The greatest risks to mammalian pregnancy occur during the peri-implantation period (passage through the uterotubal junction, blastulation, zona shedding, embryonic signaling and recognition, blastocyst attachment, po...The greatest risks to mammalian pregnancy occur during the peri-implantation period (passage through the uterotubal junction, blastulation, zona shedding, embryonic signaling and recognition, blastocyst attachment, postattachment events initiating placentation). Conventional markers and screening methods do not provide the means to clarify the relationship between exposure of a reproductively competent woman to a xenobiotic compound and the specific error in the functional expression of an embryogenetic process identified by impairment or deletion of that process. Laboratory models which provide the flexibility of in vitro culture methods and allow integration of cellular and molecular techniques have identified cell-specific, stage-specific markers that could focus on the mechanism of xenobiotic action. In vitro models have been used to define postattachment trophoblast cell differentiation. Trophoblast specific peptide hormones prove to be valid markers of established pregnancy. They provide no assessment of the risk to the embryo during the peri-implantation period. The relationship between developmental time of exposure and risk is discussed in terms of trophoblast differentiation.展开更多
The State Key Laboratory of Numerical Modelling for Atmospheric Science and Geophysical Fluid Dynamics (LASG) was established in 1985. It was considered an Excellent Opening Laboratory in the national assessment organ...The State Key Laboratory of Numerical Modelling for Atmospheric Science and Geophysical Fluid Dynamics (LASG) was established in 1985. It was considered an Excellent Opening Laboratory in the national assessment organized by the former State Science and Technology Committee (now the Ministry of Science and Technology) in 1988. Because of this, LASG was upgraded to a State Key Laboratory in 1989. It won the honor of "Excellent展开更多
The growing demands on global infrastructure highlight the critical need for durable and efficient pavement systems,particularly under the stress of repetitive heavy traffic loads.The use of geosynthetics within the p...The growing demands on global infrastructure highlight the critical need for durable and efficient pavement systems,particularly under the stress of repetitive heavy traffic loads.The use of geosynthetics within the pavement structure increases the load-carrying capacity of unbound pavement layers by providing lateral restraint,improving vertical stress distribution,and enhancing bearing capacity.Such reinforcement typically aims to either improve the service life of pavements or achieve equivalent performance with a reduced granular cover.Previous and ongoing research quantifies geosynthetic performance in pavement reinforcement using various testing methods.Among these,laboratory model box tests subjected to cyclic loading are pivotal,as they closely replicate real-world traffic conditions.Hence,these studies are essential for understanding how geosynthetics distribute loads and enhance pavement durability.This facilitates the development of optimized geosynthetic design and installation practices,accelerating the loading process to simulate years of traffic wear in a shorter period.This review discusses the improved rutting resistance of unbound pavements reinforced with geosynthetic materials,specifically drawing on data from cyclic plate load tests conducted on laboratory model boxes,as highlighted in the literature.Key variables such as optimum geosynthetic placement,geosynthetic material properties,performance of different geosynthetic materials and the effects of aperture shape and size on rutting resistance are discussed.Furthermore,the review assesses various predictive rutting models,analysing their applicability and accuracy in forecasting the rutting performance of geosynthetic-reinforced unbound pavements.This comprehensive literature review aids pavement engineers and researchers,in guiding the selection and design of geosynthetics to optimize pavement durability and functionality under repetitive traffic loads.展开更多
An inverse analysis procedure has been developed to interpret collected pore pressure data and observations during backward erosion piping(BEP)initiation and progression in sandy soils.The procedure has been applied t...An inverse analysis procedure has been developed to interpret collected pore pressure data and observations during backward erosion piping(BEP)initiation and progression in sandy soils.The procedure has been applied to laboratory models designed to mimic the initiation and progression of BEP through a constricted vertical outlet.The inverse analysis uses three-dimensional(3D)finite element method(FEM)to successively produce models of the hydraulic head regime surrounding progressive stages of BEP based on observations at the sample surface and pore pressure measurements obtained from the laboratory models.The inverse analysis results in a series of 3D contour plots that represent the hydraulic-head regime at each stage of the BEP development,allowing for assessing the development of BEP mechanism as well as calculating the critical hydraulic conditions required for various BEP stages to initiate and progress.Interpretation of the results identified four significant stages of the piping process:(1)loosened zone initiation,(2)channel initiation and progression,(3)riser sand fluidization,and(4)loosened zone progression.Interpretation of the hydraulic head contour plots allows assessment of the critical hydraulic gradients needed to initiate and progress various components of the BEP development.展开更多
Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they cause.However,barrier structures constructed along the path of a rock avalanche can partia...Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they cause.However,barrier structures constructed along the path of a rock avalanche can partially mitigate the magnitudes and consequences of such catastrophic events.We selected a rock avalanche in Nayong County,Guizhou Province,China as a case to study the effect of the location and height of a retaining wall on the dynamic characteristics of rock avalanche by using both actual terrain-based laboratory-model tests and coupled PFC3D-FLAC3D numerical simulations.Our findings demonstrate that a retaining wall can largely block a rock avalanche and its protective efficacy is significantly influenced by the integrity of the retaining wall.Coupled numerical simulation can serve as a powerful tool for analyzing the interaction between a rock avalanche and a retaining wall,facilitating precise observations of its deformation and destruction.The impact-curve characteristics of the retaining wall depend upon whether or not the rock avalanche-induced destruction is taken into account.The location of the retaining wall exerts a greater influence on the outcome compared to the height and materials of the retaining wall,while implementing a stepped retaining-wall pattern in accordance with the terrain demonstrates optimal efficacy in controlling rock avalanche.展开更多
The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is studied.Convection is driven by localized cooling at the center of the upper free surface and by rim heatin...The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is studied.Convection is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the sidewall.The horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex structure.The mean meridional circulation,consisting of three cells,provides a strongly non-uniform differential rotation.As a result of the instability of the main cyclonic zonal flow,the train of baroclinic waves appears in the upper layer.The baroclinic waves provide most of the heat transfer in the middle radii and are responsible for strong temperature and velocity fluctuations.It is shown that the inclination of the bottom is a crucial factor for the structure of the convective cells and the dynamics of the baroclinic waves.The increase in the inclination angle leads to a significant increase in the energy of the waves.The obtained results may be important for heat and mass transfer in various geophysical and industrial systems,including transport of various additives and impurities in rotating crucibles,and crystallization processes.展开更多
基金Support for these studies was provided by grants from the National Institutes of Health (HD-22785,HD-25189, HD-07495).
文摘The greatest risks to mammalian pregnancy occur during the peri-implantation period (passage through the uterotubal junction, blastulation, zona shedding, embryonic signaling and recognition, blastocyst attachment, postattachment events initiating placentation). Conventional markers and screening methods do not provide the means to clarify the relationship between exposure of a reproductively competent woman to a xenobiotic compound and the specific error in the functional expression of an embryogenetic process identified by impairment or deletion of that process. Laboratory models which provide the flexibility of in vitro culture methods and allow integration of cellular and molecular techniques have identified cell-specific, stage-specific markers that could focus on the mechanism of xenobiotic action. In vitro models have been used to define postattachment trophoblast cell differentiation. Trophoblast specific peptide hormones prove to be valid markers of established pregnancy. They provide no assessment of the risk to the embryo during the peri-implantation period. The relationship between developmental time of exposure and risk is discussed in terms of trophoblast differentiation.
文摘The State Key Laboratory of Numerical Modelling for Atmospheric Science and Geophysical Fluid Dynamics (LASG) was established in 1985. It was considered an Excellent Opening Laboratory in the national assessment organized by the former State Science and Technology Committee (now the Ministry of Science and Technology) in 1988. Because of this, LASG was upgraded to a State Key Laboratory in 1989. It won the honor of "Excellent
基金financial and intellectual support provided by Queensland University of Technology(QUT)through its Higher Degree Research Program.
文摘The growing demands on global infrastructure highlight the critical need for durable and efficient pavement systems,particularly under the stress of repetitive heavy traffic loads.The use of geosynthetics within the pavement structure increases the load-carrying capacity of unbound pavement layers by providing lateral restraint,improving vertical stress distribution,and enhancing bearing capacity.Such reinforcement typically aims to either improve the service life of pavements or achieve equivalent performance with a reduced granular cover.Previous and ongoing research quantifies geosynthetic performance in pavement reinforcement using various testing methods.Among these,laboratory model box tests subjected to cyclic loading are pivotal,as they closely replicate real-world traffic conditions.Hence,these studies are essential for understanding how geosynthetics distribute loads and enhance pavement durability.This facilitates the development of optimized geosynthetic design and installation practices,accelerating the loading process to simulate years of traffic wear in a shorter period.This review discusses the improved rutting resistance of unbound pavements reinforced with geosynthetic materials,specifically drawing on data from cyclic plate load tests conducted on laboratory model boxes,as highlighted in the literature.Key variables such as optimum geosynthetic placement,geosynthetic material properties,performance of different geosynthetic materials and the effects of aperture shape and size on rutting resistance are discussed.Furthermore,the review assesses various predictive rutting models,analysing their applicability and accuracy in forecasting the rutting performance of geosynthetic-reinforced unbound pavements.This comprehensive literature review aids pavement engineers and researchers,in guiding the selection and design of geosynthetics to optimize pavement durability and functionality under repetitive traffic loads.
基金support from the South China University of Technology for the PhD short-term visiting project。
文摘An inverse analysis procedure has been developed to interpret collected pore pressure data and observations during backward erosion piping(BEP)initiation and progression in sandy soils.The procedure has been applied to laboratory models designed to mimic the initiation and progression of BEP through a constricted vertical outlet.The inverse analysis uses three-dimensional(3D)finite element method(FEM)to successively produce models of the hydraulic head regime surrounding progressive stages of BEP based on observations at the sample surface and pore pressure measurements obtained from the laboratory models.The inverse analysis results in a series of 3D contour plots that represent the hydraulic-head regime at each stage of the BEP development,allowing for assessing the development of BEP mechanism as well as calculating the critical hydraulic conditions required for various BEP stages to initiate and progress.Interpretation of the results identified four significant stages of the piping process:(1)loosened zone initiation,(2)channel initiation and progression,(3)riser sand fluidization,and(4)loosened zone progression.Interpretation of the hydraulic head contour plots allows assessment of the critical hydraulic gradients needed to initiate and progress various components of the BEP development.
基金Hunan Provincial key Laboratory of key Technology on Hydropower Development Open Research Fund (PKLHD202203)
文摘Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they cause.However,barrier structures constructed along the path of a rock avalanche can partially mitigate the magnitudes and consequences of such catastrophic events.We selected a rock avalanche in Nayong County,Guizhou Province,China as a case to study the effect of the location and height of a retaining wall on the dynamic characteristics of rock avalanche by using both actual terrain-based laboratory-model tests and coupled PFC3D-FLAC3D numerical simulations.Our findings demonstrate that a retaining wall can largely block a rock avalanche and its protective efficacy is significantly influenced by the integrity of the retaining wall.Coupled numerical simulation can serve as a powerful tool for analyzing the interaction between a rock avalanche and a retaining wall,facilitating precise observations of its deformation and destruction.The impact-curve characteristics of the retaining wall depend upon whether or not the rock avalanche-induced destruction is taken into account.The location of the retaining wall exerts a greater influence on the outcome compared to the height and materials of the retaining wall,while implementing a stepped retaining-wall pattern in accordance with the terrain demonstrates optimal efficacy in controlling rock avalanche.
基金supported by Russian Science Foundation Grant RSF-22-21-00572(https://rscf.ru/project/22-21-00572/).
文摘The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is studied.Convection is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the sidewall.The horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex structure.The mean meridional circulation,consisting of three cells,provides a strongly non-uniform differential rotation.As a result of the instability of the main cyclonic zonal flow,the train of baroclinic waves appears in the upper layer.The baroclinic waves provide most of the heat transfer in the middle radii and are responsible for strong temperature and velocity fluctuations.It is shown that the inclination of the bottom is a crucial factor for the structure of the convective cells and the dynamics of the baroclinic waves.The increase in the inclination angle leads to a significant increase in the energy of the waves.The obtained results may be important for heat and mass transfer in various geophysical and industrial systems,including transport of various additives and impurities in rotating crucibles,and crystallization processes.
