efficiency.
基金financially supported by National Natural Science Foundation of China(No.U22B2094)。
文摘An optical emission spectroscopy(OES)method with a non-invasive measurement capability,without inducing disturbance to the discharge,represents an effective method for material monitoring.However,when the OES method is employed to monitor the trace erosion product within the ceramic channel of a Hall thruster,it becomes challenging to distinguish between signal and noise.In this study,we propose a model filtering method based on the signal characteristics of the Hall thruster plume spectrometer.This method integrates the slit imaging and spectral resolution features of the spectrometer.Employing this method,we extract the spectral signals of the erosion product and working gas from the Hall thruster under different operating conditions.The results indicate that our new method performs comparably to the traditional method without model filtering when extracting atom signals from strong xenon working gas.However,for trace amounts of the erosion product,our approach significantly enhances the signal-to-noise ratio(SNR),enabling the identification of extremely weak spectral signals even under low mass flow rate and low-voltage conditions.We obtain boron atom concentration of 3.91×10^(-3) kg/m^(3) at a mass flow rate of 4×10^(-7) kg/s and voltage of 200 V while monitoring a wider range of thruster operating conditions.The new method proposed in this study is suitable for monitoring other low-concentration elements,making it valuable for materials processing,environmental monitoring and space propulsion applications.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.2023YJS053)the National Natural Science Foundation of China(Grant No.52278386).
文摘To fundamentally alleviate the excavation chamber clogging during slurry tunnel boring machine(TBM)advancing in hard rock,large-diameter short screw conveyor was adopted to slurry TBM of Qingdao Jiaozhou Bay Second Undersea Tunnel.To evaluate the discharging performance of short screw conveyor in different cases,the full-scale transient slurry-rock two-phase model for a short screw conveyor actively discharging rocks was established using computational fluid dynamics-discrete element method(CFD-DEM)coupling approach.In the fluid domain of coupling model,the sliding mesh technology was utilized to describe the rotations of the atmospheric composite cutterhead and the short screw conveyor.In the particle domain of coupling model,the dynamic particle factories were established to produce rock particles with the rotation of the cutterhead.And the accuracy and reliability of the CFD-DEM simulation results were validated via the field test and model test.Furthermore,a comprehensive parameter analysis was conducted to examine the effects of TBM operating parameters,the geometric design of screw conveyor and the size of rocks on the discharging performance of short screw conveyor.Accordingly,a reasonable rotational speed of screw conveyor was suggested and applied to Jiaozhou Bay Second Undersea Tunnel project.The findings in this paper could provide valuable references for addressing the excavation chamber clogging during ultra-large-diameter slurry TBM tunneling in hard rock for similar future.
基金Sponsored by National Science and Technology Support Plan of China (2009AA04Z143)Science and Technology Support Plan of Hebei Province of China (10212101D)Important Natural Science Foundation of Hebei Province of China (E2006001038)
文摘The shape of strip is calculated by iterative method which combines strip plastic deformation model with rolls elastic deformation model through their calculation results, which can be called results coupling method. Be- cause the shape and rolling force distribution are very sensitive to strip thickness transverse distribution% variation, the iterative course is rather unstable and sometimes convergence cannot be achieved. In addition, the calculating speed of results coupling method is low, which restricts its usable range. To solve the problem, a new model cou- pling method is developed, which takes the force distribution between rolls, rolling force distribution and strip＇s exit transverse displacement distribution as basic unknowns, and integrates strip plastic deformation model and rolls elas- tic deformation model as a unified linear equations through their internal relation, so the iterative calculation between the strip plastic deformation model and rolls elastic deformation model can be avoided. To prove the effectiveness of the model coupling method, two examples are calculated by results coupling method and model coupling method re- spectively. The results of front tension stress, back tension stress, strip^s exit gauge, the force between rolls and rolling force distribution calculated by model coupling method coincide very well with results coupling method. How- ever the calculation course of model coupling method is more steady than results coupling method, and its calculating speed is about ten times as much as the maximal speed of results coupling method, which validates its practicability and reliability.
文摘Spastic cerebral palsy is generally considered to result from cerebral cortical or pyramidal tract damage. Here, we precisely targeted the left pyramidal tract of 2-month-old Sprague-Dawley rats placed on a stereotaxic instrument under intraperitoneal anesthesia. Based on the rat brain stereotaxic map, a 1-mm hole was made 10 mm posterior to bregma and 0.8 mm left of sagittal suture. A microsyringe was inserted perpendicularly to the surface of the brain to a depth of 9.7 mm, and 15 wL of ethanol was slowly injected to establish a rat model of spastic cerebral palsy. After modeling, the rats appeared to have necrotic voids in the pyramidal tract and exhibited typical signs and symptoms of flexion spasms that lasted for a long period of time. These findings indicate that this is an effective and easy method of establishing a rat model of spastic cerebral palsy with good reproducibility. Ethanol as a chemical ablation agent specifically and thoroughly damages the py- ramidal tract, and therefore, the animals display flexion spasms, which are a typical symptom of the disease.
基金supported by the National Natural Science Foundation of China (11772186 and 11272203)
文摘Dynamic modeling for incompressible hyperelastic materials with large deformation is an important issue in biomimetic applications. The previously proposed lower-order fully parameterized absolute nodal coordinate formulation（ANCF） beam element employs cubic interpolation in the longitudinal direction and linear interpolation in the transverse direction, whereas it cannot accurately describe the large bending deformation. On this account, a novel modeling method for studying the dynamic behavior of nonlinear materials is proposed in this paper. In this formulation, a higher-order beam element characterized by quadratic interpolation in the transverse directions is used in this investigation. Based on the Yeoh model and volumetric energy penalty function, the nonlinear elastic force matrices are derived within the ANCF framework. The feasibility and availability of the Yeoh model are verified through static experiment of nonlinear incompressible materials. Furthermore,dynamic simulation of a silicone cantilever beam under the gravity force is implemented to validate the superiority of the higher-order beam element. The simulation results obtained based on the Yeoh model by employing three different ANCF beam elements are compared with the result achieved from a commercial finite element package as the reference result. It is found that the results acquired utilizing a higher-order beam element are in good agreement with the reference results,while the results obtained using a lower-order beam element are different from the reference results. In addition, the stiffening problem caused by volumetric locking can be resolved effectively by applying a higher-order beam element. It is concluded that the proposed higher-order beam element formulation has satisfying accuracy in simulating dynamic motion process of the silicone beam.
基金co-supported by Aeronautical Science Foundation of China (No. 2010ZB52011)Funding of Jiangsu Innovation Program for Graduate Education (No.CXLX11_0213)
文摘In order to establish an adaptive turbo-shaft engine model with high accuracy, a new modeling method based on parameter selection （PS） algorithm and multi-input multi-output recursive reduced least square support vector regression （MRR-LSSVR） machine is proposed. Firstly, the PS algorithm is designed to choose the most reasonable inputs of the adaptive module. During this process, a wrapper criterion based on least square support vector regression （LSSVR） machine is adopted, which can not only reduce computational complexity but also enhance generalization performance. Secondly, with the input variables determined by the PS algorithm, a mapping model of engine parameter estimation is trained off-line using MRR-LSSVR, which has a satisfying accuracy within 5＆. Finally, based on a numerical simulation platform of an integrated helicopter/ turbo-shaft engine system, an adaptive turbo-shaft engine model is developed and tested in a certain flight envelope. Under the condition of single or multiple engine components being degraded, many simulation experiments are carried out, and the simulation results show the effectiveness and validity of the proposed adaptive modeling method.
